LOCUS       c00083_gnlPro..        13956 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LGLIENAB_83.
ACCESSION   c00083_gnlPro..
VERSION     c00083_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 15:29:30
            Original ID  :: gnl|Prokka|LGLIENAB_83
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13956
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13956
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:3956]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..3956
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13956
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13956
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(2..589)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg83_1"
                     /sec_met_domain="OAD_beta (E-value: 2.3e-70, bitscore:
                     227.6, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLSFLGDNLQLFLTYTGVYNATPGHIIMILVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQVGIYEQGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYIIALQMGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRL"
     CDS             complement(594..1025)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.9; E-value:
                     3e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg83_2"
                     /sec_met_domain="Biotin_lipoyl (E-value: 9.1e-21, bitscore:
                     63.9, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNVYKVHINSVVDDIAEVEVNGTPYNVKMEKPAKKQ
                     MVTLKRPAQAPTTASGEPVVTRPAASTTQGAVKTPLPGVILQIKCNVGDTVKRGQTLLI
                     LEAMKMENNINADRDGKIIEIKVHKGDSVLEGADLVVIG"
     CDS             complement(1048..1932)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg83_3"
                     /sec_met_domain="OAD_gamma (E-value: 2.5e-12, bitscore:
                     37.7, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNKRFGVLLLFILLVSFGAQAQRATSMRINEVLVINEDNFVDDY
                     GKRHGWIELFNTSAGTVNIAGCFLTDDKNNPKKYPIPKGDVLTQIPPHQHTLFWADGEP
                     NRGTFHVNFTLDPSKENYIALYDADGKSLIDEITIPAAQKPDVSYGRIIDGKEEWAQLT
                     KVTPSTNNLTLDSNEKIENFKTNDSLGIGMTITAMAVVFLGLLLLFLIFKQVGKAAIAA
                     SKRNAQKAGAPVNVNTPDEVSGEVFAAIATALYEMSDDNHDIEHTVLTIRKVRRAYSPW
                     SSKIYSLRETPRK"
     CDS             complement(1955..3508)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg83_4"
                     /sec_met_domain="CT_Btheta (E-value: 1.6e-292, bitscore:
                     960.5, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKFLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     ESLAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEEGLQLIRKLLSFLPQNNLEETPLIECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAASEDPAKATA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             complement(3546..3956)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg83_5"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.6e-27, bitscore:
                     86.3, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEITHIEHLGIAVKSIEACLPYYEEILGMKCYNIEEVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALDEAESKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGKK"
     CDS             complement(4157..6571)
                     /locus_tag="ctg83_6"
                     /transl_table=11
                     /translation="MKIRAIAALLFILVSISAFGQKHVKITGYVRDADGSPLELVLVQI
                     KNTLNGAMTNEKGYYSISTSPGDSVAVIFSCLGYNKAERILPSLQQDMRLNVQMNYTSI
                     DLGEVVAVGTRYQTSTLQTMNADRVKLLPDPAGGSIESLVVTFAGVSSSNELSSQYSVR
                     GGSYDENIVYVNGLEVFRPLLIRSGQQEGLSFINPDLTEAVNFAAGGFEARYGDKMSSV
                     LDITYKKPKLFEGSASASLLGANAYVGSSIGKFTQITGVRYKTGRSLLKTMDTDAEYQP
                     DFVDLQSYMTYQLAPKWEVNFLGNLASNTFKFTPHKRETNFGTVENAQRFEVYFPNSRE
                     RDKFQTIFGALTLKHNPNEKTELGLQASAFSSKEIETYDITGEYWLGDATTENDNNQNA
                     LEIARYHEHARNRLSSTIMNVGHYGSSKIKNNTLKWGATVQMEKINDRISEWEKRDSAG
                     YSLPQTGNGVNVISNLYSDNDLSTTRISGYLQDVFKFRTKQGMFTLIGGIRGSYWSYNK
                     EFIFSPRVSLGFIPNFDQNLTFRAATGIYYQSPFYKELRTTVQDAAGNDIIELNKDIKS
                     QRSIHFILGGDYTFRAADRNFKVSADLYYKKLDDLIPYTVDNVKIRYYGENCAKGHAMG
                     IDVKFFGEFVPGTDSWISFSLMKAEQTIRDMVTVPMPNSQGYNVSLFFQDYFPGYKRVK
                     LNLKGVLSGGLPFIAPRTKYEDVKSTFRTPAYKRVDLGFSYQLAGGTDAIMDRGVFRHL
                     KNIWIGVDVFNLFDIKNVSSYYWITNIDNQQYAVPNYLTGRQLNARLIVDF"
     CDS             6718..7272
                     /locus_tag="ctg83_7"
                     /transl_table=11
                     /translation="MESFATLIKNRRSTRKFTDQLLSPEQVEMILKAALMAPASKRKNP
                     WQFVVVEDKEMLKKLAGCKPAGASFLEGCALAVVVMANVMDSDVWVEDASIASIYMQLQ
                     AEDLGLGSCWCQIRNRQTEDDADANVYVRSLLDIPYQLEVLSIIGFGYKDQERKPFDEA
                     HLQWEKIHLGTYKMPEENKEA"
     CDS             7269..8036
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg83_8"
                     /sec_met_domain="F420_oxidored (E-value: 5.1e-09, bitscore:
                     27.1, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIVFIGAGNLATRLSLAMQRVGMQIGQVYSHTEASARQLATRLG
                     CPWTNDLSALQEDGDLYVFSLKDTVLSDVISKVKPNNGMWVHTAGSMPMSVFEGYAQRF
                     GVLYPLQTFSKGSNVNFDVIPVFLEANTDKNADYLKNIASALSENVRFMSSEKRRSLHL
                     AAVFACNFTNHIYTLSYKLLENESIPADVLLPLIDETVSKIHSMPPAAAQTGPAIRYDE
                     NVINKHLAMLDDPDMQAIYRLLSQSIHKEAQNE"
     CDS             8029..8550
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg83_9"
                     /sec_met_domain="HAD_2 (E-value: 2.9e-10, bitscore: 30.8,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSINYDLTKIKAFVFDVDGVLSCDVVSLHPNGDPMRTVHIKDGY
                     ALQLAVKKGYQVGIITGGYTEAVQIRFSRLGIEHIYMRSAVKIHDFNDFLQKTGLTPEE
                     VMYAGDDIPDYDVMKRVGLPVAPADAAPEIKQIAKYISLCKGGEGVARDVIEQTMKAQG
                     HWMSAEAFGW"
     CDS             8569..9159
                     /locus_tag="ctg83_10"
                     /transl_table=11
                     /translation="MLTNLQHYRIVLGSNSPRRKELLAGLDLKFEVEVIPGIDESYPDD
                     LTADEIPAYIARKKAEAYLEKMTDNELLITADTIVVTYGQPDRILGKPADREEAIEMLC
                     HLSGHVHEVITGVCLTTKQKTVSFSVSSAVAFSKLEKDDIIYYVDKYRPYDKAGSYGIQ
                     EWIGYVGVEAINGSFYNVMGLPVQRLYQELKKF"
     CDS             9338..10486
                     /locus_tag="ctg83_11"
                     /transl_table=11
                     /translation="MKNTIILILQIIILGIVSSCEKNEEGITFVDFSDNVFYEWCLSSF
                     DLDGDQELSFRELYLVTEMNIPAQYNGQTIKSLGGIENFAYLEQLTCSDNTELTSLDLS
                     KCSYLKKADCHNCNISSLNLSGCSRLEELYCYSNSLNELNLSDFESLAYLYCDFNVLTS
                     LDFTNNPDLKEISCSGNKLQGDLNLSKCTKLEALLCEKNSIELIDITECTSLKTLICYS
                     NKLTAIDVYSKALEILSCSGNDISWLHVANCENLQELYCSENPSMQILGIKGCVSLKTL
                     ECYSNNLSSLNMSDSKDLTHIDCHNNVLSSITLNSTLITYLDVSQNLLQTLDISLCPAI
                     KCLYFTLNRPLNNGGVSKLRHISFFILKIVVPLFLSMRLFLQ"
     CDS             complement(10464..11621)
                     /locus_tag="ctg83_12"
                     /transl_table=11
                     /translation="MDKIRILLEQVDEAIAQENSTKDTPVEFTPAMLSDIVNELKEVLE
                     HQPVTKDKEQKKVIREKKKQVRELEEHRDKLMEYDNHLDTLGERNSYSKTDPDATFMRM
                     KEDAMRNGQTKPGYNLQIGTQNQFLIDFRLFPNPTDTLTLIPFFHSFEQRYNRLPTVGV
                     ADSGYGSEENYRFMQDNGIEAFVKYNYFHKEQRPRYTPNPFHAESLHYNAEEDYYVCPM
                     GQHMNRIGTRSDKTASGYITESARYKAQRCEGCPLRGSCFKARGNRIIEVNHRLNQYKR
                     LARERLLSKEGFRHRGRRCIEPEAVFGQMKHNMAYKRFRHVGEDKVTMDFAFFAIAFNI
                     KKMCTKLLKAGKRRSTHIIFIFIRPRVAQHTRNIKPYLITEEIVA"
     CDS             complement(11686..12120)
                     /locus_tag="ctg83_13"
                     /transl_table=11
                     /translation="MAKLHFRPYIPNQTVLFPGRIDENIAANDPVRIVNTVVDNLNLDN
                     FKKLYKATGRCPYHPKMMLKVIIYAYMNNIYSCRKIEKLLLRDIHYIWLSGNEHPDFIT
                     INRFRNRVKEEINNVFTQLVLVLVDKGFISLDIEYRRYQD"
     CDS             12134..12241
                     /locus_tag="ctg83_14"
                     /transl_table=11
                     /translation="MPKDTKTLGNNKAWACESLGFVHKKRLCQRFDTTS"
     CDS             12387..13124
                     /locus_tag="ctg83_15"
                     /transl_table=11
                     /translation="MKRMIPLVLLVVFTACNNSFIDEKVSVDEVSELVDSATIAAESVP
                     IEDVIPIMATSTKAEYEAIRLVNNPDSTNLVTVKEYSISTPLTKAGDYTIIKVEYNWIE
                     DMTYVTMQGVTNHEIVLNKTAVTISESVANKWGIDPGYYYVYSWKLTLVYNQSRSHEFV
                     IGDYAGVKPSDENSYGYDLVQTGSNQWTVSTIYYRYEKRSIGPNSDSVIGVYCIPVYSL
                     NEPGVDFNTFKWQYTLQGDYSSK"
     CDS             13486..13803
                     /locus_tag="ctg83_16"
                     /transl_table=11
                     /translation="MYVIVEINGQQFKAEEGKKLFVHHIQNAESGAVVEFDKVLLVDNN
                     GEVKVGVPTVEGAKVVCEVLSPLVKGDKVLIFHKKRRKGYRKLNGHRQQFTEVSIKEIV
                     A"
ORIGIN
        1 gcagtctcat gaacggcggc tggataatag gtaccaacgc catatatgag taggctgaca
       61 ccgcaatagc acccatcagg ttaggggcca gcttggaaga caggaagata gccgtaggac
      121 cgtcagcacc accgataata ccgatagcac cggcctggtt cggttcgaat cccatctgaa
      181 gagcgataat ataagcaccg aagataccga actgggcggc agcaccgatc aacatcagct
      241 ttggattgga aatcaaagcg gagaagtcgg tcatcgcccc gataccgagg aagatcaacg
      301 gcggatacca tccggaggtt accccttgat agaggatgtt aagtacagac ccttgttcgt
      361 agatacctac ctgaagccct gcatctttaa aaggaatgtt accgatcagg ataccgaatc
      421 cgatagggat cagcaacatg ggttcaaatt catatttaat cgcaaggaat ataaagagca
      481 aaccaaccaa tatcataatg atatggcccg gagttgcatt atatactcct gtataggtga
      541 ggaacaactg taggttgtca cccaggaatg ataaaaaact ctcttgcata ctcttatccg
      601 attacgacga gatcagcacc ttccagtacg gagtctccct tatgtacttt aatttcaata
      661 atcttaccgt cgcggtcagc gttgatgttg ttttccatct tcatagcctc gaggataagt
      721 aaagtttgtc ctctcttcac agtgtcgcct acattgcatt tgatttgcag gataacacct
      781 ggaagcggag ttttaacggc gccctgggtt gtagatgctg ccggacgagt aacaaccggt
      841 tcgccgctgg ctgtagtagg agcctgtgcc gggcgtttga gtgtaaccat ttgttttttc
      901 gccggtttct ccatttttac attataagga gtaccgttta cttctacttc agcgatatcg
      961 tcgaccactg aattgatgtg tactttatat acgttaccgt tgatggtata tttaaaactt
     1021 ttcattcttg tttgttttta gagataatca ctttctggga gtttcacgta aactatagat
     1081 cttagaactc catggagaat atgcacggcg aactttgcgg attgtaagca ctgtatgttc
     1141 gatgtcgtga ttgtcatcac tcatttcata caaagctgta gcgattgctg caaaaacttc
     1201 gcccgaaact tcgtccggtg tatttacatt aacaggtgcc cctgctttct gagcattacg
     1261 tttgctggct gcgatagctg cttttccgac ttgtttgaag atcaggaaaa gaaggagcaa
     1321 gcctagaaaa acaacagcca tagctgtaat agtcataccg atacccaaag agtcatttgt
     1381 cttaaagttt tcgatctttt cgttagaatc taacgtcagg ttgtttgtgc tgggagtcac
     1441 ttttgtgagt tgtgcccatt cttcttttcc gtcaataatt ctaccatagc taacatccgg
     1501 tttttgtgca gccggaattg ttatttcgtc gatcaaggat ttaccatcgg cgtcataaag
     1561 tgctatataa ttttcttttg acgggtctaa cgtgaaattg acatgaaaag taccacggtt
     1621 aggttcacca tccgcccaga acagagtgtg ttgatggggg gggatctgag ttagtacgtc
     1681 acccttgggg atcggatatt ttttaggatt gttcttgtcg tctgtcaaga aacaacctgc
     1741 aatattaacc gttccggcag aagtattgaa taattctatc cagccgtgac gtttgccata
     1801 gtcgtcaacg aaattatctt cgttgatgac cagcacttca tttattcgca tggaggttgc
     1861 acgctgtgcc tgtgccccga atgatacgag caggatgaac agcagcaata ctccaaatct
     1921 tttgttagtc atattcattt tcctgtttta agaattatag aggcagattg tcatgtttct
     1981 tagcaggatt gcttaacttt ttcgtctgca attgttgtaa agcacgaatg atacggaaac
     2041 gggtattacg cggttcgatc acatcgtcga tataaccgta ttgagctgcg ttgtacgggt
     2101 ttgcgaatgc tttcttgtat tctgcttctt tttcggctgt tgcttttgca ggatcttcgg
     2161 atgcggcaac ttcttttgcg aagataactt ctacagcacc gctcgggccc ataactgcga
     2221 tttctgctgt cggccatgcg tagttcatat cgccacgcag gtgtttagaa ctcatcacgc
     2281 agtaagcacc accgtaagat ttacgcaatg taacagtgat tttaggcaca gttgcttcgc
     2341 cgtaagcgta aagcaatttg gctccgtgaa ggattacacc attgtattcc tggcctgttc
     2401 ccggaaggaa tcccggtacg tctaccaatg ttaccaaagg aatgttgaaa gcgtcgcaga
     2461 agcgaacgaa gcggcctgcc ttacgggaag cgttgctgtc cagacagcct gccattactt
     2521 tcggctggtt agctacgata ccaacagact ggccgttgaa acgtgcgaaa ccaacaataa
     2581 tatttttagc ataatcagca tgtacttcca ggaattcgtt gttgtcaacg attgtgccga
     2641 ttacttcata catgtcatat gactggttag cgttgtcagg aatgatgtcg ttcaatacat
     2701 cgtccagacg gtcgatcggg tctttgcatt cgatcagcgg agtttcttcc aggttgttct
     2761 gcggaaggaa gctgagcaat ttgcggatca gttgcagacc ttcttcttct gtgtcgacag
     2821 cgaaatgggc aacacccgat ttggttgtgt gtacgcttgc gccacccagt tgttcctgag
     2881 ttacgtcttc accggtaacg gtttttacta ctttcggacc tgtcaggaac atgtagctgg
     2941 taccacgtgt catgatgtta aagtcagtca gcgccggaga ataaactgcg ccacctgcac
     3001 acggaccgaa gatacctgaa atctgaggta caacaccgga tgcaaggata ttacgctgga
     3061 agatttcagc atatcctgcc agagcgttaa cgccttcctg gatacgtgct ccacctgagt
     3121 cgttcaagcc gatgacaggg gcacccatct tcatggcctg atccattacc ttacaaatct
     3181 tcatggccag tgattctgac aaagctcctc cgaatacggt gaagtcctgt gcgaagatgt
     3241 agaccaaacg gccgtcgatc gtaccatatc cggttacgat accatcaccc aggaattttg
     3301 ttttttcaat accgaagtta gtacaacggt gctgaacgaa catatcaaac tcctcgaaac
     3361 taccttcgtc aagcaacatg gcgatacgtt cgcgtgctgt gtacttgcct ttcttgtgct
     3421 gagattcgat tcttttttct ccaccaccta aacgggcttg ttcgcgaaga gcgataagct
     3481 cttttacttt ttcaagttgg ttactcattg tatttctgat ttgttgttag aaatgaactg
     3541 attaattatt ttttacccgg catgcaaagt tcagtcaata cgctgcaagt tgatttcggg
     3601 tgaaggaatg caatgttcag accttctgca ccaccgcggg gagctttgtc gatcagtttg
     3661 acaccttttg attcagcttc gtccaatgca gcctgtacat caggtacagc aaatgcgata
     3721 tggtgaatac cttcgccttt cttttcgatg aatttggcga tagtgctgtc ttcgctggtc
     3781 ggttcaagta attcgatttt tgtttggcct actttaaaga acgcagtctt tactttttgg
     3841 tcagcaactt cttcgatgtt gtagcatttc atgcctaaaa tttcttcata atacggcaga
     3901 caagcttcga tgctttttac tgcaattccc agatgttcaa tatgtgtaat ttccatgtca
     3961 ataagaattt aataattgat aaatgctttt tgttttgatg gcaaaggtac attctttttg
     4021 aagaatcaag aaatatttca ttaataataa tttgccaatt tgccaatatg caaaattgcc
     4081 aatgaaagcc ttgacttctc attggcaaat cctgtttttt atcggcatat tggcaaatta
     4141 tcttattggc atatttttag aaatcgacaa tcagtcgtgc attgagttgt cggcctgtca
     4201 ggtaattcgg tacagcatat tgctggttgt cgatgttggt gatccagtaa taggaactga
     4261 cattttttat atcgaacagg ttaaatacgt ccactccgat ccagatattt ttcaggtgac
     4321 gaaagactcc gcggtccatg atcgcatcgg ttcctccggc cagctggtaa gagaaaccga
     4381 ggtcgacacg tttgtaggcc ggcgtgcgga aagtactctt cacatcttcg tatttcgtgc
     4441 gtggtgcaat aaaaggaagt ccgccggaga ggacgccttt cagattcagt tttacacgtt
     4501 tgtatccggg aaaataatcc tgaaagaata acgatacgtt atatccctgg ctgttgggca
     4561 tgggaacggt taccatgtca cggattgttt gctctgcttt cataagcgag aagctgatcc
     4621 atgaatcggt tccgggtaca aattcaccga agaatttaac atcgataccc attgcatggc
     4681 ctttggcaca gttctctccg tagtaccgga tctttacgtt gtcgacggtg taaggaatca
     4741 ggtcgtccag tttcttgtaa tagaggtcgg cactgacttt aaagttacgg tcggctgccc
     4801 ggaacgtata atcgccaccg agaatgaaat ggatggaacg ttgcgatttg atatccttgt
     4861 tcagttcgat aatatcattg cctgcggcat cctgcacggt ggttcgtaat tctttataga
     4921 acggtgactg gtagtagata cctgtcgctg cacgaaaggt cagattctga tcgaaattag
     4981 ggataaaacc taaagaaacg cgtgggctga aaatgaattc tttgttatag ctccagtagc
     5041 ttccgcggat accgccgatg agtgtgaaca taccttgctt ggtacggaac ttgaaaacgt
     5101 cctgcaaata tcccgatatc cgggtagtcg acaaatcatt gtccgaataa agattggaga
     5161 tcacgtttac cccgttccct gtttgaggaa gtgagtaacc tgccgagtcg cgtttttccc
     5221 attcgctgat gcggtcgttt atcttttcca tctgtacggt ggctccccat ttcagcgtgt
     5281 tgtttttgat cttgctactg ccgtaatgtc ccacattcat gatggttgaa cttaaacggt
     5341 tgcgggcatg ctcatggtag cgggctattt caagggcatt ctggttattg tcgttttctg
     5401 ttgtagcatc gcccagccag tattcgccgg tgatgtcata ggtttctatt tccttgctgg
     5461 agaaagcgga tgcctggagg cccagttctg ttttctcgtt cggattgtgt ttcaaggtca
     5521 gtgcgccgaa gattgtctgg aacttatccc gctcgcggct gttggggaaa tacacttcaa
     5581 accgttgggc gttttctacc gtaccgaagt ttgtctcccg tttatgcggg gtgaatttga
     5641 acgtgttgga cgccaggttc cccagaaagt ttacttccca tttcggagct aactgataag
     5701 tcatgtatga ttgcagatcg acgaaatccg gctggtattc ggcgtccgta tccattgttt
     5761 ttagtagcga acgtcctgtc ttataacgaa caccggttat ttgtgtgaac ttgccgatgg
     5821 aactgcccac ataggcgttt gctcccagta agctggcgga ggccgatcct tcaaataact
     5881 tgggtttttt ataggtgatg tcaagaacag agctcatttt atctccatac cgtgcttcaa
     5941 atcctccggc tgcgaagttg accgcttcgg tcaggtcggg attgataaag ctcagacctt
     6001 cctgctggcc ggaacggatc agtaacgggc ggaatacttc caggccgttt acatatacta
     6061 tgttttcatc gtaactaccg ccgcgaaccg aatactggga acttaattcg ttgctggatg
     6121 aaactccggc aaaagtgacc acgagacttt cgatgcttcc gccggcaggg tcggggagga
     6181 gcttgacacg gtctgcattc atggtttgaa gggtactggt ttggtaacgg gtacctacag
     6241 caacaacttc tcccaggtcg atacttgtgt agttcatctg tacattcagc cgcatgtcct
     6301 gttgcaaact gggtagaata cgttctgcct tattatatcc cagacaagag aaaataaccg
     6361 ctacggaatc gcccggcgac gtggagatcg aatagtaacc cttttcattg gtcattgccc
     6421 cgttcagcgt attctttatc tgaacaagca caagttcaag cggactaccg tcggcatccc
     6481 gaacatatcc cgtgatttta acatgctttt gtccaaaagc gctgattgaa actaatataa
     6541 atagcagtgc agctatcgca cgaatcttca taattaataa tgttatagct ttactaacgc
     6601 gaaaaatgaa ggaagcgtat attcagcgtg taaaaaaata tttatctttg tcctgttcag
     6661 aaatatcttc cttacagaat gaagatgatt aattaacagc tacaaaataa gataaaaatg
     6721 gagagttttg caacactgat aaagaataga agaagcacgc gtaagtttac cgaccagttg
     6781 ctttcacctg aacaagtcga aatgatttta aaggcagctt tgatggcacc cgcttccaag
     6841 cgtaaaaatc cctggcagtt cgttgtggtg gaagataagg aaatgttgaa aaaactggct
     6901 ggttgtaagc cggccggagc ttcgtttctt gaaggttgtg cactggctgt tgtggtaatg
     6961 gcgaatgtaa tggatagcga tgtctgggtg gaagacgcct cgatcgcttc tatctatatg
     7021 caactccagg cggaagatct gggtctgggc agctgttggt gccagatacg taaccggcag
     7081 acggaagatg atgcagacgc caatgtgtat gtccgtagcc tgctggatat tccttatcag
     7141 ctggaggtgc tctcgattat cggtttcggt tataaggatc aggaacgcaa accgtttgac
     7201 gaagctcatt tgcaatggga aaagattcac ctgggcactt ataaaatgcc ggaagaaaac
     7261 aaggaagcat gaaaatagtt tttatcggag ccggaaatct ggcgacacgt ttgtcgctcg
     7321 ccatgcaacg ggttggtatg cagattggtc aggtgtacag ccatacagag gcgagtgccc
     7381 gtcagttggc aacacgactg gggtgtccgt ggacgaatga tttatccgct ttgcaggaag
     7441 atggcgatct gtatgtcttt tcactgaagg atactgtctt gtcggatgta atatcgaagg
     7501 tcaaaccgaa taacggtatg tgggtccata cggcaggaag tatgccgatg agcgtatttg
     7561 aaggatatgc ccaacgtttc ggagttcttt atcctttgca gacattcagt aaggggagta
     7621 atgtgaattt tgatgtgatt cctgtttttc tggaagcaaa cacggataag aatgcggatt
     7681 atctgaagaa tatagccagc gctctttctg agaatgttcg tttcatgtct tcggaaaaac
     7741 gccggagttt gcatctggcg gctgtctttg cctgtaattt taccaatcat atttatacat
     7801 tatcttataa gttactggaa aacgaatcca ttccggcaga tgtccttttg ccgcttatcg
     7861 atgagacagt atcgaaaata cattccatgc cgcctgctgc ggctcagacc gggccggcaa
     7921 tccggtatga tgaaaatgtg atcaataaac acctggctat gctggacgat ccggatatgc
     7981 aagcgatcta ccggcttctt agccaaagta tacataagga ggcccaaaat gagtagtatc
     8041 aattatgacc tgacaaagat aaaagcattt gtgtttgacg tagacggtgt gctgtcgtgc
     8101 gatgtggtat cacttcatcc caacggtgat ccgatgcgca cagtccacat caaagacggt
     8161 tatgccttgc aactggctgt aaagaaaggt taccaggtcg ggattattac cggtggctat
     8221 acggaggctg tgcaaatccg tttttcccgc ttgggtatcg aacatatata tatgcggagt
     8281 gccgtaaaga tacacgattt caatgatttc ctgcaaaaga cgggattgac gcctgaagaa
     8341 gtcatgtatg ccggagacga tatccccgac tatgatgtga tgaagcgggt aggcttgccg
     8401 gttgctccgg cggatgcagc cccggaaatc aagcaaatag cgaaatatat ctccttatgc
     8461 aaagggggtg agggtgttgc ccgcgatgtg atagaacaaa caatgaaagc acaaggccat
     8521 tggatgagcg cagaagcgtt cggatggtaa taacaatgaa aaataattat gctgactaac
     8581 ctacaacatt accgaatcgt gctgggatct aactcacccc ggcgaaaaga attattggcc
     8641 ggacttgacc tcaaattcga ggtcgaagta attcccggta tcgacgaatc atatcctgat
     8701 gacttgacgg cagacgagat acctgcttat atcgcccgta aaaaggcaga agcgtatctg
     8761 gaaaaaatga ctgataacga attgctcatt acggctgaca caatcgttgt cacttatggg
     8821 caaccggatc gtatcctggg caaaccggcc gaccgtgagg aagcaatcga gatgctttgc
     8881 cacctgtcgg gccatgtaca tgaagtcatc accggcgttt gcctgacgac taaacagaaa
     8941 acggtttctt tttccgtctc ttcggcagtc gccttttcca aactggaaaa ggatgacatt
     9001 atctattatg tagataaata tcgtccgtat gataaagccg gcagttacgg gatacaggaa
     9061 tggatcggtt acgtcggggt agaagctatc aatggctcat tctataatgt aatggggttg
     9121 ccggtgcaac ggttgtatca ggaattgaaa aagttttaag cgttgtttcc ttgtgaaaat
     9181 atttagtgaa cgatggggct gatttatggg catggccgat aaattaagct gcctcatcga
     9241 ctgatatgtc ccgttggcgg attttatttt gattatctga aaacatatga gatatttgtt
     9301 cgtattgaaa tatgaacaat attaaatttc agataaaatg aaaaacacaa ttatccttat
     9361 tctacagata attattttag gaatagtatc ttcgtgtgag aagaatgaag aaggcataac
     9421 atttgttgat ttttctgaca atgttttcta tgaatggtgt cttagctctt ttgacttgga
     9481 cggagatcaa gaattatcgt ttcgggaact ttatctcgta acagaaatga atattcctgc
     9541 tcagtataac ggacaaacaa taaaatcgtt aggtgggatt gaaaattttg catacctgga
     9601 acaattaaca tgtagtgata atacggaatt gacttcatta gatctcagta agtgttctta
     9661 tttaaaaaaa gcagattgcc ataattgtaa tatttcttca cttaatctga gtggatgcag
     9721 tcgactggaa gagttatatt gttatagtaa ttctttgaat gaactcaatc tttccgattt
     9781 tgaaagttta gcgtatttgt attgtgattt caacgtactg acatctttgg actttacaaa
     9841 caatcccgat ttgaaagaaa tttcttgttc aggaaataaa ttgcaaggag atcttaattt
     9901 aagtaaatgt actaaactgg aagctttgct ttgtgaaaag aattctattg aattgataga
     9961 tataacagaa tgtacatcgt taaaaacatt gatttgttat tcaaataaac ttaccgctat
    10021 cgatgtttat tcaaaggctt tagagatatt gtcctgttcc ggaaatgata tatcctggtt
    10081 gcatgttgca aactgtgaga atttacagga attgtattgt tctgaaaatc catcaatgca
    10141 aatcctagga attaaaggct gtgtgtcctt gaaaacattg gaatgctatt caaataattt
    10201 gtcatcgttg aatatgtctg attccaaaga tcttacacat attgattgtc ataataatgt
    10261 tttatcttcc attactttaa actctactct gatcacttat ttagatgtat cacaaaatct
    10321 gcttcaaacg ttggatattt cattatgtcc cgccatcaaa tgtctatatt ttactttgaa
    10381 tcgccctttg aataatgggg gtgtgtcaaa actaaggcac atctcctttt ttatcttaaa
    10441 aatagtcgtt cctctttttt tgtctatgcg actatttctt cagtaattag gtaaggctta
    10501 atattcctcg tatgttgagc cacacgtggt ctgataaaga taaatataat gtgtgtactc
    10561 cttctctttc ctgcttttaa tagttttgta cacatctttt tgatattaaa agctatagca
    10621 aagaaggcaa agtccattgt aaccttgtct tctcccacat gccggaacct tttgtatgcc
    10681 atgttgtgtt tcatttgtcc aaaaactgct tccggttcta tacatcgcct tcccctatgc
    10741 ctgaagcctt ctttcgagag taacctttcc cgtgccagcc gtttgtattg gtttaatcgg
    10801 tggttgactt ctataatacg gttcccccgg gctttaaagc aactaccacg taaaggacac
    10861 ccttcacatc tttgtgcttt ataccgggca ctttcggtga tgtatccgct agctgttttg
    10921 tcactcctgg ttcctatacg gttcatgtgc tgccccatag gacaaacgta ataatcctct
    10981 tccgcattgt aatggagact ctccgcatgg aatggattgg gggtataacg gggacgctgt
    11041 tctttatgga agtagttgta cttgacaaag gcttctatcc cattatcttg catgaatcgg
    11101 taattttctt ccgagccgta accggaatct gccacaccga cagtcggtaa gcggttatag
    11161 cgttgctcaa aggagtggaa gaaaggtatg agggtcagtg tatcggttgg attgggaaac
    11221 agtcggaagt ctatgaggaa ttggttctgg gtacctattt gcagattata tccgggcttg
    11281 gtctgcccgt ttctcatggc gtcttctttc atgcgcatga aggtggcatc aggatcggtc
    11341 ttggaatagg agttgcgttc tccaagagtg tcaagatggt tgtcgtattc catcaacttg
    11401 tcacggtgtt cctcaagttc ccggacttgt ttcttctttt cccggatgac tttcttttgt
    11461 tccttgtcct ttgttacagg ctggtgttcc agcacctctt taagttcatt cactatatct
    11521 gagagcatgg cgggagtgaa ctctacgggt gtgtctttgg tggagttctc ttgggctatg
    11581 gcttcatcca cctgctccag gagaatgcgg atcttatcca tcagctttgt acggttcttt
    11641 tcgactgtct tgcgccagac aaaagtatat ttgttggctc tggactcaat cttggtaccg
    11701 tcgatattct atgtcaaggc tgatgaaacc tttgtcgaca aggacaagaa ccaactgcgt
    11761 gaatacatta tttatctctt cttttacacg attacggaaa cggttgatgg taataaaatc
    11821 cggatgttca ttaccggaaa gccagatata atgaatgtca cgtaggagaa gcttctctat
    11881 tttgcggcac gaatagatat tgttcatgta ggcgtagata atcaccttaa gcatcatttt
    11941 aggatgataa ggacaacgac cggttgcttt ataaagcttc ttgaaattgt caagattgag
    12001 attatcaaca actgtattaa ctatgcgaac cggatcattc gctgctatgt tttcatcaat
    12061 tcttccggga aaaagaactg tttggttggg aatgtaagga cgaaaatgta actttgccat
    12121 aatgaaaaac tttatgccta aagatacaaa aactttgggt aataacaaag cctgggcttg
    12181 tgaaagtctg ggctttgtgc ataaaaaaag gttgtgccag cgttttgaca caacctcgta
    12241 acaaatttgc gtaatgtaaa tggggaagct atagatttag gtggcggaga taaatctgta
    12301 ttacaatata aataatgatt tatagatatt caatatcaat ttgcttttgt aaatagtatt
    12361 agtattgtta ttaattagaa tgtattatga aaagaatgat tcccttagtg ttattagttg
    12421 tgtttacagc ttgtaacaat tcatttattg atgaaaaagt atcagttgat gaagtttctg
    12481 aacttgttga ttctgcaaca attgctgccg aatcagttcc tattgaagat gttatcccta
    12541 ttatggcaac atcgacaaaa gctgaatatg aagcgattcg cttagttaat aatccagatt
    12601 cgactaattt agttactgtc aaagaatata gtataagtac acctcttaca aaagctggtg
    12661 actatactat tatcaaggtt gagtataatt ggattgagga tatgacttat gttaccatgc
    12721 aaggtgttac taatcatgaa attgtattaa acaaaacagc tgttaccatc agtgaaagtg
    12781 ttgcaaataa atggggtatt gatccgggat attattatgt gtattcttgg aaactgactt
    12841 tggtttacaa tcaatcaaga tcacatgagt ttgtaatagg tgattatgca ggagtcaaac
    12901 ctagtgatga aaattcttat ggttatgatt tagtgcaaac gggaagtaat caatggactg
    12961 tttctactat atattatcgt tacgaaaagc gtagtattgg tccaaattca gatagtgtta
    13021 ttggtgtcta ttgtattcct gtatattcat tgaatgagcc gggggtagat tttaatacct
    13081 tcaaatggca atatactctt caaggagatt attcatcaaa gtgaatgttt ttaaggaaaa
    13141 agaaggttga ataaagttct aaagtaaaca atttgatata atagtcttat tgtttacttt
    13201 aggacttatt gatattgttg tgtatttata atactttggt agtagcttaa cgtaaaagag
    13261 tgtttaaaag gtatgaaacc ataggtctgt tgttgcgtat aatttgtatt tataataaag
    13321 tggttttctt cttagatagg aaataatcga aaaaaaacga atatttcttg cataatatat
    13381 tcggaaacag tacttttgca gtctgaaatt ccgcagaggg taaacaagtg atatggaata
    13441 tgtatccacc cccgggacat aacctgttta aatataaaaa gacagatgta cgtaatcgta
    13501 gaaattaacg gacaacagtt caaagctgaa gaaggtaaga agttgttcgt tcatcacatt
    13561 cagaacgcag aaagcggtgc tgttgttgag tttgacaaag tgttgttggt tgacaacaac
    13621 ggagaagtta aagtaggtgt tcctacagta gaaggcgcaa aggtagtatg tgaagtactg
    13681 tctccgctgg taaaaggtga taaagtgctg atcttccaca agaagagaag aaaaggttat
    13741 cgtaaactga acggtcaccg tcagcagttc actgaagtga gtattaaaga aattgttgct
    13801 taacgtttaa aggagaaaag aagaaatggc acataagaaa ggtgtgggta gttcaaagaa
    13861 cggccgtgaa tcacaaagta aaagattagg tgttaagctt tttggtggtg aagttgctaa
    13921 agctggtaac attttggttc gccagagagg tacagt
//
