LOCUS       c00111_gnlPro..        11604 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EBIJBGDG_111.
ACCESSION   c00111_gnlPro..
VERSION     c00111_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 15:58:09
            Original ID  :: gnl|Prokka|EBIJBGDG_111
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11604
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11604
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3321:9403]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3322..9403
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..11604
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11604
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             2..733
                     /locus_tag="ctg111_1"
                     /transl_table=11
                     /translation="KKNLFFLFALICSMSLFTACSDDDDDKIKDPVIGTWKVPAVELDE
                     NNSVIGGSVFMTWEAPEDTYLSFLPVSAIPSLAIQMGSVILPQVLQDVTLSADGNIVAT
                     YSSAGIDLSPVWETSPADYATFKLQGNGKMLLFLNLEKIIADANTKADITTVISQLLEL
                     VKNGIPVNYALSNNNEEVKIFIDKELMTTIAAMGPAIAELIPDDPDALGSFGPMIKAIL
                     GDLPTAMSKTTKFELGLNLKK"
     CDS             880..2160
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg111_2"
                     /sec_met_domain="SDH_alpha (E-value: 1.8e-62, bitscore:
                     200.7, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKTERQQIIDLVKSEVVPAIGCTEPIAVALCVAKAAEVLGRHPE
                     KITVLLSANILKNAMGVGIPGTGMIGLPIAVALGALIGKSEYQLEVLKDCNPDAVEEGR
                     RFIDEKRIHIALKDGIKEKLYVEVCCEVGDEKSTAIIAGGHTSFVYMARNGEVLLNKQA
                     VASTEKEEGALDLSLRKVYDFALTAPLDEIRFILETARLNKAAAESSFEGDYGHGLGKI
                     LRGTYEHKVMGDSVFSHILSYTSGACDARMAGAMIPVMSNSGSGNQGISATLPVLIYAE
                     ENGKSEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGTYEQVA
                     YAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAIMAMENRCVTSVEGIIDEDVDQ
                     SIRNLTKIGSKGMNETDKLVLEIMTSK"
     CDS             complement(2260..2832)
                     /locus_tag="ctg111_3"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYSIENGEKDFEEEAPVEHPFQFISGLGMTL
                     EPFEAQIKDLQIGDKFDFTIPASEAYGEYDDDHVIDLPKEIFMIEGEFDSDRVVEGAVI
                     PLMTSEGQRINGSVVEVKEDIVVMDMNHPLAGCDLNFTGEVVESRLATNEELAEVARMM
                     GGGCGSCGCGDCGDGCGDHECGGGCCH"
     CDS             3322..5124
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_4"
                     /sec_met_domain="ILVD_EDD (E-value: 2.6e-219, bitscore:
                     718.4, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKKLFEDAARLIVENAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVRRVDGMTLAEAIDRYSITSSNVCKEAIKKYSSAAAGKFNLVLGSQNASYKELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARLMTPVTRNRE
                     VSKALKAYASMVSSADKGAVRLID"
     CDS             5216..6967
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.5e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAVQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAERPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             7000..7560
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_6"
                     /sec_met_domain="ALS_ss_C (E-value: 6.1e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             7557..8309
                     /locus_tag="ctg111_7"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYIAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             8360..9403
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_8"
                     /sec_met_domain="IlvN (E-value: 3.9e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.5e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIVMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(9465..11378)
                     /locus_tag="ctg111_9"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQLLLRMEYEYEKEEFKRQTENMG
                     VARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRDRATALEIQI
                     NSELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIAIRKADRVVLAGD
                     HCQLPPTIKCHEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGE
                     LEAAPEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEADLLLSELKIYINR
                     IGGSRILEEKIDFGIISPYKAQVQYLRNKIKADASLKPYRSLFTVNTVDGFQGQERDVI
                     FISLVRANEEGQIGFLNDLRRMNVAITRARMKLVILGEAETLKHHGFYRKLLEFIQNIG
                     NQ"
     CDS             11493..11603
                     /locus_tag="ctg111_10"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLRRPMTLAEKIL"
ORIGIN
        1 gaaaaagaat ttgttttttt tatttgcgtt gatttgctct atgagtttgt tcactgcttg
       61 tagtgatgac gacgatgata agattaaaga cccggttatt ggtacttgga aagttccggc
      121 tgttgaattg gatgaaaata attcggtgat cggaggtagt gtttttatga catgggaggc
      181 acctgaggac acatatctat catttttgcc ggtaagtgct attccgtcgt tagctataca
      241 gatggggtct gtgatattgc cgcaggtatt gcaggatgtt actttgagtg ctgacggtaa
      301 tatagtggcc acttattctt ctgcagggat agatctttct ccggtatggg agacttcacc
      361 ggcagattat gcaaccttta aattgcaggg gaatggtaaa atgttgcttt tcctgaatct
      421 ggaaaaaata atagccgatg ctaatactaa agctgatata actactgtta tatctcaatt
      481 gttggaactt gtgaagaatg gaatccctgt gaattatgcg ttgtctaata ataatgaaga
      541 agtgaaaatc tttattgata aagaacttat gactactatt gctgctatgg gaccggcaat
      601 tgcagaattg attcctgatg atccggatgc attaggtagt tttggtccta tgataaaagc
      661 tatattggga gaccttccga ctgcaatgtc aaaaactaca aagtttgaat tgggtttgaa
      721 tttgaaaaag taatctaatt tagacaggaa gataacaact taagataggg aatcccacta
      781 ttaagcaatg tcttaatagt gggatttatt ttattccttc tattccttct attatagaat
      841 aaaatacatt acctttgtct gcatctaaat tgaataaata tgacaaaaac ggaaagacaa
      901 cagattattg atttggttaa atccgaggtc gttcctgcta taggttgcac agaacctata
      961 gctgtggcat tgtgtgtggc aaaagctgcg gaagtattgg gcagacatcc ggaaaagata
     1021 acggttcttt taagtgccaa tatcttgaag aacgcgatgg gcgtaggaat tcccggtaca
     1081 ggaatgattg ggctgcctat tgcagtagcg cttggtgcct taatcggtaa atcggaatat
     1141 caactggagg tattgaagga ttgtaatccc gatgccgtgg aagaaggaag acgttttata
     1201 gatgaaaagc gcatccatat agcactgaaa gatggcatta aagagaagct ttatgttgaa
     1261 gtttgttgtg aggtcgggga tgaaaagtcc actgctatca ttgcaggtgg acacacttcc
     1321 tttgtataca tggcacgcaa tggggaagtg ctgttgaaca agcaggctgt tgcaagcaca
     1381 gaaaaggagg aaggtgcgct ggatttaagc ttgcggaaag tctatgattt tgctttgacg
     1441 gctccgttgg acgaaattcg ttttatcctc gaaacggccc gtctgaataa ggctgccgca
     1501 gaaagctctt ttgagggtga ttacggacat ggcttgggaa aaatccttcg tggtacttac
     1561 gagcataagg ttatggggga cagtgttttt tcccatattc tttcttatac ttccggtgct
     1621 tgcgatgccc gtatggcagg agccatgatt ccggtcatga gtaattcagg aagcggtaat
     1681 caaggtatat ccgctacgtt gccggttttg atttatgccg aagaaaacgg gaaatcagaa
     1741 gaagaattga ttcgtgcctt gatgttgagc catttgacag taatctatat caagcagagt
     1801 ttgggacggt tatccgcctt atgcggttgt gtggttgctg ccactggttc cagttgcggt
     1861 ataacttggc taatgggggg tacttatgag caggtggcat atgctgtaca gaacatgatt
     1921 gccaatctta ccggaatgat ttgtgatggt gccaaaccta gttgtgcatt gaaagtgact
     1981 accggagttt caaccgcagt actttcagcc atcatggcca tggaaaaccg ttgtgtaact
     2041 tccgtagaag gtattattga tgaggatgtg gatcagagta tccgtaatct gacaaaaatc
     2101 ggttctaaag gaatgaatga aacggataaa ttggtattgg agataatgac aagtaaataa
     2161 ttaaaaaaat gaagaattaa aaatgaaaga attatcatgc agcatactta tattgcgtag
     2221 tttgattctt tcatttttaa ttcttcattt ttaattcttc tagtggcagc atccgcctcc
     2281 acattcatgg tcgccgcatc cgtcgccaca gtcaccacaa ccgcagctgc cgcaaccgcc
     2341 acccatcata cgggcgactt cggcaagttc ttcgtttgta gccaggcggc tttccactac
     2401 ttctccagtg aagttcaagt cacaacctgc gagcggatgg ttcatatcca ttacgacgat
     2461 atcttccttc acttctacca cacttccgtt gatgcgttga ccttcagaag tcatcaaggg
     2521 gataacggca ccttctacta cacgatcgct gtcgaattct ccttctatca tgaagatttc
     2581 tttggggagg tcaataacat ggtcgtcgtc atattcacca taagcttctg atgccggaat
     2641 ggtaaagtcg aatttatcgc ctatctgcaa gtcttttatc tgggcttcaa agggttcgag
     2701 tgtcattccc agacctgaga taaactgaaa aggatgctct acgggtgctt cttcttcgaa
     2761 atctttttct ccgttttcga ttgagtacag cttatatgct acggtgatgt acttgttttc
     2821 tactgtttcc attaattttc tatctttatt taattagtaa atactttttt ttgagtattt
     2881 gaagagacaa agatacgaat tatttgtttc gggatgtaga gagcctttgg taattttcag
     2941 attattaaat ggtttcaatg attggcaata catttacatt ggctgtctga atggttctat
     3001 ttagaactgt taagtgataa aataggattt tagggcgata ttttcttacg attattcata
     3061 tttatcttat ttttttcttc aatttgtttg gagattataa aaaagccctt acctttgcag
     3121 cacgtttgaa acaaaaaaga agaattaagt tatgaattta catacatcta ttaacctggc
     3181 agtcctgcat attattcgcg tcgtggtggt ggcatcaaga gcgtgagaaa ggttatgtat
     3241 gtattcgtac gttagaagat aatttattaa gcctttctca ctatagtggg agaggctttt
     3301 tcattaaaag gagatttgaa aatgaagcat cagttacgca gctcgttcag cacacaaggt
     3361 cgccgcatgg cgggagcccg tgcattgtgg acggcgaatg gtatgaagaa ggaacagatg
     3421 ggtaagccca ttatcgctat agtcaattca tttacacaat tcgtccccgg gcatgtacac
     3481 ctgcacgaaa taggccagtt tgtaaaggaa gagattgaaa aactggggtg ttttgctgcg
     3541 gagttcaata cgattgccat tgacgacggt atcgctatgg gacacgacgg tatgctttat
     3601 tccctgcctt caagagatat cattgccgat agtgtggagt atatggtaaa tgcccataag
     3661 gcagatgcta tggtttgcat cagtaactgt gacaagatta ctccggggat gctgatggcg
     3721 gctatgaggc tgaatatacc gactgtgttt gtttcaggcg gtccgatgga agccggggaa
     3781 tggaacggac agcatttgga tttgattgat gccatgatta aatctgctga tgaaagtgtg
     3841 ggcgataaag aggtggcaca gattgagcaa catgcctgcc ccacttgcgg atgctgctca
     3901 ggcatgttta ccgctaattc catgaattgc ttgaatgaag cgattggatt ggcactgccc
     3961 ggtaacggca cgattgtagc cactcacgaa aatcgcaaga aactatttga ggatgcagcc
     4021 aggttgattg tagagaatgc ctttagatat tatgaagaag gggatgagag tgtactcccg
     4081 cgcagtattg ctacccgcga ggcatttttg aatgccatga cgctggatat tgcgatgggc
     4141 ggttccacta atacggtact tcatttgttg gctgtggctc acgaagccgg agcggatttt
     4201 aagatggacg atattgacat gctctcccgc aagaccccct gcttatgcaa ggtggctccc
     4261 aatacccaaa agtatcatgt acaagacgtt aaccgtgccg gtggcatcat tgccatcatg
     4321 gatgagcttg ccaagggcgg attggtcgat acgaatgtcc gccgtgtgga tggaatgacg
     4381 ttggcagagg caatcgaccg gtatagtatt accagctcta atgtatgtaa agaggcaatc
     4441 aagaaatact ccagtgcggc agccggaaag ttcaatctgg tactcggctc acaaaatgcg
     4501 tcttataagg aactcgatac ggaccgtgcg accggttgta tccgtgattt ggaacatgca
     4561 tacagcaagg atggcggtct ggcggttttg aagggaaata tagctcagga cggttgcgtt
     4621 gtcaagactg ccggtgtaga cgagagtatc tggaaattta cggggccagc gaaagtcttc
     4681 gactcacaag atgcggcttg tgacggtatt ctgggtggaa aggtggtcag tggagacgtc
     4741 gtcgtcatca ctcacgaagg gccgaaaggt ggaccgggta tgcaagagat gctttatcct
     4801 acttcttata tcaaatcccg ccatctgggt aaggagtgtg cattgattac cgacgggcgt
     4861 ttcagtggtg gtacttccgg actaagtatc ggacatgttt ctcccgaagc ggctgccggt
     4921 ggtaatatcg gcaagattaa ggatggggac attatcgaaa ttgatatacc gaaccgttct
     4981 atcaatgtga agttgacgga tgaagagctt gcagcacgcc ttatgactcc ggtaacccgc
     5041 aaccgtgaag tctccaaagc attgaaagca tatgccagta tggtgagttc cgctgacaaa
     5101 ggggctgtga ggctgattga ttaaaagccc ccctttccga aagcgagggg aggagagaat
     5161 gaaacaaatt tttcaagcta ctattgagct tttaaatata atgaatagat aaagtatggc
     5221 tgataataat aaaaagagta acttttcctc cctctcccaa ggagagggtc ggggtgaggc
     5281 tctaataaca ggcgcagaag cattgatgcg ctctctggag catcagggag taaagactat
     5341 tttcggttat ccgggaggga gcatcatgcc ggtattcgat gccttatacg accaccggaa
     5401 ggaattgaac cacatcttgg ttcgccatga acaaggagca acccatgcgg tacaaggctt
     5461 tgcacgtgta tcaggcgagg ttggcgtttg tctggttacc agtggaccgg gtgctaccaa
     5521 tactatcacg ggcattgcag atgccatgat tgacagtacg cctatcgttg tcattgccgg
     5581 ccaggtaggg acgaacttct tgggtacgga tgcatttcag gaagtggact tggtaggcat
     5641 tactcagcct atcacgaaat ggagttacca gattcgtcgt gcagaagatg tggcctgggc
     5701 agtggcacgt gctttctatg tggcaaagag cggacgtccg ggaccggtcg tgctggattt
     5761 tgctaaaaac gcccaagtgg agaaaacaga atatgcgcct actaaggtgg actatgtccg
     5821 tagctatctt cccgttcccg aaatggagcc ggaggccata cggaaggctg ctgaattaat
     5881 aaatggtgcg gaacggcctt tggtgctggt aggacaaggc gtggagctgg gagaagccca
     5941 gcaagagctt cgtgctttca ttgagaaagc cggaatgcct gccggatgca ctttattggg
     6001 actttccgca ttacctacga accatccgtt gaacaaagga atgcttggta tgcacggtaa
     6061 cctggggccc aatatcaata ccaataaatg tgatgtcctt atcgccgtag gcatgcgctt
     6121 tgatgaccgt gtgacgggta aattggaaac atatgccaag caggcgaaga ttatccactt
     6181 tgatattgac cctgccgaaa tagataagaa tgtaaagacc gatgttgctg tcctgggaga
     6241 ttgcaaagag acactggctg ccgttaccca attgctggaa cccgccaacc atcaggaatg
     6301 gattgacagt ttccggcaat acgaggaagt ggaagaggaa aaggtaatcc gtccggaatt
     6361 acatccggca ggaaaagcgc taagcatggg tgaggtggtg cgtgctgtga gtgaggctac
     6421 ccataacgag gcgatattgg tgactgatgt cggccagaat cagatgatgt ccgcccgtta
     6481 tttcaaatac agcaaggaac gtagcattgt tacttccggt ggcctgggta ctatgggctt
     6541 cggccttccg gcagctatcg gtgccacttt tggacgtccg gaccgcacgg tatgcgtatt
     6601 catgggagac ggcggcttgc agatgaacct gcaggaactg ggtaccatca tggaacaaaa
     6661 ggctccggtg aagatgattc tgttgaacaa taacttcctg ggcaatgttc gtcaatggca
     6721 ggcgatgttc ttcaatcgtc gttattcgtt tactccgatg atgaatccgg attatatgaa
     6781 gattgcttcg gcatatgata ttcctgcacg cagggtaatg acccgcgagg agctggcaaa
     6841 agcgattgac gagatgatag cgactgacgg accgttcctg ctcgaagctt gtgtggagga
     6901 agaaggaaat gtaatgccga tgacacctcc gggcggttcg gtcaatcaga tgttgttgga
     6961 atgctgaagt catgcgaaat taaagaactt actctatcta tggataaaaa actatataca
     7021 atcattgttc attcggaaaa ctttgccggt ttgctgaatc aggtgacggc tgtgtttacc
     7081 cgccggcaga taaacatcga gagtttgaat gtatcggcct cctccatcaa gggggtacat
     7141 aaatatacca ttaccgcttg gacggacaag gataccattg aaaaggtgac caagcagatt
     7201 accaagaaaa tagatgtgct gcaagcccat tatttcacgg atgatgaaat ctatcagcac
     7261 gagattgccc tttataaaat aacgacccct acgctggaag aaaaaccgga ggtgtccaaa
     7321 gtaatccgta agtacaatgc ccgtattgtg gaggtgaatg ctgtatttgc cattgttgag
     7381 aagaatggca tgagtgagga aataaccaat ctttatgagg agttgcgcca gttggattgc
     7441 gtacttcagt tcgtccgttc gggtcgcgta gccattacga ccagctgctt tgagcgtgtc
     7501 aatgaatatc tggcggaccg tgaagcaaaa tatcgtcaaa gtaaacacca ggaatcatga
     7561 tgagcgagaa caataagata ggtacctaca agtttgttgc cgaaccgttt catgtcgact
     7621 ttaccggacg gctgacaatg ggagtattgg gcaaccattt gttgaattgt gcgggtttcc
     7681 atgccagcga ccgcggtttt ggcatcgcga ctctaaacga ggacaattat acttgggtat
     7741 tgtcccgtct ggctgtcgaa ctggatgaaa tgccttatca gtacgaagat ttctccattc
     7801 agacttgggt ggagaatgtc tatcgccttt ttacagaccg taatttcgct atcatcgata
     7861 aggagggtaa gaagattggg tatgcacgtt ccgtttgggc gatgattagc atgaataccc
     7921 gtaagccggc agatttgctg gctcttcata gtggcagcat tgtagattat gtttgcgatg
     7981 agccttgccc gatagaaaaa ccttcgcgga taaaggtggc ctcaaaggaa ccggttgctg
     8041 ctttggtagc caaatacagt gatattgaca ttaacgggca tgtgaacagc atccgttaca
     8101 tcgagcatat ccttgatttg ttcccgatag agatgtataa ggagaagcgc atccgtcgtt
     8161 ttgaaatggc atatatagcc gaaagctatt atggggatga gttgactttg ttcatggatg
     8221 atgccggtga gggcgtttac gatgtggagg tgaaaaagaa tggcagcgaa gtggtctgtc
     8281 gctctaaagt gatatttaca gagaaataaa taaatttatc aacgttggcg taagccacaa
     8341 ataaaaatta aaacaaaaaa tggcacaatt gaattttggc ggtgttattg agaatgtaat
     8401 gacccgcgaa gaatttcctt tggaaaaagc acgtgagatt ttgaaagatg aaacaattgc
     8461 agtaatcggt tatggcgtac aaggcccggg ccaggcttgc aacttgcgtg ataacggttt
     8521 caatgtgatt gtaggacaac gtccgggtaa gacatacgaa aaggctgtgg ctgacggatg
     8581 ggtaccgggt gagactttgt tcggcatcga agaggcttgt cagaaaggta ctatcgtcat
     8641 gtgtctgttg tctgacgcag ctgtaatgtc tgtatggccg actatcaaac cttatttgac
     8701 tcccggaaag gctctttact tctctcatgg ttttgctatt acctggaacg accgtaccgg
     8761 cgtggttcct cctaaagata ttgatgttat tatggttgct cccaaaggtt ccggtacttc
     8821 acttcgtacc atgttcctcg aagggcgtgg cttgaactca tcatatgccg tctatcagga
     8881 tgctacgggt aaggcttttg acaagacgat tgcactgggt atcggtatcg gttcgggata
     8941 tttgttcgag acaactttca tccgcgaagc cacttccgac ttgaccggtg aacgcggttc
     9001 attgatgggt gctatccagg gattgctgtt ggctcagtat gaagtattgc gcgaaaacgg
     9061 tcacactcct tctgaagcat tcaatgaaac tgtggaagag ttgactcaat ctttgatgcc
     9121 attgtttgcc aagaatggta tggactggat gtatgccaac tgttctacta cggcacagcg
     9181 tggtgcgctg gattggatga ccccgttcca tgatgccatc aagccggttg tacagaaatt
     9241 gtatgcaagc gtgaagtcgg gtaacgaagc tcagatttct atcgacagca actccaaacc
     9301 cgattatcgt gagaagctga atgcagaatt gaaagccttg cgtgaaagcg aaatgtggca
     9361 gacagctgtt acagttcgta aacttcgtcc ggaaaacaat taatcagctt tatataaata
     9421 ggtgaaatac cctcttcggt gttaccggag ggggtatttc tttattattg attccctata
     9481 ttttgaataa actccaatag cttccggtaa aaaccgtgat gtttcagcgt ctctgcctct
     9541 cccaatatca ccagcttcat acgtgcccgg gtgatggcta cattcattct ccttaaatca
     9601 ttcaggaatc ctatctgccc ttcttcgttg gcgcggacaa ggctgatgaa gataacatcg
     9661 cgctcttgcc cttggaagcc atccaccgta tttacagtga acaagctgcg ataaggcttg
     9721 agtgaagcgt ctgcctttat cttgttgcgg agatattgca cttgtgcctt gtaaggggag
     9781 atgatgccga agtctatttt ttcttccaga atgcggctgc caccgatacg gttgatgtag
     9841 attttcagtt ctgataggag caggtccgct tccgctttat tgatgcgtcc gaaagtctct
     9901 cccacaaatt cttctttgaa atccatttcg gaggtgtcaa tccagtggat aggggtatcc
     9961 cagtccagga tgccccggta acgcacttcg ggagcggctt ccaactcgcc attataaaac
    10021 cattgggaag gaaatttcat gatttcctcg tgcatgcggt attgcacttt cagcaaagag
    10081 acaacggcag gtttgttgga caccactttc tccatcaatg ttcgttccag acctccacgg
    10141 gcggcttcgt ggcattttat ggtgggcgga agttggcagt ggtcacccgc caataccacg
    10201 cggtctgctt ttcggatagc tatccagcag gcagcctcta aggcctgggc tgcttcatca
    10261 atgaaaaggg tgccgaaacg gcgtccgttc agcagccggt gattgctgct taccagcgtg
    10321 gaggctatga cgtgtgcccc atcaaaaagc tctgaattga tttgtatttc caatgcggtg
    10381 gcgcggtcgc gcaggcggct catacggctg cgtactcctt cgcgttcgtc atagctgcca
    10441 cggcgggcac ggctgcccag ttcacggaga tttttccgga tgctccacag ttccggataa
    10501 agcggatggt tctcgaaacg acgctcgtag gtaaaggaaa gcatcttgtc gttgacacgg
    10561 gtcggattgc cgatacgcag gacattgacg ccacggtcca caagtttttc cgaaatccag
    10621 tcgacggcag tattgctttg ggcacatact agtacctgcg gttcccgatg cagggtttcg
    10681 tagatggctt ccactaaggt ggtcgttttt ccggttcccg gaggaccatg tacaatggcc
    10741 acgtcgcggg cacacagcac tttgtttaca gctgtctcct gcgtggagtt cagccaggga
    10801 aaccgtacgg ggtagagctc tcggaaaccg gctttcgagg ttcccagcaa tatgtcccgc
    10861 aattcggcca ggcggttgcc tttggagcgt aacgtatctt ccaaggcttc gaacatggtc
    10921 cgataggatg tttcgtcgaa ataaagttgc acgccgaggt tgtccgtttc ctgcacttcc
    10981 ataacggcac cggctccggg cattatcgct accatccgtg tctcgtcggc atagcttacg
    11041 gtagcggtga agttcatata ggttattttt ccatcggcag actggcggaa aaaacatacg
    11101 ggacggccga actcaaaatt atgttctata tcggtatttt ctgtgtgtgt aatttctatt
    11161 actaattgat tcagtgaatt atagtaactt cgtcccggag tggcaggata ccagcaaagt
    11221 ccccgtttca ctttccgggc aactcccatg ttttcggttt ggcgtttgaa ttcctctttt
    11281 tcgtattcgt attccatgcg cagcaaaagt tgttgctgct ggaggtgaat aataggacta
    11341 tttgaatctt gttccttcat ggttgcaaag gtaatcattc ttcgcttccg acagaaaaaa
    11401 tgctttattt tgttaaacta ttcagccttt ttatttgttt atgatattaa tttgtaatct
    11461 ttacaataat gaaaaactaa aaaatagtgg ttatggtata tgatttaacg atgctcaaaa
    11521 cgttttatgc cgcttattcg gagaagatag aacgcgtacg gaacgtactg cggcgtccga
    11581 tgactttagc agagaaaatt ttgt
//
