LOCUS       gnlProkkaLPLPJMKM_176   8487 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LPLPJMKM_176.
ACCESSION   gnlProkkaLPLPJMKM_176
VERSION     gnlProkkaLPLPJMKM_176
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 08:46:09
            Original ID  :: gnl|Prokka|LPLPJMKM_176
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8487
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..8487
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[1557:8487]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1558..8487
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..8487
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8487
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             2..796
                     /locus_tag="ctg176_1"
                     /transl_table=11
                     /translation="MIARAMREWVAGSSSVRKRENELYCRHTEKIFEHKVQPYYSLRCV
                     PQILGPVFDEMVNAEKVLIDELNSACDNPIVDLETENVYHGGNFHGDYISFEMDKLKIA
                     VTKLTMLTERQLNYLFHDRINGILPPFVNLGVLGLNYGLQASQFTATSTTAESQTLSNP
                     MYVHSIPNNNDNQDIVSMGTNSALLAKTVIENGFQVMAIHFMAIVQAVDYLKIQDRLSP
                     RTKDIYNEIRSFFPVFTEDTPKYKEIETMIEWLKNKNLEPIA"
     CDS             793..1521
                     /NRPS_PKS="Domain: PKS_KR (3-170). E-value: 5.1e-17. Score:
                     54.2. Matches aSDomain: nrpspksdomains_ctg176_2_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     218.7; E-value: 1.4e-66)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg176_2"
                     /sec_met_domain="adh_short (E-value: 8.1e-36, bitscore:
                     113.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYALVTGGSRGIGRAVSVRLAEMGYALLINYQSNDTEAEHTLQL
                     VREKGSDGELLKFDVTDAAAVTAALNGWTEAHPDAYIEVLINNAGIRKDNLLLWMAGEE
                     WHRVLDISLSGFFNVTQPLLKDMLVKRFGRIVNIVSLSGIKGMPGQTNYSAAKGGIIAA
                     TKALAQEVAKKKVTVNAVAPGFIRTDMTGDLDEAELKKLVPAGRFGEPEEVADLVAFLV
                     SPAASYITGEVISINGGLYT"
     aSDomain        802..1302
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg176_2_PKS_KR.1"
                     /evalue="5.10E-17"
                     /label="ctg176_2_PKS_KR.1"
                     /locus_tag="ctg176_2"
                     /protein_end="170"
                     /protein_start="3"
                     /score="54.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVTGGSRGIGRAVSVRLAEMGYALLINYQSNDTEAEHTLQLVRE
                     KGSDGELLKFDVTDAAAVTAALNGWTEAHPDAYIEVLINNAGIRKDNLLLWMAGEEWHR
                     VLDISLSGFFNVTQPLLKDMLVKRFGRIVNIVSLSGIKGMPGQTNYSAAKGGIIAATKA
                     LAQE"
     CDS_motif       805..867
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg176_2_0001"
                     /evalue="6.00E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg176_2"
                     /protein_end="25"
                     /protein_start="4"
                     /score="15.7"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRAVSVRLAEMG"
     CDS             1558..2757
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (70-397). E-value:
                     1.1e-51. Score: 168.0. Matches aSDomain:
                     nrpspksdomains_ctg176_3_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 289.5; E-value:
                     7.3e-88)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg176_3"
                     /sec_met_domain="APE_KS1 (E-value: 2.1e-157, bitscore:
                     513.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGIYSCIGKNLEEVKTSLYKGKSGIGIDPVRKEFGYRSALTGLLD
                     KPNLKGVLDRRQRIGLPEQGEYAYLATAEAFAQAGIDEEYLLNHEVGILYGNDSSTAPV
                     INAVDIIREKRNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTISGACASGSHAIGM
                     GYFLIRSGIQDCIVCGGAQEVNMYSVGSFDGLAAFSVREDEPGKASRPFDKHRDGLVPS
                     GGGATVIIESYESAKRRGANILAEVVGYGFSSNGEHISVPNVDGPRRSLEMALKDSGLA
                     ARDIQYVNAHATSTPLGDLNEAKAIAAVFGETSPYVTSTKSMTGHEMWMAGASEVIYSM
                     LMMQNGFIAPNLNFTEPDEASALLNIPAETKQLEFDTFLSNSFGFGGTNSTLIIRKFKS
                     "
     aSDomain        1768..2748
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg176_3_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.10E-51"
                     /label="ctg176_3_PKS_KS.1"
                     /locus_tag="ctg176_3"
                     /protein_end="397"
                     /protein_start="70"
                     /score="168.0"
                     /tool="antismash"
                     /translation="ATAEAFAQAGIDEEYLLNHEVGILYGNDSSTAPVINAVDIIREKR
                     NTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTISGACASGSHAIGMGYFLIRSGIQD
                     CIVCGGAQEVNMYSVGSFDGLAAFSVREDEPGKASRPFDKHRDGLVPSGGGATVIIESY
                     ESAKRRGANILAEVVGYGFSSNGEHISVPNVDGPRRSLEMALKDSGLAARDIQYVNAHA
                     TSTPLGDLNEAKAIAAVFGETSPYVTSTKSMTGHEMWMAGASEVIYSMLMMQNGFIAPN
                     LNFTEPDEASALLNIPAETKQLEFDTFLSNSFGFGGTNSTLIIRKF"
     CDS             2776..3021
                     /NRPS_PKS="Domain: PP-binding (8-75). E-value: 2.1e-11.
                     Score: 36.1. Matches aSDomain:
                     nrpspksdomains_ctg176_4_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg176_4"
                     /sec_met_domain="PP-binding (E-value: 4.2e-12, bitscore:
                     36.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASTELIQKINEKLSEEFEIDIELIQPDAPLMQTLELDSLDLVDM
                     VVLVEHNFGFTLKAQDFIGIKTFQDFYDFIDSRVNG"
     aSDomain        2800..3000
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg176_4_PP-binding.1"
                     /evalue="2.10E-11"
                     /label="ctg176_4_PP-binding.1"
                     /locus_tag="ctg176_4"
                     /protein_end="75"
                     /protein_start="8"
                     /score="36.1"
                     /tool="antismash"
                     /translation="KINEKLSEEFEIDIELIQPDAPLMQTLELDSLDLVDMVVLVEHNF
                     GFTLKAQDFIGIKTFQDFYDFI"
     CDS             3014..3913
                     /locus_tag="ctg176_5"
                     /transl_table=11
                     /translation="MGDSNDTGWKGKTRGGSFGYLFFILLIKGLGVKAAYAFLCLVVVY
                     FVPFAPKATRAIWKYARQRLGHSRFRSACFLLKNYYRLGQTLIDKVAVGAGMAKQYTFD
                     FGAQYPGFLEVLNGNEGVVMIGAHVGNWEIGAPFFDDYGKKMNIVMFDAEYQKIKELLE
                     KNTNGKNYKVIPVNEDNLTHIFRIRDVLANGEYVCFQGDRYVEGAQTFKETFLGAEASF
                     PAGPFLLASRLGVPVVFYFAVREKGMHYKFNFVLAQPEKRVKGVVPGQGLLKQYVSALE
                     SVVKQYPEQWFNYYDFWK"
     CDS             3934..5019
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 133.5; E-value:
                     1.7e-40)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg176_6"
                     /transl_table=11
                     /translation="MELSSPQKEIYAKDRFSAVQAQRLAQEIAFGPVVFQVSRLMVKFG
                     IFGMLREAQDGLTMDEIAEKTGLSHYAVQVLLESSLTIGTILLKDGHFHLGKAGWFLLN
                     DEMARVNMDFNHDVNYLGLFRLEEALLNGKPEGLKVFGNWPTIYEGLSSLPEKVQASWF
                     GFDHFYSDNSFKQALEIVFANPVRTLLDVGGNTGRWAMQCVAYSPEVEVTIMDLPQQLE
                     MMREQTRELEGAARIHGHAADLLDDGTSFPQPFDAIWMSQFLDCFSEEQVLSILSRAAR
                     SMEAGSRLYIKETFWDRQRFETASYCLAQTSLYFTAMANGNSKMYYSADMARLVEKAGL
                     AIEQIHDGLGLGHSIMQCKLK"
     CDS             5022..5471
                     /locus_tag="ctg176_7"
                     /transl_table=11
                     /translation="MASISFDTPLLSGDGLLDLIPQRAPIVMVDRFFGMDDYGSYTGLE
                     VEDSNLFCQDGQLDECGITEHIAQSAAIRVGYLYRCAGEKIPVGFIGSVNKMNFYALPQ
                     VGDELHTTIRVEQEIFDITLISATVQVNGTTVADGQLKIFLKKDA"
     CDS             5546..5911
                     /locus_tag="ctg176_8"
                     /transl_table=11
                     /translation="MEVVWHGEYVRYMEDGREAFGRQYGIGYTEIRDAGYVVPIVELNI
                     QYKQSLKYGESAIVETRYIRTEAAKILFEYIIFRESDGAVVATGSSTQVFVDSRTGELE
                     LNNPDFYQAWREKWNIG"
     CDS             5896..7743
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (149-405). E-value:
                     3.4e-28. Score: 90.5. Matches aSDomain:
                     nrpspksdomains_ctg176_9_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 187.3; E-value:
                     8.1e-57)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg176_9"
                     /sec_met_domain="APE_KS2 (E-value: 3.5e-101, bitscore:
                     328.5, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYRVNSYITAGSIISSLGFGTEENFSRIREYRSGIARVEDTTLF
                     DTPFMAARIDDTRLKVLAQELDGYTRMEQLFILSLSDTIRQSGIDPTQSDCGLIISTTK
                     GNIDMLSGSHDLPTQGVETSQSWEDILPSTRKTDFPGKGRASSQLYEMAMCVAGYFGCV
                     NEPIVISNACISGVSALIVASRLIEAGKYKHILVAGGDLLTRFVVTGFQSFKSVSPEIC
                     KPYDKARDGLSLGEACGSVLVTSDRGLVGEEQPVSIAGGSITNDANHISGPSRTGDGLY
                     YAISQAMDEAGLQQEAISFVNAHGTATLYNDEMESKALHWAGLDQLPLNSMKSYWGHTL
                     GASGIIEVIACVEELRSGEVFGTFGFETCGVPYPLSVSAAHRKVAMAHCVKTASGFGGC
                     NAAVVLSLERKSFDTPPAPSREGKGYSWRTVVIERGKIVLDGEVLLETDSAGAFATFIR
                     AAYKFLALDDRKFYKMDDLCKLGYIAAACLFARNGGKTGYEPGEVGIICANASSSMDTD
                     RKHQHIIDTMGDQEASPAVFVYTLPNVVLGELCIRYKIQGENTFFINNRYPESFIRDYA
                     TLVMRKQKLRACLTGWCELLGDRYEARFDWLEQTTIANE"
     aSDomain        6343..7110
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg176_9_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.40E-28"
                     /label="ctg176_9_PKS_KS.1"
                     /locus_tag="ctg176_9"
                     /protein_end="405"
                     /protein_start="149"
                     /score="90.5"
                     /tool="antismash"
                     /translation="YEMAMCVAGYFGCVNEPIVISNACISGVSALIVASRLIEAGKYKH
                     ILVAGGDLLTRFVVTGFQSFKSVSPEICKPYDKARDGLSLGEACGSVLVTSDRGLVGEE
                     QPVSIAGGSITNDANHISGPSRTGDGLYYAISQAMDEAGLQQEAISFVNAHGTATLYND
                     EMESKALHWAGLDQLPLNSMKSYWGHTLGASGIIEVIACVEELRSGEVFGTFGFETCGV
                     PYPLSVSAAHRKVAMAHCVKTASGFGGCNAAVVL"
     CDS             7772..8020
                     /NRPS_PKS="Domain: PP-binding (3-76). E-value: 2.2e-11.
                     Score: 36.0. Matches aSDomain:
                     nrpspksdomains_ctg176_10_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg176_10"
                     /sec_met_domain="PP-binding (E-value: 4.4e-12, bitscore:
                     36.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQELKEALIESLNLEDITPDEIDNEAPLFGDEGLGLDSIDALEII
                     LILERNYGIRIANPAEGKSIFYSVRTLADFITANRTK"
     aSDomain        7781..7999
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg176_10_PP-binding.1"
                     /evalue="2.20E-11"
                     /label="ctg176_10_PP-binding.1"
                     /locus_tag="ctg176_10"
                     /protein_end="76"
                     /protein_start="3"
                     /score="36.0"
                     /tool="antismash"
                     /translation="LKEALIESLNLEDITPDEIDNEAPLFGDEGLGLDSIDALEIILIL
                     ERNYGIRIANPAEGKSIFYSVRTLADFI"
     CDS             8017..8487
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg176_11"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.3e-11, bitscore:
                     34.1, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="APE_KS2 (E-value: 2.8e-18, bitscore: 55.6,
                     seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVCVTGIGCVSGIGLNVEEHLRSFRDGRDGLGAVTLFPTRHEEP
                     VSEVKRTNEALKEQLGIPVSAALSRTALLGMTAAFEALADSGLDLSDRDRPLRVGQISS
                     TSTGGMDLTESFYPSFRENPAQGRLRYVASHDAGDSTERIASFLGITGFRTTV"
ORIGIN
        1 gacgattgcc cgtgccatgc gtgaatgggt ggcgggaagt tcttctgtcc gtaaacgtga
       61 gaatgaatta tactgccgcc atacggaaaa gatatttgaa cataaggtac aaccatatta
      121 ttcgctgcgt tgtgtccccc agatactggg ccccgtattc gatgagatgg tcaatgcgga
      181 aaaggtactg atcgacgagc tgaactctgc ctgtgataac ccgatcgtcg acctggaaac
      241 ggaaaatgta tatcatggag gtaacttcca cggcgattat atctcttttg agatggacaa
      301 actgaagatc gccgtaacca aattaaccat gctgaccgag cgccagctga attatctgtt
      361 ccatgaccgt atcaacggta ttctgccgcc gtttgtcaat ctgggcgtat tgggactgaa
      421 ctacggattg caggcttccc agtttacggc aacttccaca acggcagaga gtcagaccct
      481 gtcgaatccg atgtatgtgc acagcattcc gaataataac gataaccagg atattgtcag
      541 tatggggaca aattccgccc tgctggcaaa aactgtcata gagaatggtt tccaggtgat
      601 ggcgatccat tttatggcaa tcgtacaggc agtggattac ctgaagatac aggatcggtt
      661 gtctccccgt acaaaggata tttataacga aatacgttct ttcttcccgg tgtttaccga
      721 agatactccc aaatacaagg agatcgaaac aatgatcgag tggttgaaga acaagaattt
      781 agaaccgatt gcatgaaata cgcattagta acaggcggaa gccgcggcat agggcgtgcc
      841 gtcagtgtca ggctggcgga aatgggatat gccctattga taaactacca gagtaacgat
      901 acggaggcag aacataccct gcaacttgtc cgcgaaaaag gatcggacgg cgaactgctg
      961 aaatttgacg taacggatgc cgcagcagtg actgctgccc ttaacggatg gacggaagcc
     1021 catccggatg cctatatcga agtgctgatc aataacgcag gcattcgcaa agataacctc
     1081 ctgctctgga tggccggaga ggagtggcac cgtgtgctcg atatcagcct gtcgggtttc
     1141 tttaacgtta cgcagccttt attgaaagac atgctggtaa aacgtttcgg gcggattgtc
     1201 aatatcgttt ccctgtctgg gataaagggg atgccgggac agaccaatta ttcggcggct
     1261 aaaggtggta ttattgcggc aaccaaagcg ctggcgcagg aagttgccaa gaagaaggtc
     1321 acggtaaatg ctgttgctcc cggttttatc cgtacggata tgaccggcga tctggatgaa
     1381 gcggagctga aaaaactggt gcctgcaggc cgcttcggcg aaccggaaga ggtggctgac
     1441 ctggtagctt ttcttgtttc gcctgccgcc tcgtatatta ctggcgaagt gatttcaata
     1501 aacggaggat tatatacctg ataataaaga tatatgaata gagttgttat tacaggaatg
     1561 gggatttact cctgcatcgg aaagaacctg gaggaggtaa agacttcatt atataaaggg
     1621 aaatcgggta tcggtatcga tccggttcgc aaagaattcg gataccgctc ggcattaacg
     1681 ggactattgg ataaaccgaa cctgaaaggc gtactggatc gccgccagcg tatcggtctt
     1741 cccgaacagg gcgaatatgc ttatctggca acggctgagg cttttgcaca ggcggggata
     1801 gacgaagagt atctgctgaa ccacgaagtt ggtatccttt acggaaacga cagcagtacg
     1861 gctcctgtga tcaatgcggt ggatatcatc cgtgagaaaa gaaatacggc gctggtcggt
     1921 tccggctcta tttttcagag catgaattcg acggtgacga tgaacctgtc ggttattttc
     1981 aagctgcggg gtgtcaactt tacgatctcc ggtgcgtgtg ccagcggttc tcatgccatt
     2041 gggatgggat atttcctgat ccgttcgggt atacaggatt gtatcgtatg tggcggggcg
     2101 caggaagtga atatgtattc ggtcggcagt ttcgacgggc tggcggcttt ctctgtcagg
     2161 gaggacgagc ccggaaaggc atcgcgcccg tttgacaaac accgtgacgg attggttccc
     2221 agtgggggag gggcgaccgt tatcattgaa agttacgagt cggctaaacg gcggggggcg
     2281 aatatcctgg cggaagtggt tggctatggc ttttcttcca acggcgaaca tatttccgtc
     2341 ccgaacgtag acgggccacg ccgctcactc gaaatggcat tgaaagattc gggattggct
     2401 gcccgcgata tacaatatgt aaatgcacat gctacatcca ctccgctggg cgacctgaat
     2461 gaggcgaagg cgattgctgc cgtcttcgga gaaacatccc cgtatgtcac ctctaccaaa
     2521 tcgatgaccg ggcatgagat gtggatggcc ggggcgagcg aagtgatcta ttccatgctg
     2581 atgatgcaga acgggtttat cgctcccaat ctaaacttta cggaacccga cgaggcttct
     2641 gccttgttga acattccggc ggaaacgaaa caactggagt tcgatacgtt cctgtccaac
     2701 tcgtttggct ttgggggaac caactctaca ttaataatca ggaaattcaa atcttaacag
     2761 acaataaaca aacaaatggc aagcacagaa ttaattcaaa agatcaacga gaaactatcg
     2821 gaggagttcg aaatagatat agaactgata caacccgatg ccccgttgat gcagacactc
     2881 gaactcgata gcctcgacct ggtggatatg gtcgtactgg tagagcacaa cttcggtttt
     2941 accctgaaag cgcaggactt tatcgggatt aaaacgttcc aggacttcta cgactttatt
     3001 gactcacgtg tgaatgggtg atagtaacga tacgggctgg aaaggtaaaa cgcgcggagg
     3061 ttctttcggt tacctcttct tcattctctt gataaaaggg ctgggggtaa aggcggcgta
     3121 tgcgtttctt tgtctggtcg tggtctattt tgtaccgttt gcccccaagg cgacccgtgc
     3181 gatctggaaa tatgcgcggc aaaggctggg tcacagccgt ttccgttccg cctgtttcct
     3241 gttgaagaat tattaccggt tgggacaaac cctgatcgat aaagtggcgg tcggtgccgg
     3301 gatggctaaa caatatactt ttgacttcgg cgcgcaatat cccggttttc ttgaagtatt
     3361 gaacgggaac gagggagtag tgatgatcgg tgcccatgtt ggcaactggg agatcggtgc
     3421 ccctttcttc gacgattacg ggaagaagat gaatattgtg atgttcgatg ccgaatatca
     3481 gaagataaaa gaattactgg agaagaatac gaacggaaag aactacaagg ttatccctgt
     3541 aaatgaagat aatctgacac atatattccg gatcagggat gtcctggcca acggggaata
     3601 tgtttgtttc cagggagacc gttatgtgga gggtgcgcag acttttaagg aaacttttct
     3661 cggtgcggaa gcctcttttc cggcgggccc ttttctgctg gcatcccgcc tgggggtacc
     3721 tgtcgtattt tatttcgctg tgcgtgagaa aggaatgcac tataagttta actttgtact
     3781 ggcgcaaccg gagaagcgcg tcaaaggggt ggttcccgga cagggattgc tgaaacagta
     3841 tgtctcagcg ttggaatcgg ttgtgaaaca atatccggaa caatggttta attactatga
     3901 cttctggaaa taacagatag aataagagag aacatggaat tatcatctcc tcaaaaagaa
     3961 atatacgcaa aggatcgttt ttcggctgta caggcgcaac gtctggcaca ggagatcgct
     4021 tttggcccgg tagtcttcca ggtgtcgcgc ctgatggtta aattcgggat cttcggaatg
     4081 ctccgcgaag cacaggacgg tctgacgatg gatgagattg ctgaaaagac aggcctttcc
     4141 cattatgccg tacaggtgtt gttggaatcg tcgttgacga tcggtacgat cctgttgaaa
     4201 gacgggcatt tccatctggg aaaagccgga tggttcctgc tgaacgatga aatggcccgg
     4261 gtcaatatgg atttcaacca cgatgtgaac tatctgggac tgttccggtt ggaagaggct
     4321 ttgctgaatg gcaagcccga aggcctgaag gttttcggta actggccgac catctacgag
     4381 ggcttgtcca gcctgccgga aaaggtgcag gcgagctggt tcggtttcga ccatttctat
     4441 tccgacaact cctttaagca agctctggag attgtttttg ccaatccggt gcgtacgttg
     4501 ctggatgtag gcggcaatac cgggcgttgg gcgatgcaat gcgtggctta ttcgccggag
     4561 gtggaagtga ccattatgga tctgccccag cagttggaga tgatgcgtga acagacccgg
     4621 gaactggaag gggctgcccg tattcatggt catgcagcgg atttgttgga cgacggaaca
     4681 agtttcccgc agccattcga tgccatctgg atgagccagt tcctcgattg tttctcggag
     4741 gagcaggtac tgagcatcct gtcacgtgcc gcccggtcga tggaagcagg cagccgcctg
     4801 tatatcaagg agactttctg ggatcgtcag cgtttcgaga ccgcttctta ttgcctggcg
     4861 cagactagcc tttattttac ggcaatggct aacggcaaca gcaaaatgta ttattccgct
     4921 gatatggccc gcctggtaga aaaggccgga ctggcgatcg aacagataca tgacggcctg
     4981 gggctgggac atagtattat gcaatgtaaa ctgaaataga tatggcatca atctcgttcg
     5041 ataccccttt actgtctggt gacgggctac tggatctgat cccgcagcgt gcgccgatcg
     5101 tgatggttga ccgtttcttc gggatggatg actacgggtc ttataccggg ttggaggtag
     5161 aggactcgaa cctgttttgc caggacggcc aactggatga atgcggcata acggaacata
     5221 tcgcccaatc ggctgccata agggtgggct atctctatcg gtgtgcgggc gaaaagatcc
     5281 cggtcggttt tatcggctcg gtgaataaga tgaacttcta tgctctgccg caggtggggg
     5341 acgaattgca taccacgatc cgggtagagc aggagatttt tgatataacg cttatctcgg
     5401 ccaccgtaca ggtgaatggc actacggttg ccgatggtca gcttaagata tttctaaaga
     5461 aagacgcatg agacggatga aaatacagga agcggcattg accaaccgca cgactttgcg
     5521 ggtcaggttc agcgaggtag attcgatgga agtcgtttgg catggcgaat atgtccgcta
     5581 tatggaagac gggcgggaag ctttcggtcg ccagtacggt atcggctata cggagatacg
     5641 ggatgccggc tatgtagttc cgatcgtcga actgaacatc cagtataagc aatcgctgaa
     5701 atacggtgag tcggctattg tcgagacacg gtatatccgg acggaagcgg ctaagatcct
     5761 tttcgaatat atcatttttc gcgaaagcga cggggcggta gtggctaccg gttccagtac
     5821 gcaggttttc gtggatagtc gcacggggga gctggaattg aataatccgg atttttatca
     5881 agcgtggaga gagaaatgga atatcgggta aacagctata taaccgccgg ctcgatcatc
     5941 agttcgctgg gtttcggcac ggaagaaaat ttctcccgca tccgtgaata ccgttcgggt
     6001 attgcccggg tggaagatac tacccttttc gatacgcctt ttatggcggc acggatagac
     6061 gatacccggc taaaggtact ggcacaggag ttggacggct acactcggat ggagcaactc
     6121 tttatcttgt ccttgtcgga tacgatccgg cagagcggca tcgatcccac tcagtctgac
     6181 tgcgggctga ttatttctac tactaaagga aatatcgata tgttgtccgg gagtcacgat
     6241 ctcccaactc agggagtaga gacttcccag agttgggaag acatccttcc cagtactagg
     6301 aagactgact tcccaggtaa gggaagagct tcttcccaac tttatgaaat ggcgatgtgt
     6361 gttgccggct atttcggttg tgtgaatgaa ccgattgtca tctccaatgc ctgtatctcc
     6421 ggggtatctg cgttgatagt ggcttcccgg ttgatagaag ccgggaaata taaacatata
     6481 ctggtggccg gaggggatct gctgacccgc tttgttgtca ccggctttca atcttttaaa
     6541 tcggtcagtc cggagatctg taaaccctat gataaggcac gtgacggttt gtcattaggg
     6601 gaagcctgcg gatctgtgct ggtgacttcc gaccggggat tggtcgggga ggaacagccg
     6661 gttagtatag caggcggttc catcaccaat gatgccaacc atatttcggg gccttcgcga
     6721 accggcgatg gcctgtatta tgcgatcagc caggcgatgg atgaggcagg cctgcaacag
     6781 gaagccattt cttttgtcaa tgcacatggg acggcaacct tgtataacga tgaaatggaa
     6841 tcgaaagcgc tgcattgggc ggggctcgat cagctgccgc tcaacagtat gaaatcttac
     6901 tgggggcata cgctcggcgc ttccggcatt atcgaagtga ttgcctgtgt ggaggagctt
     6961 cgtagcggtg aggtgttcgg gacattcggg tttgaaacct gcggggttcc ttatccgtta
     7021 tcggtaagtg cggcgcatag gaaggtggcg atggcgcatt gcgtgaaaac ggcgtcaggt
     7081 tttggcgggt gtaatgcggc ggttgtgctg tcgctggaaa ggaagagctt tgacacaccc
     7141 cctgccccct ctcgagaggg gaaaggatac tcctggcgca cggtggtaat agagcggggg
     7201 aagatcgtgc tggatggaga ggtgcttctg gaaacggatt cggcgggagc atttgctacc
     7261 tttatccgtg ctgcttataa gtttttagcg ttggatgacc ggaagtttta taagatggac
     7321 gatctgtgta agctcggata tatcgcggca gcctgtcttt ttgcccggaa cggaggaaaa
     7381 acgggatatg aacccggtga agtcggaatc atatgcgcaa atgcttcttc ctcgatggat
     7441 acggaccgga agcatcaaca tattatcgat acgatgggcg atcaggaagc aagcccggct
     7501 gtgtttgtct ataccttgcc gaatgtggtg ctgggcgaac tctgtatccg ctataagata
     7561 cagggagaga acaccttctt tatcaataac cgttatccgg aatccttcat ccgcgactac
     7621 gccacgctgg tgatgcggaa acagaaactg cgtgcgtgcc tgaccggttg gtgcgagttg
     7681 ctgggggacc ggtatgaagc ccgtttcgac tggctggaac aaacaacgat agctaacgaa
     7741 taattaaaga ataaacgata tggaacaatt aatgcaagaa ttgaaagaag cgctgatcga
     7801 atcgctgaac ctggaagata tcaccccgga tgagatcgat aacgaagcac ctcttttcgg
     7861 tgatgaaggg ctggggctcg actcgatcga cgcgctcgaa atcattttga tcctggaacg
     7921 caactacggc attcgtattg cgaatccggc tgaaggtaaa tctatcttct attctgtgcg
     7981 tacgctggct gactttatca ctgcaaaccg tacgaaatga gagtctgcgt cacaggcatc
     8041 ggttgtgtgt ccggcatcgg tctgaatgtg gaggaacatc ttcgctcgtt ccgtgacggg
     8101 cgggatggac tgggggctgt tacgcttttt cctacacgtc atgaagaacc ggtctccgaa
     8161 gtgaagcgca cgaatgaggc tttgaaagag caactgggta ttcccgtatc cgctgcactg
     8221 tcgcgcacgg ctttgctggg aatgacggca gctttcgagg cgcttgccga ctccgggctg
     8281 gatctctccg atcgggatcg tccccttcgc gtcggccaga tctcttctac ctctaccgga
     8341 ggtatggatc tgacagagtc tttctaccct tccttccggg aaaatccggc acagggtcgg
     8401 ttgcggtatg tcgcttcgca cgatgcgggt gacagtacgg aacggatcgc ttctttcctg
     8461 ggcattaccg gatttcgtac aacggtc
//
