LOCUS       c00068_gnlPro..        12953 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IKHIPLLC_68.
ACCESSION   c00068_gnlPro..
VERSION     c00068_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 13:28:22
            Original ID  :: gnl|Prokka|IKHIPLLC_68
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12953
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12953
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[304:3785]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      305..3785
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..12953
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12953
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(305..1072)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_1"
                     /sec_met_domain="Fer2_3 (E-value: 5.3e-24, bitscore: 74.4,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 2.5e-09, bitscore: 27.6,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.5e-05, bitscore: 14.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTLNLTLKVWRQENREAKGRIETYAAKDIPVDASFLEMLDIVN
                     EGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPERQVTTCQLHMRKFKDGDTVWIE
                     PFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAPNANNIAVEKVKADAAFDAAAC
                     IGWGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSKRVLAMMKQMEAEGFGNCTNQY
                     ECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
     CDS             complement(1113..3062)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 167.4; E-value:
                     1.8e-51)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_2"
                     /sec_met_domain="FAD_binding_2 (E-value: 4.4e-52, bitscore:
                     167.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 2.8e-38,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRTFYA
                     RGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEIKSY
                     AGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVKGDY
                     QSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFGNLA
                     PRDISSRAAKEACDDGRGVAITGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEITDD
                     DPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQGLS
                     DGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFHREL
                     GLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVADFLE
                     FAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLHKEP
                     LTFENVHLAIRSYK"
     CDS             complement(3084..3785)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_3"
                     /sec_met_domain="SucD_FumR (E-value: 6.2e-14, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             3986..4258
                     /locus_tag="ctg68_4"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             4291..5076
                     /locus_tag="ctg68_5"
                     /transl_table=11
                     /translation="MVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSADGFRDYFVQLT
                     ECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLGIGEIGLNRNT
                     SHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLDPCRVLVDHCE
                     EHTFPLVKEAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADWGDSDPLALTA
                     LACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(5110..5343)
                     /locus_tag="ctg68_6"
                     /transl_table=11
                     /translation="MNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPD
                     EFLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(5775..6482)
                     /locus_tag="ctg68_7"
                     /transl_table=11
                     /translation="MNKLLSTLILSAGMSLSATAATALLDSSIVGYSDFASQTADFGTR
                     KDSVSITSDDSNLTLSGITFNGYGANNRDVMSVTMVLDLSKINTPETYTALFNAKNSSV
                     SWGVGLNTDRKLQGLWNNTSYNGPVVDTPLGTEGSLTISVVTGDLGTRIYFGDSATYYS
                     NSGLKFGNQQIDQILMDAGLAESIEQLYIHDSLLSQEQVGQLMSEIASIPEPATASLGL
                     LGLAALMMRRRRA"
     CDS             6777..7517
                     /locus_tag="ctg68_8"
                     /transl_table=11
                     /translation="MKKTLTFLIAMGSFAVSSEAATVFNYYTPGTDNYNSTIHGFYLGL
                     GSSSLAPSDSSSPSSLSGEIRLDSFTLRGAANNLGANVTYGFLVLNGSDNSVIGWSTNT
                     GTTAAGINLTFSFSSLDGSPLLLDAALTYRFLAVSQSVMDLMQDTSKTYLYAAGGTAAP
                     TANTEGDTVTISGGLTAPGIRGHYDAEGAPGDSVVITGANGTNTFSLLSPIFTEIRGEM
                     VPEPATVSLGLLGLAALMMRRRRA"
     CDS             complement(7735..7869)
                     /locus_tag="ctg68_9"
                     /transl_table=11
                     /translation="MYAAALQVCELQRGSLSGLKGHYVKAAVYHMDEKRAAEFDGIFR"
     CDS             complement(7981..8181)
                     /locus_tag="ctg68_10"
                     /transl_table=11
                     /translation="MTIALRTEQSSDHAETEHVTREAFWNYFVPGCHEHYLLHIMRVSP
                     SFIPELDAVAVHGSRIVGKHR"
     CDS             complement(8195..9400)
                     /locus_tag="ctg68_11"
                     /transl_table=11
                     /translation="MRGIFLVSCFLGGSALLAGCREENNSPRPATEDAARITSARQWGE
                     SRSALQKRELDRAAGPALPIPDDLPSRELVGTTRQIHQLIEASGNPARFESYTETVPVA
                     GASLRMVAIPGGTFLMGSPAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENG
                     RPRAKDGQLLEEQPDDELWDSVTQPTAPYTAMNLGMGHGYEHGLPAISMSHHAASKFCE
                     WLSAQTGHYYRLPTEAEWEYACRAGSPGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSK
                     KPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPAKDPLVIIPGAPHIVRGGSWEDDPD
                     SLRSAARRASTPAWSRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDIMTMHRLWNFSKG
                     EP"
     CDS             complement(9424..10170)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg68_12"
                     /sec_met_domain="adh_short_C2 (E-value: 5.6e-76, bitscore:
                     245.1, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILISRSPSSCGG
                     AAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGITRDSLMLRMK
                     EEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQANYAASKAGL
                     IGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNSIPDNLKEEIVKKIPLKEQGSVEDIAA
                     LTAFLASDDARYITGQVIACDGGMTM"
     CDS             complement(10299..10817)
                     /locus_tag="ctg68_13"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPAAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESADNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LIEKMEKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLVEPDEDGTPPGA
                     LRENEEAGQ"
     CDS             complement(10881..12491)
                     /locus_tag="ctg68_14"
                     /transl_table=11
                     /translation="MLTIKNLTKSHAGRTLFRETEMTINWGERVALVGPNGAGKSTLFR
                     MILGEDTPDEGSISMDEYAIVGYLPQEASEPKDETVLEIALGITPEMEQAIHTIRTAEN
                     ANKTDTPEYAEAIDTFNAANGYQLEPKAKKILKGLAFRESDFHRPAREMSGGWIMRAYL
                     AKLLVLEPDLLMLDEPTNHLDLLSLLWLQRYLKNYPGAILMISHDRDFMDELVESVYDI
                     DNEELVEYRGNYSDFLQQKDVRFEQLQAAYRNQQKEIAHIQEFIDRFRSINSKAGQVQS
                     RIKQLEKMKIIQKPVARRKVFKFNFPQPPRSTQKVIELEKVCQSYGDRRVYENLDLLVE
                     RGERTVLVGPNGAGKSTLLKILAGIIPIDSGQRTPGTTTRIGYFSQARTENLNPENTVL
                     EEIMKCSAEIREEEARSILGSFLFRRLDVEKRVSVLSGGEKSRLSLVKFLVDPPNLLLM
                     DEPTTHLDLLSVEALVQALKHYEGTLVFISHDVHFIRSLAQKTLHVNRGTITAYAGGYD
                     YYLEKSGILDDEKGGITAE"
     CDS             12614..12952
                     /locus_tag="ctg68_15"
                     /transl_table=11
                     /translation="MPTTQTFRLLLAAALLCGWSSCCTPPAEDYIQQPYVQQQMSGLAN
                     AFLALLPPDQASLPAAGAEARWLADTAVVQSAAIARDNRTVLFGWLNNILVNSNLRDRG
                     LCWQVQQDL"
ORIGIN
        1 cttgacagga tgccatccct tccgggcatc agtctaattc ctgtaatcaa tgtttctctc
       61 tctcgaagaa agatggggcc gtcgctgtcg gacggggcct gcttaggttt cgtccggcat
      121 ttccaagtac ggtttcctgg attactgggt gccttccggt gtaacaattt tttacgctgc
      181 gcgacgatga ggaagcaact gtctggtatt ttattcctgg ttcaaggaaa cctggtaatg
      241 aaaaaactcc cgacagccga tgccgccggg agtttttaca gagcgtctta agaaggaatc
      301 ttctttagaa acagaggcct tccttggcgt tggcccgcat gaagtcgcgg ttgaggcggg
      361 cgatgttgtc cacgctgatg cctttcgggc aggcggcttc acattcatac tggttcgtgc
      421 agttgccaaa gccttccgct tccatctgct tcatcatggc caggacgcgc ttggaacgtt
      481 ccggctggcc ctgcggcagc agattgagat gggcgatctt ggcggaggtg aacagcatgg
      541 cggaggcgtt tttacaggag gccacgcagg cgccccagcc gatgcaggcg gccgcgtcaa
      601 aggcggcgtc cgccttcact ttttccacgg cgatgttgtt ggcgttcggc gcggaaccgg
      661 tacgcacgtc aatatagcct ccagcggcga tgatgcggtc cagggcggag cggtccacca
      721 tcaggtcccg caggattggg aaagccttcg cgcggaaggg ttcaatccag acggtatcgc
      781 cgtccttgaa cttgcgcatg tgaagctggc aagtggtcac ctggcgttcc ggcccgtggg
      841 gaatgccgtt gatggtcagg gagcacatgc cacagatgcc ttcccggcag tcgtggtcaa
      901 aatggatggg ttccttgcct tccttgacca ggccttcatt gacgatgtcc agcatttcca
      961 ggaaggaggc gtccaccgga atgtccttgg cggcataggt ctcaatgcgg cccttggctt
     1021 cccggttttc ctggcgccag accttgagag tgagattgag tgttttagcc atgttataat
     1081 ctttcttttg agtgttaatg tattggctat ctttacttgt agctgcggat ggcaaggtgc
     1141 acgttctcga aggtcagcgg ttccttgtgg agaacaggca ggctgtccac gccagtgtat
     1201 tcccaggcgg ctacataggc gtattcatcg tcgttgcgct tagcttcgcc gtccggcagc
     1261 tggtattcca cgcggaagtg ggcgccgcag gattcctggc ggttcagggc gtcatagcag
     1321 agcagctggg cgaattccag gaagtcggcc acgcggcagg ctttttccag ttccgcgttg
     1381 atgccgtccg ccgtgccggt tacgcgcacg ttttcccaga attccttgcg gagctgggga
     1441 atgcgttcaa tggcgtgggt caggctttct tccgtgcggg ccatgccgca gtcttcccac
     1501 ataatgaggc ccagttcccg gtggaaggag tccaccgtct tggtgccctt cacattcagg
     1561 agcttgttga tgcgttcctt cacttcgtct tccgcagcct tgaattccgg ggcggcggtg
     1621 gtgacggcgc cgggtttggt ggtcgtcagg taagcgggca gcgtggcggg aatgacgaag
     1681 tagccgtcag acaggccctg catcagggcg gaggctccca ggcggttggc gccgtggtcg
     1741 gagaagttgg cttcaccgag gacgtgcagc cccttcacat tggacatgag gttgtagtcc
     1801 acccacaggc cgcccatggt gtagtgggag gcggggtaga tcatcatggg cgtttcatgg
     1861 gggtcgtcgt ccgtgatttc ttcgtacatg tcaaacagat tgccgtattg gccgtcaatc
     1921 cattcgcgac ccatgcgctt gatttcatcc gcaaaatcca ggaagacgcc cttgccggtg
     1981 atggccacgc cgcggccgtc gtcgcaggct tccttggcgg cgcgggagga aatgtcgcgc
     2041 ggggccaggt tgccgaagga gggatacttg cgttccaggt agtagtcccg ttcttcttcg
     2101 ggaacatcgg aaggcttgat ttccttttta cggatttttt ctgcggtttc acgggacttg
     2161 ggcacccaga tgcggccgct gttgcggagg gattccgaca tcagcgtcag tttggactgg
     2221 tagtcgccct tgaccggaat gcaggtgggg tggatttgcg tgaagcaggg gttggcgaag
     2281 aaggcaccgc gcttgtaggc cttgtaggcg gcagtgacgt tgcagcccat cgcgttggtg
     2341 gacaggaaga acacgttgcc gtagccgccc gtgcagagca ggacggtatc ccctgcgtag
     2401 gatttgattt cgccggtaac cagattgcgg gtgacgatgc ccttggcttc gccgtccacc
     2461 agcaccagat ccatcatttc atggcgcgag aacatttcaa tgtgtccctt ggccacttcc
     2521 ttttccaggg cctggtaggc acccagcagg agctgctggc ccgtctgtcc gcgtgcgtag
     2581 aaggttcgct tgagctgggc gccaccgaag gagcggttgt ccagcaggcc gccgtattca
     2641 cggccgaagg gaacgccctg ggccacacac tggtcaatga tgttggagga gacttccgcc
     2701 agacggtaga cattggcttc acgggcgccg cctttaacgg tgtcgtaaaa caggcggtaa
     2761 acggagtcgc cgtcgttctg gtagttcttg gctgcgttaa tgccgccctg ggccgcaatg
     2821 gagtgggcgc ggcgggggct gtcctggtag cagaagcatt tgacgttgta gccaagttcg
     2881 gcaagcgtgg cagcagcgga ggcgccagcc aggccggaac ctaccacaag caccgtgtac
     2941 ttgcgcttgt tgttcggatt gatcagtttg gactcaagct tgtacttgga ccatttgtcc
     3001 tgaatagggc cggagggaat tttggcatcc ggcatccagt cgcttacggg aaaattaatc
     3061 atgactttga gaggagttga tggttatttg atgataccca gaagaaccga gaccggcacg
     3121 gagatgaagc ccaggcagat aatcgcgccg taggcgatgg cgataaagtt gtagaagggc
     3181 cggattttgc gggaatcgac gcccacagtc tggaagatgg actgtacccc gtggcgcaga
     3241 tggctgaaca gcatcagaac ggccaggatg tagaaggcgg agcaccatac gttggaaaat
     3301 ccggtcacga tcatcttgta cacgtcaaag gtttccaccg taccgtcgga aatgaaggtg
     3361 gtgaactggg cggggtcgta tcctacgcgc agggtgtact ggtacaggtg gtagatcagg
     3421 aacaccagga cggtcagacc ggtatagatc atgtagcggg aggagagcgt tgccttgatg
     3481 gtgttcttga acacgtaggg ttcgcgggcc gcatggtttt ccagcttcag ctggatggtc
     3541 agccagacgt ggatgatgaa gatcaccgca agccccgcgc ggattcccca gagggctgct
     3601 tccggcatgg agtgcaggcc gtgggcgtag gtgttgatcc attcagggcc tccgaagatg
     3661 agaaggttgc ctgccaggtg tcccgcaagg aacaagacca aacataaccc cgtcagagcc
     3721 acaatgattt tgcggccgat ggaggatgtc acgaatgtac atatggtttt tactagtgca
     3781 ttcataggcg ctctaatgaa ataaatgcgt cttcacagga tgcccggttc aagcccggat
     3841 ggcaagcctc ttcttgaatt tccggcgctt ttcggatttt tgaaaagccg gggaaagaga
     3901 ttgctgttta tcagtttgga atggttatca ttttgttgcc tgttccggct tgacgaggct
     3961 ttccgcatag gcgtatcgtc tgtgcatgaa aagaagtaaa aaggaagtgc tggacgcgga
     4021 tttcgcagcg gcgcgcgccg gcgttctgga tgtggccgca tttctggacc gggtggaccg
     4081 cggggaaggg gaggcggatt tccgttacca tgccctgatg gatgttcttc ccctcttatc
     4141 cgcatccggc cccggacgcg tccgggccat tctggaagcc ctttcctaca gggatgacac
     4201 cgtgccggaa accgccgcag ccaaagcggc ctgcggagcc ccgaacctca gcaaataaga
     4261 atgatggctt tcatagaacc tcatatacat atggtgtgcc gcaccacgga cgaataccgg
     4321 gccatggcgc aggccggctg cctggcggta ggggaaccgg cgttctgggc cggttacgac
     4381 cgttcgtccg cggacggttt ccgggattat ttcgtacagc ttacggaatg cgaacccgcc
     4441 agggcggcca agttcggcat ggaccattac acatggctgt gcatcaatcc caaggaggcg
     4501 caggacgtgg ctttcgcgcg ggatgtaatg aaactgattc cggagttcat cgaccggccc
     4561 aatgtcctcg gcattgggga aataggactg aaccggaata cttcccatga aatgactatt
     4621 tttgaggagc atctggatct ggcggtgcgc ctcaaccagc ttgtgctgat tcacactccc
     4681 catctggaag acaagcttaa ggggaccgta atgattcttt ccgccctgaa aaaccgtccg
     4741 gatctggacc cttgccgcgt gctggtggat cactgtgagg aacatacctt cccgctggtg
     4801 aaggaggccg gctactgggc cgggctgacc ctttatccca ccagcaagct gaatcccaag
     4861 cgggcggcgg atattctgga attgtacgga atggaccgtg tctgggccaa ttccgcggcg
     4921 gactgggggg attccgatcc cctggcgctg acggccttgg cctgcgagct gcgcaggcgc
     4981 ggtttttccc ggcaggaaac ggaacgtctt ctcctggaaa atccggagac attcatggga
     5041 cagtccccga agttccggaa agtgtcatcc cgctaattcc gcccgcggcg cggcggaggg
     5101 tacggccctc tagtccccgt ccgggaaaaa gacggtgagg acggcgccca ggatgaccgc
     5161 cgcgtcatcc agaaggccca gcctgccgat tccgtcaaac aggaattcgt cgggagtcag
     5221 gatgtaggcg ccggcggcgg ccagaaggca tatattccgt ttgttgaaaa aacgcggttc
     5281 tccttttctg cttttgaaat accggaacag gcgcagtagc agctgctgtt tttgaaggtt
     5341 catggacggg aacgggggat aaaggttcaa gctcagccat tttcccactc cttttccctg
     5401 tttcggggaa ggagtctgtt gccgacggac ggaaaccgca gcgatccgga ccgtgcgggg
     5461 aaatggattg ctgaaaggat gggctgttcc ggatgctgag ggaagccggg ctttgcatgc
     5521 tccggttccg gctgtcccgg catgggaaaa aggggcgtgt acggaagtgg ggcggggccg
     5581 gaagctcttg aaatgaccct cccgggggag cctgaatgcc atttccccgt caagtgctgg
     5641 ccgtgagggt accgcagcaa atggaagctt cttcccccct gttttttccg gcagatgttt
     5701 gaacggataa ggaaaaggcc ggctcacgat tttgtgagcc ggcctttgaa tatagggagg
     5761 cggacggtac aggcttatgc cctgcggcgg cgcatcatca gcgcggccag tcccagcagg
     5821 cccagggaag ccgtggcggg ttccgggatg ctggcgattt cactcatcag ttgaccaact
     5881 tgttcctggg aaaggaggga gtcgtgaatg tagagctgtt cgatggattc agccagtcct
     5941 gcgtccatga gaatctgatc aatttgctgg ttgccgaatt tcaggccgct gttggaatag
     6001 tacgtagcgc tgtctccaaa atagatgcgg gtgccaagat ctccggtgac tacggaaatg
     6061 gtcagggaac cttccgtgcc cagcggggtg tcaacgacgg gcccgttgta tgaggtgttg
     6121 ttccataatc cctggagttt ccggtccgtg ttcaggccca cgccccagct tacactgctg
     6181 tttttggcgt taaacagagc ggtataggtc tccggagtgt tgattttgga caggtcaaga
     6241 accatcgtca cagacataac gtcgcggttg ttggcaccgt atccgttgaa ggttatcccg
     6301 gacaacgtca gattgctgtc gtcagacgtg atggaaacgg aatctttccg ggtgccgaaa
     6361 tccgccgttt gggaggcaaa gtccgaatat cccacgatgg agctatccaa cagagcggta
     6421 gccgcggtag cgcttaggct catgccggcc gaaagaatca gggtggataa taatttattc
     6481 atggtcagta tcttaataaa atgattcaag gttcaatgta tgtacttgtg cttgaataac
     6541 gaatttggaa tccgcaagca attaaaaata ttaagagtta gtatattgta tttataattc
     6601 attgaaaata atgatttttt aatatctctg gtccttttgc taagatgacg ggtcagtctt
     6661 tgttattcat tggtttcatg attgatttgg cctctttttc attacttgac ggattccaaa
     6721 ttcgattggg gaattccaaa ttcgctacaa gttgccatcc aaaaggaata ataaatatga
     6781 agaaaacact gacattttta atcgcgatgg gaagctttgc tgtttcctcg gaggcagcga
     6841 ccgtttttaa ttattacact cccggtacgg ataattacaa tagtaccatc catgggtttt
     6901 atcttggcct ggggtcttct tccctggctc cttccgattc ctcttctccc tcctccctgt
     6961 ccggagagat cagactggac agttttacgc tgcgcggagc cgccaacaat ttgggcgcta
     7021 atgtcactta cggcttcctg gtgctgaatg gctccgacaa ttcggtcatc ggctggagca
     7081 ccaatacggg aactactgca gcagggatta atctgacgtt cagtttttct tccctggatg
     7141 gttctcccct gcttcttgac gcggcattga cataccgttt cctggccgtg agccagtccg
     7201 tgatggactt gatgcaggat acgtctaaaa cgtatttata tgctgcgggg ggaacagccg
     7261 cccctactgc taacacggaa ggagataccg taacgatcag cggcggattg actgctcccg
     7321 gcatccgcgg ccattatgac gccgagggag cgcctggtga ttctgtcgtt attacgggag
     7381 ccaacggaac caatactttc agcttattat ccccgatttt cacggaaatc cgaggggaaa
     7441 tggtgccgga accagccacg gtttccctgg gcctgctggg actggccgcg ctgatgatgc
     7501 gccgacgcag ggcttgagct tcctgatggc gaaaaatcgg cggatgagag ctgttcttgc
     7561 ggaacagctc ttgtttttta tatccagaga ggaagaattg cttatccgta tgcgggattc
     7621 atgccctccg gaaggtacgg aatttccggg ggcagggggc cgtatccggt tttttcggca
     7681 tggcggcaat ttgctggaaa cgtttttgag acgcagtacc ggaaagcttt ttctttaccg
     7741 gaaaatgccg tcaaattcgg cagcgcgctt ttcgtccata tggtacacgg cagctttcac
     7801 atagtggcct ttcaggccgg atagggaacc cctttgcagc tcacagacct ggagggccgc
     7861 cgcatacata ttattcgccg tcctattccc cggcgctggt atttcggaag aacggcaatg
     7921 ggccccatgc ccagcacttc atattctttt ccatcgtctg ccctgatgac ggacgttgca
     7981 tcaacgatgt ttcccgacga tgcggctgcc gtggacggcg actgcatcca gctccgggat
     8041 gaaggacgga ctgacgcgca tgatatggag caggtaatgt tcatggcagc cggggacgaa
     8101 atagttccag aacgcttctc tcgtgacatg ttccgtttcg gcatggtctg aggattgttc
     8161 cgttcttaat gcaatggtca tgaaaggttg ttctttacgg ctcccccttg gagaaattcc
     8221 agaggcggtg catcgtcata atgtccggaa tgttcatggg gcgcaccacg cggaacccga
     8281 tcatgcctcc gtccgtcagg taccagatgc ttttagggtt ttgaggatcc tgacggctcc
     8341 aggcgggggt gctggcgcgg cgcgcagcgc ttctcaggct gtccgggtcg tcttcccacg
     8401 aaccgccgcg aacgatgtga ggggcgccgg ggatgatgac caaggggtct ttcgcgggca
     8461 agccgctccg tttgccgtag gcatccggaa cgtaagagtc caaaacccat tccgccacat
     8521 ttccgtgcat gtcccggagt ccccacttat ttggtttttt agagcctgtt ttctggtagc
     8581 ggtcattgga gttgttccag taccaggcgt actggtccag agaggcttcc ccgtttccgt
     8641 aagaataggc gccgggggag ccggcccggc aggcgtattc ccattccgcc tccgtgggca
     8701 ggcggtagta atgcccggtc tgggcgctca gccattcgca gaatttgctg gcggcgtggt
     8761 gggacatgga gatggcgggc agaccgtgtt catagccgtg gcccatgccc aggttcatgg
     8821 cggtgtaggg ggcggtaggc tgcgtaacgg agtcccacag ttcgtcatcc ggctgttcct
     8881 ccagaagctg gccgtccttg gcgcgcggac gcccgttttc catgaaggcc gtataaagtt
     8941 cccaggggat ttccgtttcc gagatccaga agggggagat gctcacttta tgctgcggac
     9001 cttcgtccgg tttccggtgc ggctcttccg cgggactccc catgaggaac gttcctcccg
     9061 gtatggcgac catgcgcagg gaagctcccg ccacgggaac cgtttccgtg taggattcaa
     9121 aacgtgccgg atttccggaa gcttcaatga gctgatggat ttggcgcgtt gtgccgacca
     9181 gctcccggga cggcaggtca tccggaatgg gaagggcagg accggcagcg cggtccagtt
     9241 cccgtttttg cagcgcggat cggctttctc cccactggcg tgcgctggta atgcgcgcgg
     9301 catcttccgt ggccgggcgg ggggaattat tttcttcccg gcacccggcc agcagggcgc
     9361 ttcctcccag aaagcaggaa acaaggaaaa tgccgcgcat ggaatggaga aaaccggaat
     9421 gccctacatc gtcatgcctc cgtcgcaggc aatgacctgc ccggtgatgt aacgggcatc
     9481 gtcagaggca aggaaggccg tcagggcggc gatatcttcc acggaacctt gttctttcaa
     9541 aggtattttc ttaacgattt cttccttgag attgtcggga atggaattgg acatttccgt
     9601 ggagatgaag ccgggagcaa tggcgttgca cgtgactttg cgcggagcga attcctgagc
     9661 cagtgatttg gtgaaaccga tgagacccgc cttggaagcg gcgtaattgg cctggccgat
     9721 gttgccgacg agaccgatga cggagctcat gttgatgatg cgcccggccg gggatttcat
     9781 gagaacgcgc tggagggcct tgaccgtatt gaacgcgctt ttcaggttgg tgtccagaac
     9841 agcatcccag tcttcctctt tcatgcggag catcagggag tcccgcgtga tgccggcgtt
     9901 gttcaccagg atgtcaatct gcgggaagtc tttcaaaatg gcggccatgg tttcctgaac
     9961 ggccgcgtaa tccgctacgt cgcaggggta ggccttgcag gaatccggaa attccttgtt
    10021 gatttcttct gcggcccccc cgcagctgga tggactgcgg ctgatcagga tgaccctggc
    10081 tccttccgaa gcgaagcggc gcgcgacggc attgccgatt ccgcggcccg cgccggtaac
    10141 gatggctgtt ttacctgcta acttttgcat gctgcccaca gtaaacccgt ttttcacggt
    10201 tccggcaagc ttgaaatgga cttggccgcg caggaaccca tacggggaag gggcgtgccg
    10261 ggaatgaaaa aagagggggg gagaaacggg gcggggggct actgtccggc ctcttcattt
    10321 tcccggagtg caccgggggg cgtcccgtct tcatccggtt ctaccaggtc gctgaattca
    10381 tccgaatttt ccaaaatgtc ctttaaggcg gcggaaccgt aatagcgggc ctcaaacagg
    10441 cgtttgcctt cctgcctgca gcggttgtcc agcatttcca ttcgtttttc cattttttct
    10501 atcaaggcgt cttctttctc cttttccgca tcgttcaatt tatcctgaag ctggaggaaa
    10561 tgccggatgt ccttctgaat gtcctgcagc gttttgacgg cgttgtccgc gctttccttg
    10621 tcctgaacgc ctgccaacgt ctgctggata ttgatggcaa aggaaaaggc ctggttgatc
    10681 agggattccg cggaaggaat tttttccgcc ggagccgctg ctgcggggga agccgttccg
    10741 gcggccgttt caccaaatgc aagagaggct ccggacagaa gcgcagaata taagagagga
    10801 acaagaaaag ccttcatcct gttcttttaa ggcaggatga aatccacggc aaggaaaaag
    10861 gggaaactga aaaaagagcc ttattccgcc gtgatgccgc ctttttcatc gtccagaatg
    10921 cctgactttt ccagatagta gtcatatcca cctgcgtagg cggtgatggt cccccggttc
    10981 acatgcaggg ttttttgtgc cagggaacgg atgaagtgca catcgtggga gatgaagacc
    11041 agtgttcctt cataatgctt cagagcctgc accagggctt ctacggacaa aaggtccagg
    11101 tgggtggtcg gctcgtccat cagcaggagg ttgggcggat ccaccaggaa tttgaccagg
    11161 ctgagccgcg atttttcccc gccggaaaga acgctgacgc gtttttccac atccagcctc
    11221 cggaacagga aggaacccag gatggaacgc gcttcttcct cccggatttc agcgctgcat
    11281 ttcatgattt cctccagcac ggtattttcc ggattcaggt tttccgttcg cgcctgggag
    11341 aagtagccga tgcgcgtcgt ggtaccggga gtgcgttgtc cggagtcaat ggggatgatg
    11401 cccgccagga ttttgagaag agtggatttg cccgcgccgt tcgggcctac aagaacagtg
    11461 cgctccccgc gttccaccag caggtccagg ttttcataaa ccctgcggtc gccataggat
    11521 tggcagactt tttccagctc aatgactttc tgggtgctgc gcggaggctg ggggaagttg
    11581 aatttaaata ctttcctgcg ggctaccggt ttttgaatga ttttcatctt ttccagctgc
    11641 ttgatgcggc tctggacttg cccggctttg gaattgatgg agcggaaacg gtcaataaat
    11701 tcctgaatgt gcgctatttc cttctgctgg ttgcggtagg ccgcctgaag ctgctcgaag
    11761 cgcacgtcct tttgttggag gaagtccgag taattgccgc ggtattccac cagttcttcg
    11821 ttgtcgatgt cgtacacgct ttccaccagc tcatccatga aatcccggtc gtgggaaatc
    11881 atcaggatgg ctccggggta gtttttcagg tatcgctgga gccacagcag ggacaggagg
    11941 tccaggtggt tggtaggttc gtccagcatc aggaggtccg gctccaggac aaggagcttg
    12001 gccaggtacg cgcgcatgat ccagccgccg gacatttccc gggcggggcg atggaagtcg
    12061 ctttcccgaa aggccagccc tttgagaatt ttcttggctt tgggctccag ctggtaaccg
    12121 ttggcggcgt tgaaagtgtc aatggcttcc gcgtattccg gcgtatccgt tttgttggcg
    12181 ttttccgccg tccggatggt gtggatggcc tgttccattt ccggcgtgat gcccagggcg
    12241 atttccagaa cggtttcatc cttcggttcg ctggcttcct ggggaagata gcccacgatg
    12301 gcgtattcat ccatgctgat ggagccttcg tccggcgtgt cttctcccag aatcatgcgg
    12361 aacagggtgg atttgcctgc tccgttgggg ccaaccagag ccacccgttc cccccagtta
    12421 atggtcattt ccgtttccct gaacaaggtc cgtccggcgt gggattttgt gagatttttg
    12481 atcgtcagca tggtgaagag aggatgtatt ctaccgggat ggaaagggga aggcaagagc
    12541 cgtcagggcg gaggcaggca tttttgaaag ctttactgga tttttacgcg tagtctgcta
    12601 gccttggcgc gccatgccga ccacgcagac attcaggctt ttgcttgctg ccgccctttt
    12661 gtgcggatgg agttcctgct gtactcctcc ggcggaggat tatatacaac aaccttacgt
    12721 gcagcagcaa atgtccgggc tggctaatgc cttcctggcg ctgctgccgc cggatcaggc
    12781 ctctcttccc gctgccggag cggaggccag gtggctggcg gacacggccg tggtccagtc
    12841 cgcagcgatt gcccgggaca acaggactgt gctgtttggc tggctgaaca atattctggt
    12901 caattccaac ctgcgcgaca gggggctgtg ctggcaggtc cagcaggatt tgt
//
