LOCUS       c00040_gnlPro..        14528 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ALINBPNL_40.
ACCESSION   c00040_gnlPro..
VERSION     c00040_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 10:34:10
            Original ID  :: gnl|Prokka|ALINBPNL_40
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 14723
            Orig. end    :: 29251
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14528
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[24723:29249]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14526
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14528
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14528
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             794..1870
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_11"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 1e-09, bitscore:
                     28.7, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMMKRELHTFIIGSVLFFTACGDKQESEQKSGYRIQGDTVYIADP
                     LLLEKIKVSVSELKPYSKKVITSGVVRPIPPRYAYVAPPFAGRVTKSYVRIGQSVRQGT
                     PLFEISSPDFTSAQKEYFQALSSRELAKKDLKRKEDLIRNGVSSQRELEEAQNALLIAD
                     KEFENASAALRVYQVDNPAEMILGQPMIVRSPIPGEVIKDNIVTGQYLKDDTEPIAIVA
                     DLSKVWIAAQVKEKDIRFINEGSSLDIEISALPGTVIKGNVYHVEEEVDEETRSIQVLS
                     VCDNLNGHLKLGMYTTVHFLSVPVGQIQIPEKTLLQGEKDSYVFVQIAPLVFVRTSVTV
                     ETTENGIAVISDCVPEIR"
     CDS             1906..5013
                     /locus_tag="ctg40_12"
                     /transl_table=11
                     /translation="MKKELMLSIIQKRWVMLCLFVMMCIFGYYSWKQLSIEAYPDIADV
                     TSQVVTQVPGLAAEEVEQQITIPLERAINGLPGMHVMRSKSTFGLSMITIVFKDGTEDY
                     WSRQRVQERLNEVELPYGAVPGLDPLTSPVGEVYRYIIESDQHSLRELTDLQNWVIIPR
                     IKEVSGVADVTNFGGITTQFQVEVDPSKLEQYNLSLSQVVEAIENNNANVGGSVLNRGD
                     LGYVVRGIGLIGNLDDLGHIVVSTTSGVPVFLNDIGSLKYGNLERKGVLGYTDRTRNYS
                     ESLEGIVLLLKHENPSKVLEDIHVAVDELNNETLPEGVRIHTFLDRTNLVDTTLSTVSH
                     TLLMGMALVVLVLILFLGNWRGALLVSITIPVSLLIAFILMHLTDIPANLLSLGAIDFG
                     IIVDGAIVMLETILKKREDNPKQYLEEKSMAQRAKEVGRPILFSTIVIITAYLPLFAFE
                     RVERKLFTPMAFTMSYAMIGALLVALLLIPGLAYAIYRKPHKIYKNKWLDRLKDKYIRT
                     ITGFLEAPLKAIIPSGLILTAGIVLSVVVGKDFLPELDEGSIWLQVNLPPGISVEKSRE
                     LSDTLRARTMKYSEVTYIMVQAGRNDDGTDPFTPSHFEVSIGIKPYDEWPKGKTKKDLI
                     HELEEEYKLLPGFKVGFSQPMIDGVMDKIAGAHSELVVKVYGEDFRETRRIAEEITRAL
                     GTVRGAVDLDIDQEPPLPQLQISMNRDAIARYGLNVSDVADLIEVAVGGKAIAQLYQGD
                     RQYGITCKYKEEARNTPEKIAGLMLTSSTGAKIPLSQVADVRLSVGESTITREMNRRHL
                     TVKLNLRGRDLTSFLNEAQNTINEKVHYDKNKYTIKWGGAFENQKRAYTRLAVIIPLTL
                     TGMFILLYVTFGKFRQAGLVLAIVPLALFGGMLALNVRGMTLNVSSAVGFIAMFGLSIQ
                     NGIIMVSQVNGLRRGGMELRKSVIEGARQRFRPILMTSVTTILGLFPASLATGIGSDVQ
                     RPLATVIVYGLMFSTLISMFLLPAFYYLVENNVLNKKKNDEKEYTI"
     CDS             4991..5980
                     /locus_tag="ctg40_13"
                     /transl_table=11
                     /translation="MKKNIRYNIVLLLLMVEAVLIPTFAQMPEIKQGQSISFEEYLNRV
                     GKKNLSYLAEKLNVSIADAEVIARKIFPDPELEFEAGNETFSLGVSYSLEMGNKRGARI
                     KLARTQAELEKLFLQQGFQDLRAEAADLFLEAILQRELLEVQKSSYEYMYQLSQSDSLR
                     YVSGEITENDVRQSKLETVTLLNTVYSQEAAYHSALVLLNKHMGMSADTLHIPLGNWEE
                     LSRDFALSDLVKAGLDNRIDLLVAQKSTEVTTREYKLTRAERRPDIGVSVSYERNWNGF
                     LPPSRSATAGVSVPLTFSNINKGAVKAAKFRIAQSEIMERDMELQIQR"
     CDS             6574..7341
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_14"
                     /sec_met_domain="Acetyltransf_1 (E-value: 6.2e-08,
                     bitscore: 23.4, seeds: 223, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAKYITLTKENIEKEHICCAFSDKKCKDSYELKKTWLKNEFENG
                     YVFRRLDERAKVFIEYGPAEKAWVPVNAPNYLMINCFWVSGKYKGCGHGKALLQSAVED
                     AKAQGRDGLVTVVGTSKFHFMGDAKWLLRQGFETIEKLPYGFSLLALKINPAAPDPSFN
                     GTVSSGECEEKEGVVVYYTHRCPFAEFHVRNSLVSVTENKGIPLKIVRLETMAQAQNAP
                     TPATIFSLFYKGKFVTTDLSACMEQRFDKALGL"
     CDS             7720..9489
                     /locus_tag="ctg40_15"
                     /transl_table=11
                     /translation="MKSIRSVICFCLFLFVFNQLLFADKTIENDSLYTSEYISRIYMAE
                     PERALSLLDGAESKKTIPLRIIHELRSRVYRNMYMTKLAFLYAKKSYLLDSVSQKDTKH
                     LLTMTVDLAELAVLMSDHKESMRYALDGIKLAQKEKDKGAESKLLFCIGENKWQLSFKE
                     EAYDYFDKAIKLLQGTSSKLEMAMLSYFYGMKMDYLLNDSRSKEALEVGLKREKLLKDI
                     AKLPEKTKGFLDLQYTYLYAKMSYICYLEGKYDQAEKYYQQYLSTENSQTPDGKTYAIP
                     YLLVSKQYQKVVDQCQDFKKLMQEQDTVNLQYISILQKEVKAYKGLKDFEKVAALRESI
                     ISIIDGINSKDKQNAALELNAIHKADEQEEYIAEQTLQLRIRNISLAFLGCVTCLILFV
                     LWRIWRHTIIVKYKNKMLAKFINEKLAGKVENKQLFIDGDAEDPIAVPLDLEPETGFSE
                     KDDLSPDEVVESREEEDENKKIFKELNRIVVQDQLYLSPELSREDLAQIVHLNNARFAR
                     MIKENTGTNFNGYINELRINYAIQLLKQHPNYTIRAIADEAGFNSTPILYSMFKKKTGM
                     TPYEFKKAQESLG"
     CDS             9560..9922
                     /locus_tag="ctg40_16"
                     /transl_table=11
                     /translation="MVQVRIKRVYEDFSETDGYRVLVDKLWPRGIKKEWLKYDYWAKDI
                     TPSAALRRWFHEDIPGHWNDFVVMYQKELEASQAVADFLTLIKPHLVITLLYASKEPVY
                     NHARILRDYLEMHLKE"
     CDS             10001..11239
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_17"
                     /sec_met_domain="HBT (E-value: 3.8e-17, bitscore: 53.0,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VSMKYKLLVLDVDGTLLNDAKEISKRTLAALLKIQQMGVRIVLAS
                     GRPTYGLMPLAKSLELGNYGGYILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARK
                     NNFALFTYHDDTIITDTPENEHIQNEARLNNLKVIKEEEFSVAIDFAPCKCMLVSDDEE
                     ALVSLEGHWKRRLNGALDVFRSEPYFLEVVPCAIDKANTLGALLEELDVKREEVIAIGD
                     GVCDVTMIQLAGLGVAMGHSQDSVKVCADYVTASNEEDGVALAVEKAIIAEVRAAEIPL
                     DQLNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALGETVAGL
                     GSMILCQPDEIVVGMQVSGNHISSAHEGDTVRAVATIVHKGRSSHVWNVDVFTSTNKLV
                     SSIRVVNSVMKKR"
     CDS             11236..12348
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_18"
                     /sec_met_domain="Chorismate_bind (E-value: 5.5e-58,
                     bitscore: 186.9, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDEKSNLTTIDALIQRKQPFAVYRVPGEKYPRLLTEDVGAVRLI
                     FDLKELNGQRGFVIAPFRVDKSCPIVLIQSDRTGQPLPMEIVAEEEQGLQSYPEESFHT
                     LCTGKYATCFHTFIEALRDATFDKLVLSRSLTIGKNPEFSPSAVFRAACQRYIHSYIYL
                     CYTPQTGVWLGSTPEIILSGEKNEWNTVALAGTQPLQNGKLPQVWDDKNRQEQDYVASY
                     IRRQLLSLGIRSTESGPYPAYAGALSHLKTDFHFSLKDNKNLGDLLKVLHPTPAVCGLP
                     KEEAYRFILENEGYDRKYYSGFIGWLDPEGRTDLYVNLRCMHIEDEQLTLYAGGGLLAS
                     SELNDEWQETEKKLQTMRRILVSAPIMMNH"
     CDS             12368..13324
                     /locus_tag="ctg40_19"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLEAHGITKVVLCPGSRNAPIVHTLSTHPGFT
                     CYAMTDERSAGYFAIGLALNGGHPAAVCCTSGTALLNLHPAVAEAYYQNIPLVVISADR
                     PAAWIGQMAGQTLPQPGVFQTLVKKSVNLPEIQTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINIPISEPLFQFTVESLPEVRVITRYQGLNVYDRDYNDLIERLNRYQKRMIIVGQMN
                     LIYLFEKRHTKLLYKHFVWLTEHIGNQTVPGIPVKNFDAALYAMPEEKTGQMTPELLIT
                     YGGHVVSKRLKKYLRQXXXXXXXXXXXXXXXLTFTVL"
     CDS             13339..14034
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_20"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.3e-09, bitscore:
                     28.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDPFEFLEKIAPLLDNRVPEYPRVWENYCKTIPEPEFGYSEMSAI
                     GALIKALPESCALHLANSSVIRYAQLYQVPSTIEVCCNRGTSGIEGSLSTAVGYAAGSD
                     KLNFIVIGDLSFFYDMNALWNINVRPNLRILLLNNGGGEIFHTLPGLDMSGTSHKYITA
                     VHKTSAKGWAEERGFLYQRVENEEQLAEAMKTFTQPEAMEQPVLMEVFSNKNKDARILK
                     DYYHQLKQK"
     CDS             14038..14526
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_21"
                     /sec_met_domain="ECH_1 (E-value: 1.7e-46, bitscore: 149.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYEDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     "
ORIGIN
        1 aagggtttct ttatttaatg taccttttgc aggaaatgcg gcttcaagtg cagactacgc
       61 tacagctttt actactcctt ttggtggaac tggtaataca ggtcctggga catatcctta
      121 cggagcaaac aaagatatgc ttgcccggaa acaactaaaa ggaacaactt atacatttta
      181 ttcggacgga tttttcgaca gacgtccgat aaaagaggct tcgaatggaa actatggcgt
      241 atcattagga aatagtaatg ttgcttatca gggagtattg tattttaatc ccgattccgg
      301 aacgaatgca tctgtctttt ttccgtcagc cggtcgtctg aataacacaa gtggtgcttt
      361 ggaaagtagg ggtagtaccg gatactattg gtcggcaagt gtaggtcctc cttatatgag
      421 atcggaattg cagaatccac cttatgacag gagaatacgt tatggagcct ggtcgcttga
      481 gtctgcatat aattctcata atttcagatt gtcatatcaa ggttttgctc aaagtatacg
      541 ttgtgtgaaa gaataagaac ttttcggctt acgataaaaa taccggaata tcatccgttg
      601 aggggttggc tttttagtca accccttatt tgtgcgtact ctctaacaac aaaactgctg
      661 ttttaagaag aaatctttat ttactctaat aagattctaa taggattcta actattctct
      721 aacaggctct ccgaagggag ccgtctatct ttgtgcccgg aaatccggtt actaacttaa
      781 cttatgttta attatgatga tgaagagaga gttacacaca tttattattg gcagtgtgtt
      841 gttttttacc gcatgcgggg ataaacagga atcagagcaa aaaagtggct atcgtataca
      901 aggtgacacg gtctatattg cagatcctct tttacttgaa aagatcaaag tatcagtgtc
      961 tgaactgaaa ccctattcca agaaggtgat aacgtccggt gtggtgcgtc ccattcctcc
     1021 ccgttatgct tatgttgctc ctccatttgc agggagagtc acaaaatctt atgtgcgtat
     1081 cggacagtcg gtacgtcagg gaacaccttt atttgaaatc agttcccccg actttacttc
     1141 tgcacaaaag gaatactttc aggcactttc gtccagggaa cttgctaaaa aagatttgaa
     1201 acgcaaagaa gatctgataa ggaatggtgt cagttcgcaa agagaactgg aagaagccca
     1261 gaatgcttta ttgatagcag ataaggagtt tgaaaacgcc tctgccgcat tgcgggtata
     1321 tcaggtggac aatccggcgg aaatgatatt ggggcaaccg atgattgttc gttctcctat
     1381 tcccggggaa gtgataaagg ataacatcgt aacagggcaa tatctgaaag atgataccga
     1441 accgatagct attgttgccg acctgtctaa ggtatggatt gcggctcagg taaaggagaa
     1501 agatatccgg tttataaatg aaggcagtag tctggatatt gaaatttcgg cattgcccgg
     1561 tacggttatt aaaggcaatg tgtatcatgt agaggaggag gtagacgagg aaacccggtc
     1621 cattcaggta ctttcggtct gtgataattt gaacggacat ctgaagctgg ggatgtacac
     1681 tactgtccac tttctgagtg ttccggtcgg acaaattcaa atcccggaga aaacgttact
     1741 acagggcgaa aaggatagct atgtatttgt gcagattgct ccgttggttt tcgtacggac
     1801 gtcggtgaca gtggagacaa cagaaaacgg aatagcggtg atcagcgatt gcgtcccgga
     1861 gataagataa tcagtgaagg aggatattat ttaaagtaag aaattatgaa gaaggaatta
     1921 atgctttcaa ttatacaaaa aagatgggta atgctttgcc tgtttgtgat gatgtgtatc
     1981 tttggatatt actcatggaa acagctttcg atagaagcat atccggatat tgcagatgtc
     2041 acttcccagg tggtcactca agttcccgga ctggctgcgg aggaagtgga acagcagata
     2101 accattcctt tggaacgcgc tattaatggg ctgcccggta tgcacgtcat gcggagtaag
     2161 agtacattcg ggctgtcaat gattaccatt gtctttaagg acgggacaga ggactactgg
     2221 agccgccagc gcgtacagga aagattgaat gaagtagaac tgccttatgg agctgttccg
     2281 ggacttgatc cgctgacatc tcccgtagga gaagtgtacc gttatatcat agaaagtgac
     2341 cagcactcat tacgcgaatt aaccgacctt cagaactggg taattattcc ccgtatcaag
     2401 gaagtgtcgg gagtggctga tgtaaccaat ttcggtggga tcactactca gttccaggtt
     2461 gaagtagatc cgtccaaact ggaacaatat aatttatctc tcagccaggt tgttgaagcc
     2521 attgagaata acaatgccaa tgtgggggga agcgtgttga atcgtggtga cttgggttat
     2581 gtggtacggg gaattggatt aatcggaaat ttggacgatt tgggacatat tgtagtgagt
     2641 actacttccg gagttcctgt ctttctgaat gatataggtt ctttgaagta tggaaatctt
     2701 gaaagaaagg gagtgctggg atatacggac cgtacccgca actactctga gagtctggaa
     2761 ggaattgtac tccttctgaa acatgagaat ccgtctaaag tactggaaga tattcatgtg
     2821 gcagttgatg agttaaataa tgagacattg ccggaaggag tgaggataca tacttttctg
     2881 gatcgtacca acttggtgga tactactttg agtaccgtat cccatacctt gctgatgggt
     2941 atggctttgg tggttcttgt gcttattctg tttctaggca actggcgtgg tgcattattg
     3001 gtatctataa cgattcctgt gtcattgctt atcgctttta ttcttatgca tctgacggat
     3061 attccggcta accttctgtc gcttggtgct attgatttcg gtattattgt ggacggcgct
     3121 atcgttatgc tggaaacgat ccttaagaaa cgtgaggata atcccaaaca atatctcgaa
     3181 gaaaaaagca tggcgcaacg cgccaaagaa gtgggtcggc ctattctttt ctcaaccatt
     3241 gtcattatta cggcatacct tccgctgttt gcctttgaac gtgttgaacg caaacttttt
     3301 actccaatgg catttacgat gagctatgca atgattggag cactgttggt tgcgctctta
     3361 ttgattccgg gacttgccta tgcaatctat cgtaaaccac ataaaatata taagaataaa
     3421 tggctggaca gactaaagga taaatacatt cgtaccatta caggatttct ggaagctccc
     3481 ttaaaagcca tcattccatc aggactgatt ctgacagcgg ggatcgtgtt gagtgttgtc
     3541 gtaggaaaag acttccttcc ggagctggat gaaggttcga tatggttaca ggttaatctg
     3601 ccacccggaa tttccgtaga aaagtcacgg gagttatctg atactttgcg tgcccgtacg
     3661 atgaagtatt ccgaagtaac ttatattatg gtacaggcgg gaaggaatga cgacggaact
     3721 gatccgttca ccccttcaca ttttgaagtg tccatcggta ttaagcctta tgatgaatgg
     3781 ccgaaaggaa aaactaaaaa ggatttgatt catgaactgg aagaagaata taagttactt
     3841 cccggtttta aagtaggatt tagccaacct atgatagacg gggtgatgga taagatagcc
     3901 ggggcccata gtgaactggt ggtgaaagta tatggcgaag attttcgtga aacacgtcgt
     3961 attgccgaag aaataaccag ggcattagga actgtgcgag gggctgttga tctggatatt
     4021 gatcaggaac cacccttgcc acagttacag atcagtatga atcgtgatgc catagctcgt
     4081 tacggattaa atgtatccga tgtagcggat ctgattgaag tggctgtcgg aggtaaagct
     4141 atcgcacaac tttatcaggg tgaccgccag tatggcatca cctgtaagta taaagaggaa
     4201 gcgcggaata ctccggagaa aatagccgga cttatgttga cttcttccac cggtgcaaag
     4261 atacctcttt ctcaggttgc cgatgtcaga ttgagtgtcg gcgaaagtac gattaccagg
     4321 gaaatgaaca gacgccattt gacggtaaag ctgaatttgc gcggtcgtga cctgacatct
     4381 tttctgaatg aagcccagaa tacgatcaat gagaaagtac attatgacaa gaataaatat
     4441 accatcaaat ggggaggggc cttcgaaaat caaaaacggg cttatacacg tcttgctgtc
     4501 attataccgc tgacactgac agggatgttt atactgcttt atgtcacgtt cgggaagttc
     4561 cggcaggcag gactggtatt ggctattgtt cctctggcac ttttcggagg tatgcttgct
     4621 cttaatgtgc gtggtatgac gctgaatgta tcttctgccg taggatttat agcgatgttc
     4681 gggctttcca tacaaaatgg aattatcatg gtatcgcagg tcaatgggct gcgcagggga
     4741 ggaatggaac tccggaaatc ggtcatagaa ggggcacgcc agcgtttccg acctattctg
     4801 atgacttcgg tcactacgat actcggactt ttcccggctt cgttggcaac cggaattggt
     4861 agtgacgtac agcgtccgct ggcaacagtg attgtgtatg gattgatgtt ttcaaccctt
     4921 atctctatgt ttctgcttcc ggctttctat tatctggttg agaacaatgt tttaaataaa
     4981 aagaagaacg atgaaaaaga atatacgata taatatagtg ctcttgcttt taatggtgga
     5041 agccgtactc attccgactt ttgcgcaaat gcctgaaata aagcaggggc agtctatttc
     5101 tttcgaagaa tatctgaatc gggtagggaa aaagaacctg agttatttag ccgaaaaact
     5161 caatgtgagt attgctgatg cggaagtaat tgcccggaaa atctttccgg atccggagtt
     5221 ggaatttgaa gcaggtaatg agactttctc gttgggagtt tcctattcat tagaaatggg
     5281 aaataaaagg ggagcacgta ttaagttggc gcggactcag gcagaattgg agaaactgtt
     5341 cctgcaacag ggctttcagg atttgagggc ggaggctgcc gacctttttc tagaagcaat
     5401 tcttcagcgc gaattacttg aagtacagaa aagttcttat gagtatatgt atcagctgag
     5461 tcagtcagat agtttacgtt atgtttcggg agagattacg gagaatgatg tccggcagtc
     5521 aaaactggaa actgtcacct tgcttaatac tgtttacagt caggaggcgg cttatcattc
     5581 cgctttggtt ttgttgaata aacacatggg gatgagtgct gatacgcttc atatcccttt
     5641 gggaaattgg gaagagctaa gcagggactt tgctctgtct gatttggtca aagcgggact
     5701 ggataatcgc atcgacctgc ttgttgctca aaaaagtact gaagttacta cccgggaata
     5761 taaactgacg agagcggaac gcagacccga tatcggagta tctgtttctt atgaaagaaa
     5821 ctggaacggc tttcttcctc cgtcccgttc tgctactgcc ggtgtatctg ttcctctgac
     5881 attctcgaat ataaataaag gagctgtaaa agctgcaaag tttcggattg cccaatcgga
     5941 gataatggaa agagatatgg aattgcagat acagagataa cccaggcctg gttcaactat
     6001 gaggctgaaa agaaaaagat agctcaatat aaagccggtg tacttgaaga ctcgcagaag
     6061 gtgctcgacg gaatggtata taaatacaaa cggggagaaa cgagtattct tgatgtactg
     6121 gttgcccagc gtacttataa tgaagtgcaa caggagtatc tggaaacaat gaaaggatat
     6181 gccgcttcac tagtagcatt ggaaagagct tgtggtatat gggatatatg cttttgacag
     6241 ttaaatatcc ggctttacta ttgtgaattg cagcaaagcc ggatatttgt atggttacca
     6301 gtcagcggtt tcacgcttta tgttaaatca ttgtgcgata ttcctcctgt tttttcttag
     6361 ggagtttttt tgatcacttc ttccacagag tggtcaataa gttctttgat aagtttgtca
     6421 ctcaggttta tttacttatc tgttttccga actttaatcc gtactactgt gtcattttga
     6481 cgagactgga caatgtttta ttactttcga ttgtgtatct ttgctgtagt tgaaatggac
     6541 aaccggaatt tatatactaa taaacagaat attatggaag cgaagtatat cactctgact
     6601 aaagagaata tcgaaaaaga acatatttgc tgtgctttct ccgataagaa atgtaaggat
     6661 agctatgagt tgaaaaagac atggctgaaa aatgagtttg agaatggcta tgttttcaga
     6721 cggcttgacg aacgtgcaaa agtatttata gaatatggac ctgccgaaaa agcttgggtt
     6781 ccggttaatg cacctaacta tttaatgata aactgttttt gggtttcagg aaaatataaa
     6841 ggatgcgggc atggcaaagc actattgcag tctgctgtcg aggatgccaa agcacagggt
     6901 agggatggct tggtgactgt ggtcggtacc tctaaatttc attttatggg tgatgcgaaa
     6961 tggttattac gtcaggggtt tgagacgata gaaaaactac cctatggttt cagtcttttg
     7021 gctttgaaga taaatccggc agctcctgat ccgtcattca atggaacagt atcaagtgga
     7081 gaatgtgagg aaaaagaagg tgtagtcgtt tattatacac atcgttgtcc gtttgcagag
     7141 tttcatgtcc gtaattcttt agtgagtgtg actgagaaca aaggtattcc attgaagata
     7201 gtcagattgg aaacgatggc acaagcacaa aatgcaccta cacctgctac tatcttttct
     7261 cttttctata aaggaaagtt tgtaacgacg gatttgagtg catgtatgga gcaacggttt
     7321 gataaagcgt tgggattata atctttctta ttacagtatg tgtttctctt ttttgatttt
     7381 ctgtttttgt gctgttttgc tctgatgagt gtggcgggtt aataattgtc tggtgtttat
     7441 ttagactggt cggttcgatt tttcatgtgc tgctctgatc ttatgcagat tcattaatag
     7501 aatcggcagt ttatttatat gttgagatgt tttgttttat gtatgtgaca tatgcttgat
     7561 ttttagtatt ttattgtatg tggttggtgg ggaaaacttg atagctcctg acttttataa
     7621 tcactaactt ttcttatttt agttcattca aatatgttca attcttgcat tttatgaaac
     7681 tatgttttac ttttggggag taaaatcatt gggattataa tgaaaagtat tcgctcggtt
     7741 atttgttttt gtttgttttt gtttgtgttt aaccagctcc ttttcgccga caaaactata
     7801 gagaatgatt cgctatatac cagtgagtat ataagtcgaa tttatatggc agaacctgaa
     7861 cgggctttaa gtttgttgga tggagctgaa agtaagaaga ctatccctct gcgtattata
     7921 catgaattac gcagcagggt ttatcgtaat atgtatatga ctaaactggc ttttttgtat
     7981 gccaaaaagt cttatttgct ggattccgtt tctcagaaag atactaagca cttgttgacc
     8041 atgactgtcg acctggcaga attagcagtg cttatgagtg accataaaga gagtatgagg
     8101 tatgctcttg atggtatcaa gctagcacaa aaagaaaagg ataaaggggc tgaaagtaag
     8161 ctgttgtttt gcattggtga aaataaatgg caattgtctt tcaaagagga ggcatatgac
     8221 tattttgaca aagctatcaa attgcttcaa ggtacaagtt ccaaattgga aatggctatg
     8281 ctttcatact tttatgggat gaaaatggat tatctgctca atgattcccg tagtaaagaa
     8341 gcattggagg ttgggttgaa gcgcgaaaag ctacttaaag atatagctaa attaccggaa
     8401 aaaacaaaag gctttcttga tctgcaatat acttacttgt atgcaaaaat gtcgtatatc
     8461 tgctatctgg aaggaaagta tgatcaggcg gaaaaatatt atcaacaata tttgtcaaca
     8521 gagaattcac agacaccgga tggaaaaacc tatgcgatac cttatctgct agtgtctaaa
     8581 caatatcaga aagtcgttga tcaatgtcag gattttaaga aattgatgca agagcaggat
     8641 actgtcaact tgcagtatat tagtatcctt cagaaagagg tgaaagctta taaaggcttg
     8701 aaggattttg aaaaagtagc agcattacgt gagtctatta tttctattat tgatggtatt
     8761 aacagcaagg ataaacagaa tgcggctttg gaattaaatg ctattcataa agctgacgag
     8821 caggaagaat atattgccga acagacttta cagttaagaa tcagaaacat atcacttgct
     8881 tttttgggat gtgtcacttg tctcatttta tttgtgctat ggcggatttg gcgtcatacg
     8941 attattgtta aatataaaaa caaaatgctg gcaaagttta tcaatgagaa actggctgga
     9001 aaagtagaga acaaacaatt attcatagat ggagatgcgg aagatccgat agctgttcca
     9061 ttggacttgg aaccggaaac tggcttttcc gaaaaagacg atttatctcc ggatgaagta
     9121 gtggagagta gggaggaaga ggatgagaat aagaaaattt tcaaagaact gaatcgtatt
     9181 gttgttcagg atcagttata tctgtctccg gaattgtcga gagaggatct ggctcagatt
     9241 gtacatttga ataatgcgcg tttcgcccgg atgatcaagg aaaacaccgg aactaatttc
     9301 aacgggtata ttaatgaact tcgtattaac tatgcgattc agttattgaa gcaacatccc
     9361 aattatacca ttcgtgcgat agctgatgaa gccggattta atagtacgcc tattctgtac
     9421 agtatgttca agaaaaagac tggtatgact ccttacgaat ttaaaaaagc gcaggaatcc
     9481 ttaggttgat tttggctttt tcgataaaca attttccgtt ttatcggttt attcttatga
     9541 taactaaata taaacggaaa tggtgcaagt taggataaag cgagtgtacg aagacttttc
     9601 agagaccgac ggatatcggg tgctggtaga taaactctgg ccacgtggaa tcaaaaaaga
     9661 atggttgaaa tatgattact gggcaaaaga tataacgcct tccgcagcac tgcgcagatg
     9721 gtttcatgaa gatattccgg ggcactggaa tgattttgtc gtaatgtatc agaaggaact
     9781 ggaagcttct caagctgttg ccgattttct gactcttatc aaacctcatc tggtgatcac
     9841 tttgctttat gcatccaaag aaccggttta taatcatgcc cgaatccttc gtgattattt
     9901 ggaaatgcat ctgaaagagt gaaattaaag taatttttat ctctttccgc tttcagtcgt
     9961 tcactcaatt tcctaccttt gtaatctaaa tcaaaatcgt gtgtccatga agtataaatt
    10021 attagttctt gatgtagacg gaacgcttct caatgatgca aaagaaatta gtaaacgtac
    10081 actggccgcc ttgctgaaaa tacagcagat gggagtacgt atcgtgttgg catccggccg
    10141 accgacttac ggtctgatgc ctttagccaa atccctagaa ctcggaaatt atggaggtta
    10201 tatcctttct tataatggtt gccagataat taatgctcaa aacggagaaa tactgtttga
    10261 gcggaggatt aatccggaaa tgttgcctta tctggaaaag aaggcaagaa aaaataattt
    10321 cgcactgttc acttaccatg atgatacgat cattactgac actccggaga atgaacatat
    10381 ccagaatgaa gctcgcttga ataatttgaa agtgatcaag gaagaggaat tttctgtagc
    10441 aattgacttt gctccgtgta agtgtatgct tgtcagcgat gacgaggaag cgttggttag
    10501 tctggaagga cactggaaga gacggttgaa cggagctttg gatgttttcc gttccgaacc
    10561 ttattttctg gaagtagtgc cgtgtgcgat tgataaagcc aacacattgg gagctttatt
    10621 ggaagaactg gatgtgaagc gtgaagaagt catcgctata ggagacggtg tgtgcgatgt
    10681 aacgatgatt cagctggcag gactgggagt ggcgatgggg cattcgcagg attcggtaaa
    10741 ggtctgtgcg gattatgtga cagcttccaa tgaggaagac ggagtggctc tggctgtcga
    10801 aaaggcgata atagcggaag ttcgcgctgc agagattcct ttggaccagt tgaatgcaca
    10861 ggcgcgtcac gcattgatgg gtaatctggg tatccaatat acatatgccg acgaagaccg
    10921 tgtagaggcg acgatgccgg tagatcaccg tacccgtcag ccgttcggta ttttgcacgg
    10981 tggagctacg cttgcattgg gagaaacagt tgccggactc ggctcgatga ttctctgtca
    11041 gccggatgaa attgtggtag gaatgcaggt cagcggaaat catatatctt ctgcgcacga
    11101 aggtgataca gtacgtgcag tagcgacgat tgtacacaaa ggacgttcct cccatgtatg
    11161 gaatgtggac gtttttactt caaccaataa actggtgtcc tctatacggg tggtcaacag
    11221 tgtgatgaaa aaaagatgat tgacgaaaaa agtaacttga caactattga tgcacttatt
    11281 cagcggaaac agccctttgc tgtttatcgt gttcccgggg agaagtatcc tcgtctgttg
    11341 acagaagatg tcggagctgt ccgcctgatt ttcgatttga aagaactgaa tggacaaaga
    11401 ggatttgtga ttgctccgtt ccgtgtagat aagtcatgtc cgattgtgtt gatacagtcc
    11461 gacaggactg gacaaccgtt gcctatggaa atcgtggcag aggaagagca gggcttgcaa
    11521 agttatccgg aggaatcttt tcataccctt tgtactggga agtatgcgac ctgttttcat
    11581 acatttattg aagccttgcg tgatgctacc tttgataaac tggtgctttc ccgtagtctc
    11641 actattggaa agaatccgga gttttcccct tcagctgttt ttcgtgcagc ttgtcaacgt
    11701 tatattcatt cctatatcta tctgtgttat actcctcaga cgggcgtgtg gctgggaagt
    11761 actcccgaaa ttatattgtc gggtgaaaaa aatgaatgga acacagttgc cctggcagga
    11821 actcaacctt tgcagaatgg taaacttccg caagtatggg atgacaaaaa ccgtcaggag
    11881 caggattatg tggcgtccta tatccgtcgg cagcttcttt cgctgggcat tcgctccaca
    11941 gagagcggac cttatccggc ttatgccggt gccttgtcac atctgaaaac tgatttccat
    12001 ttctctttga aagataataa aaatctggga gaccttctga aagtcctgca tccgactcct
    12061 gccgtgtgcg gactgcctaa agaagaagcc taccggttca ttttggaaaa tgaagggtac
    12121 gatcgtaagt attattccgg ttttatcggt tggctcgatc cggagggacg cacagatttg
    12181 tatgtgaatc tgcgttgcat gcacattgaa gacgagcaat tgacactgta tgccggtggc
    12241 ggattgttag cctcttcaga gttgaatgat gaatggcagg aaacggaaaa gaaattgcag
    12301 accatgaggc gtattcttgt atctgctcca ataatgatga atcactaaca agctaatcac
    12361 tatcaatatg tattcggaca agaaaaatat actccagttg gtcgcgctgc ttgaggcgca
    12421 tggaattacg aaagtagtgt tatgtcccgg tagccgtaat gcacctattg tgcatacgct
    12481 gtctactcat ccgggtttta cttgttatgc tatgacggat gaacggagtg ccggttattt
    12541 tgcgattggt cttgcgctga atggcgggca tcctgctgcc gtttgctgta cttccggtac
    12601 agcgttgctc aatcttcatc ctgctgtggc agaagcgtat tatcagaata tacctttagt
    12661 tgttatctct gccgatcggc ctgctgcctg gattggacag atggcgggac agacattgcc
    12721 gcagcccggt gtttttcaga cattggtcaa gaagtcggta aaccttccgg agattcagac
    12781 agaagaggat gaatggtact gtaaccgctt ggtgaatgaa gccttgctgg aaaccaacca
    12841 tcatggaaaa ggtccggtac atattaatat tcctatatcc gaacctttgt tccagtttac
    12901 ggtggagtcg cttcccgaag tacgtgtcat tacgcgctat caggggctga atgtatacga
    12961 ccgggattac aatgacctga tcgaacgctt gaacagatat cagaagcgga tgattattgt
    13021 cggacagatg aacttgattt acttgtttga gaaacggcat accaaattgt tatataaaca
    13081 tttcgtgtgg ctgaccgagc atatcggtaa tcagacagta cccggtattc cagtgaagaa
    13141 ttttgatgcg gcgctttatg cgatgcccga agagaaaacc ggccagatga ctcccgagtt
    13201 attgattact tatggcggac atgtggtttc caagcggttg aaaaaatatc ttcggcagnn
    13261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nggttgacct ttacggttct
    13321 ctgactaccg tcatcgaaat ggacccgttt gagtttctgg agaaaatagc tccattgctg
    13381 gataaccgcg tgccggagta tccccgtgta tgggagaatt attgcaagac cattcccgaa
    13441 ccggagttcg gatattcgga aatgtcggct atcggtgctt tgataaaagc attgccggaa
    13501 tcatgtgcat tgcatctggc aaatagttct gttatccgct atgctcagtt ataccaggtt
    13561 ccttctacga ttgaggtatg ctgtaatcgg ggtacaagcg gcatcgaagg ctcgttgtcc
    13621 acggcagtgg gatatgccgc cggttcggat aaactaaatt ttatagttat aggtgacctt
    13681 agtttctttt atgatatgaa tgctttgtgg aacatcaatg tccgtcccaa tctacgcatt
    13741 cttttgctga ataacggagg aggggagatt ttccatacat tacccggact ggatatgtcg
    13801 ggtacatcgc acaagtatat tacagccgtt cacaagacat ctgccaaagg atgggcggaa
    13861 gaacgcggat tcctttatca acgggtagag aatgaagaac agcttgccga agcgatgaaa
    13921 accttcacac aaccggaagc catggaacaa ccggttctga tggaagtatt cagcaataaa
    13981 aataaagatg cacgtatact gaaagattat tatcatcaac taaaacaaaa atagattatg
    14041 tcaacacaaa gagaatggac aaccatcaga gaatacgaag atatcctctt tgattactat
    14101 aatgggattg cccgcatcac cattaaccgt gaacgctatc gaaatgcatt tactccgact
    14161 acaacggctg aaatgagtga cgcattgcgc atttgccggg aagaagcgga tattgatgtg
    14221 atcgtgatta cgggagctgg tgacaaggct ttctgttcgg gcggtgacca gaatgtgaaa
    14281 gggcgtggcg gctatatcgg caaggacggt gttccccgtc tgagtgttct ggatgtacag
    14341 aaacaaatcc gcagcattcc gaaaccggta attgctgccg taaatggatt tgccattggt
    14401 ggcggacacg tgcttcatgt agtttgcgat ttatcgattg cttcggagaa tgcgatcttc
    14461 ggacagaccg gtcctcgcgt aggtagcttt gatgcaggtt tcggagcctc ttatctggct
    14521 cgtgtcgt
//
