LOCUS       c00073_gnlPro..        15193 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LNNOMEEI_73.
ACCESSION   c00073_gnlPro..
VERSION     c00073_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 13:25:07
            Original ID  :: gnl|Prokka|LNNOMEEI_73
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 6651
            Orig. end    :: 21844
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15193
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[16651:21208]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14557
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15193
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15193
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(473..1267)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg73_8"
                     /sec_met_domain="F420_oxidored (E-value: 2.4e-14, bitscore:
                     44.2, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPIVFIGAGNLATNLAKALYHKGFRIVQVYSRTMESAR
                     TLAEKVEAEYTTDLQEISKDAKLYIVSLKDAALVDLLPQITEGKQSSLLVHTAGSIPMS
                     IWEGHAERYGVFYPMQTFSKQREVNFQEVPFFVEAKRPEDVEFLKAVAATLSEKVYEAS
                     SEQRKSLHLAAVFICNFTNHMYALAADLLEKYNLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMNNHLAMLVDSPALQEIYKLMSKSIHEHHQL"
     CDS             complement(1613..2149)
                     /locus_tag="ctg73_9"
                     /transl_table=11
                     /translation="MENFSELIKNRRSMRKFTDEELTQDQVVTLMKAALMSPSSKRSNS
                     WQFVVIDDKEVLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWVQVRERFTATGMPSDEFVHGILGIPLQLQILSVIAIGHKGMERKPFNEE
                     HLQWEKIHINKFGGK"
     CDS             2329..2553
                     /locus_tag="ctg73_10"
                     /transl_table=11
                     /translation="MKKRITQDDYIKANRKASREAEIEMYGHPICHKRVHQSKKVYNRR
                     KIKAADKKLPYFFAFKIASLSSRHSDTIQ"
     CDS             complement(2650..3228)
                     /locus_tag="ctg73_11"
                     /transl_table=11
                     /translation="LCNRTELLKSGTMLEEILAYNKQFVENKGYESYITNKYPDKKIAI
                     LSCMDTRLTALLPAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVI
                     AHSDCGACHMHSEEMLEKMKARGINPDYIDMMRFCGVDFHSWLDGFEDTEKSVRGTVDF
                     IVRHPLIPSDVTVYGFIIDSTTGELTRIV"
     CDS             complement(3299..5323)
                     /locus_tag="ctg73_12"
                     /transl_table=11
                     /translation="MKSTIYKIAALTFAVASMSACSLDEYNPSQKTGDEILATFDGLKG
                     LQSYCYSSLYGQLFSVYDFLSVAEGGTDCWITPAGNPDYAKQVIYYDGLATNTNATNKL
                     FGQAYSMIGNCNAVVNRAELLTDGNEKDITTLVAEARCLRAFYYSILVNTYGNVTLTLE
                     ESSQDPILTPQRNSIEELYTQIIDDLKFAANNLEDTPYDNNRARVTKKTALGLLARVYA
                     QGGGEYGLTEEGVSYWQRAKEVAEDMILAYGDCLYDDVEDVWAPANNRNNKEALFIAAG
                     PDATNLENWNAGTQCNNNFTYMYPKPNTLTIYPTPDNQNYWYGRTNNNTLAPSKYLLDC
                     FDADYDKRWEVTFTTAFVQFSAVQSGGSYLFTNKKQTLDDGTKPKIGTKHGVNDNISSF
                     TILTQNIIDTYGLDAKFHNEYIYPYGDLNYTYYDGTWAPKMIAKVWPKGENSGDPSKLQ
                     EVKNPYVIPYPVAEDDDRICFYLSKERLSDAEKAKRRYYVINIDDLFDNGQYRKTDIKV
                     TNDKNMYPGFNKYNWLSEDSYSSNLQRKTGDVFIMRMAEVYLIAAEANQQLGNGGKAAE
                     YLNVLKKRAARNDASYNAMKLSNATQNDVMDEYARELCGEYQRWVLMKRHKDSFKQRLA
                     VGNPRAAENFDENKHYLRPISFNFLSQIDNAEEYGNNGY"
     CDS             complement(5348..8533)
                     /locus_tag="ctg73_13"
                     /transl_table=11
                     /translation="MILGLSLLSAPLSYSVYAEDGVSNTMVQVVTQTKTVKGTIIDESG
                     EPLIGVSIVVKGTSTGTITDFNGNFSIDLPAGRKELVISYIGYKEQTVTVTGNGPVNVK
                     MVSDTQALDEVVVVGYGTMKKRDLTGAITSVKSEDVVMNPSSNPMQALQGKVAGLDITR
                     ESGQAGSGVKMQLRGNRSFQKDSGNPLFIIDGMPGDYSTLNPNDIESIEVLKDASSTAI
                     YGSSGANGVILITTKGGKEGKAIVNFNAYVGVNGWSRTPEMRSGESYIQTLRDASVGAG
                     DGRWSSVADDKNLFTTDAEWSAHQNGQYIDWVDALLKTSVTQNYSVSVAGGTEKTKAYF
                     SLNFSNEDGQFAQDSYKLYSSKIRVDHKIKKWMKVGIDAQLSYVHQNKADSDLQTLMAS
                     NPLGSLYNEDGSINPQPVADPSSTVYNYLLNEDKSLYRNQAQNLKVYFNPYLEITPLKG
                     LTFITRAGASLGYSRSNTFTGEGSVQWYKANQTADGIKAQVKDNRSYNYKWENILTYNF
                     QIKKVHDITLTAVTSWNHNRSDVTTLYQKGVSDNKFLWHNILDGNSATSGSTSYSMSKG
                     MGYVGRLNYSYMGRYLFAASVRHDGSSRLAEGNKWDTFPAFSLGWRISDEKFMESTTNW
                     LSNLKIRFGYGVTGSTAGIDPYSSAASLDATAVNMILGGVLTPIYKFSQNIPNYLLTWE
                     KSYNTNIGIDAAFLNNRIDVSMEYYNTKTKDVIWNKALPVINGAFSPDGGPKANYTTNL
                     NMCETSNKGFELALNTRNIITKNFTWSSSVTFNHNKEKITKLSGGDSDVLNNGDTGYAL
                     ALGEAINSYYHYKLDGVWQKGEETDAAVFGAAPGDLKINIPNLVKESDGRFYKIDEETG
                     SAAVDENGNVIYYTSDNKYTPSDADYQILGHNSPDWSLGFQNNFTWKDFDLSVFVYARY
                     GQMFAYDMLTSYDPKGIRNFPTYFNYWTENNPSNDFPAANANKGLEQYTGYYALRYVDG
                     SFIKIKNITLGYSLPKSILKSAGIEKCRFYATITNPFVFAKSHLLKDYDPEMNGSLKYP
                     LTKQFVFGVNVTF"
     CDS             8827..9825
                     /locus_tag="ctg73_14"
                     /transl_table=11
                     /translation="MPLKLTTYYHGKDIPELPGKNAFHSKELFQIYEATPGYTPLLIVA
                     TEDGRPMARLLAAIRKAKKWLPSSLVKHCVVYSEGEFLDESLSTNKEKAEEVFGDMLEH
                     LTQEASRSCVLIEFRNLNNSMFGYRVFRANDYFPVNWLRVRNSLHSMKKTEDRFSPSRI
                     RQIKKGLKNGAKVEEAHTVEEIHDFSRMLHKVYSSRIRRYFPANDFFRHMNNMLIKGQQ
                     AKIFVVKYKEKIIGGSVCIYSGDDAYLWFSGGMRKTYALQYPGVLAVWKALEDAHQRGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRINWSWLNKLLVKFYV"
     CDS             10001..10405
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_15"
                     /sec_met_domain="Glyoxalase_4 (E-value: 5.3e-24, bitscore:
                     75.1, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAEGKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             10434..11987
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_16"
                     /sec_met_domain="CT_Btheta (E-value: 3.2e-290, bitscore:
                     953.0, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             12019..12939
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_17"
                     /sec_met_domain="OAD_gamma (E-value: 1.1e-15, bitscore:
                     48.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILIDNQSNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGKKLLDQIVVPAGALGPNQSYARVSDGAAEW
                     EVKSGSGDKYVTPSTNNKTLDSNSKMEKFEEHDADGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             12964..13395
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.7; E-value:
                     2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_18"
                     /sec_met_domain="Biotin_lipoyl (E-value: 6.5e-22, bitscore:
                     67.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPV
                     AKPVTVRPMPNAPAAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVNKGDSVLEGNDLVIIE"
     CDS             13544..14557
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_19"
                     /sec_met_domain="OAD_beta (E-value: 7.7e-143, bitscore:
                     466.0, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGW
                     YPPLIFLGIGAMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIG
                     GADGPTAIFLSSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKNERVIRMKPPRA
                     VSHTEKVIFPIIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTIT
                     ILLGLTVGASTQASEFLTLDSIKIFALGALSFVIATASGVIFVKIFNIFLKKGNKINPL
                     IGNAGVSAVPDSARISQVIGLEYDSTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(14742..15191)
                     /locus_tag="ctg73_20"
                     /transl_table=11
                     /translation="IGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFEVLDAVMEKLPGFP
                     IVLHGSSSVPEEEVETINKYGGALKAAIGIPEEELRKAAKSAVCKINIDSDSRLAMTAA
                     VRKVFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSDNKLAQ"
ORIGIN
        1 caagccatga gctttcagta cttgctccac tacatcacgt ccgcaaccac gtccgccgtc
       61 tgcataagag atatactttg ctacggattt cacttccggc acggcatctt tcggacaaca
      121 tggaagtcca cattcacgca tcacttcaat atccggaaca tcatcgccca tatagagaat
      181 ttcatcatcg gtcagtccgt atttatcacg aaaatcacga tagtcgtgta tcttgacggc
      241 agatcccata tacagatcct tcacgcccag tccttcaaaa cggatacgca ctgcttctgt
      301 acggccaccg gtgatgatgg ctatgtgaag tcctttcttc acagccaact ggatggcgta
      361 cccgtctttg atattcacag tacgcatcgg ctctccggaa ggatgcaaag gtacggttgt
      421 cgaactcaat actccgtcta cgtcaaaagc taaagccttg atacgggata aatcatagtt
      481 gatggtgctc atggatactt ttgctcatta gtttatatat ttcctgcaat gccggagaat
      541 ctaccaacat ggcaagatga ttgttcatca cattctcatc gtaacggaca gcgggtccgg
      601 tctgtgcatc acgtggtgcc agctcgtgta ctttacgtgc cgtttcgtct atcagcggaa
      661 gcatgacatc gaaaggtaag ttgtattttt caagcaaatc agcagctaat gcatacatgt
      721 gatttgtgaa gttgcagata aaaacagcag ccaaatgaag gcttttacgt tgctcagaag
      781 aagcttcgta aactttctct gaaagagtgg cggcaacagc tttcaagaac tctacatctt
      841 ccggtcgttt cgcttcaaca aagaaaggca cttcctgaaa attgacttca cgttgtttgc
      901 tgaatgtctg catcggataa aatactccat accgttctgc atgcccttcc caaatactca
      961 tcgggatact tcccgcggta tgcaccaaca aagaactctg tttcccttct gttatctgcg
     1021 gcaacaaatc tactaaagcg gcatctttca aagatacgat atacaattta gcatctttgg
     1081 agatttcctg taaatctgtt gtatattcag cttcaacttt ctcggctaaa gtacgggcag
     1141 attccatggt ccggctatat acctgcacaa tacggaagcc tttatgatag agagccttcg
     1201 ccagattagt agccagatta cctgcgccga taaacacaat cggtgtatct tctatacttc
     1261 tcttcattat ttccttaccg ttttgcaaac cagaataaaa tgatgccgac aatgagcaaa
     1321 gtcaatggca gcagataccc ggacaacgaa cccagcaatg acataaccaa gccgatattc
     1381 atcactagcc aaagaccaag taacacaaaa ccaattgatt tatcgcgttt gaaaataaga
     1441 aaacagatcg aagcatacaa taacatattg tctttattca tcacccaagg caacccgagg
     1501 gtagagaaat gaatcagttt atcaatcaga taaagtgctc cgataacgat aaaggtaaca
     1561 gcagtagcca aataagtatc tttgctgtta ctcgctttag cagctcccat atttattttc
     1621 ctccgaattt atttatgtga attttctccc attgaagatg ttcttcgttg aaaggtttac
     1681 gttccatccc tttatgtccg atagcaataa cggaaagaat ttgaagttgc agaggaatac
     1741 ccaggattcc atgaacaaat tcatcggaag gcattccagt agcagtgaaa cgttcgcgga
     1801 cctgcaccca gcagcttccc aagccgagat cttcggcctg caactgtatc atgatagaag
     1861 caatagaagc atcttcaatc caaacatcac tggccaacgg atcggccatt accacaattg
     1921 ccaaagcagc gtcggcaatg aatgaagaag cctgttcctt acaatgagac aattctttca
     1981 atacctcttt atcatcaatc actacaaact gccaactatt actacgtttg gaagaaggag
     2041 acatcaaagc tgctttcatc aacgtaacta cctgatcttg tgtcaactct tcatcggtga
     2101 acttccgcat actacgacgg ttctttatta attcactgaa attttccata ttatttccgg
     2161 tttcatttga ttaatgtatg caaagataat gcaaaccgag cgtaatagga aataaaagta
     2221 tctttttcat ttcttttgtc agaagggaat ctatgacatg aaaagagtgc caaatactcc
     2281 actaaatgaa gaatatattg tatctttgca cagataaata atttcattat gaaaaagcga
     2341 attacacaag acgattacat taaagcgaat cgtaaagcca gccgtgaggc agaaattgag
     2401 atgtacgggc accctatttg tcacaaacga gtgcaccagt caaagaaagt atataaccgc
     2461 agaaagataa aggcagccga taaaaagctg ccttattttt ttgccttcaa aatagcgtca
     2521 ctatcctcca gacatagcga cactatacaa taggaatagc gtcactatca tgataggata
     2581 gcgtcactat atttagggga ttaaaaaagc agtttatcta tttacctatt tacctatcta
     2641 tctaattatc tatacaatcc gcgttaattc cccggtcgta gaatcaataa taaatccgta
     2701 gactgtcaca tctgaaggga tcaaaggatg gcgtacaata aaatcgactg ttcctctcac
     2761 cgacttttcc gtatcttcga aaccatccag ccacgaatga aagtcaactc cgcagaaacg
     2821 catcatgtca atataatccg gattgattcc gcgtgctttc attttttcga gcatttcttc
     2881 actatgcatg tggcaagctc cacaatcaga atgagcaatc accattattt cctctacccc
     2941 caactcaaaa atagcaacaa gcaaactacg tatcacgcta ccgaaaggat gggaaataac
     3001 gccacctgca ttttttatca ttttcacatc gccattctta attcctaatg ctgctggcag
     3061 caaagcagtc agtcgggtat ccatacagga aagaatagct attttcttat cgggatattt
     3121 attggtaata tacgattcgt atcccttgtt ctcaacaaat tgcttgttgt aagctaaaat
     3181 ttcttctaac atagttccgc tttttaaaag ttctgttcga ttacacaaag atatataaaa
     3241 aagggacata tcatcacgac atatcccctc tttaatctaa atttaatctg taagagtact
     3301 aatacccatt gtttccatat tcttctgcat tatcaatctg actcaagaag ttaaaagaaa
     3361 tcggacgcaa ataatgcttg ttttcatcaa aattttcagc tgcacgagga ttaccaacag
     3421 caagacgttg tttgaaagaa tctttgtgac gcttcatcaa tacccaacgt tgatattctc
     3481 cacacagttc acgagcatat tcatccataa catcattctg tgtagcatta ctcaatttca
     3541 tagcattgta agatgcatca ttgcgagcgg cacgtttttt cagtacattt aaatattcag
     3601 ctgcttttcc gccatttcct aattgttggt tagcttcagc tgcaatcaga tatacttcag
     3661 ccatacgcat aatgaacaca tcacctgtct tacgttgcaa attgctacta tatgaatctt
     3721 ccgacaacca attgtatttg ttgaaaccag ggtacatatt tttgtcatta gtgactttta
     3781 tatctgtttt acgatattgt ccgttatcaa acaaatcatc aatattgatt acataatatc
     3841 tacgtttcgc tttctccgca tccgaaagtc tttcctttga taagtagaaa cagattctat
     3901 catcatcttc agctacaggg taaggtatca cataggggtt cttcacttcc tgcaatttgg
     3961 aaggatcacc gctattttca cctttcggcc aaaccttggc tatcattttg ggcgcccaag
     4021 ttccatcata atatgtataa ttcaaatcac cataaggata aatatactca ttatggaatt
     4081 ttgcatccaa tccataagta tcgattatat tttgagtaag aattgtaaat gaactaatat
     4141 tatcatttac gccatgtttt gttccaattt ttggttttgt accatcatcc aatgtctgct
     4201 tcttattagt aaataaataa ctacctcctg actgtacggc agaaaactgt acaaaagccg
     4261 tagtaaaggt tacttcccac cgcttatcat aatcagcatc aaaacaatcc agcaaatatt
     4321 tggaaggtgc caacgtatta ttattagtac gtccatacca ataattttga ttatccggag
     4381 taggataaat agtgagagta tttggctttg gatacatata agtaaagttg ttattacatt
     4441 gtgttccagc attccagttc tccaaattcg tagcatccgg accggcagca ataaataaag
     4501 cttctttatt atttcgatta tttgccggag cccaaacatc ttccacatca tcatacagac
     4561 agtcaccata cgctaaaatc atgtcctctg ccacttcttt agcacgttgc caataagata
     4621 ctccctcttc tgtcagccca tattcgccac caccttgagc ataaacgcga gccaaaagtc
     4681 ctaacgcggt tttcttagtc acacgcgcac gattattatc ataaggagta tcttcaagat
     4741 tattggccgc aaatttcaaa tcatcaatta tctgcgtata tagttcttca atagagttac
     4801 gctgcggagt caaaatagga tcttgagacg attcttccaa tgttaacgtt acattcccat
     4861 acgtattcac caatatggaa taataaaacg cacgaagaca gcgggcttca gccactaacg
     4921 tcgttatatc tttttcattg ccatccgtta gtaattcagc cctgtttact actgcattac
     4981 aattaccgat catagaataa gcctgaccga ataatttatt tgtagcattc gtattcgtag
     5041 ctaaaccatc ataataaatc acctgcttgg cataatccgg attaccggca ggagttatcc
     5101 agcagtccgt accaccttca gccacagaca agaaatcata gacactgaat aactgcccgt
     5161 aaagtgatga ataacaataa gactgtaatc ctttaagccc atcgaacgtt gcaagaattt
     5221 catctcctgt tttttggctt ggattatact catcaagcga gcaggcagac attgaagcca
     5281 cagcgaatgt aagcgctgct attttataga ttgtactttt catttcaata ctttttttag
     5341 tgaaaaacta gaatgtaaca tttacaccaa atacaaattg tttggtcaat gggtacttca
     5401 gagaaccatt catttcggga tcatagtctt tcagcaaatg gcttttcgca aatacaaacg
     5461 gatttgtaat ggtagcatag aaacgacact tctctatacc ggctgatttt aagatagatt
     5521 tcggcagact atatcccaat gtaatgttct taatctttat aaacgaaccg tctacatagc
     5581 gtaatgcgta atatcccgta tattgttcga gacctttatt agcattggcg gcaggaaaat
     5641 catttgaagg gttgttttca gtccaataat taaaataggt cgggaagtta cgtataccct
     5701 tcgggtcata agacgtcaac atatcataag caaacatctg tccgtaacgt gcataaacaa
     5761 acacacttaa atcaaaatcc ttccaggtaa aattattctg gaatcctaaa gaccaatccg
     5821 gagagttgtg acccagaatt tgataatctg catcacttgg agtatattta ttatcagaag
     5881 tgtaataaat aacattacca ttttcatcta cagcagcact acccgtttct tcatctattt
     5941 tatagaatct accatcagat tcttttacta aattaggtat attgattttc aaatcaccag
     6001 gtgcagcacc aaataccgcc gcatcagttt cctcaccttt ttgccataca ccatccaact
     6061 tataatgata ataagagtta atagcttctc ccaatgccaa tgcataaccg gtgtcaccat
     6121 tattaagcac atctgaatct ccaccggaca atttggttat tttctcttta ttatgattga
     6181 aagttacact tgaactccag gtaaagttct ttgttataat attacgtgta ttaagagcca
     6241 actcaaaacc tttattgcta gtctcacaca tatttaaatt agtagtataa ttcgctttag
     6301 gtccgccatc cggggagaat gctccattaa taacaggaag tgccttgttc catataacat
     6361 cttttgtttt tgtattataa tattccatac tgacatcaat gcgattattt aagaatgcag
     6421 cgtcaatacc aatattcgtg ttatacgact tttcccatgt aagcaaatag ttcggaatat
     6481 tctgtgagaa tttataaatc ggcgtcagaa cacctcctaa tatcatattt acagcagtag
     6541 catccaatga tgcagcagac gaatacggat caatacccgc tgtactaccc gtaacaccat
     6601 atccgaagcg aattttcaga ttactcaacc agttagtcgt actctccata aatttttcat
     6661 cagagattct ccatcccaaa gaaaaagccg ggaaagtatc ccatttatta ccttctgcca
     6721 gtctggaaga gccgtcatgg cggacagatg cagcaaataa atacctaccc atatatgaat
     6781 agttcaaacg gccgacatat cccatcccct tagacatact ataagaagta cttcccgaag
     6841 ttgcggaatt accatcaaga atattatgcc ataagaattt attatcagaa acaccttttt
     6901 gatacaaagt agtgacatcg ctacgattgt gattccaaga tgtaactgca gtaagagtta
     6961 tatcatgcac tttcttaatc tggaaattgt aagtaagtat attttcccac ttataattat
     7021 acgaacggtt gtccttaact tgcgccttaa tgccgtctgc cgtttgattt gccttatacc
     7081 attgaacaga cccctctcct gtgaaagtgt tactacgtga atatcccaaa ctagcaccag
     7141 cacgagtaat aaaagtcagc cctttaagag gagtgatttc caagtaagga ttaaaataga
     7201 ccttaaggtt ttgagcctga ttgcggtaca aacttttatc ctcatttaaa agataattat
     7261 atactgtaga tgaaggatcg gcaacaggtt gcggattgat gcttccatct tcattataca
     7321 acgatccaag aggatttgac gccatcaaag tctgtaaatc agaatcagct ttattttgat
     7381 gtacataaga cagttgagca tcaatgccca ccttcatcca ctttttaatc ttatgatcta
     7441 cccggatttt agatgaataa agtttatagc tatcttgtgc aaactgccca tcctcattag
     7501 agaagttcag agaaaaatat gcctttgtct tttccgttcc accagccaca gaaacagaat
     7561 aattctgtgt tacactggtt ttcaacaaag catccaccca atctatatat tggccatttt
     7621 gatgtgcact ccattcagca tcagtagtaa acagattttt atcatcagca accgaactcc
     7681 aacgtccatc gccagcacca acagatgcat ctctcaaggt ttgtatataa ctttctccac
     7741 tacgcatctc cggagtcctt gaccagccgt ttacacctac gtatgcatta aaattaacaa
     7801 ttgctttgcc ttccttacca cctttagtag taattaaaat aacaccgttc gcaccacttg
     7861 aaccataaat agctgtcgaa gaagcatctt ttaaaacttc aatgctttca atatcattcg
     7921 gattcaatgt agaataatcc cccggcatac catcaattat aaataaagga tttccggaat
     7981 ccttctggaa tgaccggtta ccacgcaact gcatctttac tcccgaaccg gcctgtcccg
     8041 attcacgcgt aatatccaat cctgccacct taccttgtaa agcctgcatc ggatttgaac
     8101 ttggattcat cactacatct tcacttttta cagaagtgat agctcctgtc aaatcgcgtt
     8161 ttttcatcgt accgtaaccc acaacaacca cttcatccaa tgcctgtgtg tccgaaacca
     8221 ttttcacatt gaccggtccg ttgcctgtca ctgtcaccgt ttgttctttg taaccgatat
     8281 aagaaatgac cagttctttt cttcccgccg gaagatcgat agagaagtta ccgttaaaat
     8341 cggtaatcgt acctgtactt gttcctttca caacgataga aactccaatc agcggctccc
     8401 cgctttcatc aatgatagtt cctttcacag ttttcgtttg tgtgacaact tgcaccatag
     8461 tattagaaac tccatcttct gcatacacag aatatgacag aggggcagac aataaagaca
     8521 gccctaaaat catggaagcg cgtctatgat gattcttcca tgcttcaaca aatgcattac
     8581 atcgcattcg ttctaattta aagttaatat taattctcgt tgttttgcaa aaactattcg
     8641 attataatct taattaaaga cgaatctaat tttaatacgt actcactttt cataccatat
     8701 ttctcctata aaatatattt tctccattaa atacgcaact atatattata ctttacttca
     8761 agcagctcca acaaattctt tgttttgttg ttgaataaag aataaaaagt gtaaatttgt
     8821 acctagatgc cacttaaact aaccacatat tatcatggga aggacattcc tgaattacca
     8881 ggaaaaaacg ccttccattc caaagagtta tttcagattt atgaagcgac tccgggctat
     8941 actcctttat taatagtggc aacagaagac ggcagaccta tggcacgcct gcttgccgcc
     9001 atccgcaaag cgaaaaagtg gcttccctcc tctttagtga aacattgcgt agtatatagc
     9061 gaaggtgaat ttctggatga gtcgctttcg accaacaaag aaaaggcaga agaagtcttt
     9121 ggcgatatgc tcgaacatct cacacaagaa gcatcgcgta gctgtgtcct gatcgaattc
     9181 cggaacctca ataattcgat gttcggttac cgggttttcc gtgccaatga ttatttccct
     9241 gtcaactggc tgcgggtacg caattcgctg cacagtatga aaaagacgga agaccggttc
     9301 agcccgtcgc gcatccgtca gataaaaaaa ggactcaaga atggagccaa agtagaggag
     9361 gcacataccg tggaagaaat acacgatttc tcacggatgc tgcacaaggt ttattcctcc
     9421 cgcatacgca gatatttccc tgccaacgac tttttccgcc acatgaacaa tatgttaatc
     9481 aaaggacaac aggcaaaaat attcgttgtg aaatacaaag agaaaatcat tggcggttct
     9541 gtctgtatct attcgggaga cgacgcatac ctttggtttt ccggaggaat gagaaagaca
     9601 tacgcacttc aatatccggg tgtgctagcc gtttggaaag cattggaaga cgcacaccaa
     9661 cggggattcc gccacatgga atttatggat gtaggacttc cgttccgtaa acacggttat
     9721 cgtgatttcg ttcttcgctt cggaggaaaa caaagcagta cccgccgttg gttccgcatc
     9781 aattggagtt ggctgaacaa actcttagtc aagttttatg tctaaatgta atctcaagat
     9841 tacaaaacaa tgttttatgc tcctttccca ccattttttc tgtttaataa tccaataatt
     9901 aaatgcagaa atatttcttt attagataag aaatgtcttt ctttgtgctg ttttatgcct
     9961 tataagcaca gatttaaaac caaataaaaa aagtatagtt atgaagattt cacacattga
    10021 acatctgggc attgctgtaa aaagcatcga agaagccctt ccttactacg aaaatgtatt
    10081 aggtctgaag tgttacaaca ttgaaacagt ggaagatcag aaagtaagaa ctgctttttt
    10141 aaaagtaggc gaaacaaaaa ttgaactgtt ggagcctact tgcccggaga gtactattgc
    10201 caaattcatt gaaaacaaag gtgcaggcgt tcaccacgtc gcatttgctg tagaagatgg
    10261 cgtagccaat gcgctggcag aggcagaagg caaagaaatc cgccttatcg acaaagctcc
    10321 ccgcaaaggt gctgaaggtt tgaatatcgc tttccttcac ccgaaatcaa ctttgggtgt
    10381 gttaacagaa ctctgcgaac attaatcata aactctaaaa ccaacaagaa ctcatgagta
    10441 atcaacttga aaaaattaaa gagcttattg aacgccgtgc cgtagcacgt atcggaggcg
    10501 gtgaaaaagc aattgcgaag caacatgaaa aagggaaata cacagcacgc gagcgtctgg
    10561 ctatgctgct tgacgagggt agcttcgaag aaatggacat gttcgttgag cacagatgca
    10621 cgaacttcgg tatggagaaa aaacattatc cgggagacgg tgtagtaacc ggctgcggta
    10681 caatcgaagg acgtctggta tatgtgttcg cacaggactt cactgtttct gccggttcac
    10741 tgtcagaaac gatgtcattg aagatttgta aaattatgga tcaggccatg aagatgggtg
    10801 ctccttgtat cggtatcaac gactcgggtg gtgcacgtat ccaggaaggt atcaacgctt
    10861 tggcaggtta tgcagaaatc ttccaacgca acatccttgc ttcaggtgtt attccgcaga
    10921 tttccggtat cttcggtcct tgtgccggtg gtgctgttta ttctccggct ctgaccgact
    10981 tcacactgat gatggaaggc acttcttata tgttcctcac cggaccgaaa gtggtgaaga
    11041 ccgttacagg tgaagacgtt agccaggaaa acctcggtgg cgcaagcgtt cactccacta
    11101 aatcgggtgt aactcatttc accgcccaaa cagaagaaga aggtttcgaa ctgattcgca
    11161 aactgttgag ctatattcct caaaacaacc ttgaagaagc tccttatgta gattgcacag
    11221 acccaatcga ccgtctggaa gactctttga acgatattat ccccgacagc cctactaaac
    11281 cgtatgacat gtacgaagtg atcggcgcta ttgtggacaa cggtgaattc cttgaaatcc
    11341 agaaagatta tgcaaagaat atcatcatcg gtttcgcccg tttcaacgga caatcggtag
    11401 gtatcgttgc taatcagcct aagtatctgg ctggtgtgct cgacagcaat gcatctcgta
    11461 aaggcgcacg tttcgttcgt ttctgcgatg cattcaatat tcctatcgta tcgttggtag
    11521 acgtaccggg attccttccg ggaacaggtc aggaatacaa tggcgttatc cttcatggtg
    11581 ctaaactgtt gtatgcttac ggtgaagcta ctgtacctaa ggttactatt acattgcgta
    11641 aatcttacgg tggttctcac atcgtaatga gctgtaagca acttcgcggt gacatgaact
    11701 acgcatggcc tactgccgaa atcgcagtaa tgggtggtgc aggagcagta gaagtattgt
    11761 acgcacgcga agccaaagat caggaaaacc ctgctcaatt ccttgcagag aaagaagcag
    11821 aatacacgaa actgttcgcc aatccttaca atgcagctaa atatggctac atcgacgatg
    11881 tgattgaacc gcgcaacaca cgtttccgtg ttatccgagc tttgcagcag ttgcagacta
    11941 agaaattgag caatccggct aagaagcatg gtaatattcc gttgtaatcc tacttttcac
    12001 attaaaacaa gaacgattat gaacaaaacc aaaatcggaa tattcctttc tttgctgttg
    12061 ctgattggtt tgacttcttg tggagagcaa aagtcgaaca ataagctggt gctaaacgaa
    12121 atcctgatag acaatcagag taattttcag gacgattacg gattgcacag cgcatggatt
    12181 gaaatattca ataaatcatt cggtagcgcc gacctggcag cttgcttgct gaaagtaagc
    12241 agccaaccgg gcgatacagt tacttatttt atcccgaaag gtgatatact taccttagtg
    12301 aaaccacgcc aacatgcact attctgggca gatggcgaac ctaaccgtgg tactttccat
    12361 accagcttca agctgaatcc ggaaacagct aactgggtgg gtctgttcga ctccggcaaa
    12421 aagttgctcg accagattgt agtgcctgca ggcgctctcg gtcccaacca atcatacgct
    12481 cgtgtaagtg acggggcagc tgaatgggaa gtaaaaagtg gaagcggtga caaatacgtg
    12541 actccaagca ccaacaacaa gactcttgac agcaattcca agatggaaaa gtttgaagaa
    12601 cacgatgctg atggcgttgg aatgtccatt tctgccatga gcgtagtatt ctgcggattg
    12661 attcttctct ttattgcttt taagattgta ggaaaagtag ctgttaattt gagcaagcgc
    12721 aacgctatga aatctaaagg cattgacaag catgaagcta aggaactgtc acaggctccg
    12781 ggcgaagtat acgctgctat ttctatggca ttacacgaaa tgcaggatga ggtgcacgac
    12841 gtagaagaaa cggtactgac catcacccgc gtaaaacgca gctactcacc atggagttcg
    12901 aagatttaca ctttgcgtga aactcctccc agaaagtaag tcacctttta aaaagtaaaa
    12961 acgatgaaag aatataaata taaaatcaac ggtaactcat ataaagtaac catcggagat
    13021 attgaagaca acatcgctca tgtagaagtg aacggtacac actataaagt agaaatggag
    13081 aaacagccga agcctgttgc gaaacccgtg acagtacgcc cgatgcctaa tgctcctgct
    13141 gctcctactc aagtagtgaa accgaccgct ccgtctaccg gaaaatcagg agtaaaatct
    13201 ccgctgccgg gtgtgatcct cgacatcaaa gtgaatgtag gcgatactgt aaagaaagga
    13261 cagaccatta tcatattgga agccatgaag atggaaaaca atatcaatgc ggataaggac
    13321 ggtaagatta ctgccatcaa cgtcaacaag ggagactctg ttcttgaagg taatgacctc
    13381 gtaattattg aataatatgg gagactttat aaacttttta ggaaataacc tggccgactt
    13441 ctggacatac acaggctttg ccaatgctac ggtagggcat gtagtcatga ttctcgttgg
    13501 cttggtattc atctatttgg caatagccaa agagttcgaa ccaatgctgc tgattcctat
    13561 cggttttggt atattgattg gtaatatacc ttttaatatg gatgccgggc tgaaagtcgg
    13621 tatttatgaa gaaggttctg tattgaatat attgtatcag ggagtgacct ccggctggta
    13681 tccgccgctc atctttttgg gtatcggtgc catgacggac ttctcggcac ttatctctaa
    13741 tccaaaattg atgctgattg gtgcagctgc acagttcggt atcttcggtg catatatgat
    13801 cgcattggaa atgggtttcg acccaatgca agccggtgct atcggtatca ttggtggagc
    13861 agacggcccg acggccatct tcctttcttc caagctagca cctaacctga tgggagccat
    13921 tgcggtgtcc gcctactcct atatggcgtt ggttccggtg atacagccgc ctatcatgcg
    13981 tctgctcacc accaagaacg aacgtgtcat ccgcatgaaa ccgccacgtg ccgtttctca
    14041 cacggagaag gtgattttcc cgatcatcgg tttgttgctg acttgtttcc tggttccttc
    14101 cggtctgcct ttgttgggta tgctgttctt cggtaacctg ttgaaagaaa gtggtgtaac
    14161 ccgccgtttg gctaatacag ccagtggtcc gttgattgat acaatcacta tcctgttggg
    14221 tctgacagta ggtgcttcta cacaagcatc cgaattcctg acgcttgact ctatcaagat
    14281 ctttgccctc ggtgcattgt catttgttat tgcaacggca tccggtgtca tcttcgttaa
    14341 gatcttcaat atcttcctga agaaaggtaa taagatcaat ccgttgatcg gtaatgcagg
    14401 tgtttctgct gttcccgact ctgcacgtat ctcgcaagtg attggtttgg aatacgattc
    14461 gaccaactat ttgctgatgc acgctatggg tccgaacgtt gccggagtga tcggttcagc
    14521 tgttgctgcc ggtatcctgc ttggattctt gatgtaagaa acattatata atagataaga
    14581 acacccgtgt tacattcagt tgtgacacgg gtgttcttta ttacagccat agtgttatct
    14641 tctctccgtt ctgaaacgat taaacgtcat aaaaaaggct gccaccggtg ttcaaaccgg
    14701 agcagcctct ttcttttatt tatggaataa tccggagatt attactgtgc caatttgttg
    14761 tcagaaccga gcacgttgat gattttgtgc ttgtacagtt tttccatatt gtcacgagcc
    14821 gggccaagat acttacgtgg gtcgaattca gccggttttt cagcgaatac cttacgtaca
    14881 gcagcagtca tagccagacg agagtcagag tcgatgttga ttttgcaaac agcagactta
    14941 gcagctttac gcaattcttc ttccggaatg ccgatagcag ctttcagtgc accaccatat
    15001 ttgttgatag tttccacttc ttcttccgga actgaagatg atccgtgaag aacgataggg
    15061 aatcccggaa gtttttccat tacagcgtcc aatacttcga aagccaatgg aggaggaacc
    15121 atacggccag tcttcgggtc gatgtggcat tgttccggag taaatttgta agcaccgtga
    15181 gaagtaccga ttg
//
