LOCUS       c00008_gnlPro..        15418 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LCHPLFKF_8.
ACCESSION   c00008_gnlPro..
VERSION     c00008_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 19:37:59
            Original ID  :: gnl|Prokka|LCHPLFKF_8
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15418
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15418
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3201:10328]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3202..10328
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15418
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15418
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             2..664
                     /locus_tag="ctg8_1"
                     /transl_table=11
                     /translation="KENNAKAEAARQANRDARRHAPATAQNAAAAIPSPVPAARPAQAP
                     AVPKVSAEPGKVNWSLQPGVKVRQSSNRNMLGAYGPEKAVDGNTSSRISDVSISSTGVV
                     EGKTAWFGIDFGRETNRTIEKVVIYTPANLTLLGTMEKFKVILYGNDKNVLAEKTFSTT
                     PSEKSTNVTSWKLDAPVKARALRVESANPSQPLALTEVEAYGPEDAEDTPAPAPAEK"
     CDS             767..973
                     /locus_tag="ctg8_2"
                     /transl_table=11
                     /translation="MECHALSSGIGFAYEIFRFLLHSPGAIQARTEENPKNVFAPDRKQ
                     PPFSTFPTPEKRSHPHMAPGEIS"
     CDS             complement(1089..1436)
                     /locus_tag="ctg8_3"
                     /transl_table=11
                     /translation="MNIINKIEQEQLKADVTPFNVGDTIKVHTRVIEGGKERIQIFQGI
                     VIAKRGSGINEAFTVRKISYGEGVERVFPLHTPRIAKIEVVNRGKVRRAKLHYLRGRIG
                     KDAMIVKSANR"
     CDS             complement(1546..3084)
                     /locus_tag="ctg8_4"
                     /transl_table=11
                     /translation="MFKSGLAVLFLLASWFSAACAYELLPAHVAVVYNGKSELSRRMAR
                     EYARVRGVPEGNLVSLDCPMTSEISRKEYEDTIRVPLLEAARKQRWWVPSGIASSPLMN
                     RKIFVLVLMADLPMKIRHETPAPLPGKGVNQMQTDRAAVDSELALLAVGGYERKSWQVN
                     PYFNKREDFVGSGLPSFLVCRLDGLTPDTCMRLVAEPANVEKKGLWGWAVVDRGGPYAQ
                     GDRWLDDVFERVREAGIPAYLDDWPQTLPEKFPLSRDTALYCGWYAGNANGPFSDPSFR
                     FRPGAIAMHLHSFSAADFKVPGRGWSSALLEKGAAVTVGNVYEPFLGACHRFDIFVDRL
                     LDGYTVAEASWMSMPVLSWQGVVFGDPLYRPYARMKDMDVEPTEEDRYFQGWWASSVQF
                     GDRWKDRSARLMESARKAPFSCLYEALALECLYRKEPARAGELLSSALDGAADARTRAR
                     LLLEILMAERARGGNKAFLQRADGIRGLMSSSAFLPALEEWLARVAPPPAPPKK"
     CDS             3202..3672
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_5"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.2e-25, bitscore:
                     80.1, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYCRPPPCIPYNHHTHMIQQIDHIGIAVKSLDATVPYYRDALGLG
                     EPHIEEVPTQKVRVAMFDVAGVHIELLEPTSPESAIAKAIEKKGEGIHHIAFKTNDIAG
                     NISQAKEAGLTVLNDPPVPGAHNTQVTFLHPKCTFGVLTEFCQHPGSCECGK"
     CDS             3704..5269
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_6"
                     /sec_met_domain="CT_Vparvula (E-value: 1.5e-216, bitscore:
                     709.8, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIDPKLIDDLNSRRKKVILSGGQEKIDKRHEKGEMTARDRMGYL
                     FEEGTFSEIGMHVRHNCHNFGMGKKEIPGDGVVSGFGLVDGRPVACAASDFLAQGGSLG
                     YMHAMKIADAQKYALKAGIPMVTVNDSGGARLQEGVAALSGYAQVFYNNVLASGVVPQI
                     SMILGPCAGGAAYSPALTDFIIMRNSGNAGMYITGPKVIEQVTYEKCTMDDIGSAAIHA
                     TVSGNVHFVADSDAHAMDILKRLLSFLPSNNTEEPPHKLDTPLDLSADEGMSDLIPGDN
                     RTPLDVQPIISRLVDNGDFLEVHKDFAKNVVVGFGRICGVVVGIIANQPNVKAGCLDID
                     SSDKAARFIRFCNAFNIPLVNLVDVPGFLPGKNQERGGIIRHGAKLIFAYSQATVPKVT
                     LIMRKAYGGAYIAMCCKDLGADAVFAWPGAEIAVMGAEGAVPVLYGRELKAVEDPAEKA
                     KRQGELLEEYREAFYNPYVAAGMGQITEVINPEETRAKIAFALRTLLNKKEVRPAKKHG
                     NIPL"
     CDS             5291..5737
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_7"
                     /sec_met_domain="OAD_gamma (E-value: 3e-10, bitscore: 30.8,
                     seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLTTLAFAFAQGIANVMNNLNYQVVGIMVVMLCLGGMAVILTVS
                     GSIAAAIQNRAKTAAPVAVPAAAPAAAGKPGMTPEMLAILSAAVDSAMTELTPEMVAVI
                     SAAVDAGLDGMSHRIVEIKQSPGSGYAAAGRAEIFASHRIRPSR"
     CDS             5810..6211
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 58.4; E-value:
                     1.6e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_8"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.2e-19, bitscore:
                     58.4, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLRITVDGKVFDVSVELLDQVSSTTAAPAPAPVAAPAPAASAP
                     VAAPAPAPAPAPAPAAAGAGDVPSPLAGKVVSLDVAAGTPVKAGDQILTLEAMKMNTII
                     YAPASGTLTAFCVNPGDTVQEGQALAKIG"
     CDS             6329..7954
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_9"
                     /sec_met_domain="OAD_beta (E-value: 1.9e-159, bitscore:
                     520.2, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVFSLSWQMVGMWGIAILLLYLGVAKQYEPLLMVPIAFGALIAN
                     IPDNGMLITQLNQQVISSNEQGEVTATSLNNVGYLRVHVAPLQQAPSKVPANLTTPESR
                     AQYQEIMQQPMQVYPGSQLTVSKIKSVRESQEKAKADAALLGDDSLTVDPNLKDFQNVT
                     EDNGNEPVFLLTNGEGTTVVRQQGVNYFDTSGNRIPVDLKTQKLEPLVVSAAGKYVAVG
                     QHTQELLVTSIHGGLYDWIGLGIKAEIFPPIIFLGVGALTDFGPLLAAPRTLLLGAAAQ
                     VGVAATFFMALFMGFTPNESASIGIIGGADGPTSIFLTMKLAPHLLGAVAVAAYTYMSL
                     VPLIQPPIMALLTTKKERLIRMKSLRTVSKSEKLFFAVLVTIVTILLIPDASPLIGMLM
                     LGNFLRECKVTERLVQASQNEIINIVTIFLGTSVGLTMQGDRFLQSETLLIILLGIVAF
                     GVATAGGVIAAKIMNLIWRKNPVNPLIGSAGVSAVPMAARVSHNVGQKYDPSNYLLMHA
                     MGPNVAGVIGTAVIAGYYIATLAK"
     CDS             7992..8771
                     /locus_tag="ctg8_10"
                     /transl_table=11
                     /translation="MNSAASFSTPPEEEGPCGDWTYHEWAEAFSTNDLARALPPGHIAV
                     CRVQTGGRGRFNRKWIGEEGGLWASFTVPLSAPEDTAAGVHWGHLPLVAGLALFNMLRG
                     MGLDSVRLRWPNDLLAGKSKLAGILVERPAENMAVIGIGINVFNDVSSIAGEIKDPPAR
                     LADLVRDCPSLHAVMASLGSHLNQVLSVFSHGGVPALQEGLSRAWAGERPVSILTDDET
                     VRGIFTGIDDQGNPVLSLPAGTVRTIPAHLINRLLEE"
     CDS             8832..10328
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: AcetylCoA_hydro"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: AcetylCoA_hyd_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_11"
                     /sec_met_domain="AcetylCoA_hyd_C (E-value: 9e-47, bitscore:
                     148.9, seeds: 181, tool: rule-based-clusters)"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 6.4e-44,
                     bitscore: 140.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYKVLTPEEAASLIKHGHHIGLSGFTPAGTAKAVTAALAKIAEA
                     EHEKGNPFQVSVFTGASTGDSCDGILSRAKAIRYRAPYTTNVDFRKAVNNGEIAYNDIH
                     LSQMAQEVRYGFMGNVDIAIIEACEVTADGKIYLTAAGGIAPTICRLADKIIVELNAAH
                     SKSAMGLHDVYEPLDPPYRREISIFKPSDRIGKPYIQVDPKKIVGVVETNWPDEARSFA
                     AADPLTDKIGQNVADFLAADMKRGIIPSTFLPLQSGVGNIANAVLGALGRDKTIPAFEM
                     YTEVIQNSVIGLIREGRVKFGSACSLTVTNDCLEGIYRDMDFFRDKLVLRPSEISNSPE
                     VIRRLGVISINTAIEADIYGNVNSTHIGGTKMMNGIGGSGDFTRNAYISIFTCPSVAKD
                     GKISAIVPMVSHHDHTEHDVNIIITEQGVADLRGKSPKERAQTIIENCVHPDYKNILWD
                     YLKLSDGKAQTPQSIRAALGMHAELARSGDMKNVDWAQYK"
     CDS             10447..11148
                     /locus_tag="ctg8_12"
                     /transl_table=11
                     /translation="MNWMIYPAARAFIKVCAVLFGAGAAAAVIIHLFMPFFLRSPRTAA
                     PFLLLGTGAELLSILSLSFLMFWGARVLLASRGSRITRNLSMLAFLPALYALLIPFAGM
                     PVPSQYTEMDRVWEAFLLLAAVTSFFSFPYTAGYEAAGRRLFLAWGIAAAGCGLQSALF
                     FLAILLRQFLSTAVPSLAAPVAWLAVLLSCGLEIMLATLSAILAQRLFKEVMSIASMPE
                     PIDPSMPGNRP"
     CDS             complement(11350..12213)
                     /locus_tag="ctg8_13"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLHPVTLSVSKQLLPVYDKPMVYYPISVLMLAG
                     IREILVISTPRDLPLYRDLLGDGSRFGVSFEYREQPRPEGLAQAFIIGEEFIGKDSVAL
                     VLGDNIFYGRGLTEKLRRAAELTSGATIFGYQVHDPQRFGVVEFNEEGKAVSIEEKPLR
                     PKSDIAVTGLYFYDNRVVEIAERIPKSSRGELEITSVNQEYLKQGLLRVEKLARGYTWL
                     DTGTHDTLLEASMFVRTLEHHQGFKVACLEEIAFNNGWISQETLRSQAGAMNNNGYGRY
                     LDELVK"
     CDS             complement(12223..13275)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GDP_Man_Dehyd"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_14"
                     /sec_met_domain="GDP_Man_Dehyd (E-value: 2e-99, bitscore:
                     323.1, seeds: 258, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVIVTGGAGFIGSNLVRLLLERGHEVLNIDALTYAGNIHSLDGS
                     ADSPAYRFLHADVRDASLMRRALREYAPDWVMHLAAESHVDRSIDDPGNFMTTNVMGTF
                     SMLQAALEYYRSLEGEKKERFRFHHISTDEVYGSLGKEGLFTESTPYRPHSPYSASKAS
                     SDHLVRAWHDTYGLPVLITNCSNNYGPYQFPEKLIPVVILKALGGEPIPVYGKGENVRD
                     WLYVGDHCEALLTVVSCGKPGETYNIGGNNEKTNLELVELLCSHLDELRPRPDGRSYRE
                     QISFVQDRPGHDLRYAIDASKIRRELGWTPRQDHSSGFRKTIQWYLDHEEWWRGILSGE
                     YRLERLGTNG"
     CDS             complement(13407..14351)
                     /locus_tag="ctg8_15"
                     /transl_table=11
                     /translation="MTSGGDAAGMNPAIKAAVDHARQLGMNPYVVYDGLEGLIDGKIKE
                     ATRELTNDMIYRGGTLLRSSRSKRFFDYEFRKQAYEHLKERNIDKLIIMGGDGSFRALN
                     DFFNDFEVPFAGIPATIDNDIAGTDYCLGVDTAQNVILDCIDSVRDTARSHHRAFVIET
                     MGRDCGYLAMTTALCSAADICIVPEIPYDLESIYKRLQPVINEEGSCIIAVVAEGTRVA
                     QYLTRWLTERAGMDTRLTVLGHVQRGGSPTARDRLMGTRFATRAVEALNNGDINQIMVY
                     HDGQYGYASLDSVAGQQYSVNQDIINLCRELSC"
     CDS             14480..15211
                     /locus_tag="ctg8_16"
                     /transl_table=11
                     /translation="MNDTAAAILKATAALRDGTEKLRFEAPVHVTYNPLTYAWGPHEQY
                     VRTYGNGEKSHLFLGMNPGPFGMAQTGVPFGEVDAVVNWLHIRGEVGRPEHTHPKRPVE
                     GFGCPRSEVSGRRLWGLFAEAFGTAANFFRHNYVANYCPLIWMGATGANITPDKLPAEQ
                     RAAVDAVCMEHLLSLITILNPHTLVGVGAYATQKLRDAASRLPGKSFTIGTLLHPSPAS
                     PIANKLWPERPIQQLKELGIL"
ORIGIN
        1 aaaggaaaat aacgcgaaag cggaagcggc aagacaagcg aacagggacg cgcgccgcca
       61 cgctccggcc accgcgcaaa acgccgctgc ggccattcct tcacctgttc cggccgcgcg
      121 tccggcgcag gcgccggcag ttcccaaagt ttccgcggaa cccggcaaag tcaattggag
      181 ccttcaaccc ggcgtcaagg ttcgccagag ttccaaccgc aacatgctgg gagcttacgg
      241 tccggaaaag gccgttgacg gcaataccag ctccaggatt tccgacgttt caatcagctc
      301 tacaggcgtg gttgagggaa aaaccgcctg gttcggcatt gacttcggca gggagaccaa
      361 ccgcaccata gaaaaggtgg tcatttacac gccggccaac ctgacgctgc tgggcaccat
      421 ggaaaaattc aaggtaatcc tctacggcaa tgacaaaaac gtgctggcgg aaaaaacctt
      481 cagcaccacc ccttcggaaa aatccaccaa cgtcacttcc tggaaactgg acgctccggt
      541 caaggcgcgc gccctgcgcg tggaatccgc aaatccctcc cagccgctgg cgttgacgga
      601 agtggaagcg tacggaccgg aagatgcgga ggacacaccg gctcccgcac ctgcggaaaa
      661 ataattatcc gcgcagccct gctcccgctt acccccctcc gggggccatg ctgaaaacta
      721 ccgtttcctt tccccttccc ggaaaagcag gacgggacag ggcctgatgg aatgtcacgc
      781 gctaagttcc gggattggct tcgcgtatga aattttccgg tttctgctcc attctccggg
      841 agccatacag gcccggacgg aggaaaatcc gaaaaacgta tttgctccgg accggaaaca
      901 gccgcccttc tccaccttcc ccaccccgga aaaacgctct catccccata tggctcccgg
      961 ggaaatatcc tgaagcggct gtcgtccctg tggacccctt tcccattcag gaaaaacaat
     1021 actccggaaa taaaaaaccc ggcgccgcct cacggcgggc cgggccagca aaatagcaat
     1081 tcttccgatt accggttggc agacttcaca atcatggcat ccttgccgat gcggccgcgc
     1141 agatagtgaa gtttggcgcg gcggactttg ccgcggttca cgacttcaat cttggcaatg
     1201 cggggagtat gcagggggaa tacgcgttcc acgccttcac cgtaggaaat tttgcggacg
     1261 gtgaaagctt cattgatgcc ggaaccgcgc ttggcgatca caatgccctg gaaaatctgg
     1321 atacgttcct tgccgccttc aataacacga gtgtgaacct tgatggtatc acctacgtta
     1381 aatggggtca catccgcctt gagttgctct tgctcgattt tgttgataat gttcatcttg
     1441 tgttatctat tgctggtgaa tatcagtaaa aggaaaactt acgggacgca gaatatgagc
     1501 cataatcccc taaaaggcaa tccaaatttg ccgtacgtcc ttaatttatt ttttcggcgg
     1561 ggccggcggc ggagccaccc tggcaagcca ttcctccagc gcaggaagaa aagcggagga
     1621 agacatgagg ccccggatgc cgtccgcccg ctgcagaaag gccttgttgc cgccccgggc
     1681 ccgttccgcc atcaggattt ccagcagcag gcgcgcgcgg gtgcgggcgt cagccgcgcc
     1741 gtccagggcg gaggaaagaa gctctccggc gcgggccggt tccttccggt acaggcattc
     1801 cagcgccaga gcttcataaa ggcaggaaaa aggggccttc cgggcggact ccatcaaacg
     1861 cgcggaacgg tccttccagc ggtctccgaa ctgcacggag gaagcccacc acccctggaa
     1921 ataacggtct tcttccgtcg gctccacgtc catatccttc atgcgggcgt atggacggta
     1981 cagggggtct ccgaacacca ccccctgcca ggacagcaca ggcatgctca tccaagaagc
     2041 ctccgccacg gtatagccgt ccaggaggcg gtccacaaaa atatcaaagc ggtggcaggc
     2101 gcccaggaac ggctcataca catttcccac cgtcacagca gcccccttct ccagcagggc
     2161 ggaactccac cccctgccgg ggaccttgaa atcggcggcg ctgaaggaat gcagatgcat
     2221 ggctatcgcc ccgggccgga agcggaacga aggatccgaa aacggtccgt tcgcattccc
     2281 cgcataccac ccgcagtaaa gagccgtatc ccggctcaag gggaattttt ccggcagggt
     2341 ctggggccag tcatccagat aagcgggaat gcccgcctcc ctcacgcgct cgaacacgtc
     2401 gtccagccac cggtccccct gggcataggg accgccccgg tccacaacgg cccaccccca
     2461 taaacctttt ttctccacgt tcgccggttc cgccaccagc cgcatgcagg tatcgggcgt
     2521 cagtccgtcc aggcggcata ccagaaacga aggaaggccg gaacccacaa aatcctccct
     2581 tttattaaaa tagggattca cctgccagga cttcctttca taaccgccca ccgccagcag
     2641 agccagttcg gaatccaccg cagcgcgatc cgtctgcatc tggttgacgc ctttcccggg
     2701 aaggggagcg ggcgtttcat gccgtatctt catcggcagg tccgccatca gcaccagcac
     2761 aaaaatcttc cggttcatca agggggagga cgcaatgccg gaaggcaccc accaccgttg
     2821 tttccgcgcc gcctccagca gcgggacgcg gatcgtatcc tcatattcct tccgcgaaat
     2881 ctcgctggtc atggggcaat ccagggaaac gagattccct tccggaacgc cgcgcacccg
     2941 cgcatactcc ctggccatgc ggcggctcag ctcggatttt ccgttataaa ccacggccac
     3001 atgagcgggc agcagctcat aggcacacgc ggcggaaaac cacgacgcca gcagaaataa
     3061 cacggctaat ccactcttga acatgcccct accatacctc atcttccggg gcaatcaagc
     3121 aggtgaaggg gacggccacg aattcgccat ttttccgctt ttcgcttcac atcctaaaaa
     3181 aatacgcttt aataactctt gatgtattgc aggcctcccc cctgcattcc ctataaccat
     3241 cacacgcata tgattcagca aattgaccat atcggcatcg ccgtcaagag ccttgacgcc
     3301 accgtcccct attaccgcga tgcgctcggg ctcggagagc cccacattga ggaagttccc
     3361 actcaaaagg tccgcgtcgc catgtttgac gttgccggag tccacatcga actgctcgaa
     3421 cccacctctc cggaaagcgc tatcgccaag gctattgaga aaaaagggga aggcatccac
     3481 cacatcgctt tcaagaccaa tgacatcgcc ggaaatatct cccaggccaa ggaagcaggc
     3541 cttaccgtgc tgaacgaccc gcccgtcccc ggcgctcaca acacgcaggt caccttcctg
     3601 catcccaagt gcaccttcgg cgtcctgacc gaattctgcc agcaccccgg cagctgcgaa
     3661 tgcggcaagt aacattctcc ctattcacca taccactaga ccaatggcta ttgatcccaa
     3721 attgattgac gatctgaaca gccgccgcaa gaaggtcatc ctcagcggcg gtcaggaaaa
     3781 gatcgacaag agacatgaaa agggcgaaat gacagcccgc gaccgcatgg ggtacctctt
     3841 tgaggaaggc accttctcgg aaatcggcat gcatgtgcgc cacaactgcc acaacttcgg
     3901 catgggtaag aaggaaatcc ccggcgacgg cgtcgtttcc ggtttcggcc tggtggacgg
     3961 ccgcccggta gcctgcgcgg cctccgattt cctggcccag ggcggttccc tcggctacat
     4021 gcacgccatg aaaattgcgg atgctcagaa gtatgcgctg aaagccggca tcccgatggt
     4081 gaccgtgaac gactccggcg gcgcgcgcct ccaggaagga gtggcggccc tttccggata
     4141 cgcccaggta ttttacaaca atgtgcttgc ctccggcgtg gttccgcaaa tctccatgat
     4201 cctgggcccc tgcgcgggcg gcgcggccta ctcccccgcc ctgacggact tcatcatcat
     4261 gcgcaattcc ggcaacgcgg gcatgtacat caccggtccc aaagtgattg aacaggtcac
     4321 gtatgaaaaa tgcacgatgg acgacatcgg ctccgccgcc attcacgcca ccgtgtccgg
     4381 caacgtccat ttcgtagcgg acagcgacgc gcacgccatg gacatcctga agaggcttct
     4441 ttccttcctt ccttccaaca acacggaaga accgccccac aaactggaca ctccgctgga
     4501 cctgagcgct gacgaaggca tgagcgacct gattcccggc gacaaccgca cgccgctgga
     4561 cgtccagccc atcatcagcc gtctggtgga caacggggac ttcctggaag tacacaagga
     4621 cttcgccaaa aatgtcgtcg tcggattcgg ccgcatctgc ggcgtggtgg tcggcatcat
     4681 cgccaaccag cccaatgtga aagccggctg cctggatatc gactcctccg acaaggccgc
     4741 acgcttcatc cgtttctgca acgcgttcaa tattccgttg gtgaacctgg tggacgtgcc
     4801 cggcttcctg cccggcaaga accaggaacg gggcggcatt atccgccacg gcgccaaact
     4861 tatcttcgcc tattcccagg ccacggtgcc caaagtcacc ctgatcatgc ggaaagccta
     4921 cggcggcgcc tacatcgcca tgtgctgcaa ggacctgggc gctgacgccg tcttcgcctg
     4981 gcctggtgcg gaaattgccg ttatgggtgc ggaaggcgcc gtcccggtac tctacggccg
     5041 cgaactgaag gctgtggaag acccggcgga aaaagccaag cgccagggag aacttctgga
     5101 agaataccgg gaagcctttt acaacccgta tgtggcggcc ggcatgggac agatcacgga
     5161 agtcatcaat ccggaagaaa cccgcgccaa aatcgccttc gccctgcgca ccctgctgaa
     5221 caagaaggaa gtgcgcccgg ccaagaaaca cggcaacatt ccgctctaac atccatccca
     5281 acggattcat atgttactta caacactcgc ttttgccttc gcacagggca tcgccaacgt
     5341 tatgaacaat ctgaactatc aggttgtcgg catcatggtg gttatgctgt gcctgggagg
     5401 catggccgtc attctgaccg tcagcggctc catcgccgcc gccattcaga acagggccaa
     5461 aaccgccgct cccgtagccg tgcctgccgc cgctcccgct gcggcgggca aaccgggcat
     5521 gactccggaa atgctcgcca tcctttccgc cgccgtggat tccgccatga cggagcttac
     5581 tccggaaatg gtggccgtca tctccgccgc cgtggacgca ggcctggacg gcatgagcca
     5641 ccgcatcgtg gaaatcaagc aatccccggg ttccggctat gcggccgcgg gcagggcgga
     5701 gattttcgcc tcccaccgca tcaggccttc ccgctgaact actgcattat tcacccttac
     5761 cccgcccatg cggaatcatt taacttaata tcccatacca cacactatta tgaagaaact
     5821 tcgcatcacc gtagacggca aagtatttga cgtatccgta gaacttctgg accaggtgtc
     5881 ctccaccact gcggcgccgg cccccgcacc tgtggccgct cccgctcctg cggcttccgc
     5941 ccccgtggcc gccccggccc cggctcccgc acctgcgccg gctccggccg ccgccggcgc
     6001 aggagacgtt cccagcccgc ttgccgggaa ggtcgtctcc ctggacgtgg cagcaggcac
     6061 ccccgtgaag gccggtgacc agattctgac gctggaagcc atgaagatga acaccatcat
     6121 ctacgctccc gcctccggca cgctcaccgc tttctgcgtg aacccgggcg acacggttca
     6181 ggaaggtcag gcactggcca aaattggtta atcccggcgg cggcagcccg gaaacgccaa
     6241 cagtcccggg ctccggctca gataataaac cgctacaaaa atattcccta tgagtctttt
     6301 tgattcatta atcacctttt tacaggggat gggcgtcttc tccctatcat ggcagatggt
     6361 agggatgtgg ggcattgcca ttctcctcct gtatctgggt gtagccaagc aatacgaacc
     6421 gctcctgatg gttcccattg ctttcggcgc cctcattgcc aacattccgg ataacggaat
     6481 gctcatcacc cagctgaacc agcaggtcat ctcctccaat gaacaggggg aagtaaccgc
     6541 cacgtctctg aacaacgtgg ggtacctgcg cgttcacgtg gctccgcttc agcaggctcc
     6601 ctccaaggtg ccggccaacc tgaccacgcc tgaatcccgt gcccagtatc aggaaatcat
     6661 gcagcagccc atgcaggttt accccggcag ccagctgacc gtttccaaga tcaagtccgt
     6721 gcgggaatcc caggaaaaag ccaaggctga cgcggccctc ctgggcgacg acagcctgac
     6781 ggtggacccc aacctgaagg atttccagaa cgtgacggag gacaacggca atgaaccggt
     6841 cttcctgctc acgaacggag aagggaccac cgtcgtccgc cagcagggcg tcaattactt
     6901 tgacaccagc ggcaaccgga ttccggtgga tctgaaaacc cagaagctgg agcccctggt
     6961 ggtttcagcc gcaggcaaat acgtggccgt aggccagcat acccaggaac tgctggtcac
     7021 ctccatccac gggggcctgt atgactggat cgggctgggc atcaaggctg aaattttccc
     7081 gcccatcatc tttctgggcg taggagccct gacggacttc ggcccgctgc ttgccgctcc
     7141 gcgcaccctg cttctgggcg cagcggccca ggtgggcgta gccgccacgt tcttcatggc
     7201 cctgttcatg gggttcaccc cgaatgaatc cgcgtccatc ggcatcattg gcggcgctga
     7261 cggccccacc tccatcttcc tgacgatgaa gctggccccg cacctgctgg gcgccgtggc
     7321 cgtggccgca tacacgtaca tgtccctggt tccgctgata cagccgccca tcatggcgtt
     7381 gctgacgacc aagaaggaac gcctcatccg catgaaatcc ctgcgaacgg tcagcaagag
     7441 cgaaaaactg tttttcgccg tgctggtaac cattgtcacc attttgctga ttccggacgc
     7501 atccccgctg atcggcatgc tgatgcttgg caacttcctg cgcgaatgca aggtgacgga
     7561 acgcctggtt caggcctccc agaatgaaat catcaacatc gtcaccatct tcctgggaac
     7621 ctccgtgggg ctcacgatgc agggcgaccg cttcctgcag tcggaaacgc tgctgatcat
     7681 ccttctgggt atcgtcgcct tcggcgtggc aacagcgggc ggagtgattg ccgccaagat
     7741 tatgaacctc atctggcgca agaatccggt caaccccctg atcgggtccg caggcgtctc
     7801 cgccgtcccg atggcagccc gcgtctccca caatgtgggc cagaagtacg acccctccaa
     7861 ctacctgctc atgcacgcca tgggcccgaa cgttgcaggc gtgatcggca ccgcagtcat
     7921 cgcgggctac tacatcgcca ctctggcgaa ataaccagaa ttgaaaatta ctcccggcct
     7981 cggcccgtcc catgaattcc gcagcctcat tttccacccc tccggaggag gaaggaccat
     8041 gcggcgactg gacttatcat gaatgggccg aggctttttc caccaatgat ctggcccgag
     8101 ccctcccccc ggggcatatt gccgtctgcc gcgttcagac aggaggccgc ggcaggttca
     8161 accgcaaatg gataggggag gaaggcggcc tgtgggcatc cttcaccgtc cccctgtccg
     8221 ctcctgagga tacagcggcc ggcgtgcact ggggccattt gcccctggtt gcggggctgg
     8281 ccctgttcaa catgctccgc ggcatggggc tggattccgt gcgcctgcgc tggccgaacg
     8341 acctgctggc gggcaaatcc aaactggcgg gaatactggt ggaacgcccg gcggagaaca
     8401 tggccgtcat cggcatcggc atcaatgttt tcaatgatgt atcctccatc gccggggaaa
     8461 tcaaggaccc tccggcaagg ctggcggatc ttgttcggga ctgcccttcc ctgcacgccg
     8521 tcatggcttc cctgggcagt catttgaacc aggttctttc cgtcttttcc cacggcggcg
     8581 tccccgccct tcaggagggt ctgtcccggg catgggccgg agaaaggccg gtttccattc
     8641 ttacggatga cgaaaccgtc cggggcattt ttacagggat tgacgatcag ggcaatcctg
     8701 tgctatccct tccggccggc accgtccgca ccattccggc gcacctgatc aacaggctcc
     8761 tcgaagaatg agcctgccgc tccgttttac acggggtttc tttctttttt catccaacaa
     8821 aaatcactga catgagttac aaggtactga caccagaaga agcagcaagc ctgatcaagc
     8881 atggccacca tattgggctg agcggattca cgcccgccgg aacggccaag gccgttacgg
     8941 ctgcgctggc aaaaatcgca gaagcggaac atgagaaggg gaaccctttc caggtgagcg
     9001 tcttcaccgg tgcttccacc ggcgattcct gcgacgggat cctttcccgg gccaaggcaa
     9061 tccgctaccg cgctccctac accaccaacg ttgatttccg caaggcggtg aacaacgggg
     9121 aaatcgccta taatgacatc catttgtccc agatggccca ggaagtgcgc tacgggttca
     9181 tgggcaacgt ggacatcgcc attattgaag cctgtgaagt cacggccgac ggaaaaattt
     9241 acctgacggc cgcgggcggg atcgctccca ccatctgccg cctggcagac aaaattatcg
     9301 tggaattaaa cgccgcccac agcaagagcg ccatgggcct gcacgacgtt tacgaacccc
     9361 tggatcctcc ctaccgccgc gaaatctcca tcttcaaacc cagcgaccgc atcggcaagc
     9421 cgtacatcca ggttgacccg aaaaagattg tgggcgttgt ggaaaccaac tggccggatg
     9481 aagcccgttc cttcgccgca gcggatcccc tgaccgataa aatcgggcag aacgtggccg
     9541 atttcctggc tgccgacatg aaacggggca tcattccctc cacgttcctg cctctccagt
     9601 ccggcgtagg caacatcgca aacgcggtgc tgggcgccct gggccgcgac aagacgattc
     9661 ccgcgttcga gatgtacacg gaagtcatcc agaactccgt catcggcctg attcgggagg
     9721 gccgcgtgaa attcggaagc gcctgctccc tgaccgtgac gaacgactgc ctggaaggca
     9781 tttacaggga tatggacttt ttccgcgaca aactggtgct ccgtccctcg gaaatatcca
     9841 acagcccgga agttatccgc cgtctcggcg tcatctccat caacaccgcc attgaagccg
     9901 acatttacgg gaacgtcaac tccacgcaca ttggcggcac gaagatgatg aacggcatcg
     9961 gcgggtccgg cgacttcacg cgtaacgcct acatctccat tttcacctgc ccgtccgttg
    10021 ccaaggacgg caagatcagc gctatcgtcc ccatggtttc ccaccatgac catacggaac
    10081 atgacgtcaa tatcattatt accgagcagg gggtcgcgga cctgcgcggc aagagcccga
    10141 aagaacgggc ccagaccatt attgaaaact gcgtccaccc ggattacaaa aacatcctct
    10201 gggattacct gaagctgtcc gacggcaaag cccagacacc gcaatccatc agggccgctt
    10261 tgggcatgca cgccgaactt gccagaagcg gagacatgaa gaatgtcgac tgggcccagt
    10321 ataagtaatt ccgcatgccg tcattcgcat tggcatccat gaattcacgc taacccctca
    10381 ggaccgcttc cgcaaaggga gcggtccttt tcctttttcc catcccctct actccttctc
    10441 ttcaccatga actggatgat ttacccggca gccagggctt tcatcaaagt ctgcgccgtt
    10501 cttttcggcg cgggcgcagc agcggcagtc atcatccatc tgttcatgcc ttttttcctc
    10561 cgctctcccc ggacagccgc acccttcctg cttttgggca caggggcgga attgctctcc
    10621 atcctttccc tgtccttcct catgttctgg ggcgccagag tcctgctggc ctcccgcgga
    10681 agcagaataa caagaaatct gagcatgctg gccttcctgc ccgccctgta cgccctcctc
    10741 attccgtttg cgggcatgcc cgtcccatcg caatatacgg aaatggacag ggtttgggag
    10801 gccttcctcc ttctggcggc cgtcacttct ttcttttcct tcccttatac ggcgggatac
    10861 gaagccgcag gcaggagatt attcctggcc tggggcatcg cagcggcagg ctgcggtttg
    10921 cagagcgccc tgttttttct tgccatcctg ttgcgtcagt tcctgtccac cgcagttccc
    10981 tccctggcag cgcctgttgc atggctggcc gttcttctgt cctgcggcct ggaaatcatg
    11041 ctggcgaccc tttccgctat tctggcgcag cgcctgttta aagaggtcat gtccatagca
    11101 tccatgccgg aaccgattga tccttccatg ccgggcaacc gtccctgact ttcctcccct
    11161 ccgtttttac cggcctgccg gaagagcacc ctcattcccc ggcatgaaag gcttttacgg
    11221 ctttgtgcaa aaagccgtcc ggaaatttcc gccggtggaa cggaatccgt atggaaagca
    11281 acccgcccca ccccggaaag ccgcgggttc gcaggccccc tcccgtttcc acgccgacgg
    11341 cagacagccc tatttcacca attcatccag ataacggcca taaccgttat tattcatggc
    11401 tccggcctgg gagcgcagcg tttcctggga aatccagccg ttattaaagg ctatctcctc
    11461 caggcaggct accttgaacc cctggtgatg ctccagagta cgaacgaaca tggaagcctc
    11521 caaaagggta tcgtgcgtgc ccgtatccag ccacgtatag ccgcgcgcca gtttttccac
    11581 gcgcaacagg ccctgcttca ggtattcctg attcacagag gtgatttcca actcgccgcg
    11641 ggaagacttg ggaatccgtt cggctatctc caccacccgg ttgtcgtaaa aatagagacc
    11701 cgtcaccgca atatccgatt tgggcctgag cggtttttcc tcaatggaaa ccgccttccc
    11761 ctcctcattg aattccacta ccccgaaacg ctgcgggtca tgcacctggt aaccgaaaat
    11821 ggtcgctccg ctcgtcagtt cggcggcccg cctcagcttc tccgtcaggc cgcgcccgta
    11881 aaaaatattg tcccccagca ccagggcaac ggaatccttt cctatgaact cctctccaat
    11941 aataaaggcc tgagccagcc cctccggcct gggttgttcc ctgtattcaa aggaaacgcc
    12001 gaacctgctg ccgtccccca gcaaatcccg gtacaggggc agatcccggg gcgtggaaat
    12061 aacaaggatt tcccgtattc cggccagcat cagcacggag atgggataat aaaccatcgg
    12121 cttatcgtaa acgggcagca attgcttgct gacggaaagc gtaacgggat gcagccgcgt
    12181 gccgcttccc ccggccagaa caataccctt catatcaaat tcctagccat tggttccaag
    12241 acgttccagg cggtattccc cggacaggat gccccgccac cattcctcat ggtccagata
    12301 ccactgaatg gtctttctga atccggaaga atggtcctgg cgcggagtcc accccaattc
    12361 cctccgtatt ttggaagcgt caatcgcata gcgcaggtca tggcccggcc tgtcctgcac
    12421 aaaggagatt tgttcccggt agctccggcc gtccggacgg ggccgcagtt catccagatg
    12481 ggaacacagc agctccacca gctccagatt ggttttctcg ttattgccgc cgatgttgta
    12541 cgtttccccc ggttttccgc aggaaacgac cgtcaacagc gcctcgcagt gatcccccac
    12601 atacagccag tcccgcacgt tttccccttt gccgtataca ggaatgggtt ccccgcccag
    12661 cgctttcagg ataacgacgg gtatcagctt ttccgggaac tggtaagggc cgtaattgtt
    12721 ggaacagttg gtgatcagca cgggcaaccc gtacgtatcg tgccaggcgc gcaccaggtg
    12781 gtcgctggag gccttgctgg cggaatacgg ggaatggggg cgatacggcg tggactccgt
    12841 gaacaggcct tcctttccca gggagccgta cacttcatcc gtggaaatgt gatgaaagcg
    12901 gaaacgctcc tttttctctc cctccaggga acggtaatat tccagggcgg cctgaagcat
    12961 ggaaaaagtg cccatgacgt tggtggtcat aaaatttccc ggatcgtcaa tggaacggtc
    13021 cacatgggat tccgccgcca ggtgcatcac ccagtccgga gcgtactccc gcaaagcgcg
    13081 ccgcatcagg gaagcgtccc ggacgtcggc gtgcagaaag cggtatgccg gagaatccgc
    13141 cgagccgtcc agtgaatgga tgttgccggc ataggtcagg gcgtcaatat tcaggacttc
    13201 atggccgcgc tccagcagca gcctgaccag attggagccg atgaatccgg cgccgcccgt
    13261 aacgataact ttcatagcac tgttttcagg gaaagatgcg gcgccatcat acagcagcgg
    13321 cgtttttttt caaaacaaat ccgcccatgc cgcgggaacg tggcggcatg ggcgggaaaa
    13381 agcgggttcc gtaaccgctg agacggctag cagctcagct cccggcaaag gttgatgata
    13441 tcctggttca cggagtactg ctgcccggca acggaatcca gggaggcata gccgtactgg
    13501 ccgtcatgat acaccatgat ctggttgatg tccccgttgt tcagagcttc cacggcgcgg
    13561 gtggcaaaac gggtgcccat caggcggtca cgggcggtgg gggaaccgcc gcgctgtaca
    13621 tggcccagca cagtcaggcg ggtatccatg ccggcgcgtt ccgtcagcca gcgggtcagg
    13681 tactgcgcca cgcgggtgcc ttccgccacc acggcaatga tgcagcttcc ttcctcattg
    13741 atgacaggct ggaggcgctt gtaaatggat tccaggtcat acggaatttc agggacaatg
    13801 cagatatccg ccgcgctgca aagagcggtg gtcatcgcca gatagccgca gtcccggccc
    13861 atcgtttcaa tcacgaaagc gcggtgatgg gaacgggccg tatcacgaac ggaatcaatg
    13921 caatccagaa tcacgttctg ggccgtatcc acgcccaggc agtagtccgt gccggcaatg
    13981 tcgttgtcaa tcgtggccgg aataccggca aaaggcactt caaaatcatt gaaaaagtcg
    14041 ttcagggcgc ggaaggaacc gtccccgccc atgatgatga gcttgtcgat gttgcgttcc
    14101 ttcagatgct cgtaggcctg cttgcggaat tcgtagtcga aaaagcgttt ggatcgtgag
    14161 gaacggagga gagttccgcc cctgtagatc atatcgttgg tcagttcccg ggtggcttcc
    14221 ttgatttttc catcgatcag cccttccaag ccgtcataaa caacgtacgg gttcatccca
    14281 agctggcggg catgatccac tgccgccttg atcgccgggt tcattccggc ggcatcgccg
    14341 ccagatgtca taatggctat tccactcata agtaataagg ttaacttgtc cggggggaaa
    14401 tgttaccggg cggaacaaat aatgcaagcg cggagttttt actggcgcaa taaacggcaa
    14461 cgcttcatga tgcggaggca tgaacgacac tgcagcagcc attctgaaag ccacggccgc
    14521 cctccgggac ggcacggaga agctccggtt cgaagccccg gtccatgtta cctacaaccc
    14581 tctcacctat gcatgggggc cgcatgaaca gtatgtgcgc acctacggaa acggggaaaa
    14641 gagccatctg ttcctgggca tgaatcccgg ccccttcggc atggcccaga caggcgtccc
    14701 cttcggggaa gtggacgccg tcgtcaactg gctgcacatc cgcggagaag tcgggcggcc
    14761 ggaacatacc caccccaaac gtcccgtgga gggtttcggc tgccccaggt cggaagtcag
    14821 cggccgccgc ctctggggac ttttcgcgga agctttcggc actgcggcaa acttcttccg
    14881 tcacaattac gtggccaatt actgtccgct gatctggatg ggagccaccg gagccaacat
    14941 tacgccggac aaactgccgg cggaacagcg cgccgccgtg gacgcagtat gcatggaaca
    15001 cctgctttcc ctcatcacca tcctgaatcc ccacacgctg gtgggtgtgg gtgcctacgc
    15061 cacgcagaag ctgcgggacg ccgcctcccg gctccccggc aaaagcttca ccatcggcac
    15121 gttgctccac ccaagccccg ccagccccat cgccaacaag ctctggccgg aacgccccat
    15181 ccagcagctt aaggaactgg gcattttata aaaagagcgg aggaggtaga gcggagagtt
    15241 ccgtgacatg gaaggaatca ccagagcgac aggctggaaa tcggcagttc atcttgttct
    15301 cctccaaatc tacatcgttt tgaaggaata tccggccccc tttactggct tgatttgccc
    15361 agggacacgg ccttcctgac ggaagaaaag cacgccggca tctaccggga cggagaag
//
