LOCUS       gnlProkkaPEDDOBKN_73   12360 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PEDDOBKN_73.
ACCESSION   gnlProkkaPEDDOBKN_73
VERSION     gnlProkkaPEDDOBKN_73
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 09:16:34
            Original ID  :: gnl|Prokka|PEDDOBKN_73
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12360
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12360
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2147:2360]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2148..2360
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12360
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12360
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             53..442
                     /locus_tag="ctg73_1"
                     /transl_table=11
                     /translation="MYLLLVILMLIASVLMCFIVLIQNSKGGGLASGFSSSNQIMGVRK
                     TTDFLEKATWTLAAVMVVFSIVSAYTIPSSTGKGGDVILEQAQQEEKTNPYNMPVGTEA
                     PQSEAPAATTPAETPAPAAEAPAAE"
     CDS             656..1987
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 97.6; E-value: 9.9e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg73_2"
                     /transl_table=11
                     /translation="MIVAFTMMAAYYVNDVVAPLKTMLETDLAWSSTDFGFFTGGYSFL
                     NVFFLMLIWGGLILDRFGIRFTGKLATILMVGGTALEYYAMTGLAGADATLFGINEIFG
                     YKTGVFVAFAGYSIFGVGAEVAGITVSKIIAKWFKGKELATAMGVQVALARIGSQAGYA
                     VAIPLARAFGISTPVLLGLVLLLGGMIAFFIFAVMDKKLDKQMEAAAIAAGTEDEEEKF
                     SFKDVKNILVNPGFWLIALLCVLFYSCVFPFQKFASELMIIKYGINENVAGTFAGLPAL
                     GALILTPVFGGFIDKRGKSASIMLLGSAMLICVHFIYAIPDINYWLVAIVLMIILGIAF
                     SLVPSAMWPAVAKIFPVSQLGTAYALIFFIQNIGLWGIPTLIGWVLDAYCISGKKPDGT
                     NMYDYTVPMCIFTGIACLSLIVALLLKKADKKYGYKLEEPNIQK"
     CDS             2148..2360
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_3"
                     /sec_met_domain="PqqD_RRE (E-value: 2.5e-10, bitscore:
                     30.8, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.8e-17, bitscore: 54.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKGMSPDIHVRLEEHGTAVWNLIDGHRTVREIISLLARHFGEEE
                     NYIPRVTAYVMQLRKDGFIQLTIRN"
     CDS             complement(2368..2571)
                     /locus_tag="ctg73_4"
                     /transl_table=11
                     /translation="MDGVAYNLPGKAQVTLMYNNKKLFDDQLPITQFGTVEYLAPVLFN
                     KNSTIKVLFDTATGGLIKVDRE"
     CDS             2660..3121
                     /locus_tag="ctg73_5"
                     /transl_table=11
                     /translation="MATTPSFREKRKATSSFISLGVSRMVNVLGSFFILPENISVIAVS
                     CWFRLSSISLSWAPSLGILSASPRRRAFLLSRMLYISLATSSAILALELDISISSVRKL
                     RGSMLLSVALASGVLAAGLPLNGMLMERTIPSSVSSIRGATVLSFIFTK"
     CDS             3259..3393
                     /locus_tag="ctg73_6"
                     /transl_table=11
                     /translation="MFGGLQYDFYFCFGQHISHSVVFVTHHTGGYVCLRHGSDRQEQS"
     CDS             complement(3488..4615)
                     /locus_tag="ctg73_7"
                     /transl_table=11
                     /translation="MKTLLFCMLGLGLTACGSSPKGTNGDQDELAMLIGTYTNGSSKGI
                     YTFRFNQETGTAVPLSSAALPNPSYLVPSGDGEFVYAVSEMNDSTAALSSLSLDRETGE
                     LRLLNTVPTFGADPCYVATNGREVLTANYSGGTMSVFPLQKDGTLAPADTLFQGSATGP
                     DAIRQATPHIHCTVFSPDGKYIFATDFSADRILRFVMHPDDPIPHASLEAVDIEADSGP
                     RHLTFSPNGKFAYLITELSGKVIAFSYDDGRLEQIQTITADTVAARGSADIHLSPDGKY
                     LYASNRLKEDGIAIFAVNPENGTLAKVGYQPTGIHPRNFNITPNGKYLLAACRDSNVIQ
                     VYKRNEVTGLLEDTHQDIVVDMPVCVQFVSSVNNL"
     CDS             complement(4717..7689)
                     /locus_tag="ctg73_8"
                     /transl_table=11
                     /translation="MEDIFSKRKTLRTIKADTSDYFIPLFHTLAVFLSTKETIITKRFL
                     EHIMKNLIALTLLLGGSTLLCAQKPAKTPATYKPVKSEMYRKGWIDFNKNGVKDVYEDP
                     SAPLEARIENLLQQMTLDEKTCQMVTLYGYKRVLKDDLPTPEWKELLWKDGIGAIDEHL
                     NGFQQWGLPPSDNAYVWPASRHAWALNEVQRFFVEDTRLGIPVDFTNEGIRGVESYRAT
                     NFPTQLGLGHTWNRELIRQVGLITGREARMLGYTNVYAPILDVGRDQRWGRYEEVYGES
                     PYLVAELGIEMVRGLQHNHQVAATGKHFAAYSNNKGAREGMARVDPQMSPREVENIHIY
                     PFKRVIREAGMLGVMSSYNDYDGIPVQGSYYWLTTRLRGEMGFRGYVVSDSDAVEYLYT
                     KHGTAKDMKEAVRQSVEAGLNVRCTFRSPDSFVLPLRELVKEGGLSEEVINDRVRDILR
                     VKFLIGLFDAPYQTDLAGADREVEKEENEAIALQASHESVVLLKNADELLPLDINSTKK
                     IAVCGPNANEEGYALTHYGPLAVEVTTVLEGIQEKTKSKAEVLYTKGCDLVDAHWPESE
                     IIDYPLTDDEQAEIDKAVENARQADVAVVVLGGGQRTCGENKSRTSLDLPGRQLQLLQA
                     IQATGKPVVLILINGRPLSINWADKFVPAILEAWYPGSKGGTALADILFGDYNPGGKLT
                     VTFPKTVGQIPFNFPCKPSSQIDGGKNPGPTGNMSRINGALYPFGYGLSYTTFEYSDLD
                     ITPRVITPNESATVRLKVTNTGKRAGDEVVQLYIRDVLSSITTYEKNLAGFQRIHLEPG
                     EAQELSFTIDRKHLELLDADMKWVVEPGDFVLMAGASSEDIRLNGTLTVEDYQTRAKAI
                     EAQKPAKRVSASTNPEDAENVLDEKINTAWQGNKGDYITFALKNGAKVDKVAIAFTRDN
                     NLPATFEIQLSGGGGQFLTVYSGTVSEYGKLISYPFKGTTASDLRIVLNDDRVSIAEVK
                     F"
     CDS             7860..8000
                     /locus_tag="ctg73_9"
                     /transl_table=11
                     /translation="MLLVRKNFLFNLGMSKPNLGLDIPRLGMEKPKFGIDCFLNSFRFF
                     S"
     CDS             9002..9451
                     /locus_tag="ctg73_10"
                     /transl_table=11
                     /translation="MKERERIGNRLAILRKKRNMTQEELANLCGVNRVNIAKIEKGAYN
                     VSIDILSKVTSALGFVIDIKVDSSVCPTHFSQRKPVKLVIGEDYYVSFGNNEAHRCKLV
                     DIPEMYQGQRIKIETPTPRGSITHILFADEIGTTPDEAVMNQVTM"
     CDS             complement(9651..10481)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 57.4; E-value:
                     2.6e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg73_11"
                     /transl_table=11
                     /translation="MDNQTQEGTKNMQKRHTDRESYFDEQSQTSKNYYIPYIKEVIGHI
                     PDKVLEVGCGEGGNLLPFAEAGCRVMGVDIDATRIEQARTFFAQRHQQGQFIATDIFQL
                     KDKATNFPLILLHDVIEHIRDKERFFSGLQEHLSADGAVFVGFPAWQMPFGGHQQIAHS
                     HIVSHFPFLHLLPRTLYRWILRLCGEQERVIMELLDIKSTGCTIELFNRIARQANYQII
                     DRRLYLINPHYKIKFGLSPRRLNGVIAAIPYIRNFFCTSCFYILKKGTKTVNHY"
     CDS             complement(10530..12119)
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 65.8;
                     E-value: 6.6e-20)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg73_12"
                     /transl_table=11
                     /translation="MSLLYENYSEKMLKVCLRYIPDPTIAQDLLHDGFVIIFTSIHSLR
                     NPEKLEYWMKKIMRNLALQYLNHANANPTIPLTDIPEEEEPAENPFCPDFISYDKMLDI
                     VESLPEGYCKVFKLAVLEGLSHKEIGDLLGIAPHSSSSQLFRAKILLKKMLAGYRVFIV
                     LTVLLLFPTLYDYLYREKKSIRENRLSKVSSRQAGSTQQTKKTDTPRTDEQCYTKENLN
                     KRERIIPPVPVSTEWPLAIPTMKDSIHKYPIPSPFTGQTITNRQMAFVFSPSLMPPTRK
                     KKSGKWKLMLAGSLGPQLAQNLYKLIATPHTDGISSDFPQQVSTWEEYYSYLHTRYQQG
                     TLGKDSIGLMQIAQNNSGRIVENQQHHAPIVVGLSLSKKLNERWSLETGLQYTLLRSEF
                     TTGEAFRIQDNQKLHYIGIPLRLSYCFWHYKRFSGYATAGMQVDIPIKGTLQSFHVTDS
                     IPHKLDSQPVSAPWQWSVNTSIGIQYRLTPQAGIYLEPTVNYYIPDGSQLRTIRKEHPF
                     IFTLPVGLRISW"
ORIGIN
        1 caaatcagat ttttggagaa attgattatt aacgctaaat caaaataaca aaatgtattt
       61 attattagtt atcttaatgc tgattgcatc tgtgctgatg tgcttcattg tattgattca
      121 aaattctaaa ggaggcggtc tggcatcagg cttttcatca tccaaccaaa ttatgggtgt
      181 gcgcaagact acggactttt tggaaaaagc aacctggact ctggcagctg tcatggtagt
      241 cttcagtatt gtttctgctt acactattcc ttcttccaca ggcaagggcg gtgatgtgat
      301 tctggaacag gcgcaacaag aagaaaaaac taatccttat aacatgcccg taggtacaga
      361 agctccgcaa tcggaggccc ctgcagctac aactccggct gaaactcctg ctcctgcagc
      421 agaagcccct gcagcagaat aagataagga tattgcggat gactcccgct tggaaaaata
      481 agagaaaggt tgatactgaa aaggtgtcag ccttttttcg ttttgatgaa gtatttattt
      541 acctttgtca gcaatttatg caatctgatt aataaattga aatccaaata gtacaatgac
      601 agaacaactc aaacttaaat tgaatgattc caaggctacc cgttgggggg cattggtgat
      661 tgttgccttc acgatgatgg cagcttatta tgtaaacgac gtggtagcac cgttgaagac
      721 aatgttggaa acggacttgg cttggtcgag taccgatttc ggattcttta ccggtggtta
      781 tagttttctg aatgtttttt tcctgatgtt gatttgggga ggattaatcc tcgaccgctt
      841 tggtatccgt ttcaccggaa agctggcaac tatcctgatg gtaggtggta cagcacttga
      901 atactatgca atgacgggac ttgccggtgc cgacgcgact ttattcggaa tcaatgaaat
      961 atttggctat aaaacgggtg tgtttgttgc ttttgccggt tattccattt ttggagtagg
     1021 agcggaggtc gccggtatta cagtttccaa aatcatagcc aagtggttta aggggaaaga
     1081 gcttgccacg gctatggggg tacaagtcgc tttagcacgt atcggttcgc aagccggtta
     1141 tgccgtagcc attcctttgg cccgcgcttt cggtatttcc acaccggtgt tgttgggttt
     1201 ggttctgttg ttgggcggta tgattgcttt cttcatcttt gcagtgatgg acaagaagct
     1261 ggacaaacag atggaagctg ctgccattgc tgccggtacg gaagatgagg aagagaagtt
     1321 ctcttttaag gatgtgaaga atattctggt caatcccggt ttctggctga tagcattgct
     1381 gtgtgtattg ttctactctt gtgtattccc attccagaag tttgcttccg agttgatgat
     1441 tatcaaatac ggtatcaatg agaatgtggc cggtacattt gccggacttc cggcattggg
     1501 agcgctgatt ctgactccgg tctttggtgg tttcattgac aagcggggca agtccgcatc
     1561 tatcatgctg ctgggctcgg ccatgctgat atgtgtgcat ttcatttatg ctattcccga
     1621 tataaactat tggctggtag ctattgtgct gatgataatt ttgggtatcg ctttctcgct
     1681 ggtaccttct gccatgtggc cggctgtggc caagatattc ccggtaagcc agttgggtac
     1741 ggcatacgca ttgattttct ttatccagaa tatcggtctt tggggtattc ctacattgat
     1801 agggtgggtg cttgatgcct attgtatatc cggcaagaaa ccagatggaa cgaatatgta
     1861 tgactatacg gtgcctatgt gcatttttac cggtattgcc tgcttgtccc ttatagtggc
     1921 tctactgctg aagaaggcag acaagaagta tggttataag ctggaagagc ctaatattca
     1981 gaaataatag gaaaagcgga taccgtatga tggaaatacc cgaaggaaaa gtaagtctgt
     2041 tggacgctgt tccggtccgc tgtggacata taacaaccga atgggaaggt gagtgcgccg
     2101 tactcgccta cccacggttt aaatacgaat ggatgcgtcg ttttttattg ccgaagggga
     2161 tgtctcctga catccatgtg aggctggaag aacacggtac agctgtctgg aatctgatag
     2221 atggacatcg taccgtgcgc gaaatcatct ctctacttgc caggcacttt ggggaggaag
     2281 agaattatat tccccgggtc accgcctacg taatgcagtt gcgtaaggat ggatttatcc
     2341 agttgacaat ccggaattag aattccttta ttccctatcc acttttatca atcctcccgt
     2401 tgccgtatca aacagcactt tgatggtaga attcttgttg aacagtaccg gtgcgaggta
     2461 ttctacggtg ccgaattggg taatgggaag ttggtcgtca aacaatttct tattgttata
     2521 catcaatgtc acttgtgcct tgcccggaag gttataggct acaccgtcca ctttcttttt
     2581 gccttcctcg gtggcagata catcgggact tttgaggtcg gtgacgctga tataatacgg
     2641 ttcaccggca aggtcattat tggccaccac tcccagcttt cgggaaaaac ggaaagccac
     2701 ctcatctttc atctctttag gcgtcagccg gatggtgaat gtcttgggtt ctttctttat
     2761 tttgcccgag aacatttccg tcatagccgt ttcctgctgg ttcagattgt caagcatcag
     2821 cttgagttgg gcgccgtcct tgggcatatt gtctgcttcg ccgcgcagga gggcattctt
     2881 gctttcgcgg atgctgtata tttccttggc caccagctcg gccatcttgg cactggagtt
     2941 ggacatcagt atttcttccg tcagaaaact gcgtgggtca atgttgcttt cggtggcttt
     3001 ggcttcgggc gtcttggcag caggcttgcc gctgaacgga atgttgatgg agcggacaat
     3061 tccgtcttcg gtaagctcca taaggggtgc tacggtcttg tctttcatct tcacgaaata
     3121 gacgttgtcc ttatccggta caccggctat gcgggtttct atcttatcca gtgtccagaa
     3181 ctcctcgggt tcggcagaca cgttgttgag acgcagatag cggtcggcat atctgcaaaa
     3241 ttctccggga gtgtaagtat gtttggtggc ttgcaatacg atttctattt ctgttttggg
     3301 caacatataa gtcactccgt agtctttgtc acgcatcaca ccggtggtta cgtctgtttg
     3361 cgccatggca gtgatagaca agaacagagc tgagagcatc aatatattct tcttcataat
     3421 gtacattcgt ttagactgat ttagctaagg gacaaagtta atgaagttat ctttgctaaa
     3481 tattgcttta taaattatta acagagctga cgaactgtac gcaaaccggc atgtcgacta
     3541 caatgtcctg atgagtatct tccaagagtc cggtaacttc gtttcgtttg tatacctgaa
     3601 tgacattgct gtcgcggcag gcggcaagca agtatttacc gttgggcgtg atgttgaagt
     3661 tgcggggatg gatgccggtg ggctgataac ctacctttgc caaggtccca ttttcgggat
     3721 tcacggcaaa gatggcgatg ccgtcttctt tcagacggtt gctggcgtag aggtatttcc
     3781 catccggact gaggtggatg tctgcacttc cacgggcggc tacggtgtcg gctgtgatag
     3841 tctgtatctg ttccaggcgg ccgtcgtcgt aactgaaggc aatgacctta ccggacagtt
     3901 cggtgatgag ataggcaaac ttcccgttag ggctgaatgt cagatggcgc gggccggaat
     3961 ccgcttcaat gtcaacggct tccagagaag catgaggaat agggtcgtcg gggtgcatca
     4021 caaagcgcag gatgcggtcg gcactgaagt cggtggcgaa gatatacttt ccgtccggtg
     4081 aaaagaccgt gcaatggatg tggggagtgg cttgccgtat ggcgtcggga ccggtggcag
     4141 agccttgaaa gagcgtgtct gcaggagcca aagtaccgtc tttctgtaaa ggaaagacgg
     4201 acatggttcc accgctgtag ttggcagtca acacttcccg gccattggtg gccacgtagc
     4261 aggggtcggc gccgaaggtg ggaacggtgt tcagcaggcg cagttctccc gtttcccggt
     4321 ctaaggaaag ggagctgagg gctgctgtgc tgtcgttcat ttcactgacg gcatagacaa
     4381 attcgccatc tcccgagggt acgaggtagg agggattggg caatgccgct gaactgagcg
     4441 gaacggctgt tcccgtctcc tgattaaagc ggaaggtata gatacccttg cttgagccat
     4501 tcgtgtaagt acctattagc atggcgagtt cgtcctggtc accgttagtg ccctttggag
     4561 aagagccaca tgctgtcaaa cctaatccga gcatacagaa aagaagtgtt ttcattaatt
     4621 taatgtgtta atgtgccaat atgctaatgt gctaattggc tgcgctgtat atgctgcatg
     4681 gtcattggta cattagcata ttggcacatt agcacattaa aatttaactt cggcaatact
     4741 gacgcggtca tcgttcagca cgatgcggag gtcgctggcg gtagtgcctt tgaacggata
     4801 ggaaatcagt ttgccgtatt cgctgacggt gcccgaatat acggtgagga actgtccgcc
     4861 accgcccgag agctggattt cgaaggttgc cggcaggttg ttgtcacgtg taaaggcaat
     4921 ggcaacttta tctaccttgg ctccgttctt caaggcaaag gtaatataat ctcccttatt
     4981 tccttgccat gcggtattga ttttttcgtc aagcacgttt tcggcatcct ctgggttggt
     5041 gctggcactc acacgctttg ctggtttttg ggcttcaatg gctttggcac gggtctggta
     5101 gtcttctacg gtcagcgttc cgttcaggcg gatgtcttcg gaagaggcgc cggccatgag
     5161 tacgaagtcg ccgggttcca ccacccattt catgtcggcg tccagaagct ccaggtgctt
     5221 gcggtcgatg gtgaaggaca gctcctgggc ttcgcccggt tcgaggtgga tgcgctggaa
     5281 gcctgcaaga ttcttttcgt aggtggtgat gctgctcagt acgtcgcgga tatagagctg
     5341 cactacttca tctccggcac gtttgccggt gttggtcacc ttcaggcgga cggtggcaga
     5401 ctcgttcggg gtgatgactc ggggggtgat gtcgaggtcg gagtactcga aggtggtgta
     5461 gctcaagccg taaccgaagg ggtagagtgc tccgttgatg cgtgacatgt tgcccgtagg
     5521 tcccggattc ttaccgccgt ctatctgtga agaaggtttg caggggaagt tgaaggggat
     5581 ttgccctacg gtcttgggga aggtcaccgt cagctttcca ccggggttgt agtcgccgaa
     5641 gaggatgtcg gccagggctg ttccgccttt ggagccggga taccaggctt cgaggatagc
     5701 ggggacgaac ttgtctgccc agttgatgga gagcgggcgt ccgttgatga gtatcagtac
     5761 gacgggcttg cccgtggctt gtatggcttg aagcagttgc aactgccggc cgggcaggtc
     5821 gaggctggtg cgcgatttgt tttcgccgca ggtgcgttgt ccgccgccca atactacgac
     5881 ggcaacatca gcttggcggg cattttctac ggctttgtct atctcggctt gctcgtcgtc
     5941 ggtcagagga tagtctatga tttcactttc gggccagtgg gcatccacta ggtcgcagcc
     6001 tttggtgtag agcacctctg ccttgctttt tgtcttttct tgaatgcctt ccagtacagt
     6061 ggtcacttct acggcaagtg ggccgtaatg ggtcagcgcg tagccttctt cattggcatt
     6121 gggaccacag acggcaatct tcttggtgga gttgatgtct aagggcaaca gctcatcggc
     6181 attcttcagc agaacgacgg actcgtggga tgcctgcaag gcgatggctt cgttctcttc
     6241 tttttccact tcacggtcgg caccggcaag gtctgtctgg tagggggcat cgaacagacc
     6301 aatgaggaac tttacccgga ggatgtcgcg cacacggtcg ttaatgactt cttcgctcag
     6361 cccgccttcc ttcaccagtt cgcggagggg aaggacgaag gagtcgggcg agcggaaggt
     6421 acagcgtacg ttcagcccgg cttccacgct ttggcggacg gcttctttca tgtctttggc
     6481 ggtgccgtgc ttggtgtaga ggtattctac ggcgtcactg tcggatacga cgtagccacg
     6541 gaatcccatt tcgccacgca ggcgggtggt gagccagtag tagctgccct gcacggggat
     6601 gccgtcgtaa tcgttgtacg aactcattac gcccagcatg ccagcttccc ggatgacgcg
     6661 tttgaagggg tagatgtgta tgttctccac ttcgcgcggc gacatttgcg ggtccacgcg
     6721 tgccatgcct tcgcgggcgc ctttgttgtt actgtaagcg gcaaagtgct tgccggtggc
     6781 ggccacttgg tggttgtgct gcaagccgcg caccatttcg atgcccagtt cggctacgag
     6841 gtagggagat tcgccgtaaa cttcttcgta gcgtccccag cgctggtcgc gtcctacgtc
     6901 gaggatgggg gcgtagacgt tggtgtagcc cagcatgcgg gcttcgcgtc cggtgatgag
     6961 tcctacttgg cgaatcagtt cacggttcca ggtatgtccc agtcccagtt gggtggggaa
     7021 gttggtggcg cggtagcttt ccacgccgcg tatgccttcg ttggtaaagt ctacggggat
     7081 gccgagacgg gtatcttcca caaagaaccg ttgcacctcg ttcagtgccc aggcgtggcg
     7141 cgaggcgggc cagacgtagg cattgtccga gggaggcagc ccccattgct ggaagccgtt
     7201 caggtgttcg tcgatggcgc cgatgccgtc tttccagagc agctctttcc attcgggggt
     7261 ggggaggtcg tctttcagta cgcgtttgta gccgtagagg gtgaccattt ggcaggtctt
     7321 ttcgtccagc gtcatctgtt gcagcaggtt ttcgatgcgt gcttcgagcg gggcggaggg
     7381 gtcttcgtac acgtctttca ctccgttttt gttgaagtct atccaacctt tgcggtacat
     7441 ttcacttttc accggcttgt aggttgccgg tgttttggca ggcttttgtg cgcagagcag
     7501 tgtgcttcct ccaagcagca gggttagggc aataaggttc ttcatgatat gttctaaaaa
     7561 tctcttggtt attattgttt cttttgttga caaaaatacg gctaatgtgt gaaataaagg
     7621 gataaaatag tccgaagtat cggcttttat tgtccgaagg gtcttcctct tactaaaaat
     7681 atcctccaag acgctaccgg ggaattcaaa tcattattag acgaaacata tcattcactt
     7741 ttaaaaagaa agaacactat aataacctga aaagtagatg caatcgcggt gtatacaagt
     7801 attacggcta catctgttaa acgagggtgt atttatataa taggaatctg ttggcggaat
     7861 tgttgcttgt acggaagaac tttcttttca accttgggat gtctaaaccc aaccttggtt
     7921 tagacatccc aaggttgggt atggaaaaac caaagtttgg gatagattgc ttccttaatt
     7981 ctttccggtt tttcagttaa cttcagagac tttttccgtt aacttcccat ctcttttgtg
     8041 caaatatcca ttacagaaga tagatattcc ctcttgcagg gggtaattcc gtcaacggat
     8101 actggctttg gtagctgttt gaacattgat gacaatgggg tgcacatatt ctatgtatgg
     8161 aagattattg tttttatcac gaaaagtcag tattagctaa tatttgtaaa tatatggtga
     8221 ttgctaataa aagaatatgt atctttgggc caaagaaagc ggtagaggat gaaaaataaa
     8281 gtagcattta tccctttttc accctcccta cttagcaatg agttacgcaa tcttttaaat
     8341 ttcagaccgt tacaaagtca tggggttgac tggatttgac agcgggcaga aatggtaagt
     8401 aagcatgcag tgcgtcgttg atttgcactt taatctcagt cctcaaaatt ttatctggcg
     8461 aaactcgtta cgctctcgct gcttaatcga agtatagtag attgaagctt aatcccggca
     8521 ccaggtgctg ggacgtgaca tcactcggaa gctgttgctc cgaagcattc cgataaagtg
     8581 gtgcagtcaa atcggggata gttcgtgtca gcctcgtggc gcgggtgaaa atttagagga
     8641 taaggcaacg gttgatggct ttggttctgc cgctgcacga aaatttaggc aaagataagc
     8701 atgtagaaag cttatgattt cctcgtttgg acgagggttc gattccctcc agctccacgg
     8761 aaatagtaaa aagaagtttg taagtccttg aattccagta attcaggggc tttttctttt
     8821 cttctactcc ccctaccttt tatattcatt tagaaaacag ttgtagtaaa tgtgctacaa
     8881 ttcaaaatta atatctactt ttgtctgttc aaaaaccaat aactattaga agtgggggca
     8941 acactttaaa ttctgcaaca gatttatgaa aattcacgaa ggaaaatgta cagagaagat
     9001 tttgaaagaa cgtgaacgga ttggtaaccg gttagccatt cttcgcaaga agagaaatat
     9061 gacccaagag gaattggcta atctttgtgg cgttaatcgt gttaatatag ccaagataga
     9121 gaaaggggct tataatgtga gcattgatat actatctaag gtaacatccg ctcttggttt
     9181 tgtgatagat ataaaagtgg atagctctgt ttgtccgact catttctctc aacgtaaacc
     9241 tgtaaagctg gtaatagggg aagattatta tgtcagtttt ggcaataacg aagcccatag
     9301 atgtaagctg gtggatattc cggagatgta ccaaggtcaa agaattaaaa tcgaaactcc
     9361 gaccccgaga gggtctatca cccacatatt atttgccgat gaaataggaa cgacacctga
     9421 cgaggctgta atgaaccaag taacgatgta aaaacattaa aagggaggaa gtgcaagttc
     9481 cccttttatt gaaatcacct tcgctacaac catctgcagc gagggtgatt ttttagttta
     9541 tgagggtttc tacacaccct ctttcatcag ggctattcag aaatttaatg gtttcttctg
     9601 aatatataat cttaaattga tggttcggaa tcaattctaa agctgggaaa tcagtagtga
     9661 ttaacagttt tagtcccttt ctttaatatg taaaagcaac ttgtacaaaa gaagtttctt
     9721 atgtacggga tagcagcaat aactccgttg agccttcgtg gggacaagcc gaatttgatt
     9781 ttataatgtg ggtttataag gtacagtctc cggtcaatga tttgatagtt ggcttgccgg
     9841 gcgatgcgat tgaacagttc gatggtgcat ccggtgctct ttatatccag tagctccatg
     9901 attacgcgtt cctgctcacc gcatagtctt aatatccatc tgtataaagt gcggggaagg
     9961 aggtggagaa aagggaaatg tgaaacaatg tggctgtgtg ctatctgctg gtggcctccg
    10021 aatggcattt gccaggcggg aaaccctaca aatacagctc cgtcggcaga caaatgttct
    10081 tgtaggccgg agaagaaccg ttctttgtct ctgatatgct ctatcacatc gtgtagaaga
    10141 atcaggggaa aattcgtagc cttgtccttg agctggaaaa tgtcggtggc aatgaactgt
    10201 ccctgctgat gcctttgggc gaagaaggtt ctggcttgtt ctattcgcgt ggcatcaatg
    10261 tctacgccca tcacccggca accggcttcg gcaaagggga gcagattgcc tccctctcca
    10321 cagcccactt ccagcacttt atcggggatg tgtccgatga cttcctttat gtaggggata
    10381 taatagttct tgctggtctg tgactgttca tcaaagtagc tttcccggtc ggtatgtcgt
    10441 ttctgcatgt tctttgttcc ttcttgagtt tgattatcca tataaataga taatcagtcg
    10501 ggtaaaagac tgcgtggcgc atcgtttttt taccaggaaa tgcggaggcc taccgggagg
    10561 gtgaatatga acgggtgttc ctttcggatg gtgcgcagtt ggctgccgtc ggggatataa
    10621 tagtttacag tcggctccag atagatgcct gcctggggtg tgaggcgata ttgtatgcct
    10681 atacttgtgt tgaccgacca ctgccaggga gcacttaccg gctggctgtc gagcttgtgt
    10741 ggaatactgt ctgtgacatg gaagctttgg agtgtccctt ttatggggat atccacctgc
    10801 atgcctgccg tggcataacc ggagaaacgt ttgtaatgcc agaaacagta ggaaagccgg
    10861 agaggaatgc cgatataatg caacttctgg ttgtcttgaa tgcggaatgc ttcgccggta
    10921 gtgaactccg acctgagaag cgtatattgc aatccggttt ccagactcca acgctcattc
    10981 aatttcttgc tgagagagag tcccacaacg atgggggcat gatgttgctg gttctcaaca
    11041 atcctgccgc tgttattctg ggcaatctgc atgagtccga tggaatcttt tcccagagta
    11101 ccctgctgat agcgggtgtg cagataagaa taatactctt cccacgtgct gacttgttga
    11161 gggaagtcac ttgaaatgcc gtcggtatgt ggagtggcaa tcagcttata taagttctgt
    11221 gccagttgcg gtccgagtga acctgccagc atcaacttcc attttccgga tttcttcttg
    11281 cgggttggcg gcatcaggga aggggagaag acgaaagcca tctgtcggtt ggtgatggtc
    11341 tgtccggtga atggagaagg tatgggatat ttgtggatac tatctttcat tgtgggtatg
    11401 gcaaggggcc attctgtgga aactggaacg ggagggatga ttcgttccct tttgttcaga
    11461 ttttctttgg tatagcattg ttcgtcggtt cggggagtat cggttttctt tgtttgttgc
    11521 gtactcccgg cttgcctgga agaaactttg gacaaacggt tttccctgat actctttttc
    11581 tctctgtaca gatagtcata cagcgttgga aagagaagca atactgtcaa aacaatgaat
    11641 acacggtatc ctgccagcat ctttttaagt aaaattttcg cccggaacaa ttgggaggaa
    11701 gaggagtgtg gcgctatacc cagtaaatct ccgatttctt tgtgggacaa tccttccagt
    11761 actgccagtt taaatacctt gcagtagccc tccggaaggc tctccactat atccagcatc
    11821 ttatcgtacg aaatgaaatc cggacaaaaa ggattttcag caggctcttc ctcttccgga
    11881 atatctgtca atgggatggt ggggttggca ttggcatggt tgaggtattg cagtgccagg
    11941 tttctcataa tctttttcat ccagtattcc agtttctccg ggttgcgcag cgaatgaatg
    12001 gaagtgaata tgatgacaaa accgtcgtga agaagatctt gggctatcgt tgggtcggga
    12061 atatagcgta ggcatacttt cagcattttc tctgaatagt tttcgtagag caggctcaag
    12121 gcctgcccgt ttcccttctg gcataaagtg acaagagctt ttgtatccat gtgtttgtct
    12181 caatgttatt tcttaaggat agagaagaac atgaatgact gcatggattt ttatttttta
    12241 actaagcctc ccggttgact tctgctgcac agtccggaca aatgcctttc agtacatagt
    12301 tgatgctgtt cagtgtaaat ccttgaggca gcttcaccac cggagtggga atgttggtga
//
