LOCUS       c00067_gnlPro..        14473 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BAEBLAGM_67.
ACCESSION   c00067_gnlPro..
VERSION     c00067_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 14:14:03
            Original ID  :: gnl|Prokka|BAEBLAGM_67
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 6754
            Orig. end    :: 21227
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14473
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[16754:21225]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14471
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14473
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14473
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(154..471)
                     /locus_tag="ctg67_12"
                     /transl_table=11
                     /translation="MYVIVEINGQQFKAEEGKKLFVHHIQNAESGAVVEFDKVLLVDNN
                     GEVKVGVPTVEGAKVVCEVLSPLVKGDKVLIFHKKRRKGYRKLNGHRQQFTEVSIKEIV
                     A"
     CDS             complement(833..1561)
                     /locus_tag="ctg67_13"
                     /transl_table=11
                     /translation="MIPLVLLVVFTACNNSFIDEKVSVDEVSELVDSATIAAESVPIED
                     VIPIMATSTKAEYEAIRLVNNPDSTNLVTVKEYSISTPLTKAGDYTIIKVEYNWIEDMT
                     YVTMQGVTNHEIVLNKTAVTISESVANKWGIDPGYYYVYSWKLTLVYNQSRSHEFVIGD
                     YAGVKPSDENSYGYDLVQTGSNQWTVSTIYYRYEKRSIGPNSDSVIGVYCIPVYSLNEP
                     GVDFNTFKWQYTLQGDYSSK"
     CDS             1726..2271
                     /locus_tag="ctg67_14"
                     /transl_table=11
                     /translation="VSKRWHNLFLCTKPRLSQAQALLLPKVFVSLGIKFFIMAKLHFRP
                     YIPNQTVLFPGRIDENIAANDPVRIVNTVVDNLNLDNFKKLYKATGRCPYHPKMMLKVI
                     IYAYMNNIYSCRKIEKLLLRDIHYIWLSGNEHPDFITINRFRNRVKEEINNVFTQLVLV
                     LVDKGFISLDIEYRRYQD"
     CDS             2429..3493
                     /locus_tag="ctg67_15"
                     /transl_table=11
                     /translation="MLSDIVNELKEVLEHQPVTKDKEQKKVIREKKKQVRELEEHRDKL
                     MEYDNHLDTLGERNSYSKTDPDATFMRMKEDAMRNGQTKPGYNLQIGTQNQFLIDFRLF
                     PNPTDTLTLIPFFHSFEQRYNRLPTVGVADSGYGSEENYRFMQDNGIEAFVKYNYFHKE
                     QRPRYTPNPFHAESLHYNAEEDYYVCPMGQHMNRIGTRSDKTASGYITESARYKAQRCE
                     GCPLRGSCFKARGNRIIEVNHRLNQYKRLARERLLSKEGFRHRGRRCIEPEAVFGQMKH
                     NMAYKRFRHVGEDKVTMDFAFFAIAFNIKKMCTKLLKAGKRRSTHIIFIFIRPRVAQHT
                     RNIKPYLITEEIVA"
     CDS             complement(3471..4619)
                     /locus_tag="ctg67_16"
                     /transl_table=11
                     /translation="MKNTIILILQIIILGIVSSCEKNEEGITFVDFSDNVFYEWCLSSF
                     DLDGDQELSFRELYLVTEMNIPAQYNGQTIKSLGGIENFAYLEQLTCSDNTELTSLDLS
                     KCSYLKKADCHNCNISSLNLSGCSRLEELYCYSNSLNELNLSDFESLAYLYCDFNVLTS
                     LDFTNNPDLKEISCSGNKLQGDLNLSKCTKLEALLCEKNSIELIDITECTSLKTLICYS
                     NKLTAIDVYSKALEILSCSGNDISWLHVANCENLQELYCSENPSMQILGIKGCVSLKTL
                     ECYSNNLSSLNMSDSKDLTHIDCHNNVLSSITLNSTLITYLDVSQNLLQTLDISLCPAI
                     KCLYFTLNRPLNNGGVSKLRHISFFILKIVVPLFLSMRLFLQ"
     CDS             complement(4798..5388)
                     /locus_tag="ctg67_17"
                     /transl_table=11
                     /translation="MLTNLQHYRIVLGSNSPRRKELLAGLDLKFEVEVIPGIDESYPDD
                     LTADEIPAYIARKKAEAYLEKMTDNELLITADTIVVTYGQPDRILGKPADREEAIEMLC
                     HLSGHVHEVITGVCLTTKQKTVSFSVSSAVAFSKLEKDDIIYYVDKYRPYDKAGSYGIQ
                     EWIGYVGVEAINGSFYNVMGLPVQRLYQELKKF"
     CDS             complement(5407..5928)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg67_18"
                     /sec_met_domain="HAD_2 (E-value: 4.2e-10, bitscore: 30.8,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSINYDLTKIKAFVFDVDGVLSCDVVSLHPNGDPMRTVHIKDGY
                     ALQLAVKKGYQVGIITGGYTEAVQIRFSRLGIEHIYMRSAVKIHDFNDFLQKTGLTPEE
                     VMYAGDDIPDYDVMKRVGLPVAPADAAPEIKQIAKYISLCKGGEGVARDVIEQTMKAQG
                     HWMSAEAFGW"
     CDS             complement(5921..6688)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg67_19"
                     /sec_met_domain="F420_oxidored (E-value: 7.2e-09, bitscore:
                     27.1, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIVFIGAGNLATRLSLAMQRVGMQIGQVYSHTEASARQLATRLG
                     CPWTNDLSALQEDGDLYVFSLKDTVLSDVISKVKPNNGMWVHTAGSMPMSVFEGYAQRF
                     GVLYPLQTFSKGRNVNFDVIPVFLEANTDKNADYLKNIASALSENVRFMSSEKRRSLHL
                     AAVFACNFTNHIYTLSYKLLENESIPADVLLPLIDETVSKIHSMPPAAAQTGPAIRYDE
                     NVINKHLAMLDDPDMQAIYRLLSQSIHKEAQNE"
     CDS             complement(6685..7239)
                     /locus_tag="ctg67_20"
                     /transl_table=11
                     /translation="MESFATLIKNRRSTRKFTDQLLSPEQVEMILKAALMAPASKRKNP
                     WQFVVVEDKEMLKKLAGCKPAGASFLEGCALAVVVMANVMDSDVWVEDASIASIYMQLQ
                     AEDLGLGSCWCQIRNRQTEDDADANVYVRSLLDIPYQLEVLSIIGFGYKDQERKPFDEA
                     HLQWEKIHLGTYKMPEENKEA"
     CDS             7542..9800
                     /locus_tag="ctg67_21"
                     /transl_table=11
                     /translation="MTNEKGYYSISTSPGDSVAVIFSCLGYNKAERILPSLQQDMRLNV
                     QMNYTSIDLGEVVAVGTRYQTSTLQTMNADRVKLLPDPAGGSIESLVVTFAGVSSSNEL
                     SSQYSVRGGSYDENIVYVNGLEVFRPLLIRSGQQEGLSFINPDLTEAVNFAAGGFEARY
                     GDKMSSVLDITYKKPKLFEGSASASLLGANAYVGSSIGKFTQITGVRYKTGRSLLKTMD
                     TDAEYQPDFVDLQSYMTYQLAPKWEVNFLGNLASNTFKFTPHKRETNFGTVENAQRFEV
                     YFPNSRERDKFQTIFGALTLKHNPNEKTELGLQASAFSSKEIETYDITGEYWLGDATTE
                     NDNNQNALEIARYHEHARNRLSSTIMNVGHYGSSKIKNNTLKWGATVQMEKINDRISEW
                     EKRDSAGYSLPQTGNGVNVISNLYSDNDLSTTRISGYLQDVFKFRTKQGMFTLIGGIRG
                     SYWSYNKEFIFSPRVSLGFIPNFDQNLTFRAATGIYYQSPFYKELRTTVQDAAGNDIIE
                     LNKDIKSQRSIHFILGGDYTFRAADRNFKVSADLYYKKLDDLIPYTVDNVKIRYYGENC
                     AKGHAMGIDVKFFGEFVPGTDSWISFSLMKAEQTIRDMVTVPMPNSQGYNVSLFFQDYF
                     PGYKRVKLNLKGVLSGGLPFIAPRTKYEDVKSTFRTPAYKRVDLGFSYQLAGGTDAIMD
                     RGVFRHLKNIWIGVDVFNLFDIKNVSSYYWITNIDNQQYAVPNYLTGRQLNARLIVDF"
     CDS             9855..10040
                     /locus_tag="ctg67_22"
                     /transl_table=11
                     /translation="MRSQGFHWQFCILANWQIIINEIFLDSSKRMYLCHQNKKHLSIIK
                     FLLTWKLHILNIWELQ"
     CDS             10001..10411
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg67_23"
                     /sec_met_domain="Glyoxalase_4 (E-value: 2.3e-27, bitscore:
                     86.3, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEITHIEHLGIAVKSIEACLPYYEEILGMKCYNIEEVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALDEAESKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGKK"
     CDS             10449..12002
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg67_24"
                     /sec_met_domain="CT_Btheta (E-value: 2.3e-292, bitscore:
                     960.5, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKFLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     ESLAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEEGLQLIRKLLSFLPQNNLEETPLIECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAASEDPAKATA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             12019..12909
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg67_25"
                     /sec_met_domain="OAD_gamma (E-value: 3.6e-12, bitscore:
                     37.6, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNMTNKRFGVLLLFILLVSFGAQAQRATSMRINEVLVINEDNFVD
                     DYGKRHGWIELFNTSAGTVNIAGCFLTDDKNNPKKYPIPKGDVLTQIPPHQHTLFWADG
                     EPNRGTFHVNFTLDPSKENYIALYDADGKSLIDEITIPAAQKPDVSYGRIIDGKEEWAQ
                     LTKVTPSTNNLTLDSNEKIENFKTNDSLGIGMTITAMAVVFLGLLLLFLIFKQVGKAAI
                     AASKRNAQKAGAPVNVNTPDEVSGEVFAAIATALYEMSDDNHDIEHTVLTIRKVRRAYS
                     PWSSKIYSLRETPRK"
     CDS             12932..13363
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.9; E-value:
                     3e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg67_26"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.3e-20, bitscore:
                     63.9, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNVYKVHINSVVDDIAEVEVNGTPYNVKMEKPAKKQ
                     MVTLKRPAQAPTTASGEPVVTRPAASTTQGAVKTPLPGVILQIKCNVGDTVKRGQTLLI
                     LEAMKMENNINADRDGKIIEIKVHKGDSVLEGADLVVIG"
     CDS             13368..14471
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg67_27"
                     /sec_met_domain="OAD_beta (E-value: 1.1e-145, bitscore:
                     475.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLSFLGDNLQLFLTYTGVYNATPGHIIMILVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQVGIYEQGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYIIALQMGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRLLTTKKERLIRMKPPRAVSSTEKIIFP
                     IVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDTITILLGITVGAS
                     TQATQFLTLNSIKIFGLGALSFVIATCAGVLFVKFFNLFLKQGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNV"
ORIGIN
        1 actgtacctc tctggcgaac caaaatgtta ccagctttag caacttcacc accaaaaagc
       61 ttaacaccta atcttttact ttgtgattca cggccgttct ttgaactacc cacacctttc
      121 ttatgtgcca tttcttcttt tctcctttaa acgttaagca acaatttctt taatactcac
      181 ttcagtgaac tgctgacggt gaccgttcag tttacgataa ccttttcttc tcttcttgtg
      241 gaagatcagc actttatcac cttttaccag cggagacagt acttcacata ctacctttgc
      301 gccttctact gtaggaacac ctactttaac ttctccgttg ttgtcaacca acaacacttt
      361 gtcaaactca acaacagcac cgctttctgc gttctgaatg tgatgaacga acaacttctt
      421 accttcttca gctttgaact gttgtccgtt aatttctacg attacgtaca tctgtctttt
      481 tatatttaaa caggttatgt cccgggggtg gatacatatt ccatatcact tgtttaccct
      541 ctgcggaatt tcagactgca aaagtactgt ttccgaatat attatgcaag aaatattcgt
      601 tttttttcga ttatttccta tctaagaaga aaaccacttt attataaata caaattatac
      661 gcaacaacag acctatggtt tcataccttt taaacactct tttacgttaa gctactacca
      721 aagtattata aatacacaac aatatcaata agtcctaaag taaacaataa gactattata
      781 tcaaattgtt tactttagaa ctttattcaa ccttcttttt ccttaaaaac attcactttg
      841 atgaataatc tccttgaaga gtatattgcc atttgaaggt attaaaatct acccccggct
      901 cattcaatga atatacagga atacaataga caccaataac actatctgaa tttggaccaa
      961 tactacgctt ttcgtaacga taatatatag tagaaacagt ccattgatta cttcccgttt
     1021 gcactaaatc ataaccataa gaattttcat cactaggttt gactcctgca taatcaccta
     1081 ttacaaactc atgtgatctt gattgattgt aaaccaaagt cagtttccaa gaatacacat
     1141 aataatatcc cggatcaata ccccatttat ttgcaacact ttcactgatg gtaacagctg
     1201 ttttgtttaa tacaatttca tgattagtaa caccttgcat ggtaacataa gtcatatcct
     1261 caatccaatt atactcaacc ttgataatag tatagtcacc agcttttgta agaggtgtac
     1321 ttatactata ttctttgaca gtaactaaat tagtcgaatc tggattatta actaagcgaa
     1381 tcgcttcata ttcagctttt gtcgatgttg ccataatagg gataacatct tcaataggaa
     1441 ctgattcggc agcaattgtt gcagaatcaa caagttcaga aacttcatca actgatactt
     1501 tttcatcaat aaatgaattg ttacaagctg taaacacaac taataacact aagggaatca
     1561 ttcttttcat aatacattct aattaataac aatactaata ctatttacaa aagcaaattg
     1621 atattgaata tctataaatc attatttata ttgtaataca gatttatctc cgccacctaa
     1681 atctatagct tccccattta cattacgcaa atttgttacg aggttgtgtc aaaacgctgg
     1741 cacaaccttt ttttatgcac aaagcccaga ctttcacaag cccaggcttt gttattaccc
     1801 aaagtttttg tatctttagg cataaagttt ttcattatgg caaagttaca ttttcgtcct
     1861 tacattccca accaaacagt tctttttccc ggaagaattg atgaaaacat agcagcgaat
     1921 gatccggttc gcatagttaa tacagttgtt gataatctca atcttgacaa tttcaagaag
     1981 ctttataaag caaccggtcg ttgtccttat catcctaaaa tgatgcttaa ggtgattatc
     2041 tacgcctaca tgaacaatat ctattcgtgc cgcaaaatag agaagcttct cctacgtgac
     2101 attcattata tctggctttc cggtaatgaa catccggatt ttattaccat caaccgtttc
     2161 cgtaatcgtg taaaagaaga gataaataat gtattcacgc agttggttct tgtccttgtc
     2221 gacaaaggtt tcatcagcct tgacatagaa tatcgacggt accaagattg agtccagagc
     2281 caacaaatat acttttgtct ggcgcaagac agtcgaaaag aaccgtacaa agctgatgga
     2341 taagatccgc attctcctgg agcaggtgga tgaagccata gcccaagaga actccaccaa
     2401 agacacaccc gtagagttca ctcccgccat gctctcagat atagtgaatg aacttaaaga
     2461 ggtgctggaa caccagcctg taacaaagga caaggaacaa aagaaagtca tccgggaaaa
     2521 gaagaaacaa gtccgggaac ttgaggaaca ccgtgacaag ttgatggaat acgacaacca
     2581 tcttgacact cttggagaac gcaactccta ttccaagacc gatcctgatg ccaccttcat
     2641 gcgcatgaaa gaagacgcca tgagaaacgg gcagaccaag cccggatata atctgcaaat
     2701 aggtacccag aaccaattcc tcatagactt ccgactgttt cccaatccaa ccgatacact
     2761 gaccctcata cctttcttcc actcctttga gcaacgctat aaccgcttac cgactgtcgg
     2821 tgtggcagat tccggttacg gctcggaaga aaattaccga ttcatgcaag ataatgggat
     2881 agaagccttt gtcaagtaca actacttcca taaagaacag cgtccccgtt atacccccaa
     2941 tccattccat gcggagagtc tccattacaa tgcggaagag gattattacg tttgtcctat
     3001 ggggcagcac atgaaccgta taggaaccag gagtgacaaa acagctagcg gatacatcac
     3061 cgaaagtgcc cggtataaag cacaaagatg tgaagggtgt cctttacgtg gtagttgctt
     3121 taaagcccgg gggaaccgta ttatagaagt caaccaccga ttaaaccaat acaaacggct
     3181 ggcacgggaa aggttactct cgaaagaagg cttcaggcat aggggaaggc gatgtataga
     3241 accggaagca gtttttggac aaatgaaaca caacatggca tacaaaaggt tccggcatgt
     3301 gggagaagac aaggttacaa tggactttgc cttctttgct atagctttta atatcaaaaa
     3361 gatgtgtaca aaactattaa aagcaggaaa gagaaggagt acacacatta tatttatctt
     3421 tatcagacca cgtgtggctc aacatacgag gaatattaag ccttacctaa ttactgaaga
     3481 aatagtcgca tagacaaaaa aagaggaacg actattttta agataaaaaa ggagatgtgc
     3541 cttagttttg acacaccccc attattcaaa gggcgattca aagtaaaata tagacatttg
     3601 atggcgggac ataatgaaat atccaacgtt tgaagcagat tttgtgatac atctaaataa
     3661 gtgatcagag tagagtttaa agtaatggaa gataaaacat tattatgaca atcaatatgt
     3721 gtaagatctt tggaatcaga catattcaac gatgacaaat tatttgaata gcattccaat
     3781 gttttcaagg acacacagcc tttaattcct aggatttgca ttgatggatt ttcagaacaa
     3841 tacaattcct gtaaattctc acagtttgca acatgcaacc aggatatatc atttccggaa
     3901 caggacaata tctctaaagc ctttgaataa acatcgatag cggtaagttt atttgaataa
     3961 caaatcaatg tttttaacga tgtacattct gttatatcta tcaattcaat agaattcttt
     4021 tcacaaagca aagcttccag tttagtacat ttacttaaat taagatctcc ttgcaattta
     4081 tttcctgaac aagaaatttc tttcaaatcg ggattgtttg taaagtccaa agatgtcagt
     4141 acgttgaaat cacaatacaa atacgctaaa ctttcaaaat cggaaagatt gagttcattc
     4201 aaagaattac tataacaata taactcttcc agtcgactgc atccactcag attaagtgaa
     4261 gaaatattac aattatggca atctgctttt tttaaataag aacacttact gagatctaat
     4321 gaagtcaatt ccgtattatc actacatgtt aattgttcca ggtatgcaaa attttcaatc
     4381 ccacctaacg attttattgt ttgtccgtta tactgagcag gaatattcat ttctgttacg
     4441 agataaagtt cccgaaacga taattcttga tctccgtcca agtcaaaaga gctaagacac
     4501 cattcataga aaacattgtc agaaaaatca acaaatgtta tgccttcttc attcttctca
     4561 cacgaagata ctattcctaa aataattatc tgtagaataa ggataattgt gtttttcatt
     4621 ttatctgaaa tttaatattg ttcatatttc aatacgaaca aatatctcat atgttttcag
     4681 ataatcaaaa taaaatccgc caacgggaca tatcagtcga tgaggcagct taatttatcg
     4741 gccatgccca taaatcagcc ccatcgttca ctaaatattt tcacaaggaa acaacgctta
     4801 aaactttttc aattcctgat acaaccgttg caccggcaac cccattacat tatagaatga
     4861 gccattgata gcttctaccc cgacgtaacc gatccattcc tgtatcccgt aactgccggc
     4921 tttatcatac ggacgatatt tatctacata atagataatg tcatcctttt ccagtttgga
     4981 aaaggcgact gccgaagaga cggaaaaaga aaccgttttc tgtttagtcg tcaggcaaac
     5041 gccggtgatg acttcatgta catggcccga caggtggcaa agcatctcga ttgcttcctc
     5101 acggtcggcc ggtttgccca ggatacgatc cggttgccca taagtgacaa cgattgtgtc
     5161 agccgtaatg agcaattcgt tatcagtcat tttttccaga tacgcttctg cctttttacg
     5221 ggcgatataa gcaggtatct cgtctgccgt caagtcatca ggatatgatt cgtcgatacc
     5281 gggaattact tcgacctcga atttgaggtc aagtccggcc aataattctt ttcgccgggg
     5341 tgagttagat cccagcacga ttcggtaatg ttgtaggtta gtcagcataa ttatttttca
     5401 ttgttattac catccgaacg cttctgcgct catccaatgg ccttgtgctt tcattgtttg
     5461 ttctatcaca tcgcgggcaa caccctcacc ccctttgcat aaggagatat atttcgctat
     5521 ttgcttgatt tccggggctg catccgccgg agcaaccggc aagcctaccc gcttcatcac
     5581 atcatagtcg gggatatcgt ctccggcata catgacttct tcaggcgtca atcccgtctt
     5641 ttgcaggaaa tcattgaaat cgtgtatctt tacggcactc cgcatatata tatgttcgat
     5701 acccaagcgg gaaaaacgga tttgcacagc ctccgtatag ccaccggtaa taatcccgac
     5761 ctggtaacct ttctttacag ccagttgcaa ggcataaccg tctttgatgt ggactgtgcg
     5821 catcggatca ccgttgggat gaagtgatac cacatcgcac gacagcacac cgtctacgtc
     5881 aaacacaaat gcttttatct ttgtcaggtc ataattgata ctactcattt tgggcctcct
     5941 tatgtatact ttggctaaga agccggtaga tcgcttgcat atccggatcg tccagcatag
     6001 ccaggtgttt attgatcaca ttttcatcat accggattgc cggcccggtc tgagccgcag
     6061 caggcggcat ggaatgtatt ttcgatactg tctcatcgat aagcggcaaa aggacatctg
     6121 ccggaatgga ttcgttttcc agtaacttat aagataatgt ataaatatga ttggtaaaat
     6181 tacaggcaaa gacagccgcc agatgcaaac tccggcgttt ttccgaagac atgaaacgaa
     6241 cattctcaga aagagcgctg gctatattct tcagataatc cgcattctta tccgtgtttg
     6301 cttccagaaa aacaggaatc acatcaaaat tcacattcct ccccttactg aatgtctgca
     6361 aaggataaag aactccgaaa cgttgggcat atccttcaaa tacgctcatc ggcatacttc
     6421 ctgccgtatg gacccacata ccgttattcg gtttgacctt cgatattaca tccgacaaga
     6481 cagtatcctt cagtgaaaag acatacagat cgccatcttc ctgcaaagcg gataaatcat
     6541 tcgtccacgg acaccccagt cgtgttgcca actgacgggc actcgcctct gtatggctgt
     6601 acacctgacc aatctgcata ccaacccgtt gcatggcgag cgacaaacgt gtcgccagat
     6661 ttccggctcc gataaaaact attttcatgc ttccttgttt tcttccggca ttttataagt
     6721 gcccaggtga atcttttccc attgcaaatg agcttcgtca aacggtttgc gttcctgatc
     6781 cttataaccg aaaccgataa tcgagagcac ctccagctga taaggaatat ccagcaggct
     6841 acggacatac acattggcgt ctgcatcatc ttccgtctgc cggttacgta tctggcacca
     6901 acagctgccc agacccagat cttccgcctg gagttgcata tagatagaag cgatcgaggc
     6961 gtcttccacc cagacatcgc tatccattac attcgccatt accacaacag ccagtgcaca
     7021 accttcaaga aacgaagctc cggccggctt acaaccagcc agttttttca acatttcctt
     7081 atcttccacc acaacgaact gccagggatt tttacgcttg gaagcgggtg ccatcaaagc
     7141 tgcctttaaa atcatttcga cttgttcagg tgaaagcaac tggtcggtaa acttacgcgt
     7201 gcttcttcta ttctttatca gtgttgcaaa actctccatt tttatcttat tttgtagctg
     7261 ttaattaatc atcttcattc tgtaaggaag atatttctga acaggacaaa gataaatatt
     7321 tttttacacg ctgaatatac gcttccttca tttttcgcgt tagtaaagct ataacattat
     7381 taattatgaa gattcgtgcg atagctgcac tgctatttat attagtttca atcagcgctt
     7441 ttggacaaaa gcatgttaaa atcacgggat atgttcggga tgccgacggt agtccgcttg
     7501 aacttgtgct tgttcagata aagaatacgc tgaacggggc aatgaccaat gaaaagggtt
     7561 actattcgat ctccacgtcg ccgggcgatt ccgtagcggt tattttctct tgtctgggat
     7621 ataataaggc agaacgtatt ctacccagtt tgcaacagga catgcggctg aatgtacaga
     7681 tgaactacac aagtatcgac ctgggagaag ttgttgctgt aggtacccgt taccaaacca
     7741 gtacccttca aaccatgaat gcagaccgtg tcaagctcct ccccgaccct gccggcggaa
     7801 gcatcgaaag tctcgtggtc acttttgccg gagtttcatc cagcaacgaa ttaagttccc
     7861 agtattcggt tcgcggcggt agttacgatg aaaacatagt atatgtaaac ggcctggaag
     7921 tattccgccc gttactgatc cgttccggcc agcaggaagg tctgagcttt atcaatcccg
     7981 acctgaccga agcggtcaac ttcgcagccg gaggatttga agcacggtat ggagataaaa
     8041 tgagctctgt tcttgacatc acctataaaa aacccaagtt atttgaagga tcggcctccg
     8101 ccagcttact gggagcaaac gcctatgtgg gcagttccat cggcaagttc acacaaataa
     8161 ccggtgttcg ttataagaca ggacgttcgc tactaaaaac aatggatacg gacgccgaat
     8221 accagccgga tttcgtcgat ctgcaatcat acatgactta tcagttagct ccgaaatggg
     8281 aagtaaactt tctggggaac ctggcgtcca acacgttcaa attcaccccg cataaacggg
     8341 agacaaactt cggtacggta gaaaacgccc aacggtttga agtgtatttc cccaacagcc
     8401 gcgagcggga taagttccag acaatcttcg gcgcactgac cttgaaacac aatccgaacg
     8461 agaaaacaga actgggcctc caggcatccg ctttctccag caaggaaata gaaacctatg
     8521 acatcaccgg cgaatactgg ctgggcgatg ctacaacaga aaacgacaat aaccagaatg
     8581 cccttgaaat agcccgctac catgagcatg cccgcaaccg tttaagttca accatcatga
     8641 atgtgggaca ttacggcagt agcaagatca aaaacaacac gctgaaatgg ggagccaccg
     8701 tacagatgga aaagataaac gaccgcatca gcgaatggga aaaacgcgac tcggcaggtt
     8761 actcacttcc tcaaacaggg aacggggtaa acgtgatctc caatctttat tcggacaatg
     8821 atttgtcgac tacccggata tcgggatatt tgcaggacgt tttcaagttc cgtaccaagc
     8881 aaggtatgtt cacactcatc ggcggtatcc gcggaagcta ctggagctat aacaaagaat
     8941 tcattttcag cccacgcgtt tctttaggtt ttatccctaa tttcgatcag aatctgacct
     9001 ttcgtgcagc gacaggtatc tactaccagt caccgttcta taaagaatta cgaaccaccg
     9061 tgcaggatgc cgcaggcaat gatattatcg aactgaacaa ggatatcaaa tcgcaacgtt
     9121 ccatccattt cattctcggt ggcgattata cgttccgggc agccgaccgt aactttaaag
     9181 tcagtgccga cctctattac aagaaactgg acgacctgat tccttacacc gtcgacaacg
     9241 taaagatccg gtactacgga gagaactgtg ccaaaggcca tgcaatgggt atcgatgtta
     9301 aattcttcgg tgaatttgta cccggaaccg attcatggat cagcttctcg cttatgaaag
     9361 cagagcaaac aatccgtgac atggtaaccg ttcccatgcc caacagccag ggatataacg
     9421 tatcgttatt ctttcaggat tattttcccg gatacaaacg tgtaaaactg aatctgaaag
     9481 gcgtcctctc cggcggactt ccttttattg caccacgcac gaaatacgaa gatgtgaaga
     9541 gtactttccg cacgccggcc tacaaacgtg tcgacctcgg tttctcttac cagctggccg
     9601 gaggaaccga tgcgatcatg gaccgcggag tctttcgtca cctgaaaaat atctggatcg
     9661 gagtggacgt atttaacctg ttcgatataa aaaatgtcag ttcctattac tggatcacca
     9721 acatcgacaa ccagcaatat gctgtaccga attacctgac aggccgacaa ctcaatgcac
     9781 gactgattgt cgatttctaa aaatatgcca ataagataat ttgccaatat gccgataaaa
     9841 aacaggattt gccaatgaga agtcaaggct ttcattggca attttgcata ttggcaaatt
     9901 ggcaaattat tattaatgaa atatttcttg attcttcaaa aagaatgtac ctttgccatc
     9961 aaaacaaaaa gcatttatca attattaaat tcttattgac atggaaatta cacatattga
    10021 acatctggga attgcagtaa aaagcatcga agcttgtctg ccgtattatg aagaaatttt
    10081 aggcatgaaa tgctacaaca tcgaagaagt tgctgaccaa aaagtaaaga ctgcgttctt
    10141 taaagtaggc caaacaaaaa tcgaattact tgaaccgacc agcgaagaca gcactatcgc
    10201 caaattcatc gaaaagaaag gcgaaggtat tcaccatatc gcatttgctg tacctgatgt
    10261 acaggctgca ttggacgaag ctgaatcaaa aggtgtcaaa ctgatcgaca aagctccccg
    10321 cggtggtgca gaaggtctga acattgcatt ccttcacccg aaatcaactt gcagcgtatt
    10381 gactgaactt tgcatgccgg gtaaaaaata attaatcagt tcatttctaa caacaaatca
    10441 gaaatacaat gagtaaccaa cttgaaaaag taaaagagct tatcgctctt cgcgaacaag
    10501 cccgtttagg tggtggagaa aaaagaatcg aatctcagca caagaaaggc aagtacacag
    10561 cacgcgaacg tatcgccatg ttgcttgacg aaggtagttt cgaggagttt gatatgttcg
    10621 ttcagcaccg ttgtactaac ttcggtattg aaaaaacaaa attcctgggt gatggtatcg
    10681 taaccggata tggtacgatc gacggccgtt tggtctacat cttcgcacag gacttcaccg
    10741 tattcggagg agctttgtca gaatcactgg ccatgaagat ttgtaaggta atggatcagg
    10801 ccatgaagat gggtgcccct gtcatcggct tgaacgactc aggtggagca cgtatccagg
    10861 aaggcgttaa cgctctggca ggatatgctg aaatcttcca gcgtaatatc cttgcatccg
    10921 gtgttgtacc tcagatttca ggtatcttcg gtccgtgtgc aggtggcgca gtttattctc
    10981 cggcgctgac tgactttaac atcatgacac gtggtaccag ctacatgttc ctgacaggtc
    11041 cgaaagtagt aaaaaccgtt accggtgaag acgtaactca ggaacaactg ggtggcgcaa
    11101 gcgtacacac aaccaaatcg ggtgttgccc atttcgctgt cgacacagaa gaagaaggtc
    11161 tgcaactgat ccgcaaattg ctcagcttcc ttccgcagaa caacctggaa gaaactccgc
    11221 tgatcgaatg caaagacccg atcgaccgtc tggacgatgt attgaacgac atcattcctg
    11281 acaacgctaa ccagtcatat gacatgtatg aagtaatcgg cacaatcgtt gacaacaacg
    11341 aattcctgga agtacatgct gattatgcta aaaatattat tgttggtttc gcacgtttca
    11401 acggccagtc tgttggtatc gtagctaacc agccgaaagt aatggcaggc tgtctggaca
    11461 gcaacgcttc ccgtaaggca ggccgcttcg ttcgcttctg cgacgctttc aacattcctt
    11521 tggtaacatt ggtagacgta ccgggattcc ttccgggaac aggccaggaa tacaatggtg
    11581 taatccttca cggagccaaa ttgctttacg cttacggcga agcaactgtg cctaaaatca
    11641 ctgttacatt gcgtaaatct tacggtggtg cttactgcgt gatgagttct aaacacctgc
    11701 gtggcgatat gaactacgca tggccgacag cagaaatcgc agttatgggc ccgagcggtg
    11761 ctgtagaagt tatcttcgca aaagaagttg ccgcatccga agatcctgca aaagcaacag
    11821 ccgaaaaaga agcagaatac aagaaagcat tcgcaaaccc gtacaacgca gctcaatacg
    11881 gttatatcga cgatgtgatc gaaccgcgta atacccgttt ccgtatcatt cgtgctttac
    11941 aacaattgca gacgaaaaag ttaagcaatc ctgctaagaa acatgacaat ctgcctctat
    12001 aattcttaaa acaggaaaat gaatatgact aacaaaagat ttggagtatt gctgctgttc
    12061 atcctgctcg tatcattcgg ggcacaggca cagcgtgcaa cctccatgcg aataaatgaa
    12121 gtgctggtca tcaacgaaga taatttcgtt gacgactatg gcaaacgtca cggctggata
    12181 gaattattca atacttctgc cggaacggtt aatattgcag gttgtttctt gacagacgac
    12241 aagaacaatc ctaaaaaata tccgatcccc aagggtgacg tactaactca gatccccccc
    12301 catcaacaca ctctgttctg ggcggatggt gaacctaacc gtggtacttt tcatgtcaat
    12361 ttcacgttag acccgtcaaa agaaaattat atagcacttt atgacgccga tggtaaatcc
    12421 ttgatcgacg aaataacaat tccggctgca caaaaaccgg atgttagcta tggtagaatt
    12481 attgacggaa aagaagaatg ggcacaactc acaaaagtga ctcccagcac aaacaacctg
    12541 acgttagatt ctaacgaaaa gatcgaaaac tttaagacaa atgactcttt gggtatcggt
    12601 atgactatta cagctatggc tgttgttttt ctaggcttgc tccttctttt cctgatcttc
    12661 aaacaagtcg gaaaagcagc tatcgcagcc agcaaacgta atgctcagaa agcaggggca
    12721 cctgttaatg taaatacacc ggacgaagtt tcgggcgaag tttttgcagc aatcgctaca
    12781 gctttgtatg aaatgagtga tgacaatcac gacatcgaac atacagtgct tacaatccgc
    12841 aaagttcgcc gtgcatattc tccatggagt tctaagatct atagtttacg tgaaactccc
    12901 agaaagtgat tatctctaaa aacaaacaag aatgaaaagt tttaaatata ccatcaacgg
    12961 taacgtatat aaagtacaca tcaattcagt ggtcgacgat atcgctgaag tagaagtaaa
    13021 cggtactcct tataatgtaa aaatggagaa accggcgaaa aaacaaatgg ttacactcaa
    13081 acgcccggca caggctccta ctacagccag cggcgaaccg gttgttactc gtccggcagc
    13141 atctacaacc cagggcgccg ttaaaactcc gcttccaggt gttatcctgc aaatcaaatg
    13201 caatgtaggc gacactgtga agagaggaca aactttactt atcctcgagg ctatgaagat
    13261 ggaaaacaac atcaacgctg accgcgacgg taagattatt gaaattaaag tacataaggg
    13321 agactccgta ctggaaggtg ctgatctcgt cgtaatcgga taagagtatg caagagagtt
    13381 ttttatcatt cctgggtgac aacctacagt tgttcctcac ctatacagga gtatataatg
    13441 caactccggg ccatatcatt atgatattgg ttggtttgct ctttatattc cttgcgatta
    13501 aatatgaatt tgaacccatg ttgctgatcc ctatcggatt cggtatcctg atcggtaaca
    13561 ttccttttaa agatgcaggg cttcaggtag gtatctacga acaagggtct gtacttaaca
    13621 tcctctatca aggggtaacc tccggatggt atccgccgtt gatcttcctc ggtatcgggg
    13681 cgatgaccga cttctccgct ttgatttcca atccaaagct gatgttgatc ggtgctgccg
    13741 cccagttcgg tatcttcggt gcttatatta tcgctcttca gatgggattc gaaccgaacc
    13801 aggccggtgc tatcggtatt atcggtggtg ctgacggtcc tacggctatc ttcctgtctt
    13861 ccaagctggc ccctaacctg atgggtgcta ttgcggtgtc agcctactca tatatggcgt
    13921 tggtacctat tatccagccg ccgttcatga gactgcttac aacaaagaaa gaacgtctga
    13981 tccgtatgaa accgccgaga gccgtttctt ctacagaaaa gatcatcttc ccgatcgtag
    14041 gtctgttgct gacttgcttc cttgtacctt caggtctgcc cttgctgggt atgttgttct
    14101 tcggaaacct gttgaaagaa agtggtgtaa cccgtcgtct ggctgaaaca gcccgcggtc
    14161 cgctgatcga tacaatcacc atcctgttag gtatcacagt aggtgcttct acacaggcaa
    14221 ctcagttcct gacactgaac tctatcaaga tcttcggttt aggtgcgttg tcattcgtga
    14281 ttgcaacctg tgccggtgta ttgttcgtta agttcttcaa cctgttcctg aaacaaggca
    14341 acaagatcaa tccgcttatc ggtaatgccg gtgtatctgc cgttcccgac tcagcacgta
    14401 tctctcaggt tgtaggtctg gaatatgacc cgaccaacta tctgttgatg cacgccatgg
    14461 gtccgaacgt agc
//
