LOCUS       gnlProkkaDKGIHEGG_12   12324 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DKGIHEGG_12.
ACCESSION   gnlProkkaDKGIHEGG_12
VERSION     gnlProkkaDKGIHEGG_12
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 06:33:35
            Original ID  :: gnl|Prokka|DKGIHEGG_12
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 161981
            Orig. end    :: 174305
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12324
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:9314]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9314
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12324
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12324
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(162..1202)
                     /locus_tag="ctg12_137"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
     CDS             complement(1206..1952)
                     /locus_tag="ctg12_138"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKKF"
     CDS             complement(1961..3220)
                     /locus_tag="ctg12_139"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             complement(3174..4658)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_140"
                     /sec_met_domain="Polysacc_synt (E-value: 1.6e-30, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             complement(4861..5004)
                     /locus_tag="ctg12_141"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             complement(5001..6122)
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg12_142_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_142"
                     /sec_met_domain="Aminotran_5 (E-value: 1.8e-30, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        complement(5025..6032)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg12_142_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg12_142_Aminotran_5.1"
                     /locus_tag="ctg12_142"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             complement(6132..7256)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_143"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-19, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-19, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             complement(7273..8574)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_144"
                     /sec_met_domain="CTP_transf_like (E-value: 2.2e-12,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 2.3e-120, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.6e-62, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             complement(8595..9314)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_145"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.2e-16, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             complement(9378..10526)
                     /locus_tag="ctg12_146"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             complement(10541..12322)
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 71.6;
                     E-value: 8e-22)"
                     /gene_kind="transport"
                     /locus_tag="ctg12_147"
                     /transl_table=11
                     /translation="MTSDIRLTLGNIRTIQINVMGEVVQPGTYALSSFSTVFHALYRAG
                     GVSDIGSLRNVQLVRNGKNIATIDVYEFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISG
                     KVKRPMRFEMKKDENLATLIKYAGGFEADAYTRSLRVVRQNGEEYEVNTVKDMDYSIYT
                     MRNGDVVTAEAILNRFTNKLEIRGAVYRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNR
                     AVLYRQREDLTSEVVQIDIRSIMDGTSPNLALMKNDILYIPSIHDLEDRGNVTVYGEVA
                     QPDSYPYADNMTLEDLIIQAGGLKEAASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLK
                     DGFVIDGQPGFILQPYDEVYVRRSPGYQAQQNVVIDGEILFGGNYAMTNREERLSDLVN
                     KAGGPTNLAYLRGAKLTRVASAGEKKRMGDVIRLMSRQLGEAMIDSLGIGVEDTFTVGI
                     DLEKALTNPKGSADLVLREGDVVFIPKNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQA
                     GGYSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVPGKAKKKGNIANILGYATS
                     FSSLGMMIASIANLIKK"
ORIGIN
        1 atcataaaac attccgccat cagtccaaac gccatcaata tctgtaagta taagctttat
       61 ctctttcatt tttttagtat tttaccctta tttattaatc actacttagc ttatagcagg
      121 cagtactcta taccgtaata caagttgcag taggaatata tctattcaat aaaatcagga
      181 tatattattt cattcgctga tatatcttgt ttagcaaaat gaccaattac atttttttta
      241 tctatccatt tataaccatc accaggactc agtaaatgaa tgtccgactc ttgaataata
      301 ctacctgctg gaatatattt tcgagtggca atagaacgtt caagttttat cttagacttc
      361 tccacccctt tttctatata aagatcttca gtaccaagcc aacactctgc tatgcgaata
      421 tctcgaatca tacgattaac cccatctgga cctaaagagc caagctggtc tgttcctttc
      481 atatgccgat caattgttac atgcttttct ataatttccg ctcccatcgc tacagcagct
      541 gtagcagcag aaatacctat tgtatgatca gaaaaaccta tctcaaactt attgtaatgc
      601 ttcttcaaat atgttattgt acgtagattc aaattatttg gatgagttgg atactgagat
      661 acacaatgta gaatagctat attactatga tatctcgtta tcacatctaa tgcattgtca
      721 agttctcttt gaccagccat tcctgtcgat aatataatag gaatatgagt ttctgctaat
      781 gcttcaagca atggtaagtt agtcaaatca cgactagcaa cttttagcct atccggtgtg
      841 aacagtttaa gcaaagacag acatcctttg gcacataacg tctcgataaa atctaatcct
      901 aatgacttag catatttata aatctcaaaa tgcgcttgat catcaagctc aagaaaagca
      961 cgatgttcac cataagtacg cccaaaagaa ttaggattgt catatatttg attcatttga
     1021 gaaacagcca attcttctga taaatctctt ttagtcattt taacagcatt cattggcatg
     1081 aaatccatac caaaaacatc ctcatgtaca ggtcgtgaga ttaattcaat aatcaactta
     1141 gccaagtcaa cagaaccatt atgattctgc cctatttcac caataatata agtattcttc
     1201 attatttaga attttttttt tatttgttgt ttcatcagtt gaatgtattc tgcatgtctt
     1261 cgaacatagt ctacaatcac ttctatcgat atttccactc ttttttcttg taaatcccta
     1321 tatattctct gtgctacaga aaaatcttct aacgtatcaa tcgtgagtcg aatattatga
     1381 tgttttgaca cgactggaga tcctgaaatc cattgaatat taaaaagttc aggatgacta
     1441 tatatataat tagtaacatg ttcacgatac aataaatcat cagtaaatcc tataactcgc
     1501 ttcagcgcat caagcgttac aaattctccc caaaaaccga aatgagtttt aattgatgga
     1561 gtaccatcaa tatcaaaact tatataatcg ttacaagatt tcattgctat ttcgaccaat
     1621 tgccttgccg catgtacatc taaaaatgga ttatcagaac atattcggaa tataccctgt
     1681 atatcaaaat attcagcaac atcaatgaat cgttttaaaa catcattctc ctcacctctg
     1741 aagcacttta cccctaatgc aagtgccttc ttttcaatag gttcattgat aacagaattt
     1801 gttgtagcaa taattactgg aatattcgat atagcagaaa gcttatgaac cattaagtca
     1861 agaatcgatt gattaccata gaaaggtttc aatatttttc caggcaaacg tgtagaacct
     1921 aaacgtgcct gcaccacaaa tgcataattc attttattta ttatatttca tttaaaaata
     1981 tgtcacatat tctctttgtt gaattatcat cttgaaattg attcatcaat aaagaaatat
     2041 gacgtcgatg ttcagcatga atatctttcc cagccagaag tcccatcaca gcatctatca
     2101 attcattata attgtaaaca atatcacctg cacaaaaaaa ttctattggc tcaaatgaga
     2161 aacctcttac tctacgatat tcttcaatat cgtagaaatt aaatatgact ggcttattta
     2221 ccaataaaaa atcaaaatag gtagaagtat aatcagtaat cattccatct gaaaatgaca
     2281 aaagatcata caatccatat ttatatgttt gttcaaaaac aagtatacct ttgggtaaat
     2341 ctttttttaa gactgtttta ttctgcaaag gatgtaattt aagaattaaa gccgcattaa
     2401 acttcaatag tattttcgat aacttcaaca aatcacaatc aacatatccg agtattgaac
     2461 gcaaattacc ttcagtaaca gtctcataat cacgaaaagt tggagtataa actatatatt
     2521 tagttacatc atatcccgca aatttcgaaa tttctctttt aataacattg caattatttt
     2581 tcgatatcaa caaatcattt ctgggaaatc ctaagacttt gaatttatca tatgagattc
     2641 cacaatctat tgaaattatt ctagcactta aacaagaagt agcaatagag taatcaaatg
     2701 agttacatgt tgtattacga aatttatcat aagaatgatc tcccatatga taatcatctt
     2761 tgaatggagt ataatacccc aaacaaataa tctgttgaga gcgtttttta aatgaaaaat
     2821 cataataaaa agtagctgta aaacatttac ttgctctaca aaaacaaaaa aaggcataca
     2881 acatatcctt aaaagatact ttattaaaga aaaaacgtcc aacacatgca cataaaaaag
     2941 tacacctaat attaggattt atgccataaa tatattcttg atattctgaa atacgagaag
     3001 aatcataaat ttcaacatat attttataat attcagcact atcttttttt agcaaataat
     3061 ttaacagaac gagaacatta tctgacgaat aatttataat atcatattta tctgttctac
     3121 aattaggatg aggaataaaa tacaatgatc tactatcaac tggcacacaa tggttaatta
     3181 tctttactat tacttgaaaa atctttttta atattttcat ctatgttttt agttttaatg
     3241 atcaatgtta aaatacaaaa aaaagaatct agcttaaaaa gaaaagaaag taaaatatag
     3301 aaggacatcc cagtaataca tccaatcaca atttttacta tatcagtttc aaagaaagaa
     3361 atacatataa aaacgatccc ccccattatg aaagagagta ttaaacttgg aaatacatct
     3421 ttaacttgca actttaaggt caaatcaata agagaattag tataatatgt attcaaatat
     3481 gtcgctatca gagagtaaat aactctaccc caacacatca cctcaagccc aaatggaatt
     3541 gacacaaaaa gaatgaatat agcaatcgtc ttttttatta tttcaagacg taacgacaga
     3601 tcagatcttc ctttaaccca taataaattc aaattaattt ggctcaaatg atcaaacatc
     3661 caatccaaac ataatatctg taaaagaata acaaccccag accatttatc tgttaacaat
     3721 agactaataa taggattagc caaaacaagt aaacctacca ttaaaggaaa aattatatat
     3781 gaggataatc tgatataatt tcgatatgcg tttgttaaac atttatcatc atcttgaatg
     3841 gaacttaaaa taggatacgc tactctagaa actaaagcat ttaaattatt ggaaggaaaa
     3901 atagcaaatt gttctgctct tgtatagtaa ccaagctcta caacagaaaa cttttttcct
     3961 attacaatgg tatacagatt acgatatact gtattgataa gacttgagat caataattta
     4021 gatccgaaat tgaataatct ttcaaaagaa cttttggaga aagtatgtaa aggtttccaa
     4081 tgaactaaac agtaaaacaa aattgtcaaa attatactat ttaagagagt ttgccaaact
     4141 aaagcccaaa ccccgcaacc gacataagcc atccatattc caatcacgcc tgatataaaa
     4201 gctgcaccta atgaaatttt agattgagtt ttaaagttta cagaaataat taatttcgtt
     4261 ctgtgaatag ccgataaagc atttattatc aacgacaatg ctataaaacg aattacaaga
     4321 actaaagtcg gcatattata aaagtctgca atcaaagaag ccgaaaaaaa caatatacca
     4381 tagaataata ctgcgacaag aatattaaaa taaaagacag tggcaaaatc ctcttcagtt
     4441 ctatcttttt tctggattaa agcatttgta aaaccgctat ctataaatac ttgagcgact
     4501 tgaagaaaaa tagctaacat cccgatcata ccataatccg atggtagtaa caaacgagct
     4561 aatattattt gaattataaa ctgtactcct tgtaaagaga aacgttctat agcgctccac
     4621 attattcctg atacagtttt ctgctttaga ttttccatta cttaaataca gtataaaaac
     4681 aactacattt accgatatca attatatttt tccaatattc tcactaattg gttattatct
     4741 tcttcgcccc ttaccgcaat tctaatatgg tctctcccac taaaagcaaa ttaccctaca
     4801 caaacattat ctcctataac taccgatgcc tttttataag aataaagaac tcctaatgca
     4861 tcacctcaaa ttaatattgc catatttgcc tactaagcga aagctacgaa taggcactcc
     4921 agaaataaca ctttccggat ggaagtgtat accacgaagg gaaaaataaa aatgacgaat
     4981 cttcaataat atttctgcaa tcatgacatc ggtaatgtga cgttataatg atttaatgca
     5041 gcttttagta ctttaaagaa gttctcaata tcatctactt ctatctctcc taaagcacag
     5101 attctaaaag tatcctcagt tgatatctta cctggataaa tcgtaaatcc acgctcataa
     5161 caataatcat gtattttctc aaaatcccag ttgggatctt ctgggtattg aactgagaca
     5221 accagtcctg actgccattc acgctttatt acacttttaa gaccaatttc atttatacct
     5281 gaatgaatag cctcaaaaac tcttttgtga cgggcaaact tagcttcttc acccacttca
     5341 aaatattcat ttaatgcctg acgagtggcg taaatagttt gtaccggtgg agtaaaatgc
     5401 atttcacctg ttctctcaaa attctcatac tgcaaataaa gattacaata gtaagaacgc
     5461 ttgggatatt tttttgaaaa cttaatctgt tcctcattgc ctataataaa agaaagacct
     5521 gtcatcgctt gaagtccttt ttgagcagat gccatacaaa aatccacatt atctttctct
     5581 atatcaaaag gaatcatgcc caaagaagaa gtagtatcga cgacaaattt agcctgatat
     5641 ttatgagcta tagcgcccat ctcgcgaata gggttcagaa ttcctgtacc cgtctcgtga
     5701 tgagtagtat aaaccatagc tatatcagga ttttcttgca acacattttc caccaccgat
     5761 aaatcaggac gttcgtaaac ggaaaattcc aaattaatat gaggcaaacc ataatattga
     5821 cacacttcta cagcacgggt actatatgcc ccattattca ctataagcac ccttttgtct
     5881 tcaggaagaa gagaatttag acatatatca atattgatgg ttcctgagcc acaaaataat
     5941 acagcggtat gtttttccaa attcccatga gcaactctga ccaaatcgtc ccgaagttgt
     6001 ttcatcatac ctgcgaattc tttctcgcga ggacaaatat ccggaacaac ttgtgccatt
     6061 tttacactgt cagtagtagt ggcaggccca ggatttaata atatttttct ttctattttc
     6121 atcgaatata tttattttaa aaaatccata aaatgctcct tattctctat aggagtagtc
     6181 gtgggacgtc ccaaattctc ccgagaatct attttaacct ttatttccaa caaaacagga
     6241 ccacataact ttggaagctg cttcattgct tcttcaattt caacttttgt acaaacagta
     6301 taagtatgct tatatccgct cccccggaca atagccggaa tatctaaact aaatcctaaa
     6361 gtaggctgtc ctcctacaga ctcgtgagca ccattgttaa acaaaatatg ataatagttt
     6421 ttaggagata aatcgccaat gttactaatt gcccctaaat gcataataaa tgctccatca
     6481 ccatccaagc aataaacagg tctatcttgc tttgctatag caatacccaa agagattgat
     6541 gaactatgtc ccatagagcc taccgtgaga aaatcatgtt catgaccttg ctctttcatt
     6601 tctcgatatt caaataactc acgagaaagc ttgccagtag tagaaacgac cactgaattt
     6661 tcaggcagat aatccacaac tatttgcaaa gcatcctcac gagataaagg ataattacat
     6721 ccgaactctt tttgaagttt atatttgcca aaaacatctt tccgaataat tattgcatga
     6781 ggaatattct tagtttttgc tgattgtatg atatcatgga gctgaataaa tgcatcattc
     6841 tcatttgaat caagaattat ataaggaatc cgcattgctt tcaacaaatc taaagttacc
     6901 tcaccctgtt ttttatgctg aggttcatct tttgttcccg gttcaccacg ccagccaatc
     6961 atcaaaagca ttggaaaact gtatacttgt tcatctgcaa gagacagcag aggattaaca
     7021 gtattaccca agccggaatt ttgcatataa accacaggaa ccttacctga tgccatataa
     7081 taacctgaag caattcctac agccgcacct tcattagcag ctatgatatg tttctcacgt
     7141 gaagtatggt ctgtgatata ggcacaaata ttttttagta atgagtctgg aactcctgta
     7201 aaaaaatcaa cgtcatgact cagaaacgtt tcataaactt tttctacgct taacataatg
     7261 atattcctct ttttatttag tacctggaat cagttccaat atttctttta tgggcataca
     7321 cagttcgcgc acctctaaag cacgttcatt ctctaatatt atctttgcga cattcatcat
     7381 agcaggataa gcggcacgaa gcatatgatt agcataaata attatattca caccccaatc
     7441 acacaattca gactcataaa tatgatcata tgtagtaggc acaaccacga taggtacatg
     7501 agcatactgt tttcgaaacg ccaaacaaaa ttcttttata tcttcacccg acttattttt
     7561 gctatgtatc ataataccgt ccgctcccgc ttggacatat gcaaaagctc tctctaaagc
     7621 atcacttacc ggctttcccg ctataaggct ctcaatacga gcgataatca taaaatcatc
     7681 agtaatctga gatgcctttc ctgctttgat cttattacag aaaccttcga ttgtatcttg
     7741 agtttgaata acatctgtac caaacaatga attctttttt aatccaactt tatcttcaat
     7801 tattatagct gaaattccat gacgttctaa agtgcgtact gtaaatacga aatgttcaat
     7861 tttaccacct gtatctccat caaaaataat aggtttagta gtacactcca gaatattatt
     7921 caaatcttgc aatcgggtag ttaaatcaac cgcctcaata tcaggtttac ctttactggt
     7981 tgaatccgta aggctactag accacattcc gtcaaatact tccctcttat ccccttttaa
     8041 tatttcctga ttttcaatta tcaagccaca tagtccatca tgagcttcca aaatacgaac
     8101 tacgggtttg gcatttatca aacgacgaag tgattttaaa cgtacatcag gggttgtacc
     8161 tatagcctta atatctttat ccaaagaaga tgaattaatt cccaaagtat atggaatttc
     8221 gataaccttt cctccctgtt cattcatcac ttcaaatacg cgcacacgtt cttcacgtaa
     8281 aggcccggtt ttccagtcgt caccatgaat tatatagtca ggtttaatgc gtttgagatt
     8341 ctcaacatag ctccattctt cttgaggaac aactttacat acgcctttaa tattctgaac
     8401 tacctctttt cgttgttcat aggtcagata aggaaggcgt ttatgctccg caatagcttt
     8461 atctgtaaga agaccaatta taacatcacc gtatttagta gcctcattaa taatgcggat
     8521 aagtcctgga tgcataatat ccgcagtcat cccaatataa actgtcttac tcataatttg
     8581 atatattatt ttaattaaca atacggaaca atatatttct ctgcatattc caaatctgat
     8641 atgtcatcga tttcatacca tttcagccct tctactttat gcacataaac aggagattga
     8701 gaacaagata ttcgtagtaa ttcatactca tatcccaaat tgggttgttc atcaacaata
     8761 ctcgcataat cagcacacat tattttgtaa aaggaaccgg atagtttatg gatgccgacc
     8821 aattcgcctt tagcgtttag tttattctta ttgacagaac atgaagaaag gcgaaaatta
     8881 tcatcatgtt ccacataata ctgatcttga aactttgtca ctggagctat tagcattgca
     8941 tctgccgcag gacactccaa taagctcatt attgcttgtt tctcaaaaat caaatctgac
     9001 tctaacaata aaaaatcatc attgcccaga atctcccgcg tattatataa agtatacata
     9061 ctatttgttt cagcataacg aggactaaaa caggtttcaa gcataggata gtctgtcttc
     9121 aattcttcat aaacttcttg tttatatcct gtaccgatta caattcgctc aatgccacat
     9181 gataacaaag tatcaataga acgaactatc attggaatac ctcccacttt gacgaaccct
     9241 ttaggtatca attctgtata ttggccaaaa cgggttccca tgcccgcagc cattatcata
     9301 gctgtacgta tcattcgttt aataatatag taagtgaatt taattgatgt aagaatgttg
     9361 taaacgacgt tttagcatca tttatcctgt tctatctcct tatttttcag ttcttttctc
     9421 aagctagcca gcagactttt gccaaaaaac acccacacga gagtaccaga tacggacagg
     9481 aacacaaata ataaaatata aattttgagt cccatacctg aaggtttcaa aggtacaacg
     9541 gcaggctcaa ctactgcaaa gactggcttt tcctcctgta ctttggctct ggatacctgc
     9601 aactgattag caacctgact atatatctga taagccaaac tcatgtcgtt ctgtaaacgc
     9661 tcctgctcag cacgtacact ttgaagaacc acattatcat gggcgtctac ataatccgca
     9721 tattttcttt gagcagcata atattcctgc tgacgttctt taaacaaccg ttccaaatac
     9781 gcacagtctt cttttacttt tgaagttcga tacccaataa tatattcctg taatttatga
     9841 acgacagaat ctgctataac cgcagtgatc tgcggatttt gtaaggtgac cgtaatgctc
     9901 gttatggcgg ttttcttatc aatggatgca ctaatcttct ttttaagaaa attaatcttc
     9961 tcatttactt ctttcgtcaa ttcgatagtt ccttgccgcc ctccactggc aggaaccgta
    10021 tcttctccga ataatgattt aactcctcct attactatgc ccggaaaacc tataagataa
    10081 tcccaccaag gagatgactc ttcatcgaga taagacccca aagtcatttt atcatccttt
    10141 ttagaaacgg agacttccat ttctaaaagt tccaataaaa aaggagttga agaaacaata
    10201 tctgctgaaa gagaagcgtt caaggcatct gtgctttccc ctattagagc cccatctcct
    10261 aaaaacgagg cagcaagtcc ggctaaacca ttactcccct tcgcattacc catttcagga
    10321 gaaagggtaa cctttactgt atactgttta gggatactta ccgctacaat tattccaata
    10381 ataaaaccaa ttccaacggc tttgtataat tttttacgaa tagcaataat cttgcgaaag
    10441 atatcgacca aatcaatttc tatctcatca ctttctgtct tgtgtggttc agagagcaag
    10501 tttttatcct gtcgttgttc tgacataaaa gtaaattcta ttatttcttt ataagattag
    10561 caatagaagc aatcatcatt cccaaagaac tgaaggaagt agcataacct aaaatattag
    10621 ctatgttccc tttcttctta gccttaccag gcacaataat ctcacatccc ggctcaatct
    10681 gtttcttacc actaccctta accttcgtca cctgaccatt catgtaaaca atgaatttct
    10741 tactcttcct tgcattatca gaataaccac cggcctgatt caggtaataa tccacattct
    10801 tgcccttcat ataagaaacc gtattcggaa ccatgacagc accattgata gttacagtat
    10861 tagtattctt tggtatgaag accacatcac cttcacgtag gacaaggtcg gcactaccct
    10921 taggattagt caaagccttc tccagatcaa tgcctaccgt aaaggtatcc tcaacaccaa
    10981 tacccaaaga gtcaatcatg gcctcaccca attgtctgct catcaggcga atcacatcac
    11041 ccatacgttt cttctcaccg gcacttgcca cacgggtcaa tttcgcacca cgaagatagg
    11101 caaggttagt aggaccaccc gctttattca ccagatcgga aagacgttcc tcacggttgg
    11161 tcatggcata atttcctccg aaaaggattt caccatcaat gactacattc tgttgtgcct
    11221 gataacccgg actgcgacgg acataaactt cgtcataagg ctgaaggata aaaccgggct
    11281 gaccgtcgat gacaaaacca tcctttaaag agaaggtata catctgaccg atagtatcat
    11341 tatccgcggt actacgggga ttcttgattc gtctcgacac atcaatgcgg acagtggagg
    11401 cggcttcttt caagccaccg gcctggatga tcagatcctc aagtgtcatg ttatcagcat
    11461 agggatagga atccggttgg gcgacctcac cgtaaactgt aacattgcca cgatcttcca
    11521 gatcgtgaat gctcggaatg taaaggatgt cattcttcat cagggcgagg ttcggggaag
    11581 taccgtccat gatagacctg atgtctatct gaacaacttc actggtcaaa tcctcacgct
    11641 ggcgataaag gacggcacga ttcaggaaag cgtcaccggt caggccctgg gcttcatgga
    11701 caagttcgcg gatcgtgttc agtttaccgc tgagctggta gatgccggga cgatagacag
    11761 cgccacggat ttccagtttg tttgtgaagc ggttaaggat ggcttcggct gttacaacgt
    11821 caccgttacg cattgtgtag atgctgtagt ccatatcctt gactgtgttg acttcgtatt
    11881 cctcaccatt ctgacggaca acacgtaatg aacgggtgta ggcgtcagct tcaaagccgc
    11941 cggcatattt gattaaagtg gcaaggttct cgtctttctt catttcaaaa cgcataggac
    12001 gttttacctt gccgctgatc tttaccaaga catcgtaggc ggggacgata accacgtcac
    12061 cttcctgaag gcggatgtca tcctgtgtgt tgcctttcat gataaattcg taaacatcga
    12121 tggtggcgat attctttccg ttgcgtacca actgaacgtt tcggaggctg ccgatatcac
    12181 tcacgccgcc tgcacggtaa agcgcgtgga agacggtaga gaaggaagaa agggcgtagg
    12241 tacccggctg cacgacctct cccatcacgt tgatctgaat agtacggata ttacccaaag
    12301 tcagacggat gtcggaagta gggt
//
