LOCUS       c00119_gnlPro..        13699 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FMEFAMOC_119.
ACCESSION   c00119_gnlPro..
VERSION     c00119_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 18:43:47
            Original ID  :: gnl|Prokka|FMEFAMOC_119
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13699
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1221
                     /locus_tag="ctg119_1"
                     /transl_table=11
                     /translation="LLLLMVEAVLIPAFAQMPEIKLGQSISFEEYLNRVAKKNLSYLAE
                     KLNVSIADAEVIARKIFPDPELEFEAGNETFSLGVSYSLEMGNKRGARIKLARTQAELE
                     KLVLQQGFQDLRAEAADLFLEAILQRELLEVQKSSYEYMYQLSQSDSLRYVSGEITEND
                     VRQSKLEAVTLLNTVYSQEAAYHSALVLLNKHMGMSADTLHIPLGNWEELSRDFALSDL
                     VKAGLDNRIDLLVAQKSTEVTTREYKLTRAERRPDIGVSVSYERNWNGFLPPSRSATAG
                     VSVPLTFSNINKGAVKAAKFRIAQSEIMERDMELQIQAEITQAWFNYEAEKKKIAQYKA
                     GVLEDSQKVLDGMVYKYKRGETSILDVLVAQRTYNEVQQEYLETMKGYAASLVALESAC
                     GIWDICF"
     protocluster    1..13699
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4989:9846]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4990..9846
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..13699
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13699
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             1557..2324
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg119_2"
                     /sec_met_domain="Acetyltransf_1 (E-value: 3.5e-08,
                     bitscore: 23.4, seeds: 223, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAKYITLTKENIEKEHICCAFSDKKCKDSYELKKTWLKNEFENG
                     YVFRRLDERAKVFIEYGPAEKAWVPVNAPNYLMINCFWVSGKYKGCGHGKALLQSAVED
                     AKAQGRDGLVTVVGTSKFHFMGDAKWLLRQGFETIEKLPYGFSLLALKINPAAPDPSFN
                     GTVSSGECEEKEGVVVYYTHRCPFAEFHVRNSLVGVTENKGIPLKIVRLETMAQAQNAP
                     TPATIFSLFYKGKFVTTDLSACMEQRFDKALGL"
     CDS             2703..4472
                     /locus_tag="ctg119_3"
                     /transl_table=11
                     /translation="MKSIRSVICFCLFLFVFNQLLFADKTIENDSLYTSEYISRIYMAE
                     PERALSLLDGAESKKTIPLRIIHELRSRVYRNMYMTKLAFLYAKKSYLLDSVSQKDPKH
                     LLTMTVDLAELAVLMSDHKESMRYALDGIKLAQKEKDKGAESKLLFCIGENKWQLSFKE
                     EAYDYFDKAIKLLQGTSSKLEMTMLSYFYGMKMDYLLNDSRSKEALEVGLKREKLLKDI
                     AKLPEKTKGFLDLQYTYLYAKMSYICYLEGKYDQAEKYYQQYLSTENSQTPDGKTYAIP
                     YLLVSKQYQKVVDQCQDFKKLMQEQDTVNLQYISILQKEVKAYKGLKDFEKVAALRESI
                     ISIIDGINSKDKQNAALELNAIHKADEQEEYIAEQTLQLRIRNISLAFLGCVTCLILFV
                     LWRIWRHTIIVKYKNKMLAKFINEKLAGKVENKQLFIDGDAEDPIAVPLDLEPETGFSE
                     KDDLSPDEVVESREEEDENKKIFKELNRIVVQDQLYLSPELSREDLAQIVHLNNARFAR
                     MIKENTGTNFNGYINELRINYAIQLLKQHPNYTIRAIADEAGFNSTPILYSMFKKKTGM
                     TPYEFKKTQESLG"
     CDS             4543..4905
                     /locus_tag="ctg119_4"
                     /transl_table=11
                     /translation="MVQVRIKRVYEDFSETDGYRVLVDKLWPRGIKKEWLKYDYWAKDI
                     TPSAALRRWFHEDIPGHWNDFVVMYQKELEASQAVADFLTLIKPHPVITLLYASKEPVY
                     NHARILRDYLEMHLKE"
     CDS             4990..6222
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg119_5"
                     /sec_met_domain="HBT (E-value: 2.1e-17, bitscore: 53.0,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKSLELGNYGGYILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNN
                     FALFTYHDDTIITDTPENEHIQNEARLNNLKVIKEEEFSVAIDFAPCKCMLVSDDEEAL
                     VSLEGHWKRRLNGALDVFRSEPYFLEVVPCAIDKANTLGALLEELDVKREEVIAIGDGV
                     CDVTMIQLAGLGVAMGHSQDSVKVCADYVTASNEEDGVALAVEKAIIAEVRAAEIPLDQ
                     LNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALGETVAGLGS
                     MILCQPDEIVVGMQVSGNHISSAHEGDTVRAVATIVHKGRSSHVWNVDVFTSTNKLVSS
                     IRVVNSVMKKR"
     CDS             6219..7331
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg119_6"
                     /sec_met_domain="Chorismate_bind (E-value: 3.2e-58,
                     bitscore: 186.9, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDEKSNLTTIDALIQRKQPFAVYRVPGEKYPRLLTEDVGAVRLI
                     FDLKELNGQRGFVIAPFRIDKSCPIVLIQSDRTGQPLPMEIVAEEEQDLQSYPEESFHT
                     LCTGKYATCFHTFIEALRDATFDKLVLSRSLTIGKNPEFSPSAVFRAACQRYIHSYIYL
                     CYTPQTGVWLGSTPEIILSGEKNEWNTVALAGTQPLQNGKLPQVWDDKNRQEQDYVASY
                     IRRQLLSLGIRSTESGPYPAYAGALSHLKTDFHFSLKDNKNLGDLLKVLHPTPAVCGLP
                     KEEAYRFILENEGYDRKYYSGFIGWLDPEGRTDLYVNLRCMHIEDEQLTLYAGGGLLAS
                     SELNDEWQETEKKLQTMRRILVSAPIMMNH"
     CDS             7351..9018
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg119_7"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.8e-09, bitscore:
                     25.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLEAHGITKVVLCPGSRNAPIVHTLSTHPGFT
                     CYAMTDERSAGYFAIGLALNGGHPAAVCCTSGTALLNLHPAVAEAYYQNIPLVVISADR
                     PAAWIGQMAGQTLPQPGVFQTLVKKSVNLPEIQTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINIPISEPLFQFTVESLPEVRVITRYQGLNVYDRDYNDLIERLNRYQKRMIIVGQMN
                     LIYLFEKRHTKLLYKHFVWLTEHIGNQTVPGIPVKNFDAALYAMPEEKTGQMTPELLIT
                     YGGHVVSKRLKKYLRQHPPKEHWHVSADGEVVDLYGSLTTVIEMDPFEFLEKIAPLLDN
                     RVPEYPRVWENYCKTIPEPEFGYSEMSAIGALIKALPESCALHLANSSVIRYAQLYQVP
                     STIEVCCNRGTSGIEGSLSTAVGYAAGSDKLNFIVIGDLSFFYDMNALWNINVRPNLRI
                     LLLNNGGGEIFHTLPGLDMSGTSHKYITAVHKTSAKGWAEERGFLYQRVENEEQLAEAM
                     KTFTQPEAMEQPVLMEVFSNKNKDARILKDYYHQLKQK"
     CDS             9022..9846
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg119_8"
                     /sec_met_domain="ECH_1 (E-value: 2.1e-82, bitscore: 265.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYEDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKKYPKFP"
     CDS             9850..10875
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg119_9"
                     /sec_met_domain="MR_MLE_C (E-value: 4.4e-30, bitscore:
                     94.5, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDCKIDIIPRVLHFKQPAGTSRGTYTTRKVWYLHFTAPEFPNWVG
                     IGECAPLPNLSCDDLPDYEEVLAKICRQVENQGGKLDMEALCKYPSILFGLETAIRHFF
                     EGSWALWDTPFSRGEAGIPINGLIWMGDFNRMLAQIEKKMEAGFRCIKLKIGAINFEEE
                     LALLQHIRSHYSSKEIELRVDANGAFSPTDAMEKLKRLSELDLHSIEQPIRAGQWEEMA
                     RLTSESPLPIALDEELIGYNTWEEKQRLLSAIRPQYIIIKPSLHGGLAGGEEWIAEAEK
                     LNIGWWITSALESNIGLNAIAQWCATFQNPLPQGLGTGLLFTDNVEMPLEIRKDCLWFC
                     K"
     CDS             10872..11978
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 52.9; E-value:
                     7.6e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg119_10"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-17, bitscore:
                     52.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMIFDRQKQRLLLEGKEYTPGDIHSLVAEGEGNHPSAIWDLYLFL
                     NEWFNDDPVITVHTSGSTGAPKELLVRKDQMIQSARLTCEFLDLKQGETALLCMNLRYI
                     GAMMVVVRSLIAGLNLIVRRASGHPLADVDTPLRFAAMVPLQVYNTFQIPEEKEKLKQT
                     EILIIGGGAVDKALEEKIRNLSNAVYSTYGMTETLSHIALRRLNGAAASDRYYPFSSVE
                     LFLSSENTLMINAPLVCDDTLQTNDIARIYPDGSFTILGRKDNVINSGGIKVQAEEIER
                     LLQSSIPVPFVITSVPDRRLGQAVTLLIEGQMEISALGTKLESVLASYYRPKYIYTVNH
                     IPQTGNGKINRKECRVLAESLQLLGRQE"
     CDS             complement(11952..12521)
                     /locus_tag="ctg119_11"
                     /transl_table=11
                     /translation="MKISFSRQTKERAFKQLYEDYYAPFCLYAKRFVDDKEVREDIVSD
                     VFTSLWDKLDTDSFDLQSETALGYIKMCVKNSCLNFLKHQEYEWSYAENIQKKAPLYET
                     ETDSVYTLDELYRMLYETLNKLPENYRTVFMKSFFEGKTHAEIAEEMNLSVKSINRYKQ
                     KTMELLRNELKDYLPLFLLFLSPEQL"
     CDS             12746..13669
                     /locus_tag="ctg119_12"
                     /transl_table=11
                     /translation="MENMNPESLLRKAQALGEDIKEMESIDVMGAYQQAQTQIKTNRRR
                     SMYNQLMRYAAFLTIPLLLSSLILGYLYWGATDTEEKYAEVMAATGSVIRYELPDHSVV
                     WLNSGSTLRYPTVFKKDNRNVELKGEAYFEVEADRKRPFYVNTPAGLSVYVYGTKFNVN
                     AYEDDNSIETVLEKGKVNVISPDGKTTVQLAPGERLLYNKVDQKLLKGKVDVYEKVAWK
                     DGKLIFRNAELGEIFKRLARHFNVDIQFNNISGKEYKYRATFRNETLPQILDYLAKSAA
                     LKWRTEEAVQQADDTFTKKKIIVDLY"
ORIGIN
        1 ctcttgctgt taatggtgga agccgtactc attccggctt ttgcgcaaat gcctgaaata
       61 aagctggggc agtctatttc tttcgaagaa tatctgaatc gggtagcgaa aaagaacctg
      121 agttatttag ccgaaaaact caatgtgagt attgctgatg cggaagtaat tgcccggaaa
      181 atctttccgg atccggagtt ggaatttgaa gcaggtaatg agactttctc gttgggagtt
      241 tcctattcat tagaaatggg aaataaaagg ggagcacgta ttaagttggc gcggactcag
      301 gcagaattgg agaaactggt cctgcaacag ggctttcagg atttgagggc ggaggctgcc
      361 gacctttttc tagaagcaat tcttcagcgc gaattacttg aagtacagaa aagttcttat
      421 gagtatatgt atcagctgag tcagtcagat agtttacgtt atgtttcggg agagattacg
      481 gagaatgatg tccggcagtc aaaactggaa gctgtcacct tgcttaatac tgtttacagt
      541 caggaggcgg cttatcattc cgctttggtt ttgttgaata aacacatggg gatgagtgct
      601 gatacgcttc atatcccttt gggaaattgg gaagagctaa gcagggactt tgctctgtct
      661 gatttggtca aagcgggact ggataatcgc atcgacctgc ttgttgctca aaaaagtact
      721 gaagttacta cccgggaata taaactgacg agagcggaac gcagacccga tatcggagta
      781 tctgtttctt atgaaagaaa ctggaacggc tttcttcctc cgtcccgttc tgctactgcc
      841 ggtgtatctg ttcctctgac attctcgaat ataaataaag gagctgtaaa agctgcaaag
      901 tttcggattg cccaatcgga gataatggaa agagatatgg aattgcagat acaggcagag
      961 ataacccagg cctggttcaa ctatgaggct gaaaagaaaa agatagctca atataaagcc
     1021 ggtgtacttg aagactcgca gaaggtgctc gacggaatgg tatataaata caaacgggga
     1081 gaaacgagta ttcttgatgt actggttgcc cagcgtactt ataatgaagt gcaacaggag
     1141 tatctggaaa caatgaaagg atatgccgct tcactagtag cattggaaag tgcttgtggt
     1201 atatgggata tatgctttta acagttaaat atccggcttt actattgtga attgcagcaa
     1261 agccggatat ttgtatggtt accagtcagc ggtttcacgc tttatgttaa atcattgtgc
     1321 gatattcctc ctgttttttc ttagggagtt ttttgatcac ttcttccaca gagtggtcaa
     1381 taagttcttt gataagtttg tcactcaggt ttatttactt atctgttttc cgaactttaa
     1441 tccgtactac tgtgtcattt tgacgagact ggacaatgtt ttattacttt cgattgtgta
     1501 tctttgctgt agttaaaatg gacaaccgga atttatatac taataaacag aatattatgg
     1561 aagcgaagta tatcactctg actaaagaga atatcgaaaa agaacatatt tgctgtgctt
     1621 tctccgataa gaaatgcaag gatagctatg agttgaaaaa gacatggctg aaaaatgagt
     1681 ttgagaatgg ctatgttttc agacggcttg acgaacgtgc aaaagtattt atagaatatg
     1741 ggcctgccga aaaagcttgg gttccggtta atgcacctaa ctatttaatg ataaactgtt
     1801 tttgggtttc aggaaaatat aaaggatgcg ggcatggcaa agcactatta cagtctgctg
     1861 tcgaggatgc caaagcacag ggtagggatg gcttggtgac tgtggtcggt acctctaaat
     1921 ttcattttat gggtgatgcg aaatggttat tacgtcaggg gtttgagacg atagaaaaac
     1981 taccctatgg tttcagtctt ttggctttga agataaatcc ggcagctcct gatccgtcat
     2041 tcaatggaac agtatcaagt ggagaatgtg aggaaaaaga aggtgtagtc gtttattata
     2101 cacatcgttg tccgtttgca gagtttcatg tccgtaattc tttagtgggt gtgactgaga
     2161 acaaaggtat tccattgaag atagtcagat tggaaacgat ggcacaagca caaaatgcac
     2221 ctacacctgc tactatcttt tctcttttct ataaaggaaa gtttgtaacg acggatttga
     2281 gtgcatgtat ggagcaacgg tttgataaag cgttgggatt ataatctttc ttattacagt
     2341 atgtgtttct cttttttgat tttctgtttt tgtgctgttt tgctctgatg agtgtggcgg
     2401 gttaataatt gtctggtgtt tatttagact ggtcggttcg atttttcatg tgctgctctg
     2461 atcttatgca gattccttaa tagaatcggc agtttatttg tatgttgaga tgttttgttt
     2521 tatgtatgtg acatatgctt gatttttagt attttattgt atgtggttgg tggggaagac
     2581 ttgatggctc ttgactttta taatcactaa cttttcttat tttagttcat ttaaatatgt
     2641 tcaattcttg cattttatga aactatgttt tacttttggg gagtaaagtc attgggatta
     2701 taatgaaaag tattcgctcg gttatttgtt tttgtttgtt tttgtttgtg tttaaccagc
     2761 tccttttcgc cgacaaaact atagagaatg attcgctata taccagtgag tatataagtc
     2821 gaatttatat ggcagaacct gaacgggctt taagtttgtt ggatggagct gaaagtaaga
     2881 agactatccc tctgcgtatt atacatgaat tacgcagcag ggtttatcgt aatatgtata
     2941 tgactaaact ggcttttttg tatgccaaaa agtcttattt gctggattcc gtttctcaga
     3001 aagatcctaa gcacttgttg accatgactg tcgacctggc agaattagca gtgcttatga
     3061 gtgaccataa agagagtatg aggtatgctc ttgatggtat caagctagca caaaaagaaa
     3121 aggataaagg ggctgaaagt aagctgttgt tttgcattgg tgaaaataaa tggcaattgt
     3181 ctttcaaaga ggaggcatat gactattttg acaaagctat caaattgctt caaggtacaa
     3241 gttccaaatt ggaaatgact atgctttcat acttttatgg gatgaaaatg gattatctgc
     3301 tcaatgattc ccgtagtaaa gaagcattgg aggttgggtt gaagcgcgaa aagctactta
     3361 aagatatagc taaattaccg gaaaaaacaa aaggctttct tgatctgcaa tatacttact
     3421 tgtatgcaaa aatgtcgtat atctgctatc tggaaggaaa gtatgatcag gcggaaaaat
     3481 attatcaaca atatttgtca acagagaatt cacagacacc ggatggaaaa acctatgcga
     3541 taccttatct gctagtgtct aaacaatatc agaaagtcgt tgatcaatgt caggatttta
     3601 agaaattgat gcaagagcag gatactgtca acttgcagta tattagtatc cttcagaaag
     3661 aggtgaaagc ttataaaggc ttgaaggatt ttgaaaaagt agcagcatta cgtgagtcta
     3721 ttatttctat tattgatggt attaacagca aggataagca gaatgcggct ttggaattaa
     3781 atgctattca taaagctgac gagcaggaag aatatattgc cgaacagact ttacagttaa
     3841 gaatcagaaa catatcactt gcttttttgg gatgtgtcac ttgtctcatt ttatttgtgc
     3901 tatggcggat ttggcgtcat acgattattg ttaaatataa aaacaaaatg ctggcaaagt
     3961 ttatcaatga gaaactggct ggaaaagtag agaacaaaca attattcata gatggagatg
     4021 cggaagatcc gatagctgtt ccattggact tggaaccgga aactggcttt tccgaaaaag
     4081 acgatttatc tccggatgaa gtagtggaga gtagggagga agaggatgag aataagaaaa
     4141 ttttcaaaga actgaatcgt attgttgttc aggatcagtt atatctgtct ccggaattgt
     4201 cgagagagga tctggctcag attgtacatt tgaataatgc gcgtttcgcc cggatgatca
     4261 aggaaaacac cggaactaat ttcaacgggt atattaatga acttcgtatt aactatgcga
     4321 ttcagttatt gaagcaacat cccaattata ccattcgtgc gatagctgat gaagccggat
     4381 ttaatagtac gcctattctg tacagtatgt tcaagaaaaa gactggtatg actccttacg
     4441 aatttaaaaa aacgcaggaa tccttaggtt gattttggct ttttcgataa acaattttcc
     4501 gttttatcgg tttattctta tgataactaa atataaacgg aaatggtgca agttaggata
     4561 aagcgagtgt acgaagactt ttcagagacc gacggatatc gggtgctggt agataaactc
     4621 tggccacgtg gaatcaaaaa agaatggttg aaatatgatt actgggcaaa agatataacg
     4681 ccttccgcag cactgcgcag atggtttcat gaagatattc cgggtcactg gaatgatttt
     4741 gtcgtaatgt atcagaagga actggaagct tctcaagctg ttgccgattt tctgactctt
     4801 atcaaacctc atccggtgat cactttgctt tatgcatcca aagaaccggt ttataatcat
     4861 gcccgaatcc ttcgtgatta tttggaaatg catctgaaag agtgaaatta aagtaatttt
     4921 tatctctttc cgctttcagt cgttcactca atttcctacc tttgtaatct aaatcaaaat
     4981 cgtgtgtcca tgaagtataa attattagtt cttgatgtag acggaacgct tctcaatgat
     5041 gcaaaagaaa ttagtaaacg tacattggct gctttgctga aagttcagca gatgggagta
     5101 cgtatcgtgt tggcatccgg ccgaccgact tacggtctga tgcctttagc caaatcccta
     5161 gaactcggaa attatggagg ttatatcctt tcttataatg gttgccagat aattaatgct
     5221 caaaacggag aaatactgtt tgagcggagg attaatccgg aaatgttgcc ttatctggaa
     5281 aagaaggcaa gaaaaaataa tttcgcactg ttcacttacc atgatgatac gatcattact
     5341 gacactccgg agaatgaaca tatccagaat gaagctcgct tgaataattt gaaagtgatc
     5401 aaggaagagg aattttctgt agcaattgac tttgctccgt gtaagtgtat gcttgtcagc
     5461 gatgacgagg aagcgttggt tagtctggaa ggacactgga agagacggtt gaacggagct
     5521 ttggatgttt tccgttccga accttatttt ctggaagtag tgccgtgtgc gattgataaa
     5581 gccaacacat tgggagcttt attggaagaa ctggatgtga agcgtgaaga agtcatcgct
     5641 ataggagacg gtgtgtgcga tgtaacgatg attcagctgg caggactggg agtggcgatg
     5701 gggcattcgc aggattcggt aaaggtctgt gcggattatg tgacagcttc caatgaggaa
     5761 gacggagtgg ctctggctgt cgaaaaggcg ataatagcgg aagttcgcgc tgcagagatt
     5821 cctttggacc agttgaatgc acaggcgcgt cacgcattga tgggtaatct gggtatccaa
     5881 tatacatatg ccgacgaaga ccgtgtagag gcgacgatgc cggtagatca ccgtacccgt
     5941 cagccgttcg gtattttgca cggtggagct acgcttgcat tgggagaaac agttgccgga
     6001 ctcggctcga tgattctctg tcagccggat gaaattgtgg taggaatgca ggtcagcgga
     6061 aatcatatat cttctgcgca cgaaggtgat acagtacgtg cagtagcgac gattgtacac
     6121 aaaggacgtt cctcccatgt atggaatgtg gacgttttta cttcaaccaa taaactggtg
     6181 tcctctatac gggtggtcaa cagtgtgatg aaaaaaagat gattgacgaa aaaagtaact
     6241 tgacaactat tgatgcactt attcagcgga aacagccctt tgctgtttat cgtgttcccg
     6301 gggagaagta tcctcgtctg ttgacagaag atgtcggagc tgtccgcttg attttcgatt
     6361 tgaaagaact gaatggacaa agaggatttg tgattgctcc gttccgtata gataagtcat
     6421 gtccgattgt gttgatacag tccgacagga ctggacaacc gttgcctatg gaaatcgtgg
     6481 cagaggaaga gcaggacttg caaagttatc cggaggaatc ttttcatacc ctttgtactg
     6541 ggaagtatgc gacctgtttt catacattta ttgaagcctt gcgtgatgct acctttgata
     6601 aactggtgct ttcccgtagt ctcactattg gaaagaatcc ggagttttcc ccttcagctg
     6661 tttttcgtgc agcttgtcaa cgttatattc attcctatat ctatctgtgt tatactcctc
     6721 agacgggcgt gtggctggga agtacccccg aaattatatt gtcgggcgaa aaaaatgaat
     6781 ggaacacagt tgccctggca ggaactcaac ctttgcagaa tggtaaactt ccgcaagtat
     6841 gggatgacaa aaaccgtcag gagcaggatt atgtggcgtc ctatatccgt cggcagcttc
     6901 tttcgctggg cattcgctcc acagagagcg gaccttatcc ggcttatgcc ggtgccttgt
     6961 cacatctgaa aactgatttc catttctctt tgaaagataa taaaaatctg ggagaccttc
     7021 tgaaagtcct gcatccgact cctgccgtgt gcggactgcc taaagaagaa gcctaccggt
     7081 tcattttgga aaatgaaggg tacgatcgta agtattattc cggttttatc ggttggctcg
     7141 atccggaggg acgcacagat ttgtatgtga atctgcgttg catgcacatt gaagacgagc
     7201 aattgacact gtatgccggt ggcggattgt tagcctcttc agagttgaat gatgaatggc
     7261 aggaaacgga aaagaaattg cagaccatga ggcgtattct tgtgtctgct ccaataatga
     7321 tgaatcacta acaagctaat cactatcaat atgtattcgg acaagaaaaa tatactccag
     7381 ttggtcgcgc tgcttgaggc gcatggaatt acgaaagtag tgttatgtcc cggtagccgt
     7441 aatgcaccta ttgtgcatac gctgtctact catccgggtt ttacttgtta tgctatgacg
     7501 gatgaacgga gtgccggtta ttttgcgatt ggtcttgcgc tgaatggcgg gcatcctgct
     7561 gccgtttgct gtacttccgg tacagcgttg ctcaatcttc atcctgctgt ggcagaagcg
     7621 tattatcaga atataccttt agttgttatc tctgccgatc ggcctgctgc ctggattgga
     7681 cagatggcgg gacagacatt gccgcagccc ggtgtttttc agacattggt gaagaagtcg
     7741 gtaaaccttc cggagattca gacagaagag gatgaatggt actgtaaccg cttggtgaat
     7801 gaagccttgc tggaaaccaa ccatcatgga aaaggtccgg tacatattaa tattcctata
     7861 tccgaacctt tgttccagtt tacggtggag tcgcttcccg aagtacgtgt cattacgcgc
     7921 tatcaggggc tgaatgtata cgaccgggat tacaatgacc tgatcgaacg cttgaacaga
     7981 tatcagaagc ggatgattat tgtcggacag atgaacttga tttacttgtt tgagaaacgg
     8041 cataccaaat tgttatataa acatttcgtg tggctgaccg agcatatcgg taatcagaca
     8101 gtacccggta ttccagtgaa gaattttgat gcggcgcttt atgcgatgcc cgaagagaaa
     8161 accggccaga tgactcccga gttattgatt acttatggcg gacatgtggt ttccaagcgg
     8221 ttgaaaaaat atcttcggca gcatccgcct aaagaacatt ggcatgtgtc tgctgatgga
     8281 gaagtggttg acctttacgg ttctctgact accgtcatcg aaatggaccc gtttgagttt
     8341 ctggagaaaa tagctccatt gctggataac cgcgtgccgg agtatccccg tgtatgggag
     8401 aattattgca agaccattcc cgaaccggag ttcggatatt cggaaatgtc ggctatcggt
     8461 gctttgataa aagcattgcc ggaatcatgt gcattgcatc tggcaaatag ttctgttatc
     8521 cgctatgctc agttatacca ggttccttct acgattgagg tatgctgtaa tcggggtaca
     8581 agcggcatcg aaggctcgtt gtccacggca gtgggatatg ccgccggttc ggataaacta
     8641 aattttatag ttataggtga ccttagtttc ttttatgata tgaatgcttt gtggaacatc
     8701 aatgtccgtc ccaatctacg cattcttttg ctgaataacg gaggagggga gattttccat
     8761 acattacccg gactggatat gtcgggtaca tcgcacaagt atattacagc cgttcacaag
     8821 acatctgcca aaggatgggc ggaagaacgc ggattccttt atcaacgggt agagaatgaa
     8881 gaacagcttg ccgaagcgat gaaaaccttc acacaaccgg aagccatgga acaaccggtt
     8941 ctgatggaag tattcagcaa taaaaataaa gatgcacgta tactgaaaga ttattatcat
     9001 caactaaaac aaaaatagat tatgtcaaca caaagagaat ggacaaccat cagagaatac
     9061 gaagatatcc tctttgatta ctataatggg attgcccgca tcaccattaa ccgtgaacgc
     9121 tatcgaaatg catttactcc gactacaacg gctgaaatga gtgacgcatt gcgcatttgc
     9181 cgggaagaag cggatattga tgtgatcgtg attacgggag ctggtgacaa ggctttctgt
     9241 tcgggcggtg accagaatgt gaaagggcgt ggcggctata tcggcaagga cggtgttccc
     9301 cgtctgagtg ttctggatgt acagaaacaa atccgcagca ttccgaaacc ggtaattgct
     9361 gccgtaaatg gatttgccat tggtggcgga cacgtgcttc atgtagtttg cgatttatcg
     9421 attgcttcgg agaatgcgat cttcggacag accggtcctc gcgtaggtag ctttgatgca
     9481 ggtttcggag cctcttatct ggctcgtgtc gtcggtcaga agaaggcacg tgagatatgg
     9541 ttcctttgcc ggaaatacaa tgcgcaggaa gcgttggata tgggattggt gaataaagta
     9601 gttccattgg agcaactgga ggatgagtat gtgcaatggg cggaagaaat gatgctgctc
     9661 agtccgttgg ccttgcggat gattaaagcc ggattgaatg ccgaactgga cggccaggca
     9721 ggtattcagg agctggcagg ggatgcgacc ttgctttact atctgacgga tgaggctcag
     9781 gaaggaaaga atgcatttct ggagaaacgt aaacctaact ttaagaaata tccgaagttc
     9841 ccttaaacaa tggattgcaa aatagacatt attccgcggg tgcttcattt caagcagccg
     9901 gccggaactt cacgaggcac atacacaacg cgaaaagtct ggtatcttca ttttactgct
     9961 cccgaatttc ccaattgggt agggatcggg gagtgcgctc ctctgccaaa tcttagctgt
    10021 gatgatcttc ccgattacga ggaagtgctg gctaaaatct gccggcaggt agagaatcag
    10081 ggaggtaagc tggacatgga agctctatgc aagtaccctt ccatcctttt tggcttggag
    10141 acagccattc gtcacttttt tgaaggaagc tgggctttgt gggatacacc cttctcacgt
    10201 ggggaagcag gtattccgat aaacgggctt atctggatgg gtgacttcaa tagaatgctt
    10261 gctcagatag agaagaagat ggaggcggga ttccgctgta taaagttgaa gatcggtgcc
    10321 atcaactttg aagaagaact ggctttactc caacatatcc gctctcacta ttcttctaaa
    10381 gaaatagaat tgcgtgtaga tgccaacgga gcattctcac caacagatgc gatggagaaa
    10441 ttgaaacgct tgtccgaact ggacttacat tcgatagaac agcccattcg tgccggacaa
    10501 tgggaagaaa tggcacgtct tacttccgaa tctcctttgc cgatagcttt ggatgaggaa
    10561 ctgataggct ataatacctg ggaagaaaag caaagattac tttcggctat ccgtccgcaa
    10621 tatattatta tcaaaccttc tcttcatggc ggattagccg gtggcgagga gtggattgca
    10681 gaagcggaga aactgaatat cggttggtgg ataacttctg ctctggagtc taatatcggt
    10741 ctgaatgcta tcgctcaatg gtgtgctact tttcagaatc cattgccgca agggttaggc
    10801 accgggttac tctttacaga taatgtagag atgcctcttg aaatcagaaa agattgtttg
    10861 tggttttgta aatgatgata ttcgaccgac aaaaacagcg tttgttgctg gagggaaagg
    10921 aatatactcc gggcgatata catagccttg tagcagaagg tgagggaaac cacccttctg
    10981 ctatatggga cttgtatctt tttctaaacg aatggtttaa tgatgatcct gtgatcactg
    11041 tacatacttc cggttctacg ggggcaccta aagaattgct tgttcgcaaa gatcagatga
    11101 tacagagtgc acgcctgact tgtgagtttc tggatttaaa gcagggtgaa acggcattat
    11161 tgtgtatgaa ccttcgctat atcggggcga tgatggtagt cgtccgttct ttgattgccg
    11221 ggttgaatct tatagtacgt cgggcttccg gtcatccatt ggcagatgtg gacactcctt
    11281 taaggtttgc ggctatggtg cctttgcagg tgtataatac atttcagata cccgaagaga
    11341 aagagaaatt aaagcaaacg gagattttaa ttataggagg cggagcagtt gacaaggctt
    11401 tagaggaaaa aatcagaaat ctgtccaatg ctgtttattc aacttacggg atgacggaaa
    11461 ccctttctca catcgctctt cgccgtctga atggcgcagc agcatccgat cgttattatc
    11521 ctttttcatc cgtagagttg tttttgtctt cagaaaatac tttgatgatt aatgctccgc
    11581 ttgtttgcga tgatactctg cagacaaatg atattgcccg catttatccg gacggtagtt
    11641 ttacgattct gggaagaaag gataatgtaa tcaatagcgg aggaattaaa gtgcaggcag
    11701 aagagatcga aaggttactt cagtcgtcta tccctgtacc gtttgtgatc acttccgttc
    11761 cggatcggcg tttggggcag gctgttactt tattgataga agggcagatg gagataagtg
    11821 cgctagggac taaattggaa tcagtcttag catcttatta tcgtcctaaa tatatttata
    11881 cggtaaatca tattcctcaa acgggaaatg ggaagattaa tcgtaaagag tgccgtgttt
    11941 tagcagagag cttacagttg ctcgggagac aggaataata aaaacagcgg gaggtaatct
    12001 ttcaactcgt tccgcaggag ttccattgtt ttttgtttat accgattaat ggattttacg
    12061 ctgagattca tttcttcggc aatttccgca tgtgttttgc cttcaaagaa acttttcata
    12121 aatacggtgc gatagttttc cggaagctta tttaatgttt cgtatagcat tcggtataac
    12181 tcatcaagtg tatatacact atctgtttct gtttcatata gaggagcttt cttttggata
    12241 ttttcggcat aactccattc atactcctga tgtttcagaa agttcaaaca gctgtttttt
    12301 acacacattt ttatatatcc caatgctgtc tctgattgca aatcgaaaga gtcggtatcc
    12361 aacttgtccc atagggaggt gaatacatcc gaaacaatgt cctcgcggac ttctttatca
    12421 tctacaaatc tttttgcata caggcagaaa ggggcataat aatcctcgta aagttgtttg
    12481 aaagctcttt ctttagtctg tctggaaaaa gatattttca ttattttgag attctgtagt
    12541 ttttcatttt acttcaaata tataataaga aaatcagcat ttcctaaaat tttctttctt
    12601 ttttcgtttt tggtatgaag ctgtggaaaa taagatagct taaaaaataa aataaaaaaa
    12661 agtatgttat acctgtccct tttcgattac ctcagttgta ctattagtgt aattgcaatt
    12721 aaaagataag attttgaaag agaatatgga aaatatgaat ccggaatcat tgctccgaaa
    12781 agcgcaggca ttaggagagg atattaagga aatggagtct attgatgtaa tgggtgccta
    12841 tcaacaagca cagacccaaa taaagacaaa cagaagaagg agtatgtata atcagttgat
    12901 gcgttatgct gcattcttga ctataccttt attactttct tctttgattt tgggatattt
    12961 atattgggga gcaacggata ctgaagagaa gtatgcagaa gtcatggcgg ctacaggttc
    13021 agtcattcgt tacgaacttc ctgaccattc ggttgtctgg ttaaactccg gtagtacttt
    13081 acgttatcct accgttttta agaaagataa tcgtaatgtt gaattaaaag gtgaagccta
    13141 ttttgaagta gaagcggaca ggaaacggcc tttttacgtc aatactcctg ccgggttaag
    13201 tgtctatgtg tacggaacca aatttaatgt gaatgcttac gaagatgata atagtataga
    13261 aacggtatta gaaaagggta aagtaaacgt tatttcaccg gacggaaaaa caacagttca
    13321 gttagctcca ggagaacgat tgctttataa taaggtagat cagaaattgt tgaagggaaa
    13381 agtggatgtt tatgaaaagg tggcatggaa agacggtaag ttgatattcc gcaatgccga
    13441 gttgggtgaa atattcaaac ggctggcacg gcattttaat gtagatattc agtttaataa
    13501 tatatcggga aaagaatata aatatcgtgc gaccttccgt aatgaaacac tgccacagat
    13561 attggattat ctggctaagt ctgctgcctt gaagtggaga actgaggagg cggtacaaca
    13621 ggcagatgat acattcacaa agaaaaagat aatagtagat ttatattagt aaccataaaa
    13681 atgagaatag cctatgaga
//
