LOCUS       c00019_gnlPro..        14347 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KFNOENJD_19.
ACCESSION   c00019_gnlPro..
VERSION     c00019_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 15:17:00
            Original ID  :: gnl|Prokka|KFNOENJD_19
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14347
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..735)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_M"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_1"
                     /sec_met_domain="Proton_antipo_M (E-value: 1.6e-24,
                     bitscore: 76.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFLSLFVLIPLLMLLGLWLSRNIAQIRAVMVTGASALLVLSAAL
                     TVMYLNARHAGATDEMLFRADMVWYPALNIHYSVGVDGISVAMLLLSAIIVFTGTFASW
                     RLQPLTKEYFLWFTFLSIGVFGFFISIDLFTMFMFYEVALIPMYLLIGVWGSGRKEYSA
                     MKLTLMLMGGSAFLLIGILGIYYGAGATSMNLLEIAQMHNIPIEQQRIWFPLTFLGFGV
                     LGALFPFHTWSPDGHASAPTAVS"
     protocluster    1..14347
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:7921]"
                     /cutoff="10000"
                     /detection_rule="(Oxidored_q4 and Oxidored_q6 and
                     Complex1_30kDa and Complex1_49kDa and NADHdh and
                     Oxidored_q3 and Oxidored_q2 and minimum(4, [Fe-2S_thioredx,
                     Fer2_4, Fer4_7, Molybdop_Fe4S4, Molydop_binding,
                     NADH-G_4Fe-4S_3, NADH_4Fe-4S, Proton_antipo_M,
                     Proton_antipo_N, SLBB]))"
                     /neighbourhood="10000"
                     /product="NADH_dehydrogenase_I"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..7921
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Oxidored_q4 and Oxidored_q6 and
                     Complex1_30kDa and Complex1_49kDa and NADHdh and
                     Oxidored_q3 and Oxidored_q2 and minimum(4, [Fe-2S_thioredx,
                     Fer2_4, Fer4_7, Molybdop_Fe4S4, Molydop_binding,
                     NADH-G_4Fe-4S_3, NADH_4Fe-4S, Proton_antipo_M,
                     Proton_antipo_N, SLBB]))"
                     /neighbourhood="10000"
                     /product="NADH_dehydrogenase_I"
                     /protocluster_number="1"
     cand_cluster    1..14347
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Oxidored_q4 and Oxidored_q6 and
                     Complex1_30kDa and Complex1_49kDa and NADHdh and
                     Oxidored_q3 and Oxidored_q2 and minimum(4, [Fe-2S_thioredx,
                     Fer2_4, Fer4_7, Molybdop_Fe4S4, Molydop_binding,
                     NADH-G_4Fe-4S_3, NADH_4Fe-4S, Proton_antipo_M,
                     Proton_antipo_N, SLBB]))"
                     /kind="single"
                     /product="NADH_dehydrogenase_I"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14347
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NADH_dehydrogenase_I"
                     /region_number="1"
                     /rules="(Oxidored_q4 and Oxidored_q6 and Complex1_30kDa and
                     Complex1_49kDa and NADHdh and Oxidored_q3 and Oxidored_q2
                     and minimum(4, [Fe-2S_thioredx, Fer2_4, Fer4_7,
                     Molybdop_Fe4S4, Molydop_binding, NADH-G_4Fe-4S_3,
                     NADH_4Fe-4S, Proton_antipo_M, Proton_antipo_N, SLBB]))"
                     /tool="gutsmash"
     CDS             complement(787..2700)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Proton_antipo_M"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_2"
                     /sec_met_domain="Proton_antipo_N (E-value: 1.5e-25,
                     bitscore: 79.0, seeds: 433, tool: rule-based-clusters)"
                     /sec_met_domain="Proton_antipo_M (E-value: 7.1e-86,
                     bitscore: 277.8, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYTILILLLPFLSFLALGLGGKWMSHRTAGLIGTAALGVVAVLS
                     YLTAGMYFSAPRLADGTYEALMPYNFKWLPFTESLSIDMGILLDPISVMMLVVISTVSL
                     LVHIYSFGYMKGERGFQRYYAFLSLFTMSMLGLVVATNIFQMYLFWELVGVSSYLLIGF
                     YYTKPAAIAASKKAFIVTRFADLGFLIGILVYGYYAGTYTFSPNEMALAKGGAAMIPLA
                     LGLMFIGGAGKSAMFPLHIWLPDAMEGPTPVSALIHAATMVVAGVYLVARMFPLFIEYA
                     PSVLHIVAYVGAFTAFYAASVACVQSDIKRVLSFSTISQIGFMMVALGVCTSADPHEGG
                     LGYMAGMFHLFTHAMFKALLFLGAGSIIHAVHSNEMSAMGGLRKYMPITHITFLIACLA
                     IAGIPPFSGFFSKDEILTACFQFSPIMGWIMTVIAGMTAFYMFRLYYGIFWAGSEPGQK
                     SASDGGDSHMPHPHESPLAMTLPLMLLAVVTIVAGFIPFGHFISSNGEAYNIHLDWSVA
                     GTSIAVAVVSIAIATYIYAGSRQPVADTLAHRFKGLWTAAYHRFYLDEVYQFITHRIIF
                     GCICRPIAWWDRHVVDGFFDFLAWGADATSDEIRGLQSGRIQQYTFVFLLGTLALILLL
                     LL"
     CDS             complement(2759..3067)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_3"
                     /sec_met_domain="Oxidored_q2 (E-value: 1.1e-22, bitscore:
                     69.7, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHMEYYLIVSAIMFFAGIYGFFTRRNTLAILISIELILNATDIN
                     FAVFNRFLFPGGLEGYFFSLFSIAISAAETAVAIAIMINIYRNIRSIQVNKLDEMKW"
     CDS             complement(3073..3585)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_4"
                     /sec_met_domain="Oxidored_q3 (E-value: 1.3e-34, bitscore:
                     108.9, seeds: 708, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEITLETVVFYFLAAFITVFSILTVTTHPMVRSATYLLFVLFGTA
                     GIYFLLGYTFLGSVQIMVYAGGIVVLYVFSILLTSGEGDVIEKLKRSRFLAGLGATVGG
                     AIIVVFITLKHKFIATTDVEPLEVNIKTIGHHMLSGDKYGYLLPFEAVSILLLACIVGG
                     LLIARKR"
     CDS             complement(3616..4119)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1020:4Fe-4S binding domain (Score: 30.2; E-value:
                     8.7e-10)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_5"
                     /sec_met_domain="Fer4_7 (E-value: 3.7e-13, bitscore: 39.9,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 9.5e-06, bitscore: 16.1,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKNSYIGGLIHGVTSLLTGMKTTMTVFCRRKTTEQYPENRSTL
                     KLSDRFRGTLTMPHNDKNEHRCVACGLCQMACPNDTIKVTGEMVETEDGKKKKILVKYE
                     YDLGSCMFCQLCVNACPHDAITFDQDFEHAVFDRTKLVMTLNRPGSHVEEKKKPAAPKE
                     ETTK"
     CDS             complement(4177..5262)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: NADHdh"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_6"
                     /sec_met_domain="NADHdh (E-value: 7.5e-121, bitscore:
                     392.8, seeds: 435, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNVFDFSIVTNWIHQMLTSLMPEGLAIFLECVVIGVCIILMYAV
                     LAIILIYMERKICAFFQCRLGPMRVGKWGLLQVPCDVIKMLTKEIINLKFSDRFLYNLA
                     PFMVIIASFLTFACLPINKGLEVLDFNVGVFFLLAASSIGVVGILLAGWSSNNKFSLIG
                     AMRSGAQIISYELSCGLSILTMVVLMGTMQFSEIVEGQADGWFIFKGHIPALIAFIIYL
                     IAGNAETNRGPFDLPEAESELTAGYHTEYSGMGFGFFYLAEYLNLFIVASVAATIFLGG
                     WMPLHIVGLDGFNAVMDYIPGFVWFFGKAFFVVFLLMWIKWTFPRLRIDQILNLEWKYL
                     VPISMVNLILMVLIVVFKLHF"
     CDS             complement(5394..6983)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Complex1_30kDa"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Complex1_49kDa"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_7"
                     /sec_met_domain="Complex1_30kDa (E-value: 5.2e-36,
                     bitscore: 113.9, seeds: 586, tool: rule-based-clusters)"
                     /sec_met_domain="Complex1_49kDa (E-value: 2e-82, bitscore:
                     266.1, seeds: 265, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIKYIEPSVLHDEMLRLRKEKQMDFLECLSGMDWGIPDEKDAPD
                     TPRGLGVVYLLESTVTGERIAVRTATLNREHPELPSVSDIWKAADFNEREVYDFYGIVF
                     IGHPDMRRLYLRNDWVGYPMRKDNEPEKDNPLRMDNEETVDTTMELELNPDGSIKNKEM
                     QLFGDEEYVVNIGPQHPATHGVMRFRVSLEGEIIDKIDANCGYIHRGIEKMCESLTYPQ
                     TLALTDRLDYLGAHQNRHALCMCIEKAMGVEVSERVQYIRTIMDELQRIDSHLLFYSCL
                     AMDLGALTAFFYGFRDREKILDIFEETCGGRLIMNYNTIGGVQADIAPGFVKKVKEFIP
                     YLRGILHEYHDVFTGNIIAQQRLKGVGILSREDAIAFGATGGTGRASGWACDVRKRMPY
                     AVYDKVDFKEVIRTEGDSWARYLIRMDEILESLKIIEQLIDNIPEGAYQEKMKPIIRVP
                     EGTYYAAVEGSRGEFGVFLESHGDKMPYRLHFRSTGLPLVSTVNTICRGAKIADLIAIG
                     GTLDYVVPDIDR"
     CDS             complement(6999..7580)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q6"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_8"
                     /sec_met_domain="Oxidored_q6 (E-value: 2.7e-26, bitscore:
                     81.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVTKKPKIKSIPYEEFTDNETLEKLVRELNAGGANVALGVLDDF
                     VNWGRSNSLWPLTFATSCCGIEFMALGAARYDMARFGFEVARASPRQADMIMVCGTITN
                     KMAPVLKRLYDQMADPKYVVAVGGCAVSGGPFKKSYHVVNGVDKILPVDVYIPGCPPRP
                     EAFYYGMMQLQRKVKIEKYFGGVNRKEENH"
     CDS             complement(7571..7921)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NADH_dehydrogenase_I: Oxidored_q4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_9"
                     /sec_met_domain="Oxidored_q4 (E-value: 6.8e-39, bitscore:
                     122.0, seeds: 391, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFTLLVVVLLTAIAFVGIVIALSNAIAPRSYNAQKMEPYECGIP
                     TRGKSWMQFRVGYYLFAILFLMFEVETVFLFPWAVITRELGVAGLFSVLFFLIILILGL
                     AYAWRKGALEWK"
     CDS             complement(8032..8355)
                     /locus_tag="ctg19_10"
                     /transl_table=11
                     /translation="LHDSATGAVDILCVPATRQAECCTLSQAPTTQQAVQKFYDLFSPN
                     SLCIEHVDHTQVPTNKNVLLRMYIYKMQQHAYAPECDRLLNLSPHPVPDANYYVFGLRK
                     III"
     CDS             complement(8507..9958)
                     /locus_tag="ctg19_11"
                     /transl_table=11
                     /translation="MINFKTIIRIIGILLLLETVMFLVCSGVSFYYRESDMLDFWKAGG
                     ITAGVGLLLAALGKGGERQLTRRDGYVLVSFAWVAFSLFGMLPFYIGRYIPDIANAFFE
                     TMSGFSSTGATILDDIESLPHGILFWRSMTQWIGGLGIIMFTIAVLPIFGVSGLQVFAA
                     EASGPTHDKVHPRIGITAKWIWSIYAGITALLVSLLMLGGMDWFDSICHAFATTGTGGF
                     STKQASVSYYNSPYIEYVISIFMFISGINFTLLLLFVNRKFKKFISNAELKFYFGSVVL
                     FTAVIAIVLYYTSPMGMEESFRKSLFQVISLHTSTGFATDDYMQWTPVLWGLLTIIMLM
                     GACAGSTTGGLKCIRMVILTKVSRNEFKHILHPNAILPVRINKQVISPSIVSTVLAFCF
                     IYIAIIVIGTLLMMAMGVGAEESMGCVISSIGNMGPGLGETGPAYSWNALPDAAKWLLS
                     FLMLLGRLELFTVLLLFTPDFWKRN"
     CDS             complement(9980..11320)
                     /locus_tag="ctg19_12"
                     /transl_table=11
                     /translation="VKIIIAGAGAVGTHLAKLLSREKQDIILMDDNEDKLSTLNSNFDL
                     MTATASPTSIKGLKEVGVGEADLFIAVTPDESRNMTACMLANNLGAQKTVARIDNYEYL
                     LPKNKEFFQKLGVDSLIYPEMLAAKEIVSSIRMSWVRQWWEFCGGALILIGTKMREKAE
                     ILNIPLHELGGPELPYHVVAIKRGSETLIPRGDDTIKLHDIVYFTTTRKYVPYIRKIAG
                     KEDYADVRNVMIMGGSRIAVRTAQYVPDYMQVKSVDNDLNRCNRLTELLDDRTMIINGD
                     GRDMDLLVEEGLKNTEAFVALTGNSETNILACLAAKRMGVSKTVAEVENIDYIGMAESL
                     DIGTVINKKMIAASHIYQMMLDADVSNVKCLTFANADVAEFTVKAGSKITKHPVKDLGL
                     PKGATIGGLIRQGEGVVVMGNTLIQPGDHVVVFCLNMMIKKIEKYFN"
     CDS             complement(11409..13544)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transket_pyr"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_13"
                     /sec_met_domain="Transketolase_C (E-value: 1.5e-25,
                     bitscore: 79.4, seeds: 80, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.8e-08, bitscore:
                     23.6, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Transket_pyr (E-value: 2.5e-34, bitscore:
                     108.4, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVERFFPQDGTIFSPWRNDLLSGIFSLNHRQAEREMWRMQRESKN
                     RSEQKRLFFLLKLPAIRFLLLFLHFVIFRLEMRTEPTTYNLLNTITFPEDLRQLSVEEL
                     PEVCKELRQDIIKEVSCNPGHFAASLGTVELTVALHYVFNTPYDRIVWDVGHQAYGHKI
                     LTGRREAFSTNRKFKGVRPFPSPEESDYDTFTCGHASNSISAALGMAVAAAEKGEKDRH
                     VVAVIGDGSMSGGLAFEGLNNASSTPNNLLIILNDNDMSIDRSVGGMKQYLFNLTTSNR
                     YNQLRFKTSRLLFKMGLLNEDRRKALIRFANSLKSMAAQQQNIFEGMNIRYFGPINGHD
                     VKNIARVLRDIKDMQGPKILHLHTVKGKGFEPAEKNPDIWHAPGKFDPETGERLKADTS
                     NLPPLFQDVFGETLVELAKENPKIVGVTPAMPTGCSMNKLMDTMPDRAFDVGIAEGHAA
                     TFSGGMAKEGMQPFCNIYSSFMQRAYDNVIHDIALLRLPVVLCLDRAGLVGEDGPTHHG
                     VFDLAYFRPIPNLTISSPMDEHELRRLMYTAQLPDQGPFVIRYPRGRGVLLDWKCPLEE
                     IPVGKGRKLKEGKDLAVISLGPIGNVAARAIERAEKDKGISIAHYDLRFLKPLDEALLH
                     EVGLNFQHVVTIEDGVKKGGMGSAVLEFMADNDYIPHIRRIGVPDAFIEHGTIQELYHL
                     CEMDEEGIYTLLIKNEE"
     CDS             13887..14345
                     /locus_tag="ctg19_14"
                     /transl_table=11
                     /translation="MKKKLDFKVLAIMGVVVFSACGSDSDLFNPEKAAAKKEAQYASAF
                     VQRYGEIAVDQDWGFGVTPTTRVANTNSNQWKDFTEVPGSVTATEKEVVTEWFKTYRNP
                     QSIGGDWTDFFVQHVSGSHSNMDFLVAASDDHINNFNATEGAIMLMQNS"
ORIGIN
        1 ggatacggca gtcggtgcgg aggcgtgacc gtcggggctc catgtgtgga acgggaacag
       61 agcgcccagc acaccgaaac cgaggaaagt gagcgggaac cagatacgtt gctgttcgat
      121 gggaatattg tgcatctgtg ctatttccaa tagattcata gaggtggctc cggcaccgta
      181 gtagataccc aagataccga taagcaggaa ggcagagccg cccatcagca tcagtgtcag
      241 cttcatggca gagtactctt tgcgtcccga cccccataca ccgataagca gatacatggg
      301 aataagggca acctcgtaga acatgaacat ggtgaacagg tctatcgaga tgaagaaccc
      361 gaacacaccg atggaaagga aggtgaacca aaggaaatat tctttagtca gcggttgcag
      421 cctccaggag gcgaatgttc cggtaaagac aatgatggcc gaaagcagca gcatggctac
      481 cgaaataccg tctactccta ccgaatagtg gatgttgagt gcaggatacc agaccatgtc
      541 ggcacggaac agcatttcat ccgtggcacc agcgtggcgt gcattgaggt acatcacggt
      601 caatgccgca gaaagaacca gcagagccga tgcaccggtc accatcaccg cgcgtatttg
      661 tgcgatgttg cggctgagcc aaagacccag cagcatcagc aaggggatga gtacaaataa
      721 tgataaaaag ttcatcttta tatttacgat ttaacgattt acgatttacg attgaaaaat
      781 ttcgggttat agcaatagta gcagtatcag tgccagcgtg cccagcagga atacaaatgt
      841 atattgctgg atgcgtccgc tctgcagacc gcgtatctcg tcactggtgg catcggcgcc
      901 ccaagcaagg aagtcgaaga agccgtccac tacatggcgg tcccaccagg cgatggggcg
      961 gcagatgcag ccgaagatga tgcggtgggt gatgaactgg tagacctcgt ccagatagaa
     1021 gcggtggtaa gctgctgtcc acaagccttt gaaacggtgt gccaatgtat cggcaacggg
     1081 ctgtcggcta cctgcataga tgtaggtggc aatggctatg gaaaccaccg ctacggcgat
     1141 acttgtacct gccacactcc agtccagatg gatgttatat gcttcaccgt tggaactgat
     1201 gaagtgtccg aaaggaatga aaccggcaac tatcgtaacc acggcaagga gcatcagggg
     1261 cagggtcatc gccagaggac tctcgtgggg gtgaggcatg tggctgtcgc ccccatcgct
     1321 tgccgacttt tgccccggct ctgagccggc ccaaaagata ccataataaa gacggaacat
     1381 atagaatgct gtcatacctg caatcactgt cataatccat cccatgatgg ggctgaactg
     1441 gaagcatgcc gtcaggattt catctttgga gaagaatccg gagaacggag gaatacctgc
     1501 aatggcaagg caggcgatga ggaacgtgat atgcgtaatg ggcatatact tccgcagtcc
     1561 acccatggca gacatctcgt tgctgtgtac ggcatggatg atgctacccg ctccgaggaa
     1621 cagcaatgcc ttgaacatgg cgtgtgtgaa caagtggaac atgcctgcca tgtagcccag
     1681 tcccccttcg tgtgggtcgg ctgatgtaca tacacccagc gccaccatca tgaaaccgat
     1741 ttgggagatg gtggagaatg acagtacacg cttgatgtca ctctgcacac atgccacact
     1801 ggcggcatag aatgccgtga aggctcctac gtatgccacg atgtgcagca cgctgggagc
     1861 atattctatg aacaacggga acatgcgtgc caccagatag acacctgcaa ccaccattgt
     1921 ggcggcatga atcagtgcac tgaccggcgt aggaccttcc atggcatcgg gcagccagat
     1981 gtgcaacggg aacatggcac tctttccggc accaccgatg aacatcagtc ccaaggcaag
     2041 cggaatcatt gccgcaccgc cctttgccag cgccatctca ttagggctga aggtgtatgt
     2101 accggcataa tacccataga cgaggatacc tataaggaat cccaggtcag caaaacgggt
     2161 cacgataaaa gccttcttcg aagcggcaat agccgccggc ttcgtataat agaaaccaat
     2221 cagcagatag gaggacacgc ccaccaactc ccagaacaga tacatctgga agatattcgt
     2281 tgctactacc agtccgagca tggacatggt gaagagcgac aggaaggcgt agtaacgctg
     2341 gaaaccgcgt tcgcccttca tgtagccgaa agagtatatg tgtaccagca gcgaaacggt
     2401 actgatgacc acgagcatca taaccgaaat cgggtcgagt aggataccca tgtcgatact
     2461 gaggctttct gtgaaaggca gccatttgaa gttatagggc atcagcgcct cgtacgtacc
     2521 atcggcaagg cggggagcgc tgaagtacat tcctgcggtg agataggaaa gcactgcgac
     2581 cacacccagt gccgcagttc cgataaggcc ggcagtgcgg tgtgacatcc atttacctcc
     2641 aagtcccaga gcgaggaaag agaggaaagg gagtagaagg attaatattg tatattccat
     2701 atatactatg tttatcaatt attactattc aagaaacatc gcttggcgat tcttgctctt
     2761 accacttcat ctcatccagt ttgttcacct ggatactgcg gatgttacgg tagatgttaa
     2821 tcatgatggc aatggctaca gccgtttcgg ccgccgagat ggcgatggag aataaagaga
     2881 agaaatatcc ttccagtcct ccggggaata ggaaacggtt gaacaccgca aagttgatgt
     2941 ccgtggcatt cagaatcagc tcgatgctga taagtatcgc cagcgtgttg cggcgggtaa
     3001 agaacccgta gatgcctgcg aagaacatga tagccgaaac tatcagataa tattccatgt
     3061 gtatcataat tcttatcttt tacgtgctat taataatccg cctacgatac atgccaataa
     3121 caagatgctg acagcttcga agggaagcag ataaccatac ttgtcaccgc tcagcatgtg
     3181 gtgaccgatg gtcttgatgt tgacctccaa aggttccacg tcggtggtgg caatgaactt
     3241 atgcttcaaa gtgatgaata ctacgatgat ggcaccgccc acggtggcac ccagtccggc
     3301 aaggaacctg ctacgcttta acttctcgat gacatcgcct tcgccactgg taagcagtat
     3361 ggagaagacg tagagcacta cgataccgcc ggcatagacc ataatctgca cggaaccgag
     3421 gaaggtgtaa cccagcagaa agtagatgcc tgccgtaccg aaaagcacga acagcaggta
     3481 ggtggccgag cgcaccatgg ggtgggtcgt taccgtcaag atggaaaata cggtgataaa
     3541 ggccgcaagg aagtagaata ctactgtttc aagagttatt tccatgttgt ttaattacaa
     3601 gttactatta acgaattact ttgttgtctc ttctttggga gcagcgggtt tctttttttc
     3661 ttctacatgg ctgcccggac ggttcagcgt catgaccagt ttcgtgcggt cgaacactgc
     3721 atgctcaaaa tcctggtcga acgtgatggc atcgtgaggg caggcattca cacagagttg
     3781 gcagaacatg cacgaaccga ggtcgtattc gtacttaacc aatatcttct ttttcttgcc
     3841 gtcttccgtt tcaaccatct cgccggtcac cttgatagtg tcgttgggac aagccatctg
     3901 gcacaaaccg caagctacac accgatgttc atttttatca ttatggggca tggtcagcgt
     3961 gccacggaaa cggtcggaga gtttcaatgt cgagcggttt tccggatatt gttcggtagt
     4021 ctttcgtcgg cagaatacgg tcatggttgt cttcatacct gtcagcagag aagtgacgcc
     4081 gtgtatgagt ccgccgatat aagagttctt ttctttcatt acttttgcct ttattaaaat
     4141 tatccgcaag gaaatcttgc tccggcgcta cgccggttag aaatgcaatt taaatactac
     4201 aattaatacc atcaaaatca agttcaccat agagatgggt accaggtact tccactccag
     4261 attcagaatc tggtcaatac gcaggcgggg gaaggtccac tttatccaca tcagcaggaa
     4321 gactacgaag aaggcctttc cgaagaacca tacaaatccc ggaatgtaat ccatcactgc
     4381 gttgaagccg tccaggccta cgatgtgtag cggcatccag cctcccagga agatggtggc
     4441 tgccacggag gctacgataa acagattcaa atattctgcc agatagaaga atccgaagcc
     4501 cataccgctg tattccgtat ggtatccggc agtcaactcg ctttcggctt cgggcaagtc
     4561 gaagggaccg cggttggttt ccgcatttcc ggcaatgagg tagatgatga aggctatcaa
     4621 tgcagggata tgtcccttga agatgaacca gccgtcagct tgtccttcta ctatttcgga
     4681 gaactgcatg gttcccatca acactaccat tgtcagtatg ctcaatccgc aggacaactc
     4741 gtagctgata atctgcgcac cgcttcgcat ggctccaatc agcgagaatt tattgttgga
     4801 actccagcct gccagcagga tacccactac gccgatactc gatgcagcca gcaggaagaa
     4861 cactcctaca ttgaagtcca atacctccaa tcccttgttg atgggcaggc aggcaaatgt
     4921 caggaaagaa gcgatgatta ccatgaacgg tgccagattg tagaggaacc ggtcagagaa
     4981 tttcaaatta atgatttcct ttgtcaacat cttgatgacg tcgcagggca cttggagcaa
     5041 tccccatttc cccacgcgca tcggaccgag gcggcattgg aagaaggcgc atatcttacg
     5101 ctccatgtaa atcaggatga tggcaagcac ggcatacatc aagatgatgc atacgccaat
     5161 caccacgcat tcgaggaata ttgccagtcc ttccggcatc agggaagtca gcatctggtg
     5221 tatccagttg gttactatac taaagtcaaa cacgttgttc atttactatt tacaatttac
     5281 tatttacaat ttacgaggcg ctttttgatt tacaattcac aatgtacaat ttacaatttg
     5341 gctgcgctgt aattccgcat ggtaaattgt aaattgtcaa atcgtaaatc cttttatctg
     5401 tcaatatctg gtactacata atccaatgtt ccgccaatgg caataaggtc ggcgatttta
     5461 gctccgcggc aaatcgtatt tacggtcgat accaatggca agcccgtact gcggaaatgc
     5521 aggcggtaag gcatcttgtc gccgtggctt tcgaggaaga cgccgaactc accgcggcta
     5581 ccttctacgg ctgcataata agtgccttcc ggtacgcgga taataggttt catcttttcc
     5641 tggtaggctc cttccgggat gttgtctatc agttgctcga taattttcag gctctccaga
     5701 atttcatcca tacgaataag gtagcgtgcc catgaatcgc cttcggtgcg gatgacttct
     5761 ttaaagtcca ccttgtcata tacggcatat ggcatacgct tacgcacgtc gcaggcccat
     5821 ccgctggcgc gtccggtgcc tccggtagct ccaaaggcga tggcatcttc ccgtgagagt
     5881 atacccacac ctttcagacg ttgctgggca atgatgttcc cggtgaatac gtcgtgatat
     5941 tcgtgtagga taccgcggag gtaggggata aactccttca ctttctttac gaagccggga
     6001 gcaatgtctg cctgcacgcc accgatggtg ttgtagttca tgatgaggcg tccaccgcaa
     6061 gtttcctcaa agatgtcgag tatcttttcg cggtcgcgga aaccgtagaa gaaggccgtt
     6121 aatgcaccca ggtccatagc aagacaagaa tagaacagca ggtgagagtc tattcgctgc
     6181 aactcgtcca tgatggtacg tatgtactgc acgcgttcgc ttacttccac gcccattgcc
     6241 ttttcgatac acatgcacaa ggcatggcgg ttctggtgtg cgcccaggta gtccagacgg
     6301 tcggtcagag ccaaggtctg cggataggtc aggctttcgc acatcttctc gataccccgg
     6361 tggatgtagc cgcagttggc atcaatcttg tcgatgattt caccctccaa tgatacacgg
     6421 aaacgcatta cgccgtgggt ggccggatgt tggggaccga tgttcaccac atattcctca
     6481 tcaccgaaaa gttgcatctc cttattcttg atgctaccgt cgggattcag ctccaattcc
     6541 atggtagtgt ccaccgtttc ttcgttgtcc atacgcaacg gattatcttt ttccggctca
     6601 ttgtctttac gcatgggata gcctacccag tcattgcgca gatagagtcg gcgcatatcc
     6661 ggatgaccaa tgaaaacgat gccgtaaaag tcgtagactt cgcgctcgtt gaaatccgca
     6721 gctttccaga tatcgctgac ggaaggaagt tcgggatgtt cccggtttag agtggcggtg
     6781 cgtaccgcta tccgttcgcc ggtaacagta gattccaaca gatagactac accgagtccg
     6841 cggggggtgt ccggtgcgtc tttctcgtcg ggtattcccc aatccatacc gctgaggcat
     6901 tccaggaagt ccatttgttt ctctttccgc agacgcagca tttcgtcgtg taggactgag
     6961 ggctctatgt attttatttc catattttta agtactgatt agtggttctc ttcttttctg
     7021 tttactccac cgaagtattt ctctattttc actttacgct gcaattgcat catgccgtag
     7081 tagaatgctt ccggacgcgg agggcaaccg ggaatgtaga catccaccgg cagaatcttg
     7141 tccacaccgt tcaccacgtg ataggatttc ttgaacgggc ctccgctgac ggcacagccg
     7201 cctacggcta ctacatattt cggatcggcc atctggtcgt aaagacgttt cagaacggga
     7261 gccatcttgt tggttattgt tccgcaaacc ataatcatgt ctgcctggcg cggactggca
     7321 cgggctacct cgaacccgaa gcgcgccata tcgtagcggg ctgcgccgag ggccatgaat
     7381 tcgataccgc aacagctggt tgcaaacgta agaggccaca gtgagttgct gcgtccccag
     7441 ttgacgaagt cgtccagtac gccaagggcg acattggcgc ctccggcatt aagttcccga
     7501 accagtttct ccaacgtttc gttgtctgta aactcctcat aagggataga tttaattttc
     7561 ggcttctttg ttacttccat tccaaagctc ctttcctcca ggcataagca aggcccagaa
     7621 tcaatataat caggaaaaat aaaacactga aaagtcctgc cacgccaagt tcgcgggtga
     7681 tgactgccca agggaacaga aataccgttt ccacttcgaa catcaggaac aagatggcaa
     7741 acagatagta acctacccgg aattgcatcc acgatttacc gcgggtaggg ataccacact
     7801 cgtacggctc catcttctgt gcattgtacg aacggggtgc tatcgcattg gagagcgcga
     7861 tgacgatacc cacgaaagcg attgccgtca ataagacgac cactaacaaa gtaaagttca
     7921 taaacctgat aagattttag atatataata atagatacat cgcaccggag gacaaaacct
     7981 ctgaattgtt gtccggcgag ttaggggcaa gcgtctgcgc ttgcaggcct tctaaatgat
     8041 aatctttctt agcccgaaca cgtaatagtt cgcgtcgggt acgggatgcg gagacagatt
     8101 caacaaacgg tcgcattccg gtgcataggc atgctgctgc atcttgtaga tgtacatgcg
     8161 caggagtacg tttttgttgg ttggtacttg cgtatggtct acatgttcta tgcagaggga
     8221 gtttggtgaa aacaagtcgt agaacttctg gactgcttgt tgggtggtag gagcttgtga
     8281 cagcgtgcag cattctgctt gtcgggtggc aggaacgcac aaaatgtcta cagctccggt
     8341 tgcactgtcg tgcaataggg ctgcaaagat tatgattaaa cagtatttaa tgcattgctt
     8401 cataccacaa ttctctcttt caagggcgca aagatataat aagtattgtt caatttgcta
     8461 tccccgcata acaaaaaatg attattttta cactttttat cctaaatcaa ttccgtttcc
     8521 agaaatccgg tgtgaaaagc agcagtacgg taaataactc aagacgaccc agaagcatta
     8581 aaaaggataa cagccattta gctgcatcgg gcagggcatt ccacgaatag gcaggtccgg
     8641 tttcacccaa tccgggtccc atattaccga tactggaaat gacgcagccc attgattctt
     8701 cagccccgac acccatagcc atcatgagca gtgtgccgat gactataatg gcgatataaa
     8761 taaaacaaaa agccagtacg gtggagacaa tggagggaga gattacctgc ttgtttatcc
     8821 gtaccggaag tatggcattg gggtgtagga tgtgtttgaa ctcgtttcgt gagactttgg
     8881 taagaattac catacgtata cacttcaagc ctccggtggt actgcctgca cacgccccca
     8941 tcagcatgat gatggtaagc agcccccaca ggacgggtgt ccattgcatg tagtcatctg
     9001 tcgcaaaacc ggtggatgta tggagggaaa ttacttggaa caaggatttg cggaaggatt
     9061 cttccatccc catgggactg gtatagtaaa gcacgatggc tatgacggca gtgaagagca
     9121 caactgaacc gaaatagaat ttcagctcgg cattgctgat gaacttcttg aatttccggt
     9181 tgacgaacaa taatagcaag gtgaagttga tgccggagat aaacatgaaa atggagatga
     9241 catattctat ataaggagaa ttgtagtagg aaacgctggc ctgcttggtg gagaagccac
     9301 cggtaccggt agtggcaaat gcatggcaga tactgtcgaa ccagtccata cctccaagca
     9361 tcagcagact gacaagcaga gcggttatgc cggcatagat actccaaatc catttggcgg
     9421 tgataccgat acggggatga accttgtcat gtgtagggcc gcttgcctcg gcggcgaaca
     9481 cctgcaggcc actgactccg aagatgggaa gcactgcaat ggtgaacatg atgattccca
     9541 agccgccaat ccactgtgtc atactgcgcc agaacagtat tccatgagga agtgactcga
     9601 tgtcgtccaa gatggtggca cccgtactgc tgaaaccgga catggtttcg aagaatgcat
     9661 tggcaatgtc gggtatgtat ctgcctatat agaaaggcag cattccgaaa agagagaatg
     9721 ccacccaggc aaagctgacc agtacatatc cgtcacggcg cgtcagttgc cgttcacctc
     9781 ccttgccgag agccgccagc aataagccta cccctgctgt gatgcctcct gctttccaga
     9841 agtcgagcat atcgctttct ctgtagtaga aggacacgcc cgaacagacc agaaacatga
     9901 ctgtttccag caatagcaga ataccgataa tccgtatgat tgtcttgaag ttaatcattt
     9961 accaactact cattctcaat tagttaaagt atttttcgat tttcttaatc atcatgttca
    10021 ggcagaatac cactacatgg tcacccggct gtatcagggt gttacccata accacaacgc
    10081 cttccccctg gcggataagt ccgccgatgg tggctccttt cgggaggccg aggtctttta
    10141 ccggatgttt ggtaatcttc gagccggcct taacggtaaa ttctgctaca tcggcattgg
    10201 caaaggtcag gcatttcacg ttgctgacgt ccgcatccag catcatctgg tagatgtggc
    10261 tggcagcaat catctttttg ttgatgacgg tgccgatgtc aaggctttcg gccatgccta
    10321 tgtagtcgat gttctccact tccgctacgg ttttgctgac tcccatgcgt ttggcggcaa
    10381 ggcaggccag gatattagtc tccgagttgc cggtcaaggc aacgaaggct tccgtatttt
    10441 tcagtccctc ttccacaagc aggtccatat cccgtccgtc gccattgata atcatggtac
    10501 ggtcgtcaag cagctcggtc aggcggttgc agcggttcag gtcgttgtcc acgcttttca
    10561 cctgcatgta gtccgggaca tattgggcgg ttcgtacggc aatccggctt ccacccataa
    10621 tcatcacgtt gcgcacatcg gcataatctt ccttgccggc tattttgcgg atgtagggga
    10681 cgtattttcg tgtggtggta aagtatacga tgtcatgtag cttgatggta tcgtcaccac
    10741 ggggaatcag tgtctcgctt ccccgtttga tggctaccac gtgatagggc agctccggtc
    10801 cacccagttc gtggaggggg atgttcagta tctcggcttt ttcgcgcatc ttggtaccta
    10861 tcagtatcaa ggctcctccg cagaattccc accattggcg tacccagctc atgcggatgg
    10921 aagatacgat ttctttggcg gcaagcattt ccggatagat gagtgaatcg acacccagct
    10981 tctggaaaaa ttccttgttt ttgggcagca ggtattcgta gttgtcaata cgggctacgg
    11041 tcttttgtgc tcccagattg tttgccagca tgcatgcggt catgttccgg ctttcatcgg
    11101 gggtgacggc tatgaacaag tctgcctctc ccactcccac ttctttcaag ccttttatgg
    11161 aggtagggga ggccgtagcc gtcatcaagt caaagttgga gttcagtgtg ctcaacttgt
    11221 cttcgttgtc gtccatcaga atgatgtcct gcttctcgcg ggacagcaat ttggccaagt
    11281 gtgtgcctac tgcgccggca cctgcaataa ttattttcac tttctttatg gaaatgaaga
    11341 atgaggaatg aagaatgaag aatttgccat gcggcgtgct tgcatcgcgt agctgaattc
    11401 ttcattcttc attcctcatt cttaattaat aatgtataaa ttccttcttc gtccatttcg
    11461 caaagatgat acaactcttg tatggtgccg tgttctatga aggcatcggg tacaccgata
    11521 cgcctgatat ggggaatata gtcattgtct gccatgaact ccagtacggc actgcccatt
    11581 cctccttttt tgacaccgtc ttctatagtg acaacatgct ggaagttgag tcctacctcg
    11641 tgcagcagcg cttcgtcgag cggcttgaga aaacgcaggt cgtagtgggc tatggagatt
    11701 cctttgtcct tctccgcacg ctctatggca cgtgcggcta cgttgcctat gggaccgagg
    11761 ctgatgactg ccaggtcttt gccttctttc agtttacgcc ctttgcctac ggggatttct
    11821 tccagcggac atttccaatc cagcaatacg ccgcgtccgc ggggatagcg gatgacgaac
    11881 ggaccttggt ccggtaactg tgccgtgtac atcagacggc gcaattcatg ttcgtccatc
    11941 ggtgaagata tggtcaggtt gggaatcgga cggaaatagg ccaggtcgaa aactccgtgg
    12001 tgtgtcggtc cgtcttctcc taccagtccg gcgcggtcca ggcaaagtac gacggggagg
    12061 cggagcaggg cgatgtcatg gatgacatta tcgtatgccc gctgcatgaa ggaggagtag
    12121 atgttgcaga aaggctgcat tccttcttta gccataccgc ccgagaaagt ggctgcatgc
    12181 ccttcggcaa tacccacatc gaaggcacgg tcgggcatgg tgtccatcag cttgttcatg
    12241 gagcagccgg tgggcatggc gggggttact ccgacgattt tcggattttc ctttgccagt
    12301 tctaccagcg tttccccaaa cacgtcctgg aaaagcggag gcaaattgct ggtatccgcc
    12361 ttgaggcgtt ctccggtttc cggatcgaac ttgcccggtg catgccagat atcgggattc
    12421 ttctcggcag gttcgaatcc ttttcctttc acagtgtgca gatgcagtat tttcggtccc
    12481 tgcatatctt tgatgtcccg caggacacgg gctatgtttt tcacatcgtg tccattgata
    12541 gggccgaagt agcggatgtt catcccttca aagatattct gctgctgggc ggccattgat
    12601 tttaggctgt tggcgaagcg aatcagcgct ttgcggcggt cctcgttcaa aagtcccatt
    12661 ttgaacagca gtctggatgt cttgaagcgc agctggttat agcggttgct ggtagtcaag
    12721 ttgaaaaggt actgcttcat gccgcctaca cttctgtcta tcgacatatc attgtcgttg
    12781 agaatgataa gaaggttgtt aggggtagac gaagcgttgt tcagtccttc gaaagccagg
    12841 ccgccgctca tgcttccatc accgatgacg gcgaccacat ggcggtcttt ctcgcctttt
    12901 tcggcagcgg caacagccat gccaagggcg gcggagattg aatttgacgc atgtccgcag
    12961 gtgaatgtgt cataatcgct ttcctctggt gagggaaaag gacgaactcc cttgaattta
    13021 cggttggtgg agaatgcttc acggcgtccg gtcagtatct tgtgcccgta cgcctgatgg
    13081 cctacatccc agactatgcg gtcgtacgga gtattgaata catagtgcaa ggcaacggtc
    13141 agctctaccg tgcccaggct ggcagcgaaa tgtccggggt tacacgaaac ctcctttata
    13201 atgtcttgcc tcaattcttt acagacttca ggaagctctt ctacgctgag ttggcgtaaa
    13261 tcctcgggaa atgtaatggt gttaagcaag ttatatgttg ttggttctgt tctcatttct
    13321 aatctgaaga ttacaaaatg caaaaatagc aaaagaaaac ggatggcggg aagttttaga
    13381 aggaaaaaaa gcctcttttg ttcacttctg tttttgcttt ctctttgcat acgccacatt
    13441 tctcgttcag cctgcctatg gttaagggaa aagatgcctg atagtaaatc gttcctccat
    13501 ggagaaaata ttgttccatc ctgggggaaa aatcgttcca ccatggtgga acgatttttt
    13561 ctccatatag gaatgatttg gtgttagtag acaaggatat taatccttcc aaagattgac
    13621 ttttattctc gcacgtgacc gtctgtgata agagctgctc tacacttgat gtttgttgaa
    13681 aaatgcaatt ttataaatta tttattgcaa ctttttagaa gctttggttg ttgttgatat
    13741 aatattatgt atattgcgaa gtggaatatg tcctgtttat caatatgtta tacaattctg
    13801 aattgtatgt gatggtattc ttggttgtaa tatgtgtcgg aatggggtgt aatcacgaat
    13861 tgttaaatga ataaacaatg aatgatatga agaaaaagct tgactttaaa gttttggcta
    13921 ttatgggcgt agtggttttt tccgcttgcg gttctgatag cgatctgttc aacccggaaa
    13981 aggcggcagc taagaaagag gcacagtatg catcggcttt tgtgcagagg tatggagaaa
    14041 ttgcagttga tcaggattgg ggatttgggg taacaccgac aacgcgtgtt gctaacacta
    14101 atagcaatca atggaaagat tttacggaag taccggggag tgttacggct acagaaaaag
    14161 aagtggttac ggaatggttt aaaacatatc ggaatccaca atccattggg ggggattgga
    14221 ccgacttttt tgttcaacat gtaagtggct cacactctaa tatggatttt ttggttgcgg
    14281 catcagatga ccatatcaat aattttaatg ctactgaggg ggctataatg ctaatgcaga
    14341 atagtgg
//
