LOCUS       c00012_gnlPro..        16136 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OHMELMBN_12.
ACCESSION   c00012_gnlPro..
VERSION     c00012_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 13:33:26
            Original ID  :: gnl|Prokka|OHMELMBN_12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16136
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..144
                     /locus_tag="ctg12_1"
                     /transl_table=11
                     /translation="SRMYRNIILDSHLIIYRITEERIEVLDIVHSASSMRKIKKTKNIH
                     IE"
     protocluster    1..16136
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[213:6136]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      214..6136
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..16136
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16136
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(214..1257)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_2"
                     /sec_met_domain="IlvN (E-value: 1.4e-46, bitscore: 150.9,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.3e-39, bitscore: 127.8,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQMNFGGVVENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRQGKTYEKAVEDGWVPGETLFGIEEACDKATIIMCLLSDAAVMS
                     VWPTMKPYLTAGKALYFSHGFAITWNDRTGVVPPADIDVIMVAPKGSGTSLRSMFLEGR
                     GLNSSFAIYQDATGKAMDRTLALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYANVKCGNEAQISIDSNSKPDYREKLEAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(1307..2032)
                     /locus_tag="ctg12_3"
                     /transl_table=11
                     /translation="MEKVGLFHFVAEPYLMDFRGRVTLPMIGNYLIHAASSHAGERGFG
                     FNDMSERHTAWVLSRLAIEMKEYPTAFDKINLYTWIDEVGRLFTSRCFELADENGKTFG
                     FARSIWAAIDVETRRPTLLDIEALGKYIDERPCPIEKPGKIMPAENKAEGIPYSIKYSD
                     LDINGHFNSVKYIEHLLDLFDIDQFKTREIGRLEIAYQSEGKQGMPLTLHKAESAPDKQ
                     DMAICHEGKAICRAAVTWR"
     CDS             complement(2039..2593)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_4"
                     /sec_met_domain="ALS_ss_C (E-value: 1.3e-16, bitscore:
                     53.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKLYTVIIFSENIVGLLNQITIIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDMIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEGLIRKYNARILEMNETCVVLEKSGHYDETQALFNELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLADMERKLQEKQQ"
     CDS             complement(2609..4312)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.1e-50, bitscore:
                     162.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LRHVLVRHEQGATHAAQGYARVSGKVGVTLVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRKPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVEYEYKKVDYVRSYQPEPDINKDRIKAAADLINEAKKPFCLVGQGVLLGG
                     AEEELKAFLQKNDIPAGSTVLGLSALPTDFPLNKGMLGMHGNVGPNRKTNECDVLIAIG
                     MRFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVAVDVKVLGNAKHTIPMITALLEERK
                     RPEWNAEFDRDEKEEYDKVIEKELYPTEGQLKMGEVVRKVSEATGNDAVLVTDVGQNQM
                     MGVRYFKYKQTRSVVTSGGLGTMGFGLPAAMGAKFGAPDRTVCFFTGDGGMQMTIQELG
                     TIMQEKLNVKIIILNNNFLGMVRQWQELFFHERYSNTIMENPDFVAIAKAYGITGRAVE
                     KREELDDAIAEMLNHDGAYVLVANVETCGMVYPMVPAGGSVTNMIMGDEK"
     CDS             complement(4346..6136)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_6"
                     /sec_met_domain="ILVD_EDD (E-value: 3.2e-216, bitscore:
                     711.6, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGARALWRANGMKEEQFGKPIIAIVNSFTQFVPGHTHLHEIGQL
                     VKAEIEKQGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVC
                     ISNCDKITPGMLMASMRLNIPTVFVSGGPMEAGELDGRHLDLIDAMIESADTSVSDERI
                     EQVERHACPGCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHKNRIQLFRDAAKQIV
                     ENAYKYYRDGDDSVLPRNIATRQAFLNAMSLDIAMGGSTNTVLHLLAVAQEAGADFHME
                     DIDMLSRKTPCLCKVAPNTHTYHVQDVNRAGGILGIMNELMKAGLVDGSTRRADGLTLA
                     EAVDKYAVTSPNVTEEAIRKYKSAPAHRFSIQMGSQESYYKELDTDRAEGCIRDVEHAY
                     SKDGGLAVLRGNIALDGCVVKTAGVDESIWKFSGPAKVFDSQDAACEGILGGKVVSGDV
                     VVITYEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHISPEAAS
                     GGAIGLVRDGDIIEINIPERSINVRLSDEELAERREAEEARGKKAFTPPTRQREVSKAL
                     RAYGKMVSSADKGGVRIVED"
     CDS             7311..7895
                     /locus_tag="ctg12_7"
                     /transl_table=11
                     /translation="MGERNKHIENLRKGNRSSFEYLYTVWSGKLYNFVMKISHGDSYLA
                     EEMVQTVFLKVWKNREQLDPKLSFGAYLCTIAKNLLTNHYQHKMMEILYIEQQIDHPGT
                     PYARGTDEIVEYHLLEEFVDSLIQQMPEGRQRIYKLSRQSHLSNREIADQLQISENTVE
                     SQLTKAISFLRKRLKDQYDLGLLALSCLLNS"
     CDS             7969..9000
                     /locus_tag="ctg12_8"
                     /transl_table=11
                     /translation="MERNDYIHIFNKFLENKATPSEIKLLIEWLKERKAFDTWADDIWM
                     QSPMEMDPSVKQHLLDELRKQIFFKETGKRTFMSLSLPSLFHYALRITAIILLLITTSI
                     VTYHYAMDKQREPMDMIVAVEKGQKANITLPDGSKGWINSDSKLSYGSRFNADERVLNL
                     EGEAYFEVKPDAKRPFIVQSGKVSVKALGTSFNVKNYNTEEHISVVLMTGKVEVTANDN
                     HVDLLPNEQAIFNKHSSILGKNRVDNSLDYSSWMYNTLNFESTPFSEIAHTLERYYNTQ
                     IVFKSEALKSYRFTGKPGNTSLASILHLLSLTSPLAYEIKDSVVILYENNDKKELYNRV
                     LKQ"
     CDS             9226..12639
                     /locus_tag="ctg12_9"
                     /transl_table=11
                     /translation="LAPSLYAQISLDVQDQSIRHILKEIEKAGEYKFFYNSDLSNLDHK
                     TSISVQDKNIDEVMSLLLANTEISYKKEANNMIVLTIKSSSSPQAPRKTRKITGTVVDP
                     DGLPIIGANVIEQGTTNGSITDLDGKFELIITENAILNISYIGFSDKQITVKEETSLQV
                     TMTEDTQKLDEIVVVGYGVQKKVNLTGSVSAVKGEELSQRPVANATQSLQGLVPGLTVS
                     NSNSGRPGASGALSLRGQGNLANTANPYVLVDGVEMDLADVNPNDIESISVLKDAASAA
                     IYGARAAYGVILVTTKKGEEGKMRISYQGTVGWSSPTVMPEMANAYDYATFFNQACTNA
                     NVIKQYNPEKLQQLQQYMKDPASVNPWAELNGENNLVGAFENTPKGLGNVDYFDLHYKN
                     SAFKQNHNLSLSGGGKKAQYYISTGMYTEDGILRYADIKYKRLNFNANIASQITDWLNL
                     KVNTKFMNSDNDTPFGKGALSEGFYHSLARFRPTISPIDPNGHFTELTMIPYLQSGTYT
                     NTQKNNLTLTGGLEAQPIKNWRIFFDYTYRQNNENYEALNVAPMIPGADNETLYKGTRQ
                     ELGVMENGQFTRSSALSQYQSINLYSNYMFSLADKHNFTVMAGYQEENYAYSYLYESVT
                     DMISTNNPGLNLGTGEKSTTDTRNGWATRGFFGRINYDYDGRYLLEVNGRYDGSSRFAS
                     DHRWGFFPSVSLGWNITRESFMEKSLEVLSNLKLRASWGLLGNQSGAGLYTFTSIMGIQ
                     PLGNWYFQDGRDMYINAPGVIDPFTTWEKVESKNLGLDFGFFNNALTGTFDVFQRDTKD
                     MLGPSADLADFFGAEAPNTNNARMRNRGWELSLQYRGKIGKDIHYSIGGSLADATSEVT
                     AYENPTGTNPQDNWYVGKKVGEIWGYKASGLLQTQEEADTYNNTYDLSFLSGQKWMPGD
                     VKYMDLNNDKKINNGNNTLEDMGDMCVIGNTTPRYQYTLNGSISWKGISLSMMFQGIGK
                     RNWSPDLGTVYFWGSGAYAQVTVFNDHLDYWTPENPDAYYPNPYTGAAGSINQFRNKTS
                     QKSDRYMQSAAYCRLKNLTISYDLPNSWSQKIGLSKAQVFFSGENLLTFTKLPSMFDPE
                     AIFTGNDYTSEAGKNYPMNKVLSIGVIVNL"
     CDS             12654..14483
                     /locus_tag="ctg12_10"
                     /transl_table=11
                     /translation="MKRIYLSMVSLCLLGLCSCFDMDKYPEGELSSVNSFTSTTEITKY
                     LNQFYESTLKINDKDVANSAIKVQSNSIGNPTGIAFGDLNSDNMQSNVIDTRLAGETTL
                     SSAVELTEYKHIRSLNFLINNLDNCEEIGPEMEQCIGEAYFFRACYYYRLFVNYGEVTW
                     LTKVLDPIQEQMERPRNSRLEVADSILADLDIAIEHLNTQTNSSTMRVHKDVARALKSE
                     VALFEGTWEKYHRAKNTPFYDKKVTDEKISSYLRQAADAAKDVIDEGVWSISKGDPNTA
                     YRDLFITLDLSHNPEVLWWKKYDAANNIGHSVTRYLNKGGGTCGASASLVDDYLTKEGK
                     PFVGSERDKAKVMYGDELSPDLRDPRLSQTICMPGQDLRPNGEFVFKLPPLNEESRNQN
                     TTGYSILKYVEYNTTYIPTIDGEGKSQAPAIQFRYADILLNYAEALAELDGAANASKIK
                     EALRPLRERVGMPEMDFDREFNTDPDYPFNKLDKYIQAVRRERRIEKALEGSRLQDILR
                     WAAADILIIGKTPTGALFKGSSLETAYGESLQEGENLFLTGTPSDSKRYIIPFNNKHYP
                     NGWQFNPERDYLLPIQPRMLSLTGNQWVQNPGW"
ORIGIN
        1 agccgcatgt accggaacat catcctagat tcacacctta tcatctaccg catcaccgag
       61 gaacgcatcg aggtgctgga catcgtccat tcagcatcca gcatgcgaaa gatcaagaaa
      121 acaaagaata tccacatcga ataacacaaa gaaaggcgag ccacccgtaa gtgacccgcc
      181 tctttttgct gatatataag gattaagatt ggattagttg ttctccggac gaagcttgcg
      241 tacagtaaca gctgtctgcc acatctcgct ctcgcgcaat gccttcaatt cagcctccaa
      301 tttctcacga taatccggct tagagtttga gtcgatagag atctgagcct cgttaccgca
      361 ttttacgttc gcgtacaatt tctcgacaac cggcttgatt gcgtcgtgga acggacccat
      421 ccagtccaaa gcgccacgct gggcagtcgt agagcagtta gcgtacatcc agtccatacc
      481 gttcttagcg aacaaaggca tcaaggattg agtcaactcc tcgaccgtct cgttgaaagc
      541 ctcggaagga gtgtgtccat tctcgcgcaa tacctcatac tgagccaata acaaaccttg
      601 gatagcgccc atcaaggaac cacgctcacc agtcaaatcg gaagtagcct cacggatgaa
      661 agtcgtctcg aacaagtagc cggaaccgat accgataccc aacgccaacg tacgatccat
      721 tgccttgccg gtagcgtctt gatagatagc gaaagaagag ttcaagccac gaccctcaag
      781 gaacatggaa cgcaaagacg taccagaccc cttcggagcg accatgatca cgtcaatatc
      841 cgcaggagga acaacgcccg tacgatcgtt ccaagtgatc gcgaaaccat gagagaaata
      901 cagagcctta ccagctgtca aataaggctt catcgtaggc catacagaca ttacggcagc
      961 gtcggacaac aagcacatga tgatcgtggc cttgtcgcaa gcctcctcga taccgaacag
     1021 agtctcaccc ggaacccatc cgtcctcaac cgctttctcg taagtcttac cttggcgctg
     1081 accaacgatt acgttgaagc cattgtcacg aaggttcaat gactgtcccg gtccctgtac
     1141 gccatagccg ataacagcga ttgtctcatc ttttaatatc tctcttgcct tttccaacgg
     1201 aaattcctcg cgggtcatta cattctctac aacaccgcca aaattcattt gtgccatttt
     1261 ctttttaact attaatgttt aaaaacctat ttatgtatct cttttattat ctccaagtaa
     1321 ccgccgcacg acagatcgcc tttccctcat ggcaaatagc catgtcttgc ttatcgggag
     1381 cggactccgc cttatgaagc gtaagcggca taccttgttt accctcggat tggtaggcga
     1441 tctccagacg gccgatctca cgggtcttga actggtcgat atcgaacaaa tccagcaggt
     1501 gctcgatata cttcacgcta ttgaagtgac cgttgatatc caagtcgctg tatttgatcg
     1561 aatacgggat tccctccgcc ttattctccg ccggcatgat cttgcccggc ttctcgatcg
     1621 ggcacggacg ctcgtcgata tatttgccca atgcctctat atccaataag gtaggacggc
     1681 gggtctccac gtcgatagcc gcccaaatag aacgggcgaa tccaaaggtt ttcccattct
     1741 catccgccag ctcaaaacaa cggctggtga aaaggcgtcc gacctcatcg atccaagtgt
     1801 ataaattaat cttatcgaag gcggtaggat attccttcat ctcgatagcc agacgggaca
     1861 acacccaagc cgtatgacgc tccgacatat cattgaaacc gaacccacgc tctccggcat
     1921 ggctggaagc ggcgtgaatc aaatagttac caatcatagg gagcgttaca cgtcccctaa
     1981 aatccatcaa atatggctcc gccacgaaat gaaataatcc tactttctcc atatcttatt
     2041 attgttgctt ttcctgtaac tttcgctcca tatcggccaa catatcgctc aagcgctcca
     2101 ccttgctctt cgtgatagcc acacgtccgg agcggatgaa ttgcaggaca ccgatcgtct
     2161 cgctcaactc attgaacaag gcctgtgtct cgtcatagtg gccactcttc tccaatacca
     2221 cgcaggtctc gttcatctcc aagatacggg cgttgtattt acggatcaat ccctccacgg
     2281 ttcccatctt gatgaaaagc tcggtactta gcttataaag agcgatctct tgataaacca
     2341 gatcctcatc cgtattataa taagccttca agatatccac acgtttatcg atctgtttca
     2401 ccaccttatc gatcatatcc tcatcggcga atgtcgtgat cgtaaactta tggatgccct
     2461 tgatagcgga cggagagacg gacagagtct cgatgttcag ctgtcggcgt gtaaagataa
     2521 tcgttatctg gttcaaaaga cctacgatat tctctgaaaa gataataacg gtatataatt
     2581 tctttgttgt catagcttca tctcctcctt atttctcgtc tcccataatc atgtttgtca
     2641 cgcttccccc ggcaggaacc atcggatata ccattccgca agtctccacg ttagcgacca
     2701 acacgtaagc gccgtcatgg tttagcatct cagcgatagc gtcgtccaat tcctcccgct
     2761 tttcaacggc acgaccggtg ataccatagg ctttagcgat cgccacgaaa tccggattct
     2821 ccatgatggt gtttgaataa cgctcgtgga agaacaattc ttgccactga cgtaccatcc
     2881 ctaagaagtt attattaaga atgataatct tcacattcag tttctcctgc atgatagtgc
     2941 ccaattcctg aatcgtcatc tgcatacccc catcaccggt aaagaagcag accgtacggt
     3001 ccggagcccc gaacttagcg cccatagcgg ccggcagacc aaatcccatc gtacctaaac
     3061 caccggaagt caccacgcta cgggtttgtt tatatttgaa atagcggacg cccatcatct
     3121 ggttctgccc aacgtcggtt accaatacag cgtcgttacc ggtcgcctcg gaaaccttac
     3181 ggactacctc gcccattttc agttgaccct cggtcggata caattccttc tcgattacct
     3241 tatcgtattc ctctttctcg tcccgatcga actcggcatt ccattccggg cgtttacgtt
     3301 cttccaacaa cgccgtgatc atcggtatcg tgtgcttggc attccccagc acctttacgt
     3361 ccacggcaac attcttgccg atttccgagt tgtcgatatc cagatggata atcttggctt
     3421 gcttagcgta tgtctttaaa tcgccagtca cacggtcgtc gaaacgcata ccgatagcga
     3481 tcaatacatc acactcattc gttttccggt tcggccctac gtttccatgc atgccgagca
     3541 ttcccttgtt caatgggaaa tcggttggca acgcagataa gcccaatacc gtagatccgg
     3601 caggtatatc attcttttgg agaaacgctt tcaattcctc ttccgcaccg cctaacaata
     3661 ctccctgccc gaccagacag aagggtttct tcgcctcatt gattaaatcg gcggcggcct
     3721 tgatacgatc cttattgata tccggctccg gttgataact acgtacgtaa tcgaccttct
     3781 tatattcata ttccaccaac cctacttgcg cgtccttcgc taaatccagc acaactggac
     3841 ccggacggcc tgtagaagcg atataaaaag cacgagaaac agcccatgcg atctcctccg
     3901 gcttgcggat ttgataagcc catttcgtga tcggttgcgt gatgccaatc acgtcgactt
     3961 cctgaaaagc atcggttccc aacaacggcg agggtacttg accggcgatt acgaccattg
     4021 gcgtactatc catcagcgcg tcagcgatac ccgtgatggt attcgtagcg cccgggccgg
     4081 aagtaaccaa cgtcactcct accttgccag atacacgggc atatccttga gccgcatggg
     4141 tagcgccttg ctcgtggcgc accaatacat gcctcaactg gtccctataa tcatataaac
     4201 tgtcgtaaat aggtatcgcc tgtccgccgg gataaccgaa gatagtatct actccttcag
     4261 caatcaacgc tttcagcaaa gcttccgaac cggttatctt ttgtttctcc ataaaaaata
     4321 acgtgtttaa tgtatattat tggctttaat cttcaacaat ccttacacct cccttatcgg
     4381 cggagctaac catcttcccg tacgctctca acgctttcga gacctcacgc tgacgcgtcg
     4441 gcggcgtaaa ggctttcttt ccacgtgcct cttccgcctc acggcgctcg gccaactcct
     4501 cgtcgctcag ccgcacgttg atggaacgtt ccgggatatt gatctcgatg atatccccgt
     4561 ctctcaccag tccgatagcg ccaccggaag cggcctcggg agagatatgc ccgatagaaa
     4621 gaccggacgt accgccactg aaacgaccat ccgtgatcaa ggcgcactcc ttacctaagt
     4681 gacggctctt tatataagag gtaggatata acatctcttg cattcccggc ccccctttcg
     4741 gaccctcata cgtgatgacg accacatcgc ctgaaacgac cttgcctcct aaaatgccct
     4801 cgcaagcggc atcctgtgaa tcgaagactt tcgccgggcc ggagaatttc caaatactct
     4861 catccacacc ggcggttttt acgacacatc cgtccaaggc gatattccct ctcaaaacag
     4921 ccaagccgcc atccttggaa taagcgtgct ccacatcgcg gatacaacct tcggcacgat
     4981 ccgtatctaa ttccttataa taagattctt gggaacccat ctggatactg aaccgatgag
     5041 cgggagcgct cttgtattta cggatcgcct cctccgttac gttcggggaa gtgacggcgt
     5101 atttatcaac agcctcggcc aaggtcaggc cgtccgcacg tctcgtgctg ccatccacaa
     5161 gcccggcttt catcaactcg ttcatgatac cgaggattcc accggcacgg tttacgtctt
     5221 gtacatgata agtgtgcgta ttcggggcta ccttacacag gcaaggagtc ttgcgggata
     5281 acatatcgat atcctccata tgaaaatcgg cgccggcttc ttgtgccacg gccaataagt
     5341 gaagcactgt attggtagac ccccccatgg cgatatccag cgacatggcg ttcaagaaag
     5401 cctgacgggt agcgatgttg cgaggtaaca cggaatcatc cccgtcacga tagtatttgt
     5461 aagcgttctc aacgatttgc ttagccgcat cacggaaaag ttggatacgg ttcttatggg
     5521 tagccacgat cgtcccgtta cccggaagcg ccagaccgat cgcctcgttc aagcagttca
     5581 tagagttagc ggtaaacata ccggaacaac aaccgcaacc cggacacgca tggcgttcca
     5641 cctgctcgat acgctcatcg cttaccgatg tatcggcaga ctcaatcatc gcgtcgatca
     5701 aatcaagatg gcggccatcc agctcacctg cctccatcgg gccaccggac acgaacaccg
     5761 tcgggatatt taatcgcatg gaagccataa gcatacccgg cgtgatctta tcgcaattgc
     5821 tgatgcaaac catagcgtcc gccttatggg catttaccat atattccacg ctgtccgcga
     5881 taatgtcgcg tgaaggaagc gagtaaagca tcccatcgtg ccccatagcg ataccgtcgt
     5941 cgatagcgat cgtattaaat tcagcggcga aacaaccttg tttctcgatc tcggccttga
     6001 ccaattgccc gatctcatgc aaatgcgtat gccccggcac gaactgggta aatgaattta
     6061 cgatagcgat aataggcttg ccgaactgtt cctctttcat cccgttggca cgccatagcg
     6121 cacgggctcc ggccatccta cgaccttcgg tgctaaatga gcttcttaac ggattcttca
     6181 tctctttcct attttttgtt cgtagagcgc tttatccacg cctctacctt gaattattta
     6241 taataaaaaa gcctttccct atatggagaa aggcttaaga aatatctcta cgacttcaca
     6301 acttcttaca cacctttctc cttacctact aatgactaga aggaccacca cgagaataat
     6361 atgcaatacg ttgttcatca tcttttctta ttgtctttgt ttgtttgacg ctgcaaatgt
     6421 agaacaataa ttgatatgcg caaaggattt aaaagaaaat tcttcatttt tctttcaatt
     6481 ctcaagcaaa taccatttta ggattgcatt ttaacaggag caagagtgta ttacttagga
     6541 atcggaaggt atagaaggga aaaaacttcg atttccaaac agaaacagta aaaagacaaa
     6601 tgttatctaa aacagattcc agataacatt tttatcagat aacacgactt acgataacac
     6661 gtatctcata agaaaatcct attctagcga taaaaaagat acatataaac tctaaatcac
     6721 atatttatta acacttgtag actataaata gccttgaaaa aattcataat agtgttctag
     6781 aaaaaacata aggaagtttt ctgaagaaca taaggaagaa atttcatcta gtatcggact
     6841 aaattttgtt aacattcgaa taaaaatcac ctaaaatcaa gactaaatcc ggcataaccc
     6901 acgctagaag cagctcaagc aaagacattt tcaaaatgac tttcagacag agaaagcctt
     6961 aaatactcaa ccgatagaca gctattcaaa catcaatcat aaaaaagacc aacaacacct
     7021 gcattcaaac atcattctga tttacacaac catcaaatgc ttgtgttttt tccgtgcgac
     7081 caagcccccg ccccataatt catcacccac agagagcaat aataacactt tgacatttcg
     7141 tcaacaaggt tcacatagaa aagtctatcc ccaccaaatt tcataaaaaa gccccaatag
     7201 cgaaacagga aatttatata gttccaagct agttcttaaa taaaatttgc cctcctcaag
     7261 aaaattagct aatatcgcga ctattcataa agttgttgat ggattaatcc atgggagaga
     7321 ggaacaagca tattgagaac cttagaaagg gtaatcgttc atcttttgaa tatctttaca
     7381 cggtttggag tggcaaatta tataattttg tcatgaaaat ttctcatggg gattcctact
     7441 tggcagagga aatggtacaa actgtatttc ttaaagtatg gaaaaatcga gaacaattag
     7501 acccaaaact gtcttttgga gcctatttat gtacgatagc aaaaaactta ttaactaacc
     7561 attaccaaca taaaatgatg gagattctct atatagaaca acaaatcgac caccccggaa
     7621 ctccttatgc cagaggtacg gacgagatcg tagaatatca tctcctagaa gaattcgttg
     7681 attctttaat acaacaaatg cccgaaggaa ggcaaagaat ttataaacta agcagacaat
     7741 cccacctatc caaccgggag atagcagacc aattgcagat atcagagaat accgtggaat
     7801 cccaactgac caaagccatc tcctttctac gcaaaaggtt aaaagaccaa tacgacctag
     7861 gacttttagc tttaagttgc ctccttaata gttaatgaat actaaatcca caggatgcga
     7921 taacggaaac ttccctgtca tttgtatact gaataaagac agaggaaaat ggaaagaaac
     7981 gattacatac atatatttaa caagttccta gagaataagg caactccatc ggaaataaag
     8041 ctattgatag aatggctaaa agaacgaaaa gcttttgaca catgggctga tgatatatgg
     8101 atgcaatccc cgatggaaat ggatccttca gtaaaacaac atttactaga cgaactccgt
     8161 aaacaaatct tttttaaaga aacagggaaa aggacattca tgagtctttc tctcccttca
     8221 cttttccatt atgcgctacg tatcacagca attatcctat tgctcataac aacaagtatt
     8281 gtcacctatc attatgcaat ggataaacag cgagaaccga tggacatgat tgtcgctgtc
     8341 gagaaaggac aaaaagcgaa tataacattg cctgatggtt caaaaggatg gataaattca
     8401 gattcaaagt tatcttatgg aagccgtttt aatgcagatg aacgggttct gaatctagaa
     8461 ggcgaagctt attttgaagt caagcccgat gctaaacgtc cttttatcgt tcaatcggga
     8521 aaggtatccg taaaagcttt aggaaccagt tttaacgtaa agaactataa cacggaagag
     8581 cacatatccg ttgtattaat gaccgggaaa gtagaagtaa ccgcaaacga taaccatgta
     8641 gacctgttgc ctaatgaaca agctattttc aataaacact ctagcatact ggggaaaaac
     8701 agggttgaca atagtttaga ttactccagt tggatgtaca atacattgaa ttttgagtca
     8761 acgccattca gcgagattgc tcatacgctg gaacgttatt acaataccca gatcgtattt
     8821 aaatctgagg ccttaaagag ttatcgtttt acaggtaagc ccgggaatac cagtctagcg
     8881 agcatcttac atttattatc tcttacctca ccattagcct acgagataaa agacagtgtg
     8941 gttattttgt atgagaacaa cgacaaaaaa gagttatata acagagtatt aaaacagtaa
     9001 atagcaattt catgaaaagc ccgtaaaaaa tcggggtaga aatgctaggc atttcccccc
     9061 gaaaaagaaa tcagttaacc gcgcttaggt atctcgcaaa tagcaagcgc aagtactaat
     9121 atccatagaa tacaaaagta tgaaaaaaaa cttgtccgtg tatcacaata cataaaaata
     9181 cggtcaatca aaacagtcgg tctggcacta ttcagtagtt taatcttggc tccttcactt
     9241 tatgcccaaa tttcactgga tgtacaagac caatccatcc gtcacatatt aaaagagata
     9301 gaaaaggcgg gggaatacaa attcttctat aacagtgatc taagtaacct agatcacaaa
     9361 acgtcaatat ccgtacagga taaaaacatt gatgaagtca tgagcctctt attagccaat
     9421 acggaaatat cctataaaaa agaggccaat aatatgattg tattaacaat taaatcatct
     9481 tcttcaccgc aagctccgag aaagacaaga aaaataacag gaacagttgt agaccctgac
     9541 ggtttaccaa tcatcggagc aaatgtaatt gagcagggta caacaaacgg ttccattacg
     9601 gatttggatg gaaaatttga attaataatt accgaaaatg ccatcttaaa tatctcttat
     9661 atcggttttt ccgacaaaca aataacagtc aaggaagaaa cctccttaca ggttacaatg
     9721 acggaagaca cccagaagtt agatgagata gtagttgttg gatacggtgt acagaaaaag
     9781 gtaaacctta ctggatctgt ttctgccgta aaaggcgaag aactcagcca acgcccagta
     9841 gctaacgcaa ctcaaagttt acaaggatta gtacccggat taaccgtatc caactccaac
     9901 tcaggtcgcc cgggagctag tggagccttg agtttacgag gacaaggaaa tttagcgaac
     9961 acagcgaatc cttatgtatt agtagacggt gtagaaatgg atttggcaga tgtaaacccc
    10021 aatgatattg aatcgatttc cgtcttaaaa gatgctgctt ccgccgctat ttatggcgcc
    10081 cgtgccgctt atggtgtaat tttagttacg acgaaaaaag gtgaagaagg taagatgcgc
    10141 atcagttatc aaggtaccgt aggatggagt tcccctactg taatgccgga aatggctaat
    10201 gcttatgact atgcgacttt tttcaatcaa gcttgtacca atgctaacgt aatcaagcaa
    10261 tataacccgg aaaaattaca gcaacttcag cagtacatga aagatcctgc tagcgtaaat
    10321 ccttgggcag agcttaatgg agaaaataat ctagtaggag cattcgaaaa cacaccaaag
    10381 ggtttgggca atgtggatta ctttgattta cattataaga actccgcatt caaacaaaac
    10441 cataatttga gtctcagtgg aggtggcaaa aaagcgcaat attatatctc taccggaatg
    10501 tatacggaag atggtatttt aagatatgcg gacataaaat ataaacgctt aaatttcaat
    10561 gcaaatatcg cctctcaaat tacggactgg ctaaatttga aagttaatac taaattcatg
    10621 aactcggata atgacacacc ttttggtaaa ggggccttat ctgaaggctt ttatcattca
    10681 ttagctcgct tccgtcctac cataagccca atcgatccta atggtcattt tacggagctt
    10741 acaatgattc cctatttaca aagtggcacg tatacaaata cacagaaaaa taatctgaca
    10801 ctgactggtg gtctcgaagc acaaccaatc aagaactgga gaatattctt cgactatacg
    10861 taccggcaaa ataatgagaa ttatgaggcg ctcaacgtag ccccgatgat cccgggagcg
    10921 gataacgaga ccttatacaa agggacaagg caagaattag gcgtgatgga gaatgggcaa
    10981 ttcacccgtt catccgcctt aagccaatat caatcaatta atctatactc aaactatatg
    11041 ttctctttgg ccgataaaca taatttcacc gttatggctg gttaccaaga agaaaattac
    11101 gcatatagct atttatatga gtctgtaacc gacatgatct ccaccaataa tccaggcctc
    11161 aatcttggca caggagaaaa atccacgaca gatactcgaa acggatgggc tacccgagga
    11221 tttttcggac gtattaacta tgattatgac ggacgctatt tattagaagt gaatggacgc
    11281 tacgatggtt cttctcgttt tgcctcagat catagatggg gatttttccc ttcggtctct
    11341 ttaggatgga atattacacg tgagtctttc atggaaaaat ctttagaggt attatctaat
    11401 ctaaagttac gagcctcttg gggactatta gggaatcaaa gcggagccgg actttatact
    11461 tttacctcaa tcatgggaat ccagccgtta ggtaattggt attttcaaga tggaagagat
    11521 atgtacataa acgcccctgg agttattgat ccttttacaa cttgggaaaa agtggaaagt
    11581 aagaatcttg gccttgactt cgggttcttt aacaacgctc tgaccggcac cttcgatgta
    11641 ttccagcggg atacaaaaga tatgttagga ccaagtgccg accttgcaga tttctttgga
    11701 gcagaggctc ccaatacgaa taacgcaagg atgagaaacc ggggatggga acttagcctg
    11761 caataccgag gaaaaatcgg gaaggatatt cattattcaa taggaggctc tttagctgac
    11821 gcgacatccg aagttacagc ttatgaaaat ccgacaggga ccaatcctca agataattgg
    11881 tatgtaggga agaaagtcgg tgagatttgg ggatacaaag cctctgggct actccagacc
    11941 caagaagaag ctgacacata taataacaca tacgatttat ctttcttatc cggtcaaaaa
    12001 tggatgccgg gagatgttaa atatatggat ttaaataacg acaaaaagat caacaatgga
    12061 aataacacat tggaagatat gggtgatatg tgtgttatcg ggaatacgac tcctcgatat
    12121 caatatacgc ttaatggttc catttcatgg aaaggaattt cccttagcat gatgttccaa
    12181 ggcataggaa aacgaaattg gtctccagat ctaggaaccg tttacttttg gggatcggga
    12241 gcttatgcac aagtcacggt attcaacgat catctagatt attggactcc agagaatcca
    12301 gacgcctatt atcccaatcc ttatacagga gcagcaggaa gtatcaatca gtttcgaaat
    12361 aagacctcac aaaaaagtga cagatacatg caaagtgccg cttattgccg tttgaaaaat
    12421 ctgacaatta gttatgatct gcctaattca tggagccaga aaattgggtt gagcaaagca
    12481 caagtgtttt tctctggaga gaatcttcta acatttacca agcttccttc catgtttgac
    12541 ccggaagcta tttttacagg taatgactat accagtgagg ccggaaagaa ttatccaatg
    12601 aataaagtgt tatctatcgg agttattgtt aatctataaa gcgtaattta tttatgaaaa
    12661 gaatatatct atcaatggtt tccctatgtc tattagggct atgtagctgt ttcgacatgg
    12721 ataaatatcc ggaaggagaa ttgtcttctg tcaattcttt caccagtaca acagaaatca
    12781 ccaagtatct gaatcagttt tatgaatcaa ctcttaaaat taatgacaaa gatgtggcaa
    12841 actctgccat aaaggtacaa tctaacagca ttggaaatcc aacgggtatc gcctttggag
    12901 acttgaatag cgataatatg cagagtaatg taatagacac acgtcttgcg ggagaaacca
    12961 cattaagttc cgctgtcgaa ttaacagagt ataaacatat cagaagtcta aacttcttaa
    13021 tcaacaacct cgataattgc gaggagatcg gtccggaaat ggagcaatgc atcggagaag
    13081 cttatttctt cagagcctgc tattattata ggttattcgt taattatgga gaagtcactt
    13141 ggttaacgaa agtattagat ccgattcaag aacagatgga acgtccccga aacagtaggc
    13201 ttgaggtcgc tgatagtata ttggcggatt tagatatagc gatcgagcat ctaaacactc
    13261 aaaccaatag ctcgacaatg cgtgtacaca aagatgtagc aagagcgctt aagagtgagg
    13321 tcgctttatt tgaaggtact tgggagaaat accatcgtgc gaaaaacacg ccattctatg
    13381 ataaaaaagt aactgatgag aaaatcagct cttatctacg gcaagccgca gatgccgcta
    13441 aagatgtaat agacgaaggg gtatggagca tctcaaaagg ggatcccaat accgcttatc
    13501 gagacttgtt catcactttg gatctctcac ataatccaga agttttatgg tggaagaaat
    13561 atgatgccgc caataacatc ggccattccg taacacgtta tttaaataaa ggaggtggca
    13621 cttgtggggc atccgcttct cttgttgatg attatttaac aaaagaagga aaaccttttg
    13681 tcggttccga acgagacaaa gcaaaggtaa tgtacgggga cgaattgagt ccggacttac
    13741 gagacccacg attatcccag accatttgca tgccaggaca agatttacgt ccaaatggag
    13801 aattcgtatt caaacttcct cctttgaatg aggaaagccg gaatcaaaat acgacaggtt
    13861 attctatcct aaaatacgta gaatataata cgacttatat tcctactata gatggggaag
    13921 gcaaaagcca agcgccagct atacaattcc gttacgccga tattttatta aactacgctg
    13981 aggctctggc agaattagat ggcgcggcta acgctagcaa aataaaagaa gccttaaggc
    14041 cacttcgaga gcgtgtgggc atgcccgaga tggatttcga cagagagttc aataccgatc
    14101 ccgattatcc gtttaataaa ttggataaat atatacaagc agtacgaaga gaacgacgca
    14161 tagaaaaagc tttagaggga agccggcttc aagatatctt gcgctgggcc gccgcagaca
    14221 tcctcattat tggaaaaact ccaacaggtg cattattcaa agggagctct ttggaaaccg
    14281 cttatggaga aagcctgcaa gaaggtgaaa atcttttctt aacaggtacg ccctccgact
    14341 ccaaacgcta tatcataccg ttcaataata agcattatcc taacggatgg caattcaatc
    14401 cggaacgaga ttatttattg cccatacaac ctcgtatgct atcgcttaca ggtaaccaat
    14461 gggtccaaaa ccccggttgg taatttactt gattacagga tttagcctaa taaaagagaa
    14521 agtctttcct cacaaatttt aggctaaaac cctgtaacaa acaaatacct taatcacgaa
    14581 cacaagaaaa gtctaaataa tgaaaaaaga attattattc acattctctg ctttaatagc
    14641 tacgacttcc tgcaacatca aaaaaacaga ttcagagcag atagcaggaa aaaagccgat
    14701 gaatatcatc tatatcatgt ctgacgatca ttcttaccag acaatcagtg cttatgataa
    14761 acgcttcata caaactccca atatagaccg actggcaaac gagggagtac gtttcaccaa
    14821 tagctttgtt gccaattcca tcagtggacc tagtcgagcc tgtatattaa ccggtaaaca
    14881 tagtcatgct aatggtttca ctgataacag ttccacattt gatggttccc agcaaacata
    14941 ccccaaactt ttacaaaaag ccggatatga aacagcaata atcggaaagt ggcatctaac
    15001 ttccgctcct accggatttg attattcgga aattttaata ggtcaaggca tttattacaa
    15061 cgctccattt atcaaaaacg ggaaacaggt cccatcaaaa ggctatgtta ccaacgtcat
    15121 cacagaaaaa gcaatcgact ggatggagaa tatacatgat aaaaataagc ctttctgctt
    15181 gttactccat cacaaagctc ctcatcgtac atggatgccc gatacttgtg atttacaact
    15241 tttcagcgat acgacattcg agttaccagc caatttttat gacgattaca acggtcgtca
    15301 agccgctcat gagcaaaaga tgagtatcat aaaagatatg gatttagtct atgatttaaa
    15361 aatggctgat aaagaaaatg aaatccatac aactacaggg ttagagaatg ccggacgcag
    15421 catgtataac agtatgacac ccgaagagaa agcagcttgg gatgctcatt atgatccaat
    15481 cattcagaaa ttcaagaaag acaaactttc tagtaagcaa ctatctgaat ggaaatatca
    15541 acaatatatg cgagactatt tacgtgtcat ccattccata gacagaaata ttggagtatt
    15601 attgaattat ttagaaaaga caggattatt agagaacaca atgattgtct acacttccga
    15661 ccaaggattc tatatgggag aacacggatg gttcgataaa cgtttcatgt atgaggaatc
    15721 tttccggact cctttattaa ttcgtttgcc aggaggaaag aaaggagata tcgatgagtt
    15781 tgtccaaaac attgattacg gaccgaccat cctagattta gcaggaatcc aaatcccatc
    15841 cgatatgcat ggtatttcct ttttgccttt gttacgtgga gaaaaagttg agaactggcg
    15901 taaatcactc tattaccact tttatgagta ccctgcggag cattctgtta aacgtcatta
    15961 tggcgtacgc acagaacgtt ataaattaat tcatttttat aacaatatcg ataaatggga
    16021 attatttgat ctacaagaag atcctatgga gatgaacaac ttgtatggaa aaacaggata
    16081 tgagaatatc actcatcaac tggaaaagga gcttatacgt ttacaaaaac aatatc
//
