LOCUS       gnlProkkaCHADNLBK_11   15496 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CHADNLBK_11.
ACCESSION   gnlProkkaCHADNLBK_11
VERSION     gnlProkkaCHADNLBK_11
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 01:45:09
            Original ID  :: gnl|Prokka|CHADNLBK_11
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15496
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15496
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5268:5496]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5269..5496
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15496
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15496
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(105..428)
                     /locus_tag="ctg11_1"
                     /transl_table=11
                     /translation="MFVDGADTVFPEQLFPFGGGEVVFQYTFVTVEGDHLAGLFVQRHL
                     LQQVFDACFERGGGVFVHVFHSVFVEVYPTFAVHFTFHRLVGCRCFGRLLCAEQCASSK
                     QQG"
     CDS             complement(429..1181)
                     /locus_tag="ctg11_2"
                     /transl_table=11
                     /translation="MADGFFHVFGGAVLGVEVFYGVTVGYDVATESHFATQAGGEPVVA
                     ALHGDAVVIVVRTHYAQHASFPDDAFEGVDVYVFHFARRHLRVHACHAFAGAFVVTVSG
                     KVLAGGGHLVVVLQAAHHFDAQFGYEVGRFAVNFFVASPALVASYVEDGGVDVGVAQHA
                     GFASGDESYLANQFTVPGMSQSQLGGEVGGAVAFHAAYAFVGKVYGDTETGIFHKEPLH
                     LVQCPGVARGGPDVGIVRGRQPPLLEAV"
     CDS             complement(1470..2051)
                     /locus_tag="ctg11_3"
                     /transl_table=11
                     /translation="MPYGLGEGHRQLSTGVVVAEEDVGQGCSAFGAGIPGFEDSGDELV
                     CPVDGERASVDEYQYDGLARGLYGLKQLQLPTGQVEAGARFVFAAGALSAAQYYDGNIS
                     LTGIFYGFVYLGLFVVGQRIVYDFTFGPVGVHQVAAFGVEHLCLAFCLFLNAFQHSGHF
                     YGKWAVMGQRVAFFIGIGTTDGNLLGGVDV"
     CDS             complement(2127..2417)
                     /locus_tag="ctg11_4"
                     /transl_table=11
                     /translation="MLAVDGEGQLLGFARFEVDALEACKILFVGGDAAQYVADIELHYF
                     ISGTFAGVGHLQADGGRLVRGDDSGGDVEVGVLEGGVAQAVAEGVECSVDA"
     CDS             2439..2915
                     /locus_tag="ctg11_5"
                     /transl_table=11
                     /translation="MKWVVEPGDFVLMAGASSEDIRLNGTLTVEDYQTRAKAIEAQKPA
                     KRVSASTNPEDAENVLDEKINTAWQGNKGDYITFALKNGAKVDKVAIAFTRDNNLPATF
                     EIQLSGGGGQFLTVYSGTVSEYGKLISYPFKGTTASDLRIVLNDDRVSIAEVKF"
     CDS             3017..4144
                     /locus_tag="ctg11_6"
                     /transl_table=11
                     /translation="MKTLLFCMLGLGLTACGSSPKGTNGDQDELAMLIGTYTNGSSKGI
                     YTFRFNQETGTAVPLSSAALPNPSYLVPSEDGEFVYAVSEMNDSTAALSSLAFDRETGE
                     LRLLNTVPTFGADPCYVATNGREVLTANYSGGTMSVFPLQKDGTLAPADTLFQGSATGP
                     DAIRQATPHIHCTVFSPDGKYIFATDFSADRILRFVMHPDDPIPHASLEAVDIEADSGP
                     RHLTFSPNGKFAYLITELSGKVIAFSYDDGCLEQIQTITADTVAARGSADIHLSPDGKY
                     LYASNRLKEDGIAIFAVNPENGTLAKVGYQPTGIHPRNFNITPNGKYLLAACRDSNVIQ
                     VYKRNEVTGLLEDTHQDIVVDMPVCVQFVSSVNNL"
     CDS             4206..5261
                     /locus_tag="ctg11_7"
                     /transl_table=11
                     /translation="MYIMKKNILMLSALFLSITAMAQTDVTTGVMRGKDYGVTYMLPKT
                     EIEIVLQATKHTYTPGEFCRYADRYLRLNNVSAEPEEFWTLDKIETRIAGVPDKDNVYF
                     VKMKDKTVAPLMELTEDGIVRSINIPFSGKPAAKTPEAKATESSIDPRSFLTEEILMSN
                     SSAKMAELVAKEIYSIRESKNALLRGEADMPKDGAQLKLMLDNLNQQETAMTEMFSGKI
                     KKEPKTFTIRLTPKEMKDEVAFRFSRKLGVVANNDLAGEPYYISVTDLKSPDVSATEEG
                     KKKVDGVAYNLPGKAQVTLMYNNKKLFDDQLPITQFGTVEYLAPVLFNKNSTIKVLFDT
                     ATGGLIKVDRE"
     CDS             complement(5269..5496)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_8"
                     /sec_met_domain="PqqD_RRE (E-value: 3.6e-10, bitscore:
                     30.6, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.6e-17, bitscore: 54.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRFLLPKGMSPDIHVRLEEHGTAVWNLIDGHRTVREIISLLARH
                     FGEEENYIPRVTAYVMQLRKDGFIQLTIRN"
     CDS             complement(5642..6442)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 78.6; E-value: 5.9e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg11_9"
                     /transl_table=11
                     /translation="MLLGLVLLLGGMIAFFIFAVMDKKLDKQMEAAAIAAGTEDEEEKF
                     SFKDVKNILVNPGFWLIALLCVLFYSCVFPFQKFASELMIIKYGINENVAGTFAGLPAL
                     GALILTPVFGGFIDKRGKSASIMLLGSAMLICVHFIYAIPDINYWLVAIVLMIILGIAF
                     SLVPSAMWPAVAKIFPVSQLGTAYALIFFIQNIGLWGIPTLIGWVLDAYCISGKKPDGT
                     NMYDYTVPMCIFTGIACLSLIVALLLKKADKKYGYKLEEPNIQK"
     CDS             complement(6610..7053)
                     /locus_tag="ctg11_10"
                     /transl_table=11
                     /translation="MTEQLKLKLNDSKATRWGALVIVAFTMMVAYYVNDVVAPLKTMLE
                     TDLAWSSTDFGFFTGGYSFLNVFFLMLIWGGLILDRFGIRFTGKLATILMVGGTALEYY
                     AMTGLAGADATLFGINEIFGYKTGVFVAFAGYSIFXXXXXXXX"
     CDS             complement(7207..7596)
                     /locus_tag="ctg11_11"
                     /transl_table=11
                     /translation="MYLLLVILMLIASVLMCFIVLIQNSKGGGLASGFSSSNQIMGVRK
                     TTDFLEKATWTLAAVMVVFSIVSAYTIPSSTGKGGDVILEQAQQEEKTNPYNMPVGTEA
                     PQSEAPAATTPAETPAPAAEAPAAE"
     CDS             complement(7601..8374)
                     /locus_tag="ctg11_12"
                     /transl_table=11
                     /translation="MTPTHLQQWIQHPETLNRDTLYELRTLVARYPYFQSLRLLYLKNL
                     YLLHDINFGAELRKAVLYVADRRVLFYFIEGDRYTLKSRKVSSLFSGDLEKEPSVDRTL
                     SLIDAFLATVPEEHSQHTELDYAVDYTAYLMQEEPGVDAEDESEVPKLRGHELIDDFIQ
                     KSESSDASDTRREFLVEKEEETEEEEEPSVSPVTEELDDSCFTETLAKIYIKQHRYDKA
                     LEIIKKLSLNYPKKNAYFADQIRFLEKLIINAKSK"
     CDS             complement(8379..8846)
                     /locus_tag="ctg11_13"
                     /transl_table=11
                     /translation="MNSCSMKLGLAPISSIDYTKVKTISIADFQNRAEYVYAPLATEFN
                     QKMKDMFIQQTRLQLVNSGGDLEIDGEITGYNQYNESVDASGYSSKVKVTLTVNVRYTN
                     NTNHEEDFEQQFSAFQTYDSSKLLTEVQDQLITLMVKDIAEQIFNATVANW"
     CDS             complement(8890..10140)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 379.9; E-value:
                     3.1e-115)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg11_14"
                     /transl_table=11
                     /translation="MTKAEIQQVKLRFGIIGNNEALMRAIDIAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EANGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVEKTDVRIVAATNVNLTQAI
                     ADGRFREDLYYRLNTVPIQVPPLRERGEDVVLLFRKFASDFAEKYRMPAIQLTEDGKQV
                     LLGYSWPGNVRQLKNITEQISIIETNREINASILKGYLPEQNNMQRLPALFGVKEDKSF
                     GSEREILYQVLFDMRQDVTDLKKLVHEIMAERGTVANPAVATSAYYTPATPAVVPPVTS
                     SVPTIIHPSVKPVTPVDDDFQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAQDL
                     NISERTLYRKIKEYGLD"
     CDS             complement(10142..11239)
                     /locus_tag="ctg11_15"
                     /transl_table=11
                     /translation="MEDNKIRVGITQGDINGVGYEVILKTFADPVMLELCTPIIYGSPK
                     VAAYHRKSLDLPTNFSIVNSASEAVPNRLSVVNCTDDEVKVEFSKPDVEAGKAALGALE
                     KAIEEYKEGMIDVIVTAPINKHTIQSEEFAFPGHTEYIEQKLGDGEKALMILMKDDFRV
                     ALVTGHIPVKEIAGSITKELIQEKLKIFNRSLKQDFAISAPRIAVLSLNPHAGDGGLLG
                     TEEQEIIIPAINEMAAKGMLCYGPYPADGFMGSDNFTHFDGILAMYHDQGLAPFKALAM
                     DEGVNYTAGLPVIRTSPAHGTAYDIAGKGIASEDSFRQAIYVAIDVFRNRQREKEAHAN
                     PLRKQYYEKRDDSDKLKLDSVEEDL"
     CDS             complement(11245..12300)
                     /locus_tag="ctg11_16"
                     /transl_table=11
                     /translation="MRKHLFYLSMVLVLTLFSACGGGKKGVFTPTSSGRAYEVLVVVEP
                     GLWERPAGRALFDVLDSDVPGLPQSERSFRIMYTAPSNYDATLKLIRNIIIVDVNKDLY
                     TQPKFKYARNVYAAPQSILTIQAPDEASFEKFVEENRQVIIDFFTHAEMNRQISVLKDK
                     HSDYIATKVKSQFDCDVWVPGELTSTKEGENFFWAGTNAATGDQNFVIYSYPYTDKDTF
                     TKEYFVHKRDSVMKVNIPGAREGMYMSTDSLMTDVRPISVQGDYALEARGLWRIKGDFM
                     GGPFVSHVRLDKANQRIIVSEIFIYSPDKMKRNLVRQMEASLYTLKLPGSKQEGTEIPV
                     GVTSKDTTNNK"
     CDS             complement(12371..13411)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_17"
                     /sec_met_domain="PF04055 (E-value: 5.2e-17, bitscore: 53.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKRPLLGLTLSELQNVVKNLGMPGFSAKQIASWLYGKKVTSIDE
                     MSNLSLKHRELLKEIYEVGAEAPVDAMRSVDGTVKYLYRAGEGHFVEAVYIPDEDRATL
                     CVSSQVGCKMNCKFCMTGKQGFTANLTSNQIINQINSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALEIMTASYGYAWSPKRVTLSSVGLKKGLQRFIEESDCHLAISLHSPIPLQRRE
                     LMPAEKAFSITEIVELLRNYDFSKQRRLSFEYIVFKGVNDSLPYAKELLKLLRGLDCRI
                     NLIRFHAIPGVNLEGADMETMTAFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEE
                     NKEELI"
ORIGIN
        1 actattttat ccctttattt cacacattag ccgtattttt gtcaacaaaa gaaacaataa
       61 taaccaagag atttttagaa catatcatga agaaccttat tgccctaacc ctgctgcttg
      121 gaggaagcac actgctctgc gcacaaaagc ctgccaaaac accggcaacc tacaagccgg
      181 tgaaaagtga aatgtaccgc aaaggttgga tagacttcaa caaaaacgga gtgaaagacg
      241 tgtacgaaga cccctccgcc ccgctcgaag cacgcatcga aaacctgctg caacagatga
      301 cgctggacga aaagacctgc caaatggtca ccctctacgg ttacaaacgt gtactgaaag
      361 acgacctccc cacccccgaa tggaaagagc tgctctggaa agacggtatc ggcgccatcg
      421 acgaacacct aaacggcttc cagcaatggg ggctgcctcc ctcggacaat gcctacgtct
      481 ggcccgcctc gcgccacgcc tgggcactga acgaggtgca acggttcttt gtggaagata
      541 cccgtctcgg tatccccgta gactttacca acgaaggcat acgcggcgtg gaaagctacc
      601 gcgccaccaa cttccccacc caactgggac tgggacatac ctggaaccgt gaactgattc
      661 gccaagtagg actcatcacc ggacgcgaag cccgcatgct gggctacacc aacgtctacg
      721 cccccatcct cgacgtagga cgcgaccagc gctggggacg ctacgaagaa gtttacggcg
      781 aatctcccta cctcgtagcc gaactgggca tcgaaatggt gcgcggcttg cagcacaacc
      841 accaagtggc cgccaccggc aagcactttg ccgcttacag taacaacaaa ggcgcccgcg
      901 aaggcatggc acgcgtggac ccgcaaatgt cgccgcgcga agtggaaaac atacacatct
      961 accccttcaa acgcgtcatc cgggaagctg gcatgctggg cgtaatgagt tcgtacaacg
     1021 attacgacgg catccccgtg cagggcagct actactggct caccacccgc ctgcgtggcg
     1081 aaatgggatt ccgtggctac gtcgtatccg acagtgacgc cgtagaatac ctctacacca
     1141 agcacggcac cgccaaagac atgaaagaag ccgtccgcca aagcgtggaa gccggactga
     1201 acgtacgctg caccttccgc tcgcccgact ccttcgtcct tcccctccgc gaactggtga
     1261 aggaaggcgg actgagcgaa gaagtcatca acgaccgcgt gcgcgacatc cttcgggtaa
     1321 agttcctcat cggtctgttc gatgccccct atcagacaga ccttgccgat gccgaccgtg
     1381 aagtggaaaa agaagagaac gaagccattg ccttgcaggc atcccgcgag tccatcgttc
     1441 tgctgaagaa tgccggtgaa ctattgccct tagacatcaa ctccaccaag aagattgccg
     1501 tctgtggtcc caatgccaat gaagaaggct acgcgctgac ccattacggc ccacttgccg
     1561 tagaagtgac cactgtgctg gaaggcattc aagaaaagac aaaaggcaag gcagaggtgc
     1621 tctacaccaa aggctgcgac ctggtggacg cccactggcc cgaaagtgaa atcatagact
     1681 atccgctgac cgacgacgaa caagccgaga tagacaaagc cgtagaaaat gcccgtcaag
     1741 ctgatgttgc cgtcgtagta ttgggcggcg gacaacgcac ctgcggcgaa aacaaatcgc
     1801 gcaccagcct cgacctgccc ggtcggcagt tgcaactgct tcaagccata caagccacgg
     1861 gcaagcccgt cgtactgata ctcatcaacg gacgcccgct ctccatcaac tgggcagaca
     1921 agttcgtccc cgctatcctc gaagcctggt atcccggctc caaaggcgga acagccctgg
     1981 ccgacatcct cttcggcgac tacaaccccg gtggaaagct gacggtgacc ttccccaaga
     2041 ccgtagggca aatccccttc aacttcccct gcaaaccttc ttcacagata gacggcggta
     2101 agaatccggg acctacgggc aacatgtcac gcatcaacgg agcactctac cccttcggct
     2161 acggcctgag ctacaccacc ttcgagtact ccgacctcga catcaccccc cgagtcatca
     2221 ccccgaacga gtctgccacc gtccgcctga aggtgaccaa caccggcaaa cgtgccggag
     2281 atgaagtagt gcagctctat atccgcgacg tactgagcag catcaccacc tacgaaaaga
     2341 atcttgcagg cttccagcgc atccacctcg aaccgggcga agcccaggag ctgtccttca
     2401 ccatcgaccg caagcacctg gagcttctgg acgctgacat gaaatgggtg gtggaacccg
     2461 gcgacttcgt gctcatggcc ggcgcctctt ccgaagacat ccgcctgaac ggaacgctga
     2521 ccgtagaaga ctaccagacc cgtgccaaag ccattgaagc ccaaaaacca gcaaagcgtg
     2581 tgagtgccag caccaaccca gaggatgccg aaaacgtgct cgacgaaaaa atcaataccg
     2641 catggcaagg aaataaggga gattatatta cctttgcctt aaagaacgga gccaaggtag
     2701 ataaagttgc cattgccttt acacgtgaca acaacctgcc ggcaaccttc gaaatccagc
     2761 tctcgggcgg tggcggacag ttcctcaccg tatattcggg caccgtcagc gaatacggca
     2821 aactgatttc ctatccgttc aaaggcacta ccgccagcga cctccgcatc gtgctgaacg
     2881 atgaccgcgt cagtattgcc gaagttaaat tttaatgtgc taatgtgcca atatgctaat
     2941 gtaccaatga ccatgcagca tatacagcgc agccaattag cacattagca tattggcaca
     3001 ttaacacatt aaattaatga aaacacttct tttctgtatg ctcggattag gtttgacagc
     3061 atgtggctct tctccaaagg gcactaacgg tgaccaggac gaactcgcca tgctaatagg
     3121 tacttacacg aatggctcaa gcaagggtat ctataccttc cgctttaatc aggagacggg
     3181 aacagccgtt ccgctcagtt cagcggcatt gcccaatccc tcctacctcg tcccctcgga
     3241 agatggcgaa tttgtctatg ccgtcagtga aatgaacgac agcacagcag ccctcagctc
     3301 ccttgccttc gaccgggaaa cgggagaact gcgcctgctg aacaccgttc ccaccttcgg
     3361 cgccgacccc tgctacgtgg ccaccaatgg ccgggaagtg ttgactgcca actacagcgg
     3421 tggaaccatg tccgtctttc ctttacagaa agacggcact ttggctcctg cagacacgct
     3481 ctttcaaggc tctgccaccg gtcccgacgc catacggcaa gccactcccc acatccattg
     3541 cacggtcttt tcaccggacg gaaaatacat ctttgccacc gacttcagtg ccgaccgcat
     3601 cctgcgcttt gtgatgcacc ccgacgaccc tattcctcat gcttctctgg aagccgttga
     3661 cattgaagcg gattccggcc cgcgccatct gacattcagc cctaacggga agtttgccta
     3721 tctcatcacc gaactgtccg gtaaggtcat tgccttcagt tacgacgacg gctgcctgga
     3781 acagatacag actatcacag ccgacaccgt agccgcccgt ggaagtgcag acatccacct
     3841 cagtccggat gggaaatacc tctacgccag caaccgtctg aaagaagacg gcatcgccat
     3901 ctttgccgtg aatcccgaaa atgggacctt ggcaaaggta ggttatcagc ccaccggcat
     3961 ccatccccgc aacttcaaca tcacgcccaa cggcaaatac ttgcttgccg cctgccgcga
     4021 cagcaatgtc attcaggtat acaaacgaaa cgaagttacc ggactcttgg aagatactca
     4081 tcaggacatt gtagtcgaca tgccggtttg cgtacagttc gtcagctctg ttaataattt
     4141 ataaagcaat atttagcaaa gataacttca ttaactttgt cccttagcta aatcagtcta
     4201 aacgaatgta cattatgaag aagaatatat tgatgctctc agctctgttc ttgtctatca
     4261 ctgccatggc gcaaacagac gtaaccaccg gtgtgatgcg tggcaaagac tacggagtga
     4321 cttatatgtt gcccaaaaca gaaatagaaa tcgtattgca agccaccaag catacctaca
     4381 ctcccggaga attttgcaga tatgccgacc gctatctgcg tctcaacaac gtgtctgccg
     4441 aacccgagga gttctggaca ctggataaga tagaaacccg catagccggt gtaccggata
     4501 aggacaacgt ctatttcgtg aagatgaaag acaagaccgt agcacccctt atggagctta
     4561 ccgaagacgg aattgtccgc tccatcaaca ttccgttcag cggtaagcct gctgccaaga
     4621 cgcccgaagc caaagccacc gaaagcagca ttgacccacg cagttttctg acggaagaaa
     4681 tactgatgtc caactccagt gccaagatgg ccgagctggt ggccaaggaa atatacagca
     4741 tccgcgaaag caagaatgcc ctcctgcgcg gcgaagcaga catgcccaag gacggcgccc
     4801 aactcaagct gatgcttgac aatctgaacc agcaggaaac ggctatgacg gaaatgttct
     4861 cgggcaaaat aaagaaagaa cccaagacat tcaccatccg gctgacgcct aaagagatga
     4921 aagatgaggt ggctttccgt ttttcccgga agctgggagt ggtggccaat aatgaccttg
     4981 ccggtgaacc gtattatatc agcgtcaccg acctcaaaag tcccgatgta tctgccaccg
     5041 aggaaggcaa aaagaaagtg gacggtgtag cctataacct tccgggcaag gcacaagtga
     5101 cattgatgta taacaataag aaattgtttg acgaccaact tcccattacc caattcggca
     5161 ccgtagaata cctcgcaccg gtactgttca acaagaattc taccatcaaa gtgctgtttg
     5221 atacggcaac gggaggattg ataaaagtag atagggaata aaggaattct aattccggat
     5281 tgtcaactgg ataaatccat ccttacgcaa ctgcattacg taggcggtga cccggggaat
     5341 ataattctct tcctccccaa agtgcctggc aagtagagag atgatttcgc gcacggtacg
     5401 atgtccatct atcagattcc agacagctgt accgtgttct tccagcctca catggatgtc
     5461 aggagacatc cccttcggca ataaaaaacg acgcatccat tcgtatttaa accgtgggta
     5521 ggcgagtacg gcgcactcac cttcccattc ggttgttata tgtccacagc ggaccggaac
     5581 agcgtccaac agacttactt ttccttcggg tatttccatc atacggtatc cgcttttcct
     5641 attatttctg aatattaggc tcttccagct tataaccata cttcttgtct gccttcttca
     5701 gcagtagagc cactataagg gacaagcagg caataccggt aaaaatgcac ataggcaccg
     5761 tatagtcata catattcgtt ccatctggtt tcttgccgga tatacaatag gcatcaagca
     5821 cccaccctat caatgtagga ataccccaaa gaccgatatt ctggataaag aaaatcaatg
     5881 cgtatgccgt acccaactgg cttaccggga atatcttggc cacagccggc cacatggcag
     5941 aaggtaccag cgagaaagcg atacccaaaa ttatcatcag cacaatagct accagccaat
     6001 agtttatatc gggaatagca taaatgaaat gcacacatat cagcatggcc gagcccagca
     6061 gcatgataga tgcggacttg ccccgcttgt caatgaaacc accaaagacc ggagtcagaa
     6121 tcagcgctcc caatgccgga agtccggcaa atgtaccggc cacattctca ttgataccgt
     6181 atttgataat catcaactcg gaagcaaact tctggaatgg gaatacacaa gagtagaaca
     6241 atacacacag caatgctatc agccagaaac cgggattgac cagaatattc ttcacatcct
     6301 taaaagagaa cttctcttcc tcatcttccg taccggcagc aatggcagca gcttccatct
     6361 gtttgtccag cttcttgtcc atcactgcaa agatgaagaa agcaatcata ccgcccaaca
     6421 acagaaccaa acccaacaac accggtgtgg aaataccgaa agcgcgggcc aaaggaatgg
     6481 ctacggcata accggcttgc gaaccgatac gtgctaaagc gacttgtacc cccatagccg
     6541 tggcaagctc tttcccctta aaccacttgg ctatgatttt ggaaactgta ataccggcga
     6601 cctccgctcc tacnnnnnnn nnnnnnnnnn nnnnncaaaa atggaataac cggcaaaagc
     6661 aacaaacaca cccgttttat agccaaatat ttcattgatt ccgaataaag tcgcgtcggc
     6721 accggcaagt cccgtcattg catagtattc aagtgctgta ccacctacca tcaggatagt
     6781 tgccagcttt ccggtgaaac ggataccaaa gcggtcgagg attaatcctc cccaaatcaa
     6841 catcaggaaa aaaacattca gaaaactata accaccggta aagaatccga aatcggtact
     6901 cgaccaagcc aagtccgttt ccaacattgt cttcaacggt gctaccacgt cgtttacata
     6961 ataagctacc atcatcgtga aggcaacaat caccaatgcc ccccaacggg tagccttgga
     7021 atcattcaat ttaagtttga gttgttctgt cattgtacta tttggatttc aatttattaa
     7081 tcagattgca taaattgctg acaaaggtaa ataaatactt catcaaaacg aaaaaaggct
     7141 gacacctttt cagtatcaac ctttctctta tttttccaag cgggagtcat ccgcaatatc
     7201 cttatcttat tctgctgcag gggcttctgc tgcaggagca ggagtttcag ccggagttgt
     7261 agctgcaggg gcctccgatt gcggagcttc tgtacctacg ggcatgttat aaggattagt
     7321 tttttcttct tgttgcgcct gttccagaat cacatcaccg cccttgcctg tggaagaagg
     7381 aatagtgtaa gcagaaacaa tactgaagac taccatgaca gctgccagag tccaggttgc
     7441 tttttccaaa aagtccgtag tcttgcgcac acccataatt tggttggatg atgaaaagcc
     7501 tgatgccaga ccacctcctt tagaattttg aatcaataca atgaagcaca tcagcacaga
     7561 tgcaatcagc attaagataa ctaataataa atacattttg ttattttgat ttagcgttaa
     7621 taatcaattt ctccaaaaat ctgatttggt ctgcaaagta agcatttttt tttggataat
     7681 tcaaacttaa ttttttaata atttcaagcg ccttgtcata tcggtgctgt tttatataga
     7741 ttttggctaa agtttccgta aaacagctat cgtccaactc ttccgttacc ggcgatactg
     7801 agggttcttc ctcttcttca gtctcttcct ccttctctac aagaaactcc cttctcgtat
     7861 ccgaggcatc cgaagactca ctcttttgga taaagtcatc tatcaattca tgcccgcgca
     7921 gtttaggcac ttccgactca tcttctgcat ccacaccggg ttcttcctgc attaaatagg
     7981 ccgtataatc caccgcataa tccagctccg tatgctgtga atgctcttcg ggaacagtag
     8041 ccagaaatgc gtcaatcaag gaaagggtac ggtccacact cggctctttc tccaaatcgc
     8101 cggaaaacag cgacgagacc ttccgggatt tcaaagtata gcggtcaccc tctataaagt
     8161 aaaacagcac acgacggtct gccacataca acacagcctt gcgcaactcc gcgccaaagt
     8221 tgatgtcgtg cagcagatag aggtttttca gatagagcaa acggagcgac tggaaataag
     8281 gatagcgtgc caccaatgtg cgaagctcgt acaaagtatc cctattcagc gtctcgggat
     8341 gctgaatcca ttgttgcaaa tgggtaggcg tcatgagttt accagttagc tacagttgca
     8401 ttgaaaatct gttcggcaat gtctttcacc atcaaggtta tcagctggtc ctgcacttcg
     8461 gtcagcaatt ttgaggaatc ataggtctgg aaagccgaga actgctgttc aaagtcctcc
     8521 tcatggttcg tgttattggt gtagcgcacg ttgacagtca gcgtcacctt caccttcgaa
     8581 gagtagccgc tggcatccac cgattcatta tattgattgt agccggttat ttctccgtct
     8641 atttccaggt ctcctccgga attcaccagt tgcaggcgag tctgctgaat gaacatatcc
     8701 ttcattttct ggttaaattc tgttgccagc ggtgcatata catactctgc ccggttctgg
     8761 aaatcggcaa tggaaatcgt ttttaccttt gtatagtcga tagagcttat cggagcaagt
     8821 cccaacttca tactacatga attcaccaga aataacaagc ttaccaacaa ggaagcaaat
     8881 gccgcttttt taatccaatc catattcttt tatctttctg tataacgtac gctcagagat
     8941 attcaaatcc tgagccgcac tcttacgctt gccgtgatgt ttttcaagcg ccttacgtat
     9001 catttctttc tccacttcat ccagggagag tgactcctcc acatattctt ccgtatcctg
     9061 gaaatcatcg tccaccggag taaccggctt taccgaagga tgtataatgg tggggacact
     9121 ggatgttacc ggaggtacca ccgccggagt agccggcgta tagtaggccg atgtggcaac
     9181 cgccggattg gctaccgttc ccctttcagc cataatctca tgcaccaact ttttcaagtc
     9241 cgttacatcc tggcgcatat caaacagaac ctggtagaga atttcccgtt cactcccaaa
     9301 gctcttgtcc tccttcactc caaacaaggc aggcaggcgc tgcatattgt tctgctcagg
     9361 cagatagccc ttcagtatgg atgcattgat ttcacgattg gtctcaatga tggatatctg
     9421 ctcggtgata ttcttcaact ggcgcacatt acccggccat gagtagccca gcaacacttg
     9481 cttgccgtct tccgtcagct gaatggcagg catacggtac ttttctgcaa agtccgaagc
     9541 aaactttcgg aacagcagca ccacgtcttc accgcgttcg cgcaatggag ggacctgaat
     9601 aggaactgtg ttcaaacggt aatacaagtc ttcacgaaaa cgtccgtcag caatggcttg
     9661 tgtcaagttt acattggtag cggcaacaat acgcacatcg gtcttttcca ccttagaaga
     9721 acctactttg atgaattcac cgctctcgag cacacgcaac aagcgtgcct gggtaggcaa
     9781 aggcaattcg ccgacttcat caaggaagat tgttccgccg ttggcctcac cgaaataccc
     9841 cttccgttcg ccgatagccc cggtaaatgc gcccttctca tgaccgaaca gttccgagtc
     9901 aatcgtccct tcgggaatgg ctccacagtt cacggcaatg tactgtccat gcttgcgccg
     9961 gctgtactgg tgtattatct gcggaaagct ctcctttccc acaccactct ctccggtaat
    10021 cagtacagac aagtcggtgg gcgctacctg gatagcgata tcaatggcac gcatcagcgc
    10081 ttcattgttg ccgataatgc cgaaacgtaa ttttacttgt tgtatttccg cttttgtcat
    10141 tctacaaatc ttcttctaca ctatcgagtt tcagtttgtc gctatcgtca cgtttctcgt
    10201 aatattgctt gcgcagcgga tttgcatgtg cctctttctc acgctggcgg ttacggaaca
    10261 catctattgc cacatagata gcctgccgga atgaatcttc agaggcgatt cctttcccgg
    10321 caatatcgta ggccgtgcca tgagcaggcg aagtgcgtat caccggcaag ccggcagtat
    10381 agttcacgcc ctcgtccata gccaatgcct tgaacggtgc cagcccctgg tcgtgataca
    10441 tggccaggat accatcaaaa tgggtaaagt tatctgagcc cataaacccg tctgccggat
    10501 aaggaccata gcaaagcata cccttagcag ccatttcgtt gatggccgga atgataatct
    10561 cctgctcttc agttcccagc aatccgccgt ctcctgcatg cggattcagc gaaagcactg
    10621 caatacgcgg tgcgctgata gcaaaatcct gcttcaagga gcggttgaat atcttcagtt
    10681 tttcttgtat cagttctttg gtgatgcttc cggctatctc tttaacggga atatgtccgg
    10741 tcaccaatgc tacccggaag tcatctttca tcagaatcat aagggccttc tcgccatctc
    10801 ccaatttttg ctctatatac tccgtatgtc cggggaaggc aaactcctcc gactggatgg
    10861 tatgcttgtt gatgggagct gtgacaatca cgtctatcat tccctcctta tattcctcaa
    10921 tggctttttc cagtgcacca agtgcagctt taccagcttc aacgtcaggt ttagagaact
    10981 caacctttac ttcatcatcc gtacagttca ctacactcaa gcgattggga accgcttcgg
    11041 aggcggagtt gacgatactg aagttggtag gcaagtccaa tgatttacga tgataagctg
    11101 ccactttagg cgaaccgtag ataatcggcg tgcacaattc cagcatcacc gggtctgcaa
    11161 acgtctttaa aatcacttca taccctacac cattaatgtc gccttgtgta atgccgactc
    11221 ttattttgtt gtcttccatt tttattactt attattagta gtatcttttg aggttacgcc
    11281 taccggaatt tccgtacctt cctgcttgct gccgggcagt ttcaaggtat agagcgaagc
    11341 ctccatctga cgtaccagat tacgtttcat tttatcaggt gaataaataa atatttcaga
    11401 tacgataata cgctgattgg ccttgtccaa acgtacatgc gatacgaacg gaccgcccat
    11461 gaagtcaccc tttatgcgcc acaagccgcg ggcctccagt gcatagtctc cctgcacact
    11521 gatggggcgt acatcggtca tcagagaatc cgtcgacata tacatgcctt cacgggcacc
    11581 agggatatta accttcatca cggaatcgcg tttatgaaca aaatattctt tagtaaacgt
    11641 atccttatcc gtataaggat aagagtagat tacaaagttc tggtcgccgg tagctgcatt
    11701 cgtacctgcc cagaagaagt tctcaccctc cttggtagat gtcagttcgc ccggcaccca
    11761 tacatcgcaa tcgaactggc ttttcacctt cgttgctata tagtcgctat gcttgtcctt
    11821 caatactgaa atctgacgat tcatttccgc atgggtaaag aaatcgatga ttacctgcct
    11881 gttctcctcc acaaatttct cgaacgaagc ctcgtccggt gcctgaatag tgagaataga
    11941 ctgaggagca gcatatacat tccttgcata cttgaattta ggctgggtat agaggtcctt
    12001 gttcacatcg acaataatga tattgcgaat cagttttaaa gtggcatcat aattggaagg
    12061 ggcagtatac atgattcgga atgaacgttc tgactgggga agccccggaa catcagaatc
    12121 aagcacatcg aaaagcgccc taccggcagg acgttcccac aagccgggct ccaccactac
    12181 cagaacttca tacgcacgac cgctggaggt cggagtaaac acaccctttt taccaccacc
    12241 gcaagcggaa aaaagtgtca gtacgagaac catacttaaa taaaacaagt gctttctcat
    12301 atctctatca ttttagtttt tcacaaagct acgaagaatg cgtaatatcc tccctaccta
    12361 agttaataat ttatattaat tcttctttat tctcctcctg cttggcagtg gacaacatgc
    12421 cacaagcggc aaatatatcc tctccacgcg atgaccgtat agtggtaaac agaccgtgcg
    12481 aagtcagata atcacggaac gcagtcatgg tttccatatc agccccttca agattcactc
    12541 caggtatggc atgaaaacga atcaggttaa tccggcagtc cagcccgcgt agcaacttca
    12601 gaagttcctt tgcatacggt aacgagtcat tcactccttt gaaaacaata tattcaaaag
    12661 atagtctgcg ctgtttgcta aaatcatagt ttcttaacaa ttcaacaatc tccgtgatgg
    12721 agaaggcctt ctctgccggc atcagctcgc gacgttgcaa aggtatcggc gaatgaaggc
    12781 tgatagccag atggcagtcc gactcctcaa taaaacgctg caagcccttc ttcaatccca
    12841 cagaagaaag tgtaacacgc ttgggactcc acgcataccc atatgaggcg gtcattattt
    12901 ccagcgcttt caatacctcg tccagattat caagtggttc acccatgccc atcattacca
    12961 cattggtaag cttgtccctt tcgggcaacg aattgatttg attaataatc tggttggatg
    13021 tcagattggc agtaaaacct tgtttgccgg tcatacagaa cttgcaattc atcttacagc
    13081 ccacctgcga ggagacacaa agcgtagccc tgtcttcgtc gggtatatag acagcttcca
    13141 cgaaatgccc ctctcctgcc cgatacaagt atttcaccgt accgtctaca gagcgcatgg
    13201 catctaccgg tgcttcggca cctacctcat agatttcttt cagcaattcc cgatgcttta
    13261 acgaaagatt gctcatttcg tctatagaag tcaccttctt gccatacagc caggaagcta
    13321 tctgcttggc agagaaaccg ggcattccca gattcttcac cacattctgc aattcagaga
    13381 gcgtcaagcc caatagaggt cgtttctgca tatcgttttt cattaaaaac aaaactcttt
    13441 caagaatgca aaggtaggaa taaagttgca caaagacaac ggagagtata gaaaatgaaa
    13501 tgtacagaga atgaaaaagc cgcccgggag taccggacgg cttttcaata tgggttttct
    13561 attcttagaa gaataaataa cgttggtctt ttacgttggc tttcagatac aagtcactga
    13621 tgaactggct tgccatgcgt gcgtgcatgt tagccaagtt agcctcttca gtttccttgt
    13681 tgaatgtttc gttcaatttc tcttttgcat aaggttgcag aacgaataca ccaccattac
    13741 ccttgatagg agcactcagc ttgttcactt cggcaataga agcgtatgcg cctaccagag
    13801 gttcgctgct acgcaatgcc gggatatagg caggagcaga gaaagtaacg tgctttacag
    13861 aatcactgac agcatttgcc atattcttgt actgctcgaa cgaagttgca ttggcagcct
    13921 tcatatcagc cataatcttc tctgctttct tgtcacggag aatttcagct ctcaactggt
    13981 cctttaccaa agccagtggg cgataacctt caggaacaat acttgcaaca cctactacca
    14041 gcatacggtc gctctcgcca cattcgtaca aaccggaaac ttcaccggcc tttgcctcaa
    14101 acgcccattt caaagcatct ttggtacctc tgataccacc gataccatgt tcagagctgt
    14161 acaagtcggc tctatccaac aacttataac cggcatcttc cgcattggca atcattttct
    14221 ctaaagtatt gtttgcagcg ataaactggc tgaattcatt gtatgccttg ctgtaagttt
    14281 ccttactgaa ttctaccgga cgcttgataa cggctacctt atatttatcc ttgacagcct
    14341 tcttgttggt tacctgcaaa atgacatttg cttgtcccaa cgccagattg gtcagttcgt
    14401 tctgtcccaa agtagtgaca gcagtaatat atttcaagtt gtcaccgtca atctgtgcgc
    14461 cttcgtagtt agctgaagag atccaggtag gctcaccggt ctgaccgtac ttcttcgcaa
    14521 tttcagcaaa gctggcacca cccttaatag cattgtagat gctgtcggct aaagtcttcg
    14581 tcttttcagc atcttcggca actacctgaa tctgacggaa ctcgatagag tccggcatag
    14641 cagcagtagc caatttcttg aaagagttaa gagtattgtc cgatacgtta taataaggtc
    14701 cgaatacacc acccaccgca acagagtcca aacgggctgt cacatcagca ggcagagact
    14761 tagtagtgta gaacaagtct gtataaggag cttcggaacc ggtagaacgg ataaaggtag
    14821 tatagtcaga aggattggca gtaagttgtt cagtgtattc ttccatttcc ttctggagag
    14881 cagctctgtc ttctgcactt gcagtaactt gcacatcaat gaacttgata ttgcgagttt
    14941 ccacatattg cttgaactgt tctttcttct tgtcgtatgc agccttcaaa tcagaatcct
    15001 tgataacgat ggtagagtca acgatagaag aatagggaac tgcagcaagc agcaggtctg
    15061 actgctctac tcttgcatca aaagcgtcct gagcttctac cgggttggag aaaagggatt
    15121 ttgtaatcaa agcttgatac ttctcctgaa gacgtgcctg gataagggac ttttcgagga
    15181 aagaccagaa cttgtacatg gattcatagt attctgcata ttgtgaaggc atctgtgcct
    15241 tattcatttt tgaatagtcc accaagaact tcttcaacat atccttatca aacgcaccgg
    15301 tctgaggatt acggaacgga gtctgttgca gcatcggatg cacaccggca ttaatgatag
    15361 cctgaatctc agccttcgat acaaccagac cgagtttctt tgcttccttt tcaatcagct
    15421 tattattgac gtatgttctc catacttcat ctttgatttg gtttgtctgc tcatcgctca
    15481 atgcactgtt gccact
//
