LOCUS       c00023_gnlPro..        13690 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MCEDKMEO_23.
ACCESSION   c00023_gnlPro..
VERSION     c00023_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 14:22:50
            Original ID  :: gnl|Prokka|MCEDKMEO_23
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13690
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13690
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3888:11035]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3889..11035
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13690
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13690
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             944..1381
                     /locus_tag="ctg23_1"
                     /transl_table=11
                     /translation="MLGAYGPEKAVDGNTSSRISDVSISATGVVEGKTAWFGIDFGRET
                     NRTIEKVVIYTPANLTLLGTMEKFKVILYGNDKNVLAEKTFSTTPSEKSTNVTSWKLDA
                     PVKARALRVESANPSQPLALTEVEAYGPEDAEDPPVSAPAE"
     CDS             1428..1691
                     /locus_tag="ctg23_2"
                     /transl_table=11
                     /translation="MLNPPFPFPLPESRLGQGLMECHALSSWFGFAYEIFRFLLHSPEA
                     IQARTEENPKNVFAPDRKQPPLSTFPTPEKRSHPHMAPGEIS"
     CDS             complement(1808..2155)
                     /locus_tag="ctg23_3"
                     /transl_table=11
                     /translation="MNIINKIEQEQLKADVTPFNVGDTIKVHTRVIEGGKERIQIFQGI
                     VIAKRGSGINEAFTVRKISYGEGVERVFPLHTPRIAKIEVVNRGKVRRAKLHYLRGRIG
                     KDAMIVKSANR"
     CDS             complement(2265..2504)
                     /locus_tag="ctg23_4"
                     /transl_table=11
                     /translation="MKLWRWNACTGRNRSAPADARTRARLLLEILMAERARGGNKAFLQ
                     RADGIRGLMSSSAFLPALEEWLARVAPPPAPPKK"
     CDS             complement(2449..3771)
                     /locus_tag="ctg23_5"
                     /transl_table=11
                     /translation="MFKSGLAVLFLLASWFSAACAYELLPAHVAVIYNGKSELSRRMAR
                     EYARVRGVPEGNLVSLDCPMTSEISRKEYEDTIRVPLLETARKQRWWVPSGIASSPLMN
                     RKIFVLVLMADLPMKIRHETPALLPGKGVNQMQTDRAAVDSELALLAVGGYERKSWQVN
                     PYFNKREDFVGSGLPSFLVCRLDGLTPDTCMRLVTEPANVEKKGLWGWAVVDRGGPYAQ
                     GDRWLDDVFERVREAGIPAYLDDWPQTLPEKFPLSRDTALYCGWYAGNANGPFSDPSFR
                     FRPGAIAMHLHSFSAADFKVPGRGWSSALLEKGAAVTVGNVYEPFLGACHRFDIFVDRL
                     LDGYTVAEASWMSMPVLSWQGVVFGDPLYRPYARMKDMDVEPTEEDRYFQGWWASSVQF
                     GDRWKDRSARLMESARKAPFSCLYEALALECLYRKEPVRAG"
     CDS             3889..4359
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_6"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.2e-25, bitscore:
                     80.1, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYCRPPPCIPYNHHTHMIQQIDHIGIAVKSLDATVPYYRDALGLG
                     EPHIEEVPTQKVRVAMFDVAGVHIELLEPTSPESAIAKAIEKKGEGIHHIAFKTNDIAG
                     NISQAKEAGLTVLNDPPVPGAHNTQVTFLHPKCTFGVLTEFCQHPGSCECGK"
     CDS             4391..5596
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_7"
                     /sec_met_domain="CT_Vparvula (E-value: 2.3e-153, bitscore:
                     501.4, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIDPKLIDDLNSRRKKVILSGGQEKIDKRHEKGEMTARDRMGYL
                     FEEGTFSEIGMHVRHNCHNFGMGKKEIPGDGVVSGFGLVDGRPVACAASDFLAQGGSLG
                     YMHAMKIADAQKYALKAGIPMVTVNDSGGARLQEGVAALSGYAQVFYNNVLASGVVPQI
                     SMILGPCAGGAAYSPALTDFIIMRNSGNAGMYITGPKVIEQVTYEKCTMDDIGSAAIHA
                     TVSGNVHFVADSDAHAMDILKRLLSFLPSNNTEEPPHKLDTPLDLSADEGMSDLIPGDN
                     RTPLDVQPIISRLVDNGDFLEVHKDFAKNVVVGFGRICGVVVGIIANQPNVKAGCLDID
                     SSDKAARFIRFCNAFNIPLVNLVDVPGFLPGKNQERGGIIRHXXXXNLSSPIPRPRCPK
                     SP"
     CDS             5599..5961
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_8"
                     /sec_met_domain="CT_Vparvula (E-value: 1.9e-46, bitscore:
                     148.8, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKAYGGAYIAMCCKDLGADAVFAWPGAEIAVMGAEGAVPVLYGR
                     ELKAVEDPAEKAKRQGELLEEYREAFYNPYVAAGMGQITEVINPEETRAKIAFALRTLL
                     NKKEVRPAKKHGNIPL"
     CDS             5983..6435
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_9"
                     /sec_met_domain="OAD_gamma (E-value: 3.6e-10, bitscore:
                     30.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLTTLAFAFAQGIANVMDNLNYQVVGIMVVMLCLGGMAVILTVS
                     GSIAAAIQNRAKAKTAAPVAVPAAAPAAAGKPGMTPEMLAILSAAVDSAMTELTPEMVA
                     VISAAVDAGLDGMSHRIVEIKQSPGSGYAAAGRAEIFASHRIRPSR"
     CDS             6508..6909
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 58.4; E-value:
                     1.6e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_10"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.2e-19, bitscore:
                     58.4, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLRITVDGKVFDVSVELLDQVSSTTAAPAPAPVAAPAPAASAP
                     VAAPVPAPAPAPAPAAAGAGDVPSPLAGKVVSLDVAAGTPVKAGDQILTLEAMKMNTII
                     YAPASGTLTAFCVNPGDTVQEGQALAKIG"
     CDS             7027..8652
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_11"
                     /sec_met_domain="OAD_beta (E-value: 1.7e-159, bitscore:
                     520.4, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVFSLSWQMVGMWGIAILLLYLGVAKQYEPLLMVPIAFGALIAN
                     IPDNGMLITQLNQQVISSNEQGEVTATSLNNVGYLRVHVAPLQQAPSKVPANLTTPESR
                     SQYQEIMQQPMQVYPGSQLTVSKIKSVRESQEKAKADAARLGDDSLTVDPNLKDFQNVT
                     EDNGNEPVFLLTNGEGTTVVRQQGVNYFDTSGNRIPVDLKTQKLEPLVVSAAGKYVAVG
                     QHTQELLVTSIHGGLYDWIGLGIKAEIFPPIIFLGVGALTDFGPLLAAPRTLLLGAAAQ
                     VGVAATFFMALFMGFTPNESASIGIIGGADGPTSIFLTMKLAPHLLGAVAVAAYTYMSL
                     VPLIQPPIMALLTTKKERLIRMKSLRTVSKSEKLFFAVLVTIVTILLIPDASPLIGMLM
                     LGNFLRECKVTERLVQASQNEIINIVTIFLGTSVGLTMQGDRFLQSETLLIILLGIVAF
                     GVATAGGVIAAKIMNLIWRKNPVNPLIGSAGVSAVPMAARVSHNVGQKYDPSNYLLMHA
                     MGPNVAGVIGTAVIAGYYIATLAK"
     CDS             8690..9478
                     /locus_tag="ctg23_12"
                     /transl_table=11
                     /translation="MNSAASFSTPPEEEGPCGDWTYHEWAEAFSTNDLARALPPGHIAV
                     CRVQTGGRGRFNRKWIGEEGGLWASFTVPLSAPEDTAAGVHWGHLPLVAGLALFNMLRG
                     MGLDSVRLRWPNDLLAGKSKLAGILVERPAENMAVIGIGINVFNDVSSIAGEIKDPPAR
                     LADLVRDCPSLHAVMASLGSHLNQVLSVFSHGGVPALQEDLSRAWAGERPVSILTDDET
                     VRGIFTGXXXIDDQGNPVLSLPAGTVRTIPAHLINRLLEE"
     CDS             9539..11035
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: AcetylCoA_hydro"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: AcetylCoA_hyd_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_13"
                     /sec_met_domain="AcetylCoA_hyd_C (E-value: 9e-47, bitscore:
                     148.9, seeds: 181, tool: rule-based-clusters)"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 5.8e-44,
                     bitscore: 140.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYKVLTPEEAASLIKHGHHIGLSGFTPAGTAKAVTAALAKIAEA
                     EHEKGNPFQVSVFTGASTGDSCDGILSRAKAIRYRAPYTTNVDFRKAVNNGEIAYNDIH
                     LSQMAQEVRYGFMGNVDIAIIEACEVTADGKIYLTAAGGIAPTICRLADKIIVELNAAH
                     SKSAMGLHDVYEPLDPPYRREISIFKPSDRIGKPYIQVDPKKIVGIVETNWPDEARSFA
                     AADPLTDKIGQNVADFLAADMKRGIIPSTFLPLQSGVGNIANAVLGALGRDKTIPAFEM
                     YTEVIQNSVIGLIREGRVKFGSACSLTVTNDCLEGIYRDMDFFRDKLVLRPSEISNSPE
                     VIRRLGVISINTAIEADIYGNVNSTHIGGTKMMNGIGGSGDFTRNAYISIFTCPSVAKD
                     GKISAIVPMVSHHDHTEHDVNIIITEQGVADLRGKSPKERAQTIIENCVHPDYKNILWD
                     YLKLSDGKAQTPQSIRAALGMHAELARSGDMKNVDWAQYK"
     CDS             11154..11732
                     /locus_tag="ctg23_14"
                     /transl_table=11
                     /translation="MNWMIYPAARAFIKVCAVLFGAGAAAAVLIHLFMPFFLRSPRTAA
                     PFLLLGTGAELLSILSLSFLMFWGARVLLASRGSRITRNLSMLAFLPALYALLIPFAGM
                     PVPSQYTEMDRVWEAVLLLAAVTSFFSFPYTALRFAERPVFSCRPVASVPVHRSSLPGS
                     ACCMAGRSSVLRPGNHAGGPFRSSGAAPI"
     CDS             complement(12005..12745)
                     /locus_tag="ctg23_15"
                     /transl_table=11
                     /translation="MLAGIREILVISTPRDLPLYRDLLGDGSRFGVSFEYREQPRPEGL
                     AQAFIIGEEFIGKDSVALVLGDNIFYGRGLTEKLRRAAELTSGATIFGYQVHDPQRFGV
                     VEFNEEGKAVSIEEKPLRPKSDIAVTGLYFYDNRVVEIAKRIPKSSRGELEITSVNQEY
                     LKQGLLRVEKLARGYTWLDTGTHDTLLEASMFVRTLEHHQGFKVACLEEIAFNNGWISQ
                     EMLRSQAGAMNNNGYGRYLDELVK"
     CDS             complement(12926..13321)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GDP_Man_Dehyd"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_16"
                     /sec_met_domain="GDP_Man_Dehyd (E-value: 4.8e-21, bitscore:
                     65.5, seeds: 258, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VRDWLYVGDHCEALLTVVSCGKPGETYNIGGNNEKTNLELVELLC
                     SHLDELRPRPDGRSYREQISFVQDRPGHDLRYAIDASKIRRELGWTPRQDHSSGFRKTI
                     QWYLDHEEWWRGILSGEYRLERLGTNG"
ORIGIN
        1 atttgactgg ccggttatgg aaaagggtgc gctccatccg ggcatgattg gcgtccgttc
       61 agcatcaggg cgtcccgcca tcaaaatatg cccgcttata gagttgcttc cgtaggggaa
      121 tttaaggtag agtgggaatc aatactattc cacctctctt ttccatgtct gccgacgatt
      181 cctttcccat ggaccagatt tcctctctct ttccccaatt ggaaaatatc cagcttgtcg
      241 gagccaaagg cccccagcaa attttcacag ctaccctgaa atcaaacttt nnnnnnnnnn
      301 nnnnnnnnnn natgctgcgg gtggttccca cggaagaagc cggcatcttc ggctgggatc
      361 ctgaattcat cgtccgctcc ctcaccatcg tggaacaatc ccaccagggg ctcctgcgcg
      421 tttatgaagt aggacaggcg gggccgttta ctttcatcat ctccgaacac tccccctatc
      481 cgcgtctggc ggatatggaa acccttcccc aaatatctcc ccaggcggcg ctcaacctgg
      541 tgcgcaacat ggcggaagga ctgctgacgc tgcaccggaa aaacattttt cacgggggca
      601 tcacgcccaa gctgatttgc ctgcgcgaag acggcggaga cgccctgctg ctgcccatca
      661 acatttatcc agcccaacct ccggtggaca tgggggactt cgcctctccg gagtgggtca
      721 ccggagcgga aaccacgttc acgccgggca tggatattta cgcactgggg ctggcgcttt
      781 acattctgct tacccgcaaa acgccgctgc ggccattcct tcacctgttc cggccgcgcg
      841 tccggcgcag gcgccgacag ttcccaaagt ttccgcggaa cccggcaaag tcaattggag
      901 ccttcaaccc ggcgtcaagg ttcgccagag ttccaaccgc aacatgctgg gagcttacgg
      961 tccggaaaag gccgttgacg gcaataccag ctccaggatt tccgacgttt caatcagcgc
     1021 cacaggcgtg gttgagggaa aaaccgcctg gttcggcatt gacttcggca gggagaccaa
     1081 ccgcaccata gaaaaggtgg tcatttacac gccggccaac ctgacgctgc tgggcaccat
     1141 ggaaaaattc aaggtaatcc tctacggcaa tgacaaaaac gtgctggcgg aaaaaacctt
     1201 cagcaccact ccttcggaaa aatccaccaa cgtcacttcc tggaaactgg acgctccggt
     1261 caaggcgcgc gccctgcgcg tggaatccgc aaatccctcc cagccgctgg cgttgacgga
     1321 agtggaagcg tacggaccgg aagatgcgga ggacccaccg gtttccgcac ctgcggagta
     1381 ataattatcc gcgcagccct gcacccgctc gcccccctcc gggggccatg ctgaaccctc
     1441 cgtttccttt ccccctcccg gaaagcaggt tggggcaggg cctgatggaa tgtcacgcgc
     1501 taagttcctg gtttggcttc gcatatgaaa ttttccggtt tctgctccat tctccggaag
     1561 ccatccaggc ccggacggag gaaaatccaa aaaacgtatt tgctccggac cggaaacagc
     1621 cgcccctatc caccttcccc accccggaaa aacgctctca tccccatatg gctcccgggg
     1681 aaatatcctg aagcgactgt tgtccctgtg gacctctttc ccattcagga aaaacaatac
     1741 tccggaaaat aaaaaacccg gcgccgcctc acggcgggcc gggccagcaa aatagcaatt
     1801 cttccgatta ccggttggca gacttcacaa tcatggcatc cttgccgatg cggccgcgca
     1861 gatagtgaag tttggcgcgg cggactttgc cgcggttcac gacttcaatc ttggcaatgc
     1921 ggggagtatg cagggggaat acgcgttcca cgccttcacc gtaggaaatt ttgcggacgg
     1981 tgaaagcttc attgatgccg gaaccgcgct tggcgatcac aatgccctgg aaaatctgaa
     2041 tacgttcctt gccgccttca ataacacgag tgtgaacctt gatggtatca cctacgttaa
     2101 atggggtcac atccgccttg agttgctctt gctcgatttt gttgataatg ttcatcttgt
     2161 gttatctatt gctggtgaat atcagtaaaa ggaaaactta cgggacgcag aatatgagcc
     2221 ataatcccct aaaaggcaat ccaaatttgc cgtacgtcct taatttattt tttcggcggg
     2281 gccggaggcg gagccaccct ggcaagccat tcctccagcg ccggaagaaa agcggaggaa
     2341 gacatgaggc cccggatgcc gtccgcccgc tgcagaaagg ccttgttgcc gccccgggcc
     2401 cgttccgcca tcaggatttc cagcagcagg cgcgcgcggg tgcgggcgtc agccggcgcg
     2461 gaccggttcc ttccggtaca ggcattccag cgccagagct tcataaagac aggaaaaagg
     2521 ggccttccgg gcggactcca tcaaacgcgc ggaacggtcc ttccagcggt ctccgaactg
     2581 cacggaggaa gcccaccacc cctggaaata acggtcttct tccgtcggct ccacgtccat
     2641 atccttcatg cgggcgtatg gacggtacag ggggtctccg aacaccaccc cctgccagga
     2701 cagcacaggc atgctcatcc aggaagcctc cgccacggta tagccgtcca ggaggcggtc
     2761 cacaaaaata tcaaagcggt ggcaggcgcc caggaacggc tcatacacgt ttcccaccgt
     2821 cacagcagcc cccttctcca gcagggcgga actccacccc ctgccgggga ccttgaaatc
     2881 ggcggcgctg aaggaatgca gatgcatggc tatcgccccg ggccggaaac ggaacgaagg
     2941 atccgaaaac ggtccgttcg cattccccgc ataccaccca cagtaaagag ccgtatcccg
     3001 gctcaagggg aatttttccg gcaaggtctg gggccagtca tccagataag cgggaatgcc
     3061 cgcctccctc acgcgctcga acacgtcgtc cagccaccgg tccccctggg catagggacc
     3121 gccccggtcc acaacggccc acccccataa accttttttc tccacgttcg ccggttccgt
     3181 caccagccgc atgcaggtat cgggcgtcag tccgtccagg cggcatacca gaaacgaagg
     3241 aaggccggaa cccacaaaat cctccctttt attaaaatag ggattcacct gccaggactt
     3301 cctttcataa ccgcccaccg ccagcagagc caattcggaa tccaccgcag cgcgatccgt
     3361 ctgcatctgg ttgacgcctt tcccgggaag gagagcgggc gtttcatgcc gtatcttcat
     3421 cggcaggtcc gccatcagca ccagcacaaa aatcttccgg ttcatcaagg gggaggacgc
     3481 aatgccggaa ggcacccacc accgttgttt ccgcgccgtc tccagcagcg ggacgcggat
     3541 cgtatcctca tattccttcc gcgaaatctc gctggtcatg gggcaatcca gggaaacgag
     3601 attcccttcc ggaacgccgc gcacccgcgc atactccctg gccatgcggc ggctcagctc
     3661 ggattttccg ttataaatca cggccacatg agcgggcagc agctcatagg cacacgcggc
     3721 ggaaaaccac gacgccagca gaaataacac ggctaatcca ctcttgaaca tgcccctacc
     3781 atacctcatc ttccggggca atcaagcagg tgaaaggggc ggccacgaat tcgccatttt
     3841 tccgcttttc gcttcacatc ctaaaaaaat acgctttaat aactcttgat gtattgcagg
     3901 cctcccccct gcattcccta taaccatcac acgcatatga ttcagcaaat tgaccatatc
     3961 ggcatcgccg tcaagagtct tgacgccacc gtcccctatt accgcgatgc gctcgggctc
     4021 ggagagcccc acattgagga agttcccact caaaaggtcc gcgtcgccat gtttgacgtt
     4081 gccggagtcc acatcgaact gctcgaaccc acctctccgg aaagcgctat cgccaaggct
     4141 attgagaaaa aaggggaagg catccaccac atcgctttca agaccaatga catcgccgga
     4201 aatatctccc aggccaagga agcaggcctt accgtgctga acgacccgcc cgtccccggc
     4261 gctcacaaca cgcaggtcac cttcctgcat cccaagtgca ccttcggcgt cctgaccgaa
     4321 ttctgccagc accccggcag ctgcgaatgc ggcaagtaac attctcccta ttcaccatac
     4381 cactagacca atggctattg atcccaaatt gattgacgat ctgaacagcc gccgcaagaa
     4441 ggtcatcctc agcggcggtc aggaaaagat cgacaagaga catgaaaagg gcgaaatgac
     4501 agcccgcgac cgcatggggt acctctttga ggaaggcacc ttctcggaaa tcggcatgca
     4561 tgtgcgccac aactgccaca acttcggcat gggtaagaag gaaatccccg gcgacggcgt
     4621 cgtttccggt ttcggcctgg tggacggccg cccggtagcc tgcgcggcct ccgatttcct
     4681 ggcccagggc ggttccctcg gctacatgca cgccatgaaa attgcggatg ctcagaagta
     4741 tgctctgaaa gccggcatcc cgatggtgac cgtgaacgac tccggcggtg cgcgcctcca
     4801 ggaaggagtg gcggcccttt ccggatacgc ccaggtgttt tacaacaatg tgcttgcctc
     4861 cggcgtggtt ccgcaaatct ccatgatcct gggcccctgc gcgggcggcg cggcctactc
     4921 ccccgccctg acggacttca tcatcatgcg caattccggc aacgcgggca tgtacatcac
     4981 cggtcccaaa gtgattgaac aggtcacgta tgaaaaatgc acgatggacg acatcggctc
     5041 cgccgccatt cacgccaccg tgtccggcaa cgtccatttc gtagcggaca gcgacgcgca
     5101 cgccatggac atcctgaaga ggcttctttc cttccttcct tccaacaaca cggaagaacc
     5161 gccccacaaa ctggacactc cgctggacct gagcgctgac gaaggcatga gcgacctgat
     5221 tcccggcgac aaccgcacgc cgctggacgt ccagcccatc atcagccgtc tggtggacaa
     5281 cggggacttc ctggaagtac acaaggactt cgccaaaaat gtcgtcgtcg gattcggccg
     5341 catctgcggc gtggtggtcg gcatcatcgc caaccagccc aatgtgaaag ccggctgcct
     5401 ggatatcgat tcctccgaca aggccgcgcg cttcatccgc ttctgcaacg cgttcaatat
     5461 tccgttggtg aacctggtgg acgtacccgg cttcctgccc ggcaagaacc aggaacgggg
     5521 cggcattatc cgccacnnnn nnnnnncaaa cttatcttcg cctattccca ggccacggtg
     5581 cccaaagtca ccctgatcat gcggaaagcc tacggcggcg cctacatcgc catgtgctgc
     5641 aaggacctgg gtgctgacgc cgtcttcgcc tggcctggtg cggaaattgc cgttatgggc
     5701 gcggaaggcg ccgtcccggt actctacggc cgcgaactga aggctgtgga agacccggcg
     5761 gaaaaagcca agcgccaggg cgaacttctg gaagaatacc gggaagcctt ttacaacccg
     5821 tatgtggcgg ccggcatggg acagattacg gaagtcatca atccggaaga aacccgcgcc
     5881 aaaatcgcct tcgcactgcg caccctgctg aacaagaagg aagtgcgccc ggccaagaaa
     5941 cacggcaaca ttccgctcta acatccatcc caacggattc atatgttact tacaacactc
     6001 gcttttgcct tcgcacaggg catcgccaac gttatggaca atctgaatta tcaggttgtc
     6061 ggcatcatgg tggttatgct gtgcctggga ggcatggccg tcattctgac cgtcagcggc
     6121 tccatcgccg ccgccattca gaacagggcc aaagccaaaa cagccgctcc cgtagccgtg
     6181 cctgccgccg ctcccgctgc ggcgggcaaa ccgggcatga ctccggaaat gctcgccatc
     6241 ctttccgccg ccgtggattc cgccatgacg gagcttacgc cggaaatggt ggccgtcatc
     6301 tccgccgccg tggacgcagg cctagacggc atgagccacc gcatcgtgga aatcaagcaa
     6361 tccccgggtt ccggctatgc ggccgcgggc agggcggaaa ttttcgcctc ccaccgcatc
     6421 cggccttccc gctgaactac tgcattattc acccttaccc cgcccaggcg gaaccattta
     6481 acttaatatc ccataccaca cactattatg aagaaacttc gcatcaccgt agacggcaaa
     6541 gtatttgacg tatccgtaga acttctggac caggtgtcct ccaccactgc ggcgccggcc
     6601 cccgcacctg tggccgctcc cgctcctgcg gcttccgcac ccgtggccgc tccggtcccg
     6661 gctcccgcac ctgctccggc tccggctgcc gccggcgcag gagacgttcc cagcccgctt
     6721 gccgggaagg tcgtatccct ggacgtggca gcaggcaccc ccgtgaaggc cggtgaccag
     6781 attctgacgc tggaagccat gaagatgaac accatcatct acgctcccgc ctccggcacg
     6841 ctcaccgctt tctgcgtgaa cccgggcgac acggttcagg aaggacaggc actggccaaa
     6901 attggttaat cccggcggcg gcagcccgga aacgccaaca gtcccgggct ccggctcaga
     6961 taataaaccg ctacaaaaat attccctatg agtctttttg attcattaat caccttttta
     7021 caggggatgg gcgtcttctc cctatcatgg cagatggtag ggatgtgggg cattgccatt
     7081 ctcctcctgt atctgggtgt agccaagcaa tacgaaccgc tcctgatggt tcccattgct
     7141 ttcggcgccc tcattgccaa cattccggat aacggaatgc tcatcaccca gctgaaccag
     7201 caggtcatct cctccaatga acagggggaa gtaaccgcca cgtctctgaa caacgtgggg
     7261 tacctgcgcg ttcacgtggc tccgcttcag caggctccct ccaaggtgcc ggccaacctg
     7321 accacgcctg aatcccgttc ccagtatcag gaaatcatgc agcagcccat gcaggtttac
     7381 cctggcagcc agctgactgt ttccaagatc aagtccgtgc gggaatccca ggaaaaagca
     7441 aaagctgacg cggcccgtct gggcgacgac agcctgacgg tggaccccaa cctgaaggat
     7501 ttccagaacg tgacggaaga caacggcaat gaaccggtct tcctgctcac gaacggagaa
     7561 gggaccaccg tcgtccgcca gcagggcgtc aattactttg acaccagcgg caaccggatt
     7621 ccggtggatc tgaaaaccca gaagctggag cccctggtgg tttcagccgc aggcaaatac
     7681 gtggccgtag gccagcatac ccaggaactg ctggtcacct ccatccacgg gggcctgtat
     7741 gactggatcg ggctgggcat caaggctgaa attttcccgc ccatcatctt tctgggcgta
     7801 ggagccctga cggacttcgg cccgctgctt gccgctccgc gcaccctgct tctgggcgca
     7861 gcggcccagg tgggcgtagc cgccacgttc ttcatggccc tgttcatggg gttcaccccg
     7921 aatgaatccg cgtccatcgg catcattggc ggcgctgacg gccccacctc catcttcctg
     7981 acgatgaagc tggccccgca cctgctgggc gccgtggccg tggccgcata cacgtacatg
     8041 tccctggttc cgctgataca gccgcccatc atggcgttgc tgacgaccaa gaaggaacgc
     8101 ctcatccgca tgaaatccct gcgaacggtc agcaagagcg aaaaactgtt tttcgccgtg
     8161 ctggtaacca ttgtcaccat tttgctgatt ccggacgcat ccccgctgat cggcatgctg
     8221 atgcttggca acttcctgcg cgaatgcaag gtgacggaac gcctggttca ggcctcccag
     8281 aatgaaatca tcaacatcgt caccatcttc ctgggaacct ccgtggggct cacgatgcag
     8341 ggcgaccgct tcctgcagtc ggaaacgctg ctgatcatcc ttctgggtat cgtcgccttc
     8401 ggcgtggcaa cagcgggcgg agtgattgcc gccaagatta tgaacctcat ctggcgcaag
     8461 aatccggtca accccctgat cgggtccgca ggcgtctccg ccgtcccgat ggcagcccgc
     8521 gtctcccaca atgtgggcca gaagtacgac ccctccaact acctgctcat gcacgccatg
     8581 ggcccgaacg ttgcaggcgt gatcggcacc gcagtcatcg cgggctacta catcgccact
     8641 ctggcgaaat aaccagaatt gaaaattact cccggcctcg gcccgtccca tgaattccgc
     8701 agcctcattt tccacccctc cggaggagga aggaccatgc ggcgactgga cttatcatga
     8761 atgggccgag gctttttcca ccaatgatct ggcccgagcc ctccccccgg ggcatattgc
     8821 cgtctgccgc gttcagacag gaggccgcgg caggttcaac cgcaaatgga taggggagga
     8881 aggcggcctg tgggcatcct tcaccgtccc cctgtccgct cctgaggata cagcggccgg
     8941 cgtgcactgg ggccatttgc ccctggttgc ggggctggcc ctgttcaaca tgctccgcgg
     9001 catggggctg gattccgtgc gcctgcgctg gccgaacgac ctgctggcgg gcaaatccaa
     9061 actggcggga atactggtgg aacgcccagc ggagaacatg gccgtcatcg gcatcggcat
     9121 caatgttttc aatgatgtat cctccatcgc cggggaaatc aaggaccctc cggcaaggct
     9181 ggcggatctt gttcgggact gcccttccct gcacgccgtc atggcttccc tgggcagtca
     9241 tttgaaccag gttctttccg tcttttccca cggcggcgtc cccgcccttc aggaggatct
     9301 gtcccgggca tgggccggag aaaggccggt ttccattctt acggatgacg aaaccgtccg
     9361 gggcattttt acaggnnnnn nnnnnattga cgatcagggc aatcctgtgc tatcccttcc
     9421 ggccggcacc gtccgcacca ttccggcgca cctgatcaac aggctcctcg aagaatgagc
     9481 ctgccgctcc gttttacacg gggtttcttt cttttttcat ccaacaaaaa tcactgacat
     9541 gagttacaag gtactgacac cagaagaagc agcaagcctg atcaagcatg gccaccatat
     9601 tgggctgagc ggattcacgc ccgccggaac ggccaaggcc gttacggctg cgctggcaaa
     9661 aatcgcagaa gcggaacatg agaaggggaa ccctttccag gtgagcgtct tcaccggtgc
     9721 ttccactggc gattcctgcg acggaatcct ttcccgggcc aaggcaatcc gctaccgcgc
     9781 tccctacacc accaacgttg atttccgcaa ggcggtgaac aacggggaaa tcgcctataa
     9841 tgacatccat ttgtcccaga tggcccagga agtgcgctac gggttcatgg gcaacgtgga
     9901 catcgccatt attgaagcct gtgaagtcac ggccgacggc aaaatttacc tgacggccgc
     9961 gggcgggatc gctcccacca tctgccgcct ggcagacaaa attatcgtgg aattaaacgc
    10021 cgcccacagc aagagcgcca tgggcctgca cgacgtttac gaacccctgg atcctcccta
    10081 ccgccgcgaa atctccatct tcaaacccag cgaccgaatc ggcaagccgt acatccaggt
    10141 tgacccgaaa aagattgtgg gcattgtgga aaccaactgg ccggatgaag cccgttcctt
    10201 cgccgcagcg gatcccctga ccgataaaat cgggcagaac gtggccgatt tcctggctgc
    10261 cgacatgaaa cggggcatca ttccctccac gttcctgcct ctccagtccg gcgtaggcaa
    10321 catcgcaaac gcggtgctgg gcgccctggg ccgcgacaag acgattcccg cgttcgagat
    10381 gtacacggaa gtcatccaga attccgtcat cggcctgatt cgggaaggcc gcgtgaaatt
    10441 cggcagtgcc tgctccctga ccgtgacgaa cgactgcctg gaaggcattt acagggatat
    10501 ggactttttc cgcgacaaac tggtgctccg tccctcggaa atatccaaca gcccggaagt
    10561 tatccgccgt ctcggcgtca tctccatcaa caccgccatt gaagccgaca tttacgggaa
    10621 cgtcaactcc acgcacattg gcggcacgaa gatgatgaac ggcatcggcg ggtccggcga
    10681 cttcacgcgc aacgcctaca tctccatttt cacctgcccg tccgttgcca aggacggcaa
    10741 gatcagcgcc atcgtcccca tggtttccca ccatgaccat acggaacatg acgtcaatat
    10801 cattattacc gagcaggggg tcgcggacct gcgcggcaag agcccgaaag aacgggccca
    10861 gaccattatt gaaaactgcg tccacccgga ttacaaaaac atcctctggg attacctgaa
    10921 gctgtccgac ggcaaagccc agacaccgca atccatcagg gccgctttgg gcatgcacgc
    10981 cgaactggcc agaagcggag acatgaagaa tgtcgactgg gcccagtata agtaattccg
    11041 catgccgtca ttcgcattgg catccatgaa ttcacgttaa cctctcagga tcgcttccgc
    11101 aaagggagcg gtccttttcc tttttcccat cccctctact ccttctcttc accatgaact
    11161 ggatgattta cccggcagcc agggctttca tcaaagtctg cgccgttctt ttcggcgcgg
    11221 gcgcagcagc ggcagtcctc atccatctgt tcatgccttt tttcctccgc tctccccgga
    11281 cagccgcacc cttcctgctt ttgggcacag gggcggaatt gctctccatc ctttccctgt
    11341 ccttcctcat gttctggggc gccagagtcc tgctggcctc ccgcggaagc agaataacaa
    11401 gaaatctgag catgctggcc ttcctgcccg ccctgtacgc cctcctcatt ccgtttgcgg
    11461 gcatgcccgt cccatcgcaa tatacggaaa tggacagggt ttgggaggcc gtcctccttc
    11521 tggcggccgt cacttctttc ttttccttcc cttatacggc gctgcggttt gcagagcgcc
    11581 ctgttttttc ttgccgtcct gttgcgtcag ttcctgtcca ccgcagttcc ctccctggca
    11641 gcgcctgttg catggctggc cgttcttctg tcctgcggcc tggaaatcat gctggcggcc
    11701 ctttccgttc ttctggcgca gcgcctattt aaagaggtca tgtccatagc atccatgccg
    11761 gaaccgattg atccctccat gccgggcaac cgtccctgac tttcctatcc ctccgttttt
    11821 accggcctgc cggaagagta ccctcattcc ccggcatgaa aggcttttac ggcttcgcgc
    11881 aaaaagccgt ccggaaattt ccgccggtgg aacggaatcc gtatggaaag caacccgccc
    11941 caccccggaa agccgcaggg tcgcagggac acccctcccg tttccatacc ggcggcagac
    12001 aaccctattt caccaattca tccagataac ggccataacc gttattattc atggctccgg
    12061 cctgggagcg cagcatttcc tgggaaatcc agccgttatt aaaggctatc tcctccaggc
    12121 aggctacctt gaacccctgg tggtgctcca gagtacgaac gaacatggaa gcctccagaa
    12181 gggtatcgtg cgtgcccgta tccagccacg tatagccgcg cgccagtttt tccacgcgca
    12241 acagaccctg cttcaggtat tcctgattca cagaggtgat ttccaactcg ccgcgggaag
    12301 acttgggaat ccgtttggct atctccacca cccggttgtc gtaaaaatag aggcccgtca
    12361 ccgcaatatc cgatttgggc ctgagcggtt tttcctcaat ggaaaccgcc ttcccctcct
    12421 cattgaattc cactaccccg aaacgctgcg ggtcatgcac ctggtaaccg aaaatggtcg
    12481 ctccgctcgt cagttcggcg gccctcctca gcttctccgt caggccgcgc ccgtaaaaaa
    12541 tattgtcccc cagcaccagg gcaacggaat cctttcctat gaactcctct ccaataataa
    12601 aggcctgagc cagcccctcc ggcctgggtt gttccctgta ttcaaaggaa acgccgaacc
    12661 tgctgccgtc ccccagcaaa tcccggtaca gaggcagatc ccggggcgtg gaaataacaa
    12721 ggatttcccg tatcccggcc agcatcagca cggagatggg ctaataaacc atcggcttat
    12781 cgtaaacggg cagcaattgc ttgctgacgg aaagcgtgac gggatgcagc cgcgtgccgc
    12841 ttcccccggc cagnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    12901 nnnnnnnnnn nnnnnnatca aattcctagc cattggttcc aagacgttcc aggcggtatt
    12961 ccccggacag gatgccccgc caccattcct catggtccag ataccactga atggtctttc
    13021 tgaatccgga agaatggtcc tggcgcggag tccaccccaa ttccctccgt attttggaag
    13081 cgtcaatcgc atagcgcagg tcatggcccg gcctgtcctg cacaaaggag atttgctccc
    13141 ggtagctccg gccgtccgga cggggccgca gttcatccag atgggaacac agcagctcca
    13201 ccagctccag attggttttc tcgttattgc cgccgatgtt gtacgtttcc cccggttttc
    13261 cgcaggaaac gaccgtcaac agcgcctcgc agtgatcccc cacatacagc cagtcccgca
    13321 cgttttcccc tttgccgtat acaggaatgg gttccccgcc cagcgctttc aggataacga
    13381 cgggnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    13441 nnnnnnnnnn nnnnnnnnnn nnnnttggaa cagttggtga tcagcacggg cagcccgtac
    13501 gtatcgtgcc aggcgcgcac caggtggtcg ctggaggcct tgctggcgga atacggggaa
    13561 tgggggcgat acggcgtgga ctccgtgaac aggccttcct ttcccaggga gccgtacact
    13621 tcatccgtgg aaatgtgatg aaagcggaaa cgctcctttt tctctccctc cagggaacgg
    13681 taatattcta
//
