LOCUS       c00063_gnlPro..        13699 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IHDPDMPB_63.
ACCESSION   c00063_gnlPro..
VERSION     c00063_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 12:51:35
            Original ID  :: gnl|Prokka|IHDPDMPB_63
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13699
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13699
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1131:11138]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1132..11138
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..13699
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13699
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(3..62)
                     /locus_tag="ctg63_1"
                     /transl_table=11
                     /translation="MNIKNKTQNRFFVEVLKLLY"
     CDS             239..967
                     /locus_tag="ctg63_2"
                     /transl_table=11
                     /translation="MAIAACCSVPALASPGSLEPSAGTSYVAGTATTTEGIALGKDMTF
                     GSLSQSALPGSSIPYGGNFYASNYTISLWLDTSSLTEGTQTTLFGYYGTNVGQSYGTNA
                     LYLTSDAKLGMGDGNLNTSTGSFSQNRGDVSEASVVLGGGLLNVTLAVTGADQSQSVDV
                     YVNGSLLDTLSYNGNMNGNRSDIQSWINPNLTWGEIQWTDTKLSAEQIAGFAGLQVPEP
                     ASASLGILGLAVLMMRRRRS"
     CDS             1132..2862
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.1e-34, bitscore:
                     108.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYRVADQIVEILEKAGVKRIYGIVGDSLNPVTDALRRRKTIEWIH
                     VRHEEVAAFAASAEAQLSGNLAVCCGSSGPGNLHLINGLFDAHRNHAPVLAIAFHIPQS
                     QVGMEYFQATHPEQLFKECSAYAELVSEASQAPSILMSAIQHAWARRDVGVVVLPGDIA
                     DAPAEMKNLVHPPSYTRENVVPEHESVSLLARMLDDHRRITFFCGAGCAGAEDKVVRLA
                     HRLKAPIAYTWRGKDHFEHDNPLGIGMTGLLGWGDAYKAMHESDMLVLWGTDFPYFNFI
                     PTKPEIVQIDRRGEVLGRRCRLDLGICGDVSVTAEALLNMVQEKTDSGHLDAALKRHAR
                     DVKEMNAYMEGNDKESPIRPEQLTTALNRHAASDAVFTVDTGTPCIWSARFLCATPGRR
                     TLASFNHGSMANAMPMAIGAQMEYPERQVIALCGDGGLSMLLGDLITIVQYRLPVKIVV
                     YNNDCLDFIQLEMQAAGLIPWQINLNNPSFAAVADAVGIKGFLLDKSSQVDQMVDMFLN
                     YPGAALLDAHVDRDALALPPYISMGQAADFSLAMMKQTLAGEVKQVWNTLAGNRKLFKP
                     "
     CDS             complement(2917..4386)
                     /locus_tag="ctg63_4"
                     /transl_table=11
                     /translation="MAISDYIVTIGLEVHCQIKTKSKMFCSCETGFGFEPNTRVCPTCL
                     GLPGALPVLNEFAIERTLLTGLMLGCSSPEISQWDRKNYFYPDMAKNYQTSQLDLPLCL
                     GGEVPLYPWSYPNDVIKAGIPPFRTVKLTRIHLEEDAAKITHHANYSLIDYNRAGSALM
                     EIVSEPDIDTPEEAYAYLKSLQQILNYGDISDADMEKGQMRCDVNISLRPHGQKELGAK
                     VEMKNINSMSAVRRALHYEIQRQAEELDMGIPQXXXXPRRWDDERGESVVMRTKEDAHD
                     YRYFPCPDLVPVRTAPLVEKVRGQIPELPQERQKRFMEEYGLSEYDANVLVGDLELARF
                     FEEAARGTASGKKIANWVINNISAVLNEKGMRPSECPVKPGAIRELIAIIDDGTVSNNQ
                     AKDVFAKMWDEPALAAAQAAKLLGFEKADSSFLDGIVREVISANPDKVAEIQGGNEKLL
                     NWLTGQVMKAAKGKANPKIVTEALKKALSME"
     CDS             complement(4755..5486)
                     /locus_tag="ctg63_5"
                     /transl_table=11
                     /translation="MNDTAAAILKATAALRDGTEKLRFESPVHVTYNPLTYAWGPHEQY
                     VRTYGNGEKSHLFLGMNPGPFGMAQTGVPFGEVDAVVNWLHIRGEVGRPEHTHPKRPVE
                     GFGWPRSEVSGRRLWGLFAEAFGTAENFFRHNYVANYCPLIWMGATGANITPDKLPAEQ
                     RAAVDAVCMEHLLSLITILNPHTLVGVGAYATQKLRDAASRLPGKSFTIGTLLHPSPAS
                     PIANKLWPEHPIQQLKELGIL"
     CDS             5615..6559
                     /locus_tag="ctg63_6"
                     /transl_table=11
                     /translation="MTSGGDAAGMNPAIKAAVDHARQLGMNPYVVYDGLEGLIDGKIKE
                     ATRELTNDMIYRGGTLLRSSRSKRFFDYEFRKQAYEHLKERNIDKLIIMGGDGSFRALN
                     DFFNDFEVPFAGIPATIDNDIAGTDYCLGVDTAQNVILDCIDSVRDTARSHHRAFVIET
                     MGRDCGYLAMTTALCSAADICIVPEIPYDLESIYKRLQPVINEEGSCIIAVVAEGTRVA
                     QYLTRWLTERAGMDTRLTVLGHVQRGGSPTARDRLMGTRFATRAVEALNNGDINQIMVY
                     HDGQYGYASLDSVAGQQYSVNQDIINLCRELSC"
     CDS             6691..7743
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GDP_Man_Dehyd"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg63_7"
                     /sec_met_domain="GDP_Man_Dehyd (E-value: 2.2e-99, bitscore:
                     322.6, seeds: 258, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVIVTGGAGFIGSNLVRLLLERGHEVLNIDALTYAGNIHSLDGS
                     ADSPAYRFLHADVRDASLMRRTLREYAPDWVMHLAAESHVDRSIDDPGNFMTTNVMGTF
                     SMLQAALEYYRSLEGEKKERFRFHHISTDEVYGSLGKEGLFTESTPYRPHSPYSASKAS
                     SDHLVRAWHDTYGLPVLITNCSNNYGPYQFPEKLIPVVILKALGGEPIPVYGKGENVRD
                     WLYVGDHCEALLTVVSCGKPGETYNIGGNNEKTNLELVELLCSHLDELRPRPDGRSYRE
                     QISFVQDRPGHDLRYAIDASKIRRELGWTPRQDHSSGFRKTIQWYLDHEEWWRGILSGE
                     YRLERLGTNG"
     CDS             7753..8616
                     /locus_tag="ctg63_8"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLHPVTLSVSKQLLPVYDKPMVYYPISVLMLAG
                     IREILVISTPRDLPLYRDLLGDGSRFGVSFKYREQPRPEGLAQAFIIGEEFIGKDSVAL
                     VLGDNIFYGRGLTEKLRRAAELTSGATIFGYQVHDPQRFGVVEFNEEGKAVSIEEKPPR
                     PKSDIAVTGLYFYDNRVVEIAKRIPKSSRGELEITSVNQEYLKQGLLRVEKLARGYTWL
                     DTGTHDTLLEASMFVRTLEHHQGFKVACLEEIAFNNGWISQETLRSQAGAMNNNGYGRY
                     LDELVK"
     CDS             complement(8761..9522)
                     /locus_tag="ctg63_9"
                     /transl_table=11
                     /translation="MNWMIYPAARAFIKVCSVLFGTGAAAAVLIHLFMPFFLRSPRTAA
                     PFLLLGTGAELLSILSLSFLMFWGVRVLLASRGSRITRNLSMLAFLPALYALLIPFAGM
                     PVPSQYTEMDRVWEAVLLLSAVTSFFSFPYTAGYGAAGRRLFLAWGIAAAGCGLQSALF
                     FLAVLLRQFLSTAVPSLAAPVAWLAVLLSCGLEIMLAALSAILAQRLFKEVMSIASMPX
                     XXXXXXXXXPSLTFLPSVFTGLPEEHPHSPA"
     CDS             complement(9642..11138)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: AcetylCoA_hydro"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: AcetylCoA_hyd_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_10"
                     /sec_met_domain="AcetylCoA_hyd_C (E-value: 6.8e-47,
                     bitscore: 148.9, seeds: 181, tool: rule-based-clusters)"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 4.8e-44,
                     bitscore: 140.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYKVLTPEEAASLIKHGHHIGLSGFTPAGTAKAVTAALAKIAEA
                     EHEKGNPFQVSVFTGASTGDSCDGILSRAKAIRYRAPYTTNVDFRKAVNNGEIAYNDIH
                     LSQMAQEVRYGFMGNVDIAIIEACEVTADGKIYLTAAGGIAPTICRLADKIIVELNAAH
                     SKSAMGLHDVYEPLDPPYRREISIFKPSDRIGKPYIQVDPKKIVGVVETNWPDEARSFA
                     AADPLTDKIGQNVADFLAADMKRGIIPSTFLPLQSGVGNIANAVLGALGRDKTIPAFEM
                     YTEVIQNSVIGLIREGRVKFGSACSLTVTNDCLEGIYRDMDFFRDKLVLRPSEISNSPE
                     VIRRLGVISINTAIEADIYGNVNSTHIGGTKMMNGIGGSGDFTRNAYISIFTCPSVAKD
                     GKISAIVPMVSHHDHTEHDVNIIITEQGVADLRGKSPKERAQTIIENCVHPDYKNILWD
                     YLKLSDGKAQTPQSIRAALGMHAELARSGDMKNVDWAQYK"
     CDS             complement(11200..11979)
                     /locus_tag="ctg63_11"
                     /transl_table=11
                     /translation="MNSAASFSTPPEEEGPCGDWTYHEWAEAFSTNDLARALPPGHIAV
                     CRVQTGGRGRFNRKWIGEEGGLWASFTVPLSAPEDTAAGVHWGHLPLVAGLALFNMLRG
                     MGLDSVRLRWPNDLLAGKSKLAGILVERPAENMAVIGIGINVFNDVSSIAGEIKDPPAR
                     LADLVRDCPSLHAVMASLGSHLNQVLSVFSHGGVPALQEGLSRAWAGERPVSILTDDET
                     VRGIFTGIDDQGNPVLSLPAGTVRTIPAHLINRLLEE"
     CDS             complement(12017..13642)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OAD_beta"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg63_12"
                     /sec_met_domain="OAD_beta (E-value: 1.3e-159, bitscore:
                     520.4, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVFSLSWQMVGMWGIAILLLYLGVAKQYEPLLMVPIAFGALIAN
                     IPDNGMLITQLNQQVISSNEQGEVTATSLNNVGYLRVHVAPLQQAPSKVPANLTTPESR
                     SQYQEIMQQPMQVYPGSQLTVSKIKSVRESQEKAKADAARLGDDSLTVDPNLKDFQNVT
                     EDNGNEPVFLLTNGEGTTVVRQQGVNYFDTSGNRIPVDLKTQKLEPLVVSAAGKYVAVG
                     QHTQELLVTSIHGGLYDWIGLGIKAEIFPPIIFLGVGALTDFGPLLAAPRTLLLGAAAQ
                     VGVAATFFMALFMGFTPNESASIGIIGGADGPTSIFLTMKLAPHLLGAVAVAAYTYMSL
                     VPLIQPPIMALLTTKKERLIRMKSLRTVSKSEKLFFAVLVTIVTILLIPDASPLIGMLM
                     LGNFLRECKVTERLVQASQNEIINIVTIFLGTSVGLTMQGDRFLQSETLLIILLGIVAF
                     GVATAGGVIAAKIMNLIWRKNPVNPLIGSAGVSAVPMAARVSHNVGQKYDPSNYLLMHA
                     MGPNVAGVIGTAVIAGYYIATLAK"
ORIGIN
        1 ctatacagca acttcagaac ctccacaaaa aatctattct gcgttttatt ttttatattc
       61 ataagtgata gaaggtaatt atattatatt ttttagcgga ttgaaaaagc ttgttctcat
      121 ctttcctgtg ggggagaaaa agagcggatt gggaatccga tatacagagg gcggggaata
      181 tctctctgat tgctactcag tccatcattc acagaaaatg aaaaaaacat tagcattaat
      241 ggccattgcg gcgtgttgtt ccgttccggc gttggcgtct cccggctctt tagaaccatc
      301 ggccggaacg tcttacgttg ccggtacggc gacgacaacc gaaggtattg cattgggaaa
      361 agacatgacg tttggaagtc tctcacaaag tgcccttcct ggcagttcca ttccttacgg
      421 cggtaatttt tatgcttcca attacacgat ctccctctgg ctggatactt cttccttaac
      481 ggaaggaacc cagaccacgc tgtttgggta ttatggcacc aatgtgggcc aaagttacgg
      541 gacaaatgcc ttgtatctga cgtcagatgc caagctgggc atgggagatg ggaacttgaa
      601 tacttctacc ggctcttttt cccaaaaccg tggagacgtt tctgaagctt ccgttgtttt
      661 ggggggaggt cttcttaacg tgactttggc cgttaccggc gcagaccaaa gccagtctgt
      721 ggatgtctat gtgaatggtt ccttgcttga cacgttgtcc tacaacggca acatgaacgg
      781 aaatcgctct gatatccaaa gctggattaa tcccaatctt acatggggtg aaattcagtg
      841 gacggataca aaactttccg cggaacagat tgccggtttt gccggccttc aggttccgga
      901 accggcctcg gcttctctgg gaatcctggg cctggccgtt ctgatgatgc gccgccgccg
      961 ttcctgacgg ttttccacca gagaactggt aaattcatag gccgctgcct gaaaaggcgg
     1021 cggctttatg atatcagggg aaatcctcag gcattttttc cggtgcggaa aagatggagg
     1081 ggatgacaca taagaatgaa tccgttggag gttggctggt gtctaatctg catgtacagg
     1141 gtagccgatc agattgttga aattttggag aaggcgggag ttaagcggat ttacggcatt
     1201 gtgggggata gcctgaaccc cgttacggac gctttgagga ggaggaagac cattgaatgg
     1261 attcatgtgc ggcatgagga agtggcggct tttgccgcga gcgcggaagc ccagctgagc
     1321 gggaatctgg ctgtatgctg cggcagcagc ggccccggga acctccattt gatcaacggc
     1381 ctgtttgacg cccaccggaa ccatgccccg gtgctggcca ttgctttcca catcccgcag
     1441 agccaggtag gcatggaata tttccaggcc acgcatccgg aacagctttt caaggaatgc
     1501 agtgcatatg cggaactggt ttcggaagct tcccaggccc cgtccatttt gatgtccgcc
     1561 attcagcacg cgtgggccag gcgcgacgta ggcgtcgtcg tcttgcccgg agacattgcg
     1621 gacgcccctg cggagatgaa gaatctggtg catcctcctt cctacacgcg ggagaatgtt
     1681 gttcctgagc atgaatccgt atcccttctg gcacggatgc ttgacgacca ccgccgcatt
     1741 actttcttct gcggcgccgg ctgcgcggga gcggaagaca aggtcgtccg gctcgcgcac
     1801 cgcctgaaag ctccgattgc ctacacatgg aggggaaagg atcattttga acatgacaat
     1861 cccctgggca tcggcatgac ggggctgctg ggatggggag atgcctacaa ggccatgcat
     1921 gaaagcgaca tgctcgtgtt gtgggggacg gatttcccct atttcaattt cattcccacc
     1981 aaacctgaaa tcgtgcagat tgacaggcgc ggtgaagtgc tgggccgccg ctgccgcctg
     2041 gacctgggta tttgcgggga tgtttccgtc acggcggaag ctctgctgaa catggtgcag
     2101 gaaaagacgg attccgggca tttggatgcc gccctgaaac gccacgccag ggacgtgaag
     2161 gagatgaacg cctatatgga aggaaatgac aaggagtctc ccatccggcc ggaacagctc
     2221 acgaccgccc tgaacaggca tgcggcatcc gacgccgtat ttacggtaga taccggcacc
     2281 ccctgtatct ggagcgccag gttcctgtgc gccacgccgg gaaggaggac gctggcttcc
     2341 ttcaatcatg gctccatggc caatgccatg ccgatggcta ttggggcgca gatggaatac
     2401 cccgaacggc aggtaattgc cctgtgcgga gatggcggcc tgtccatgct gctgggggat
     2461 ctcatcacga ttgtccagta caggctgccg gtgaaaatcg tggtgtataa caatgactgt
     2521 ctggatttca tccaattgga aatgcaggcg gccgggctga ttccgtggca gatcaacctg
     2581 aacaacccct cttttgccgc cgtggcggat gccgtcggca tcaaggggtt tttattggac
     2641 aaatccagcc aggtggacca gatggtggac atgttcctga attatccggg cgccgctctg
     2701 ctggacgcgc atgtggacag ggacgccctt gccctgcctc cctacatcag tatgggccag
     2761 gcggcggact tttcccttgc catgatgaag cagacgctgg ccggggaagt gaagcaggta
     2821 tggaacaccc tggccggaaa caggaagctg ttcaaaccgt gatgccctgc gggcaaggag
     2881 ccggcatcgg caagggaagc ggctctttgt ttatggtcac tccatggaaa gggctttttt
     2941 cagcgcttcc gtcacgattt tcgggttggc tttgcctttg gcggccttca tgacctggcc
     3001 ggtaagccag ttcaggagct tttcattgcc cccctgtatt tccgccacct tgtccggatt
     3061 ggcggaaatg acttcccgca cgatgccgtc cagaaaagag gaatccgcct tttcaaagcc
     3121 cagcagcttg gcggcctgcg ctgcggcgag ggccggctca tcccacattt tggcgaatac
     3181 gtccttggcc tggttgttgg aaacggtgcc gtcgtcaata atggcgatca gctcccggat
     3241 ggcgccgggt ttcaccgggc attcagacgg gcgcatgcct ttttcattca gcacggcgga
     3301 aatgttgtta atcacccagt tggcgatttt tttgccgctg gcggttcccc gcgccgcctc
     3361 ttcaaaaaag cgtgccagtt ccaggtctcc caccagcacg ttggcgtcgt actcgctcag
     3421 gccgtattct tccatgaagc gtttctgccg ttcctgaggc agttcgggaa tctgcccgcg
     3481 cactttctcc accagcgggg ccgtgcgtac gggaaccaga tccggacagg ggaaataacg
     3541 gtaatcgtgc gcgtcttcct tggttcgcat gacgacgctt tctccgcgtt cgtcgtccca
     3601 gcggcggggg gnnnnnnnnn nttgaggaat gcccatgtcc agttcttccg cctggcgctg
     3661 gatttcataa tgaagggctc tgcggacggc ggacatggag ttgatgttct tcatttccac
     3721 cttggcgccc aattccttct gcccgtgggg acgcagggaa atattcacat cgcaccgcat
     3781 ctggcccttt tccatgtccg cgtcggagat atccccgtaa ttcaaaatct gctggaggga
     3841 cttgaggtag gcgtaggctt cttccggggt gtcgatgtcc ggctcggaaa cgatttccat
     3901 cagggcggac cccgcgcggt tgtagtcgat cagggaataa ttggcatgat gggtaatctt
     3961 cgccgcgtct tcttccagat ggatgcgggt cagcttcacg gtgcggaaag gggggatgcc
     4021 ggctttgatc acgtcattcg gataggacca ggggtacagg ggcacttccc ctcccaggca
     4081 cagcggaaga tccagctggg aggtctggta atttttagcc atgtccggat agaaataatt
     4141 tttgcggtcc cattgggaaa tctccgggct ggagcatccc agcatcaggc cggtcagcag
     4201 cgtgcgttca atggcgaact cattcaggac gggcagggcg cccggcagcc ccaggcaggt
     4261 ggggcacacg cgcgtattgg gttcaaagcc aaagccggtc tcgcaggagc agaacatttt
     4321 gctctttgtc ttgatctggc agtggacttc caggccaatg gtcacgatgt aatctgaaat
     4381 tgccataaat tcggaacgct tgaagatcgc ggaaactgta cggaaccctt ttccccctgt
     4441 ccagtaaaaa ggcctgcggg ggagagcgga gggttttcag tctaagaatg atgattgatt
     4501 tggagggagg ctgatttttg tggtggaagt ggggaggcgt ttaagttctt ctctgtcccg
     4561 gtagatgccg gcgtgctttt cttccgtcag gaaggctgtg tccctgggca aatcaagcca
     4621 gtaaaggggg ccggatattc cttcaaaacg atgtagattt ggaggagaac aagatgaact
     4681 gccgatttcc ggcctgtcgc tctggtgatt ccttccatgt cacggagctt tccactctac
     4741 ctcctccgct ctttttataa aatgcccagt tccttaagct gctggatggg gtgttccggc
     4801 cagagcttgt tggcgatggg gctggcgggg cttgggtgga gcaacgtgcc gatggtgaag
     4861 cttttgccgg ggagccggga ggcggcgtcc cgcagcttct gcgtggcgta ggcacccaca
     4921 cccaccagcg tgtggggatt caggatggtg atgagggaaa gcaggtgttc catgcatact
     4981 gcgtccacgg cggcgcgctg ttccgccggc agtttgtccg gcgtaatgtt ggctccggtg
     5041 gctcccatcc agatcagcgg acagtaattg gccacgtaat tgtgacggaa gaagttttcc
     5101 gcagttccga aagcttccgc gaaaagtccc cagaggcggc ggccgctgac ttccgacctg
     5161 ggccagccga aaccctccac gggacgtttg gggtgggtat gttccggccg cccgacttct
     5221 ccgcgaatgt gcagccagtt gacgacggcg tccacttccc cgaaggggac gcctgtctgg
     5281 gccatgccga aggggccggg attcatgccc aggaacagat ggctcttttc cccgtttccg
     5341 taggtgcgca catactgttc atgcggcccc catgcatagg tgagagggtt gtaggtaaca
     5401 tggaccgggg attcgaaccg gagcttctcc gtgccgtccc ggagggcggc cgtggctttc
     5461 agaatggctg ctgcagtgtc gttcatgcct ccgcatcatg aagtgttgcc gtttattgcg
     5521 ccagtaaaaa ctccgcgctt gcattatttg ttccgcccgg taacatttcc ccccggacaa
     5581 gttaacctta ttacttatga gtggaatagc cattatgaca tctggcggtg atgccgccgg
     5641 aatgaacccg gcgatcaagg cggcagtgga tcatgcccgc cagcttggga tgaacccgta
     5701 cgttgtttat gacggcttgg aagggctgat cgatggaaaa atcaaggaag ccacccggga
     5761 actgaccaac gatatgatct acaggggcgg aactctcctc cgttcctcac gatccaagcg
     5821 ctttttcgac tacgaattcc gcaagcaggc ctacgaacat ctgaaggaac gcaacatcga
     5881 caagctcatc atcatgggcg gggacggttc cttccgcgcc ctgaacgact ttttcaatga
     5941 ttttgaagtg ccttttgccg gtattccggc tacgattgac aacgacattg ccggaacgga
     6001 ctactgcctg ggcgtggata cggcccagaa cgtgattctg gattgcattg attccgttcg
     6061 tgatacggcc cgttcccatc accgcgcttt cgtgattgaa acgatgggcc gggactgcgg
     6121 ctatctggcg atgaccaccg ctctttgcag cgcggcggat atctgcattg tccctgaaat
     6181 tccgtatgat ctggaatcca tttacaagcg cctccagcct gtcatcaatg aggaaggaag
     6241 ctgcatcatt gccgtggtgg cggaaggcac ccgcgtggcg cagtacctga cccgctggct
     6301 gacggaacgc gccggcatgg atacccgcct gaccgtgctg ggccatgtgc agcgcggcgg
     6361 ttcccccacc gcccgtgacc gcctgatggg cacccgtttt gccacccgcg ccgtggaagc
     6421 tctgaacaac ggggacatca accagatcat ggtgtatcat gacggccagt acggctatgc
     6481 ctccctggat tccgtagccg ggcagcagta ctccgtgaac caggatatca tcaacctttg
     6541 ccgggagctg agctgctagc cgtctcagcg gttacggaac ccgctttttc ccgcctatgc
     6601 cgccacgttc ccgcggcatg ggcggatttg ttttgaaaaa aaacgccgct gctgtatgat
     6661 ggcgccgcat ctttccctga aaacagtgct atgaaagtta tcgttacggg cggcgccgga
     6721 ttcatcggct ccaatctggt caggctgctg ctggagcgcg gccatgaagt cctgaatatt
     6781 gacgctctga cctatgccgg caacatccat tcactggacg gctcggcgga ttctccggca
     6841 taccgctttc tgcacgccga cgtccgggac gcttccctga tgcggcgcac tttgcgggag
     6901 tacgctccgg actgggtgat gcacctggcg gcggaatccc atgtggaccg ttccattgac
     6961 gatccgggaa attttatgac caccaacgtc atgggcactt tttccatgct tcaggccgcc
     7021 ctggaatatt accgttccct ggagggagag aaaaaggagc gtttccgctt ccaccacatt
     7081 tccacggatg aagtgtacgg ctccctggga aaggaaggcc tgttcacgga gtccacgccg
     7141 tatcgccccc attccccgta ttccgccagc aaggcctcca gcgaccacct ggtgcgcgcc
     7201 tggcacgata cgtacgggct gcccgtgctg atcaccaact gttccaacaa ttacggccct
     7261 taccagttcc cggaaaagct gatacccgtc gttatcctga aagcgctggg cggggaaccc
     7321 attcctgtat acggcaaggg ggaaaacgtg cgggactggc tgtatgtggg ggatcactgc
     7381 gaggcgctgt tgacggtcgt ttcctgcgga aaaccggggg aaacgtacaa catcggcggc
     7441 aataacgaga aaaccaatct ggagctggtg gaactgctgt gttcccatct ggatgaactg
     7501 cggccccgtc cggacggccg gagctaccgg gagcaaatct cctttgtgca ggacaggccg
     7561 ggccatgacc tgcgctatgc gattgacgct tccaaaatac ggagggaatt ggggtggact
     7621 ccgcgccagg accattcttc cggattcaga aagaccattc agtggtatct ggaccatgag
     7681 gaatggtggc ggggcatcct gtccggggaa taccgcctgg aacgtcttgg aaccaatggc
     7741 taggaatttg atatgaaggg tattgttctg gccgggggaa gcggcacgcg tctgcatccc
     7801 gttacgcttt ccgtcagcaa gcaattgctg cccgtttatg ataagccgat ggtttattat
     7861 cccatctccg tgctgatgct ggccggaata cgggaaatcc ttgttatttc cacgccccgg
     7921 gatctgcccc tgtaccggga tttgctgggg gacggcagca ggttcggcgt ttcctttaaa
     7981 tacagggaac aacccaggcc ggaggggctg gctcaggctt ttattattgg agaggagttc
     8041 ataggaaagg attccgttgc cctggtgctg ggggacaata ttttttacgg gcgcggcctg
     8101 acggagaagc tgaggagggc cgccgaactg acgagcggag cgaccatttt cggttaccag
     8161 gtgcatgacc cgcagcgttt cggggtagtg gaattcaatg aggaggggaa ggcggtttcc
     8221 attgaggaaa aaccgcccag gcccaaatcg gatattgcgg tgacgggcct ctatttttac
     8281 gacaaccggg tggtggagat agccaaacgg attcccaagt cttcccgcgg cgagttggaa
     8341 atcacctctg tgaatcagga atacctgaag cagggcctgt tgcgcgtgga aaaactggcg
     8401 cgcggctata cgtggctgga tacgggcacg cacgataccc ttctggaggc ttccatgttc
     8461 gttcgtactc tggagcatca ccaggggttc aaggtagcct gcctggagga gatagccttt
     8521 aataacggct ggatttccca ggaaacgctg cgctcccagg ccggagccat gaataataac
     8581 ggttatggcc gttatctgga tgaattggtg aaatagggct gtctgccgtc ggcgtggaaa
     8641 cgggaggggg ggcctgcgaa cccgcggctt tccggggtgg ggcgggttgc tttccatacg
     8701 gattccgttc caccggcgga aatttccgga cggctttttg cgcaaagccg taaaagcctt
     8761 tcatgccggg gaatgagggt gctcttccgg caggccggta aaaacggagg ggaggaaagt
     8821 cagggacggg tnnnnnnnnn nnnnnnnnnn nnnnnnntcc ggcatggatg ctatggacat
     8881 gacctcttta aacaggcgct gcgccagaat agcggaaagg gccgccagca tgatttccag
     8941 gccgcaggac agaagaacgg ccagccatgc aacaggcgct gccagggagg gaactgcggt
     9001 ggacaggaac tgacgcaaca ggacggcaag aaaaaacagg gcgctctgca aaccgcagcc
     9061 tgccgctgcg atgccccagg ccaggaataa tctcctgcct gcggcaccgt atcccgccgt
     9121 ataagggaag gaaaagaaag aagtgacggc cgacagaagg aggacggcct cccaaaccct
     9181 gtccatttcc gtatattgcg atgggacggg catgcccgca aacggaatga ggagggcgta
     9241 cagggcgggc aggaaggcca gcatgctcag atttcttgtt attctgcttc cgcgggaggc
     9301 cagcagaact ctgacgcccc agaacatgag gaaggacagg gaaaggatgg agagcagttc
     9361 cgcccctgtt cccaaaagca ggaagggcgc ggctgtccgg ggagagcgga ggaaaaaagg
     9421 catgaacaga tggatgagga ctgccgctgc tgcgcccgtg ccgaaaagaa cggagcagac
     9481 tttgatgaaa gccctggctg ccgggtaaat catccagttc atggcgaaga gaagagagta
     9541 gaggggatgg gaaaaaggaa aaggaccgct ccctttgcgg aagcggtcct gaggggttaa
     9601 cgtgaattca tggatgccaa tgcgaatgac ggcatgcgga attacttata ctgggcccag
     9661 tcgacattct tcatgtctcc gcttctggcc agttcggcgt gcatgcccaa agcggccctg
     9721 atggattgcg gtgtctgggc tttgccgtcg gacagcttca ggtaatccca gaggatgttt
     9781 ttgtaatccg ggtggacgca gttttcaata atggtctggg cccgttcttt cgggctcttg
     9841 ccgcgcaggt ccgcgacccc ctgctcggta ataatgatat tgacgtcatg ttccgtatgg
     9901 tcatggtggg aaaccatggg gacgatggcg ctgatcttgc cgtccttggc aacggacggg
     9961 caggtgaaaa tggagatgta ggcgttgcgc gtgaagtcgc cggacccgcc gatgccgttc
    10021 atcatcttcg tgccgccaat gtgcgtggag ttgacgttcc cgtaaatgtc ggcttcaatg
    10081 gcggtgttga tggagatgac gccgagacgg cggataactt ccgggctgtt ggatatttcc
    10141 gagggacgga gcaccagttt gtcgcggaaa aagtccatat ccctgtaaat gccttccagg
    10201 cagtcgttcg tcacggtcag ggagcaggcg ctgccgaatt tcacgcggcc ctcccgaatc
    10261 aggccgatga cggaattctg gatgacttcc gtgtacatct cgaacgcggg aatcgtcttg
    10321 tcgcggccca gggcgcccag caccgcgttt gcgatgtttc ctacgccgga ctggagaggc
    10381 aggaacgtgg agggaatgat gccccgtttc atgtcggcag ccaggaaatc ggccacgttc
    10441 tgcccgattt tatcggtcag gggatccgct gcggcgaagg aacgggcttc atccggccag
    10501 ttggtttcca caacgcccac aatctttttc gggtcaacct ggatgtacgg cttgccgatg
    10561 cggtcgctgg gtttgaagat ggagatttcg cggcggtagg gaggatccag gggttcgtaa
    10621 acgtcgtgca ggcccatggc gctcttgctg tgggcggcgt ttaattccac gataattttg
    10681 tctgccaggc ggcagatggt gggagcgatc ccgcccgcgg ccgtcaggta aattttgccg
    10741 tcggccgtga cttcacaggc ttcaataatg gcgatgtcca cgttgcccat gaacccgtag
    10801 cgcacttcct gggccatctg ggataaatgg atgtcattat aggcgatttc cccgttgttc
    10861 accgccttgc ggaaatcaac gttggtggtg tagggagcgc ggtagcggat tgccttggcc
    10921 cgggaaagga tcccgtcgca ggaatcgcca gtggaagcac cggtgaagac gctcacctgg
    10981 aaagggttcc ccttctcatg ttccgcttct gcgatttttg ccagcgcagc cgtaacggcc
    11041 ttggccgttc cggcgggcgt gaatccgctc agcccaatat ggtggccatg cttgatcagg
    11101 cttgctgctt cttctggtgt cagtaccttg taactcatgt cagtgatttt tgttggatga
    11161 aaaaagaaag aaaccccgtg taaaaacgga gcggcaggct cattcttcga ggagcctgtt
    11221 gatcaggtgc gccggaatgg tgcggacggt gccggccgga agggatagca caggattgcc
    11281 ctgatcgtca atccctgtaa aaatgccccg gacggtttcg tcatccgtaa gaatggaaac
    11341 cggcctttct ccggcccatg cccgggacag cccctcctga agggcgggga cgccgccgtg
    11401 ggaaaagacg gaaagaacct ggttcaaatg actgcccagg gaagccatga cggcgtgcag
    11461 ggaagggcag tcccgaacaa gatccgccag ccttgccgga gggtccttga tttccccggc
    11521 gatggaggat acatcattga aaacattgat gccgatgccg atgacggcca tgttctccgc
    11581 cgggcgttcc accagtattc ccgccagttt ggatttgccc gccagcaggt cgttcggcca
    11641 gcgcaggcgc acggaatcca gccccatgcc gcggagcatg ttgaacaggg ccagccccgc
    11701 aaccaggggc aaatggcccc agtgcacgcc ggccgctgta tcctcaggag cggacagggg
    11761 gacggtgaag gatgcccaca ggccgccttc ctcccctatc catttgcggt tgaacctgcc
    11821 gcggcctcct gtctgaacgc ggcagacggc aatatgcccc ggggggaggg ctcgggccag
    11881 atcattggtg gaaaaagcct cggcccattc atgataagtc cagtcgccgc atggtccttc
    11941 ctcctccgga ggggtggaaa atgaggctgc ggaattcatg ggacgggccg aggccgggag
    12001 taattttcaa ttctggttat ttcgccagag tggcgatgta gtaacccgcg atgactgcgg
    12061 tgccgatcac gcctgcaacg ttcggaccca tggcgtgcat gagcaggtag ttggaggggt
    12121 cgtacttctg gcccacattg tgggagacgc gggctgccat cgggacggcg gagacgcctg
    12181 cggacccgat cagggggttg accggattct tgcgccagat gaggttcata atcttggcgg
    12241 caatcactcc gcccgctgtt gccacgccga aggcgacgat acccagaaga atgatcagca
    12301 gcgtttccga ctgcaggaag cggtcgccct gcatcgtgag ccccacggag gttcccagga
    12361 agatggtgac gatgttgatg atttcattct gggaggcctg aaccaggcgt tccgtcacct
    12421 tgcattcgcg caggaagttg ccaagcatca gcatgccgat cagcggggat gcgtccggaa
    12481 tcagcaaaat ggtgacaatg gttaccagca cggcgaagaa cagtttttcg ctcttgctga
    12541 ccgttcgcag ggatttcatg cggatgaggc gttccttctt ggtcgtcagc aacgccatga
    12601 tgggcggctg tatcagcgga accagggaca tgtacgtgta tgcggccacg gccacggcgc
    12661 ccagcaggtg cggagccagc ttcatcgtca ggaagatgga ggtggggccg tcagcgccgc
    12721 caatgatgcc gatggacgcg gattcattcg gggtgaaccc catgaacagg gccatgaaga
    12781 acgtggcggc tacgcccacc tgggccgctg cgcccagaag cagggtgcgc ggagcggcaa
    12841 gcagcgggcc gaagtccgtc agggctccta ctcccagaaa gatgatgggc gggaaaattt
    12901 cagccttgat gcccagcccg atccagtcat acaggccccc gtggatggag gtgaccagca
    12961 gttcctgggt atgctggcct acggccacgt atttgcctgc ggctgaaacc accaggggct
    13021 ccagcttctg ggttttcaga tccaccggaa tccggttgcc gctggtgtca aagtaattga
    13081 cgccctgctg gcggacgacg gtggtccctt ctccgttcgt gagcagaaag accggttcat
    13141 tgccgttgtc ttccgtcacg ttctggaaat ccttcaggtt ggggtccacc gtcaggctgt
    13201 cgtcgcccag acgggccgcg tcagcttttg ctttttcctg ggattcccgc acggacttga
    13261 tcttggaaac agtcagctgg ctgccggggt aaacctgcat gggctgctgc atgatttcct
    13321 gatactggga acgggattca ggcgtggtca ggttggccgg caccttggag ggagcctgct
    13381 gaagcggagc cacgtgaacg cgcaggtacc ccacgttgtt cagagacgtg gcggttactt
    13441 ccccctgttc attggaggag atgacctgct ggttcagctg ggtgatgagc attccgttat
    13501 ccggaatgtt ggcaatgagg gcgccgaaag caatgggaac catcaggagc ggttcgtatt
    13561 gcttggctac acccagatac aggaggagaa tggcaatgcc ccacatccct accatctgcc
    13621 atgataggga gaagacgccc atcccctgta aaaaggtgat taatgaatca aaaagactca
    13681 tagggaatat ttttgtagc
//
