LOCUS       c00044_gnlPro..        14444 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EGDDIHPI_44.
ACCESSION   c00044_gnlPro..
VERSION     c00044_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 14:00:27
            Original ID  :: gnl|Prokka|EGDDIHPI_44
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 27139
            Orig. end    :: 41583
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14444
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[37139:40697](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13558
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..14444
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14444
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             1222..4869
                     /locus_tag="ctg44_21"
                     /transl_table=11
                     /translation="MGIFDKKRIIVVCFFVFFCQMIFSQSQKFRGYPQKDADILSGFSC
                     PPKGYGNVPFYWWNGDSLNRERMKEQLEILSESATDGFAVSYIHLDPKVDVENMKDGYG
                     LFGKTESGRPKIFSEDWWNTWSWFAKECASKNIGLGLDDYTVGWIGNGYYSDELQEMAK
                     FRGYQGELNIQSVTVKGGTTFTYDIPDKFLTAVVWPGKTDLTKYISGDKLLWEVPCDNS
                     YKVYIISTKENHLLHPDIGKEYVRVYFDRFERRMSDAVPDGMNYFFQDELSYPIKMGSW
                     AEDFRDEFEKRKGYDITLYLPALKEFIGDITPKIRLDYCDVLMDLAEERYFRPIYDWHV
                     SRGLIYGSDNLRRGKDPLAYVDYFRANSWYTAPGNDAPSTGSSFLQTKVSSSITHLYER
                     QRTWLEAFHSMGWGSSASWLTKQMDHHFMAGGNLVCMHGLYYSTHGGWWEWAPPCFHFR
                     MPYWPHMKRWLEYTERLSYLMSQGTHVCDIALMYPTESLQAYPEANTKITFDQAMKLSN
                     AGLDYDFMDYRSLQKAKVADGCLHVAGEKYKILILADMKALHYASMEKVLEFYRAGGIV
                     IATGELPKASTRIGESDPVMDAMVREIFGLTAGEVVRGKTTDKRVNTSGGTGIYIAGDD
                     LVEQIWSQITPDFKPVGGAGKALHRCIGERDVYMVMDVPKGTECFFRATGKVELWNAFD
                     GTIIDYPVVRQTEEGTWLLLEKESDNSYLFVFSPGIPVFLPEYRKESIQIYHTAITGVW
                     ETELLPTMDNKWGDYRFPASDMIGAEARSFKHCAAALSPDNWMNPYFDDSGWKESIYGY
                     GEQFVSYFKSAGESMSNISDVLAESRKPGKILEFSWQFGVFDNPGSQGWHGLKGKVSDG
                     FFILDQGGHQIYRSMVYAPAKDNYRVEVCGIKPDFLLVDGKAVNENLLLDQGWHQVVVA
                     YIGTPKMEFKFQKGAYRDFRERSAVVFFPASSLTPEKPSTYAKVISTRWALGDHLLYDP
                     YGGDNLMWNYRFRSAPGTEELEITVVGQDLKIWHNGKEITGKNVQLLSTDRSGICKYRV
                     IIPTPRKDAGLIAFSVRRKPGYQGTAVICEPIKIKTGKGILEAGNWSETGALKHYSGGM
                     YYRKEVVIPSIKSNNKVILDLGEVNASCEVKVNGQDVGIVMGSLYTVDISKQVKSGKNH
                     IEVLVYSTLSNHYQIIPTPYRGDGVAGLLGPVSLTVWETPSLKTKVPVR"
     CDS             5418..6326
                     /locus_tag="ctg44_22"
                     /transl_table=11
                     /translation="MMNRRLFLKKACGGVLVLAASPSFVSCGGQRPVRFGVVTDLHYSR
                     REPYGTRYFPQTMDKLKEAMEVFNSSNLDFVIEMGDLKDQDNVSQREQTITYLDEIENV
                     FQSFRGPVYHVLGNHDMDSISKDDFLQHTSNQGDADKKAYYSFAFDNIKFIVLDANYNL
                     DGTPYDKGNFDWTKAYIPKDQIDWLKKELKGNNKPVIIFIHQLLDRFSDISKSLCVSNA
                     DEIVPLLEENGNVLAVFQGHHHAGHYSFRNNIHYWTMKGMIEGNLPDNNSFAVVEIDTQ
                     NNIHIDGFYNCEDKDLNRFTV"
     CDS             complement(6549..7499)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MTHFR"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg44_23"
                     /sec_met_domain="MTHFR (E-value: 5.4e-64, bitscore: 207.1,
                     seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVIDLINGSKTTAFSFEILPPLKGNSIQKVYNVIDKLKEFDPKY
                     INITSHHSEYIYKTLPDGSFQKVNIRKRPGSVAIASAIQNKYGIPAVPHIICKGFTKDE
                     TEYALIDLNFLGVYDLLLLRGDVKTLEAGQNTDLYHEHATDLQEQVNNFNKGIAVDGST
                     FEANETPFSYGMACYPEKHEEAPNMESDIFYLKEKVKNGADYLVTQMFFDNEKYYSFVE
                     RCRAEGIDVPIIPGIKPVVFKNQLTVLPKIFRSDIPEPFAAELRKCKNDDEVKAVGVEW
                     CIQQCKDLIAHGVPSLHFYTMMATDSVYKVAKEVY"
     CDS             7583..8602
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg44_24"
                     /sec_met_domain="Aminotran_4 (E-value: 2.5e-32, bitscore:
                     103.4, seeds: 70, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENMNWSDLAFGYMKTDYNVRCYYRDGKWGELEVSSSEIINIHMA
                     ATCLHYGQESFEGLKAFKGKDGRIRVFRMDENGKRMQASSRGIKMAELPVEMFEEAVRK
                     VVKLNERFVPPYESGAALYIRPLMIGLGAQVGVKPAPEYMFMVFVTPVGPYFKGGFKPS
                     KVCIMREYDRAAPYGTGTIKVGGNYAASLVAGEIAHEKGYAAVLYLDPKEKKYLDECGP
                     ANFFGIRGNSYITPQSHSILPSITNKSLQQLAEDMGLTVERRPVPFEEIATFDEAAECG
                     TAAVIAPISQIDDLDENKSYVIAKDGKPGPVCEKLYNKLRGIQYGDEPDTYGWVTVIE"
     CDS             9335..9775
                     /locus_tag="ctg44_25"
                     /transl_table=11
                     /translation="LFGSQTDGLFSGLFASWFLSVLPGETQFLREPVEDNEYDAGGRCL
                     VHQANRAKLSAQTPQTVVSAGYQRTVYAECQSVEQRNRNVTGYSDELYKISDRCPFNEY
                     VISGRRIVSEKTIYRVYVQFESDVPHPSDGGKCAGCARIFFL"
     CDS             9732..9968
                     /locus_tag="ctg44_26"
                     /transl_table=11
                     /translation="MEVNVQAVRESFFYNQLLKDNTLNEGMKNAHFLVNGKYNFRIEES
                     MKVKNNPDLYYAVDKVEVGEENMIPLWLFGFLY"
     CDS             10001..13558
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_27"
                     /sec_met_domain="PFOR_II (E-value: 1.9e-19, bitscore: 60.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 8.7e-83, bitscore: 268.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 7.3e-32, bitscore: 101.7,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.5e-13, bitscore:
                     39.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 9.9e-13, bitscore: 39.8,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.6e-07, bitscore: 21.9,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.4e-05, bitscore: 14.9,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.9e-24, bitscore: 76.2,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFLTCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVMVQEMQSEGGAAGAVHGSLQAGALTSTYTASQGLLLMIPNMYKIAG
                     ELLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFVNFFDGFRTSHEIQKIEALENDDLAPLIDQKALAEFRARALNPEKPEARGMAE
                     NPDHFFQHRESSNKYYEAVPAIVEEYMNEISKLTGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLTAQGEKVGLVSVHLYRPFSAKHFLAAVPKTAKRIAVLDRTKEPGATGE
                     PLYLDVKDCFYGQADAPVIVGGRYGLGSKDTTPAQILAVYENLALPMPKNQFTLGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKYCQAYFSYDS
                     KKSGGFTCSHLRFGDHPIRSTYLVNTPNFVACHVQAYLRMYDVTRGLRENGTFLLNTVW
                     NGEELAKHLPNKVKRYFAQKNITVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DLAIEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYTQLTVDPDWANLPDDEVVANNDP
                     AFINEVVRPINAQDGDLLKVSAFEGIEDGTWHQGTAKYEKRGVAAFVPVWEPDNCIQCN
                     KCAYVCPHASIRPFVLDAAEQAAAPFNNSLKATGKQFEGMQFRIQVDVLDCLGCGNCAD
                     VCPGNPKKGGKALKMAALETQLDEAPNWDFCAEKVTTKQHLVDIKANVKNSQFATPLFE
                     FSGACSGCGETPYVKLVTQLFGDREMVANATGCSSIYSGSVPSTPYTTNDKGQGPAWAN
                     SLFEDFCEFGLGMELANEKMRARLTNAMNEIIAADNAPAEAKEVLKAWVENQNDADKTK
                     ELAPQVLAIAEEGITHGCPLSAQIKELSHFLVKRSQWIIGGDGASYDIGYGGLDHVIAS
                     GKNVNILVLDTEVYSNTGGQSSKATPVGAIAKFAASGKRIRKKDLGLMATTYGYVYVAQ
                     IAMGADQAQTLKAIREAEAYDGPSLIIAYAPCINHGLKKGMGKSQQEEADAVACGYWHL
                     WRYNPALEEEGKNPFTLDSKEPDWSKFQDFLKGEVRFASLTKQFPAEAAQLFQAAEDNA
                     KWRLNNYKRLAKQQWGVEE"
     CDS             13668..14324
                     /locus_tag="ctg44_28"
                     /transl_table=11
                     /translation="MAKNKSKQNQFQLLSPEKYIRLKARNLPIEVCYVSDDWKDERGAV
                     AEVIVVRRHAGGNYTFGVYVVDTLCLGVKHSVYRFNVPPDEYDDFVERTATDCGIKISY
                     NEAHNFIYGAIAFAEEFGIKPDKSFALTQYILEEDTEEIPLIEYKYGRGGRPHLVAETS
                     LEASKYIPILEESTGGDFGLEILEDRDVFDDDEFDDEFDDDEFDDEYDEEDNKTM"
ORIGIN
        1 ttcgggcaac attgacacgt gctaagaaaa atggcttaga agcttttatt acatacagga
       61 tgaatgacct acattttgca gatactttgg gaaattgtcc tgtatggtat agtgattttt
      121 ggatgaacca tccgcaatat tggactaacg atccttcaca aggatggaat agtgccggtg
      181 cactcgactt ttcgcataag gaagtgcggg aacataaact ggctatcatc gccgagcaac
      241 tggaaaaata tgagatgata gacggttttg atctggattt tatgcgtttt attgtaaatt
      301 tcaaaacgga ggaatatgca caaaatgtgg aagttatgac acaattcgta agggatatac
      361 gaagcaaagt agatcaaatt tcagtaaagc gtggaagaaa aatattatta tcggcacgtg
      421 tcccgcctac tgttcgggat tgtttggata aagctttgga cgtaaaaaca tggatacggg
      481 aaggactggt tgatttttta agtataggag tgcattggcg cggaaatcca gctatgccgg
      541 tggctcgttt taaagaggat ttaaatggtt tgaaaattcc cgtttatgcc agtattgatg
      601 atggtggtta taaggcccgt gaattatggt cacatggtat gcataggggg atggcgtcac
      661 atgctttggc tcagggagcc gatgggttat atttgtttaa tttctatttt ggtcaatatg
      721 ctaatgccgg aaaaaaatat accttggagc ctggtagttt ggtatgcagg gcgatgattc
      781 ctgaattgtt gcaggaactc ggctcgttga atacattaaa aaacaggaat aaaatatatg
      841 ctttatcaga tggcataagg gaataccgtg ttgatccggg ttctcctttg ccattgaatg
      901 tagtaggaaa tgctgtagct ccatttttta taggggatga tgtaaaaaaa catccgccat
      961 tggaggctat tcttttcatc cgtaataatg agaatacgga ttttaaggta tttgtcaatg
     1021 atatcctttt agtagaacag cattcggaat atgttgcttt atacgataaa gcacgcggac
     1081 tgaaaggtaa agagtgtgaa tatgccttta ttgttccagt aaatgaaatg attaaaggat
     1141 ataataacat tcgttttgaa ggtgagggtt ttgttgtaaa aaggattgaa ttggcactaa
     1201 aatatgggga ggtggaaacg catgggtatt tttgataaga aaaggataat agtagtttgt
     1261 ttctttgttt ttttctgtca gatgattttt tcccaatctc agaagtttag aggatatccg
     1321 caaaaggatg cagatattct ttccggattt tcctgccctc cgaaaggtta tggaaatgtt
     1381 cccttttatt ggtggaatgg tgatagtctg aacagagaac ggatgaaaga acaacttgag
     1441 attttgtcag agtcggcaac ggatggtttt gctgtgagtt atattcattt ggatcctaag
     1501 gtagatgttg aaaatatgaa agacgggtat ggcttgtttg gaaaaacaga atcaggaagg
     1561 ccaaaaatct tttcagaaga ctggtggaat acctggagtt ggtttgcaaa agaatgtgca
     1621 tcgaaaaata tcggattagg attggatgat tatacggttg gttggatcgg taatgggtat
     1681 tattctgatg agttacagga aatggcaaaa tttcgtggtt atcaggggga actgaatatt
     1741 caatcggtaa ctgtaaaggg aggaacaact tttacttatg atattcctga taaattcttg
     1801 acagcagtag tatggccggg aaagacagat ttaacaaaat atatctccgg agacaaactt
     1861 ttatgggaag taccgtgtga taacagttat aaagtttata tcatatcgac aaaagaaaat
     1921 caccttctgc atccagatat aggtaaagag tatgttcgtg tatatttcga tcgtttcgaa
     1981 agacgtatga gtgacgctgt tcctgacgga atgaattatt tttttcagga cgaattgtca
     2041 tatcctatta aaatgggatc atgggcagaa gattttcggg atgaatttga aaaaaggaaa
     2101 gggtatgata taactttata tctgccggca ttgaaagagt ttataggtga tatcactcct
     2161 aaaatacgtt tggattattg tgatgtcttg atggatttgg cggaagaacg ttattttcgt
     2221 cctatttatg attggcatgt ttcgcgtgga ttgatctatg gtagtgataa tctgcgccgt
     2281 ggcaaggatc ctttagcata tgtggattat tttagggcaa attcctggta tacagctccc
     2341 ggtaatgatg ctccatcaac aggctccagt tttctgcaaa ctaaggtgtc gagttctatt
     2401 actcatctgt atgaacgtca acggacatgg ttggaagctt ttcatagcat gggatgggga
     2461 agttctgctt catggttgac taagcagatg gatcaccatt ttatggctgg tgggaatttg
     2521 gtatgtatgc atggattata ttattctacc catggaggtt ggtgggaatg ggcacctcct
     2581 tgtttccatt ttagaatgcc ctattggccg catatgaaaa gatggcttga atacaccgaa
     2641 aggctgagtt atttgatgag tcagggaaca catgtttgtg acatagcact gatgtatccg
     2701 acagaatctt tgcaagcata tcctgaagct aatactaaaa ttactttcga tcaggctatg
     2761 aagttgagta atgccggttt ggattatgac tttatggatt atcggtcatt acagaaggca
     2821 aaagtggcag atggctgttt acatgtggca ggcgagaaat ataaaatact catacttgct
     2881 gatatgaaag cattacatta tgcatctatg gaaaaagtgt tggaatttta ccgggcaggt
     2941 gggattgtca tagcaacagg ggagttgcca aaggctagta cgcgcatcgg ggaaagcgat
     3001 cctgttatgg atgcgatggt tcgtgaaata tttggcttga ctgcaggtga agttgttcgg
     3061 ggcaaaacaa cggacaagcg ggttaataca tctggtggaa ctggaatata tatagctggc
     3121 gatgatctgg tggaacagat ctggtcacag attaccccgg acttcaaacc tgttggtgga
     3181 gccggaaagg ctttgcatcg gtgtatcggg gaaagggatg tatatatggt catggatgtt
     3241 cccaaaggta cggaatgttt tttcagagct actggcaaag tggaattgtg gaatgcattt
     3301 gatgggacaa ttatagatta tcctgttgtc cgtcagacag aagagggaac atggcttttg
     3361 cttgaaaaag aatcggacaa ctcgtatttg ttcgtttttt caccgggaat accggtgttt
     3421 ttaccggaat atcggaaaga atcgatacag atttaccata ctgctattac tggggtatgg
     3481 gaaacagaat tattgccaac aatggataat aaatgggggg attatcgttt tcccgcatcg
     3541 gatatgatag gtgctgaggc tcgttcgttc aagcattgtg cggctgcatt atcacctgat
     3601 aattggatga atccttattt tgatgattct ggttggaaag aaagtatata tggttatggg
     3661 gaacaatttg taagttattt caaatcggca ggagagtcta tgagcaatat atctgatgtt
     3721 ttggctgaaa gtaggaagcc gggaaaaata ttggaatttt catggcagtt cggagtcttt
     3781 gacaaccccg gttcacaggg atggcatgga ctaaaaggaa aagtaagcga cggtttcttt
     3841 atcttggatc aggggggcca ccaaatatac cgtagtatgg tttatgcacc cgcaaaggat
     3901 aattaccgag tggaagtgtg tggtattaaa ccggattttc tattggttga tgggaaagct
     3961 gttaatgaaa atcttttact agatcaaggt tggcatcagg tggttgtcgc ctatatcggt
     4021 acccccaaaa tggaatttaa attccagaaa ggtgcttata gggattttcg agaaagaagt
     4081 gctgttgtgt tcttcccagc atcttctctt acaccagaga aaccgtctac ttatgccaaa
     4141 gtcatttcta cgcgttgggc tttgggagat catcttttgt atgatcctta tggaggtgat
     4201 aaccttatgt ggaattaccg ttttcgttct gcgccaggta cggaggaatt agagataact
     4261 gtagtagggc aggacctgaa aatatggcac aacgggaagg aaataacagg aaaaaatgtt
     4321 cagcttcttt caacggatcg ctcgggtata tgcaagtacc gggttattat tcccactcct
     4381 cggaaggatg caggattaat tgctttctcg gttaggcgga aacctggtta ccaaggaaca
     4441 gctgtcattt gcgaaccgat aaagataaag actggcaaag gtatactgga agctggtaac
     4501 tggtcggaaa caggggctct taagcattat tcggggggga tgtattatag gaaagaggtt
     4561 gttataccct caataaaatc gaataataag gtaattcttg atttgggcga agttaatgcg
     4621 tcgtgtgagg taaaagtcaa tggacaagac gtaggtatag ttatgggttc tctgtacacg
     4681 gttgatatca gcaaacaggt caaatcaggg aagaaccata tagaagttct ggtatacagc
     4741 acattgtcta atcattatca aattatccct actccctata gaggtgacgg tgtggctggt
     4801 ttgttaggtc cggtgtcgct gacggtttgg gaaactccat cgcttaagac aaaagtccct
     4861 gtaagataat gtttccagcg aagacacatt ataagaagca attaaaaagg cctttttata
     4921 aatccatgta aattataccg aatgaatttt gtcaggatgt tcattcggta taatttgttt
     4981 ttaagttctt ttgtattgaa aatcagtgag ctggttgtat cttatcaaag atgcatttta
     5041 ctatataaat tagtagcaga aaaggatata ctgccagatc catagtaatg aatagtatgt
     5101 atttcatttc ttttttcttt taaattccac ctgtaagaca gaaatatttc aaaaacccct
     5161 atcggcctga cagatttttt tgtatttgta tgaaaagaag atgagcaaag gctctaaaaa
     5221 gatgcatctg ggtttgaaat tggggtaatt taacaaataa gcttttttcg ggagattgaa
     5281 aatttgttct caactcatcc taaatccggg atggtagata tattgacttt ttattattaa
     5341 tattgtaagc caatgctgat agcctgctac atccggcagg ttaccggcat gactctataa
     5401 cctatgaaat ttttaatatg atgaacagac gcttattttt aaaaaaggca tgcggagggg
     5461 tgttggtcct ggcagcttct ccttcatttg tatcctgtgg tggacaacgg cctgtccggt
     5521 ttggggttgt taccgatctg cattattcgc ggcgggaacc ttatgggacc cgttatttcc
     5581 ctcagacaat ggataagttg aaagaggcca tggaggtctt caactcttcc aatctggatt
     5641 ttgtgatcga aatgggcgat ctgaaggatc aggataacgt ctctcagcgg gaacagacaa
     5701 ttacttatct ggatgaaata gaaaacgtct ttcaatcgtt ccggggaccg gtttatcatg
     5761 tcctgggaaa tcatgatatg gatagcatct ccaaagacga tttcctgcaa catacctcca
     5821 atcaggggga tgccgacaag aaagcttatt attcatttgc ctttgataat ataaaattca
     5881 tagtcctgga tgcgaattac aatttggacg gtacaccgta tgataaaggt aattttgact
     5941 ggacaaaggc atatattcct aaagaccaga tagactggtt gaaaaaagaa ttgaaaggaa
     6001 ataacaaacc ggtcatcatt tttatccatc agttgttaga ccgcttctcc gatatcagta
     6061 aatcgctttg tgtaagtaat gcggacgaaa tagttcctct gttggaagaa aatgggaatg
     6121 tgctagctgt attccaggga catcatcatg cgggacatta cagtttccgt aataatatcc
     6181 actactggac aatgaaaggg atgatagaag gaaaccttcc cgataacaac agttttgctg
     6241 ttgtggagat cgatacgcag aataatattc atatcgatgg tttctataat tgtgaagata
     6301 aggatttgaa tcgcttcacg gtgtaaagtt attcagttga tctgcgtaaa gcaatctaat
     6361 gttttttcag acagaggtag gtctaaataa atttagaggt aggtgtaaat tgaattagag
     6421 gtacgtctaa attcatttac acctacctct aatttataag acatagtaat gttctccgga
     6481 tttagtcagt attacgcttt ttatccaatc cgttgtctcc tggcaatcga ttagttccat
     6541 caacgatttt aatatacttc ttttgccact ttataaacac tatccgtagc catcattgta
     6601 taaaaatgca ggctggggac accgtgggcg atcaggtctt tgcattgctg gatgcaccat
     6661 tccacgccaa ccgcttttac ttcatcatca tttttgcatt tgcgcaattc ggctgcaaac
     6721 ggttcgggaa tgtctgagcg gaatatttta ggtaatacgg tcagctggtt tttaaagaca
     6781 accggcttga tgcctgggat gatcgggaca tcgatacctt cggcacggca gcgttccaca
     6841 aatgaataat atttttcatt atcgaaaaac atctgggtaa ccagatagtc ggcaccgttt
     6901 tttactttct ctttcagata aaaaatatcc gattccatat tcggtgcttc ctcatgtttt
     6961 tccggatagc aagccatacc gtatgagaac ggtgtttcgt ttgcttcgaa tgtggaaccg
     7021 tctacggcaa tacctttatt gaaattgttt acctgttcct gaaggtcagt cgcatgttcg
     7081 tgatataaat ccgtattttg tccggcttcc agtgttttta catcaccacg caacagcagc
     7141 aggtcgtaaa ctcccaggaa attaagatcg atcaacgcat attccgtttc atcttttgta
     7201 aatcccttac atataatatg tggaactgcc ggaataccat atttgttctg gatggcagaa
     7261 gcaatggcaa ccgaacccgg gcgcttgcgg atgttcactt tctggaagct gccgtcgggc
     7321 aaggtcttat agatatattc gctatggtga gaagttatat taatgtattt agggtcgaat
     7381 tctttcagtt tatcaatcac attatatacc ttctgtatgc tgttcccttt cagaggaggt
     7441 agaatttcaa atgaaaaagc agtcgtttta ctgccgttga tcagatcaat aactttcata
     7501 ttttaattat ttttgctgca aaagtaacaa ttatcatccg aaatagctta cttttgcgct
     7561 cataatctaa ttacgacaag atatggaaaa tatgaattgg tctgatctgg cattcggtta
     7621 tatgaagaca gactacaatg tacggtgtta ctatcgtgat ggtaagtggg gtgaattgga
     7681 agttagctct tctgaaatta tcaatattca catggcagct acttgcctcc attacggaca
     7741 ggagtcgttt gaaggtttga aagcattcaa gggaaaagac ggtagaatcc gtgtgttccg
     7801 tatggatgaa aacggcaaac gtatgcaagc ttccagccgg ggcatcaaga tggctgaact
     7861 tcctgtggaa atgtttgaag aagcagtccg taaagttgtg aagttgaacg agcgttttgt
     7921 tcctccctat gagagtggag cagcattata tatccgcccg ctgatgatcg gtttgggtgc
     7981 gcaggtgggc gtaaaaccgg ctcccgaata tatgtttatg gtattcgtaa ccccggtagg
     8041 accttatttc aaaggtggtt tcaaaccgtc aaaggtttgt atcatgcgtg aatacgaccg
     8101 tgctgcgcct tatgggactg ggacgatcaa agtcggtggt aattatgcag ccagcctggt
     8161 agccggagaa atagcgcatg aaaaggggta tgccgccgta ttgtatctgg acccgaaaga
     8221 aaagaaatat ctggacgaat gcggtcctgc caacttcttc ggtattcgtg gaaacagtta
     8281 catcactccg cagtctcatt ctattctgcc gtctatcact aacaagagtt tgcagcagct
     8341 ggctgaagat atgggactga cggttgaacg tcgtcctgtt ccttttgaag aaatagctac
     8401 attcgatgaa gcagcagaat gcggaacagc tgccgttatc gccccgattt cacagattga
     8461 tgatttggat gaaaataaat catacgtgat agccaaggac ggtaaacccg gacctgtttg
     8521 cgaaaaacta tataacaaac tgcgtggcat ccaatacggt gacgaacctg atacatacgg
     8581 ttgggttacg gtaattgaat aatcagataa aagatgttga cagttaatgt ttttagataa
     8641 accggaagca ttaactgcca actctaaatt ctcaaacgtc aatacgcttt gccaactttg
     8701 gattgccaac tgaaaataaa attgctatct cggtattgca aagttgagga tattttctat
     8761 ctttgcggtc tatatagtaa gacagtcagg tggaagcatt ctttaaaaca cataaatacc
     8821 ttgtagaaca tttgcatgca ccggtacgcc gggggctgat ggatgagatt gattggaatg
     8881 accggttgat cgggatcaaa ggctctcgtg gagtagggaa aactactttt ttgctggatt
     8941 atgcccgcga acattttggt gctgataata aagagtgcct gtatataaat ctgaatcact
     9001 tttattttac ggaacgtacg ctggtcgact ttgcttctga gttcagggca aaaggaggga
     9061 aggtgttgtt gattgaccag gttttcaaat attccggatg gtcgaaagag ttacgttatt
     9121 gttatgataa ttttgaagat ctgaagatta tcttttccgg ttcgtcagtg atgaggttga
     9181 aagaggaaaa tccggatctc tcaggtaaag ttgtttcata taatttgcgt ggtttttctt
     9241 tccgagagtt tttgaatctg atgtcgggaa acagttttcc ggcttatacg tttgaagaaa
     9301 taatcgggaa ccatcaggag attgcgaaga atatttgttc ggtagccaaa ccgatggctt
     9361 attttcagga ttatttgcat catggttttt atccgttctt cctggagaaa cgcaatttct
     9421 cagagaacct gttgaagaca atgaatatga tgctggaggt agatgtcttg tacatcaagc
     9481 aaatcgagca aagttatctg cccaaactcc gcaaactgtt gtatctgctg gctatcagcg
     9541 caccgtgtac gccgaatgtc agtcagttga gcaaagaaat agaaacgtca cgggctacag
     9601 tgatgaatta tataaaatat ctgaccgatg cccgtttaat gaatatgtta tatccggtag
     9661 gcgaatcgtt tccgaaaaaa ccatctaccg tgtatatgta caattcgaat ctgatgtacc
     9721 ccatccgtcc gatggaggta aatgtgcagg ctgtgcgcga atcttttttc tataaccagc
     9781 ttttgaaaga caatacgcta aatgagggaa tgaagaacgc acactttttg gtaaacggaa
     9841 agtataattt caggatagag gaaagtatga aagtaaaaaa caatcccgat ttatactatg
     9901 ctgtagacaa ggtcgaagta ggagaagaga atatgatccc gctttggctg tttggctttt
     9961 tatactaaga aattctttta aatactaata gtaaaagtct atgacaaaac agaagaaatt
    10021 tttgacctgt gatggtaacc aggctgctgc tcatatttca tatatgttca gcgaagtagc
    10081 cgctatctac cccatcactc cgtcgtctac aatggcagaa tatgtagacg aatgggctgc
    10141 cgccggacgt aagaacattt tcggcgaaac tgttatggta caggaaatgc aatcagaagg
    10201 tggtgctgca ggtgcagttc acggttcttt gcaggctggt gccctgactt caacttacac
    10261 ggcttctcag ggattgttgc tgatgatccc taacatgtac aagattgccg gtgagttgct
    10321 tccttgcgta ttccatgtat ctgcccgtac actggcatct catgccttgt gtatcttcgg
    10381 cgatcatcag gatgttatgt ctgctcgtca gactggtttc gcaatgttgg cagaaggttc
    10441 tgttcaggaa gttatggact tggcgggtgt agctcacctg gctactatca agtctcgcgt
    10501 tcctttcgtg aacttcttcg acggtttccg tacatctcac gaaatccaga agatcgaagc
    10561 tctggaaaat gatgacctgg ctccgctgat cgaccagaag gcgttggctg aattccgtgc
    10621 acgtgctttg aatccggaaa aaccggaagc tcgcggtatg gctgaaaacc cggatcactt
    10681 cttccagcac agagaatctt caaacaaata ctatgaagca gttcctgcta tcgtagaaga
    10741 atatatgaac gaaatctcca aactcacagg ccgtaaatat ggtttgttcg attactacgg
    10801 agcagaagat gcagaacgcg tgattatcgc aatgggttct gtaaccgaag ctgcccgcga
    10861 agctatcgac cacctgactg ctcagggtga aaaagtaggt ttggtttctg ttcatttgta
    10921 tcgtccgttc tctgctaagc acttcctggc agctgttcct aagactgcaa aacgtatcgc
    10981 agttcttgac agaacaaaag aaccgggtgc aactggcgaa cctttgtatc tggatgtaaa
    11041 agactgtttc tacggacagg ctgacgctcc ggttatcgtg ggtggccgtt atggtctggg
    11101 ttctaaagat actactccgg cacagattct tgccgtttac gaaaatctgg cattgccgat
    11161 gccgaagaat cagttcacac tgggtatcgt agacgatgtt acattcactt ctcttcctca
    11221 gaaagaagaa atcgctttgg gcggtgaagg tatgttcgaa gctaagttct acggattagg
    11281 tgctgacggt acggtgggtg ctaacaagaa ctctgtaaag attattggtg acaatacaga
    11341 caaatattgc caggcatact tctcttacga ctctaagaag tccggtggtt tcacttgttc
    11401 tcacctgcgt ttcggagatc atccgattcg ttctacttat ttggtaaata ctccgaactt
    11461 cgttgcttgt cacgttcagg cttatctgcg tatgtacgat gttactcgcg gtttgcgtga
    11521 aaatggtaca ttcctgctga acactgtatg gaatggtgaa gagttggcta aacacctgcc
    11581 gaacaaggta aaacgttatt tcgctcagaa aaatattact gtttactata tcaatgcaac
    11641 acagattgct ttggaaattg gtttgggtaa ccgtaccaat acaatccttc agtctgcatt
    11701 cttccgcatc acaggtgtaa ttcctgttga tctggctatc gaacagatga agaaattcat
    11761 cgtgaagtct tacggaaaga agggtgaaga tgtagttaac aagaactatg ctgctgtcga
    11821 tcgtggtggc gaatatactc aactgacagt tgatccggac tgggctaacc tgccggacga
    11881 tgaagttgta gcaaacaacg atcctgcttt catcaacgaa gtagttcgtc ctatcaatgc
    11941 tcaggatggt gacttgctga aagtttctgc attcgaaggt atcgaagacg gtacatggca
    12001 tcagggaaca gctaaatatg aaaaacgtgg tgtagccgct ttcgttcctg tttgggaacc
    12061 ggataactgt atccagtgta acaagtgtgc atatgtttgt cctcacgctt ctatccgtcc
    12121 gttcgtgttg gatgctgctg aacaggctgc tgctccgttc aataactctt tgaaagcaac
    12181 aggtaaacaa ttcgaaggaa tgcagttccg tattcaggta gacgttcttg actgtctggg
    12241 ttgtggtaac tgtgccgatg tttgtccggg taatccgaag aagggtggta aagcgcttaa
    12301 gatggctgct ttggaaactc aattggatga agctccgaac tgggatttct gtgctgaaaa
    12361 ggtgacaaca aaacaacatt tggttgacat caaggctaac gtgaagaact ctcagtttgc
    12421 aactccgttg tttgagttct ccggtgcttg ctccggttgt ggtgaaactc cgtacgtgaa
    12481 gttggtaact cagctgttcg gtgaccgtga aatggtagct aacgcaacag gttgttcttc
    12541 tatctattca ggttcagtac cttctactcc ttatacaaca aatgataagg gtcagggtcc
    12601 ggcttgggct aactcattgt tcgaagactt ctgcgaattc ggtctgggta tggaattggc
    12661 taacgaaaag atgcgtgcac gcctgacaaa tgcgatgaac gaaattatcg ctgccgacaa
    12721 tgctcctgct gaagctaagg aagttctgaa ggcttgggtt gaaaatcaga atgatgccga
    12781 taagacaaaa gaactggctc ctcaggtatt ggctattgct gaagaaggta tcactcacgg
    12841 gtgtccgctt agcgcacaga tcaaggagct ttctcacttc ctggtaaaac gttcacagtg
    12901 gattatcggt ggtgacggtg cttcttacga tatcggttac ggtggtcttg accatgtaat
    12961 tgcttcaggt aagaacgtta acatcctggt attggatact gaagtttatt caaatacggg
    13021 aggccagtct tctaaagcta ctccggtagg tgcaatcgct aagtttgctg cttccggtaa
    13081 gagaatccgc aagaaagacc tgggtctgat ggctacaact tacggttatg tttatgttgc
    13141 tcagatcgca atgggtgccg accaggctca gacattgaaa gcgatccgcg aagctgaagc
    13201 ttatgatggt ccttcattga tcattgctta cgctccttgt atcaaccacg gtttgaagaa
    13261 gggtatgggt aagagccagc aggaagaagc tgatgcagta gcatgtggtt actggcattt
    13321 gtggcgttac aacccggctt tggaagaaga aggcaagaat ccgttcactt tggatagcaa
    13381 agaaccggat tggagcaaat tccaggactt cctgaagggt gaagtacgtt tcgcatctct
    13441 gacaaaacaa ttcccggccg aagccgctca attgttccag gctgccgaag acaacgctaa
    13501 gtggagactt aacaactaca agcgtttggc taaacagcag tggggtgttg aagaataatt
    13561 gattatttga tcatctaaat agtaaaacgg aatcttcgaa agagggttcc gtttttttgt
    13621 ataagccaaa taaatcgtac ctttagcgaa actaaacaaa caagcaaatg gcgaaaaata
    13681 aaagcaagca gaatcagttt cagttactct ctcctgaaaa gtatattcgt ttgaaagcta
    13741 gaaatttacc gatagaggtg tgttatgttt ccgatgactg gaaagatgaa agaggggctg
    13801 tagcggaagt gatcgtagtt cgtcgtcatg ccggtggaaa ttatacattc ggagtttacg
    13861 tcgtagatac gttgtgtctg ggagtgaaac attctgtata taggtttaat gtgccaccgg
    13921 atgagtatga cgattttgtt gaaagaacgg caactgattg cggtattaaa atcagttata
    13981 atgaagctca taattttatt tatggggcta tagcgtttgc cgaagagttc gggatcaaac
    14041 cggataagag ttttgccttg acgcaatata tactggaaga ggatacggaa gagattcctt
    14101 tgattgaata taaatatggg agaggtggcc gccctcacct ggttgccgaa acttctcttg
    14161 aggcaagtaa atatatccct atactggaag aatccacagg cggcgatttc ggtcttgaga
    14221 tattggaaga tcgtgatgtg tttgatgatg atgaattcga cgacgaattc gatgatgacg
    14281 aatttgatga tgaatatgac gaggaggata ataagacaat gtaagaatat tacaataata
    14341 atatagaggg aattggttca gtttttgtca aaagtgaact atcctgtccc cgtgcttgac
    14401 acggggccgc aagagaactg gcggtatcaa aagatattat agga
//
