LOCUS       gnlProkkaKCKPCBEF_80   10595 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KCKPCBEF_80.
ACCESSION   gnlProkkaKCKPCBEF_80
VERSION     gnlProkkaKCKPCBEF_80
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 07:25:53
            Original ID  :: gnl|Prokka|KCKPCBEF_80
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10595
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10595
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1281:5595]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1282..5595
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10595
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10595
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             70..1218
                     /locus_tag="ctg80_1"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLESYLDEESSPWWDYLIGFPGMVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQLEYYAAQRKYADYVDAHDNVVL
                     QSVRTEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             1282..2001
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.3e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_2"
                     /sec_met_domain="NTP_transf_3 (E-value: 6.4e-17, bitscore:
                     52.2, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2022..3323
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_3"
                     /sec_met_domain="CTP_transf_like (E-value: 2.1e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9e-122, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.1e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             3340..4464
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_4"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4474..5595
                     /NRPS_PKS="Domain: Aminotran_5 (30-335). E-value: 6.5e-34.
                     Score: 109.2. Matches aSDomain:
                     nrpspksdomains_ctg80_5_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_5"
                     /sec_met_domain="Aminotran_5 (E-value: 3.1e-31, bitscore:
                     98.4, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKDALNHYNVTLPMS"
     aSDomain        4564..5478
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg80_5_Aminotran_5.1"
                     /evalue="6.50E-34"
                     /label="ctg80_5_Aminotran_5.1"
                     /locus_tag="ctg80_5"
                     /protein_end="335"
                     /protein_start="30"
                     /score="109.2"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKIST"
     CDS             5592..6068
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.8;
                     E-value: 2.3e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg80_6"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGSVVTKDVPSGVLVAGVPAVVKKQLLME"
     CDS             6137..6958
                     /locus_tag="ctg80_7"
                     /transl_table=11
                     /translation="MKDKTCHIITDDNIKEIELSILKYIDLQCKKYNLRYYLGYGTLLG
                     AVRHQGFIPWDDDIDIWMPREDYDKFISLENSLENSEFKILSPLSNSDYYYGFAKLVSR
                     NTELQEIGFLPIKDYGVYVDIFPLDNIATEHPFLHFIAKYIIMARIASCNIKPWLNLTH
                     KKKAILFRFIGIIGTLLGFRRTAKLTDKIAKIDKGKTNKRVGVFVESIGEHNIFATEYF
                     ASTIQLKFEGIYFNAPKEYRKCLTQLYGDYMQLPPENRRISGHSFKACYRL"
     CDS             6943..7701
                     /locus_tag="ctg80_8"
                     /transl_table=11
                     /translation="MLQIMKLTTYVLNLLKDKERKEYMQYVLSDYPNLDIQYVNAINGK
                     NLSLDEILNQFDNNKAYKRYGRECDLGEIGCSLSHRLAFDLLMNSESNYALILEDDIVI
                     GDGFSSVLEKLLPLIDIDAPCVILLSGGVSYYKKRYYNTLCLGVVYMGDYAHSYLINKA
                     AAKLILDDKKAYIFADDWDYIRNRGVNVLVILPHLVDQRRDGSFVSNVWQDNHHIVKVK
                     LSLIRLCNYILSRIIDKILKRMGNYENKTL"
     CDS             7703..9238
                     /locus_tag="ctg80_9"
                     /transl_table=11
                     /translation="MVESRSKKGIANIKCSLFFYIINLFLNIISRKVFIDYLGIEVLGL
                     NTTVTNLLSFLNLAELGIGNAIAFTLYKPLFLKDFQVIREIVSVQAWLYRRIAYFISIG
                     ALGLMLLFPVIFKKIDLPLWYAYATFIVLLIASLLSYFVNYKQILLSADQKEYKITLCV
                     QGIKSLKTITQVVVILYLINGYVYWLTLELVGVLVSALLLNKIVNKEYPWLFVKVSDGK
                     NLRNKYPEIIVKTKQFFFHRISSFVLNQTSPLIIYAFASLTMVAIYGNYMLIVFGGIAL
                     VNAFFNGFNAGVGNLVAEGDKKKIKSFFWEITSFRIWIAAIICVCFFKLCHPFISLWVG
                     KEYVLDEMTFIVLTIYVFISLTRVNEAFLFAYGLYQDIWAPIIEAILNLGLSVLLGFIW
                     GLTGIISGVVISLVVIVCIWKPYFLFKMGFKDNILEYVSRYIKYYMMIALSFILSHLIL
                     NTMFIDFQSSYWKLFEYACTVGSCYAILSFLFFYLFDNGMRQFTRRLLNIFLK"
     CDS             9308..10321
                     /locus_tag="ctg80_10"
                     /transl_table=11
                     /translation="MSFYIFIFVVLLYFSFRKYNKYIYWGTILLLSLIAGLRSETIGVD
                     THAYKDIFIWISNEVLYPIEPAWYFLNKLIAWVGGSFNFLLWITSLLTLIPIGVVSLRC
                     SSNPQMSLFFYYGLYAYINSFNGMRQFVAISFVLLAYSYITQKKNFFLYLLIAFIFHYS
                     AIFSFIAILVDKVSLTKRRVIGGIFSSFFVGMFFNDSMFLVLAGPYAGYLESSEGYRDN
                     FLLAAIMAILMSCLYMCTFFTLRREYKQNLWTKMFFVGIIILNITMRLELGARIILYFT
                     LCQIIFYPMYFRHNIVKNKRMVVLSILLYTSLVFMKILILGNQGEYSVYPYKTILW"
ORIGIN
        1 cttccttcag ttctttgggt atgatgattg cttctattgc taatttgata aagaaataaa
       61 tgacctatta tgattgaaaa gcaatcttat caagaaccgt tttctgaagt ggataaaagg
      121 aaagatgatg aaatggaaat agacttgatg gctatttttt ataagattat tactgttcgt
      181 ggagtactat gcaaagctgc tggagtggga gtaataattg ctatagtggt ggcattgagc
      241 attcccaagc aatatacagt aaaggttacc ctttctcctg aaatgggtaa tgcgaaggga
      301 agtaatggtt tagccggact tgctgcctcg tttttgggag atggggctct aataggggaa
      361 agcacagatg ccttgaacgc ttctctttca gcagatattg tttcttcaac tcctttttta
      421 ttggaacttt tagaaatgga agtctccgtt tctaaaaagg atgataaaat gactttggag
      481 tcttatctcg atgaagagtc atctccctgg tgggattatc ttataggttt tccgggcatg
      541 gtaatagggg gagttaaatc attattcgga gaagatacgg ttcctgccag tggagggcgg
      601 caaggaacta ttgaattgac gaaagaagta aatgagaaga ttaattttct taaaaagaag
      661 attagtgcat ccattgataa gaaaaccgcc ataacgagca ttactgtcac cttacaaaat
      721 ccgcagatca ctgcggttat agcagattct gtcgttcata aattacagga atatattatt
      781 gggtatcgaa cttcaaaagt aaaagaagac tgtgcgtatt tggaacggtt gtttaaagaa
      841 cgtcagctgg aatattatgc tgctcaaaga aaatatgcgg attatgtaga cgcccatgat
      901 aatgtggttc ttcaaagtgt acgtactgag caggagcgtt tacagaacga catgagtctg
      961 gcttatcaga tatatagtca ggttgctaat cagttgcagg tatccagagc caaagtacag
     1021 gaggaaaagc cggtctttgc agtagttgag cctgccgttg tacctttgaa accttcaggt
     1081 atgggactca aaatttatat tttattattt gtgttcctgt ccgtatctgg tactctcgtg
     1141 tgggtgcttt ttggcaaaag tctgctggct agcttgagaa aagaactgaa aaataaggag
     1201 atagaacagg ataaatgatg ctaaaacgtc gtttacaaca ttcttacatc aattaaattc
     1261 acttactata ttattaaacg aatgatacgt acagctatga taatggctgc gggcatggga
     1321 acccgttttg gccaatatac agaattgata cctaaagggt tcgtcaaagt gggaggtatt
     1381 ccaatgatag ttcgttctat tgatactttg ttatcatgtg gcattgagcg aattgtaatc
     1441 ggtacaggat ataaacaaga agtttatgaa gaattgaaga cagactatcc tatgcttgaa
     1501 acctgtttta gtcctcgtta tgctgaaaca aatagtatgt atactttata taatacgcgg
     1561 gagattctgg gcaatgatga ttttttattg ttagagtcag atttgatttt tgagaaacaa
     1621 gccataatga gcttattgga gtgtcctgcg gcagatgcaa tgctaataac tccagtgaca
     1681 aagtttcaag atcagtatta tgtggaacat gatgataatt ttcgcctttc ttcatgttct
     1741 gtcaataaga ataaactaaa cgctaaaggc gaattggtcg gcatccataa actatccggt
     1801 tccttttaca aaataatgtg tgctgattat gcgagtattg ttgatgaaca acccaatttg
     1861 ggatatgagt atgaattact acgaatatct tgttctcaat ctcctgttta tgtgcataaa
     1921 gtagaagggc tgaaatggta tgaaatcgat gacatatcag atttggaata tgcagagaaa
     1981 tatattgttc cgtattgtta attaaaataa tatatcaaat tatgagtaag acagtttata
     2041 ttgggatgac tgcggatatt atgcatccag gacttatccg cattattaat gaggctacta
     2101 aatacggtga tgttataatt ggtcttctta cagataaagc tattgcggag cataaacgcc
     2161 ttccttatct gacctatgaa caacgaaaag aggtagttca gaatattaaa ggcgtatgta
     2221 aagttgttcc tcaagaagaa tggagctatg ttgagaatct caaacgcatt aaacctgact
     2281 atataattca tggtgacgac tggaaaaccg ggcctttacg tgaagaacgt gtgcgcgtat
     2341 ttgaagtgat gaatgaacag ggaggaaagg ttatcgaaat tccatatact ttgggaatta
     2401 attcatcttc tttggataaa gatattaagg ctataggtac aacccctgat gtacgtttaa
     2461 aatcacttcg tcgtttgata aatgccaaac ccgtagttcg tattttggaa gctcatgatg
     2521 gactatgtgg cttgataatt gaaaatcagg aaatattaaa aggggataag agggaagtat
     2581 ttgacggaat gtggtctagt agccttacgg attcaaccag taaaggtaaa cctgatattg
     2641 aggcggttga tttaactacc cgattgcaag atttgaataa tattctggag tgtactacta
     2701 aacctattat ttttgatgga gatacaggtg gtaaaattga acatttcgta tttacagtac
     2761 gcactttaga acgtcatgga atctcagcta taataattga agataaagtt ggattaaaaa
     2821 agaattcatt gtttggtacg gatgttattc aaactcaaga tacaatcgaa ggtttctgta
     2881 ataagatcaa agcaggaaag gcatctcaga ttactgatga ttttatgatt atcgctcgta
     2941 ttgagagcct tatagcggga aagccggtaa gtgatgcttt agagagagct tttgcatatg
     3001 tccaagcggg agcggacggt attatgatac atagcaaaaa taagtcgggt gaagatataa
     3061 aagaattttg tttggcgttt cgaaaacagt atgctcatgt acctatcgtg gttgtgccta
     3121 ctacatatga tcatatttat gagtctgaat tgtgtgattg gggtgtgaat ataattattt
     3181 atgctaatca tatgcttcgt gccgcttatc ctgctatgat gaatgtcgca aagacaatat
     3241 tagagaatga acgtgcttta gaggtgcgcg aactgtgtat gcccataaag gaaatattgg
     3301 aactgattcc gggtactaaa taaaaagagg aatatcatta tgttaagcgt agaaaaagtt
     3361 tatgaaacgt ttctgagtca tgacgttgat ttttttacag gagttccaga ctcattacta
     3421 aagaatattt gtgcctatat cacagaccat acttcacgtg agaaacatat catagctgct
     3481 aatgaaggtg cggctgtagg aattgcttca ggttattata tggcatcagg taaggttcct
     3541 gtggtttata tgcaaaattc cggcttgggt aatactgtta atcctctgct gtctcttgca
     3601 gatgaacaag tatacagttt tccaatgctt ttgatgattg gctggcgtgg tgaaccggga
     3661 acaaaagatg aacctcagca taaaaaacag ggtgaggtaa ctttagattt gttgaaagca
     3721 atgcggattc cttatataat tcttgattca aatgagaatg atgcatttat tcagctccat
     3781 gatatcatac aatcagcaaa aactaagaat attcctcatg caataattat tcggaaagat
     3841 gtttttggca aatataaact tcaaaaagaa ttcggatgta attatccttt atctcgtgag
     3901 gatgctttgc aaatagttgt ggattatctg cctgaaaatt cagtggtcgt ttctactact
     3961 ggcaagcttt ctcgtgagtt atttgaatat cgagaaatga aagagcaagg tcatgaacat
     4021 gattttctca cggtaggctc tatgggacat agttcatcaa tctctttggg tattgctata
     4081 gcaaagcaag atagacctgt ttattgcttg gatggtgatg gagcatttat tatgcattta
     4141 ggggcaatta gtaacattgg cgatttatct cctaaaaact attatcatat tttgtttaac
     4201 aatggtgctc acgagtctgt aggaggacag cctactttag gatttagttt agatattccg
     4261 gctattgtcc gggggagcgg atataagcat acttatactg tttgtacaaa agttgaaatt
     4321 gaagaagcaa tgaagcagct tccaaagtta tgtggtcctg ttttgttgga aataaaggtt
     4381 aaaatagatt ctcgggagaa tttgggacgt cccacgacta ctcctataga gaataaggag
     4441 cattttatgg attttttaaa ataaatatat tcgatgaaaa tagaaagaaa aatattatta
     4501 aatcctgggc ctgccactac tactgacagt gtaaaaatgg cacaagttgt tccggatatt
     4561 tgtcctcgcg agaaagaatt cgcaggtatg atgaaacaac ttcgggacga tttggtcaga
     4621 gttgctcatg ggaatttgga aaaacatacc gctgtattat tttgtggctc aggaaccatc
     4681 aatattgata tatgtctaaa ttctcttctt cctgaagaca aaagggtgct tatagtgaat
     4741 aatggggcat atagtacccg tgctgtagaa gtgtgtcaat attatggttt gcctcatatt
     4801 aatttggaat tttccgttta tgaacgtcct gatttatcgg tagtggaaaa tgtgttacaa
     4861 gaaaatcctg atatagctat ggtttatact actcatcacg agacgggtac aggaattctg
     4921 aaccctattc gcgagatggg cgctatagct cataaatatc aggctaaatt tgtcgtcgat
     4981 actacttctt ctttgggcat gattcctttt gatatagaga aagataatgt ggatttttgt
     5041 atggcatctg ctcaaaaagg acttcaagcg atgacaggtc tttcttttat tataggcaat
     5101 gaggaacaga ttaagttttc aaaaaaatat cccaagcgtt cttactattg taatctttat
     5161 ttgcagtatg agaattttga gagaacaggt gaaatgcatt ttactccacc ggtacaaact
     5221 atttacgcca ctcgtcaggc attaaatgaa tattttgaag tgggcgaaga agctaagttt
     5281 gctcgtcaca aaagagtttt tgaggctatt cattcaggta taaatgaaat tggtcttaaa
     5341 agtgtaataa agcgtgaatg gcagtcagga ctggttgtct cagttcaata cccagaagat
     5401 cccaactggg attttgagaa aatacatgat tattgttatg agcgtggatt tacgatttat
     5461 ccaggtaaga tatcaactga ggatactttt agaatctgtg ctttaggaga gatagaagta
     5521 gatgatattg agaacttctt taaagtacta aaagatgcat taaatcatta taacgtcaca
     5581 ttaccgatgt catgattgca gaaatattat tgaagattcg tcatttttat ttttcccttc
     5641 gtggtataca cttccatccg gaaagtgtta tttctggagt gcctattcgt agctttcgct
     5701 tagtaggcaa atatagcaat atctacttag gtaaaaatgc tgaaatacgt tcaggctgtt
     5761 atctgattgc tcgtgataaa atcattattg gagaaaactc aacactcgcc tatggaacga
     5821 ctatattgac aactgctgat cctaatggac cgtataatgc attagcagtt ctttatcctt
     5881 ataaaaaggc accggtagtt ataggagata atgtttggat tggggctaat gttaccatcc
     5941 ttcctggagt aactattggt gattacgttg tagtagcagc tggatctgtt gtaacaaaag
     6001 atgttccttc aggggtattg gttgctggtg taccagctgt tgtgaaaaaa cagcttttga
     6061 tggaataaga ataattgttt tattcttatt gtcagacaat atcattacat aagaagtata
     6121 atttaatgcc tcaataatga aagataaaac ttgtcatata ataacagatg ataatataaa
     6181 agaaatagaa ttatctatat tgaaatatat tgatttacaa tgtaaaaagt acaatctaag
     6241 gtattatttg ggatatggta ctttattggg agcagtgcgt catcaaggtt tcattccttg
     6301 ggatgacgac attgatatct ggatgccacg ggaggattat gacaaattta taagtttaga
     6361 aaattcattg gaaaactcag agtttaagat tttatctcct ttgagcaatt cagattatta
     6421 ttatggattt gctaaactag tatcaagaaa tacagaactt caggaaatag gatttcttcc
     6481 tattaaggat tatggtgtat atgtggatat ttttcctttg gataatattg caacggagca
     6541 tccgttttta catttcatag ctaaatatat aataatggca aggattgcgt cttgtaatat
     6601 aaaaccttgg ttaaatctga cgcataagaa aaaagctatt ttatttcgct ttataggaat
     6661 aattgggaca ttgttaggat ttcgaagaac agcaaaatta acggataaga tagctaaaat
     6721 agataagggt aaaacgaata aaagggtggg ggtttttgtt gaaagcatag gagagcataa
     6781 tatatttgca acagaatatt ttgcttctac aatacagttg aaatttgagg gaatatattt
     6841 taatgctcca aaggaatatc gaaaatgttt gactcagctt tatggagatt atatgcaact
     6901 acctcccgaa aatagacgta tttctggtca ttcatttaaa gcatgttaca gattatgaaa
     6961 ctaacaacat atgttcttaa tttattgaaa gataaagaac gaaaagaata tatgcaatat
     7021 gtattgagcg attatcctaa tctagatatt caatatgtta atgcaataaa tggaaaaaat
     7081 cttagtctgg atgagatatt gaatcaattt gataataata aagcatacaa acgctatgga
     7141 agagaatgtg atttaggaga aattgggtgc agtttgagtc atcgattggc gtttgattta
     7201 ttaatgaatt cggagagtaa ctatgcttta attttagaag atgatattgt tattggggat
     7261 ggatttagta gcgtattgga aaaattattg ccattgattg atatcgatgc tccttgtgtt
     7321 attttattgt caggtggtgt ctcttattat aaaaaaagat attataatac tttgtgtttg
     7381 ggtgtagttt atatgggaga ttatgcgcat agttatttaa taaataaggc tgctgctaaa
     7441 ttaatattgg atgataaaaa agcgtatata tttgctgatg attgggatta tatacgtaat
     7501 agaggagtaa atgtactagt tattttacct catttagttg atcaacgtag agatggaagt
     7561 tttgtaagta atgtttggca agataatcac catattgtga aggtgaaatt atcattgatt
     7621 aggttgtgta actatattct ttcaaggata atagataaaa tattgaagcg aatgggaaat
     7681 tatgagaata agacactgta gtatggttga atcacgttct aaaaaaggta tagcaaatat
     7741 aaaatgttct ttgttttttt atattataaa cttatttctt aatattatat ctagaaaggt
     7801 ctttatcgat tatttaggaa tagaagtact aggacttaac acaacagtta ctaatctgct
     7861 tagttttcta aatttggcag aattgggaat tggtaacgca attgcattta ctttatataa
     7921 acctttattt ttgaaagatt ttcaagttat aagggagata gtgtctgttc aagcttggct
     7981 ttatcgacga attgcatatt ttatatctat aggtgcttta ggactaatgt tgctttttcc
     8041 tgtaattttt aaaaaaatag atttaccttt gtggtatgct tatgctacat ttattgtttt
     8101 attgatagct tctttgttga gctattttgt gaattataaa cagatacttc taagtgcaga
     8161 tcaaaaagaa tacaaaataa cactttgtgt acagggaata aaatcattaa aaaccataac
     8221 acaagtggtt gttatattat atctaataaa tgggtatgtg tattggttaa ctcttgaact
     8281 tgtgggggta ttggtttcag ctttgctatt aaataaaatt gtaaacaaag aatatccttg
     8341 gttgtttgta aaggtctctg atggaaaaaa tttacgtaat aaatatccag aaataatagt
     8401 aaagacaaaa cagttttttt ttcatcgcat ctcatcattt gttttaaatc aaactagtcc
     8461 attgataatc tatgcctttg ctagtcttac aatggtagca atctatggaa attatatgtt
     8521 gatagttttt ggtggaatag ctctggtaaa tgcttttttt aatggtttca atgctggagt
     8581 gggaaatctt gttgctgaag gagataagaa aaaaataaaa tctttttttt gggaaataac
     8641 ttcttttcgg atatggatag cagccatcat ttgtgtctgt ttttttaagt tgtgtcatcc
     8701 ttttatttca ttgtgggtgg gaaaggaata tgttttggat gaaatgacct ttatagtgtt
     8761 aactatttat gtttttatat cattaacaag agtaaatgaa gcttttctat ttgcttatgg
     8821 attatatcag gatatatggg ctcctataat tgaagctata ttaaacttgg gactttcggt
     8881 tttattggga tttatttggg gactaacagg aataatatct ggggttgtta ttagtttagt
     8941 tgtcattgta tgtatatgga aaccatattt tttatttaaa atgggtttca aagataatat
     9001 attagaatat gtctctagat atataaaata ttatatgatg attgctttat cttttatttt
     9061 gtcacattta attcttaata caatgtttat agacttccaa agttcatatt ggaagctttt
     9121 tgaatatgct tgtactgttg gaagctgtta tgctatattg agttttctct ttttttattt
     9181 atttgataat gggatgagac aatttactag acgtttgtta aatatatttc taaaataatt
     9241 tagtgataag gtgtagttgt tatatttagt ttttagctga aatagatttt gtcttgtatt
     9301 ataaaaaatg agtttttata tatttatttt tgttgttttg ctgtatttct cttttaggaa
     9361 atataataaa tatatttatt ggggaactat tttattactt tcattgatag cagggttgag
     9421 gtccgaaacg ataggagttg atactcacgc ttataaagat atatttatat ggatatcaaa
     9481 tgaagtatta tatccgatag aacctgcatg gtatttttta aataaattga ttgcttgggt
     9541 ggggggaagt tttaatttct tgttgtggat aacttcacta ttgactttaa taccaatagg
     9601 tgtagttagt ttacgatgta gcagtaatcc tcagatgagt ttgttttttt actatggatt
     9661 atatgcatat attaattcat ttaatggaat gagacagttt gttgctattt catttgtatt
     9721 attagcttat tcttatatca cacaaaagaa gaattttttt ttgtatttac taattgcatt
     9781 catattccat tattcagcga ttttttcttt cattgctatt ttggtagata aggtatcatt
     9841 aactaaacga cgtgtaattg gtggtatttt ttctagtttt tttgtaggta tgttttttaa
     9901 tgattctatg tttcttgttt tggctggtcc ttatgcaggt tatttagaat cttctgaggg
     9961 atatagggat aattttttat tggctgctat aatggcaatt ttgatgagtt gtttatatat
    10021 gtgtacgttt tttactttac gaagagaata taaacaaaat ttgtggacaa aaatgttttt
    10081 tgttggcatt attatattga atataactat gcggttagaa ttaggagctc gtattatttt
    10141 gtatttcaca ttatgccaaa ttatatttta cccaatgtat ttccgtcata atattgtcaa
    10201 aaataaaaga atggttgttt tgagtatttt attgtatact tcgttggttt ttatgaaaat
    10261 attaattttg ggtaatcaag gagaatattc tgtctatcct tataaaacaa tattatggta
    10321 agcattatta ttccttgtta caattcggga aaatatattt ctgaatgttt aaattctatt
    10381 ttagctcaaa catattctga atgggaagca atttgtgtta atgatggtag tactgataat
    10441 acaatggaat ttctgaatca atatgtaatg tcggataatc gatataaagt agtttctcag
    10501 cttaattcag gagtgtcagc agcaagaaat aaggctttat ctatatgcag gggggaatat
    10561 atttgctttg tagatagtga tgatatagta gaacc
//
