LOCUS       c00060_gnlPro..        15377 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CIIEBGGC_60.
ACCESSION   c00060_gnlPro..
VERSION     c00060_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 21:37:52
            Original ID  :: gnl|Prokka|CIIEBGGC_60
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15377
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15377
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4518:10504]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4519..10504
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15377
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15377
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             252..1460
                     /locus_tag="ctg60_1"
                     /transl_table=11
                     /translation="MEKLDDMKLTVLYIEYRNFFIDVLSRFYGFEKYDIYHYSEILNVD
                     ELCRNEALNWDMYLIEFWGKEKINWEYLSGNKCLSWTADLFDKYYDYWEWDILSSNEGI
                     FWNELLLNKYKSKLNWNLLSLNKSLPWSIDFINRYVDRLNWVNLSANLSLPWSDYLLEY
                     YENLWDWNLISANPSLPWTDDLIIKYMDRLNWAGLSMNPALPWSSEFIQKYKYNWIWGY
                     SSDWVMTDDIGLCGNSGIHWNEELIEMFDGFIDWGELSLNTGDMWNECLIDKYLCKLHW
                     EECWCPPLGMGGLSSNPSLPWSLDFVDKYKPYLNIKEICSNMSFPWREEDFRNNNGGII
                     NDCDKSYWKLLSMNEGLPWSVGVLYDNRCWFDWNLMKGNVKVYDNCLSVLEKEKMKFLL
                     ELV"
     CDS             1982..2578
                     /locus_tag="ctg60_2"
                     /transl_table=11
                     /translation="VVVVCNVLVAGCASGKVFDRVEKIPHRKVGLLLGTAPVTPWGTKN
                     LYFTYRIDAAVKLFHAKKVDYFIVSGDNHSTDYDEPTCMRDSLVACGVPDERIISDYVG
                     FRTLDLEVRCKAIFGQDSVTVISQSFHNERAIYLAGHNQIDAIAFNAQDVTSVWTTWLR
                     GHSRELLARVKIFIDLIIGKQPRFWGEKVKIPEIR"
     CDS             2654..4201
                     /locus_tag="ctg60_3"
                     /transl_table=11
                     /translation="MAALYPIGIQNFEKIRKEGYLYVDKTALIYQMVKTGSYYFLSRPR
                     RFGKSLLVSTLEAYFQGKEELFEGLAMEKLEQDWLEYPILHLDLNAERYSEASSLDSIL
                     QRHLNLWEDTWGKDEREKTLSDRFIGVIRRAKARSGRRVVILVDEYDKPLLQAIGDELL
                     QDEYRSILKPFYGVLKTMDGDIRFALLTGVTKFGKVSVFSDLNNLMDISMDDRYVEICG
                     MTETEIHAYMEQGVLDLTRNLQMDYEEVCMELKRRYDGYHFTHRSQGMYNPFSLLNTFA
                     KSDFGDYWFETGTPSYLVELLKHTDYDLYNMAHTETNADVLNSIDAVSRNPIPVIYQSG
                     YLTIKSYNPRFKIYTLGFPNQEVEEGFLNYLLPYYTSVNVIDTSFQLFKFIKEIESGDV
                     DAFLSRLQSFFADTPYELIRNLEVHYQNVLFIVFKLVGFYVKVEYRTSRGRIDLVLQTD
                     HYIYIMEFKLDGTTEEAMRQIEEKQYALPFASDERKLFKIGVNFDNETRNIAGWSVD"
     CDS             4519..6354
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg60_4"
                     /sec_met_domain="ILVD_EDD (E-value: 2.6e-218, bitscore:
                     715.1, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKNPLRSSYSTEGRRMAGARALWRANGMKEEQFGKPIIAIVNSF
                     TQFVPGHVHLHEIGQQVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIAD
                     SVEYMVNAHKADAMVCISNCDKITPGMLMASMRLNIPTIFVSGGPMEAGNLDGRALDLI
                     DAMIEAADDSISDEQVEKVERSACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTVVAT
                     HANRTRLFKKAAKMIVDNAFKYYRDGDDSVLPRSIATRQAFLNAMSLDIAMGGSTNTVL
                     HLLAVAHEAEVDFTMKDIDMLSRKTPVICKVAPSCSYHVEDVNRAGGIIGIMNELVKAG
                     LVDGSVKRADGLTLNEAIDQYCITSVNVTEEAINIYKSAPAHRFNLVLGSQESYYKELD
                     TDRATGCIRDVEHAYVKDGGLAVLYGNIAQDGCVVKTAGVDESIFRFAGPAKVFDSQDA
                     ACEGILKDQVVSGDVVVITYEGPKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSGG
                     TSGLSIGHISPEAAAGGAIGLVKDGDIIEINIPERTIHVKVTDEELAKRREAEEARGTK
                     AFTPPFRQRTVSKALKAYAKMVASADKGGVRIVED"
     CDS             6381..8081
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg60_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.4e-51, bitscore:
                     162.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LKHILVRHEQGATHAAQGYARVSGKVGVTVVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRRPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVDYEYQKVDYVRSYQPEPDIREERIEAAASLINNAKKPFCLVGQGVILGG
                     AEEELKEFLLKNDIPAGSTVLGLSALPSDFPLNKGMLGMHGNVGPNRKTNECDVLIAIG
                     MRFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERK
                     RPEWNAEFEPDEKEEYNKVIEKELYPTEGQLKMGEVVRKVSEATDNDAILVTDVGQNQM
                     MGVRYFKYKQTRSVVTSGGLGTMGFGLPAAIGAKLGAPDRTVCFFTGDGGIQMTIQELG
                     TIMQENLNVKIIVLNNNFLGMVRQWQELFFNERYSNTIMKNPDFVAIAKAFGIASRAVD
                     KREDLDEAIAEMLNHDGAYMLVANVETCGMVYPMVPAGGSVTNMILGDK"
     CDS             8094..8648
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg60_6"
                     /sec_met_domain="ALS_ss_C (E-value: 1.1e-18, bitscore:
                     56.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKQLYTVIIFSENTVGLLNQITVIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDTIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEDLIRKYNARILEMNEDCVVLEKSGHYDETQALFKELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLSAMEKKLQEKHV"
     CDS             8685..9416
                     /locus_tag="ctg60_7"
                     /transl_table=11
                     /translation="MEKNKVGEFHFVTESYLTDFRGRITIPMIGTYLLHAASCHAADRG
                     FGYNDMTERHTAWVLSRLAIEMTSYPAMSESVTLYTWVDEVGKLFTSRCFELVNGEGKT
                     FGFARSIWAAIDMETRRPTLLDVEGLSAYITDRPCPIEKPGKIAPVENNTSGEPYRVKY
                     SDLDVNGHLNSIKYMEHLLDLFDISLFREKEISRFEIAYQSEGKYGMELTLHNQEVSLD
                     KYNMAICNDGKAISRAAVTWI"
     CDS             9458..10504
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg60_8"
                     /sec_met_domain="IlvN (E-value: 1.2e-48, bitscore: 154.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.8e-44, bitscore: 140.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVMNFGGVDENVVTREEFPLEKAREVLKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRKGGKTWEKAVADGWVPGETLFDIEEACEKATIIQYLLSDAAQI
                     EVWPRIKKYLTPGKALYFSHGFGITYKERTNIIPPADVDVILVAPKGSGTSLRRMFLQG
                     RGLNSSYAIFQDATGKAWDRVIALGIGVGSGYLFETTFKKEVYSDLTGERGTLMGAIQG
                     LLLAQYETLRENGHEPSEAFNETVEELTQSLMPLFAENGMDWMYANCSTTAQRGALDWM
                     GPFHDATKPVFQKLYSEVACGNEAQRSIDTNSKPDYREGLEKELAALRESEMWRAGAVV
                     RKLRPENN"
     CDS             11006..14284
                     /locus_tag="ctg60_9"
                     /transl_table=11
                     /translation="MISVLLGAAGAIAANPTGPETMVVQQGNKVTGLVEDQMGPVAGAS
                     VVVKGTTIGTITDIDGKFTLDNVRRGAVIVISFVGLATQEITWNGQSILNVKLSDATQD
                     LDEVVVVAYGTAKKSTFTGSASVVKAEKLEKIMGSGFAEALQGMSAGVNVVNVQGNPGA
                     DARVEIRGIASMSGKADPLYIVDGMPYDGKLNQINPTDIESMTVLKDAAATSLYGSRAA
                     NGVVMITTKRGKSEKPRINFRGGWGTSDNAVKNPKKADPYQQLENTWYALYYDALLYDG
                     MNMQQAGDYASSQALTKQVKATKDSNGNLIYVTPFRHINENYVLHDGNGNPYMNPNLEY
                     VWDEDDWDVYKAIFSRKLRQDYSVDISGQANGGKTAYFFSGGYLDDQGYGNRQYYKRYS
                     FRTNLSTELFDWWKVAGSLSYSRHRQNLSGGASRAANFTTTLSSPWLRNEDNTGWVVSE
                     KTGERMYSYGKYTNNFFGAHILNNSGDYWDNPNDDSFDNNMGHILSAQVNTEFTLPFNL
                     KFRSALNIDDYWYRTMQYTSAVHGSGQTAPYGISILADGGYASRYNFNKRSTTWNNVLS
                     GEWMIGDHTISGLVGHEWYTWDSHYEQGWGEGIMELGKYELSNTTKNFGVSGGRDKYSL
                     LSFFGKVDYNFLNKYYLSASLREDGSSRFSSDHRWGTFWSTGGSWRISKEGFMEDLKWI
                     DNLSLRGSYGTTGNDKLIVRESNGKAGDEVLYGYQGTYESDDLYLKSGLKPSTYPTPDL
                     KWESNQQWNIGLDFSVFNRLSGTVEYYSRTSHDLLYYKELPLSAQVGSASGYNMNIGDL
                     RNSGIEITLNANILTTKDFRWDIDANMSTLKNEVTYLPTGPYTYSGTACTYKMEEGKSL
                     YEFIAPQYDGVNPETGVPGWLIRDGNGGWKRTEKQEEVTTDDFVYCGSAIPKVFGAITN
                     NFQFKGIDLSFMFYYSYGSKISDYTYKERIMNRPGVGVIQELVEDRWRQPGDADVLIPR
                     WSYNQYGATVKYADNFVFDNHYWRLRNLTLGYTLPKSLTRKALVENLRVYVTGNNLLTF
                     GPAKKRYTDPETGIMGNSYNGNAETDNGIQGSRRLYMVGIQITL"
     CDS             14303..15376
                     /locus_tag="ctg60_10"
                     /transl_table=11
                     /translation="MKRFINISFLSLVFAGMALTGCNDDLTTSSYVKVNDEDVLGNVSQ
                     LEKVLTSAYKQLYFNTDKGDRVYAGLPGFQMYVDASGADVISHTNMGGDQVTAYQYSNS
                     KTQADGNASKIWSMCYNVINRANIILTNVDAAAGDETQKKHIKGQALAMRGIQYFHLIQ
                     NYQQTYAIAKSKRGVILRTSSDDESHKGFSTVEEVYTQIVSDLTTAKTLLADYNPDDMW
                     LINSKICSGILARVYLVMQNWDGAYNEAKIVYDQHSQLMTREQYRSGFDDMISGNYAEV
                     VWAMKYTADNNLGGSTQFNFWYNQDASYGEGYADGPIYSFLDYFVDEQFVKLFEEKEDR
                     YQFWKRTNNANTEINTKW"
ORIGIN
        1 cacttatcaa aaaaagaaca tttccccatc cgttttcttt cgggcgagaa ctattttggt
       61 gcggttgccc tgtattttcg ctttctttct tgcaagttca agattttctt gataacttgc
      121 cactgtgttt cttctaaatc cgtacaatac ataattattt gaaacttagt aattaaaaat
      181 aattatttta gcagaaagag gaaacacttt atttatttca aactgtgaaa tttaaacagg
      241 ctctaattat tatggaaaag ttggatgata tgaaattaac tgtattatat attgaatata
      301 gaaatttttt tattgatgta ttaagtagat tttatggttt tgaaaaatat gatatatatc
      361 attatagtga aattttgaat gttgatgaat tgtgtagaaa tgaagcttta aattgggata
      421 tgtatctgat agaattttgg ggtaaagaaa aaattaattg ggaatatttg agtggaaata
      481 agtgtttgtc atggacagca gatctttttg ataaatatta tgattattgg gaatgggata
      541 tcttgtcttc taatgaggga atattctgga atgagttgct gcttaataag tataaatcta
      601 agttaaattg gaatttgttg agcttaaata aatcgttacc gtggtcaatt gattttataa
      661 atcgctatgt tgatagatta aattgggtta atttaagtgc taatctgtca ttgccttggt
      721 ctgactattt gttggaatat tatgagaatt tatgggattg gaacttgata agtgccaatc
      781 catcgttgcc ttggactgat gatttaatca ttaaatatat ggatcgttta aattgggctg
      841 gattaagtat gaatccagcg ttaccttgga gttctgagtt tatacaaaag tataaatata
      901 actggatctg gggatattca tcagattggg taatgaccga tgatataggt ttatgtggca
      961 attcgggtat tcactggaat gaggaattga tagagatgtt tgatggtttt attgattggg
     1021 gagagcttag tttaaataca ggagatatgt ggaatgaatg tttgattgat aaatatttat
     1081 gtaaattgca ttgggaagaa tgctggtgtc ctcctttggg tatgggaggt ctcagtagta
     1141 atccttcatt gccttggagc ttggactttg tggataaata taaaccttat ttaaatataa
     1201 aagaaatttg ttctaatatg tctttccctt ggcgtgaaga ggattttaga aataataatg
     1261 gtggaataat aaatgattgt gataaatctt actggaaatt attgagtatg aatgaaggtt
     1321 taccttggtc tgtaggagta ctatatgata atagatgttg gtttgattgg aatctaatga
     1381 aaggaaatgt gaaagtatac gataactgtt taagtgtttt agaaaaagaa aagatgaaat
     1441 ttttacttga attagtttga ttgaagtatc aaaaaatggt cgtggatgat tgggtaggat
     1501 agttatataa gtgacgaagc tgaagaaaag aatatgcgcc tatattttat agaaaagtct
     1561 attgctatgc taatacaagt aaagatcgtg tgttgaaaaa tatgacatcg tattttgggg
     1621 acagtgaaaa tattattagt taatacagtc tgcaaaattt atattactct gataggttgg
     1681 agcaatcgtt ctttgcaggg atgatatgtt ttatccggta atgattggtg aagacggaag
     1741 ctttcctgtc aaatgaaata tgacatgctt atggctttgg atatgtctgg aaataatacc
     1801 tttgctatat gccttttaca aaaatattcc taagaagaaa tagattgttt tattaggatt
     1861 gttattttgt tggtgacaat cctttataat aaaagagcaa gtctgtgaaa aaaagtaatt
     1921 caaagtaaga agaaaatcat acaattaacc attatttctg ctcatttctg tcataaacat
     1981 agtggttgta gtttgtaacg tgttggtggc aggttgtgcc tcaggtaagg tatttgacag
     2041 ggtggaaaag ataccacatc gtaaagtcgg tttgttgttg gggactgctc cggttactcc
     2101 ttggggaacg aaaaatcttt attttacgta tcgtattgat gcggcagtca aattgtttca
     2161 tgcaaaaaag gttgattact ttattgtaag tggtgataat cattcaacag attatgatga
     2221 gccgacttgt atgcgtgatt cgttagttgc ctgtggtgta ccggatgagc gaattatttc
     2281 ggattatgtc ggttttcgaa cgcttgattt ggaagtgcga tgtaaagcca tttttggaca
     2341 ggatagcgtt actgttattt cgcagtcttt tcataacgag cgtgcgatct atttggcggg
     2401 tcataatcaa atagatgcga ttgcattcaa tgcccaagat gtgacttctg tgtggacaac
     2461 ctggttgagg ggacatagtc gtgagctttt ggctcgggtt aaaatattta tagacttgat
     2521 tattggtaag caaccccgtt tttgggggga gaaggtcaag attccggaaa tccgatgaaa
     2581 atgtaatata ataagatact tattgataaa aaataagtta cctttgtctt gatagataat
     2641 ataaaaacgg tttatggctg cactttatcc tattggcata caaaatttcg agaagattcg
     2701 taaggagggg tatctctatg ttgataaaac agcgttgatt tatcaaatgg tgaagaccgg
     2761 gagttattac ttcctgagtc gtccgcgccg tttcggcaaa tcgttgttgg tttcgacttt
     2821 ggaggcctat tttcagggta aggaggagtt gttcgaggga ttggcgatgg agaagctgga
     2881 acaggattgg ttggagtatc cgatattgca tttggattta aatgcggaga ggtattcgga
     2941 ggcttcgtcc ttggatagta ttttgcaacg tcatttgaac ctgtgggaag atacatgggg
     3001 aaaagatgaa cgggaaaaga ctttgtccga tcgttttata ggggtgatcc gccgggcaaa
     3061 agctcgatcg ggaaggcgtg tggtcatttt ggtggatgaa tacgacaaac ctttgttgca
     3121 ggctattggg gatgagctgt tgcaggatga ataccgttct atattaaaac cgttttatgg
     3181 ggtgttgaag acgatggacg gtgatatccg ttttgctttg ctgacaggtg tgacaaagtt
     3241 cggtaaagta agtgtgttca gtgatttgaa caatttgatg gatatttcga tggatgatcg
     3301 ttatgttgag atttgtggta tgaccgagac ggaaatccat gcgtatatgg aacaaggggt
     3361 gttggatttg actcgtaatc tgcaaatgga ttatgaagaa gtttgcatgg aattgaaacg
     3421 ccgttatgat ggttatcatt ttactcatag gtcgcaaggc atgtacaatc cgttcagttt
     3481 gttaaacaca tttgcgaagt ctgactttgg agattactgg tttgagacag gtaccccctc
     3541 ttacttggtc gagctgttga agcataccga ctatgacttg tacaatatgg cacatacgga
     3601 aacgaatgca gatgtgttga acagtatcga tgccgtttcg cgtaacccga taccggttat
     3661 ttaccaaagt ggttatttga cgatcaaatc ctataatcct agatttaaaa tatatacatt
     3721 gggctttcca aatcaggaag tagaagaggg gtttctgaat tatttgcttc catattacac
     3781 ttctgtcaat gttattgata cttccttcca gctttttaaa ttcattaaag aaatcgagtc
     3841 tggggatgtg gatgctttcc ttagccggtt gcaaagtttt tttgccgata cgccatatga
     3901 attgattcga aatctggaag tgcactacca gaacgtcctg ttcatcgtct tcaaactggt
     3961 cggtttctat gtgaaggtgg aatatcgtac ttcccgtggt cgcattgacc tggtgttgca
     4021 aaccgatcat tacatttata taatggagtt taagttggat ggcacgacag aggaggcgat
     4081 gaggcagatc gaagagaagc agtatgcctt gccttttgcc tcggatgaac ggaaactttt
     4141 taagataggg gtgaactttg ataatgaaac acggaacata gccggttggt cggtcgattg
     4201 atgtagattt taataatact gttaaaatgc aagatgaacc gccctctttt attgataaat
     4261 gaaagaaaaa gtaagatttt tcttttaaat cctttgctcg tacaaattat tattctacat
     4321 ttgcagcgtc aaacaaaata aagacgataa gaaaagatga tgaacaatgt attacatatt
     4381 attctcgtgg tggtccttct agtcattagt aggtaaggag aaaggtgtgt aagaagttgt
     4441 gaagtcgtaa aagatatttc ttaagccttt ctccatatag agaagggctt ttttattgac
     4501 taaaagataa aaacagatat gatgaagaat ccgttaagaa gctcctatag cacagaaggc
     4561 agacgtatgg ccggagcccg tgcattatgg cgtgccaacg gcatgaaaga agaacagttc
     4621 ggtaaaccga tcattgccat tgtgaattca tttacccagt ttgtaccggg ccatgtgcat
     4681 ctacacgaga tcggacagca ggtaaaagcg gaaatcgaaa agctcggttg ctttgccgca
     4741 gaatttaata cgatcgctat tgatgacggt attgctatgg gacacgacgg aatgctttat
     4801 tctctgcctt cccgcgacat cattgctgac agtgtggaat atatggtgaa tgcgcataag
     4861 gctgatgcaa tggtttgtat cagtaactgc gacaagatta ctccgggtat gctgatggcc
     4921 agtatgcgtc tgaatattcc gacaatcttt gtatccggcg gtccgatgga agccggtaat
     4981 ctggacggac gtgcactcga tttgatcgac gccatgattg aagcggctga cgattctatc
     5041 agcgatgaac aagtagaaaa ggtggaacgt tccgcttgcc cgacctgcgg ttgctgttct
     5101 ggtatgttca cggctaactc tatgaactgt ctgaacgaag cgattggatt ggctcttccc
     5161 ggcaacggaa cagttgttgc aacacatgcc aaccgtaccc gcctgttcaa aaaagccgcg
     5221 aagatgattg ttgataatgc ctttaaatat tatcgtgacg gcgatgattc cgtattgcct
     5281 cgcagtattg ccacccgtca ggcctttctg aatgctatgt cgctggatat tgccatgggg
     5341 ggatcgacga atacagtcct tcacctgttg gccgtggctc atgaagcgga agtcgatttt
     5401 acaatgaaag acatcgatat gctttcacgc aaaacaccgg ttatctgtaa agtggctccg
     5461 agttgttctt atcatgtgga agatgtgaac cgtgccggag gtattatcgg tattatgaat
     5521 gagctggtaa aagccggtct ggtggacggt tccgtgaaac gtgcggatgg tctgactttg
     5581 aatgaggcta tcgaccaata ctgcattacc tctgtaaatg taacggaaga agcaatcaat
     5641 atttataaaa gtgctccggc ccaccgtttc aatctggtgc tcggatcgca ggaaagttat
     5701 tataaagaac tggataccga ccgtgcaacc ggatgtatcc gcgatgtgga acatgcttat
     5761 gtgaaagacg gcggtctggc tgttctgtat ggaaatattg cacaggacgg ttgtgtggtt
     5821 aaaacagccg gggtagatga aagtatcttc cgttttgccg gccctgccaa agtattcgat
     5881 tcgcaggatg ccgcttgcga aggtatcctg aaagatcaag tcgtctccgg cgatgtcgtc
     5941 gttatcacct atgaaggtcc taagggtggt ccgggtatgc aggaaatgtt gtatcctacc
     6001 tcttatataa agagtaaaca tctgggtaaa gaatgtgcgt taatcacaga cggacgcttc
     6061 agcggtggaa catcgggttt gtcaatcgga catatttctc ccgaagcggc tgcaggcgga
     6121 gcgattggct tagtgaaaga cggcgatatt atcgaaatta atattcccga aagaaccata
     6181 catgtaaagg tgacagacga agaactggcc aaacgccgtg aagcggaaga agcccgcgga
     6241 acaaaagcct ttacacctcc tttccgccaa cgtacggtat cgaaagcact gaaagcatat
     6301 gcaaagatgg ttgcttcggc cgataagggc ggtgtacgaa tagtagaaga ttaataaaca
     6361 ccaaatacta tattttagag atggacaaac aaaagataac cggttcggaa gctttgctga
     6421 aagcgctgat cgctgaagga gtagatacta tcttcggtta tccgggtggg caggcgatac
     6481 caatttacga tagtttatac gattacagag atcagttaaa acatattctg gtgcgccacg
     6541 aacaaggtgc aacacatgct gcacagggat atgcccgtgt ttccggaaaa gtgggagtaa
     6601 cggtggttac ttcgggtccc ggggcaacca ataccatcac tggtattgcc gatgcgctga
     6661 tggacagtac accgatggtg gtgattgccg gccaggttcc gtctccgctg cttggaacag
     6721 atgctttcca ggaagttgat gtgatcggta tcacacaacc gattaccaaa tgggcttacc
     6781 agatacgccg cccggaagaa attgcttggg ccgtttcccg tgctttctat atcgcatcga
     6841 ccggtcgccc gggacctgtg gtactggatt tggcgaaaga tgcacaggtg ggtttggtag
     6901 attatgagta tcagaaagtg gattatgttc gtagttacca acctgaaccg gatatcaggg
     6961 aggaacgtat cgaggcggct gcttcattga taaataatgc caaaaagcca ttctgtctgg
     7021 tagggcaggg ggttatcctg ggaggagctg aagaagaact gaaagaattc ttgttgaaaa
     7081 acgatatacc agccggttct accgtattgg gcttgtctgc attaccttcg gacttcccat
     7141 taaataaagg tatgttgggg atgcatggaa atgtcggacc gaaccgcaag acaaacgaat
     7201 gtgacgtgct gattgctatc ggtatgcgtt tcgatgatcg cgtaaccggc gacctgaaga
     7261 cttatgccaa gcaggcaaag attatccacc tggatatcga caattcggag atcggaaaga
     7321 atgtgccggt cgacgtgaaa gtgctgggaa atgccaagca tacgattccg atgattacgg
     7381 ctttactgga agaacggaag cgtccggaat ggaatgctga attcgaaccg gatgaaaaag
     7441 aggaatataa taaggtaata gaaaaagaac tctatcctac cgaaggccaa ctgaaaatgg
     7501 gcgaagtagt ccgtaaggtt tccgaagcaa ccgataatga tgcgattctg gttacggatg
     7561 taggtcagaa ccagatgatg ggtgttcgct atttcaaata taaacaaaca cgcagcgtag
     7621 ttacttcagg aggtttggga acgatgggct ttggccttcc cgccgccatt ggagcgaagc
     7681 tgggagcgcc tgaccgtacg gtctgtttct ttaccggcga cggtggtatc cagatgacta
     7741 tccaggagtt gggaactatc atgcaggaaa atctgaatgt aaagatcatc gttcttaaca
     7801 acaatttcct gggaatggta cgccagtggc aggagctgtt cttcaacgaa cggtattcga
     7861 ataccatcat gaagaatccg gattttgtag cgatagccaa ggcttttggt attgcttccc
     7921 gtgcggtaga taaacgggaa gacttggatg aggcgattgc tgaaatgttg aatcacgatg
     7981 gtgcctatat gttggttgcc aatgtggaaa cttgtggtat ggtatatccg atggttccgg
     8041 ccggaggaag cgtgacaaac atgattttgg gtgataagta aggaggagaa actatgaata
     8101 caaaacaatt atataccgtt attatctttt cggaaaacac tgttggtctt ctgaatcaga
     8161 taactgttat ctttacgcgc cggcaactga acattgagac gctttctgtt tctccctctg
     8221 ctataaaggg aatacataag tttacaatta ctacctttgc cgacgaggat acgatcgaca
     8281 aggtcgtaaa acagatcgac aagcgtgtgg atatcctgaa agcctattat aatacggatg
     8341 aagacctggt ttaccaggaa atcgctcttt ataaactgag taccgaactc tttatcaaga
     8401 tggggacggt tgaggatctg atccgtaagt acaatgcccg tatccttgaa atgaatgagg
     8461 attgtgtggt gttggaaaag agtggtcatt atgatgagac acaggctttg tttaaagaat
     8521 tgagtgagac gatcggtgtc ctgcaattta tccgttccgg acgcgttgct ataacgaaga
     8581 gtaaggtaga acgtctgagc gacatgttat ctgcaatgga aaagaagttg caggaaaaac
     8641 atgtctgaga ataataagga aacattttgt aaataaagta aattatggag aagaacaaag
     8701 taggagaatt tcatttcgta acagagtctt atctgacgga cttccgggga cgtattacaa
     8761 tccctatgat cggaacttat ttgttgcatg ctgcttcttg ccatgccgcc gaccgtggat
     8821 tcggatataa cgatatgacc gaaaggcata ccgcctgggt tctttcccgt ctggctatcg
     8881 agatgacttc ttatcctgcc atgtctgaat ccgtaacttt atatacctgg gtggatgagg
     8941 tcggtaagtt gtttaccagc cgttgctttg aactggtgaa cggcgaaggc aagacctttg
     9001 gctttgcccg ctctatctgg gcggctatcg atatggaaac ccgccgcccg accttgctcg
     9061 atgtggaggg cctgagtgct tatatcaccg accgtccctg tccgattgaa aaaccgggta
     9121 aaattgctcc ggtggaaaac aacacttccg gcgaacctta ccgtgtgaag tatagtgacc
     9181 tggacgtaaa cggccacctg aacagtatca aatacatgga acacctgctc gacttgttcg
     9241 atatcagtct gttccgagaa aaagagataa gccgtttcga aatagcttat cagtccgaag
     9301 gaaagtatgg gatggagctg actctccata accaggaagt atccctcgat aaatataata
     9361 tggcaatctg taacgacggc aaagccatca gccgcgctgc cgttacctgg atctgaaaaa
     9421 caaattattt tatatacatt ttaatagtaa aaagaaaatg gcagtaatga attttggcgg
     9481 cgttgacgaa aacgtagtaa cccgcgaaga atttccgttg gaaaaggcaa gagaagtatt
     9541 gaaagacgaa acaatcgctg taataggtta cggcgtacaa ggtcctggcc agagcctgaa
     9601 cctgcgcgac aacggtttta acgtaattgt aggacaacgt aaaggtggta agacctggga
     9661 aaaggccgtt gctgacggtt gggtaccggg cgaaacactg ttcgatatcg aagaagcatg
     9721 cgaaaaagca actatcatcc agtatctgct ttcagatgct gctcagattg aagtttggcc
     9781 gcgcatcaaa aaatacctga ctccgggtaa ggctttgtat ttctctcacg gattcggtat
     9841 cacttacaaa gaacgtacaa acatcatccc tcctgctgat gtagacgtaa tcctggttgc
     9901 tccgaaaggt tcaggtactt cactgcgccg tatgttcttg cagggtcgtg gtctgaactc
     9961 aagctacgca atcttccagg atgcaacagg caaagcatgg gatcgcgtga ttgcactggg
    10021 tatcggtgtt ggttctggtt acttgtttga aacaacattc aagaaagaag tttattctga
    10081 cctgaccggc gaacgtggta ctttgatggg agctatccag ggattactgt tggctcagta
    10141 cgaaactttg cgtgaaaacg gtcacgaacc ttctgaagca ttcaatgaaa cagtagaaga
    10201 actgactcag tcattgatgc cgttgttcgc agaaaacggt atggactgga tgtatgcaaa
    10261 ctgttcaaca actgcacagc gtggtgcttt ggactggatg ggcccgttcc acgatgctac
    10321 aaaaccggtg ttccagaagt tgtatagcga agttgcctgc ggtaacgaag cacagcgttc
    10381 tatcgacaca aacagcaagc ctgactatcg tgaaggtctg gaaaaagaac tggctgctct
    10441 tcgcgaaagt gaaatgtggc gtgcaggtgc tgttgttcgt aaacttcgtc ctgaaaacaa
    10501 ctaataaatg gtgatacatt aatagttaaa cattttgtga tataaaaacg gcaatccggc
    10561 ttttcgggtt gccgtttttt tatggtttat gtaatgcgtt aatggttaaa aaatgttttt
    10621 gattgcaact gttattgatt tttcatccca atatgtatgt cattgtttga atgtggattt
    10681 tagataaaaa aatcaattaa atggtggtta aaatatattt attagagcaa taaatataca
    10741 taattatgct tgtattaaat aatgataagt tatatttgct gatggagata ctgtagtttg
    10801 tagagtggaa atatagaagg atgttgtgtg taatgatcag tatatctttg ttttagttaa
    10861 ctttatttta ttgaaatgta tgccagtcac ttttatctta gaaaagtgta acctctaatg
    10921 aaatgaacgc tattgtgatt aattttattt aattaaagac ttgaatttag ctatgtggac
    10981 caactcaaaa ctaattagat cactaatgat ttctgtatta ttaggtgcgg caggtgcgat
    11041 tgctgccaat cctacaggtc cggaaacgat ggtagtacaa cagggtaata aggtaaccgg
    11101 cctggtagag gaccagatgg gacctgtcgc cggagcttct gttgtagtga aaggaaccac
    11161 tatcggtacg ataaccgata tcgatggaaa gtttacgctg gataatgttc ggcggggagc
    11221 ggttattgtt atttcctttg tcggcctggc cactcaggag atcacttgga acggacaatc
    11281 tattttaaat gtaaaattaa gtgatgcgac acaggacctg gatgaagtcg ttgtcgtagc
    11341 ctatggaacg gctaagaaat caaccttcac cggatcggcc tccgttgtaa aagctgaaaa
    11401 actcgaaaag atcatgggct ccggctttgc ggaagcattg caggggatga gtgccggtgt
    11461 gaatgttgtg aatgtacagg gtaaccccgg agctgatgcc cgtgtggaga tccgtggtat
    11521 tgcttccatg tccggaaagg ccgatccgtt atatattgtg gacgggatgc cttacgatgg
    11581 aaaactgaat cagatcaatc ctacggacat agaatcgatg acggtgctga aggatgcggc
    11641 ggccacttcg ctctacggtt cgcgtgcagc aaacggcgtc gtaatgatta caaccaagcg
    11701 gggtaaatca gaaaaaccgc gtattaactt ccgcggaggt tggggtactt cggataatgc
    11761 tgtcaagaat ccgaaaaaag ccgatccgta ccagcagctg gaaaatacct ggtatgcctt
    11821 gtattatgat gcccttcttt atgacggcat gaatatgcaa caggcgggcg attatgcttc
    11881 gtcgcaggca ttgaccaaac aggtaaaggc tacaaaagat tcgaatggta atctgattta
    11941 tgtcactccg ttcagacata tcaatgaaaa ttacgtattg catgacggca atgggaatcc
    12001 ttacatgaat cctaatctgg aatatgtctg ggatgaagat gattgggatg tctacaaagc
    12061 tatcttctcc cgtaaactgc gccaggatta tagtgtggat ataagtggtc aggccaatgg
    12121 tggaaaaaca gcctatttct tctccggcgg ttatctggac gaccagggat atggtaaccg
    12181 gcagtattat aaacgttatt ctttccgtac caacctgagt acagagttgt tcgattggtg
    12241 gaaagtggcc ggtagccttt cttattcgcg tcatcgccag aacctttccg gtggtgccag
    12301 ccgtgcggct aactttacga cgactttgtc ttcaccctgg ttacgtaatg aagataatac
    12361 cggttgggtc gtttctgaaa aaacagggga acggatgtac agttacggta aatataccaa
    12421 taacttcttt ggtgcccata tcctgaataa ctcgggtgat tattgggata atccgaacga
    12481 tgacagtttc gataacaata tggggcatat cctgtctgct caggtaaata cagagtttac
    12541 tcttcctttc aacctgaaat tccgttcggc tttgaatatt gacgattact ggtatcgtac
    12601 catgcaatat acttccgccg tacatggcag cggacagact gcaccttatg gtatttctat
    12661 actggcagac ggtggttatg ccagccgtta taatttcaat aaacgttcca ccacctggaa
    12721 taatgtattg tctggtgaat ggatgattgg tgaccatacg atttcaggtc tggtcggaca
    12781 tgagtggtat acctgggact cccactacga acaaggttgg ggtgaaggta tcatggaact
    12841 gggtaaatat gaattatcga ataccaccaa gaacttcggt gtttccggcg gacgtgataa
    12901 atactctctg ctttcgttct ttggtaaggt cgattataac ttcttgaata agtattactt
    12961 gtccgcttca cttcgtgagg atggttcttc ccgtttcagc tccgatcatc gctggggtac
    13021 attctggtcg acaggcggtt catggcgaat atcgaaagaa ggttttatgg aagacctgaa
    13081 atggattgat aacctttcgt tgcgtggtag ttacggtacg actggtaatg ataagctgat
    13141 cgtgcgtgaa tcgaatggta aggcagggga tgaagtcctt tacggatacc agggtactta
    13201 tgaaagtgat gacctgtatc tgaaatccgg tttaaaacca tctacctatc cgacaccgga
    13261 cttgaagtgg gaaagtaatc agcaatggaa tatcggttta gatttttccg tattcaaccg
    13321 acttagcggt acagtggaat attattcccg tacttcccat gacttgttgt attataagga
    13381 actgcctctc tctgcccagg ttggtagtgc atccgggtat aatatgaata tcggtgacct
    13441 gcgtaatagc gggattgaaa tcacattgaa tgcgaatatc cttacaacga aagatttcag
    13501 atgggatatc gatgccaaca tgagtacgct gaaaaatgag gtgacttatt tgcctacagg
    13561 tccttacact tattctggta ccgcctgtac ctacaagatg gaggaaggca agtctctgta
    13621 tgaatttatc gctccccagt acgacggtgt taatccggaa accggagtac ccggctggtt
    13681 gatccgcgat ggtaacggcg gttggaaacg tacggaaaag caggaagaag taacgacaga
    13741 cgattttgtg tactgtggct ccgcgattcc caaagtgttc ggtgctatca ccaataactt
    13801 ccagttcaaa gggatcgacc tgtcgttcat gttctattat tcttatggtt ccaaaatatc
    13861 ggactataca tataaagaac gtatcatgaa ccgtccgggt gtcggtgtga tacaggagtt
    13921 ggttgaggac agatggcgtc agccgggcga tgcggatgtg cttatcccac gttggtcgta
    13981 caaccagtat ggcgcgacgg taaaatatgc agataacttc gtattcgaca accactactg
    14041 gcgtctgaga aacctgacat taggctatac gctgcctaag agccttaccc gcaaggccct
    14101 ggtagaaaac ctgcgtgttt atgtaaccgg taataacctg ttgactttcg gtcctgccaa
    14161 aaaacgctac acagaccccg aaacaggtat aatgggtaac agttataacg gtaatgctga
    14221 aaccgataac ggtattcagg gttcgagaag actgtatatg gtcggtattc aaatcacatt
    14281 gtaaacgtaa aaaatgatat ttatgaaacg atttataaat atatccttcc tgtccctggt
    14341 ttttgctggt atggccctga ccggatgtaa cgacgacctg acaaccagct cctacgtgaa
    14401 agtaaacgat gaagatgtac tggggaatgt ctcccagttg gaaaaagtat tgacttcagc
    14461 ctataagcag ctgtatttta atactgataa aggagaccgt gtgtatgccg gtcttcccgg
    14521 attccagatg tatgtcgatg cgagtggtgc cgacgtgatc agccatacca atatgggagg
    14581 tgatcaggta acagcatacc agtattccaa ctcaaaaaca caggctgacg gaaatgcctc
    14641 aaaaatctgg tcgatgtgct ataatgtgat caaccgtgcc aatatcatcc tgaccaatgt
    14701 ggatgccgcc gccggtgatg aaacacagaa aaaacatatc aaaggccagg cgttggcgat
    14761 gcgtggaatc cagtatttcc atctgatcca gaattaccag cagacgtatg cgatagctaa
    14821 aagcaagcgt ggggtgatcc tgcgtacctc ttccgatgat gaatcccata aaggtttttc
    14881 tactgtagag gaagtctata cccagattgt gtccgacctg acgacggcta aaacattgct
    14941 tgccgattat aatccggacg atatgtggct gatcaactcc aaaatatgtt cgggaatcct
    15001 ggcccgtgtt tatctggtga tgcagaactg ggacggcgct tacaatgaag ccaagatcgt
    15061 ctacgaccag cacagccagt tgatgacccg cgaacaatac cgttccggtt tcgacgatat
    15121 gatctccggc aattatgcgg aagtggtatg ggccatgaaa tataccgccg ataataacct
    15181 gggcggtagt acgcagttca atttctggta taaccaggat gccagctacg gcgagggtta
    15241 tgccgatggt cctatctact cgttccttga ctacttcgtg gatgagcagt ttgtgaaact
    15301 atttgaagaa aaagaagacc gttaccagtt ctggaaacgt acgaacaatg cgaatacgga
    15361 aatcaataca aaatggg
//
