LOCUS       c00066_gnlPro..        14378 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BHGFKIHL_66.
ACCESSION   c00066_gnlPro..
VERSION     c00066_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 12:03:32
            Original ID  :: gnl|Prokka|BHGFKIHL_66
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14378
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..99
                     /locus_tag="ctg66_1"
                     /transl_table=11
                     /translation="TPVTRNREVSKALKAYASMVSSADKGAVRLID"
     protocluster    1..14378
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[190:4378]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      191..4378
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14378
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14378
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             191..1942
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.1e-47, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAKRPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             1936..2535
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_3"
                     /sec_met_domain="ALS_ss_C (E-value: 1.8e-19, bitscore:
                     60.6, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKSCEIKEFTLSMDKKLYTIIVHSENFAGLLNQVTAVFTRRQIN
                     IESLNVSASSIKGVHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIAL
                     YKITTPTLEEKPEVSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQ
                     FVRSGRVAITTSCFERVNEYLADREAKYRQSKHQES"
     CDS             2535..3284
                     /locus_tag="ctg66_4"
                     /transl_table=11
                     /translation="MSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEGK
                     KIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAALV
                     AKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDDA
                     GEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             3335..4378
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_5"
                     /sec_met_domain="IlvN (E-value: 9.6e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 8.6e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIIMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(4440..6272)
                     /locus_tag="ctg66_6"
                     /transl_table=11
                     /translation="MEYEYEKEEFKRQTENMGVARKVKRGLCWYPATPGRSYYNSLNQL
                     VIEITHTENTDIEHNFEFGRPVCFFRQSADGKITYMNFTATVSYADETRMVAIMPGAGA
                     VMEVQETDNLGVQLYFDETSYRTMFEALEDTLRSKGNRLAELRDILLGTSKAGFRELYP
                     VRFPWLNSTQETAVNKVLCARDVAIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSN
                     TAVDWISEKLVDRGVNVLRIGNPTRVNDKMLSFTYERRFENHPLYPELWSIRKNLRELG
                     SRARRGSYDEREGVRSRMSRLRDRATALEIQINAELFDGAHVIASTLVSSNHRLLNGRR
                     FGTLFIDEAAQALEAACWIAIRKADRVVLAGDHCQLPPTIKCYEAARGGLERTLMEKVV
                     SNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGELEAAPEVRYRGILDWDTPIHWIDTSEM
                     DFKEEFVGETFGRINKAEADLLLSELKIYINRIGGNRILEEKIDIGIISPYKAQVQYLR
                     SKIKADASLKPYRSLFTVNTVDGFQGQERDVIFISLVRANEEGQIGFLNDLRRMNVAIT
                     RARMKLVILGEAETLKHHGFYRKLLEFIQNIGNQ"
     CDS             6468..8711
                     /locus_tag="ctg66_7"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLRRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDVATATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKKPRLIGVHLKGKLSGWVAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPYDERMGTYLKATGRE
                     EVAEMAASVAADLRADDEVLANPEKYYDRIIEIDLSLLEPYINGPFTPDAATPISKFAE
                     VVITNNYPRRMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLKVASSLIVNPGSEQIRA
                     TAERDGMIAAFEDIGATIMANACGPCIGQWKRHTDDPERKNSIVTSFNRNFAKRADGNP
                     NTFAYVASPEITMALTIAGDLCFDPLRDTLVNAKGEVVKLSEPVGEELPAHGFIGGKEG
                     YIAPGKGQTEITVNPHSQRLQLLTPFPAWDGMDLLDMPLLIKVQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNKVWNRSTNTYGTVSGTAKLYKSEGIPSMVVAEE
                     NYGEGSSREHAAMEPRFLNVRVILAKSFARIHETNLKKQGMLALTFTDKADYDKIRERD
                     LISVMGLKDFAPGRTLKVVLHHEDGSKESFEVQHTYNEQQIAWFRAGSALNAR"
     CDS             8715..9698
                     /locus_tag="ctg66_8"
                     /transl_table=11
                     /translation="MEKITVPFITGDGVGAEVTPSMQAVVNAAVKKSYGDRRGIEWKEV
                     LAGERAFHETGSWLPDETMEAFRTYKVGIKGPLTTPVGGGIRSLNVALRQTLDLYVCQR
                     PVRWYKGIVSPLKEPQKVDMCVFRENTEDIYAGIEWEAGTPEAEKFYRFLRDDMGVTKV
                     RFPETSSFGVKPVSREGTERLVRAACRYALEHHLPSVTLVHKGNIMKFTEGGFKKWGYE
                     LAEREFGKELAEGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVSDQLAAMVGG
                     IGIAPGANINYKTGHXXXXXSRDGSEHCRERHCESLFHHPFRCDDA"
     CDS             complement(9583..10461)
                     /locus_tag="ctg66_9"
                     /transl_table=11
                     /translation="MGGMAKHVIGIRNDGREFRNKLNALPHQIIAGSVIGIRVETVHLE
                     HAARQDVHNVVSFKFNDIHLGLLLQRHVVVDEFTERREFFLVGQATGKQQVGNFLKTET
                     LLFDDGVCQVIHIITAVEQFAGNRLQPSTGDAFIADHIAYFGQPHQDSRAVLITQTALH
                     IKLPKQFILNPGSFLQIFGKLVNQILLLHNRFVLFVIPIFYSPYNLPGESRSGQRDATR
                     HKTGQVGSSTGFCETFLQGVLYKRGCFLPAQIFKHHHSGKDDGTGIHNVFPGNVRSRPV
                     XXXXXXAPFYS"
     CDS             complement(10468..10743)
                     /locus_tag="ctg66_10"
                     /transl_table=11
                     /translation="MVEHIGNLNIGTSMKRPFQGTDTCRYRRVSIRPGRRSDTYGKSGV
                     VTTTVLGLKNQQQVECAGIQLRVVLLQHIEEILGNGKVFLRMADMQ"
     CDS             10804..11229
                     /locus_tag="ctg66_11"
                     /transl_table=11
                     /translation="MLNKEVYNKTGLIYGIGHAVYTISDPRAILLKELARDLAREKGKE
                     REFAFLELLEERAIDVFGRVKNNGKTVSSNVDFYSGFVYEMIGLPQEIFTPLFAMARIV
                     GWCAHRNEELNFEGKRIIRPAYKNVLDEVTYVPIKKR"
     CDS             complement(11357..11965)
                     /locus_tag="ctg66_12"
                     /transl_table=11
                     /translation="MQIDEHTRKKQNDSQQGMRFQQIGPAIGIQAFGSKIEQTARLHHP
                     VQKVEDDTHRHNSYRHPAFTFQQERKNKGPLKIVQLKQQEKEIYRHGKSRSTLPPQPKH
                     DDEYRRFHKHPRQFIIDGDSPRGSTEHAITRFDKIERNKDNQCHSTHYPQKYLKSFLIH
                     SSLFMRSKDKENSQQTNRFPRIIVFSCKKQCFFTEKIKQ"
     CDS             11975..12247
                     /locus_tag="ctg66_13"
                     /transl_table=11
                     /translation="VIRHLRRPGDTKHYLPGKGLYRYVTSANYFGELVEWTGFAILTAS
                     PAAWVFVWWTFANLVPRADAIHRRYREEFGDEAVGKRKRIIPFLY"
     CDS             complement(12318..13412)
                     /locus_tag="ctg66_14"
                     /transl_table=11
                     /translation="MPAVATCILFGTHAVDEPRLIEQSARHLHSLEAVIQHLIYLVPGN
                     QATHINQRYLQGGTEFQGIFQEISFLKRYARYHPFAYHAYTVFQPPAGHVMRHAADRHF
                     APHDIHRRLTDEPTAQDQRMCSRLLQPPGHLHRLVQLHPSTETVAHVHLHQHSHITAGS
                     LHHFFHHHIHKTHTVLQRTSELVFPMVGGRGQELADEIAMPCMNLYRIKSGLPCQIHRT
                     PISTRHLWQLIGTQSAHKGRRVKIETGRCADGHTTANALMGHVATVSQLDACRSPFRMY
                     GISQPTESGDNLGTHPQLAVKRQAALSNCRIGNSSHTYTARRYRPMIVEQHVRRSVSGT
                     HALESSRTDGTVTQGQRSESDGCE"
     CDS             complement(13761..13991)
                     /locus_tag="ctg66_15"
                     /transl_table=11
                     /translation="MTDGIRTRYHIHNTAPLSHQWQQLASQQVRPYIIDTHRPFQSVLG
                     NAAFRFHGSGIVHQQRQRLSPLQQMLCKCDH"
     CDS             complement(13988..14176)
                     /locus_tag="ctg66_16"
                     /transl_table=11
                     /translation="MHGNDIGRHNPRVGRIHNNTFVLDTTGQVDGEQSQCQLRVAIYRN
                     APKATLLPRRKKSGKSR"
ORIGIN
        1 actccggtaa cccgcaaccg tgaagtctcc aaagcattga aagcatatgc cagtatggtg
       61 agttccgctg acaaaggggc tgtgaggctg attgattaaa agcccccctt tccgaaagcg
      121 aggggaggag agaatgaaac aaatttttca agctactatt gagcttttaa atataatgaa
      181 tagataaagt atggctgata ataataaaaa gagtaacttt tcctccctct cccaaggaga
      241 gggtcggggt gaggctctaa taacaggcgc agaagcattg atgcgctctc tggagcatca
      301 gggagtaaag actattttcg gttatccggg agggagcatc atgccggtat tcgatgcctt
      361 atacgaccat cggaaggaat tgaaccacat cttggttcgt catgaacaag gagcaaccca
      421 tgcggcacaa ggctttgcac gtgtatcagg cgaggttggc gtttgtctgg ttaccagtgg
      481 accgggtgct accaatacta tcacgggcat tgcagatgcc atgattgaca gtacgcctat
      541 cgttgtcatt gccggccagg tagggacgaa cttcttgggt acggatgcat ttcaggaagt
      601 ggacttggta ggcattactc agcctatcac gaaatggagt taccagattc gtcgtgcaga
      661 agatgtggcc tgggcagtgg cacgtgcttt ctatgtggca aagagcggac gtccgggacc
      721 ggtcgtgctg gattttgcta aaaacgccca agtggagaaa acagaatatg cgcctactaa
      781 ggtggactat gtccgtagct atcttcccgt tcccgaaatg gagccggagg ccatacggaa
      841 ggctgctgaa ttaataaatg gtgcgaaacg gcctttggtg ctggttggac aaggcgtgga
      901 gctgggagaa gcccagcaag agcttcgtgc tttcattgag aaagccggaa tgcctgccgg
      961 atgcacttta ttgggacttt ccgcattacc tacgaaccat ccgttgaaca aaggaatgct
     1021 tggtatgcac ggtaacctgg ggcccaatat caataccaat aaatgtgatg tccttatcgc
     1081 cgtaggcatg cgctttgatg accgtgtgac gggtaaattg gaaacatatg ccaagcaggc
     1141 gaagattatc cactttgata ttgaccctgc cgaaatagat aagaatgtaa agactgatgt
     1201 tgctgtcctg ggagattgca aagagacact ggctgccgtt acccaattgc tggaacccgc
     1261 caaccatcag gaatggattg acagtttccg gcaatacgag gaagtggaag aggaaaaggt
     1321 aatccgtccg gaattacatc cggcaggaaa agcgctaagc atgggtgagg tggtgcgtgc
     1381 tgtgagtgag gctacccata acgaggcgat attggtgact gatgtcggcc agaatcagat
     1441 gatgtccgcc cgttatttca aatacagcaa ggaacgtagc attgttactt ccggtggcct
     1501 gggtactatg ggcttcggcc ttccggcagc tatcggtgcc acttttggac gtccggaccg
     1561 cacggtatgc gtattcatgg gagacggcgg cttgcagatg aacctgcagg aactgggtac
     1621 catcatggaa caaaaggctc cggtgaagat gattctgttg aacaataact tcttgggcaa
     1681 tgttcgtcaa tggcaggcga tgttcttcaa tcgtcgttat tcgtttactc cgatgatgaa
     1741 tccggattat atgaagattg cttcggcata tgatattcct gcacgcaggg taatgacccg
     1801 cgaggagctg gcaaaagcga ttgacgagat gatagcgact gacggaccgt tcctgctcga
     1861 agcttgtgtg gaggaagaag gaaatgtaat gccgatgaca cctccgggcg gttcggtcaa
     1921 tcagatgttg ttggaatgct gaagtcatgc gaaattaaag aatttactct atctatggat
     1981 aaaaaactat atacaatcat tgttcattcg gaaaactttg ccggtttgct gaatcaggtg
     2041 acggctgtgt ttacccgccg gcagataaac atcgagagtt tgaatgtatc ggcctcctcc
     2101 atcaaggggg tacataaata taccattacc gcttggacgg ataaggatac cattgaaaag
     2161 gtgaccaagc agattaccaa gaaaatagat gtgctgcaag cccattattt cacggatgat
     2221 gaaatctatc agcacgagat tgccctttat aaaataacga cccctacgct ggaagaaaaa
     2281 ccggaggtgt ccaaagtaat ccgtaagtac aatgcccgta ttgtggaggt gaatgctgta
     2341 tttgccattg ttgagaagaa tggcatgagt gaggaaataa ccaatcttta tgaggagttg
     2401 cgccagttgg attgcgtact tcagttcgtc cgttcgggtc gcgtagccat tacgaccagc
     2461 tgctttgagc gtgtcaatga atatctggcg gaccgtgaag caaaatatcg tcaaagtaaa
     2521 caccaggaat catgatgagc gagaacaata aaataggtac ctacaagttt gttgccgaac
     2581 cgtttcatgt cgactttacc ggacggctga caatgggagt attgggcaac catttgttga
     2641 attgtgcggg tttccatgcc agcgaccgcg gttttggcat cgcgactcta aacgaggaca
     2701 attatacttg ggtattgtcc cgtctggctg tcgaactgga tgaaatgcct tatcagtacg
     2761 aagatttctc cattcagact tgggtggaga atgtctatcg cctttttaca gaccgtaatt
     2821 tcgctatcat cgataaggag ggtaagaaga ttgggtatgc acgttccgtt tgggcgatga
     2881 ttagcatgaa tacccgtaag ccggcagatt tgctggctct tcatagtggc agcattgtag
     2941 attatgtttg cgatgagcct tgcccgatag aaaaaccttc gcggataaag gtggcctcaa
     3001 aggaaccggt tgctgctttg gtagccaaat acagtgatat tgacattaac gggcatgtga
     3061 acagcatccg ttacatcgag catatccttg atttgttccc gatagagatg tataaggaga
     3121 agcgcatccg tcgttttgaa atggcatatg tagccgaaag ctattatggg gatgagttga
     3181 ctttgttcat ggatgatgcc ggtgagggcg tttacgatgt ggaggtgaaa aagaatggca
     3241 gcgaagtggt ctgtcgctct aaagtgatat ttacagagaa ataaataaat ttatcaacgt
     3301 tggcgtaagc cacaaataaa aattaaaaca aaaaatggca caattgaatt ttggcggtgt
     3361 tattgagaat gtaatgaccc gcgaagaatt tcctttggaa aaagcacgtg agattttgaa
     3421 agatgaaaca attgcagtaa tcggttatgg cgtacaaggc ccgggccagg cttgcaactt
     3481 gcgtgataac ggtttcaatg tgattgtagg acaacgtccg ggtaagacat acgaaaaggc
     3541 tgtggctgac ggatgggtac cgggtgagac tttgttcggc atcgaagagg cttgtcagaa
     3601 aggtactatc atcatgtgtc tgttgtctga cgcagctgta atgtctgtat ggccgactat
     3661 caaaccttat ttgactcccg gaaaggctct ttacttctct catggttttg ctattacctg
     3721 gaacgaccgt accggcgtgg ttcctcctaa agatattgat gttattatgg ttgctcccaa
     3781 aggttccggt acttcacttc gtaccatgtt cctcgagggt cgtggcttga actcatcata
     3841 tgccgtctat caggatgcta cgggtaaggc ttttgacaag acgattgcac tgggtatcgg
     3901 catcggttcg ggatatttgt tcgagacaac tttcatccgc gaagccactt ccgacttgac
     3961 cggtgaacgc ggttcattga tgggtgctat ccagggattg ctgttggctc agtatgaagt
     4021 attgcgcgaa aacggccata ctccttctga agcattcaat gaaacagtgg aagagttgac
     4081 tcaatctttg atgccattgt ttgccaagaa cggtatggac tggatgtatg ccaactgttc
     4141 tactacggca cagcgtggtg cgctggattg gatgaccccg ttccatgatg ccatcaagcc
     4201 ggttgtacag aaattgtatg caagtgtgaa gtcgggcaac gaagctcaga tttctatcga
     4261 cagtaactcc aaacccgatt atcgtgagaa gctgaatgca gaattgaaag ccttgcgtga
     4321 aagcgaaatg tggcagacag ctgttacagt tcgtaaactt cgtccggaaa acaattaatc
     4381 agctttatat aaataggtga aataccctct tcggtgttac cggagggggt atttctttat
     4441 tattgattcc ctatattttg aataaactcc aatagcttcc ggtaaaaacc gtgatgtttc
     4501 agcgtctctg cctctcccaa tatcaccagc ttcatacgtg cccgggtgat ggctacattc
     4561 attctcctta aatcattcag gaatcctatc tgtccttctt cgttggcacg gacaaggctg
     4621 atgaagataa catcgcgctc ttgcccttgg aagccatcca ccgtatttac agtgaacaag
     4681 ctgcgataag gcttgagtga agcgtctgcc tttatcttgc tgcggagata ttgcacttgt
     4741 gccttgtaag gggagatgat gccgatgtct attttttctt ccagaatgcg gttgccaccg
     4801 atacggttga tgtagatttt cagttctgat aggagcaggt ccgcttccgc cttattaatg
     4861 cgtccgaaag tctctcccac aaattcttct ttgaaatcca tttcggaggt gtcaatccag
     4921 tggatggggg tatcccagtc caggatgccc cggtaacgca cttcgggagc ggcttccaac
     4981 tcgccattat aaaaccattg ggaaggaaat ttcatgattt cctcgtgcat gcggtattgt
     5041 actttcagca aagagacaac ggcaggtttg ttggacacca ctttctccat caatgttcgt
     5101 tccagacctc cacgggcagc ttcgtagcat tttatagtgg gcggaagttg gcagtggtca
     5161 cccgccaaca ccacgcggtc tgcttttcgg atagctatcc agcaggcagc ttctaaggcc
     5221 tgggctgctt catcaatgaa aagggtgccg aaacggcgtc cgttcagcag ccggtgattg
     5281 ctgcttacta gcgtggaggc tatgacatgt gccccatcaa aaagctctgc attgatttgt
     5341 atttccaatg cggtggcgcg gtcgcgcagg cggctcatac ggctgcgtac tccttcgcgt
     5401 tcgtcatagc tgccacggcg ggcacggctg cccagttcac ggagattttt ccggatgctc
     5461 cacagctccg gataaagcgg atggttctcg aaacgacgct cgtaggtaaa ggaaagcatc
     5521 ttgtcgttga cacgggtcgg attgccgata cgcaggacat tgacgccacg gtccacaagt
     5581 ttttccgaaa tccagtcgac ggcagtattg ctttgggcac ataccagtac ctgcggttcc
     5641 cgatgcaggg tttcgtagat ggcttccact aaggtggtcg tttttccggt tcccggagga
     5701 ccgtgtacaa tggccacgtc gcgggcacac agcactttgt ttacagctgt ctcctgcgtg
     5761 gagttcagcc agggaaaccg tacgggatag agctctcgga aaccggcttt cgaggttccc
     5821 agcaatatgt cccgcaattc ggccaggcgg ttgcctttgg agcgtaacgt atcttccaag
     5881 gcttcgaaca tggtccgata ggatgtttcg tcgaaataaa gttgcacgcc gaggttgtcc
     5941 gtttcctgca cttccataac ggcaccggct ccgggcatta tcgctaccat ccgtgtctcg
     6001 tcggcatagc ttacggtagc ggtgaagttc atataggtta tttttccatc agcagactgg
     6061 cggaaaaaac atacgggacg gccgaactca aaattatgtt ctatatcggt attttctgtg
     6121 tgtgtaattt ctattactaa ttgattcagt gaattatagt aacttcgtcc cggagtggca
     6181 ggataccagc aaagtccccg tttcactttc cgggcaactc ccatgttttc ggtttggcgt
     6241 ttgaattcct ctttttcgta ttcgtattcc atgcgcagca aaacttgttg ctgctggagg
     6301 tgaataatag gactatttga atcttgttcc ttcatggttg caaaggtaat cattcttcgc
     6361 ttccgacgga aaaaatgctt tattttgtta aactattcag cctttttatt tgtttatgat
     6421 attaatttgt aatctttaca ataatgaaaa actaaaaaat agtggttatg gtatatgatt
     6481 taacgatgct caaaacgttt tatgctgctt attcggagaa gatagaacgc gtacggaacg
     6541 tactgcggcg tccgatgact ttagcggaga aaattttgta tgctcatttg tatgatgggg
     6601 ataaagtgaa gaactacaga cggggagaag actatgtgaa tttccgtccc gaccgtgtgg
     6661 ccatgcagga tgcaacggct caaatggcct tattgcaatt tatgaatgca ggccgtgagc
     6721 aggttgccgt gccttccact gtgcattgtg accatttgat tcaagcatat aaaggtgcaa
     6781 aagaagatgt tgcgactgct acgaagacca acgaggaggt ctataatttt ctccgtgatg
     6841 tttcttcccg ctatggcata ggtttttggc agccgggagc aggtattatt caccaggtgg
     6901 tattggagaa ctacgcattt ccgggtggaa tgatggtagg cacggactct catacgccca
     6961 atgccggagg tttgggcatg gtggccattg gtgtgggtgg tgccgatgcg gtggatgtga
     7021 tgaccggcat ggaatgggaa ctgaaaaagc cgcgtctgat aggcgtacac ttgaagggta
     7081 aattgagtgg ctgggtagct cccaaagacg ttattctgaa gttggcgggt attcttactg
     7141 taaaaggggg aaccaatgcc atcattgaat attttggacc gggaaccgct tcattgtctg
     7201 ccactggaaa ggctaccatc tgcaatatgg gggcagaggt gggggcgact acctcccttt
     7261 tcccttacga tgagcgtatg ggtacctact tgaaagctac cggacgtgaa gaagtggcgg
     7321 aaatggctgc ttccgtagct gccgaccttc gcgccgacga cgaagtgctg gcaaatccgg
     7381 aaaaatatta cgaccgcatc attgaaatag acctctcgtt attggaaccg tatatcaacg
     7441 ggccctttac gccggatgca gcaacaccga tatcgaaatt tgccgaggta gtgataacca
     7501 ataactatcc ccgccggatg gaagtcggtc tgatagggtc gtgcaccaat tcgtcctatc
     7561 aggatttgag ccgcgcggcc tcccttgccc ggcaggtaaa ggaaaagaat ttgaaggttg
     7621 cttcctcgct gattgtcaac cccggctcgg agcagatacg tgccactgct gaacgcgacg
     7681 gcatgattgc cgctttcgaa gatattggcg caacgataat ggcgaatgcc tgcggacctt
     7741 gtattggcca gtggaagcgc catactgatg accccgaacg caaaaattcc atcgtcacct
     7801 cttttaaccg taattttgcc aaacgtgccg atggaaatcc caacactttt gcttacgtcg
     7861 cttccccgga gataacgatg gcgctgacca ttgccggtga cctttgtttc gacccgttga
     7921 gggatacgct ggtcaatgcc aaaggagagg ttgtgaaact gtccgaaccg gtcggtgaag
     7981 aattgccggc acacgggttt ataggaggaa aggaaggata cattgctcca ggcaaaggac
     8041 agacggaaat tacggtcaat cctcattcac agcgcttgca actgctgact cccttccctg
     8101 cctgggatgg catggatttg ctggacatgc ctttattgat taaagtacag gggaaatgta
     8161 ccaccgacca catttccatg gcggggccat ggctccgttt ccggggacat ttggagaata
     8221 tttcggacaa tatgctgatg ggggctgtca atgctttcaa tggagagacg aacaaggttt
     8281 ggaaccgctc caccaatacc tatggaacag tgtcaggcac tgcgaagctg tataagtccg
     8341 aaggtatccc ttccatggtc gttgccgaag agaattatgg tgaaggttcc agccgtgagc
     8401 atgctgccat ggaaccgcgc ttcctgaatg tacgcgtcat tttggcgaag agttttgccc
     8461 gtatccatga gacgaactta aagaaacaag gcatgttggc gctgaccttt acggataagg
     8521 ccgattatga caagattcgg gaacgcgacc tgatttctgt catggggctg aaagattttg
     8581 ctccgggacg cacgttgaag gtggttcttc atcacgagga tgggagtaaa gaaagttttg
     8641 aagtacaaca tacgtataac gaacagcaga tagcttggtt ccgggccggt tctgcactta
     8701 atgcaagata gaatatggaa aaaattactg taccttttat taccggcgat ggagtgggag
     8761 cagaagtgac cccatccatg caggctgtcg tgaatgccgc tgtcaagaaa tcctatggcg
     8821 accggcgtgg cattgaatgg aaagaagtgc tggcaggaga acgtgctttc cacgaaaccg
     8881 gctcctggtt gccggacgaa accatggaag ccttccgcac ctataaggtg ggcatcaaag
     8941 gtcctttgac aactcccgtc ggcggaggta tccgttcctt gaacgtagcc ttgcgtcaga
     9001 cacttgattt gtatgtctgc caacgtccgg tacgttggta taagggcatt gtttctccac
     9061 tcaaagagcc gcagaaggtg gatatgtgcg tattccgtga gaataccgag gatatttatg
     9121 caggcatcga atgggaagcc ggaactccgg aggctgaaaa gttctatcgt tttctccgtg
     9181 atgacatggg ggtgacaaaa gtccgttttc ccgaaacctc ctcgtttggc gtgaagcccg
     9241 tttcaagaga aggaacagag cgcttggtgc gtgccgcctg ccgatacgcg cttgagcatc
     9301 atctgccttc cgtgaccttg gtacacaaag gaaacatcat gaaatttacg gaaggcggtt
     9361 ttaagaagtg ggggtacgaa ctggcagaac gtgagtttgg taaagagctg gcagaagggc
     9421 gtctggtcat caaggactgc attgccgatg cattcttgca gaacacgttg cttatccccg
     9481 aagaatattc cgtgatcgcc acgttgaatc tgaacggtga ttatgtgtcc gaccaactgg
     9541 ctgccatggt aggcggcatc ggcattgcac cgggtgcgaa tatcaactat aaaacggggc
     9601 atnnnnnnnn nnnnnnctca cgggacggct ccgaacattg ccgggaaaga cattgtgaat
     9661 ccctgttcca tcatcctttc cgctgtgatg atgcttgaat atctgggctg gaaggaagca
     9721 gcctctctta tagagaacgc cttggaggaa agtttcacag aagcccgtgc tactgccgac
     9781 ttggcccgtt ttatgccggg tagcgtctcg ctgtccactt cgactttcac ccgggagatt
     9841 gtaaggagaa tagaaaatgg gaataacgaa taaaacgaaa cgattatgaa gaaggagtat
     9901 ctgatttaca agctttccga agatttgaag gaagctaccc ggattgagaa tgaactgttt
     9961 aggaagtttg atgtgaagcg cggtttgcgt aatgaggacg gcacgggagt cttggtgggg
    10021 ttgaccaaaa taggcaatgt ggtcggctat gaacgcatcc ccggtggagg gctgaagcct
    10081 attcccggca aattgttcta ccgcggttat gatgtggatg acttggcaca cgccatcatc
    10141 aaagagaagc gtttcggttt tgaggaaatt gcctacttgt tgctttccgg tcgcctgccc
    10201 gacaaggaag aactctcttc tttccgtgaa ctcatcaacg acaacatgcc gctggagcag
    10261 aagaccaaga tgaatatcat tgaacttgaa ggaaacaaca ttatgaacat cctggcgcgc
    10321 agcgtgctcg agatgtaccg tttcgacccg gatgccgatg acacttcccg cgataatctg
    10381 atgcggcaga gcattgagct tatttcgaaa ttcccgacca tcattgcgta tgcctataac
    10441 atgcttcgcc atgccaccca tggccgttca ctgcatatcc gccatccgca ggaaaacctt
    10501 tccattgccg agaatttcct ctatatgctg aagaaggact acacggagct ggatgcccgc
    10561 acactcgacc tgctgttggt tcttcaggcc gagcacggtg gtggtaacaa ctccactttt
    10621 accgtacgtg tcacttcttc taccgggacg gatacttact cttcgatagc ggcaggtatc
    10681 ggttccttga aagggccgct tcatggaggt gccaatattc aggttgccga tatgttccac
    10741 catctgcagg aaaacattca ggactggacg aacgtggatg agattgatac ttacttcacc
    10801 cgcatgctca acaaggaagt ctataacaag accggtttga tatatggtat cggacatgcc
    10861 gtctatacca tttccgaccc gcgcgccatt ctgctgaagg agcttgcccg cgaccttgcc
    10921 cgcgaaaaag ggaaagaacg tgagttcgct ttccttgaac tgctcgagga gcgcgccatt
    10981 gatgtgtttg gccgtgtgaa gaataatgga aagacggttt cgagcaatgt ggatttctat
    11041 tcgggctttg tctacgagat gattggactg ccgcaggaaa tcttcacgcc tttgtttgct
    11101 atggcacgta ttgtcggttg gtgtgcacat cgcaatgaag aattgaactt tgaaggtaag
    11161 cgtattatcc gtcctgccta taagaatgtt ttggatgagg tgacttatgt gcccattaag
    11221 aaacggtaag gattagactt gtatctttta aatcgttcca tcacggggga aaaatcgttc
    11281 caccatggtg gaacgatttt ttctccatgg tggaatgaaa tttactccat gatggaacga
    11341 ttagattttt gtatctctac tgcttaatct tctcagtaaa aaaacactgt tttttgcatg
    11401 aaaaaacaat tatccgggga aaacgatttg tttgttgtga gttttcttta tctttgcttc
    11461 gcataaataa agaactatga atcaggaaac ttttcagata tttctgtggg taatgagtgc
    11521 tgtggcattg gttgtcttta ttgcgctcta ttttgtcaaa gcgggttatg gcatgttccg
    11581 tactgcctcg tggggaatct ccatcaataa taaactggcg tgggtgctta tggaagcgcc
    11641 ggtattcatc gtcatgtttg ggttgtgggg gaagagtgga gcgggatttg ccgtgccggt
    11701 atatttcttt ttcctgctgt ttcagttgca ctatcttcag cgggccttta tttttccgtt
    11761 cctgctgaaa ggtaaaagcc ggatgccggt agctattatg gcgatgggta tcgtcttcaa
    11821 ccttttgaac gggatgatgc aggcgggcgg tttgttctat tttgctcccg aaggcttgta
    11881 tgccgatggc tgggcctatt tgctgaaacc tcatgccttg ttgggaatca ttctgttttt
    11941 tgcgggtatg ttcgtcaatt tgcattccga ctatgtgata cgtcatctgc gcaggccggg
    12001 tgatacgaag cattatcttc ccggaaaagg gctttaccga tacgtcactt ctgccaatta
    12061 cttcggtgag ctggtggaat ggacggggtt tgccatactc acagcttctc ccgccgcctg
    12121 ggtgttcgtc tggtggacgt ttgccaacct tgttccccgt gccgatgcca ttcaccgccg
    12181 ttatcgggag gagtttggtg atgaggcggt aggaaagcgc aaacgcatca ttccatttct
    12241 ttattaatgg aaaatggaga gttgaaaatg gaaaatgaat aattcataac ttataactca
    12301 taacgatgga atccaagtta ttcacacccg tcactttcgg accgttgacc ttgcgtaacc
    12361 gtaccatccg ttcggctgct ttcgagagca tgtgtcccgg aaacgctccg tcggacatgt
    12421 tgctcgacta tcatcggtcg gtagcggcgg gcggtatagg tatgactact gttgcctatg
    12481 cggcagttac tcagagcggc ctgtcttttg accgccagtt gtggatgcgt cccgagatta
    12541 tccccggact ccgtaggctg actgatgcca tacatgcgga aggggctgcg gcaggcatcc
    12601 agttgggaca ctgtggcaac atgtcccata agagcatttg cggttgtatg cccgtcggcg
    12661 catcttccgg tttcaatctt tactctccta cctttgtgcg cggactgcgt gccgatgagc
    12721 tgccagagat ggcgcgtgct tatgggcgtt cggtgaatct ggcacgggag gccggatttg
    12781 attctgtaga gattcatgca gggcatggct atctcatcag ccagttcttg tccccgtcca
    12841 ccaaccatcg gaaagacgag ttcggaggtt cgttgcagaa ccgtatgcgt tttatggata
    12901 tggtgatgga agaagtgatg aaggctgccg gcagtgatat ggctgtgctg gtgaagatga
    12961 acatgcgcga cggtttccgt ggagggatgg agctggacga gacgatgcag gtggcccgga
    13021 ggctggagca gtcgggagca catgcgctgg tcttgagcgg tgggttcgtc agtaaggcgc
    13081 cgatgtatgt catgcggggc gaaatgccta tccgcagcat gacgcattac atgacctgct
    13141 ggtggttgaa atacggtgta cgcatggtag gcaaatggat gataccgagc gtaccgttta
    13201 aggaagctta tttcctggaa gatgccttga aattccgtgc cgccttgaag ataccgttgg
    13261 tttatgtggg tggcctggtt tccagggaca agatagatga ggtgctggat gacggcttcg
    13321 aggctgtgca aatggcgcgc gctctgctca atgagccggg gttcgtcaac cgcatgcgtg
    13381 ccgaagagaa tgcacgttgc aactgccggc atagtaatta ttgcattgcc cggatgtatt
    13441 ccatcgagat ggcatgccat cagcatttga aggaggaact tccaccttgt ctgaaaaagg
    13501 agatagagaa aatcgaagcg aaaggctgat ttttagtttt taattttcaa tttttaatta
    13561 ttaaagtgaa tttagctgtt ataactgggg cagacggtgg catgggcatg gaaattaccc
    13621 gcgcagtggc aactgccggc tatcaggtca tcatggcatg ccgtgacccc caagctgccg
    13681 aacccaagcg gcaactgctg atgcgtgaaa ccggtaatcc gcgtattgag actgctccca
    13741 ttgatttggc atctctggct tcagtggtcg catttgcaga gcatctgttg aagcggggag
    13801 agccgttggc gttgttgatg aacaatgccg gaaccatgga aacggaacgc cgcattaccg
    13861 aggacggact ggaacggacg gtgagtgtca attatgtagg gccttacctg ctgactcgca
    13921 agctgctgcc attgatggga gaggggagcc gtattgtgaa tatggtatct tgtacgtatg
    13981 ccatcggtca tcttgacttt ccggattttt tcctccgggg aagaagggtg gcttttggcg
    14041 cattcctata tatagcaaca cgaagctggc attgactctg ttcaccatcg acttggccag
    14101 tcgtgtcaag cacaaaggta ttgttgtgaa tgcggccgac ccggggattg tgtctaccaa
    14161 tatcattacc atgcatatgt ggtttgaccc gctgacagat atacttttca ggcctttcat
    14221 ccgtactccc cgtaagggag ctgcaacagc tgtcggctta ttgctggatg aggatgccgg
    14281 taaacgtacg gggacattga atgccagttg ccgtcccaag tctctttcgg agaagtacac
    14341 ccggcatgta cagatggaag aactgtggga gaggacgg
//
