LOCUS       gnlProkkaOHCKOHPG_27   12852 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OHCKOHPG_27.
ACCESSION   gnlProkkaOHCKOHPG_27
VERSION     gnlProkkaOHCKOHPG_27
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 07:24:54
            Original ID  :: gnl|Prokka|OHCKOHPG_27
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12852
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12852
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2651:2852]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2652..2852
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12852
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12852
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             82..540
                     /locus_tag="ctg27_1"
                     /transl_table=11
                     /translation="MIDAFLATVPEEHSQHTELDYAVDYTAYLMQEEPGVDAEDEPEVP
                     KLRGHELIDDFIQKSESSDAPDTRREFLVEKEEETEEEEEPSVSPVTEELDDSCFTETL
                     AKIYIKQHRYDKALEIIKKLSLNYPKKNAYFADQIRFLEKLIINAKSK"
     CDS             569..934
                     /locus_tag="ctg27_2"
                     /transl_table=11
                     /translation="MLIASVLMCFIVLIQNSKGGGLASGFSSSNQIMGVRKTTDFLEKA
                     TWTLAAVMVVFSIVSAYTIPSSTGKGGDVILEQAQQEEKTNPYNMPVGTEAPQSEAPAA
                     TTPAEAPAPAAEAPAAE"
     CDS             1088..2479
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 100.6; E-value: 1.2e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg27_3"
                     /transl_table=11
                     /translation="MTEQLKLKLNDSKATRWGALVIVAFTMMAAYYVNDVVAPLKTMLE
                     TDLAWSSTDFGFFTGGYSFLNVFFLMLIWGGLILDRFGIRFTGKLATILMVGGTALEYY
                     AMTGLAGADATLFGINEIFGYKTGVFVAFAGYSIFGVGAEVAGITVSKIIAKWFKGKEL
                     ATAMGVQVALARIGSQAGYAVAIPLARAFGISTPVLLGLVLLLGGMIAFFIFAVMDKKL
                     DKQMEAAAIAAGTEDEEEKFSFKDVKNILVNPGFWLIALLCVLFYSCVFPFQKFASELM
                     IIKYGINENVAGTFAGLPALGALILTPVFGGFIDKRGKSASIMLLGSAMLICVHFIYAI
                     PDINYWLVAIVLMIILGIAFSLVPSAMWPAVAKIFPVSQLGTAYALIFFIQNIGLWGIP
                     TLIGWVLDAYCISGKKPDGTNMYDYTVPMCIFTGIACLSLIVALLLKKADKKYGYKLEE
                     PNIQK"
     CDS             2652..2852
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_4"
                     /sec_met_domain="PqqD_RRE (E-value: 2e-10, bitscore: 31.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.9e-17, bitscore: 54.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPDIHVRLEEHGTAVWNLIDGHRTVREIISLLARHFGEEENYIP
                     RVTAYVMQLRKDGFIQLTIRN"
     CDS             complement(2860..3063)
                     /locus_tag="ctg27_5"
                     /transl_table=11
                     /translation="MDGVAYNLPGKAQVTLVYNNKKLFDDQLPITQFGTVEYLAPVLFN
                     KNSTIKVLFDTATGGLIKVDRE"
     CDS             complement(3216..3824)
                     /locus_tag="ctg27_6"
                     /transl_table=11
                     /translation="MRGKDYGVTYMLPKTEIEIVLQATKHTYTPGEFCRYADRYLRLNN
                     VSAESEEFWTLDKIETRIAGVPDKDNIYFVKMKDKTVAPLMELTEDGIVRSINIPFSDK
                     PAAKTPEAKATESSIDPRSFLTEEILMSNSSAKMAELVAKEIYSIRESKNALLRGEADN
                     MPKDGAQLKLMLDNLNQQETAMTEMFSGKIKKARHSPSG"
     CDS             complement(3976..5103)
                     /locus_tag="ctg27_7"
                     /transl_table=11
                     /translation="MKTLLFCMLGLGLTACGSSPKGTNGGQDELAMLIGTYTNGSSKGI
                     YTFRFNQETGTAVPLSSAALPNPSYLVPSEDGEFVYAVSEMNDSTAALSSLAFDRETGE
                     LRLLNTVPTFGADPCYVATNGREVLTANYSGGTMSVFPLQKDGTLAPADTLFQGSATGP
                     DAIRQATPHIHCTVFSPDGKYIFATDFSADRILRFVMHPDNPIPHASLEAVDIEADSGP
                     RHLTFSPNGKFAYLITELSGKVIAFSYDDGRLEQIQTITADTVAARGSADIHLSPDGKY
                     LYASNRLKKDGIAIFAVNPENGTLTKVGYQPTGIHPRNFNITPNGKYLLAACRDSNVIQ
                     VYKRNEVTGLLEDTHQDIVVDMPVCVQFVSSVNNL"
     CDS             complement(5205..8177)
                     /locus_tag="ctg27_8"
                     /transl_table=11
                     /translation="MEDIFSKRKTLRTIKADTSDYFIPLFHTLAVFLSTKETIITKRFL
                     EHIMKNLIALTLLLGGSTLLCAQKPAKTPATYKPVKSEMYRKGWIDFNKNGVKDVYEDP
                     SAPLEARIENLLQQMTLDEKTCQMVTLYGYKRVLKDDLPTPEWKELLWKDGIGAIDEHL
                     NGFQQWGLPPSDNAYVWPASRHAWALNEVQRFFVEDTRLGIPVDFTNEGIRGVESYRAT
                     NFPTQLGLGHTWNRELIRQVGLITGREARMLGYTNVYAPILDVGRDQRWGRYEEVYGES
                     PYLVAELGIEMVRGLQHNHQVAATGKHFAAYSNNKGAREGMARVDPQMSPREVENIHIY
                     PFKRVIREAGMLGVMSSYNDYDGIPVQGSYYWLTTRLRGEMGFRGYVVSDSDAVEYLYT
                     KHGTVKDMKEAVRQSVEAGLNVRCTFRSPDSFVLPLRELVKEGGLSEEVINDRVRDILR
                     VKFLIGLFDAPYQTDLAGADREVEKEENEAIALQASHESVVLLKNADELLPLDINSTKK
                     IAVCGPNANEEGYALTHYGPLAVEVTTVLEGIQEKTKGKAEVLYTKGCDLVDAHWPESE
                     IIDYPLTDDEQAEIDKAVENARQADVAVVVLGGGQRTCGENKSRTSLDLPGRQLQLLQA
                     IQATGKPVVLILINGRPLSINWADKFVPAILEAWYPGSKGGTALADILFGDYNPGGKLT
                     VTFPKTVGQIPFNFPCKPSSQIDGGKNPGPTGNMSRINGALYPFGYGLSYTTFEYSDLD
                     ITPRVITPNESATVRLKVTNTGKRAGDEVVQLYIRDVLSSITTYEKNLAGFQRIHLEPG
                     EAQELSFTIDRKHLELLDADMKWVVEPGDFVLMTGASSEDIRLNGTLTVEDYQTRAKAI
                     EAQKPAKRVSASTNPEDAENVLDEKINTAWQGNKGDYITFALKNGAKVDKVAIAFTRDN
                     NLPATFEIQLSGGGGQFLTVYSGTVSEYGKLISYPFKGTTASDLRIVLNDDRVSIAEVK
                     F"
     CDS             8463..8621
                     /locus_tag="ctg27_9"
                     /transl_table=11
                     /translation="MQISITEDRYSLLQGVIPSTDTGFGSCLNIDDNGVHIFYVWKIIV
                     FITKSQY"
     CDS             9391..9876
                     /locus_tag="ctg27_10"
                     /transl_table=11
                     /translation="MKIHEGKCTEKILKERERIGSRLAILRKKRNMTQEELANLCGVNR
                     VNIAKIEKGAYNVSIDILSKVTSALGFVIDIKVDSSVCPTHFSQRKPVKLVIGKDYYVS
                     FGNNEAHRCKLVDIPEMYQGQRIKIETPTPRGSITHILFADEIGTTPDEAVMNQVTM"
     CDS             complement(10076..10906)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 59.4; E-value:
                     6.4e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_11"
                     /transl_table=11
                     /translation="MDNQTQEGTKNMQKRHTDRESYFDEQSQTSKNYYIPYIKEVIGHI
                     PDKVLEVGCGEGGNLLPFAKAGCRVMGVDIDAMRIEQARAFFAQRHQQGQFIATDIFQL
                     EDKATNFPLILLHDVIEHIRDKERFLSGLQKHLSADGAVFVGFPAWQMPFGGHQQIAHS
                     HIVSHFPFLHLLPRTLYRWILRLCGEQERVITELLDIKSTGCTIELFNRIARQANYQII
                     DRRLYLINPHYKIKFGLSPRRLNGVIAAIPYIRNFFCTSCFYILKKGTKTVNHY"
     CDS             complement(10955..12595)
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 69.4;
                     E-value: 4.9e-21)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg27_12"
                     /transl_table=11
                     /translation="MDTKALVTLCQKGNGQALSLLYENYSEKMLKVCLRYIPDPTIAQD
                     LLHDGFVIIFTSIHSLRNPEKLEYWMKKIMRNLALQYLNHANANPTIPLTDIPEEEEPA
                     ENPFCPDFISYDKMLDIVESLPEGYCKVFKLAVLEGLSHKEIGDLLGIAPHSSSSQLFR
                     AKILLKKMLAGYRVFIVLTVLLLFPTLYDYLYREKKSIRENRLSKVSSRQAGSTQQTKK
                     TDTPRTDEQCHTKENLNKRERIIPPVPVSTEWPLAIPTMKDSIHKYPIPSPFTGQTITN
                     RQMAFVFSPSLMPPTRKKKSGKWKLMLAGSLGPQLTQNLYKLIATPHTDGISSDFPQQV
                     STWEEYYSYLHTRYQQGTLGKDSIGLMQIAQNNSGRIVENQQHHAPIVVGLSLSKKLNE
                     RWSLETGLQYTLLRSEFTTGEAFRIQDNQKLHYIGIPLRLSYRFWHYKRFSGYATAGIQ
                     VDIPIKGTLQSFHVTDSIPHKLDSQPVSAPWQWSVNTSIGIQYRLTPQAGIYLEPTVNY
                     YIPDGSQLRTIRKEHPFTFTLPVGLRISW"
ORIGIN
        1 agaaggatag ggtcctagac aaaggtcttc agcagtatag gggagagaga gagaaggaga
       61 gagagggacc gtaccctttc cttgattgac gcatttctgg ctactgttcc cgaagagcat
      121 tcacagcata cggagctgga ttatgcggtg gattatacgg cctatttaat gcaggaagaa
      181 cccggtgtgg atgcagaaga tgagccggaa gtgcctaaac tgcgcgggca tgaattgata
      241 gatgacttta tccaaaagag tgagtcttcg gatgccccgg atacgagaag ggagtttctt
      301 gtagagaagg aggaagagac tgaagaagag gaagagccct ccgtatcgcc ggtaacggaa
      361 gagttggacg atagctgttt tacggaaact ttagctaaaa tctatataaa acagcaccga
      421 tatgataagg cacttgaaat tattaaaaaa ttaagtttga attatccaaa aaaaaatgct
      481 tactttgcag accaaatcag atttttggag aaattgatta ttaacgctaa atcaaaataa
      541 caaaatgtat ttattattag ttatcttaat gttgattgca tctgtgctga tgtgcttcat
      601 tgtattgatt caaaattcta aaggaggcgg tctggcatca ggcttttcat catccaacca
      661 aattatgggt gtgcgcaaga ctacggactt tttggaaaaa gcaacctgga ctctggcagc
      721 tgttatggta gtcttcagta ttgtttctgc ttacactatt ccttcttcca caggcaaggg
      781 cggtgatgtg attctggaac aggcgcaaca agaagaaaaa actaatcctt ataacatgcc
      841 cgtaggtaca gaagctccgc aatcggaggc ccctgcagct acaactccgg ctgaagctcc
      901 tgctcctgca gcagaagccc ctgcagcaga ataagataag gatattgcgg atgactcccg
      961 cttggaaaaa taagagaaag gttgatactg aaaaggtgtc agcctttttt cgttttgatg
     1021 aagtatttat ttacctttgt cagcaattta tgcaatctga ttaataaatt gaaatccaaa
     1081 tagtacaatg acagaacaac tcaaacttaa attgaatgat tccaaggcta cccgttgggg
     1141 ggcattggtg attgttgcct tcacgatgat ggcagcttat tatgtaaacg acgtggtagc
     1201 accgttgaag acaatgttgg aaacggactt ggcttggtcg agtaccgatt tcggattctt
     1261 taccggtggt tatagttttc tgaatgtttt tttcctgatg ttgatttggg gaggattaat
     1321 cctcgaccgc tttggtatcc gtttcaccgg aaagctggca actatcctga tggtaggtgg
     1381 tacagcactt gaatactatg caatgacggg acttgccggt gccgacgcga ctttattcgg
     1441 aatcaatgaa atatttggct ataaaacggg tgtgtttgtt gcttttgccg gttattccat
     1501 ttttggagta ggagcggagg tcgccggtat tacagtttcc aaaatcatag ccaagtggtt
     1561 taaggggaaa gagcttgcca cggctatggg ggtacaagtc gctttagcac gtatcggttc
     1621 gcaagccggt tatgccgtag ccattccttt ggcccgtgct ttcggtattt ccacaccggt
     1681 gttgttgggt ttggttctgt tgttgggcgg tatgattgct ttcttcatct ttgcagtgat
     1741 ggacaagaag ctggacaaac agatggaagc tgctgccatt gctgccggta cggaagatga
     1801 ggaagagaag ttctctttta aggatgtgaa gaatattctg gtcaatcccg gtttctggct
     1861 gatagcattg ctgtgtgtat tgttctactc ttgtgtattc ccattccaga agtttgcttc
     1921 cgagttgatg attatcaaat acggtatcaa tgagaatgtg gccggtacat ttgccggact
     1981 tccggcattg ggagcgctga ttctgactcc ggtctttggc ggtttcattg acaagcgggg
     2041 caagtccgca tctatcatgc tgctgggctc ggccatgctg atatgtgtgc atttcattta
     2101 tgctattccc gatataaact attggctggt agctattgtg ctgatgataa ttttgggtat
     2161 cgctttctcg ctggtacctt ctgccatgtg gccggctgtg gccaagatat tcccggtaag
     2221 ccagttgggt acggcatacg cattgatttt ctttatccag aatatcggtc tttggggtat
     2281 tcctacattg atagggtggg tgcttgatgc ctattgtata tccggcaaga aaccagatgg
     2341 aacgaatatg tatgactata cggtgcctat gtgcattttt accggtattg cctgcttgtc
     2401 ccttatagtg gccctactgc tgaagaaggc agacaagaag tatggttata agctggaaga
     2461 gcctaatatt cagaaataat aggaaaagcg gataccatat gatggaaata cccgaaggaa
     2521 aagtaagtct gttggacgct gttccggtcc gctgtggaca tataacaacc gaatgggaag
     2581 gtgagtgcgc cgtactcgcc tacccacggt ttaaatacga atggatgcgt cgttttttat
     2641 tgccgaaggg gatgtctcct gacatccatg tgaggctgga agaacacggc acagctgtct
     2701 ggaatctgat agatggacat cgtaccgtgc gtgaaatcat ctctctgctt gccaggcact
     2761 ttggggagga agagaattat attccccggg tcaccgccta cgtaatgcag ttgcgtaagg
     2821 atggatttat ccagttgaca atccggaatt agaattcctt tattccctat ccacttttat
     2881 caatcctccc gttgccgtat caaacagcac tttgatggta gaattcttgt tgaacagtac
     2941 cggtgcgagg tattctacgg tgccgaattg ggtaatggga agttggtcat caaacaattt
     3001 cttattgtta tacaccaatg tcacttgtgc cttgcccgga aggttatagg ctacaccgtc
     3061 cactttcttt ttgccttcct cggtggcaga tacatcggga cttttgaggt cggtgacgct
     3121 gatataatac ggttcaccgg caaggtcatt attggccacc actcccagct ttcgggaaaa
     3181 acggaaagcc acttcatctt tcatctcttt aggcgtcagc cggatggtga atgtcttgct
     3241 ttctttattt tgcccgagaa catttccgtc atagccgttt cctgctggtt cagattgtca
     3301 agcatcagct tgagttgggc gccgtccttg ggcatattgt ctgcttcgcc gcgcaggagg
     3361 gcattcttgc tttcgcggat gctgtatatt tccttggcca ccagctcggc catcttggca
     3421 ctggaattgg acatcagtat ttcttccgtc agaaaactgc gtgggtcaat gctgctttcg
     3481 gtggctttgg cttcgggcgt cttggcagca ggcttgtcgc tgaacggaat gttgatggag
     3541 cggacaattc cgtcttcggt aagctccata aggggtgcta cggtcttgtc tttcatcttc
     3601 acgaaataga tgttgtcctt atccggtaca ccggctatgc gggtttctat cttatccagt
     3661 gtccagaact cctcggattc ggcagacacg ttgttgagac gcagatagcg gtcggcatat
     3721 ctgcaaaatt ctccaggagt gtaggtatgc ttggtggctt gcaatacgat ttctatttct
     3781 gttttgggca acatataggt cactccgtag tctttgccac gcatcacacc ggtggttacg
     3841 tctgtttgcg ccagggcagt ggtagacaag aacagagctg agagcatcaa tatattcttc
     3901 ttcataatgt acattcgttt agactgattt agctaaggga caaagttaat gaagttatct
     3961 ttgctaaata ttgctttata aattattaac agagctgacg aactgtacgc aaaccggcat
     4021 gtcgactaca atgtcctgat gagtatcttc caagagtccg gtaacttcgt ttcgtttgta
     4081 tacttgaata acattgctgt cgcggcaggc ggcaagcaag tatttaccgt tgggcgtgat
     4141 gttgaagttg cggggatgga tgccggtggg ctgataacct acctttgtca aggtcccatt
     4201 ttcgggattc acggcaaaga tggcgatgcc gtcttttttc agacggttgc tggcgtagag
     4261 gtatttccca tccggactga ggtggatgtc tgcacttcca cgggcggcta cggtgtcggc
     4321 tgtgatagtc tgtatttgtt ccaggcggcc gtcgtcataa ctgaaggcaa tgactttgcc
     4381 ggacagttcg gtgatgagat aggcaaactt cccgttgggg ctgaatgtca gatggcgcgg
     4441 accggaatcc gcttcaatgt caacggcttc cagagaagca tgagggatag ggttgtcggg
     4501 gtgcatcaca aatcgcagga tgcggtcggc actgaaatcg gtagcaaaga tgtattttcc
     4561 gtcaggtgaa aagaccgtgc aatggatgtg gggagtggct tgccgtatgg catcgggacc
     4621 ggtggcagag ccttgaaaga gcgtgtctgc aggagccaaa gtgccgtctt tctgtaaagg
     4681 aaagacggac atggttccac cgctgtagtt ggcagtcaac acttcccggc cattggtggc
     4741 cacgtagcag gggtcggcgc cgaaggtggg aacggtgttc agcaggcgca gttctcccgt
     4801 ttcccggtcg aaggcaaggg agctgagggc tgctgtgctg tcgttcattt cactgacggc
     4861 atagacaaat tcgccatctt ccgaggggac gaggtaggag ggattgggca atgccgctga
     4921 actgagcgga acggctgttc ccgtctcctg attaaagcgg aaggtataga tacccttgct
     4981 tgagccattc gtgtaagtac ctattagcat ggcaagttcg tcctggccac cgttagtgcc
     5041 ctttggagaa gagccacatg ctgtcaaacc taatccgagc atacagaaaa gaagtgtttt
     5101 cattaattta atgtgttaat gtgccaatat gctaatgtgc taattggctg cgctgtatat
     5161 gctgcatggt cattggtaca ttagcatatt ggcacattag cacattaaaa tttaacttcg
     5221 gcaatactga cgcggtcatc gttcagcacg atgcggaggt cgctggcggt agtgcctttg
     5281 aacggatagg aaatcagttt gccgtattcg ctgacggtgc ccgaatatac ggtgaggaac
     5341 tgtccgccac cgcccgagag ctggatttcg aaggttgccg gcaggttgtt gtcacgtgta
     5401 aaggcaatgg caactttatc taccttggct ccgttcttca aggcaaaggt aatataatct
     5461 cccttatttc cttgccatgc ggtattgatt ttttcgtcga gcacgttttc ggcatcctct
     5521 gggttggtgc tggcactcac acgctttgct ggtttttggg cttcaatggc tttggcacgg
     5581 gtctggtagt cttctacggt cagcgttccg ttcaggcgga tgtcttcgga agaggcgccg
     5641 gtcatgagca cgaagtcgcc gggttccacc acccatttca tgtcggcgtc cagaagctcc
     5701 aggtgcttgc ggtcgatggt gaaggacagc tcctgggctt cgcccggttc gaggtggatg
     5761 cgctggaagc ctgcaagatt cttttcgtag gtggtgatgc tgctcagtac gtcgcggata
     5821 tagagttgca ctacttcatc tccggcacgt ttgccggtgt tggtcacctt caggcggacg
     5881 gtggcagact cgttcggggt gatgactcgg ggggtgatgt cgaggtcgga gtactcgaag
     5941 gtggtgtagc tcaagccgta accgaagggg tagagtgctc cgttgatgcg tgacatgttg
     6001 cccgtaggtc ccggattctt accgccgtct atctgtgaag aaggtttgca ggggaagttg
     6061 aaggggattt gccctacggt cttggggaag gtcaccgtca gctttccacc ggggttgtag
     6121 tcgccgaaga ggatgtcggc cagggctgtt ccgcctttgg agccgggata ccaggcttcg
     6181 aggatagcgg ggacgaactt gtctgcccag ttgatggaga gcgggcgtcc gttgatgagt
     6241 atcagtacga cgggcttgcc cgtggcttgt atggcttgaa gcagttgcaa ctgccggccg
     6301 ggcaggtcga ggctggtgcg cgatttgttt tcgccgcagg tgcgttgtcc gccgcccaat
     6361 actacgacgg caacatcagc ttggcgggca ttttctacgg ctttgtctat ctcggcttgc
     6421 tcgtcgtcgg tcagaggata gtctatgatt tcactttcgg gccagtgggc atccactagg
     6481 tcgcagcctt tggtgtagag cacctctgcc ttgccttttg tcttttcttg aatgccttcc
     6541 agtacagtgg tcacctctac ggcaagtggg ccgtaatggg tcagcgcgta gccttcttca
     6601 ttggcattgg gaccacagac ggcaatcttc ttggtggagt tgatgtctaa gggcaacagc
     6661 tcatcggcat tcttcagcag aacgacggac tcgtgggatg cctgcaaggc gatggcttcg
     6721 ttctcttctt tttccacttc acggtcggca ccggcaaggt ctgtctggta gggggcatcg
     6781 aacagaccga tgaggaactt tacccggagg atgtcgcgca cacggtcgtt aatgacttct
     6841 tcgctcagtc cgccttcctt cactagttcg cggaggggaa ggacgaagga gtcgggcgag
     6901 cggaaggtgc agcgtacgtt cagcccggct tccacgcttt ggcggacggc ttctttcatg
     6961 tctttgacgg tgccgtgctt ggtgtagagg tattctacgg cgtcactgtc ggatacgacg
     7021 tagccacgga atcccatttc gccacgcagg cgggtggtga gccagtagta gctgccctgc
     7081 acggggatgc cgtcgtaatc gttgtacgaa ctcattacgc ccagcatgcc ggcttcccgg
     7141 atgacgcgtt tgaaagggta gatgtgtatg ttctccactt cgcgcggcga catttgcggg
     7201 tccacgcgtg ccatgccttc gcgggcgcct ttgttgttac tgtaagcggc aaagtgcttg
     7261 ccggtggcgg ccacttggtg gttgtgctgc aagccgcgca ccatttcgat gcccagttcg
     7321 gctacgaggt agggagattc gccgtaaact tcttcgtagc gtccccagcg ctggtcgcgt
     7381 cctacgtcga ggatgggggc gtagacgttg gtgtagccca gcatgcgggc ttcgcgtccg
     7441 gtgatgagtc ctacttggcg aatcagttca cggttccagg tatgtcccag tcccagttgg
     7501 gtggggaagt tggtggcgcg gtagctttcc acgccgcgta tgccttcgtt ggtaaagtct
     7561 acggggatgc cgagacgggt atcttccaca aagaaccgtt gcacctcgtt cagtgcccag
     7621 gcgtggcgcg aggcgggcca gacgtaggca ttgtccgagg gaggcagccc ccattgctgg
     7681 aagccgttca ggtgttcgtc gatggcgccg atgccgtctt tccagagcag ctctttccat
     7741 tcgggggtgg ggaggtcgtc tttcagtacg cgtttgtagc cgtagagggt gaccatttgg
     7801 caggtctttt cgtccagcgt catctgttgc agcaggtttt cgatgcgtgc ttcgagcggg
     7861 gcggaggggt cttcgtacac gtctttcact ccgtttttgt tgaagtctat ccaacctttg
     7921 cggtacattt cacttttcac cggcttgtag gttgccggtg ttttggcagg cttttgtgcg
     7981 cagagcagtg tgcttcctcc aagcagcagg gttagggcaa taaggttctt catgatatgt
     8041 tctaaaaatc tcttggttat tattgtttct tttgttgaca aaaatacggc taatgtgtga
     8101 aataaaggga taaaatagtc cgaagtatcg gcttttattg tccgaagggt cttcctctta
     8161 ctaaaaatat cctccaagac gctaccgggg aattcaaatc attattagac gaaacatatc
     8221 attcactttt aaaaagaaag aacactataa taacctgaaa agtagatgca atcgcggtgt
     8281 atacaagtat tacggctaca tctgttaaac gagggtgtat ttatataata ggaatctgtt
     8341 ggcggaattg ttgcttgtac ggaagaactt tcttttcaac cttgggatag attgcttcct
     8401 taattctttc cggtttttca gttaacttca gagacttttt ccgttaactt cccatctctt
     8461 ttgtgcaaat atccattaca gaagatagat attccctctt gcagggggta attccgtcaa
     8521 cggatactgg ctttggtagc tgtttgaaca ttgatgacaa tggggtgcac atattctatg
     8581 tatggaagat tattgttttt atcacgaaaa gtcagtatta gctaatattt gtaaatatat
     8641 ggtgattgct aataaaagaa tatgtatctt tgggccaaag aaagcggtag aggatgaaaa
     8701 ataaagtagc atttatccct ttttcaccct ccctacttag caatgagtta cgcaatcttt
     8761 taaatttcag accgttacaa agtcatgggg ttgactggat ttgacagcgg gcagaaatgg
     8821 taagtaagca tgcagtgcgt cgttgatttg cactttaatc tcagtcctca aaattttatc
     8881 tggcgaaact cgttacgctc tcgctgctta atcgaagtat agtagattga agcttaatcc
     8941 cggcaccagg tgctgggacg tgacatcact cggaagctgt tgctccgaag cattccgata
     9001 aagtggtgca gtcaaatcgg ggatagttcg tgtcagcctc gtggcgcggg tgaaaattta
     9061 gaggataagg caacggttga tggctttggt tctgccgctg cacgaaaatt taggcaaaga
     9121 taagcatgta gaaagcttat gatttcctcg tttggacgag ggttcgattc cctccagctc
     9181 cacggaaata gtaaaaagaa gtttgtaagt ccttgaattc ctgtaattca ggggcttttt
     9241 cttttcttct actcccccta ccttttatat tcatttagaa aatagttgta gtaaatgtgc
     9301 tacaattcaa aattaatatc tacttttgtc tgttcaaaaa tcaataacta ttagaagtgg
     9361 gggcaacact ttaaattctg caacagattt atgaaaattc acgaaggaaa atgtacagag
     9421 aagattttga aagaacgtga acggattggt agtcggttag ccattcttcg caagaagaga
     9481 aatatgaccc aagaggaatt ggctaatctt tgtggtgtta atcgtgttaa tatagccaag
     9541 atagagaaag gggcttataa tgtgagcatt gatatactat ctaaggtaac atccgctctt
     9601 ggttttgtga tagatataaa agtggatagc tctgtttgtc cgactcattt ctctcaacgt
     9661 aaacctgtaa agctggtaat agggaaagac tattatgtca gttttggcaa taacgaagcc
     9721 catagatgta agctggttga tattccggag atgtaccaag gtcaaagaat taaaatcgaa
     9781 actccgaccc cgagagggtc tatcacccac atattatttg ccgatgaaat aggaacgaca
     9841 cctgacgagg ctgtaatgaa ccaagtaacg atgtaaaaac attaaaaggg aggaagtgca
     9901 agttcctctt ttattgaaat caccttcgct acaaccatct gcagcgaggg tgatttttta
     9961 gtttatgagg gtttctacac accctctttc atcagggcta ttcagaaatt taatggtttc
    10021 ttctgaatat ataatcttaa attgatggtt cggaatcaat tctaaagctg ggaaatcagt
    10081 agtgattaac agttttagtc cctttcttta atatgtaaaa gcaacttgta caaaagaagt
    10141 ttcttatgta cgggatagca gcaataactc cgttgagcct tcgtggggac aagccgaatt
    10201 tgattttata atgtgggttt ataaggtaca gtctccggtc aatgatttga tagttggctt
    10261 gccgggcgat gcgattgaac agttcgatgg tgcatccggt gctctttata tccagtagct
    10321 ccgtgattac gcgttcctgc tcaccgcata gtcttaatat ccatctgtat aaagtgcggg
    10381 gaaggaggtg gagaaaaggg aaatgtgaaa caatgtggct gtgtgctatc tgctggtggc
    10441 ctccgaatgg catttgccag gcgggaaatc ctacaaatac agctccgtcg gcagacaaat
    10501 gtttttgtag gccggagagg aaccgttctt tgtctctgat atgctctatc acatcgtgta
    10561 gaagaatcag gggaaaattc gtagccttgt cctcaagctg gaaaatgtcg gtggcaatga
    10621 actgtccctg ctgatgcctt tgggcgaaga aggccctggc ttgctctatt cgcatggcat
    10681 caatgtctac gcccatcacc cggcaaccgg ctttggcaaa gggaagcaga ttgcctccct
    10741 ctccacagcc cacttccagc actttatcgg ggatgtgtcc gatgacttcc tttatgtagg
    10801 ggatataata gttcttgctg gtctgtgact gttcatcaaa gtagctttcc cggtcggtat
    10861 gtcgtttctg catgttcttt gttccttctt gagtttgatt atccatataa atagataatc
    10921 agtcgggtaa aagactgcgt ggcgcatcgt ttttttacca ggaaatgcgg aggcctaccg
    10981 ggagggtgaa tgtgaacggg tgttcctttc ggatggtgcg cagttggctg ccgtcgggga
    11041 tataatagtt tacagtcggc tccagataga tgcctgcctg gggtgtgagg cgatattgta
    11101 tgcctatact tgtgttgacc gaccactgcc agggagcact taccggctgg ctgtcgagct
    11161 tgtgtggaat actgtccgtg acatggaagc tttggagtgt tccttttatg gggatatcca
    11221 cctgtatgcc tgccgtggca taaccggaga aacgtttgta atgccagaaa cggtaggaaa
    11281 gccggagagg aatgccgata taatgcaact tctggttgtc ttgaatgcgg aatgcttcgc
    11341 cggtagtgaa ctccgacctg agaagcgtat attgcaatcc ggtttccaga ctccaacgct
    11401 cattcaattt cttgctgaga gagagtccca cgacgatggg ggcatgatgt tgctggttct
    11461 caacaatcct gccgctgtta ttctgggcaa tctgcatgag tccgatggaa tcttttccca
    11521 gagtaccctg ctgatagcgg gtgtgcagat aagaataata ctcttcccac gtgctgactt
    11581 gttgagggaa gtcacttgaa atgccgtcgg tatgtggagt ggcaatcagc ttatataagt
    11641 tctgtgtcag ttgcggtccg agtgaaccag ccagcatcaa cttccatttt ccggatttct
    11701 tcttgcgggt tggcggcatc agggaagggg agaagacgaa agccatctgt cggttggtga
    11761 tggtctgtcc ggtgaatgga gaaggtatgg gatatttgtg gatgctatct ttcattgtgg
    11821 gtatggcaag gggccattct gtggaaactg gaacgggagg gatgattcgt tcccttttgt
    11881 tcagattttc tttggtatgg cattgttcgt cggttcgggg agtatcggtt ttctttgttt
    11941 gttgcgtact cccggcttgc ctggaagaaa ctttggacaa acggttttcc ctgatactct
    12001 ttttctctct gtacagatag tcatacagcg ttggaaagag aagcaatact gtcaaaacaa
    12061 tgaatacacg gtatcctgcc agcatctttt taagtaaaat tttcgcccgg aacaattggg
    12121 aggaagagga gtgtggcgct atacccagta aatctccgat ttctttgtgg gacaatcctt
    12181 ccagtactgc cagtttaaat accttgcagt agccctccgg aaggctctcc actatatcca
    12241 gcatcttatc gtacgaaatg aaatccggac aaaaaggatt ttcagcaggc tcttcctctt
    12301 ccggaatatc tgtcaatggg atggtggggt tggcattggc atggttgagg tattgcagtg
    12361 ccaggtttct cataatcttt ttcatccagt attccagttt ctccgggttg cgcagcgaat
    12421 gaatggaagt gaatatgatg acaaaaccgt cgtgaagaag atcttgggct atcgttgggt
    12481 cgggaatata gcgtaggcat actttcagca ttttctctga atagttttcg tagagcaggc
    12541 tcaaggcctg cccgtttccc ttctggcata aagtgacaag agcttttgta tccatgtgtt
    12601 tgtctcaatg ttatttctta aggatagaga agaacatgaa tgactgcatg gatttttatt
    12661 ttttaactaa gccccccggt tggcttctgc tgcacagtcc ggacaaatgc ctttcagtac
    12721 atagttgatg ctgttcagtg taaatccttg aggcagcttc accaccggag tgggaatgtt
    12781 ggtgaagcag aaggttttgt tgcatttctc gcaatggaaa tgggtgtgca ggtcgcttac
    12841 gtcgcaagag ca
//
