LOCUS       gnlProkkaHOFBLCLJ_65   13992 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HOFBLCLJ_65.
ACCESSION   gnlProkkaHOFBLCLJ_65
VERSION     gnlProkkaHOFBLCLJ_65
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 02:59:22
            Original ID  :: gnl|Prokka|HOFBLCLJ_65
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13992
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13992
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3644:3992]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3645..3992
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13992
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13992
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             3..206
                     /locus_tag="ctg65_1"
                     /transl_table=11
                     /translation="MAVRRDDDDIQDTEEYVEETPLSLDEVEKEMIRKALERHHGKRKS
                     AAKDLNISERTLYRKIKEYDLD"
     CDS             193..720
                     /locus_tag="ctg65_2"
                     /transl_table=11
                     /translation="MIWIKKITRPLLLVVLPVVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             725..1519
                     /locus_tag="ctg65_3"
                     /transl_table=11
                     /translation="MTSVNLQQWIQHPETLNRDTLYELRNQLARYPYFQSLRLLYLKNL
                     YILHDINFGAELRKAVLYIADRRKLFHLIEGERFAVESQKKGLPLSEVLKDEPTVDRTL
                     ALIDAFLSTAPEEVTSQTSFDYSMDYTAYLLEETPVADEPAEAMPKLKGHELIDNFIEK
                     SETDPVVYLKPLREEEKAKAASSAETNETGRTDETTETNTIEEEDDSCFTETLAKIYVK
                     QQRYSKALEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             1526..1921
                     /locus_tag="ctg65_4"
                     /transl_table=11
                     /translation="MYLLFIILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSVATAYVVPSSSAAKDVLLEQAQKEQQTNPYNMPTGTAAP
                     QTDATAPAESAPATEAPATETPAPVAE"
     CDS             2212..3600
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 90.5; E-value: 1.4e-27)"
                     /gene_kind="transport"
                     /locus_tag="ctg65_5"
                     /transl_table=11
                     /translation="MTEQLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AITTTFPEGAMLFGFKMQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGVFHTNIPAPILFCLVMLCVGTIAFFIYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSVMLIFVHTMFAL
                     PILNIWWFATVIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNSYCKGPVVDGAQTYDYTLPMAIFAMFGVLALIVALMLKVENKKKGYGLEEA
                     NIQK"
     CDS             3645..3992
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_6"
                     /sec_met_domain="PF05402 (E-value: 3.1e-17, bitscore: 53.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 1.1e-09, bitscore:
                     29.0, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKEKINLLEVIPCRNEHIKAEQEGETIVLSFPRFKRSWMSRYL
                     LPKGMSKDIHVRLEEHGTAVWNLIDGQRTVREIIEKLADHFQYEAGYESRVSTYLSQLQ
                     KDGFIKWIIIH"
     CDS             complement(3982..4269)
                     /locus_tag="ctg65_7"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLKDGKEASRLRRERRNDKLGRLRRNNDPYLLP
                     DTTPEEMERIIKDSEKKKEKDNSYFVWGTLIIMGVLIGCAVLLWAIIFNG"
     CDS             complement(4291..5355)
                     /locus_tag="ctg65_8"
                     /transl_table=11
                     /translation="MKKFIIATGLLVATSAYAQTEVLTGVTRGKDYGVVYALPKTQIEI
                     EIKANKVNYKPGEFSKYADRYLRLTNVSAEPEEYWELNSVKVKPVGVPNSEATYFVKLK
                     DKTVAPLMELTEEGLIKSINVPYSSNNAKNAANNAVAPQRKANPRDFLTEEILMASSTA
                     KMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNLQEEAMTEMFSGVRNK
                     EEKTFTVRLTPDKEFDNEVAFRFSKKLGIVANNDLAGTPFYISLKDLKTVKIPQEDGKK
                     KKEMEGIAYNVPGQAMVTLSDGKKKLYEGEIPVTQFGIIEYLAPVLFNKNSTIKVYFDP
                     VTGGLLKVDREESK"
     CDS             complement(5429..6940)
                     /locus_tag="ctg65_9"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITNRWNP
                     ETPVTIFAGPGNNGGDALAIARMMAEKGYKIEVYLFNTKGELSPDCQTNKELVEMMEEV
                     TFHEISTQFVPPTLTPEHLVIDGLFGSGLNKPLSGGFAAVVKYINASPAMVVSIDIPSG
                     LMGEENTFNVKSNIIRADVTFSLQLPKLAFLFAENTEFVGEWELLDIQLSEEGIEETET
                     NYEMLEIEEIRSLIKPRQQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPLCNNDILQTSAPEAMVETDVSETCFPVPTDTDDYQAVGIGPGLGRSEETEAALIEQ
                     LEHCQTPTVLDADALNILANHRHTLTHLPKGSILTPHPKELERLVGKCQDSYERLMKAC
                     ELAHTAKVHIILKGAYSAIITPEGKCYFNQTGNPGMATGGSGDVLTGVILALLAQGYPA
                     EDAAKIGTYIHGLAGDIAQKKQGMIGLIASDIVTCLPTAWRLVSE"
     CDS             complement(7472..8305)
                     /locus_tag="ctg65_10"
                     /transl_table=11
                     /translation="MTTKKLTGILSLFLCIICLVSCNDNDDNFSPITLEYEDPQIKFDN
                     ESRSYTLTPFSKETTPLFIKGGDGTYKVTNENEKVVQVNYHNGSLTLKAKEIGRASIKI
                     EDSSNNMYILSVVVKYRTLTHKAFTAKVIVKGDELTSEEHTELMNKVGNSYPINKYVFT
                     FMNAEDSKGTVDLYYSDNNMKTGNFEKEHIVLDEENAIPIKGEYKLSEYYRITIKEDNG
                     KVIDTFYITKNFLPLLNTRMNAHPLIQYCFVRDLTAQYKQDYLALENAYLIQIAE"
     CDS             8578..8802
                     /locus_tag="ctg65_11"
                     /transl_table=11
                     /translation="MMEKKRIGSNAGKVWRILNEKGEQSMFTLCHELGLTFEDVAIAIG
                     WLARENKILLRKKEGMLYASIENVEFTFG"
     CDS             8995..10539
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 56.1; E-value: 3.9e-17)"
                     /gene_kind="transport"
                     /locus_tag="ctg65_12"
                     /transl_table=11
                     /translation="MSSLKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASSLNNTD
                     LAHWLMYGGLGFMILGNGCFKPTVSSLVGQLYEPGDKRLDAAYTIFYMGVNVGSFAAPL
                     ICGFLGDTGNPQDFKWGFLASGIMTLFTVVLFETQKNKYLFSPSGEPIGIVPDARREKK
                     EDKAEHISHPKMDKRTKVRNIIIITALTVALIAFFSYAFSDDWISVGIFTACIVFPVLI
                     LLDGSLTKVERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTDRSIFGWEMPASW
                     FQSFNPLFVVILAYIMPGIWSFLNKRNMEPASPTKQAIGLLLLSLGYLFICFGVKDAIP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEDGKVKSILGYQIATMYDFFMLFVIMSGVASLILFLLSKKLQKMMHGVE"
     CDS             10581..11117
                     /locus_tag="ctg65_13"
                     /transl_table=11
                     /translation="MDTIQIKDKQFTVSIKEQDIQKEVIRVANEINRDLAGKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGVTSTGVIKEVIGLNEDIAGRTVVIVEDI
                     VDTGLTMQRLLDTLGTRNPEAIHIASLLVKPEKLKVNLNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             11151..11720
                     /locus_tag="ctg65_14"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMLDLEVPEDELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTSPLIDWYKNE
                     KKYQHINGLGTMDGIFADICEAVDKL"
     CDS             11733..12899
                     /locus_tag="ctg65_15"
                     /transl_table=11
                     /translation="MAESNFVDYVKIYCRSGKGGRGSTHMRREKYCPNGGPDGGDGGRG
                     GHIILRGNRNYWTLLHLKYDRHAMAGHGESGSKNRSFGKDGADKVIEVPCGTVVYNAET
                     GEYLCDVTDDGQEVILLKGGRGGQGNSHFKTATRQAPRFAQPGEPMQEMTVIMELKLLA
                     DVGLVGFPNAGKSTLLSAISAAKPKIADYPFTTLEPNLGIVSYRDGKSFVMADIPGIIE
                     GASQGKGLGLRFLRHIERNSLLLFMVPADSDDIRKEYEVLLNELRTFNPEMLDKQRVLA
                     ITKSDMLDQELMDEIEPTLPEGVPHIFISSVSGLGISVLKDILWEELNKESNKIEDIVH
                     RPKDVTRLQQELKEMGEDEELDYEYEEDADDDDDDLDYEYEEEDWEEK"
     CDS             12923..13708
                     /locus_tag="ctg65_16"
                     /transl_table=11
                     /translation="MLGYESLSSYSNISHFVTTRQGGYSEGNYASFNCTPYSGDEAEKV
                     RRNQTLLMEGMSQTPEELVIPVQTHETNCLLIGDAYLSASSQQRQEMLHGVDALITREP
                     GYCLCISTADCVPVLMYDKKHSAIAAIHAGWRGTVAYIVRDTLLRMEKEFGTSGEDVVA
                     CIGPSISLASFEVGEEVYEAFQKNGFDMPRISIRKEETGKHHIDLWEANRMQILAFGVP
                     SGQVELARICTYIHHDEFFSARRLGIKSGRILSGIMIHK"
ORIGIN
        1 aaccggctgt tcgcagggac gatgacgata tacaggatac ggaagagtat gtagaagaaa
       61 ctccgctgtc tttagatgaa gtagaaaaag aaatgatacg caaggcactt gagagacatc
      121 atggaaaacg gaagagtgcg gcaaaagatt tgaatatatc agagcgtacg ctttatagaa
      181 aaataaaaga atatgatttg gattaagaag ataacacgcc ctctgttact ggtcgttttg
      241 ccggtagtgg tcatagcgtg cactgtttcc tataagttta acggttcatc catcaactat
      301 gataaggtga agacaatctc cattgccgac ttcccgatta agtcggagta cgtatatgct
      361 ccgttggcga cgaagttcaa tgaagacctg aaagatatat ttatccgtca gacccgcctg
      421 caattgctga aaccgaatca gaatgcggac ttgcagattg acggagaaat cacgggatac
      481 aatcagtaca accaggcagt atccgccgat ggttattctt cggaaacgaa gttgaccata
      541 acagtcaatg tacgctttgt caacaacaca aatcacgccg aagacttcga acaacaattc
      601 tcagctttcc gtacctatga ttccagccag ctactgacag ccgtacagga tggattaata
      661 gcggaaatga gtaaagagat aaccgaccaa atatttaatg caactgtagc aaactggtaa
      721 tttaatgact tctgttaact tgcaacaatg gattcagcat cccgagacgc tgaataggga
      781 tactttgtac gaactgcgca accagctcgc gaggtatccg tattttcagt cgctccggtt
      841 gttgtatctc aagaacctgt atattctcca cgacattaat ttcggtgcgg aactgcggaa
      901 agccgttctg tatattgccg accgacggaa actgtttcat ctgatcgaag gcgaacgctt
      961 cgctgtcgaa tcccagaaga aagggctgcc tctctctgaa gtattgaaag atgagcctac
     1021 cgtcgaccgg acactggctc tgatcgatgc tttcctttcg acggctcccg aagaagtaac
     1081 cagtcagaca agctttgatt actccatgga ctatacggca taccttctcg aagagacacc
     1141 tgtcgccgac gagccggcag aggcaatgcc caagctgaaa ggacacgagc tgattgacaa
     1201 ctttatcgaa aaaagcgaga ctgatccagt cgtatacctg aaacctttga gggaagaaga
     1261 gaaagcaaag gcagcttctt ccgctgaaac aaacgaaacg ggcagaacag acgaaacaac
     1321 tgaaaccaac accatagaag aggaagatga cagctgtttc acagaaactt tggccaaaat
     1381 ctacgtaaaa cagcaacgat attcgaaagc tcttgaaata attaaaaaat taagcttgaa
     1441 atatccaaaa aaaaatgctt actttgcaga ccaaatcaga tttttggaga aattgattat
     1501 taacgctaat tcaaaataac taaaaatgta cttattattc attatcttaa tggtgattgc
     1561 agccttgctg atgtgcttca tcgtgctgat tcagaattca aaaggaggcg gacttgcttc
     1621 tggtttttct tcatcaaacg ctatcatggg cgtgcgcaag actacagatt ttctggaaaa
     1681 agcaacttgg ggtctggcta tcttcatggt tgtgatgagc gttgctactg cttacgttgt
     1741 tccttcttct tctgcagcta aagatgtatt gttggaacaa gcacagaaag aacaacaaac
     1801 caacccgtat aatatgccta ccggtactgc tgctcctcag acagatgcta ctgctcctgc
     1861 agagtctgca ccagcaacgg aagctccggc tactgaaact cctgctcctg tagcagaata
     1921 attcagtgac aggatattcg gtttaaactt attgagtgaa cgggcttttt gacccgttct
     1981 cttcattata ggcgcgaatt acgcgaatta caagagattc taatagaatc gtgtaatacg
     2041 tgtagttcgc gcctgtcttt attattgggc ccggtctgct cttcttcata caggaatatc
     2101 cggtcagatg tcctttttct tataaaatgt tctccttttt tagtaaaaca aatgataatt
     2161 agttaacttt gttgcccgtt acgagattat taactccttt taaatattac aatgacagaa
     2221 caattgaaac aaaagctgaa tgactccgca gtgctgcgtt ggagtgttct agcattagtc
     2281 gcttttacca tgttgtgcgg ctacttcctc acagacgtta tgtctcctct gaaacccatg
     2341 cttgaaaaag aacttctctg ggacagttta gattacggtt ttttcaccag tgcttatggc
     2401 tggtttaatg tattcctgct gatgctcatc tttggtggta tcattctgga taagatggga
     2461 gtacgcttca ccggaatggg tgcctgttta ttgatggtgt tcggttgtgg attgaaatat
     2521 tatgctatta ctactacttt cccggaaggt gcgatgcttt tcggattcaa gatgcaagtc
     2581 acattggctg cattgggtta tgctattttc ggtgtaggag tcgaaattgc gggtatcacc
     2641 gtttcgaaga ttatcgtgaa gtggtttaaa ggcaaagaga tggctctcgc tatgggactg
     2701 gaaatggcga ccgcgcgtat tggaacaact ttggccatgg tgcttaccgt tcctttggca
     2761 gacttcttcg ggtctacgga tgagagcggc gtattccata ccaatattcc cgctcctatt
     2821 ctgttctgtc tcgtcatgtt gtgcgtaggt accatcgcat tcttcatcta tactttctac
     2881 gataagaaac tggatgcttc actggatgcg gaaggactgg aaccggaaga acctttccgc
     2941 atgaaagaca ttgtctatat cattaccaac aaaggattct ggctgatcgc attactgtgc
     3001 gtattgttct attcggctgt attccccttc atcaagtatg cggccgattt gatggtacag
     3061 aagtacaatg ttgatccgaa acttgcggga acgattcccg gattgctgcc gattggcgcg
     3121 atcatcctga caccgttgtt cggttcattg tatgaccgta tcggtaaggg agccacgctg
     3181 atggtgatcg ggtcggtgat gctgattttc gtacacacga tgttcgctct tcctattctg
     3241 aatatatggt ggtttgcaac ggtgatcatg attattctgg gatttgcttt ctcattggtt
     3301 ccttcggcaa tgtggccttc ggttccgaag attattccgg agaaacagtt gggaacggct
     3361 tatgcgctga tcttttgggt acagaactgg ggattgatgg gcgtgccttt gctgatcgga
     3421 tgggtgttga actcttattg caaaggtccg gttgtagatg gtgcacagac ttatgattat
     3481 accttgccga tggctatttt tgctatgttc ggtgtacttg ccctgattgt tgccttgatg
     3541 ctgaaagtgg aaaacaagaa gaaaggctac ggactggaag aagcaaatat tcagaaataa
     3601 tcacagtata tattctatct gaaaagatat aaaagagaaa agatatggct acgaaagaga
     3661 aaataaacct cctggaggtg atcccttgtc gtaacgaaca tattaaagct gaacaggaag
     3721 gggagactat tgtgctctcc ttccctcgtt ttaaacgttc gtggatgagt cgttatttat
     3781 tgccgaaagg aatgtccaaa gatattcatg tgcgtctgga agaacacggt acggccgtat
     3841 ggaacctgat agacgggcag cggacggttc gtgagattat agaaaaactc gcagaccact
     3901 ttcaatatga agcaggctac gagtctcgtg tatctaccta tctttcccaa ttacagaaag
     3961 acggatttat taaatggata attatccatt aaaaatgatt gcccacagga ggacagcaca
     4021 tcctatcagt acgcccataa tgataagcgt tccccatacg aaatagctgt tatctttttc
     4081 ttttttcttt tccgaatcct tgatgatgcg ttccatctct tccggagtcg tatccggcag
     4141 aagataaggg tcgttgtttc ttctaagtcg ccctaacttg tcatttctcc gttcacggcg
     4201 taagcgggag gcttctttgc cgtctttcag ccgacgtatc atgtcgagca tatgtccttc
     4261 gccacccatc gttttgtttt tttagaggtt ttatttgctt tcttctctat ctactttcag
     4321 tagtccaccg gtcaccggat caaagtaaac tttgatggtc gagttcttgt tgaataatac
     4381 cggagcaagg tattctatga taccgaactg agtaacaggt atttctcctt catacaattt
     4441 ctttttgccg tccgacagcg tcaccattgc ctgtcccggt acgttataag caatgccttc
     4501 catctctttc ttcttttttc cgtcctcttg cggaatcttc accgttttca ggtctttcag
     4561 actgatgtag aatggagtgc ctgccaaatc gttgttggca actataccca gcttctttga
     4621 aaagcggaaa gctacctcat tgtcgaattc cttatccgga gtgaggcgga cagtaaatgt
     4681 cttttcttct ttattgcgga ctcccgaaaa catctcggtc atggcttctt cctgaagatt
     4741 caggttgtcg agcatgattt tgagttgtgc gccgtccgaa ggcatattat ctgcttgtcc
     4801 gcgcaataat gcgtttttac tttcgcggat attatagatt tcctttgcta ccaattcggc
     4861 catcttggcg gttgaacttg ccatcagaat ttcttctgtg agaaagtcgc ggggattggc
     4921 ttttcgttgg ggagcaacgg cattgtttgc tgcattcttt gcattgttgc tgctgtaggg
     4981 gacgttgatt gatttgataa gaccctcttc agtcagttcc ataagaggag ctacggtttt
     5041 gtctttcagt ttgacgaaat aagtagcttc gctgtttggt acacctacag gtttcacttt
     5101 gacactgttc agttcccagt attcttcggg ttcggcagag acgttggtca gtctcaggta
     5161 gcggtcggcg tatttgctga attcacccgg cttatagttg actttgtttg cttttatttc
     5221 tatttctatc tgggttttgg ggagggcgta cactactccg tagtcttttc ctcgcgtcac
     5281 tcctgtcagc acttcggtct gcgcataggc ggaagttgcc actagtagtc ctgttgctat
     5341 gataaacttt ttcatattcg gttcttttta gctgattttg aaaaacaaag ttaatgaagt
     5401 tattgaataa accgtaagtt cttaactttt attcgcttac aagtcgccat gccgtcggca
     5461 gacaggtgac gatatcactt gcgattaatc cgatcatgcc ctgttttttc tgggcgatgt
     5521 ctccggccaa tccgtgaatg taagtaccga tctttgcggc gtcttcggcg ggatagcctt
     5581 gcgcaaggag tgcaaggatt actcctgtca gtacatctcc gctgcctcct gttgccatac
     5641 cgggattacc ggtctggttg aagtaacatt tgccttcggg ggtgataatg gcggaataag
     5701 ctcccttcag aatgatatgt actttggcag tgtgcgccag ttcgcaggct ttcatcagtc
     5761 gttcgtatga gtcctgacat ttgccgacca ggcgttccag ctctttcggg tgaggggtga
     5821 ggatggaacc tttcggcaga tgggtgagcg tatgccggtg attggccaga atattgagtg
     5881 cgtcggcatc cagtaccgtc ggagtctgac aatgttccag ttgttctatc agggcggctt
     5941 ccgtttcctc gctgcgaccg agtcccggac cgatgccgac agcttggtaa tcgtccgtat
     6001 cggtagggac gggaaagcat gtttcgctga catccgtttc taccatggct tcgggggcgg
     6061 acgtttgcaa aatatcgttg ttgcataacg gcgcgtgtac ggtcagcaga cctactcccg
     6121 atcgcagaca ggcacgggcg gccagtaccg atgcacctgc cattcctttt gagccggcta
     6181 tcagcagggc atgtccgaag tttcctttat gggcgaattg ttggcgtggt ttgattagcg
     6241 aacggatttc ttcgatttcc agcatttcgt agtttgtttc agtctcttcg attccttctt
     6301 cgctcagctg gatgtccaat aactcccatt cgccaacaaa ttctgtattt tcggcaaaga
     6361 ggaaggccag tttaggaagt tgcaggctga aagtgacgtc cgcacggata atattgcttt
     6421 ttacattgaa tgtattttct tctcccatca gtccggaagg gatgtcgatg gagactacca
     6481 tggcgggaga ggcattgata tatttcacaa cggcagcgaa tcctccgctc aatggtttgt
     6541 tgagtccgga accgaataat ccgtcgatca cgagatgttc cggtgtcagt gtgggaggta
     6601 cgaactgggt gctgatttca tggaaagtta cttcttccat catctctacc agttctttgt
     6661 tggtctgaca gtcgggcgaa agttcgcctt tcgtgttgaa gagatatact tcgatcttgt
     6721 atcctttttc cgccatcatg cgggcgatgg cgagggcgtc tccgccatta ttgcccggtc
     6781 cggcaaagat ggtgacaggt gtttccggat tccatctgtt ggtgatggct ttagtcagcg
     6841 cctgtgcggc acgttccatt aaatctatgg atgcaatcgg ttcatgttca atggtatagg
     6901 catctaactt cttaatgctg ctgcttggaa atattttcat tgcgatattc ttttagtttt
     6961 cgacgcacaa acttacacaa aaactctgaa ttaatccttt attccggttg gttttcggct
     7021 ttttgggaag gaacttcagg tattaatact tgagttgtca ggtattaata gttgatgtgt
     7081 cagttattaa tagttgagaa gtcagatatt aatgattgtt atggtagata tcaatgcttg
     7141 ttatgatggc tttcaatgct tgtaacgcag tataacaagc attgttatct catttacttt
     7201 tactctctcc ggagaacatt catggctgtt tgttaacctt cccatgcgtg tttctactac
     7261 tgtatattcc tctggttcac ctctttcacc cgcaatcgcc ttattcatca aaggttcagg
     7321 aaaagggtgg aagaggtgat tgtgataaat atgctatggg catattcttg attagctaat
     7381 agcttattgt tttttgctaa atctaatggg gagtttgctc atataataaa tactctattc
     7441 actctgctaa agaagaaaat cagtgtagct ctcattctgc tatttgaatc agatatgcat
     7501 tttccagtgc aaggtaatct tgtttgtact gtgcggttaa atctctgaca aaacagtact
     7561 gaattaacgg atgagcattc attcttgtat tgaggagtgg tagaaagttc ttggtaatat
     7621 agaaagtatc aataactttg ccattatctt ctttgattgt tatacggtaa tactcactca
     7681 atttgtattc acctttgatg ggaatggcat tttcttcatc cagcactata tgttcttttt
     7741 caaagttgcc tgttttcatg ttattatctg aataatacaa atctactgtt cctttgctgt
     7801 cttccgcatt cataaaagta aatacatatt tattaatcgg atatgaattg cccactttgt
     7861 tcattaactc agtgtgttct tcagatgtaa gctcgtctcc cttcacaatg acttttgctg
     7921 taaacgcctt atgagtaaga gtacgatatt ttacaacgac agacagtata tacatattat
     7981 ttgaactgtc ttctatcttg atggatgcgc gtcctatttc ctttgccttc aatgttaaac
     8041 ttccgttgtg gtagtttact tgtaccactt tctcattctc attggtcact ttgtaagttc
     8101 cgtctccacc cttgatgaag agtggtgtcg tttctttgct gaacggagtc agtgtgtaag
     8161 aacggctctc gttgtcgaac ttaatttgag gatcttcata ttccagagtg attggagaaa
     8221 agttgtcatc attgtcatta cagctcacga ggcaaataat acaaaggaat aacgaaagta
     8281 ttcctgttag ttttttggta gtcatgctaa ttaaagtttt aaatgtgcga tattagttta
     8341 gttctcgtct gcaaacttat gaaaaagaat tgaactgttt ctttatttgt gctatttttt
     8401 agcagagatc ggcataaatg attagaatgt aactaataat agcagctaat gctttgatta
     8461 tttgcttttt tcgaaaaaaa tgatatcttt gtagtgcagt aatgtgcttt acgttattct
     8521 cctgtgctca caatgtttag attataaata taaattgttt aatcttctaa agtttgcatg
     8581 atggaaaaga aaagaattgg ctcaaatgcc gggaaagtat ggcgcatctt aaatgaaaag
     8641 ggcgaacagt ctatgttcac tttgtgccat gagttaggtt tgacgttcga ggatgtagcg
     8701 attgctatcg gttggctggc aagggaaaac aaaatcctgc ttagaaaaaa agaaggaatg
     8761 ctctatgcca gtattgagaa tgttgaattt acctttggat aaatggggac tgacccacat
     8821 ttaaggagaa tatccacttg attatttaca ctgttgaaaa cataataagg tgggtaactg
     8881 agactttttg cacgccatcc tgtatttttc tattccataa gaatcttctt ttttgaggca
     8941 tttaatctac tttttagtac ctttgcaccc cataaactac taaacacata attcatgagt
     9001 tcattgaaag ggcacccgaa aggcctttac ctaattttcg caacgagcac ggcagaacgt
     9061 ttcagttact acggtatgcg tgctatcttt atcctctttc tgacgcaggc attgcttttt
     9121 gataaagaag cggcggcctc tatctacggt agctacaccg gactggtcta tctgactccg
     9181 ttgatcggcg gatacattgc cgataaatat tggggcatcc gtcgttcggt attttgggga
     9241 gcggtgatga tggcagtcgg tcagttcctg atgtttatga gtgcctcttc actgaacaat
     9301 acagaccttg cccactggct gatgtatggc gggctcggat tcatgatttt aggtaacggt
     9361 tgctttaagc ctaccgtttc ttcgctcgtc gggcaattat atgaacccgg ggacaaacgg
     9421 ttggatgctg catacaccat tttctatatg ggtgttaatg taggttcttt tgctgctcct
     9481 ttgatttgcg gtttcttggg agacacaggg aatccgcagg actttaaatg gggattcctc
     9541 gcatccggaa tcatgacgct gttcactgtt gtcctctttg aaactcagaa gaataaatac
     9601 cttttctctc cttccggtga accgattggt atcgtccccg acgccagacg tgaaaaaaag
     9661 gaggataaag ccgaacatat ttcacatccg aagatggaca aacgtaccaa agtacgtaat
     9721 atcatcatca ttactgccct tacagttgcc ttaatagctt tttttagcta tgcctttagc
     9781 gatgactgga ttagtgtggg tatctttacg gcttgtattg tctttccagt gctcattctg
     9841 ctggatggtt cattgaccaa agtagaacgt agccgtattt tcgtaatcta tatcgtagct
     9901 ttcttcgtca ttttcttctg ggcagcttac gagcaggcag gagcttctct gacattattc
     9961 gcttccgaac agactgaccg cagcattttc ggctgggaga tgccggcttc gtggttccag
    10021 tcattcaatc cgctttttgt agtgatcctt gcctatatta tgcccggtat atggagcttt
    10081 ctgaataagc gaaacatgga accggcttcc cctaccaaac aggcaatcgg tctgttactg
    10141 ctttctcttg gttatctctt catctgtttt ggagtgaaag atgctattcc gggagtaaag
    10201 gtgagcatga tctggctgac agggctttac tttattcata caatgggaga aatcgctctg
    10261 tcacctatcg ggctttctat ggttaataag ttgagtccgt tacgtttcgc ctccttgatg
    10321 atggggatct ggtatctttc taccgccacc gcaaataaat ttgcaggtat gctgagcggc
    10381 ctctatcccg aagacggaaa agtgaaatca atccttggtt atcagatcgc taccatgtac
    10441 gacttcttca tgctgttcgt cattatgtcc ggtgttgcct cactgattct gttccttctc
    10501 tcgaagaaat tacagaagat gatgcacggg gtagaataaa aaattgtatt tttgcgacaa
    10561 cttttttaaa atgaccggtt atggatacca tacagataaa agacaagcaa tttactgttt
    10621 ccattaagga acaggatatt caaaaagaag tgattcgcgt agcgaacgaa atcaatcgtg
    10681 atttggcagg taagaatccg ctcttcctca gtgtgttgaa cggctcgttc atgtttaccg
    10741 ccgacttgct gaagcatatc acgattccgt gcgaaatttc atttgtgaag ttggcatctt
    10801 atcagggggt gacttccacc ggagtaatta aagaagtgat cgggctgaat gaagacattg
    10861 ccggacgtac ggtagtgatc gtagaagata ttgtagatac cggactgacg atgcagcgtc
    10921 tgctggatac actgggcaca cgcaaccccg aagcgattca tatcgcctct ttgctggtga
    10981 aaccggaaaa gctgaaggtc aatctgaaca tagaatacgt agcgatggaa atcccgaatg
    11041 attttatcgt tggctacgga ttggattatg atggtttcgg acgcaattat cccgatattt
    11101 atactgtagt agattaaatt caaatacaaa ttaatttata ggttaaaaag atgttgaaca
    11161 ttgtaatttt cggtgctccg ggttcaggaa aaggaacgca gagcgaacgt attgtagaaa
    11221 agtatggaat caaccacatt tcgacaggag atgtattgcg tgcagaaatc aagaacggca
    11281 cggaactggg caaaactgct aaaggttaca tcgaccaggg tcagttgatt ccggatgaat
    11341 tgatgattga tattctggca agcgtattcg atagcttcaa agacagcaaa ggtgtaattt
    11401 tcgacggttt cccaagaaca attgcacagg cggaagcatt aaagaagatg ttggcggaaa
    11461 gaggacagga tgtttctgta atgttggatc tcgaagttcc ggaagatgaa ctgatggtac
    11521 gtctgatcaa acgtggcaaa gactccggtc gtgccgacga caacgaagaa acaatcaaaa
    11581 aacgtctgca tgtgtatcat tcacagacat ctccgctgat cgactggtac aagaacgaaa
    11641 agaaatacca gcacatcaac ggtctgggta ctatggatgg tatcttcgct gatatctgcg
    11701 aagcagtaga caaattataa taaataaaaa atatggctga atcgaatttt gttgattacg
    11761 taaagatata ctgtcgctca ggcaagggcg gaagaggctc tacgcacatg aggcgcgaga
    11821 aatattgtcc taacggaggt cccgatgggg gcgatggtgg aagaggaggc catattatct
    11881 tgcgcggtaa ccgtaattac tggacattgc ttcacttgaa gtatgaccgt catgcgatgg
    11941 caggtcatgg cgaatcgggc agcaagaacc gtagtttcgg aaaagacggt gcggataaag
    12001 tgatcgaagt accctgcgga acggtagtgt ataacgccga aaccggagaa tacctttgcg
    12061 atgtgacgga cgacggacag gaagtgatct tgctgaaagg cggtcgtggc ggtcagggta
    12121 acagtcattt caagacggct acccgtcagg ctccgcgctt tgcgcagccg ggcgaaccga
    12181 tgcaggaaat gacggtgatc atggagctga aactgttggc agatgtagga ctggtaggtt
    12241 tcccgaatgc gggaaagtct acgttgcttt ctgccatttc ggctgcgaaa ccgaagattg
    12301 ccgattaccc gtttacgaca ctcgaaccga atctgggaat tgtttcctat cgcgatggaa
    12361 agtcattcgt gatggcggac ataccgggca tcatcgaggg agccagtcag ggaaaaggat
    12421 tgggactgcg gtttctgcgt catatcgagc gtaactcgtt gctgttgttc atggttccgg
    12481 cagatagcga tgatatccgc aaggagtatg aagtattgct gaatgagttg cgtacgttca
    12541 atcccgaaat gctggacaaa caacgtgtgc tggctatcac gaagagcgat atgctcgatc
    12601 aggagctgat ggacgagatt gaaccgacat tgcccgaggg tgttccgcat atattcattt
    12661 cttctgtttc cggtttggga atctcagtgt tgaaagacat tctgtgggag gaactgaaca
    12721 aggaaagtaa taagatagaa gacattgttc accgtccgaa agacgtgacc cgtctgcaac
    12781 aggaactcaa agagatgggc gaggatgaag aactcgacta tgaatatgag gaagacgctg
    12841 acgacgacga tgatgatctc gactacgaat acgaagaaga ggattgggag gaaaaatgat
    12901 ttcaatcaca agagataaaa gaatgttggg gtatgagtcg ttaagctcat actccaacat
    12961 ttctcatttt gtaactaccc ggcagggagg gtacagcgaa ggaaattatg cgtcattcaa
    13021 ctgtacgccc tacagtggag acgaggcgga aaaggtccgg cggaatcaaa cgcttctgat
    13081 ggaaggaatg tcgcagacac ccgaagaact ggtgattcct gtgcagactc atgagacgaa
    13141 ttgcctgctg atcggggatg cttatttatc ggcttcgtct caacaacgac aggagatgct
    13201 gcacggagtg gatgctttga ttacccgcga gccgggatat tgtctttgta tttctactgc
    13261 ggattgtgtt cctgtgttga tgtatgataa gaaacatagt gccatagctg ccattcatgc
    13321 cggatggaga gggacggtag catacatcgt gcgtgatact ttgttgcgga tggaaaagga
    13381 gtttggcaca agtggagaag atgtagttgc ctgtatcggt ccgagtatct cattggcttc
    13441 ttttgaagtg ggtgaggaag tgtacgaagc atttcagaag aatggttttg atatgcctcg
    13501 tatttctatc aggaaagagg aaaccggaaa acatcatatc gacttgtggg aagcgaaccg
    13561 gatgcaaatc cttgctttcg gtgtgccgtc cggccaagtg gagcttgccc ggatatgtac
    13621 gtatattcat cacgacgagt ttttctcggc aaggcgtttg ggcattaagt ccggacggat
    13681 tctgtcgggg atcatgattc ataaataata gacttgaacg taagttgata taaacttgaa
    13741 taaaagtatg tttgaaataa aagtatctca ggaaataaag aacacctgcc ctgtttttgc
    13801 cggagcagcc gtatatgcag cagtgaagaa tactgcttac tgcgatggac tttggaaaga
    13861 aataaatact ttcacagaag acttgactac caccacccaa atggcagaca ttaagttgca
    13921 acctgtgatt gctgctaccc gtgaggctta taagcgttgc ggaaaagatc cggggcgtta
    13981 tcgtccgtcg gc
//
