LOCUS       c00074_gnlPro..        14584 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DNDNJIKL_74.
ACCESSION   c00074_gnlPro..
VERSION     c00074_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 12:15:13
            Original ID  :: gnl|Prokka|DNDNJIKL_74
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14584
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14584
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[56:4584]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      57..4584
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14584
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14584
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(57..1217)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg74_1"
                     /sec_met_domain="OAD_beta (E-value: 1.3e-153, bitscore:
                     501.2, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLTFLGENLQLFLTYTGVYNATPGHLIMILVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQVGIYEQGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYTIALQMGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRLLTTKKERLIRMKPPRAVSSTEKIIFP
                     IVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDTITILLGITVGAS
                     TQATQFLTLNSIKIFGLGALSFVIATCAGVLFVKLFNLILKDGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLG"
     CDS             complement(1222..1653)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.8; E-value:
                     1.6e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg74_2"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.3e-21, bitscore:
                     64.8, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNVYKVHINSVVDDIADVEVNGTPYQVKLEKPAKKQ
                     MVTLKRPAQAPTTASGDPVVTRPAASTTQGAVKTPLPGVILQVKCNVGDTVKRGQTLII
                     LEAMKMENNINADRDGKIIEIKVHKGDSVLEGADLVVIG"
     CDS             complement(1675..2562)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg74_3"
                     /sec_met_domain="OAD_gamma (E-value: 4e-13, bitscore: 40.1,
                     seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKKIGVLLLFALLISFGAKAQRATSMRINEVLVINEDNFVDDY
                     GKRHGWIELFNTSAGTVNIAGCYLTDDKNNPMKYPIPKGDVLTQIQPRQHTLFWADGQP
                     GRGTFHVNFVLDPSKENYIALYDADGKTLIDEVTIPAGQMADISYGRVIDGKDEWAQLK
                     KVTPSTNNLTLDSNEKIDNFKQNDSLGIGMTITAMAVVFLGLFLLYIIFKQIGRLSISA
                     SKRNAQKAAGTTSVSVDAGQESGEIFAAIATALYEMSDDNHDIEHTVLTIHKVQRTYSP
                     WSSKLYGLRQTPHK"
     CDS             complement(2584..4137)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg74_4"
                     /sec_met_domain="CT_Btheta (E-value: 1.4e-292, bitscore:
                     960.5, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     EALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEDGLQLIRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             complement(4174..4584)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg74_5"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.8e-27, bitscore:
                     85.0, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTHIEHLGIAVKSIEACLPYYEGVLGLKCYNIEVVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALNEAEEKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGNK"
     CDS             complement(4713..7124)
                     /locus_tag="ctg74_6"
                     /transl_table=11
                     /translation="MKIRAIAALLFILISVSAFGEGRIKITGYVRDADGNPLELVNVRV
                     KNTLIGSMTNEKGYYSFSISPGDSISIIYSCLGYNKAERIIPSAQADMRLNVQMNYTSF
                     DLGEVSVTAIRKQTTTMESLNADKIKLLPDPSGGSIESLVVTFAGVSSNNELSSQYSVR
                     GGSYDENIVYVNGIEVFRPLLIRSGQQEGLSFINPDLTEAVNFAAGGFEARYGDKMSSV
                     LDITYKKPKIFEGSASASLLGANAYVGSSIGKFTQVTGFRFKSGRSILGTMDTDAEYDP
                     KFIDLQTYITYQLAPKWEINFLGNLANNNYKFTPYSRETSFGTAEHPKNFKVYFDGRER
                     DRFQTLFGALTLKHNPNENTELGLQASAFKSKEEEGYDIAGEYWLSENGAENPNDDASA
                     AMSVGRYHEHARNRLNSTVMNVGHYGMARLLNNTLKWGATVQMEKINDKISEWEKRDSS
                     GYSLPQTGNNVSVYSNLFSDNQIESTRFSAYAQDAFKFRTKQGLFTLVAGVRGSYWTYN
                     KEFLFSPRASLGFIPNFDQDLTLRFATGLYYQSPFYKELRRVDKDKNGNNITVLNKDLK
                     SQRSIHFILGGDYTFRAVDRNFKVTAEMYYKKLDNLNPYTVDNVKIRYYGENCAKGYAM
                     GLDVKFFGEFVPGTDSWISFSLMKAQQTIRETTTVPMANSQGYNISLFFQDYFPGYKRV
                     KLNLKGVLSGGLPQTIPGKGYEAGYFRTPAYKRVDIGLSYQLAGGTDAIMDRGFFRHLK
                     NIWLGLDVFNILDIKNVSSYYWITDVYNVQYAVPNYLTGRQLNVRLIVDF"
     CDS             7246..7806
                     /locus_tag="ctg74_7"
                     /transl_table=11
                     /translation="MESFATLIQNRRSTRKFTEQLLSPEQVELILKAALMAPASKRSNP
                     WQFVVVEDKEMLKKLAGCKKNGSAFLEGCALAVVVLANVMESDVWIEDASVASIYMQLQ
                     AEDLGLGSCWCQIRNRVTEDEADSNNYVRSLLDIPYQLDVLSIIGIGYKDQVRKPFDES
                     HLQWEKIHIGKFSLPEENKEAEE"
     CDS             7803..8570
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg74_8"
                     /sec_met_domain="F420_oxidored (E-value: 1.2e-09, bitscore:
                     28.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVVFVGAGNLATRLSLEMRKSGMSIGQVYSHTSEHAKILADELG
                     CGWTVVPEDIVEDADLYVFSLKDAVLQDVIARVKPNNGLWVHTAGSMPISVFEGLTARY
                     GVVYALQTFSKSREVDFKKIPFFLEANSSEDEKVLGEVARALSSDVRFLSSEKRKNLHL
                     AAVFACNFTNHMYALAEKILEEQQIPGEVLLPLIDETAAKVHVMSPARAQTGPAIRYDE
                     NVINKHMAMLKDPDMRNLYELISRSIHKEARHE"
     CDS             8563..9084
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg74_9"
                     /sec_met_domain="HAD_2 (E-value: 5.8e-09, bitscore: 26.4,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSINYDLRKIKAFVFDVDGVLSCDVIPLHPNGDPMRTVNIKDGY
                     ALQLAVKKGYEVAIITGGYTEAVQIRFSRLGIQHIYMRSAVKVHDFKDFMEKTGLSPEQ
                     IMYAGDDIPDYEVMTRVGLPVAPADAAPEIKEIAKYISSRRGGEGVARDVIEQTMRAQG
                     HWFGEEAFGW"
     CDS             9122..9703
                     /locus_tag="ctg74_10"
                     /transl_table=11
                     /translation="MLENLKKYKIVLASNSPRRRNLLSGLDIDFEVRIIPDIDESYPDS
                     IDSMEIPLYIARSKAEAYKSTMADDELLITADTIVWTFDGVMGKPANREEAYAMLHALS
                     DHVHQVITGVCIMTKDKNVGFSVESAVCFAKLGDEEINYYLDKYKPYDKAGGYGIQEWI
                     GYIGVEAINGSFYNVMGLPVQKLYQELKHF"
     CDS             complement(9706..10083)
                     /locus_tag="ctg74_11"
                     /transl_table=11
                     /translation="MKRYLNQLECKILRAGDSLFNTTTTDNLLIFVFSGKLIIYSQEGT
                     HIAEVAKDHFMLLAQNTNHKVIASAPTRLILIHAGSLSDMIINDPEWNVEKPVVLPIPP
                     ALAHTLNQIEYYMKDKYFTLN"
     CDS             complement(10092..11120)
                     /locus_tag="ctg74_12"
                     /transl_table=11
                     /translation="MRKNITILVSLLILSHTACSDKGQYFEESGSVFHTSYHIKYKAKQ
                     ILTDKIDSELQRFNLSLNPFNPNSTIAKVNNNEDVEVDEWFTEVFNKAEEISQKSGGAF
                     DITCAPLINLWGFGFSKMDSVTPQMIDSIKAFVGYQKVRLEGKKIIKEDPRILLNCSSI
                     AKGYACDVIARLLEKEGVKNYMVEIGGEVTMKGVNQQGDCWRVGINKPEIGTSGVTNDV
                     EEIVQLCQKGGVATSGDYRNFYIKDGKKYAHTINPATGYPAGQNILSATIVAEDCMTAD
                     AYATTFMVLGVEKAKLLAQSIPQIEYFIIYADNNGQQKVTYSKGMLEYLPNRKTLAILE
                     NP"
     CDS             complement(11146..12870)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ILVD_EDD"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg74_13"
                     /sec_met_domain="ILVD_EDD (E-value: 5.9e-184, bitscore:
                     602.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSQQLRKLAPELDSLRLGSGWKIDELSKPQIIVESSYGHSHPGS
                     AHLDKLVDEAGIGIKEKGGRAANYFVTDICDGEAQGHDGMNYSLVSRDIMAAMMEIHVK
                     ATPFDAGVFIASCDKSVPAHLMAIARLDMPAIFMPGGIMKAGPNLLTLEQIGTYSAQYE
                     RKEITEEQFMVYKRDACPDCGACSFMGTASTMQVMAEALGIALPGSALIPAHLPELKET
                     ARKAGEHALGLAKEELKPSDIMTIQAFENAIMVHAAIAGSSNSLLHLPAIAHELGIQLS
                     PDLFDKIHRKIPYLLNIRPSGFWPGEYFWYAGGVPAIMEEIKEFLHLDVMTVTGKTLEE
                     NLKDLQLNGFYENCHKYLPALGVKVGDIIKPFHTPIKAQGAIAILKGNLAPEGAVVKHS
                     AISPRLMQVTLKARVFDCEENAIEAVLQKKIHPGEAVFIRYEGPKGSGMPEMFYTTEAI
                     ASDPELVETIALITDGRFSGATRGPAIGHVSPEASEGGPIALVENDDLIRIDIPARTLD
                     IIGTDSIERSVEEIEKILSERRAHWIKPESQYKKGILDIYTHNSVSPMKGAYMEFFM"
     CDS             complement(12915..13481)
                     /locus_tag="ctg74_14"
                     /transl_table=11
                     /translation="MLYIEVLLLAIGLSMDSLAVSVTGGAVLKNNCTAGNIIKIASVLG
                     IFQAGMTVIGYTMGLGFEKYICAFDHWIAFTLLLYLGGKMIYDSAKEEEEDGKFDPLCN
                     RTLCGLGIATSIDALAVGISLAILKSPLLLQASTIGVVTFAISAFGVYFGNRFGKRIDL
                     KLDLIGGLILIGIGTKILIEHVFFS"
     CDS             complement(13483..14004)
                     /locus_tag="ctg74_15"
                     /transl_table=11
                     /translation="MSFLELARKRCSIRKYAPKNVEQEKIDYILEAARLAPSAVNYQPW
                     YFVWVQSAEGKAKLQECYPREWFKQAPYYLIVCGDHQQSWKRGDHKDHMDIDTAIATEH
                     ICLAAAEQGLGTCWVCNFDTELCRKHFKIPETIEPVVLIPFGYPSDPALFDETPKKRKP
                     IEEIIKRESF"
ORIGIN
        1 ataaaaaggc gggatccttt cggacctcgc cttttttaat atagatagtt gttttattaa
       61 ccaaggaatc ctagcaagat accggcagct acagcggaac cgattacacc tgctacgttc
      121 ggacccatag cgtgcatcaa caagtagttg gtcgggtcat attccaaacc tacaacttgt
      181 gagatacgag ctgagtcagg aacggcggat acaccggcgt taccgataag cggattgatc
      241 ttattgccgt ctttcaatat taaattgaat aacttaacga acaatacacc ggcgcaagta
      301 gcgatcacga atgataacgc acctagaccg aagatcttga tagagttcaa tgtcaagaac
      361 tgtgtagctt gggtagaagc acctaccgtg atacccaata agatcgtgat tgtatcgatc
      421 agcggaccac gagcagtctc tgccaaacga cgagtcacgc cactttcttt caataagttt
      481 ccgaagaata gcatacctaa caatggtaaa ccggacggaa ccaagaagca agtaagcaac
      541 aaaccaacga tcgggaagat aattttttcc gtggaagaaa cggctctcgg cggtttcata
      601 cggatcaaac gctctttctt agtcgtaagc aatctcatga acggcggttg gataatagga
      661 accaacgcca tgtatgagta agcggatacc gcgatcgcac ccattaagtt tggcgctaac
      721 ttagaagaca ggaagatagc cgtcggaccg tcagcaccac cgataatacc gatagcacct
      781 gcttggttcg gctcaaatcc catttgaaga gcaatcgtat aagcaccaaa gataccgaac
      841 tgagccgctg caccgatcaa catcaactta ggattggaga tcaatgcgga gaagtcggtc
      901 atggccccga taccgaggaa gatcaatggc ggataccatc cagaagtcac accctgatag
      961 aggatgttca gtacagaccc ttgctcataa atacctacct gaagacctgc gtccttgaaa
     1021 gggatattac cgatcaagat accaaatccg atagggatca aaagcatcgg ttcaaactca
     1081 tatttaatcg ccaggaatat aaacaacaga cctaccagaa tcatgatgag atgtcccgga
     1141 gtagcgttgt atacacctgt ataggtaagg aacagttgta agttctcacc taagaatgtt
     1201 aaaaagctct cttgcatagt cttatccgat tactacgaga tcagcacctt ctagcacaga
     1261 gtctcccttg tgtactttaa tttctataat cttaccgtca cggtctgcgt tgatgttgtt
     1321 ctccatcttc atagcctcaa ggataatcaa tgtttgacct ctcttcacgg tatcacctac
     1381 gttgcactta acctgcaaga taacacctgg cagcggagtc ttaacagcac cttgtgtagt
     1441 agaggctgcc ggacgagtaa ctacagggtc gccacttgct gttgtcggtg cttgagccgg
     1501 acgtttcaat gtaaccattt gtttcttcgc cggtttctct aattttactt gataaggtgt
     1561 accatttact tcaacatctg cgatgtcatc cactacagaa ttgatgtgta ctttatatac
     1621 gttaccgtta atggtatatt taaaactttt cattctttgt tcgtttttag ataattactt
     1681 atgtggggtt tgacgcaaac cgtagagttt tgaactccaa ggagaataag tcctttgtac
     1741 cttgtggatc gtaagaaccg tgtgctcgat gtcatgattg tcatcactca tctcgtacaa
     1801 agcggtagcg atagcggcaa agatctcacc agactcttgt ccggcgtcaa ccgatacact
     1861 tgttgttccc gcagcttttt gagcgttacg tttgctcgcg gatatagaca atctaccgat
     1921 ctgcttaaag atgatgtata acaaaaataa tcccaagaac actacagcca tagcggtaat
     1981 ggtcataccg atacctaaag agtcattctg tttgaaatta tcgattttct cattagaatc
     2041 caatgttagg ttattcgtac tgggagtaac tttcttcagc tgtgcccatt catctttacc
     2101 atcgatcact ctaccgtaac tgatatcagc catttgtccg gcagggatcg taacttcgtc
     2161 gatcaatgtt ttaccatctg catcatacag agctatataa ttctccttag agggatctaa
     2221 tacgaagtta acgtggaatg tacctctgcc cggctgtccg tcagcccaaa atagtgtgtg
     2281 ctggcggggt tggatctgag tcaatacgtc tcccttcggg atcggatatt tcatcggatt
     2341 gtttttgtcg tctgtcaaat aacatcccgc gatatttacc gttccggccg aagtgttgaa
     2401 caactcaatc cagccatgac gtttgccata gtcgtcaacg aagttatcct cgttgataac
     2461 caatacttca ttaatacgca tggaggttgc gcgctgtgcc tttgccccga atgaaatgag
     2521 caaagcgaac agtagcaata cccctatttt cttatttatc atattcatct cctgttttac
     2581 ggattataga ggcaggttat catgtttctt agcaggattg cttaacttct tagtctgcaa
     2641 ttgctgcaaa gcacgaataa tacggaaacg agtgttacgc ggttcgataa catcgtcgat
     2701 ataaccgtat tgagctgcgt tataaggatt agcgaatgct ttcttatatt cagcttcttt
     2761 ctctgctgcg catgctttcg gatcttcagc ggctgctact tccttggcga agataacctc
     2821 tacggcaccg ctcgggccca taacggcgat ctcggctgtc ggccatgcgt aattcatatc
     2881 accacgtaaa tgtttagaac tcatcacgca ataagctcca ccgtaagact tacgcaatgt
     2941 aacggtaatc ttaggaacgg tagcctcacc ataagcgtaa agcaatttag cgccgtgaag
     3001 gattacaccg ttgtattcct gacctgtgcc cggaaggaat cccggaacgt caaccaatgt
     3061 taccaaagga atattgaaag cgtcgcagaa acgaacgaag cgacctgctt tacgagatgc
     3121 gttgctatcc aagcatcctg ccataacctt cggctggtta gctacgatac cgacggattg
     3181 tccgttgaaa cgagcgaaac ctacgatgat attcttagcg tagtccgcat ggacctctag
     3241 gaactcgttg ttatcgacga tcgtaccgat aacctcatac atatcgtaag attggttggc
     3301 gttatcggga atgatatcgt tcaatacatc atccagacga tcgatcgggt ctttgcactc
     3361 aactaacggc gtttcctcta agttgttctg aggtaagaaa ctgagcaatt tacgaatcaa
     3421 ttgcaaacca tcttcttctg tatcgacagc gaaatgggct acacccgatt tggtagtgtg
     3481 tacgctggct ccacccaact gctcttgggt tacatcctca cctgttacgg tttttacgac
     3541 tttcggacca gtcaagaaca tatagctggt accacgtgtc atgatgttga agtctgtcaa
     3601 agccggagaa taaacggctc caccggcgca agggccgaag ataccggaaa tctgaggaac
     3661 aacaccggaa gccaagatgt tacgttggaa aatctcagcg tatcctgcca aggcatttac
     3721 tccttcttgg atacgagctc caccggagtc gttcaaaccg ataacgggag cgcccatctt
     3781 catggcttga tccattactt tacagatctt catagccaaa gcctcagaca aggctccacc
     3841 gaatacggtg aaatcttgag cgaagatata taccaaacgt ccgtcgatcg taccataacc
     3901 tgttacgata ccatcgccta aatatttagt tttctcgata ccgaagtttg tacaacggtg
     3961 ttgaacaaac atgtcgaatt cctcgaaact accttcgtca agcaacatgg cgatacgctc
     4021 acgagcggta tatttgcctt ttttgtgctg tgattcgatt cttttctctc ctccacctaa
     4081 gcgagcttgc tcacgaagtg cgatgagctc ttttactttt tcaagctggt tactcattgt
     4141 attttgattt gttgttagaa atgaacggat taattatttg ttgcccggca tgcaaagctc
     4201 tgtcaatacg ctgcaagttg atttcgggtg aaggaaagcg atgttcaagc cttccgcgcc
     4261 accacgggga gctttatcga ttaatttaac gcctttttcc tcagcctcgt tcaaagctgc
     4321 ctgtacatca ggtaccgcga atgcgatatg gtggatacct tcaccttttt tctcgataaa
     4381 ttttgcgatc gtgctatctt cgctggtcgg ctctagtaat tcaatcttag tctgtcctac
     4441 cttgaaaaat gcggttttta ctttttggtc tgctactact tcgatattgt agcattttaa
     4501 tccaagaacg ccttcataat agggtaaaca agcctcgata ctcttcactg cgatacctaa
     4561 atgttcgata tgtgtaagtt ccatgtcaat aataatttaa agatttagta aatgtttgtt
     4621 tctattgtgt gcaaatgtac actacttttt atgaatgagg aaataatttt ttgtttttat
     4681 ctcccagtaa atgtgtttaa agatacattt tattaaaaat cgacaatcag acgaacgttc
     4741 aattgacgtc cggtcagata gtttggaact gcgtattgga cattatatac atctgttatc
     4801 caatagtagg aactaacgtt tttgatgtct aatatgttaa atacatccag acctagccaa
     4861 atgtttttca aatggcggaa gaagcccctg tccatgatag cgtccgtgcc tcctgccaat
     4921 tgataggaga ggccgatatc tacacgtttg taggcgggcg tacggaaata gccggcttcg
     4981 tatcctttgc ccgggattgt ctggggaagt cctccggata gaactccttt cagatttagc
     5041 ttgactcgtt tatagcccgg gaaataatct tggaagaaga gtgagatgtt gtagccttgg
     5101 ctattggcca taggaacggt cgttgtttcc cggatggttt gctgggcttt catcaaggag
     5161 aagctgatcc atgagtcggt acccggtacg aattctccga agaatttgac atcgagtccc
     5221 atggcgtaac ctttggcgca gttctcaccg taatagcgga tcttgacgtt atctacggtg
     5281 tagggattca gattgtccag ctttttatag tacatctcgg cggtcacctt gaaattccgg
     5341 tctacggcac ggaacgtata atctcctccc aatatgaaat ggatggagcg ttgtgacttt
     5401 agatctttgt tcaataccgt gatattattg ccgttcttat ctttgtctac tctacgtaat
     5461 tccttgtaga agggcgattg ataatacagt ccggtggcga aacggagcgt caagtcttgg
     5521 tcgaagttcg ggataaagcc caatgaggca cggggactga aaaggaactc cttattataa
     5581 gtccaataac tacctctaac ccctgcgact aacgtgaaca gaccttgctt ggtcctgaat
     5641 ttgaatgcgt cttgcgcata agcggaaaag cgtgtgcttt ctatctgatt atcagaaaag
     5701 aggttcgaat atacacttac gttattaccg gtttggggca aagaataacc tgaggaatcc
     5761 cttttttccc attcactgat cttatcattg attttctcca tttgtaccgt ggctccccat
     5821 ttcaacgtat tgtttaaaag gcgggccatc ccatagtgcc cgacattcat gacggtggag
     5881 ttcaaacggt ttcgtgcgtg ctcgtgataa cggcctacgg acatggcggc tgacgcgtcg
     5941 tcattcggat tttccgctcc gttctcgctc agccaatatt ctccggcgat atcgtatccc
     6001 tcttcttcct tgcttttgaa agcggaggct tgaagtccca actctgtgtt ctcattgggg
     6061 ttgtgtttca atgtaagcgc accgaataag gtttggaaac ggtctctttc ccttccgtcg
     6121 aaatagactt tgaagttctt gggatgctcg gctgtaccga aagaggtttc ccggctataa
     6181 ggggtgaatt tataattatt gttagcgagg tttcccaaga aattgatttc ccatttaggg
     6241 gccaattggt acgtgatgta agtttgcaga tcgataaatt tagggtcgta ttcagcgtct
     6301 gtatccatgg tacccaaaat agaccgaccg cttttaaagc ggaaacccgt tacttgggta
     6361 aatttaccaa tagaactgcc tacataagca ttcgcaccca acaagctcgc agaagctgag
     6421 ccttcgaata tcttaggctt tttataggta atatccagca cggaactcat cttgtctccg
     6481 taacgggcct cgaagccacc ggcggcgaaa ttgaccgcct ccgttaggtc cggattgata
     6541 aagctaaggc cctcttgttg tcccgagcga atcagaagtg gacggaatac ctcgatccca
     6601 ttcacataaa cgatattttc atcataacta cctccacgta cggaatactg ggaacttaac
     6661 tcgttattgg acgatactcc ggcaaacgta acgaccaagc tctctatact acctccggaa
     6721 ggatcgggca ataacttgat tttgtccgca tttagggact ccatggtcgt ggtctgcttg
     6781 cggatggcag taacagatac ttcccctaaa tcaaatgagg tatagttcat ctgtacgttc
     6841 aggcgcatat cggcttgtgc cgagggaatg atacgttcag ccttattata tcccagacaa
     6901 gagtaaataa tggagataga atcccccggc gatatggaaa aggaataata tcccttctcg
     6961 ttggtcatgg agccgatcaa cgtgttctta acccggacat tcactaattc cagagggtta
     7021 ccgtcggcgt cacggacata accagtgatt tttatgcggc cttcgccaaa ggcactcacg
     7081 gaaataagta taaatagcag cgcggctatc gcacgaatct tcataatcta ttgttcaatt
     7141 ataaaaatac taacgagaaa aaagaacgat acgtatatat gggtgcaaaa aattatattt
     7201 atatttgcga atcttaatat taaaagagta caaagaacga aaaaaatgga gagttttgca
     7261 acacttatac aaaatagaag aagtacacgt aagtttaccg aacaactact ttcacccgag
     7321 caggtagaac tgatcttgaa agcggcgttg atggctccgg cctcaaaacg tagtaatcct
     7381 tggcagttcg tggtcgtgga agataaggaa atgttgaaga aacttgccgg gtgtaagaaa
     7441 aatggttctg cttttctgga gggttgtgcc ttggccgtgg ttgtcttggc gaatgtgatg
     7501 gaaagcgatg tttggatcga ggacgcttcg gtcgcttcta tttatatgca attgcaggcg
     7561 gaggatttgg gattgggcag ttgctggtgt cagatccgga accgggtaac agaggacgag
     7621 gcggattcga ataattatgt tcgttcgttg ctggatatcc cttatcaatt ggatgtcttg
     7681 tctatcattg gtatcggtta taaggatcag gttcgtaagc cttttgatga atcccattta
     7741 caatgggaga agatacatat aggaaagttc tctcttccgg aagaaaataa agaggcggaa
     7801 gaatgagagt cgtatttgtt ggtgctggaa acttagctac ccggctttcg ttggaaatgc
     7861 gtaagtccgg aatgagtatc gggcaagtgt atagtcacac aagtgagcat gctaagattt
     7921 tagccgatga attgggatgt gggtggactg ttgtcccgga agatattgtg gaagatgccg
     7981 acttgtatgt tttctctttg aaagatgccg tgctccaaga tgttatcgcc cgtgtaaaac
     8041 cgaataacgg tttgtgggtg catacggcag ggagtatgcc aatctctgta tttgaaggtc
     8101 ttacggctag atatggggtg gtttatgcgt tacaaacgtt tagtaagagt agggaggtgg
     8161 atttcaagaa aataccgttc tttttagagg cgaactcgtc tgaagatgag aaggtgctgg
     8221 gagaggtggc tagggcgctc tccagtgatg tccgtttcct ctcctccgag aagcgaaaga
     8281 acttacattt agcggcggtt ttcgcttgta attttacgaa tcatatgtat gcgctagctg
     8341 aaaagatctt ggaagaacag caaataccgg gagaggtctt gctacctttg atagacgaga
     8401 cagccgctaa ggtacatgta atgtcgccgg cgcgagccca aacgggacca gctatacgat
     8461 atgacgagaa tgtgataaac aaacatatgg ctatgcttaa agatccggat atgcgaaatc
     8521 tatatgagct gattagccga agtatacata aggaggctcg acatgagtag tataaactat
     8581 gatttgagaa aaataaaggc ttttgtcttt gatgtagacg gggtgctatc ctgcgatgtg
     8641 attccgcttc acccgaatgg cgatccgatg cgtacggtca atatcaagga tggctatgcc
     8701 ttgcaattgg ccgtgaagaa aggttatgag gtcgctataa ttacgggcgg atatacggaa
     8761 gccgtacaga ttcgcttttc tcgtttagga atacaacata tttatatgcg tagcgctgta
     8821 aaggtgcatg actttaagga ttttatggaa aaaacgggct tgtctcctga gcaaatcatg
     8881 tatgcgggtg atgatattcc tgattatgag gtaatgacgc gagtcggatt gccggtggca
     8941 cctgcggatg cggctccgga gatcaaggag atagcgaaat atatatcctc ccggcgaggt
     9001 ggcgaaggcg tagctaggga cgtgatcgag caaacgatgc gggcgcaagg acactggttc
     9061 ggcgaggagg cttttgggtg gtaaaatttt ggtgaatgtg taacgcttaa tcgaataggt
     9121 tatgttagag aatttaaaaa agtacaagat cgtcttagcc tctaattctc cgagacgacg
     9181 gaatttgtta tctggtctgg atatcgactt cgaggtgagg ataattccgg atattgacga
     9241 gtcttacccg gattctattg actccatgga gatcccttta tatattgccc gttcgaaagc
     9301 ggaggcctat aaatcgacta tggcggatga tgaattgcta atcacggcag atacgatcgt
     9361 ttggacgttt gacggggtta tggggaagcc tgcgaaccgg gaggaagctt atgctatgct
     9421 tcatgctttg tcggatcatg tacatcaggt aataaccggc gtttgtatca tgacgaagga
     9481 caaaaatgta ggcttttccg tcgaatctgc ggtttgtttc gcaaaattgg gtgatgaaga
     9541 gattaattat tatttggata aatataaacc ttatgataaa gcgggagggt atggcattca
     9601 ggagtggatc ggttatatcg gggtagaggc tatcaatggt agcttttata acgtgatggg
     9661 attacctgtg caaaagcttt atcaggaatt gaaacatttt taatctcaat tcaaggtaaa
     9721 gtatttatcc ttcatataat attctatctg atttaatgtg tgcgctaagg ctgggggaat
     9781 cggtaagacg accggtttct ccacattcca ttccgggtca tttatgatca tgtcggatag
     9841 gctgcccgca tgtattaaga taaggcgggt aggggctgag gctataacct tatgattggt
     9901 gttttgcgca agtagcatga aatgatcttt tgccacttcc gctatatgtg tcccttcttg
     9961 gctgtaaata ataagttttc ccgaaaatac gaagattaat agattatccg tggttgtggt
    10021 attaaacagg gaatctccgg ctctcagtat tttgcattca agttgattta gataacgctt
    10081 catgtaggaa cttaaggatt ttcgaggata gccaatgttt ttctgttagg aaggtattcc
    10141 aacatacctt ttgagtaggt gactttctgt tgtccgttgt tgtccgcata aataataaaa
    10201 tactctattt gggggatgga ttgtgccagt agcttcgctt tctcgactcc caaaaccatg
    10261 aaagtcgtag cgtaagcgtc tgctgtcata caatcttccg ccacgatggt cgcgctaaga
    10321 atattttgtc cagcgggata accggtcgcc ggattgatcg tatgggcata tttcttacca
    10381 tccttgatgt agaagtttcg gtagtcacca gaagtagcca cacccccttt ttggcataat
    10441 tgtacgatct cttcaacatc atttgttacg ccacttgtcc ctatttccgg cttgttgatg
    10501 ccgactcgcc aacagtcacc ttgttgattt acgcctttca tggtgacctc accacctatt
    10561 tctaccatgt agttctttac gccttccttt tccagcaggc gggcgatgac atcgcaagca
    10621 taaccttttg cgatggacga acaattcaat agaatccggg gatcttcttt gatgattttc
    10681 tttccttcca atctcacttt ttgataaccg acgaaagcct ttatgctatc gatcatctgc
    10741 ggggttacgc tatccatctt actgaatccg aatccccata gattaattaa tggagcacaa
    10801 gtaatatcaa aagctcctcc tgatttttgg gagatttctt ccgccttatt gaatacttcg
    10861 gtaaaccatt cgtctacctc cacatcctcg ttattattga ctttcgcgat cgtggagttg
    10921 gggttgaaag gatttaagga gaggttaaaa cgttgcagct cgctgtcgat cttatcggtt
    10981 aggatttgct tggccttgta tttgatgtgg taacttgtat gaaaaacaga accactctct
    11041 tcgaaatatt ggcccttgtc cgagcaagcc gtatgcgata agatcaacag gctgactaat
    11101 atggtaatat tcttgcgcat cattatgaaa ttttatgtcg cgaacttaca taaaaaattc
    11161 catatatgcc cctttcatgg gggagacgct attgtgtgta taaatatcaa ggattccttt
    11221 tttatattgt gactctggtt ttatccaatg tgcacgcctt tcggatagga tcttttctat
    11281 ctcttccacg cttctctcaa tactgtcggt accgattata tccaatgttc tcgctggaat
    11341 atcgatacgg atcaagtcat cgttttcaac caaggcgatt ggtcccccct cggaagcctc
    11401 cggggataca tgtccgatcg ccgggcctcg ggtcgctccg gagaaacgac cgtcggtgat
    11461 caatgcgatg gtctctacca actcaggatc ggaggcgatc gcttctgtcg tataaaacat
    11521 ttctggcatt ccacttcctt tcggtccttc ataacggata aataccgctt ctcccggatg
    11581 gattttcttt tgtaataccg cctcaatagc gttctcctca caatcgaata ccctcgcttt
    11641 cagggtgact tgcatcaagc ggggtgaaat cgccgaatgt tttacgactg ccccttcggg
    11701 cgctaaattt cctttcaata tagcgatggc tccttgtgcc ttgatcggtg tatgaaaagg
    11761 tttgataata tcgccaacct ttactcctag ggcaggaaga tatttatggc aattctcata
    11821 gaagccgttg agttgtaaat cttttaagtt ttcttccaat gttttgccgg taacagtcat
    11881 gacgtcgaga tggaggaatt ctttgatttc ttccatgatc gccggtacgc ctcccgcata
    11941 ccagaaatat tcgccgggcc aaaaaccgct gggacgtata tttaaaaggt aggggatctt
    12001 acgatgtatc ttgtcgaaca aatccggtga taactggatt cccagttcat gggcgatagc
    12061 tggaagatga agcaggctgt tgctggaacc cgctatggcg gcatgtacca tgatcgcatt
    12121 ttcaaacgct tgtatcgtca tgatatcgga gggttttaac tcttctttcg ccagtccgag
    12181 tgcatgttct ccggctttac gggcggtttc ttttaactcg ggtaaatggg cggggatcaa
    12241 ggcggagccc ggtaaagcga tgccaagcgc ttctgccatt acttgcattg tagaggcggt
    12301 acccatgaaa gagcaagctc cacaatccgg acatgcgtca cgcttataaa ccatgaattg
    12361 ttcttccgtt atttcttttc gctcgtactg ggcgctatag gtaccgattt gttctaacgt
    12421 gagtaggttg ggaccggctt tcattatacc accaggcatg aatatagcag gcatatctag
    12481 ccgggctatc gccatcaaat gcgcagggac ggatttgtcg caactggcta taaagacacc
    12541 agcgtcgaaa ggagtcgctt ttacatgaat ctccatcatg gcggccatga tatcacggga
    12601 gactaatgag tagttcatac catcgtgtcc ctgcgcctct ccatcacaaa tatcagtgac
    12661 gaagtagttt gcggcacgtc cccccttttc ctttataccg attccggcct cgtccaccaa
    12721 tttatccaga tgggcgcttc ccggatggct atgtccgtaa ctgctttcta caatgatttg
    12781 cggtttactc aattcgtcga ttttccaacc gctgcctagc cggagtgaat ccagctccgg
    12841 cgctagtttt cgtaattgct ggcttttcat gtctattaat taatgtataa ggttatttat
    12901 tcaataaggt atccctagct aaagaataca tgctctatca aaatctttgt accgataccg
    12961 attaagatta aacctccgat gaggtccagc ttcaagtcga ttctcttgcc gaatcggtta
    13021 ccgaaataga cgccgaaggc agagatagcg aaggtgacaa caccgatagt cgaggcttgc
    13081 agcaagagcg gtgattttaa gatcgccaga gagattccta cggcgagggc atcgatactt
    13141 gtcgctattc ccaatccgca taatgtccgg ttacatagag gatcgaattt cccgtcttcc
    13201 tcctcttcct tcgcgctatc gtatatcatt tttccaccta agtaaagcaa gagggtaaat
    13261 gcgatccaat gatcgaaggc gcaaatgtat ttttcgaatc ctaatcccat cgtataacca
    13321 atcacggtca ttccggcttg gaatataccg agcacgctcg ctatcttaat aatattaccg
    13381 gcggtgcagt tgttcttaag aactgcgccg ccggtaactg atactgctag gctatccatg
    13441 gataagccga tcgctagtag cagaacttca atgtataaca tactagaatg attcccgttt
    13501 aataatttct tctatgggct tacgtttctt tggagtctca tcgaataatg ccgggtcgga
    13561 aggatagccg aacggtatca gtacaacagg ctcgatcgtt tccggaattt taaaatgttt
    13621 acggcaaagc tccgtgtcga aattgcaaac ccaacaagta cccaatcctt gttcggcagc
    13681 ggctaaacaa atgtgttccg tggcgatagc cgtatcgata tccatatgat ccttatgatc
    13741 gccccgtttc caagattgct gatgatctcc gcaaacgatc aagtaataag gcgcttgctt
    13801 gaaccattcc cggggatagc attcttgtaa tttagctttt ccttccgcac tttgaaccca
    13861 tacaaaatac caaggttgat aatttaccgc cgaaggggcc aaacgagctg cttctaggat
    13921 ataatcaatc ttttcttgct ctacgttttt gggggcatac tttcggatag agcaacgttt
    13981 tctcgctaat tctaggaaac tcatatctca tcctctattt tatagttatt gcgattcgga
    14041 gaattgcggg aaatcaactc cccgataaag cccgctagga acatctgggt tcccagaatc
    14101 atcgctgtca atgaaatata gaaataaggg gaacttgtaa ccaaaggtct tagatctcca
    14161 gagtacatcg agatcaattt catgctgagt acgattacta gagcgataaa accaatgaag
    14221 aacatagcgc ttccccataa accgaagaag tgcatcggtt tctttccgaa tttggaagta
    14281 aaccaaagcg tgatcaaatc aagataaccg ttcacgaagc gatccaaccc gaatttagta
    14341 gttccgtact tgcgggcttg atgtttcact actttctcgc caatcttgtg aaatccggca
    14401 atcttagcta aataaggtat gtaacggtgc atatcgttat acacctctat atttttaatg
    14461 acaacattct tatacgcttt caatccgcaa ttgaaatcgt gtaagttctt tattcccgag
    14521 aatttacgag ctgtcgcgtt gaataatttc gtggggatcg tcttagacaa cgggtcatat
    14581 cttt
//
