LOCUS       c00072_gnlPro..        13701 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JFANECFC_72.
ACCESSION   c00072_gnlPro..
VERSION     c00072_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 15:19:45
            Original ID  :: gnl|Prokka|JFANECFC_72
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13701
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13701
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2568:12570]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2569..12570
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..13701
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13701
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             26..1690
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OAD_beta"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg72_1"
                     /sec_met_domain="OAD_beta (E-value: 1.5e-159, bitscore:
                     520.3, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLFDSLITFLQGMGVFSLSWQMVGMWGIAILLLYLGVAKQYEPL
                     LMVPIAFGALIANIPDNGMLITQLNQQVISSNEQGEVTATSLNNVGYLRVHVAPLQQAP
                     SKVPANLTTPESRSQYQEIMQQPMQVYPGSQLTVSKIKSVRESQEKAKADAARLGDDSL
                     TVDPNLKDFQNVTEDNGNEPVFLLTNGEGTTVVRQQGVNYFDTSGNRIPVDLKTQKLEP
                     LVVSAAGKYVAVGQHTQELLVTSIHGGLYDWIGLGIKAEIFPPIIFLGVGALTDFGPLL
                     AAPRTLLLGAAAQVGVAATFFMALFMGFTPNESASIGIIGGADGPTSIFLTMKLAPHLL
                     GAVAVAAYTYMSLVPLIQPPIMALLTTKKERLIRMKSLRTVSKSEKLFFAVLVTIVTIL
                     LIPDASPLIGMLMLGNFLRECKVTERLVQASQNEIINIVTIFLGTSVGLTMQGDRFLQS
                     ETLLIILLGIVAFGVATAGGVIAAKIMNLIWRKNPVNPLIGSAGVSAVPMAARVSHNVG
                     QKYDPSNYLLMHAMGPNVAGVIGTAVIAGYYIATLAK"
     CDS             1728..2507
                     /locus_tag="ctg72_2"
                     /transl_table=11
                     /translation="MNSAASFSTPPEEEGPCGDWTYHEWAEAFSTNDLARALPPGHIAV
                     CRVQTGGRGRFNRKWIGEEGGLWASFTVPLSAPEDTAAGVHWGHLPLVAGLALFNMLRG
                     MGLDSVRLRWPNDLLAGKSKLAGILVERPAENMAVIGIGINVFNDVSSIAGEIKDPPAR
                     LADLVRDCPSLHAVMASLGSHLNQVLSVFSHGGVPALQEGLSRAWAGERPVSILTDDET
                     VRGIFTGIDDQGNPVLSLPAGTVRTIPAHLINRLLEE"
     CDS             2569..4065
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: AcetylCoA_hyd_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: AcetylCoA_hydro"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg72_3"
                     /sec_met_domain="AcetylCoA_hyd_C (E-value: 7.3e-47,
                     bitscore: 148.9, seeds: 181, tool: rule-based-clusters)"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 5.2e-44,
                     bitscore: 140.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYKVLTPEEAASLIKHGHHIGLSGFTPAGTAKAVTAALAKIAEA
                     EHEKGNPFQVSVFTGASTGDSCDGILSRAKAIRYRAPYTTNVDFRKAVNNGEIAYNDIH
                     LSQMAQEVRYGFMGNVDIAIIEACEVTADGKIYLTAAGGIAPTICRLADKIIVELNAAH
                     SKSAMGLHDVYEPLDPPYRREISIFKPSDRIGKPYIQVDPKKIVGVVETNWPDEARSFA
                     AADPLTDKIGQNVADFLAADMKRGIIPSTFLPLQSGVGNIANAVLGALGRDKTIPAFEM
                     YTEVIQNSVIGLIREGRVKFGSACSLTVTNDCLEGIYRDMDFFRDKLVLRPSEISNSPE
                     VIRRLGVISINTAIEADIYGNVNSTHIGGTKMMNGIGGSGDFTRNAYISIFTCPSVAKD
                     GKISAIVPMVSHHDHTEHDVNIIITEQGVADLRGKSPKERAQTIIENCVHPDYKNILWD
                     YLKLSDGKAQTPQSIRAALGMHAELARSGDMKNVDWAQYK"
     CDS             4185..4886
                     /locus_tag="ctg72_4"
                     /transl_table=11
                     /translation="MNWMIYPAARAFIKVCSVLFGTGAAAAVLIHLFMPFFLRSPRTAA
                     PFLLLGTGAELLSILSLSFLMFWGVRVLLASRGSRITRNLSMLAFLPALYALLIPFAGM
                     PVPSQYTEMDRVWEAVLLLSAVTSFFSFPYTAGYGAAGRRLFLAWGIAAAGCGLQSALF
                     FLAVLLRQFLSTAVPSLAAPVAWLAVLLSCGLEIMLAALSAILAQRLFKEVMSIASMPE
                     PIDPSMPGNRP"
     CDS             complement(5090..5953)
                     /locus_tag="ctg72_5"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLHPVTLSVSKQLLPVYDKPMVYYPISVLMLAG
                     IREILVISTPRDLPLYRDLLGDGSRFGVSFKYREQPRPEGLAQAFIIGEEFIGKDSVAL
                     VLGDNIFYGRGLTEKLRRAAELTSGATIFGYQVHDPQRFGVVEFNEEGKAVSIEEKPPR
                     PKSDIAVTGLYFYDNRVVEIAKRIPKSSRGELEITSVNQEYLKQGLLRVEKLARGYTWL
                     DTGTHDTLLEASMFVRTLEHHQGFKVACLEEIAFNNGWISQETLRSQAGAMNNNGYGRY
                     LDELVK"
     CDS             complement(5963..7015)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GDP_Man_Dehyd"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg72_6"
                     /sec_met_domain="GDP_Man_Dehyd (E-value: 2.3e-99, bitscore:
                     322.6, seeds: 258, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVIVTGGAGFIGSNLVRLLLERGHEVLNIDALTYAGNIHSLDGS
                     ADSPAYRFLHADVRDASLMRRTLREYAPDWVMHLAAESHVDRSIDDPGNFMTTNVMGTF
                     SMLQAALEYYRSLEGEKKERFRFHHISTDEVYGSLGKEGLFTESTPYRPHSPYSASKAS
                     SDHLVRAWHDTYGLPVLITNCSNNYGPYQFPEKLIPVVILKALGGEPIPVYGKGENVRD
                     WLYVGDHCEALLTVVSCGKPGETYNIGGNNEKTNLELVELLCSHLDELRPRPDGRSYRE
                     QISFVQDRPGHDLRYAIDASKIRRELGWTPRQDHSSGFRKTIQWYLDHEEWWRGILSGE
                     YRLERLGTNG"
     CDS             complement(7147..8091)
                     /locus_tag="ctg72_7"
                     /transl_table=11
                     /translation="MTSGGDAAGMNPAIKAAVDHARQLGMNPYVVYDGLEGLIDGKIKE
                     ATRELTNDMIYRGGTLLRSSRSKRFFDYEFRKQAYEHLKERNIDKLIIMGGDGSFRALN
                     DFFNDFEVPFAGIPATIDNDIAGTDYCLGVDTAQNVILDCIDSVRDTARSHHRAFVIET
                     MGRDCGYLAMTTALCSAADICIVPEIPYDLESIYKRLQPVINEEGSCIIAVVAEGTRVA
                     QYLTRWLTERAGMDTRLTVLGHVQRGGSPTARDRLMGTRFATRAVEALNNGDINQIMVY
                     HDGQYGYASLDSVAGQQYSVNQDIINLCRELSC"
     CDS             8220..8951
                     /locus_tag="ctg72_8"
                     /transl_table=11
                     /translation="MNDTAAAILKATAALRDGTEKLRFESPVHVTYNPLTYAWGPHEQY
                     VRTYGNGEKSHLFLGMNPGPFGMAQTGVPFGEVDAVVNWLHIRGEVGRPEHTHPKRPVE
                     GFGCPRSEVSGRRLWGLFAEAFGTAENFFRHNYVANYCPLIWMGATGANITPDKLPAEQ
                     RAAVDAVCMEHLLSLITILNPHTLVGVGAYATQKLRDAASRLPGKSFTIGTLLHPSPAS
                     PIANKLWPEHPIQQLKELGIL"
     CDS             9320..10285
                     /locus_tag="ctg72_9"
                     /transl_table=11
                     /translation="MAISDYIVTIGLEVHCQIKTKSKMFCSCETGFGFEPNTRVCPTCL
                     GLPGALPVLNEFAIERTLLTGLMLGCSSPEISQWDRKNYFYPDMAKNYQTSQLDLPLCL
                     GGEVPLYPWSYPNDVIKAGIPPFRTVKLTRIHLEEDAAKITHHANYSLIDYNRAGSALM
                     EIVSEPDIDTPEEAYAYLKSLQQILNYGDISDADMEKGQMRCDVNISLRPHGQKELGAK
                     VEMKNINSMSAVRRALHYEIQRQAEELDMGIPQSSPPAAGTTNAEKASSCEPRKTRTIT
                     VISPVRIWFPYARPRWWRKCAGRFPNCLRNGRNASWKNTA"
     CDS             10267..10785
                     /locus_tag="ctg72_10"
                     /transl_table=11
                     /translation="MEEYGLSEYDANVLVGDLELARFFEEAARGTASGKKIANWVINNI
                     SAVLNEKGMRPSECPVKPGAIRELIAIIDDGTVSNNQAKDVFAKMWDEPALAAAQAAKL
                     LGFEKADSSFLDGIVREVISANPDKVAEIQGGNEKLLNWLTGQVMKAAKGKANPKIVTE
                     ALKKALSME"
     CDS             complement(10840..12570)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg72_11"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.3e-34, bitscore:
                     108.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYRVADQIVEILEKAGVKRIYGIVGDSLNPVTDALRRRKTIEWIH
                     VRHEEVAAFAASAEAQLSGNLAVCCGSSGPGNLHLINGLFDAHRNHAPVLAIAFHIPQS
                     QVGMEYFQATHPEQLFKECSAYAELVSEASQAPSILMSAIQHAWARRDVGVVVLPGDIA
                     DAPAEMKNLVHPPSYTRENVVPEHESVSLLARMLDDHRRITFFCGAGCAGAEDKVVRLA
                     HRLKAPIAYTWRGKDHFEHDNPLGIGMTGLLGWGDAYKAMHESDMLVLWGTDFPYFNFI
                     PTKPEIVQIDRRGEVLGRRCRLDLGICGDVSVTAEALLNMVQEKTDSGHLDAALKRHAR
                     DVKEMNAYMEGNDKESPIRPEQLTTALNRHAASDAVFTVDTGTPCIWSARFLCATPGRR
                     TLASFNHGSMANAMPMAIGAQMEYPERQVIALCGDGGLSMLLGDLITIVQYRLPVKIVV
                     YNNDCLDFIQLEMQAAGLIPWQINLNNPSFAAVADAVGIKGFLLDKSSQVDQMVDMFLN
                     YPGAALLDAHVDRDALALPPYISMGQAADFSLAMMKQTLAGEVKQVWNTLAGNRKLFKP
                     "
     CDS             complement(12735..13463)
                     /locus_tag="ctg72_12"
                     /transl_table=11
                     /translation="MAIAACCSVPALASPGSLEPSAGTSYVAGTATTTEGIALGKDMTF
                     GSLSQSALPGSSIPYGGNFYASNYTISLWLDTSSLTEGTQTTLFGYYGTNVGQSYGTNA
                     LYLTSDAKLGMGDGNLNTSTGSFSQNRGDVSEASVVLGGGLLNVTLAVTGADQSQSVDV
                     YVNGSLLDTLSYNGNMNGNRSDIQSWINPNLTWGEIQWTDTKLSAEQIAGFAGLQVPEP
                     ASASLGILGLAVLMMRRRRS"
     CDS             13640..13699
                     /locus_tag="ctg72_13"
                     /transl_table=11
                     /translation="MNIKNKTQNRFFVEVLKLLY"
ORIGIN
        1 ataaaccgct acaaaaatat tccctatgag tctttttgat tcattaatca cctttttaca
       61 ggggatgggc gtcttctccc tatcatggca gatggtaggg atgtggggca ttgccattct
      121 cctcctgtat ctgggtgtag ccaagcaata cgaaccgctc ctgatggttc ccattgcttt
      181 cggcgccctc attgccaaca ttccggataa cggaatgctc atcacccagc tgaaccagca
      241 ggtcatctcc tccaatgaac agggggaagt aaccgccacg tctctgaaca acgtggggta
      301 cctgcgcgtt cacgtggctc cgcttcagca ggctccctcc aaggtgccgg ccaacctgac
      361 cacgcctgaa tcccgttccc agtatcagga aatcatgcag cagcccatgc aggtttaccc
      421 cggcagccag ctgactgttt ccaagatcaa gtccgtgcgg gaatcccagg aaaaagcaaa
      481 agctgacgcg gcccgtctgg gcgacgacag cctgacggtg gaccccaacc tgaaggattt
      541 ccagaacgtg acggaagaca acggcaatga accggtcttt ctgctcacga acggagaagg
      601 gaccaccgtc gtccgccagc agggcgtcaa ttactttgac accagcggca accggattcc
      661 ggtggatctg aaaacccaga agctggagcc cctggtggtt tcagccgcag gcaaatacgt
      721 ggccgtaggc cagcataccc aggaactgct ggtcacctcc atccacgggg gcctgtatga
      781 ctggatcggg ctgggcatca aggctgaaat tttcccgccc atcatctttc tgggagtagg
      841 agccctgacg gacttcggcc cgctgcttgc cgctccgcgc accctgcttc tgggcgcagc
      901 ggcccaggtg ggcgtagccg ccacgttctt catggccctg ttcatggggt tcaccccgaa
      961 tgaatccgcg tccatcggca tcattggcgg cgctgacggc cccacctcca tcttcctgac
     1021 gatgaagctg gctccgcacc tgctgggcgc cgtggccgtg gccgcataca cgtacatgtc
     1081 cctggttccg ctgatacagc cgcccatcat ggcgttgctg acgaccaaga aggaacgcct
     1141 catccgcatg aaatccctgc gaacggtcag caagagcgaa aaactgttct tcgccgtgct
     1201 ggtaaccatt gtcaccattt tgctgattcc ggacgcatcc ccgctgatcg gcatgctgat
     1261 gcttggcaac ttcctgcgcg aatgcaaggt gacggaacgc ctggttcagg cctcccagaa
     1321 tgaaatcatc aacatcgtca ccatcttcct gggaacctcc gtggggctca cgatgcaggg
     1381 cgaccgcttc ctgcagtcgg aaacgctgct gatcattctt ctgggtatcg tcgccttcgg
     1441 cgtggcaaca gcgggcggag tgattgccgc caagattatg aacctcatct ggcgcaagaa
     1501 tccggtcaac cccctgatcg ggtccgcagg cgtctccgcc gtcccgatgg cagcccgcgt
     1561 ctcccacaat gtgggccaga agtacgaccc ctccaactac ctgctcatgc acgccatggg
     1621 tccgaacgtt gcaggcgtga tcggcaccgc agtcatcgcg ggttactaca tcgccactct
     1681 ggcgaaataa ccagaattga aaattactcc cggcctcggc ccgtcccatg aattccgcag
     1741 cctcattttc cacccctccg gaggaggaag gaccatgcgg cgactggact tatcatgaat
     1801 gggccgaggc tttttccacc aatgatctgg cccgagccct ccccccgggg catattgccg
     1861 tctgccgcgt tcagacagga ggccgcggca ggttcaaccg caaatggata ggggaggaag
     1921 gcggcctgtg ggcatccttc accgtccccc tgtccgctcc tgaggataca gcggccggcg
     1981 tgcactgggg ccatttgccc ctggttgcgg ggctggccct gttcaacatg ctccgcggca
     2041 tggggctgga ttccgtgcgc ctgcgctggc cgaacgacct gctggcgggc aaatccaaac
     2101 tggcgggaat actggtggaa cgcccggcgg agaacatggc cgtcatcggc atcggcatca
     2161 atgttttcaa tgatgtatcc tccatcgccg gggaaatcaa ggaccctccg gcaaggctgg
     2221 cggatcttgt tcgggactgc ccttccctgc acgccgtcat ggcttccctg ggcagtcatt
     2281 tgaaccaggt tctttccgtc ttttcccacg gcggcgtccc cgcccttcag gaggggctgt
     2341 cccgggcatg ggccggagaa aggccggttt ccattcttac ggatgacgaa accgtccggg
     2401 gcatttttac agggattgac gatcagggca atcctgtgct atcccttccg gccggcaccg
     2461 tccgcaccat tccggcgcac ctgatcaaca ggctcctcga agaatgagcc tgccgctccg
     2521 tttttacacg gggtttcttt cttttttcat ccaacaaaaa tcactgacat gagttacaag
     2581 gtactgacac cagaagaagc agcaagcctg atcaagcatg gccaccatat tgggctgagc
     2641 ggattcacgc ccgccggaac ggccaaggcc gttacggctg cgctggcaaa aatcgcagaa
     2701 gcggaacatg agaaggggaa ccctttccag gtgagcgtct tcaccggtgc ttccactggc
     2761 gattcctgcg acgggatcct ttcccgggcc aaggcaatcc gctaccgcgc tccctacacc
     2821 accaacgttg atttccgcaa ggcggtgaac aacggggaaa tcgcctataa tgacatccat
     2881 ttatcccaga tggcccagga agtgcgctac gggttcatgg gcaacgtgga catcgccatt
     2941 attgaagcct gtgaagtcac ggccgacggc aaaatttacc tgacggccgc gggcgggatc
     3001 gctcccacca tctgccgcct ggcagacaaa attatcgtgg aattaaacgc cgcccacagc
     3061 aagagcgcca tgggcctgca cgacgtttac gaacccctgg atcctcccta ccgccgcgaa
     3121 atctccatct tcaaacccag cgaccgcatc ggcaagccgt acatccaggt tgacccgaaa
     3181 aagattgtgg gcgttgtgga aaccaactgg ccggatgaag cccgttcctt cgccgcagcg
     3241 gatcccctga ccgataaaat cgggcagaac gtggccgatt tcctggctgc cgacatgaaa
     3301 cggggcatca ttccctccac gttcctgcct ctccagtccg gcgtaggaaa catcgcaaac
     3361 gcggtgctgg gcgccctggg ccgcgacaag acgattcccg cgttcgagat gtacacggaa
     3421 gtcatccaga attccgtcat cggcctgatt cgggagggcc gcgtgaaatt cggcagcgcc
     3481 tgctccctga ccgtgacgaa cgactgcctg gaaggcattt acagggatat ggactttttc
     3541 cgcgacaaac tggtgctccg tccctcggaa atatccaaca gcccggaagt tatccgccgt
     3601 ctcggcgtca tctccatcaa caccgccatt gaagccgaca tttacgggaa cgtcaactcc
     3661 acgcacattg gcggcacgaa gatgatgaac ggcatcggcg ggtccggcga cttcacgcgc
     3721 aacgcctaca tctccatttt cacctgcccg tccgttgcca aggacggcaa gatcagcgcc
     3781 atcgtcccca tggtttccca ccatgaccat acggaacatg acgtcaatat cattattacc
     3841 gagcaggggg tcgcggacct gcgcggcaag agcccgaaag aacgggccca gaccattatt
     3901 gaaaactgcg tccacccgga ttacaaaaac atcctctggg attacctgaa gctgtccgac
     3961 ggcaaagccc agacaccgca atccatcagg gccgctttgg gcatgcacgc cgaactggcc
     4021 agaagcggag acatgaagaa tgtcgactgg gcccagtata agtaattccg catgccgtca
     4081 ttcgcattgg catccatgaa ttcacgttaa cccctcagga ccgcttccgc aaagggagcg
     4141 gtccttttcc tttttcccat cccctctact ctcttctctt cgccatgaac tggatgattt
     4201 acccggcagc cagggctttc atcaaagtct gctccgttct tttcggcacg ggcgcagcag
     4261 cggcagtcct catccatctg ttcatgcctt ttttcctccg ctctccccgg acagccgcgc
     4321 ccttcctgct tttgggaaca ggggcggaac tgctctccat cctttccctg tccttcctca
     4381 tgttctgggg cgtcagagtt ctgctggcct cccgcggaag cagaataaca agaaatctga
     4441 gcatgctggc cttcctgccc gccctgtacg ccctcctcat tccgtttgcg ggcatgcccg
     4501 tcccatcgca atatacggaa atggacaggg tttgggaggc cgtcctcctt ctgtcggccg
     4561 tcacttcttt cttttccttc ccttatacgg cgggatacgg tgccgcaggc aggagattat
     4621 tcctggcctg gggcatcgca gcggcaggct gcggtttgca gagcgccctg ttttttcttg
     4681 ccgtcctgtt gcgtcagttc ctgtccaccg cagttccctc cctggcagcg cctgttgcat
     4741 ggctggccgt tcttctgtcc tgcggcctgg aaatcatgct ggcggccctt tccgctattc
     4801 tggcgcagcg cctgtttaaa gaggtcatgt ccatagcatc catgccggaa ccgattgatc
     4861 cttccatgcc gggcaaccgt ccctgacttt cctcccctcc gtttttaccg gcctgccgga
     4921 agagcaccct cattccccgg catgaaaggc ttttacggct ttgcgcaaaa agccgtccgg
     4981 aaatttccgc cggtggaacg gaatccgtat ggaaagcaac ccgccccacc ccggaaagcc
     5041 gcgggttcgc aggccccccc tcccgtttcc acgccgacgg cagacagccc tatttcacca
     5101 attcatccag ataacggcca taaccgttat tattcatggc tccggcctgg gagcgcagcg
     5161 tttcctggga aatccagccg ttattaaagg ctatctcctc caggcaggct accttgaacc
     5221 cctggtgatg ctccagagta cgaacgaaca tggaagcctc cagaagggta tcgtgcgtgc
     5281 ccgtatccag ccacgtatag ccgcgcgcca gtttttccac gcgcaacagg ccctgcttca
     5341 ggtattcctg attcacagag gtgatttcca actcgccgcg ggaagacttg ggaatccgtt
     5401 tggctatctc caccacccgg ttgtcgtaaa aatagaggcc cgtcaccgca atatccgatt
     5461 tgggcctggg cggtttttcc tcaatggaaa ccgccttccc ctcctcattg aattccacta
     5521 ccccgaaacg ctgcgggtca tgcacctggt aaccgaaaat ggtcgctccg ctcgtcagtt
     5581 cggcggccct cctcagcttc tccgtcaggc cgcgcccgta aaaaatattg tcccccagca
     5641 ccagggcaac ggaatccttt cctatgaact cctctccaat aataaaagcc tgagccagcc
     5701 cctccggcct gggttgttcc ctgtatttaa aggaaacgcc gaacctgctg ccgtccccca
     5761 gcaaatcccg gtacaggggc agatcccggg gcgtggaaat aacaaggatt tcccgtattc
     5821 cggccagcat cagcacggag atgggataat aaaccatcgg cttatcataa acgggcagca
     5881 attgcttgct gacggaaagc gtaacgggat gcagacgcgt gccgcttccc ccggccagaa
     5941 caataccctt catatcaaat tcctagccat tggttccaag acgttccagg cggtattccc
     6001 cggacaggat gccccgccac cattcctcat ggtccagata ccactgaatg gtctttctga
     6061 atccggaaga atggtcctgg cgcggagtcc accccaattc cctccgtatt ttggaagcgt
     6121 caatcgcata gcgcaggtca tggcccggcc tgtcctgcac aaaggagatt tgctcccggt
     6181 agctccggcc gtccggacgg ggccgcagtt catccagatg ggaacacagc agttccacca
     6241 gctccagatt ggttttctcg ttattgccgc cgatgttgta cgtttccccc ggttttccgc
     6301 aggaaacgac cgtcaacagc gcctcgcagt gatcccccac atacagccag tcccgcacgt
     6361 tttccccctt gccgtataca ggaatgggtt ccccgcccag cgctttcagg ataacgacgg
     6421 gtatcagctt ttccgggaac tggtaagggc cgtaattgtt ggaacagttg gtgatcagca
     6481 cgggcagccc gtacgtatcg tgccaggcgc gcaccaggtg gtcgctggag gccttgctgg
     6541 cggaatacgg ggaatggggg cgatacggcg tggactccgt gaacaggcct tcctttccca
     6601 gggagccgta cacttcatcc gtggaaatgt ggtggaagcg gaaacgctcc tttttctctc
     6661 cctccaggga acggtaatat tccagggcgg cctgaagcat ggaaaaagtg cccatgacgt
     6721 tggtggtcat aaaatttccc ggatcgtcaa tggaacggtc cacatgggat tccgccgcca
     6781 ggtgcatcac ccagtccgga gcgtactccc gcaaagtgcg ccgcatcagg gaagcgtccc
     6841 ggacgtcggc gtgcagaaag cggtatgccg gagaatccgc cgagccgtcc agtgaatgga
     6901 tgttgccggc ataggtcaga gcgtcaatat tcaggacttc atggccgcgc tccagcagca
     6961 gcctgaccag attggagccg atgaatccgg cgccgcccgt aacgataact ttcatagcac
     7021 tgttttcagg gaaagatgcg gcgccatcat acagcagcgg cgtttttttt caaaacaaat
     7081 ccgcccatgc cgcgggaacg tggcggcata ggcgggaaaa agcgggttcc gtaaccgctg
     7141 agacggctag cagctcagct cccggcaaag gttgatgata tcctggttca cggagtactg
     7201 ctgcccggct acggaatcca gggaggcata gccgtactgg ccgtcatgat acaccatgat
     7261 ctggttgatg tccccgttgt tcagagcttc cacggcgcgg gtggcaaaac gggtgcccat
     7321 caggcggtca cgggcggtgg gggaaccgcc gcgctgcaca tggcccagca cggtcaggcg
     7381 ggtatccatg ccggcgcgtt ccgtcagcca gcgggtcagg tactgcgcca cgcgggtgcc
     7441 ttccgccacc acggcaatga tgcagcttcc ttcctcattg atgacaggct ggaggcgctt
     7501 gtaaatggat tccagatcat acggaatttc agggacaatg cagatatccg ccgcgctgca
     7561 aagagcggtg gtcatcgcca gatagccgca gtcccggccc atcgtttcaa tcacgaaagc
     7621 gcggtgatgg gaacgggccg tatcacgaac ggaatcaatg caatccagaa tcacgttctg
     7681 ggccgtatcc acgcccaggc agtagtccgt tccggcaatg tcgttgtcaa tcgtagccgg
     7741 aataccggca aaaggcactt caaaatcatt gaaaaagtcg ttcagggcgc ggaaggaacc
     7801 gtccccgccc atgatgatga gcttgtcgat gttgcgttcc ttcagatgtt cgtaggcctg
     7861 cttgcggaat tcgtagtcga aaaagcgctt ggatcgtgag gaacggagga gagttccgcc
     7921 cctgtagatc atatcgttgg tcagttcccg ggtggcttcc ttgatttttc catcgatcag
     7981 cccttccaag ccgtcataaa caacgtacgg gttcatccca agctggcggg catgatccac
     8041 tgccgccttg atcgccgggt tcattccggc ggcatcaccg ccagatgtca taatggctat
     8101 tccactcata agtaataagg ttaacttgtc cggggggaaa tgttaccggg cggaacaaat
     8161 aatgcaagcg cggagttttt actggcgcaa taaacggcaa cacttcatga tgcggaggca
     8221 tgaacgacac tgcagcagcc attctgaaag ccacggccgc cctccgggac ggcacggaga
     8281 agctccggtt cgaatccccg gtccatgtta cctacaaccc tctcacctat gcatgggggc
     8341 cgcatgaaca gtatgtgcgc acctacggaa acggggaaaa gagccatctg ttcctgggca
     8401 tgaatcccgg ccccttcggc atggcccaga caggcgtccc cttcggggaa gtggacgccg
     8461 tcgtcaactg gctgcacatt cgcggagaag tcgggcggcc ggaacatacc caccccaaac
     8521 gtcccgtgga gggtttcggc tgccccaggt cggaagtcag cggccgccgc ctctgggggc
     8581 ttttcgcgga agctttcgga actgcggaaa acttcttccg tcacaattac gtggccaatt
     8641 actgtccgct gatctggatg ggagccaccg gagccaacat tacgccggac aaactgccgg
     8701 cggaacagcg cgccgccgtg gacgcagtat gcatggaaca cctgctttcc ctcatcacca
     8761 tcctgaatcc ccacacgctg gtgggtgtgg gtgcctacgc cacgcagaag ctgcgggacg
     8821 ccgcctcccg gctccccggc aaaagcttca ccatcggcac gttgctccac ccaagccccg
     8881 ccagccccat cgccaacaag ctctggccgg aacaccccat ccagcagctt aaggaactgg
     8941 gcattttata aaaagagcgg aggaggtaga gtggaaagct ccgtgacatg gaaggaatca
     9001 ccagagcgac aggccggaaa tcggcagttc atcttgttct cctccaaatc tacatcgttt
     9061 tgaaggaata tccggccccc tttactggct tgatttgccc agggacacag ccttcctgac
     9121 ggaagaaaag cacgccggca tctaccggga cagagaagaa cttaaacgcc tccccacttc
     9181 caccacaaaa atcagcctcc ctccaaatca atcatcattc ttagactgaa aaccctccgc
     9241 tctcccccgc aggccttttt actggacagg gggaaaaggg ttccgtacag tttccgcgat
     9301 cttcaagcgt tccgaattta tggcaatttc agattacatc gtgaccattg gcctggaagt
     9361 ccactgccag atcaagacaa agagcaaaat gttctgctcc tgcgagaccg gctttggctt
     9421 tgaacccaat acgcgcgtgt gccccacctg cctggggctg ccgggcgccc tgcccgtcct
     9481 gaatgagttc gccattgaac gcacgctgct gaccggcctg atgctgggat gctccagccc
     9541 ggagatttcc caatgggacc gcaaaaatta tttctatccg gacatggcta aaaattacca
     9601 gacctcccag ctggatcttc cgctgtgcct gggaggggaa gtgcccctgt acccctggtc
     9661 ctatccgaat gacgtgatca aagccggcat cccccctttc cgcaccgtga agctgacccg
     9721 catccatctg gaagaagacg cggcgaagat tacccatcat gccaattatt ccctgatcga
     9781 ctacaaccgc gcggggtccg ccctgatgga aatcgtttcc gagccggaca tcgacacccc
     9841 ggaagaagcc tacgcctacc tcaagtccct ccagcagatt ttgaattacg gggatatctc
     9901 cgacgcggac atggaaaagg gccagatgcg gtgcgatgtg aatatttccc tgcgtcccca
     9961 cgggcagaag gaattgggcg ccaaggtgga aatgaagaac atcaactcca tgtccgccgt
    10021 ccgcagagcc cttcattatg aaatccagcg ccaggcggaa gaactggaca tgggcattcc
    10081 tcaatccagt ccacccgccg ctgggacgac gaacgcggag aaagcgtcgt catgcgaacc
    10141 aaggaagacg cgcacgatta ccgttatttc ccctgtccgg atctggttcc cgtacgcacg
    10201 gccccgctgg tggagaaagt gcgcgggcag attcccgaac tgcctcagga acggcagaaa
    10261 cgcttcatgg aagaatacgg cctgagcgag tacgacgcca acgtgctggt gggagacctg
    10321 gaactggcac gcttttttga agaggcggcg cggggaaccg ccagcggcaa aaaaatcgcc
    10381 aactgggtga ttaacaacat ttccgccgtg ctgaatgaaa aaggcatgcg cccgtctgaa
    10441 tgcccggtga aacccggcgc catccgggag ctgatcgcca ttattgacga cggcaccgtt
    10501 tccaacaacc aggccaagga cgtattcgcc aaaatgtggg atgagccggc cctcgccgca
    10561 gcgcaggccg ccaagctgct gggctttgaa aaggcggatt cctcttttct ggacggcatc
    10621 gtgcgggaag tcatttccgc caatccggac aaggtggcgg aaatacaggg gggcaatgaa
    10681 aagctcctga actggcttac cggccaggtc atgaaggccg ccaaaggcaa agccaacccg
    10741 aaaatcgtga cggaagcgct gaaaaaagcc ctttccatgg agtgaccata aacaaagagc
    10801 cgcttccctt gccgatgccg gctccttgcc cgcagggcat cacggtttga acagcttcct
    10861 gtttccggcc agggtgttcc atacctgctt cacttccccg gccagcgtct gcttcatcat
    10921 ggcaagggaa aagtccgccg cctggcccat actgatgtag ggaggcaggg caagggcgtc
    10981 cctgtccaca tgcgcgtcca gcagagcggc gcccggataa ttcaggaaca tgtccaccat
    11041 ctggtccacc tggctggatt tgtccaataa aaaccccttg atgccgacgg catccgccac
    11101 ggcggcaaaa gaggggttgt tcaggttgat ctgccacgga atcagcccgg ccgcctgcat
    11161 ttccaattgg atgaaatcca gacagtcatt gttatacacc acgattttca ccggcagcct
    11221 gtactggaca atcgtgatga gatcccccag cagcatggac aggccgccat ctccgcacag
    11281 ggcaattacc tgccgttcgg ggtattccat ctgcgcccca atagccatcg gcatggcatt
    11341 ggccatggag ccatgattga aggaagccag cgtcctcctt cccggcgtgg cgcacaggaa
    11401 cctggcgctc cagatacagg gggtgccggt atctaccgta aatacggcgt cggatgccgc
    11461 atgcctgttc agggcggtcg tgagctgttc cggccggatg ggagactcct tgtcatttcc
    11521 ttccatatag gcgttcatct ccttcacgtc cctggcgtgg cgtttcaggg cggcatccaa
    11581 atgcccggaa tccgtctttt cctgcaccat gttcagcaga gcttccgccg tgacggaaac
    11641 atccccgcaa atacccaggt ccaggcggca gcggcggccc agcacttcac cgcgcctgtc
    11701 aatctgcacg atttcaggtt tggtgggaat gaaattgaaa taggggaaat ccgtccccca
    11761 caacacgagc atgtcgcttt catgcatggc cttgtaggca tctccccatc ccagcagccc
    11821 cgtcatgccg atgcccaggg gattgtcatg ttcaaaatga tcctttcccc tccatgtgta
    11881 ggcaatcgga gctttcaggc ggtgcgcgag ccggacgacc ttgtcttccg ctcccgcgca
    11941 gccggcgccg cagaagaaag taatgcggcg gtggtcgtca agcatccgtg ccagaaggga
    12001 tacggattca tgctcaggaa caacattctc ccgcgtgtag gaaggaggat gcaccagatt
    12061 cttcatctcc gcaggggcgt ccgcaatgtc tccgggcaag acgacgacgc ctacgtcgcg
    12121 cctggcccac gcgtgctgaa tggcggacat caaaatggac ggggcctggg aagcttccga
    12181 aaccagttcc gcatatgcac tgcattcctt gaaaagctgt tccggatgcg tggcctggaa
    12241 atattccatg cctacctggc tctgcgggat gtggaaagca atggccagca ccggggcatg
    12301 gttccggtgg gcgtcaaaca ggccgttgat caaatggagg ttcccggggc cgctgctgcc
    12361 gcagcataca gccagattcc cgctcagctg ggcttccgcg ctcgcggcaa aagccgccac
    12421 ttcctcatgc cgcacatgaa tccattcaat ggtcttcctc ctcctcaaag cgtccgtaac
    12481 ggggttcagg ctatccccca caatgccgta aatccgctta actcccgcct tctccaaaat
    12541 ttcaacaatc tgatcggcta ccctgtacat gcagattaga caccagccaa cctccaacgg
    12601 attcattctt atgtgtcatc ccctccatct tttccgcacc ggaaaaaatg cctgaggatt
    12661 tcccctgata tcataaagcc gccgcctttt caggcagcgg cctatgaatt taccagttct
    12721 ctggtggaaa accgtcagga acggcggcgg cgcatcatca gaacggccag gcccaggatt
    12781 cccagagaag ccgaggccgg ttccggaacc tgaaggccgg caaaaccggc aatctgttcc
    12841 gcggaaagtt ttgtatccgt ccactgaatt tcaccccatg taagattggg attaatccag
    12901 ctttggatat cagagcgatt tccgttcatg ttgccgttgt aggacaacgt gtcaagcaag
    12961 gaaccattca catagacatc cacagactgg ctttggtctg cgccggtaac ggccaaagtc
    13021 acgttaagaa gacctccccc caaaacaacg gaagcttcag aaacgtctcc acggttttgg
    13081 gaaaaagagc cggtagaagt attcaagttc ccatctccca tgcccagctt ggcatctgac
    13141 gtcagataca aggcatttgt cccgtaactt tggcccacat tggtgccata atacccaaac
    13201 agcgtggtct gggttccttc cgttaaggaa gaagtatcca gccagaggga gatcgtgtaa
    13261 ttggaagcat aaaaattacc gccgtaagga atggaactgc caggaagggc actttgtgag
    13321 agacttccaa acgtcatgtc ttttcccaat gcaatacctt cggttgtcgt cgccgtaccg
    13381 gcaacgtaag acgttccggc cgatggttct aaagagccgg gagacgccaa cgccggaacg
    13441 gaacaacacg ccgcaatggc cattaatgct aatgtttttt tcattttctg tgaatgatgg
    13501 actgagtagc aatcagagag atattccccg ccctctgtat atcggattcc caatccgctc
    13561 tttttctccc ccacaggaaa gatgagaaca agctttttca atccgctaaa aaatataata
    13621 taattacctt ctatcactta tgaatataaa aaataaaacg cagaatagat tttttgtgga
    13681 ggttctgaag ttgctgtata g
//
