LOCUS       c00032_gnlPro..        14938 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LNNOMEEI_32.
ACCESSION   c00032_gnlPro..
VERSION     c00032_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 13:25:07
            Original ID  :: gnl|Prokka|LNNOMEEI_32
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 36657
            Orig. end    :: 51595
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14938
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[46657:51517]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14860
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14938
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14938
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="2"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(41..1021)
                     /locus_tag="ctg32_29"
                     /transl_table=11
                     /translation="MDKIYYKELIEKYFDGNITDAEIKELSDWIKNDRHLQNWWEEEFS
                     KSDAGINPVLRDKLFARIKEQTQGKEETQGKEKPRTIRMNLWKWAAAIVLPICIAFFTY
                     YLIDSSQTVGAPFIVKADKGDKATIELPDGTNVVLNSASQLSYLNNFGENVRRVQLNGE
                     AYFKVAHDEKHAFIVQVGDLEVKVLGTSFNVSAYEDAKDVTVVLLEGKVGVYAQKMSHI
                     MKPGDKIEYNKATHKITATQVHPSDYIEWTKGNIYFEKESLENIMKTLSRIYDVEIRFD
                     SNKLPNEYFTGTIPGGGIQNALNILMLTSPFYYEMDGSVIVLKEK"
     CDS             complement(1089..1685)
                     /locus_tag="ctg32_30"
                     /transl_table=11
                     /translation="MVSFTDEKHLLIDLKGGSFQAFERLYNMYSGKLYNFIMRLSSGNQ
                     YMAEEVVQSTFIRIWEVREKVDTNASFISFLCTIAKNLLMNMYQRQTVEYVYNEYLLKS
                     SVDRDSQTEENIDLHFLNDYIDSLAEELPAQRKKIFILSKRQNYTNKEIAEMMGISEST
                     VATQLSLAVKFMREQLMKHYDKVIALLIAFFVNEM"
     CDS             complement(1898..3196)
                     /locus_tag="ctg32_31"
                     /transl_table=11
                     /translation="MEEKELWMNKLKEKLADYSEPVPASGWEQLEKELMPPVEKKIYPY
                     RKWMMAAAAVILLAVVSSVSLYFLGTPAADEIRHIKTPALASTPDALPGVQQPDVQGTS
                     VEPVLRPVAREDRLAKIDKNLTEQKTNAGQSAIENNNEPVTGNENNPVIEEDQMLKGET
                     EQTKNEARQVDSENVGQATQSQDTERPNNRPRRPSGRDKLHIPAEKRASQKGTWSMGLS
                     VGNSGGASTEVGAGSHAYMSRVSMLSVSNGLMEIPNDQTLVFEDGVPYLRQAKQVVDIK
                     HHQPISFGLSVRKGLAKGFSLETGLTYTLLSSDAKLAGEDQQIEQKLHYVGIPLRANWN
                     FLDKKLITLYVSGGGMVEKCVYGKLGSEKETVKPLQFSVSGAVGAQVNATKRLGIYVEP
                     GVAYYFDDGSDIQTIRKENPFNFNIQAGIRLTY"
     CDS             complement(3203..3751)
                     /locus_tag="ctg32_32"
                     /transl_table=11
                     /translation="MEELELSEQCRLGNNQARKELYEQYAGRMLGICLRYTGDRDTAQD
                     LLHDGFLKIFDSFDKFTWRGEGSLRAWMERVMVNTALQYLRKNDVINQSAPLEELPEEY
                     EEPDASDVEAIPQKVLMQFIEELPAGYRTVFNLYTFEDKSHKEIAQELGINEKSSASQL
                     FRAKSVLAKRVKEWIMHNG"
     CDS             3928..4650
                     /locus_tag="ctg32_33"
                     /transl_table=11
                     /translation="MKKFKFIAFIFAIMTTMPILQSCLDDDDNPSDLLVVSTINMISQD
                     SKEFYFTLDDGKKMYPSNAQGWSNKDWVEGQRAFVIFNELEEPVNGYDLNIQVRGINPI
                     LTKDIITMGEDDNDEEKVGDDKINTTYMWINKDNKYLTIEFQYYGTHSEDKKHFLNLVI
                     NDKEESAPTADEDSAEDEYINLEFRHNSEGDYPQSLGEGYVSFKLDKIKNRMEGKKGLR
                     IRVNTLYGGPKTYEVKFP"
     CDS             complement(4790..5479)
                     /locus_tag="ctg32_34"
                     /transl_table=11
                     /translation="MKKYIAEMIGTMVLVLMGCGSAVFAGSVTGTVGAGVGTVGVALAF
                     GLSVVAMAYAIGGISGCHINPAITLGVFLTGRMNGKDAGMYMIFQVIGAIIGSAILFAL
                     VSTGAHDGPTATGSNGFGDGEMLQAFIAEAVFTFIFVLVVLGSTDSKKGAGNLAGLAIG
                     LTLVLVHIVCIPITGTSVNPARSIAPALFQGGEALSQLWLFIIAPFVGAALSAVVWNYL
                     GDKEEKK"
     CDS             complement(5793..6719)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     61.1; E-value: 2.4e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg32_35"
                     /sec_met_domain="LysR_substrate (E-value: 7.5e-44,
                     bitscore: 141.0, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 1.6e-19, bitscore: 61.1,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIQQLEYILAVDQFRHFARAAEYCRVTQPTLSAMIQKLEDELGV
                     KLFDRTVQPVCPTPIGQKVIDQARVILAQAAQVKEIISEDKQSLSGVFRLGVLPTIAPY
                     LLPRFFPQLMEKYPELDIRVTEMKTQDIQQALHAGDLDAGIIASKLEDTFLTEETLFYE
                     QFYAYVSRKEPSFKHDVIRTSDITGEHLWLLDEGHCFRDQLVRFCQMEAVKVSQMAYRL
                     GSMETFMRMVESGKGITFIPELAVAQLTEEQRQLVRPFAIPRPTRQVVLATNRDFIRHS
                     LLCVLKEEIKAAVPKEMLTLQSIQCLL"
     CDS             6858..7334
                     /locus_tag="ctg32_36"
                     /transl_table=11
                     /translation="MKTLEFIKLNESGANNVVASLQQLLADFQVYYTNLRGFHWNIKGH
                     DFFVLHSQFEKMYDDTAEKVDEIAERILMLGGTPANKFSDYLKVANISEVDKVSNGEQA
                     LNNILQSISYLIGEERKILSIASQAGDEVTVSMMSDYLKEQEKLVWMLTAYNSK"
     CDS             complement(7645..8781)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 57.1; E-value: 4e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_37"
                     /sec_met_domain="AMP-binding (E-value: 2.7e-18, bitscore:
                     57.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFDRKQQRLLLEGKEYTFEDISRLIAGGAEAHSPASWDLYLFLN
                     EWFNDSPVIIVHTSGSTGTPKELIVRKDQMMQSARLTCEFLDLKKGETALLCMNLRYIG
                     AMMVVVRSLVAGLNLIVRPASGHPLADIKEPLRFVAMVPLQVYNTLQVPEEKERLKQTD
                     ILIIGGGAIDEALEAEIKHLPTAVYSTYGMTETLSHIALRRLNGTLASEHYYPFSSVKL
                     SLSVENTLIIDAPLVCDEILQTNDIARIYPDGSFMILGRKDNVINSGGIKIQAEEMEKL
                     LRSFIPVPFVITSVPDQRLGQAVTLLLEGQPELLEGQPDTKEIGNKLQEILEPYYRPKY
                     IWTTDCIPQTENGKVNRAKCRILAKQMLTTFYTHTLTP"
     CDS             complement(8803..9828)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_38"
                     /sec_met_domain="MR_MLE_C (E-value: 7e-28, bitscore: 89.1,
                     seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNCKIEIIPRLLHFKQPAGTSRGTYTTRKVWYLHFTSPDFPGRVG
                     IGECAPLPALSCDDLPDYEDILVKVCRKVEREQGRLDMDGLCDYPSILFGLETAIRHFF
                     AGNWALCDTAFSRGEVGIPINGLIWMGDFQNMLSQIEKKMEAGFRCIKLKIGAINFEEE
                     LTLLRHIRTHFSSKEIELRVDANGAFSPVDAMEKLKRLSEFDLHSIEQPICAGQWEEMA
                     RLAAESPLAIALDEELIGCNTLERKQELLSTIRPQYIVIKPSLHGGICGGDEWITEAEK
                     QQIGWWITSALESNIGLNAIAQWCATFSNPLPQGLGTGALFTDNVEVPLEIRKDCLWFC
                     K"
     CDS             complement(10001..10825)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_39"
                     /sec_met_domain="ECH_1 (E-value: 3.8e-82, bitscore: 266.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYDDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKQYPKFP"
     CDS             complement(10829..12496)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_40"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.7e-07, bitscore:
                     21.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTDKKNILQLVALLEAHGITKVVLCPGSRNTPIVHTLSNHPNFT
                     CYPVTDERSAGYFAIGLALNGGKPAAVCCTSGTALLNLHPAVAEAFYQNVPLVIISADR
                     PAAWIGQMDGQTVPQPGVFQTLVKKSVNLPEIHTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINVPISEPLFQFTVDSLPEVRVITRYQGLNVYDRDYNDLVDRMNKYQKRMIIIGQMN
                     LIYLFEKRYIKLLYKHFAWLTEHIGNQTVPGIPVKNFDAALYAMPEEKVGQMVPELLIT
                     YGGHVVSKRLKKFLRQHPPKEHWHVSPDGEVVDLYGSLTTVIEMDPFEFLEKIASLLDN
                     RTPEYPRVWENYCKIIPEPEFAYSEMSAIGTLLKALPESCALHLANSSVVRYAQLYSIP
                     STIEVCCNRGTNGIEGSLSTAVGYAAASDKLNFIAIGDLSFFYDMNALWNVNVRSNLRV
                     LLLNNGGGEIFHTLPGLDMSGTSHKFIAAVHKTSAKGWAEERGFLYLQAQNDEELAEAM
                     KTFTQPEAMEQPVLLEVFTNKNKDARMLKNYYHQLKQK"
     CDS             complement(12516..13631)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_41"
                     /sec_met_domain="Chorismate_bind (E-value: 3.9e-57,
                     bitscore: 185.2, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEEISNLTTIDAFIQRKQPFAVYRIPGEKVPRLLTQAEGAVRL
                     IYDLKELNGQRGFVIAPFQVSESCPVVLIQPDQWGQPLPVDDDTEEDREIALRLQGQES
                     FLASSTEEYAACFHTFINALRDRTFDKLVLSRHLTVDKVADFSPLSIFRAACKRYIHLY
                     IYLCYTPQTGIWLGSTPEIILSGEKDEWHTVALAGTQPLQDGRLPQVWDEKNRKEQDYV
                     ASYIRRQLLSLDIHSTENGPYPAYAGALSHLKTDFRFSLKDNKGLGDLLKVLHPTPAVC
                     GLPKEEAYQFILQNEGYDRRYYSGFIGWLDPEGRTDIYVNLRCMHIEDKQLTLYAGGGL
                     LASSELNDEWLETEKKLQTIKRLIAVPPLKS"
     CDS             complement(13628..14860)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_42"
                     /sec_met_domain="HBT (E-value: 6.4e-18, bitscore: 56.5,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKMLELGNYGGFILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNG
                     FALFTYHDDTIITDSPENEHIQNEARLNNLQIIKEEEFSAAVDFAPCKCMLVSDDEEAL
                     VGLEDHWKRRLNGALDVFRSEPYFLEVVPCAIDKANSLGALLEVLDVKREEVIAVGDGV
                     CDVTMIQLAGLGVAMGHSQDSVKACADYVTASNEEDGVAVAVEKAIIAEVRAAEIPLDQ
                     LNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALAETVAGLGS
                     MILCQPDEIVVGMQVSGNHISSAHEGDTVRAVGTVVHKGRSSHVWNVDVFTSTNKLVSS
                     IRVVNSVMKKR"
ORIGIN
        1 tattcaatga ataaacaaag atactctatg aaagttccac ttatttctct ttcaaaacaa
       61 tcaccgaacc gtccatttca taatagaaag gtgaagtaag catcaggata ttcaatgcat
      121 tctgtatgcc acctcccgga atggttccgg tgaaatattc attaggtagt ttattggagt
      181 cgaaacgaat ctctacgtca tagatgcgtg aaagggtttt cattatattt tccaaagatt
      241 ctttctcaaa atagatattt cctttcgtcc attcaatgta gtcactcggg tgtacttgag
      301 tggctgttat cttatgagtg gctttattat attctatttt gtcgccgggc ttcatgatat
      361 gcgacatttt ctgcgcataa acccctactt ttccttccaa aagaacgacc gtcacgtctt
      421 tggcatcttc ataggcagat acattaaaag aagtaccgag tactttcact tccaaatccc
      481 cgacctgcac tataaaggca tgtttttcat catgagctac tttgaaatag gcttcaccat
      541 tcagttgcac acgacgcaca ttttctccga agttattcag atagcttaat tgtgaagctg
      601 aattgagaac gacattcgtt ccgtccggca attcgatggt tgctttatct cctttatcgg
      661 cttttactat aaagggcgct cccactgttt gcgaagaatc tataagatag taggtgaaga
      721 aggcaataca aatgggtaaa acgatggcgg cagcccattt ccaaagattc atgcgaatag
      781 ttcttggttt ctcttttccc tgtgtctctt cttttccctg cgtctgttct ttgattcggg
      841 caaatagttt gtcgcgcagt accggattaa taccggcatc cgatttggaa aattcttctt
      901 cccaccagtt ctgtaaatgg cggtcgttct ttatccaatc ggaaagttct ttaatctccg
      961 catccgttat atttccatcg aaatactttt caatcagttc tttataatat atcttatcca
     1021 tcttctttcc tgcttattta caagtataca ttttcatcct atctactatc caaaaacgtg
     1081 tattacaatt acatttcatt aacaaaaaag gcgatcagaa gcgcaattac cttatcgtaa
     1141 tgcttcatca actgctcacg cataaatttc accgccaaag ataattgtgt ggcgactgta
     1201 ctttcagaaa tacccatcat ttcagcaatt tccttattcg tatagttctg acgcttactt
     1261 aagataaaga ttttctttcg ctgtgccggc aattcttccg ctaatgagtc gatatagtcg
     1321 ttcaagaaat gaagatcaat attctcttct gtttgcgaat cacgatccac actgcttttc
     1381 agcagatatt cattgtaaac atattcaacg gtctgacgct ggtacatgtt catcagtaaa
     1441 tttttggcta tcgtacaaag aaaagaaata aatgaagcgt tggtatcgac tttctcacgt
     1501 acttcccata tacggataaa agtggattgc accacttctt cagccatata ttgattgccg
     1561 gaagaaagcc gcataatgaa attgtacagt ttaccgctgt acatattata caatctttca
     1621 aatgcttgaa aagaaccgcc ttttaaatcg attaataaat gtttttcatc tgtaaaactc
     1681 accatagctt agaattttgc aacaaaggta tgcaaccata gaccattaac aggtgacaat
     1741 attattaata ttttctcaat tatccgattt ttatgaagaa aaagatacta atatcaggat
     1801 agtgacgcca tccggtcaag atagtgacgc tatctaatca ggatagtgac gctatcttga
     1861 acggataccg tcactatgtt cagtatggta attcgcatta ataagtcaaa cggataccag
     1921 cctgtatatt gaagttaaac ggattctctt tacgtatggt ctgtatatcc gaaccatcat
     1981 caaaataata agcaacaccg ggttctacat agatacccag acgtttcgtt gcgttcacct
     2041 gtgcacctac cgcaccggat accgagaatt gcagaggttt caccgtttct ttctcggaac
     2101 cgagctttcc atagacacat ttctccacca tacctccacc ggaaacgtaa agagtgatga
     2161 gttttttatc aaggaaattc cagttggcac gcagcggaat acctacataa tgaagttttt
     2221 gttctatctg ctgatcttca cccgccagtt tcgcatccga agaaagcaat gtgtaagtca
     2281 atcccgtttc gagagagaat cctttggcca gtcctttacg gacagacaat ccgaaagaaa
     2341 taggttgatg gtgcttaatg tcgaccactt gttttgcctg acgcaaataa ggcactccat
     2401 cttcaaaaac caatgtctga tcgttaggta tctccatcag accgttggaa acagaaagca
     2461 tactcacacg agacatataa gcatgagagc cggcaccgac ttctgtggat gctccgcccg
     2521 aatttccgac cgagagtccc atggaccatg ttcctttttg agatgctctt ttttctgccg
     2581 gaatatgcag cttgtctctg ccggaagggc gacgcggcct gttgttcggc cgttcggtgt
     2641 cctgtgactg tgtagcctga cccacatttt cactgtcaac ctgccttgct tcatttttcg
     2701 tctgttccgt ctcacctttg agcatctggt cttcctcaat cacaggatta ttttcattcc
     2761 ctgttacagg ttcgttgtta ttttctattg cagattggcc tgcatttgtt ttctgttctg
     2821 taagattctt atcaattttc gccaaacggt cttcacgagc cactggtcgc aagacgggtt
     2881 ctacggaagt gccctgcaca tccggttgtt gcacacccgg caacgcatcg ggtgtagatg
     2941 ccaatgccgg agtctttata tgacgtattt catccgcggc cggtgtcccc agaaaatata
     3001 gacttaccga cgaaacgacg gctaacaata taacagctgc agcagccatc atccattttc
     3061 gataaggata tattttcttc tccacaggag gcataagttc tttttccagt tgttcccaac
     3121 cggaagcagg caccggctcg gaataatccg cgagcttctc cttcaactta ttcatccaca
     3181 attctttctc ttccatctct atctatccat tatgcattat ccattctttt actctttttg
     3241 ccaatacact cttcgcacga aatagttgcg aagccgaaga tttttcatta atacctaatt
     3301 cctgtgcgat ttctttatgc gatttgtctt cgaatgtata aaggttaaac actgtacgat
     3361 atccggcagg tagttcttct ataaactgca tcaacacttt ctgtggaata gcttctacat
     3421 cagaagcatc cggttcttca tattcttcag gcaactcttc taatggtgcc gactgattga
     3481 ttacatcatt tttccggaga tattgcaaag ctgtgttgac catcaccctt tccatccagg
     3541 cccgcaggga gccttcaccc ctccaggtga acttgtcgaa ggaatcgaat atctttaaaa
     3601 aaccgtcgtg aagcagatcc tgggctgtat cacggtcgcc ggtataacga agacagatgc
     3661 caagcatacg tcccgcatac tgctcataca gttctttgcg agcttggtta ttgcctagcc
     3721 tgcattgttc cgacaactct aattcttcca ttctcttata cacgtgttta acttataaat
     3781 gcagcaaaga tagaaatact gcatagagag aacaactctt ttatcacttt tgtttcttta
     3841 acagattcaa atgcaatatt ttctatccca ttgcattttc acaatacaaa ggaaccattt
     3901 tatataatct aaaacttaaa taagtatatg aagaaattta aattcattgc ctttatcttt
     3961 gctattatga ctacaatgcc gattctccag tcatgtttgg acgacgatga caacccgtcc
     4021 gatcttctgg ttgtcagtac catcaatatg attagccagg atagcaagga attttatttc
     4081 actttggatg acgggaaaaa aatgtatccc agcaatgcgc aaggatggag taataaagat
     4141 tgggtggaag gacaacgagc ttttgtgata ttcaacgagc tggaagagcc tgtgaatgga
     4201 tacgacctta atattcaggt gagaggtatc aatccaatct taactaaaga catcatcacg
     4261 atgggtgaag atgacaacga cgaagaaaaa gtcggagatg acaagatcaa cacaacttat
     4321 atgtggatca acaaggataa taaatatcta acgattgaat tccaatatta tggaacgcat
     4381 agtgaagata aaaaacattt cctgaatctc gtaatcaacg acaaagaaga gtctgctccc
     4441 actgctgacg aagacagtgc ggaggacgaa tatatcaatc tggaattccg tcataacagt
     4501 gaaggtgatt atcctcaaag cctgggcgaa ggatatgtat ctttcaaact ggataagatt
     4561 aaaaaccgga tggaagggaa aaaaggatta aggatccgtg tcaacacttt atatggcgga
     4621 ccgaaaactt atgaagtaaa gtttccctaa gattataaat ctaatgtaaa cgtgcaaaac
     4681 acactctttt ttaatataat atattaatta cgcaaaagag ggcggtagtt gtgaaactgc
     4741 cgccctttta tcttctcctt tatataaaga agttatcctt ataaaggaat tatttctttt
     4801 cttccttatc tcccagataa ttccaaacta ccgcactcaa cgcagctcct acaaatggag
     4861 caatgatgaa cagccacaac tgcgacaatg cttctcctcc ctggaataat gccggagcaa
     4921 tactacgcgc cgggtttaca gaagtccctg tgataggaat acatacaata tgtaccaata
     4981 caagagtcaa accgatggca agtcctgcca gattgcctgc tcccttcttc gagtcggtag
     5041 agccgagcac cactaataca aaaataaaag taaatactgc ttccgcaatg aatgcctgca
     5101 acatttctcc atcgccaaaa ccattggaac ctgtagccgt aggtccgtca tgagcaccgg
     5161 tggaaactaa agcaaaaaga atagccgagc cgataatagc tccgattacc tggaaaatca
     5221 tatacatacc tgcatctttt ccattcatac gcccagttaa gaacactcct aatgtaatag
     5281 caggattaat gtgacatcct gaaatacctc cgatagcata cgccatcgct actactgaaa
     5341 gaccaaatgc taaagctacg ccgactgttc ccacgccagc acctaccgta ccggttacac
     5401 taccggcaaa gacggcactt ccgcatccca taagaacgag caccatcgtt ccaatcattt
     5461 ctgcaatgta ctttttcata actataaata atggttaatg catcaaatat agagaattaa
     5521 cccaagaaaa caaaacctac gtgcctaaat tattattgcc ttcgcaacat ttttgaataa
     5581 aagacaagca aataaaatga aaaaaggact tttgcacacc atattagcct ctaccttatg
     5641 ggcacatcgt aaactctttt atcaagcaag gattgagcaa tgacgccact ccgatgaatt
     5701 tctccgaaac ccgctttgcc actgttggaa ttattctttt cgcttatacc cggtacgagg
     5761 gtatatgaca ggaatcatct caatctctat tattatagca aacattgtat ggactgcaaa
     5821 gtaagcattt ctttggggac tgcagctttt atttcctctt tcagaacaca tagcaggctg
     5881 tgacgaataa aatctctatt tgtcgccagc accacttgcc gcgtcggtcg ggggatagca
     5941 aacggacgta ctaattgtcg ctgttcttcc gtcaattgag ccactgccag ttcgggaata
     6001 aaagtgattc cttttccgct ttctaccatt ctcataaagg tttccatgct tcccaggcga
     6061 taagccatct gactaacctt caccgcttcc atctgacaga aacggacaag ttggtcacga
     6121 aaacaatgtc cttcgtccaa aagccaaaga tgttcgccgg ttatatcgga agtgcggata
     6181 acgtcatgtt tgaacgaagg ttctttccgt gatacataag catagaattg ctcatagaag
     6241 agagtttctt ccgtcaagaa tgtgtcttct aatttactgg caataatccc tgcatccaaa
     6301 tcgccggcat gcaaagcttg ctgaatatcc tgggttttca tctccgtgac acgaatatcc
     6361 agttcgggat atttctccat cagttgaggg aaaaagcggg gtagcaaata aggagcgata
     6421 gtgggtaata ctcccaaacg gaatacacct gataatgatt gcttatcttc actgatgatt
     6481 tcttttactt gagctgcctg cgccagaatc acacgagcct ggtctatcac tttctgcccg
     6541 atgggtgtcg ggcagacggg ttgcactgtc ctatcgaata actttactcc caattcatct
     6601 tccagcttct gaatcatggc actcaaagta ggttgcgtca cacggcaata ttcggctgcc
     6661 cgtgcgaaat gcctgaactg gtctacggct agtatatatt ctaattgttg tatcgtcatc
     6721 tatcaaatca tattaagtta tagatttcat ctatgcaaag atagaaattt tcagtttgac
     6781 aacaagcatt ttccgcctta tctttgcagt acagaaaaaa aagaaaacaa gtataaatca
     6841 ttaaaaataa aaagaatatg aaaactttag aatttatcaa actgaatgaa tcgggagcaa
     6901 acaacgtagt agcatctttg caacaactat tagcagactt ccaagtgtat tacaccaatc
     6961 tccgcggttt ccactggaat atcaaaggac atgatttctt tgttctccac agccaattcg
     7021 aaaagatgta tgatgacaca gccgaaaagg tagacgaaat tgcagaacgt atcttgatgt
     7081 tgggcggtac tcctgccaat aaattcagcg attatttgaa agtagcaaat atcagtgaag
     7141 tagataaggt gagcaacggc gaacaggcac tgaacaatat ccttcagagt atcagttatc
     7201 tgattggtga agaacgtaaa atcttgtcta tcgcttctca agccggagat gaagtaaccg
     7261 tttcgatgat gagcgattat ctgaaagaac aggaaaaact agtttggatg ttgacggctt
     7321 ataatagcaa ataattaaga taaaaggttt aggtttttaa gtgagaaaga gaggatattt
     7381 ccgtaaaagg aatattctct ctttattatt tccagtgtac tagtactatc taaatacgtt
     7441 cattcgctga tattattaaa aaaattagtt ttgttcttta tttatcaaga tttataaaag
     7501 taagcaacaa ctttcaaaag atgaaactta ttctactgaa ataaaatgtc ttaccctgaa
     7561 ttttgttgac tctaataagt ctcaactaaa actagggtaa gacaattaga ggcccctgaa
     7621 acgttgatga ataaaggatt tcaatcaagg tgtgagagtg tgagtgtaaa acgtcgtcaa
     7681 catttgtttg gctaaaatac gacacttcgc acgattaacc ttgccgtttt ctgtttgcgg
     7741 aatacaatct gtcgtccata tgtacttggg acgataataa ggttccaata tttcctgtag
     7801 tttgtttccg atttctttag tgtccggctg accttccaat aattctggct gaccttccaa
     7861 tagtaaggtt acagcctgcc ctaaacgctg gtccggaact gaagtaataa caaatggcac
     7921 aggaataaaa gaacgaagca atttctccat ttcctccgcc tgaatcttaa ttcctccact
     7981 atttatcaca ttgtctttcc gacccaaaat cataaaactt ccatcgggat agatgcgtgc
     8041 aatgtcattg gtttgcaata tttcatcaca taccaaaggg gcatcaataa ttaacgtatt
     8101 ctctacagat aaagacagtt ttactgaaga aaacggataa taatgttccg aagccaatgt
     8161 tccgttcagc cgacgaagag caatatgaga taaagtttca gtcatgccat aggtagaata
     8221 gacggcagtc ggaagatgtt tgatctccgc ctctaaagcc tcatcaatag ctccaccacc
     8281 tataatcaaa atatccgtct gtttcaatcg ttctttctct tcgggaactt gcaacgtatt
     8341 ataaacttgc aggggaacca ttgccacaaa tctcaaaggc tcttttatat ccgctaaagg
     8401 atgaccggaa gcaggacgta caatcaaatt caagcctgca accaacgaac gcacgaccac
     8461 catcattgca ccaatataac gaagattcat acaaagtaat gccgtctctc ctttcttcaa
     8521 atccagaaac tcacaagtca gacgcgcact ttgcatcatc tggtctttac gtacaatcaa
     8581 ctctttaggt gtacccgtag agcctgatgt atgaacaatg atgacaggag aatcgttaaa
     8641 ccattcgttc aggaaaagat ataaatccca actagcagga gaatgagcct ccgctcctcc
     8701 tgctattaat cggcttatat cctcaaaagt atattctttt ccttccagta acaagcgttg
     8761 ttgttttcga tcgaatatca tcggaatatc ctttaaatac tatcatttac aaaaccataa
     8821 acaatctttt cttatttcaa gaggcacttc cacgttgtct gtaaagagcg cccctgttcc
     8881 cagtccctgt ggcaacggat tgctgaatgt tgcacaccac tgggcaatgg cgttcagacc
     8941 aatgtttgat tccagagcgg aagttatcca ccagccgatc tgttgttttt cagcttcggt
     9001 aatccattcg tctcctccgc atattcctcc atgaagagaa ggtttaataa cgatatattg
     9061 cggacgaatt gttgaaagca gctcctgttt cctttccagc gtattgcatc ctatcagttc
     9121 ttcatccaaa gcaatcgcta atggagattc ggcagcaagc cgagccattt cctcccattg
     9181 tccggcacag attggctgtt cgatagaatg taaatcaaac tcggacagac gtttcagttt
     9241 ttccattgcg tccacgggtg agaaagcacc atttgcatct acacgcaact ctatttcttt
     9301 agaagagaaa tgcgtacgaa tatggcgcaa caatgtcagt tcttcttcga aattgatggc
     9361 acctatcttt aacttgatac aacgaaatcc ggcttccatc tttttctcaa tctgggataa
     9421 catgttctga aaatctccca tccaaataag gccgttaatc ggaataccaa cttctccacg
     9481 tgagaaagcc gtatcacata aagcccagtt tcctgcaaag aaatgccgga tggccgtttc
     9541 cagaccaaat aaaattgaag gatagtcaca caagccatcc atatccaatc tgccttgttc
     9601 cctctctact ttccggcaga ctttcactaa tatatcttcg taatcaggaa gatcgtcaca
     9661 acttaaagcg ggcaaaggtg cacactcccc tattcccact ctgccaggga agtcaggaga
     9721 ggtaaaatga agataccaaa ctttacgcgt agtatatgtt cctctggaag tcccggcagg
     9781 ttgcttgaaa tggagcaatc ggggaataat ttctatttta caattcatcg tgaataattt
     9841 ttcaattcac cacagaataa cacagagcct cacgaagttt taataagtta tatctcttgc
     9901 agttctccta ccattctctc ctccacagtc ttgctttgca gaaaatcggg cttaaacgca
     9961 ggaaaagcaa actctgtggt actctgtggc aaagccgatt ttaagggaat ttcggatatt
    10021 gtttgaagtt cggtttacgt ttctccagaa acgcattctt tccttcctgt gcttcatcag
    10081 tcaggtaata gagcaacgtt gcgtcacctg ccagttcctg aatacctgcc tgaccatcca
    10141 gttcggcatt caatcctgct ttaatcatgc gcaaagccaa cggactaagc aacatcattt
    10201 cttccgccca ctgtacatat tcgtcctcca actgctccaa aggaactact ttattcacta
    10261 atcccatgtc caatgcttct tgtgcattat acttccggca gaggaaccag atttcgcgcg
    10321 ctttcttctg ccccactaca cgtgccagat aagacgcacc gaatccggca tcaaagctac
    10381 ctacacgagg acccgtctga ccgaaaatag cattttccga cgcaatggac aaatcacata
    10441 ctacatgaag cacatgtccg ccaccaatag caaaaccgtt cacggcagca atcaccggtt
    10501 tcgggatgct gcgaatctgc ttttgcacat ccaatacgct aagacgaggc acaccgtctt
    10561 ttccgatata tccgccacgt cctttcacat tctggtcgcc gcccgaacaa aatgccttat
    10621 caccggctcc ggtaatcaca atcacatcaa tatccgcttc ttcacggcag atgcgcaatg
    10681 cgtcactcat ttcagcagta gttgtcggag taaacgcatt ccgatagcgc tcacggttga
    10741 tcgtgatacg ggcaattcca ttataataat caaaaagaat atcgtcgtat tctctgatgg
    10801 ttgtccactc tctttgtgtt gacataatct atttttgttt taattgatga taataattct
    10861 tcaacatgcg cgcgtcctta tttttgttgg taaacacctc caagagcaca ggctgttcca
    10921 tagcttccgg ttgagtgaaa gttttcatcg cttcagccag ttcttcgtca ttttgtgctt
    10981 gcagatagag gaatccacgt tcctccgccc aacctttggc cgacgtttta tggactgccg
    11041 caataaattt atgtgaggta cccgacatat ccaatcccgg caaggtatgg aaaatctctc
    11101 ctcctccatt atttaacaga agaacacgca gattggagcg aacattgacg ttccacaacg
    11161 cattcatatc atagaagaag ctcaaatctc cgatagctat aaagttcagt ttgtcggaag
    11221 ctgccgcata accgacagcc gtagacagcg agccttcaat accgtttgtc ccccggttgc
    11281 aacaaacttc aatcgtagaa ggaatggagt ataattgcgc ataacgcacc accgaactgt
    11341 ttgccagatg caacgcacat gactccggca aggctttcaa taacgtaccg atggcagaca
    11401 tttccgaata agcaaactcc ggttcgggaa tgatcttgca atagttttcc cacacacggg
    11461 gatattcagg agtccgattg tccaacaaac tggctatctt ctccagaaac tcgaacgggt
    11521 ccatttcgat caccgtagtt aatgagccgt acaaatcgac cacctcacca tccggcgata
    11581 cgtgccaatg ttctttaggc ggatgctgac ggagaaactt cttcagccgt ttggaaacga
    11641 catgtcctcc ataagtaatc aacaactccg gaaccatctg gccgaccttc tcttcgggca
    11701 tggcataaag cgccgcatca aagttcttta ccggaatacc gggaactgtc tggttgccga
    11761 tatgttcagt caaccaggca aaatgtttat ataataactt gatatatctt ttttcaaaca
    11821 gatagataag attcatctga ccgatgataa tcatacgctt ctggtattta ttcatccgat
    11881 cgaccaaatc gttataatca cgatcgtaga cgttcaaccc ctgataacgg gtaatgacac
    11941 gcacttcagg aagcgaatcg actgtaaact ggaacaacgg ttcagaaata ggaacattga
    12001 tatgtaccgg tccttttcca tgatggttcg tttccagcaa agcttcattc accagacgat
    12061 tgcaatacca ttcatcttct tccgtatgaa tctccggaag gtttaccgac ttcttaacca
    12121 atgtctgaaa tacgcctggt tgtggtactg tctgtccatc catctgcccg atccaggcag
    12181 cgggacgatc cgcagaaata atgaccagag gaacattttg ataaaatgct tctgccacag
    12241 ccggatgaag gtttaataat gcagtaccgg aagtgcagca gacagctgcg ggcttaccac
    12301 cattcaacgc aagaccaata gcaaaatagc cggcacttcg ttcatccgtc accggatagc
    12361 aggtaaaatt cggatggtta gacaaagtat gtactatggg cgtattacga ctacccggac
    12421 acaacacaac cttagtaatc ccatgcgcct cgagcaacgc aaccaactgg agtatgttct
    12481 tcttgtctgt atacatgatg ataattatta gtagtttatg attttaaagg aggcactgca
    12541 atcagccgtt tgatggtttg caacttcttc tccgtttcca gccattcgtc attcaattcc
    12601 gaagaggcca ataatccacc gccggcataa agagtaagtt gtttatcttc gatatgcata
    12661 cagcgtaagt ttacatagat gtctgttcgc ccttccggat cgagccatcc gataaagccg
    12721 gagtaatagc ggcggtcgta accttcattc tgcaaaataa actgataggc ttcttctttc
    12781 ggcaagccgc atacggcagg tgtcggatgc aaaactttca gaaggtctcc caaaccttta
    12841 ttatctttca aagaaaaacg gaaatcagtt tttaaatgtg acaaagcacc ggcataagca
    12901 ggatatggcc cgttttccgt agaatgaata tccagtgaaa gaagctgccg acggatataa
    12961 gaagcaacat aatcttgttc tttccggttc ttttcatccc atacttgtgg cagtctgcca
    13021 tcttgcaaag gctgtgttcc ggctagtgca accgtatgcc attcgtcttt ctcacctgat
    13081 aaaatgattt caggagtgct tcccagccag atgcccgtct gcggagtata acataagtaa
    13141 atatacaaat gaatataacg tttacaagcc gcccgaaaga tggacaaagg agaaaaatcc
    13201 gcaactttat caactgtaag atgacgggaa agcactagtt tatcaaacgt cctgtcacgt
    13261 aacgcattta taaaggtatg aaagcatgcc gcatattctt ccgtagaaga agccaaaaat
    13321 gattcttgtc cttgcaggcg caaggctatc tcccggtcct cttccgtatc atcatccacc
    13381 ggtaaaggct gcccccactg atcgggttga atcaacacaa ccggacatga ctcactcacc
    13441 tgaaacggag caattacaaa tcctctctgt ccattcagtt ctttcaaatc gtatatcaaa
    13501 cggaccgctc cttccgcctg cgtcaacaga cggggaacct tctctccggg aatacggtaa
    13561 acagcaaacg gctgcttccg ctgaataaat gcatcaatag ttgtcaagtt acttatttct
    13621 tcgtcggtca tctctttttc atcacactgt tgactacccg tatggaagac accagtttgt
    13681 ttgttgaagt aaacacgtct acattccata cgtgggagga acgtccctta tgtacaactg
    13741 ttcctaccgc acgcactgta tctccttcat gtgcagaaga tatatggttt ccgctgacct
    13801 gcattcctac tacaatctcg tccggctggc aaagaatcat cgaaccgagt ccggcaactg
    13861 tttctgccag tgcaagagta gctcccccat gcaaaatgcc gaaaggctga cgggtacgat
    13921 ggtctaccgg catcgttgct tccacacggt cttcgtcggc gtatgtatat tgaattccca
    13981 agtttcccat taatgcgtgg cgtgcctgcg cattcagttg gtcaagggga atttcggctg
    14041 cacgcacttc agctataata gccttctcca ctgcaacggc cactccgtct tcctcattcg
    14101 aagcggtcac atagtcggca caggctttca ccgagtcttg tgaatgtccc atagctacgc
    14161 ccagcccggc caattgaatc attgttacgt cacacacacc gtcgcccaca gcaatcactt
    14221 cctcacgctt cacatccagt acctccagca aagcacccaa agagttggct ttgtcgatag
    14281 cgcagggaac tacttccaaa aaatatggtt ccgaacggaa tacgtccaac gctccgttca
    14341 gtcgtctctt ccagtgatct tccagaccaa ccagtgcttc ttcgtcatcg ctcaccagca
    14401 tacacttaca aggagcaaaa tcaacggcag cagaaaattc ttcttcttta attatttgca
    14461 ggttattcaa ccgggcttca ttttggatat gttcattttc aggagagtcc gttatgatcg
    14521 tatcatcatg ataagtgaat aaggcaaaac cgtttttacg ggctttcttt tccagatacg
    14581 gcaacatttc gggattaatc cgacgttcaa acagaatttc cccgttttgt gcattgataa
    14641 tctgacagcc attataggaa aggataaaac ctccatagtt tccaagttca agcatcttgg
    14701 ccagcggcat caggccataa gtaggtctgc cggatgccag cacaatacgt actcccattt
    14761 gctgaacctt caacagggca gccaatgtac gcttactaat ttctttcgca tcattgagga
    14821 gtgttccgtc tacatcaaga accaataatt tatacttcat gattacacga ttttgattta
    14881 gattacaaaa ttatatagaa aaatcgagtt tttctacacc ggcacaataa aaaccgag
//
