LOCUS       c00116_gnlPro..        14118 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ELNDJKNA_116.
ACCESSION   c00116_gnlPro..
VERSION     c00116_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 16:43:59
            Original ID  :: gnl|Prokka|ELNDJKNA_116
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14118
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14118
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6544:11253]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6545..11253
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14118
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14118
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(2..100)
                     /locus_tag="ctg116_1"
                     /transl_table=11
                     /translation="MKKGIHPENYRPVVFKDMSNGDVFLSRSTCNTK"
     CDS             292..1299
                     /locus_tag="ctg116_2"
                     /transl_table=11
                     /translation="MRKLLVLCSFWLCVATLGAQNAERKLYSVAFYNLENLFDTVHDAG
                     KNDHEFLPDGSYQWTAKKYESKLQNLSKVLGSLSRDLVPEGPAFIGVAEVENSRVLEDL
                     VKQPAISNYEFVHYEGPDRRGIDCALLYDPKQFSVTHSKLVLSTPFEGDTVHLTRGFLI
                     VDGQLAGERVCVIVNHWPSRGAKSPVRVHAARQVKALKDSLMRSDKKLKLIVMGDMNDD
                     PMDESMKVLGARKYPKQVKKGEFYNPWWETLEDKGVGTLLYRGKWNLFDQIVISKPLLK
                     AKKGLRYDHNEVFIRDYLIQQDGKYKGSPLRTHGGRTWLNGYSDHLPTIIYLKN"
     CDS             1582..2592
                     /locus_tag="ctg116_3"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTREMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCKHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVDYAHQFDVTVEGELGVLAGVEDEVSAEHHT
                     YTNPEEVIDFATRTGCDSLAISIGTSHGAYKFKPEQCHVDPATGRLVPPPLEFAVLDAV
                     MEKLPGFPIVLHGSSSVPQEEVDTINKYGGKLEAAIGIPEEQLRKAAKSAVCKINIDSD
                     SRLAMTAAIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSENKLAQLD"
     CDS             complement(3063..4913)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg116_4"
                     /sec_met_domain="Alpha-amylase (E-value: 2.1e-64, bitscore:
                     207.8, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVFLILGTLLLSLSTYAAMNVNKIDPPFWYTGMQNPELQLMVY
                     GEGIGNAAVSVNYPGVSLSSTVKLESNNYLLVYLKLDKDVKPGKFNLTFTEGKKKLVKE
                     YELKARNKKGCEHKGFDASDALYLLMPDRFANGNPDNDQIAGMAEYKIDRNDPNARHGG
                     DLAGIEQHLDYFSDLGVTALWFTPVLENNMTGGSYHGYATTDYYKVDPRFGTNEEYKQL
                     IEKAHARGIKIVMDMIFNHCGVEHVWIKDMPSKDWFNNPDHENNFVQTSFKLTPHVDPY
                     TSQYDADQMNDGWFVPSMPDLNQKNPHVYRYLVQNSFWWIEFANIDGIRMDTYPYADYD
                     AMSNWMKELNEEYPNYNTVGETWVTEPAYTAWWQKDSKLSAPKNSNLKTVMDFSFFDKI
                     NTAKNEQTETWFKGLDRIYNNFVYDFLYPNPASVLAFIENHDTDRFLGEGNNLPMLKQA
                     STLLLTTRRIPQLYYGTEVMMNGVKSKSDGYVRKDFPGGWTGDATNALTPAGRTKIQNE
                     CYDFYKTILNWRKGNDVIAKGSMVQFMVQNGVYAYARQYEGKTIFVMLNGTDAETTVPL
                     KFYKEILKNSKQGKDILSGKAITFGEELKMGPRESLVIEL"
     CDS             complement(5023..6375)
                     /locus_tag="ctg116_5"
                     /transl_table=11
                     /translation="MRKLFISLCFSACCSLLAAQTTNPIQEAMANYDYETALMLIDQET
                     PTVPLLYQKGKALKGLGNNLEALSVFQEVVAQDSLNPRAYIEAAECCKSLAKYSEALDY
                     YQNALHINPDNKYARIQYISLLMNMKRYRESLKESNLLAERDSSTYVLHLRAESMGQVY
                     DNTEIMHVIDAYLDIQKRYPNDYLSAAKLGNIYVAGHQYEDAINITEKYRSIDSTNVLV
                     NRINAQAYCLNKDYPKAIERYEQLLQEKDSSFQTCFYAGISYYALEDFYPAHDLLERAL
                     KDDNTNINVLYYLGRACSKTSWKEDGVTYLETAVSLAMPSDSVMSRLYVGLADCYKMAF
                     QYTDQANTLLTQYEKYDRQKHKLLYDAAFIYYYYLKDASKAERYLTAYLKTRPKNSKDK
                     VQEVDADGVPIIGEDNRYNAAENWLKDIREKRKKEDFFKGKVDTASVTPIK"
     CDS             complement(6545..7705)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_6"
                     /sec_met_domain="OAD_beta (E-value: 4.6e-153, bitscore:
                     498.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFITFLGNNLADFWTYTGFANATVGHVVMLLVGLFFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYMIALAIGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRWLTSKNERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTTFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFGLGALSFVIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(7707..8141)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.3; E-value:
                     2.7e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_7"
                     /sec_met_domain="Biotin_lipoyl (E-value: 5.3e-22, bitscore:
                     67.3, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKVV
                     VKPVARPAATSAPAAPATPVVKPAAASTGKSGVKSPLPGVILDIKVNVGDTVKKGQVII
                     ILEAMKMENNINADKDGKITAINVNKGDSVLEGTDLVIIE"
     CDS             complement(8165..9097)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_8"
                     /sec_met_domain="OAD_gamma (E-value: 1e-17, bitscore: 54.3,
                     seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLMLVLGFCSSCKEQKSNNKLLLNEVLVNNESNYQ
                     DDYGVHSAWIEIFNRSYGSADLAGCYLKFSSQPGDTASYFIPKGDVLTLIKPRQHALFW
                     ADGEPRRGTFHTNFKLDATNANWIGLYDSGKKLLDQVIVPAGTLKANQSYARVSDAADQ
                     WEVKGGSEDKYVTPSTNNKTIDSNAKMEKFEEHDSVGIGMAISAMSVVFCGLILLYISF
                     KIIGKISVNLSKRNAMKAKGITDKQEAKEKQLGQAPGEVFAAISMAMHEFQSDVHDVED
                     TILTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             complement(9129..10682)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_9"
                     /sec_met_domain="CT_Btheta (E-value: 1.2e-291, bitscore:
                     956.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIDRRAAARLGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGLALIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDNPN
                     KPYDMYEVIGAIIDNGEFLEIQKDYSKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             complement(10741..11253)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_10"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.9e-26, bitscore:
                     81.2, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNFFIKEEFSFFVLLYTFIKKDTILTLIYIVMKISHIEHLGIAV
                     KSIEEALPYYENVLGLKCYNIETVEDQKVRTAFLKVGDVKIELLEPTSPESTIAKFIEK
                     NNGNGGMHHLAFAVEDGVAGALAEVEEKGIRLIDKAPRKGAEGLNIAFLHPKSTLGVLT
                     ELCEKPE"
     CDS             11447..12934
                     /locus_tag="ctg116_11"
                     /transl_table=11
                     /translation="MKKNILLAVCFLMPLATMAQNDTLGHERNITLSEAIVLARTQSVD
                     AAVALNELKTAYWEYRTFRADLLPEVNFTGTLPNYNKSYSTYQNSDGSYSFVRNNTLGL
                     SGQLSVDQNIWFTGGKLSLTSSLDYLKQLGSGGAKQFMSVPVSLELTQPVFGVNTLKWN
                     RRIEPVRYAEAKAEFISATEEVTMKTITYFFELLLAKESLATAMQNKTNADRLYEVAIA
                     KRKMGQISENDLLQLKLNSLQGKADVTEAESNLNAKMFQLRSFLGVSEQESLNPVLPAT
                     VPDIKMEYDRVLNKALERNSFAQNIRRRQLEADYEVATARGNLRSIDLFASVGYTGQNH
                     EFSSAYRDLLDNQIVQVGVKIPILDWGKRRGKVRVAKSNREVVLSRIRQEQMDFNQDIF
                     LLVANFNNQAQQLDIAEEADVIAEKRYKTSVETFMIGKISTLDLNDAQNSKDEARQKHI
                     SELYYYWYYFYQLRSLTLWDFERDTELEADFEEVVRG"
     CDS             13078..14118
                     /locus_tag="ctg116_12"
                     /transl_table=11
                     /translation="MILIIDDDSAVRSSLSFMLKRAGYEVKTAPGPREAMDIVRAEAPA
                     LILMDMNFTLSTTGEEGLTLLKQVKVFRPDVPVILMTAWGSIQLAVQGMQAGAFDFITK
                     PWNNAALLQRIETALELTAAPKEVPEEQTTALNRSYIIGKSKGLMEVLNTVARIARTNA
                     SVLITGESGTGKELIAEAIHINSQRVKQPFVKVNLGGISQSLFESEMFGHKKGAFTDAS
                     ADRIGRFEMANKGTIFLDEIGDLDPSCQVKLLRVLQDQTFEVLGDSRPRKVDVRVVSAT
                     NADLRKMVSERTFREDLFYRINLITVKLPSLRERREDIPLLARHFADRQAEVNGLPRTD
                     FSADALN"
ORIGIN
        1 ctttcgtgtt gcaagtggaa cgagacaaga atacatcacc atttgacata tctttaaata
       61 ctaccggacg gtaattttcg ggatgaatac cttttttcat tttgatattt tcttttaaaa
      121 atttatattc tgttactatt ttggtaataa atagtgtaat ggtcttcttt tcagagcgca
      181 aagatagtgc aagttggaga ctctacaaaa taaaatcaga tttattttca tttagtaggt
      241 ttatcgcatt ttatttctga cttttgcagt acttaataat cttgtgaatt tatgaggaaa
      301 ctacttgtct tatgctcttt ctggctgtgc gtggcaacgc tgggggcaca aaatgcggaa
      361 cggaaactgt atagcgttgc gttctataat cttgaaaacc tgttcgatac ggttcatgat
      421 gccggtaaga acgaccatga gttcctgccc gacggcagtt accaatggac ggcaaagaag
      481 tatgagtcta aactgcagaa cctttccaaa gtgttgggtt ccctttcgcg tgatttagtg
      541 ccggaaggtc cggcattcat cggtgtggca gaggtggaga acagccgggt gctggaagac
      601 ctcgtgaagc agccggccat ttccaattat gagttcgtgc attatgaagg accggacaga
      661 cggggcatcg actgtgcctt gttgtacgac ccgaagcagt tcagcgttac ccactcaaag
      721 ttggtgcttt ccactccttt tgagggggat acggtgcact tgacgcgcgg cttcctgatt
      781 gtggacgggc aactggcggg agagcgtgtc tgcgtgatag tgaaccactg gccctcccgt
      841 ggggcaaagt caccggtgcg tgtgcatgca gccaggcagg taaaggcctt gaaggactct
      901 ctgatgcgta gcgacaagaa gctgaaactc atcgtgatgg gggatatgaa tgacgacccg
      961 atggatgaaa gcatgaaggt gctgggtgca cgcaaatatc cgaagcaggt gaagaaaggc
     1021 gaattctaca atccctggtg ggagacactg gaagacaagg gagtggggac attgctctat
     1081 cggggcaagt ggaacttgtt tgaccagatt gtcatttcga aaccgttgct gaaggctaag
     1141 aaagggttgc gctatgatca caatgaagtt ttcatccgcg attatctgat tcagcaggat
     1201 ggcaaataca aaggttcccc cttgcgtacg catgggggca ggacttggct gaacggttac
     1261 agtgaccatt tgccgaccat catctatctg aaaaattagt attacataat aatgtgtaaa
     1321 cagatgccgg agagcaaaca tgttctccgg cttttttgtt gatagaagta tagatggcaa
     1381 aagtatggct ggcagagata aatgcaaaga gtttgtaata tagagattac aataatctgt
     1441 taaatgaagc caatagcttt aaaatagaat ggatttggta ggatgagccg gatattttat
     1501 tcctctcaag ttctttactt taaaggataa tgattacttt tgcgtagaat tttaattcac
     1561 taacaataaa atttaaacaa aatggttaat tacaaagatt taggactggt aaacacaaga
     1621 gagatgtttg ctaaggctat caaaggtgga tatgctattc cggcattcaa cttcaacaat
     1681 atggaacaga tgcaggctat catcaaggct gcagttgaaa caaagtctcc ggttattctt
     1741 caggtatcta agggtgcccg tcagtatgcc aacgctactc tgttgcgtta catggctcag
     1801 ggtgctgttg agtacgctaa ggaattgggt tgcaaacatc ctgaaattgt tcttcacctc
     1861 gaccacggag atacattcga aacttgcaag agctgtatcg actctggttt ctcttcagta
     1921 atgattgacg gttcacacct tccgtacgaa gaaaacgttg cactgactaa gaaggtagtt
     1981 gattatgctc atcagttcga cgtaactgta gaaggcgaac tcggtgtatt ggccggtgta
     2041 gaagatgaag tttctgcaga acaccataca tatactaatc ctgaagaagt tattgacttc
     2101 gctacccgta caggttgcga ttcactggct atctcaatcg gtacttctca cggtgcatac
     2161 aagttcaaac ccgaacaatg ccacgttgac cctgctaccg gtcgtctggt tcctcctcct
     2221 ctggaatttg ccgttctgga tgctgtaatg gagaaacttc cgggattccc catcgttctt
     2281 cacggttctt cttcagttcc tcaggaagaa gttgatacta tcaacaagta tggtggtaag
     2341 ctggaagctg ctatcggtat ccccgaagag cagttgcgta aggctgccaa gtctgctgtt
     2401 tgcaaaatca acatcgactc tgactcacgt ctggctatga cagctgctat ccgcaagaca
     2461 tttgctgaaa aaccggcaga attcgacccg cgtaagtatc tgggtccggc tcgtgacaat
     2521 atggaaaaac tgtacaagca taaaatcatc aacgtgcttg gttcagagaa caaattggct
     2581 caactggact aatcgaaaga taatccgaat atagcgtcag cccttgcaat attgatgttg
     2641 caagggctga cttgttgtat ataggccggt gttgtgggat ggttaagttc gccggttatt
     2701 tcagaagcgg atgtttcaac gtgtacaaca gtctgtttcc tttaacaaaa cagtctgttt
     2761 cccttaactg aacagtttgt ttcaataaag agaacacttc gttccaatat gcaaaaacac
     2821 ttcgttccaa tacgtaagaa cactttgttt ctacatatct gaacactttg tttctctata
     2881 ctggaacaaa gtgttcactg ttatgaacta acagattagc tatatttgag gccggtgaaa
     2941 ggcatatccc cgtgacacct gttccatact aaaaatccct tgcagatggc tggcaggaga
     3001 agtgtctgcc agctatctgc aagggagatt tgcaagaatg agctctctgt gtggagtacg
     3061 cgttataatt ctatcactaa tgattctctg gggcccatct tcagctcttc accgaaggtg
     3121 atggccttgc cgctaagaat atcttttccc tgcttgctgt ttttcaggat ttccttgtag
     3181 aatttcaaag gaacggtggt ctctgcatct gtaccgttca gcatcacgaa tatcgtcttg
     3241 ccttcgtact ggcgtgcgta ggcataaaca ccattctgta ccatgaactg caccatgctg
     3301 cctttggcaa tcacatcgtt tcctttgcgc cagttcagga tggtcttgta gaagtcgtag
     3361 cactcgttct gtattttggt acgtccggct ggggtcagtg cgtttgttgc gtcaccggtc
     3421 catccaccgg ggaagtcctt gcggacatag ccgtcgctct tgctcttcac gccattcatc
     3481 ataacttccg ttccgtagta gagttgcgga atgcggcggg tggtaagcag cagggtagag
     3541 gcttgcttca gcattggaag gttgttgcct tcgcccagga agcggtcggt gtcgtggttt
     3601 tcgatgaatg ccagtacgga agcggggttg gggtagagaa agtcgtatac gaagttattg
     3661 tatatgcggt ccagtccctt gaaccaagtt tcggtctgtt cattcttggc ggtgtttatc
     3721 ttgtcgaaga agctgaagtc cataacggtc ttgaggttac tgttcttggg ggctgatagc
     3781 ttggaatcct tctgccacca ggcggtgtag gcgggttcgg taacccaggt ctcgcccacg
     3841 gtgttgtagt tgggatattc ttcgttgagc tctttcatcc agttgctcat ggcatcatag
     3901 tcggcatacg ggtaagtgtc catgcggatg ccgtcgatgt tggcgaattc aatccaccag
     3961 aaactgttct gtaccaggta gcggtaaacg tgagggttct tctggttgag gtcgggcatg
     4021 gaaggtacga accagccgtc gttcatctgg tcggcatcgt actgggaagt ataagggtct
     4081 acgtgcgggg tcagtttgaa ggaggtctgc acgaagttgt tttcgtggtc ggggttgttg
     4141 aaccaatctt tggagggcat gtccttaatc catacatgct ctacgccgca gtggttgaaa
     4201 atcatgtcca ttacgatttt gatgccgcgt gcatgggctt tttcaatcag ttgcttgtat
     4261 tcttcgttgg taccgaagcg cgggtctacc ttgtagtagt ctgtggtggc atagccgtga
     4321 taggaaccgc cggtcatgtt gttttccagt accggagtaa accagagggc tgtgacgccg
     4381 aggtcggaga agtagtccag gtgttgttcg atgccggcaa ggtcaccgcc gtggcgtgca
     4441 ttggggtcat tgcggtctat cttgtactcg gccatgcccg caatctggtc attgtccgga
     4501 ttgccattgg caaagcggtc gggcatcagc aggtacagtg cgtcggaggc gtcgaaacct
     4561 ttatgttcgc aacctttctt gttgcgtgcc ttcagttcat attcctttac gagtttcttt
     4621 tttccttcag tgaaggtgag gttgaatttg ccgggtttta catccttgtc cagtttcaga
     4681 tagaccagga ggtagttgtt gctttccagc ttgacggtgc tgctcaatga gacgccggga
     4741 taattgacgg atactgccgc gttgccgatg ccttcgccat agaccatcag ctggagttcc
     4801 gggttctgca tgccggtgta ccaaaacgga gggtcgattt tgttcacatt catagctgca
     4861 tacgtactga gggagagtaa gagtgttccc aagattaaga atactttttt catgatagta
     4921 actttacggt taatttttgc gctaatttaa aacaaataac ggagaaagtt aatctttctc
     4981 cgttactgta ctttattata ttatgcaaac gttttcattg ggctatttga tgggggttac
     5041 gctggcggta tcgacctttc ccttgaagaa gtcctctttc ttgcgctttt ctctgatgtc
     5101 cttcagccag ttttcggcgg cattgtatcg gttgtcttct ccgatgatgg gaactccgtc
     5161 cgcatctact tcctgcactt tgtccttgct gtttttcgga cgggttttca ggtaggccgt
     5221 taggtatctc tctgctttgg acgcatcttt cagatagtaa taatagataa aggctgcgtc
     5281 gtagagcagt ttgtgtttct gccggtcgta tttttcgtat tgtgtcagaa gggtattcgc
     5341 ctggtcggtg tattgaaatg ccatcttgta gcagtccgca agccccacat ataggcggga
     5401 catgacactg tcgctgggca tggcgaggct tacggcagtt tccagataag tcactccatc
     5461 ctctttccat gatgtcttgg agcaggcgcg tcccagataa tagagaacgt tgatgttggt
     5521 attgtcatct ttaagagccc tttccagcag gtcgtgtgct gggtagaagt cttcgagggc
     5581 ataatagctg attccggcgt agaagcaggt ttggaaagaa ctgtcttttt cctgtaacag
     5641 ttgttcatat ctttctattg ctttggggta atctttgttc aggcaatagg cttgggcatt
     5701 gatgcggttc acaaggacgt tggtggagtc tatggaacgg tatttctccg ttatgtttat
     5761 ggcgtcttca tactggtggc ctgctacata gatgttgccg agtttggcag cagacaggta
     5821 atcattggga taccttttct gtatgtccag gtaggcatct atcacatgca tgatttctgt
     5881 gttgtcatag acttgcccca tactttcggc tctaaggtgt agtacatagg tggaactgtc
     5941 cctttctgcc agcaggttac tttcctttag agactcacgg tatctcttca tgttcatcag
     6001 cagactgata tactgaatgc gtgcgtattt attgtccgga tttatgtgga gcgcattctg
     6061 gtagtaatcc agtgcctcgc tatatttggc aagtgatttg cagcattcgg cagcttcaat
     6121 gtatgcccgg ggattgagag aatcctgagc tacgacttcc tgaaatacgc tcagagcttc
     6181 aaggttattg cccagccctt tcagcgcttt ccctttttgg tagagtaggg ggacggtcgg
     6241 ggtttcttga tcgatcagca tcaaggctgt ttcataatcg tagttggcca tcgcctcttg
     6301 aatgggattt gtggtctgtg ccgccagaag cgaacagcat gcactgaaac ataaggagat
     6361 aaaaagcttt cgcatacagt atatcattta tatgaggtta aactgactgc aagttactaa
     6421 aaagaatgta tttacgaaat aatcgtaatc tgttttagat agattaacga aaaagcccct
     6481 ccaaaaatga aggggctcta aaatagttca gaattcaagc cggataacgg aatgaataaa
     6541 tgtattacat taagaatccc agcaggatac ctgctgctac agcggaaccg attacaccgg
     6601 caacgttcgg gcccatagca tgcatcagca gatagttggt aggatcgtat tccagaccta
     6661 ctacttggga gatacgtgca gagtcgggta cggcagatac accggcatta ccgatcaacg
     6721 gattaatctt gttgcctttc ttcaggaaga ggttgaaaat cttcacgaag atgacaccgg
     6781 atgctgtggc aatgacaaat gataaggcgc ccagaccgaa tatcttgatt gaatcaaggg
     6841 ttaagaactc ggatgcttgc gtagaagcac ctactgtcaa accaagcaga atagtaatgg
     6901 tatcaatcag cggaccactg gctgtgtttg ccagacgacg tgtaactcca ctttctttca
     6961 gtaaattacc gaagaacagc atacccagca aaggcagacc ggatggtaca aggaatgtgg
     7021 ttagtaacaa accgataatc gggaacatta ctttttccgt atgtgaaacc acacggggag
     7081 gtttcatacg gataagacgt tcatttttac tggtcagcca acgcataata ggcggctgta
     7141 tcaccggtac taatgccata tatgaatagg ctgataccgc aatggcaccc attaagttag
     7201 gagccagttt ggaagagagg aagatggcag tcggaccatc ggcaccacca atgataccga
     7261 ttgcaccagc ctgcatcggg tcaaatccta tggcaagggc aatcatataa gcaccgaata
     7321 taccgaattg ggctgctgca ccaaccaaca ttaatttggg gttcgatatc aaagcggaga
     7381 aatccgtcat ggcaccgata cccaggaata tgagtggcgg gtaccaaccg gaggttactc
     7441 cctggtacag aatattaagt acggaacctt cttcatagat accgactttc aatccggctt
     7501 ccatattgaa aggtatatta ccaatcagca taccgaaacc gataggaatt aatagcatcg
     7561 gctcaaattc cttggctaca gccaagtata tgaaaaacaa acctaccaga agcattacca
     7621 catgtcctac cgttgcattg gcaaaacctg tataagtcca gaagtcggca aggttgtttc
     7681 ctaaaaatgt gataaattct cccatattat tcaataatta cgaggtcagt accttcgaga
     7741 acagagtccc ctttgtttac attgatggct gtaatcttac cgtctttatc agcattgata
     7801 ttgttttcca tcttcatggc ttccagaatg atgataactt gtcccttctt tactgtatcg
     7861 ccgacattta ctttgatatc gaggattaca ccgggaagcg gagattttac acctgacttg
     7921 ccggtagaag cagcggccgg ttttactacc ggagtagcag gagcagcagg agcggatgtg
     7981 gctgccggac gtgctaccgg tttaacgact accttcggtg ctttttccat ttcaactttg
     8041 tagggagtac cgttcacttc tacgtgagcg atgttgtctt caatatctcc aatggcaact
     8101 ttatatacgt taccgttaat tttatattta tattctttca tcgttttatt ttattatggg
     8161 tgacttactt tttgtgagga gtctcacgca acgtataaat ctttgaactc cacggtgagt
     8221 aactgcgttt tacacgggta atggtaagta tcgtgtcttc cacatcgtgt acatcgcttt
     8281 ggaattcgtg catggccatt gaaatggcag caaaaacttc tcccggagcc tgccccagtt
     8341 gtttctcttt tgcttcttgt ttatcagtaa tacctttagc tttcatggca ttgcgtttgc
     8401 tgaggttaac tgatatttta cctataatct tgaaggagat gtagagtaat atcagcccgc
     8461 agaatacaac gctcatggca gaaatagcca taccgatacc tacgctgtca tgctcttcga
     8521 atttttccat tttggcattg ctgtcgatag tcttgttgtt ggtactcgga gtgacatatt
     8581 tatcttcgct tccacccttt acttcccatt ggtcggctgc atcactgaca cgggcatagg
     8641 attggttggc ttttaaagta ccggcaggca ctatgacttg atcaagcaat ttcttgccgg
     8701 aatcatacaa cccaatccag ttggcatttg tggcatccag tttgaagttc gtatgaaatg
     8761 taccgcgtct tggttctcca tcagcccaga aaagtgcatg ctgacgtggt tttatgagtg
     8821 tcagaacgtc acctttggga atgaaataac tggcagtatc acccggctgg ctgctgaatt
     8881 tcagatagca acctgcaagg tcggcgctgc cgtatgatct gttgaatatt tcaatccatg
     8941 cgctgtgcac accgtagtca tcctgatagt tgctttcgtt gttgaccagc acttcattca
     9001 gcagcagttt gttgttcgat ttctgttctt tgcaagaaga gcaaaagccc aacaccagca
     9061 tcaatgaaag gaatattccg atttttgttt tattcataat cgttcttgtt ttagtgtgaa
     9121 aagcttgatt acaagggaat attaccatgc ttcttagccg ggttagtcaa tttcttggtt
     9181 tgcaactgtt gcagggcacg aatgatgcgg aaacgtgtgt tacgcggttc gataacatca
     9241 tcaatgtagc catatttagc tgcattataa ggattggcaa acaacttggt gtattcagcc
     9301 tctttttcag ccaggaattg agccggattt tcctgctctt tggcttcgcg ggcatataat
     9361 acttctacag cacctgcacc acccattaca gcgatttcag cagtaggcca agcataattc
     9421 atgtcgccac gcagctgctt acagctcatc acgatgtgcg aaccaccgta ggatttacgc
     9481 agtgtgatgg taaccttggg tacagtagct tcaccgtatg catacagcag tttggcaccg
     9541 tgcaggatga cgccgttgta ctcctggccg gttcccggaa ggaatcccgg tacgtctacc
     9601 aatgatacga taggaatatt gaaggcgtcg cagaaacgga cgaagcgtgc gcccttgcgg
     9661 gatgcgttgc tgtcgagcac acctgccaga tacttcggct ggttggcaac aatacctacg
     9721 gactgtccgt tgaaacgtgc gaaaccaata atgatattct ttgaataatc tttttggatt
     9781 tcgaggaact caccattatc tatgatagcg ccaattacct cgtacatatc gtacggtttg
     9841 ttcgggttat caggaatgat atcgttcagg gaatcttcca gacggtcaat agggtctgta
     9901 cagtctacat agggagcttc ttccagattg ttctggggaa tgtagctcaa cagtttgcgg
     9961 ataagggcca aaccttcttc ttctgtctgt gcagtaaaat gagtaacacc agatttggtg
    10021 gagtgaacgc tcgcgccacc caggttttcc tggcttacgt cttctccggt tacagtcttt
    10081 actaccttcg gaccggtaag gaacatgtag gatgtacctt ccatcatcaa agtaaagtct
    10141 gtcaaggcag gagagtaaac ggcgccaccg gcacaaggac cgaaaatacc ggaaatctgc
    10201 ggaatgacac ccgaagcaag tatgttacgt tggaagattt cagcgtagcc agccaaggca
    10261 ttaatacctt cctgaatacg tgcaccgccc gagtcgttga taccgataca cggagcaccc
    10321 attttcatgg cttggtccat aatcttacag attttcagag acatggtttc ggacagtgaa
    10381 ccggcagaaa ctgtgaagtc ctgtgcgaag atataaacca gacggccttc gattgtaccg
    10441 caaccggtta ctacaccgtc accggggtag tgtttctttt ccatgccgaa gttggtgcat
    10501 ctatgttcta cgaacatgtc catttcttcg aaactgcctt cgtcgagaag catggctatg
    10561 cgctcgcgag ctgtatattt acccttctcg tgttgctttg caatcgcttt ttcaccacca
    10621 ccgagacgtg ctgcagcgcg gcggtctata agctctttaa tcttttcaag ttgattactc
    10681 atgaatttat attctttaag tgtttataca atttatgatt tgatgatttt acagtcttgc
    10741 ttattccggt ttctcgcaaa gctcggtcag gacaccgaga gttgacttcg gatgcaggaa
    10801 tgcaatgttc agaccttctg cacctttgcg gggagctttg tctataaggc ggataccttt
    10861 ttcttcgact tcggcaagcg caccggccac tccgtcttca acggcgaatg cgagatgatg
    10921 catgccaccg ttaccgttgt tcttttcgat gaacttggca attgtgcttt cgggagaagt
    10981 aggttccaac aattcgatct ttacatcgcc cactttcagg aaagcggttc taactttctg
    11041 atcttccacg gtttcgatgt tgtagcattt caaacctaaa acgttttcgt agtacggaag
    11101 ggcttcttca atgctcttaa cggcaatgcc cagatgctca atgtgtgaaa tcttcataac
    11161 tatataaatt aatgttagta ttgtatcctt tttaataaag gtataaagca gcacaaagaa
    11221 agagaattct tccttaataa agaaattttt catcaattaa ttaatggtta attgaacttt
    11281 agaaggattt tttcagactt tagatagaga ccggttgttt tcttgatatc gtccgctaac
    11341 ggacatcccc actgtccgaa aatgaacact tacccctcta tgaaaccttt ccggccactt
    11401 ggcacactct ttgcttttct gtttgcgaca attttaaaga ttgaacatga aaaagaatat
    11461 tttacttgca gtttgttttt tgatgccgtt ggcaaccatg gcgcagaatg atactttggg
    11521 acatgaacgc aatattacgc tgtcggaggc cattgtactg gcccgtacgc agtctgtgga
    11581 tgctgctgtg gcattgaatg aattgaaaac cgcgtattgg gaataccgta cattccgtgc
    11641 ggacttgttg ccggaagtga atttcaccgg tacactaccc aactataaca agtcctacag
    11701 tacctaccag aattccgacg gctcctatag ctttgttcgc aacaatacac tggggctgtc
    11761 cggacagctt tcggtagacc agaacatttg gtttacgggg ggtaagctgt cactgacttc
    11821 ttcgctggat tatctcaaac aactgggttc cggaggagcg aagcagttca tgtcagtccc
    11881 cgtgagtctg gagttgacgc aaccggtctt cggagtgaat accttgaagt ggaaccgccg
    11941 tatagagccc gtacgctatg ccgaggcaaa ggccgagttc atttcagcta cggaagaggt
    12001 gacgatgaaa accatcactt atttctttga gttgctgctg gccaaagaat cgctcgctac
    12061 cgccatgcag aacaagacga atgccgaccg cctttatgaa gtggccatag ccaaacgtaa
    12121 aatgggacag atatccgaga atgatttgtt gcagcttaaa ctgaattcat tgcagggcaa
    12181 ggccgacgtg actgaggcag agagcaacct gaatgcaaaa atgttccagc tccgttcttt
    12241 cctcggggtg tccgagcagg aaagcctgaa tccggtgttg cccgccactg ttcccgatat
    12301 aaagatggag tatgaccgtg tgctgaacaa ggcactggaa cgcaactcct ttgcacagaa
    12361 cattcgccgc cgccagctcg aagctgatta tgaagtggca acggcacgcg gaaacttgcg
    12421 cagcatcgac ctctttgcca gtgtgggcta tacggggcag aaccatgaat tctcttcagc
    12481 ctaccgggac ttgcttgaca atcagattgt gcaggtaggc gtcaagattc ctatccttga
    12541 ctggggcaag cgccgcggca aggtaagggt ggcaaagagc aaccgtgaag tggtcttgtc
    12601 cagaatccgt caggaacaga tggactttaa ccaggacatc tttttgctgg tggctaactt
    12661 caacaaccag gcgcaacagc tggacatagc cgaagaggcg gatgtcattg ctgagaagcg
    12721 ttacaagact agtgtagaga cctttatgat aggtaaaatc agcaccctgg acctgaacga
    12781 tgcacagaac tctaaagacg aagcccgtca aaagcatatt tcagagctgt actactattg
    12841 gtattacttc tatcagctcc gcagcttgac cctttgggat tttgaacgcg atacggaatt
    12901 ggaagctgat tttgaagagg tggtaagagg ataagtcgac gggttgcaag tgataagtta
    12961 tgaattattt gccggtaaaa gtaccgtata tgcgatatta taggtaaata acttataact
    13021 tatcattcat aactctgctt ttttacttat ttttgcggga aacaaactac aatttttatg
    13081 atactgataa tagacgacga tagtgctgtg cgctcttccc tcagctttat gctgaagcgt
    13141 gccggatatg aggtgaaaac ggctccgggt cctcgcgaag ctatggatat agttagggcc
    13201 gaagctcccg ctttgatttt gatggatatg aacttcactc tttccactac cggagaagag
    13261 ggacttacct tattgaagca ggtaaaggtg ttccgtcccg atgtgcccgt tattttgatg
    13321 acggcatggg gaagtatcca gcttgccgtg cagggtatgc aggccggcgc attcgatttc
    13381 ataactaagc cttggaacaa tgctgctctt ttgcagcgca tcgagacggc ccttgagctt
    13441 acggccgccc cgaaagaggt gccggaagaa cagactaccg cattgaatcg cagctatatt
    13501 ataggtaagt ccaaagggtt gatggaagtg ttgaacacag tggcccgcat agcccgtacc
    13561 aatgcttcgg tgctgattac gggcgaaagc ggaacgggca aggagctgat tgccgaagcc
    13621 atccatatca acagccaacg cgtgaagcag ccctttgtca aggtgaacct tggtggcatc
    13681 tcgcagagct tgttcgagag cgagatgttc ggccataaga aaggggcgtt taccgatgcc
    13741 agcgccgacc gtatagggcg ttttgaaatg gcaaataaag gtactatctt cctcgacgag
    13801 attggtgacc tcgacccttc ctgccaggtg aaactgctgc gcgtgcttca agaccagaca
    13861 ttcgaagtgc tgggcgatag ccgtccccgc aaagtcgatg tacgcgttgt gtccgccact
    13921 aatgcagacc tccgcaagat ggtgtccgaa cgtactttcc gtgaagacct tttttaccgt
    13981 atcaacctga ttaccgtaaa actgccctcc ttgcgggagc gccgtgaaga tattcctttg
    14041 ctggcacgtc actttgccga ccgtcaggca gaggtgaacg gcttgccgcg tacggatttc
    14101 tcggccgacg ctctgaat
//
