LOCUS       c00012_gnlPro..        16104 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BLOBLEOB_12.
ACCESSION   c00012_gnlPro..
VERSION     c00012_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 17:29:38
            Original ID  :: gnl|Prokka|BLOBLEOB_12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16104
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16104
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[136:6104]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      137..6104
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..16104
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16104
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             137..1972
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_1"
                     /sec_met_domain="ILVD_EDD (E-value: 1.9e-215, bitscore:
                     707.6, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNPLRSSFSTEGRRMAGARALWRANGMKEEQFGKPIIAIVNSFT
                     QFVPGHTHLHEIGQLVKAESEKQGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMASMRLNIPTVFVSGGPMEAGELDGRHLDLID
                     AMIESADTSVSDERIEQVERHACPGCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     KNRIQLFRDAAKQIVENAYKYYRDGDDSVLPRNIATRQAFLNAMSLDIAMGGSTNTVLH
                     LLAVAQEAGADFHMEDIDMLSRKTPCLCKVAPNTHTYHVQDVNRAGGILGIMNELMKAG
                     LVDGSTRRADGLTLAEAVDKYAVTSPNVTEEAIRKYKSAPAHRFSIQMGSQESYYKELD
                     TDRAEGCIRDVEHAYSKDGGLAVLRGNIALDGCVVKTAGVDESIWKFSGPAKVFDSQDA
                     ACEGILGGKVVSGDVVVITYEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHISPEAASGGAIGLVRDGDIIEINIPERSINVRLSDEELAERRKAEEARGKK
                     AFTPPTRQREVSKALRAYGKMVSSADKGGVRIVED"
     CDS             2006..3709
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.6e-50, bitscore:
                     161.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LRHVLVRHEQGATHAAQGYARVSGKVGVTLVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRKPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVEYEYKKVDYVRSYQPEPDINKDRIKAAADLINEAKKPFCLVGQGVLLGG
                     AEEELKAFLQKNDIPAGSTVLGLSALPTDFPLNKGMLGMHGNVGPNRKTNECDVLIAIG
                     MRFDDRVTGDLKTYAEQAKIIHLDIDNSEIGKNVAVDVKVLGNAKHTIPMITALLEERK
                     RPEWNAEFDRDEKEEYDKVIEKELYPTEGQLKMGEVVRKVSEATGNDAVLVTDVGQNQM
                     MGVRYFKYKQTRSVVTSGGLGTMGFGLPAAMGAKFGAPDRTVCFFTGDGGMQMTIQELG
                     TIMQEKLNVKIIILNNNFLGMVRQWQELFFHERYSNTIMENPDFVAIAKAYGIAGRAVE
                     KREELDDAIAEMLNHDGAYVLVANVETCGMVYPMVPAGGSVTNMIMGDEK"
     CDS             3725..4279
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_3"
                     /sec_met_domain="ALS_ss_C (E-value: 4.8e-17, bitscore:
                     53.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKLYTVIIFSENIVGLLNQITIIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDMIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEGLIRKYNARILEMNETCVVLEKSGHYDETQALFNELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLADMERKLHEKQQ"
     CDS             4286..5011
                     /locus_tag="ctg12_4"
                     /transl_table=11
                     /translation="MEKVGLFHFVAEPYLMDFRGRVTLPMIGNYLIHAASSHAGERGFG
                     FNDMSERHTAWVLSRLAIEMKEYPTAFDKINLYTWIDEVGRLFTSRCFELADENGKTFG
                     FARSIWAAIDVETRRPTLLDIEALGKYIDERPCPIEKPGKIMPAENKAEGIPYSIKYSD
                     LDINGHFNSVKYIEHLLDLFDIDQFKTREIGRLEIAYQSEGKQGMPLMLHKAESAPDKQ
                     DMAICHEGKAICRAAVTWR"
     CDS             5061..6104
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_5"
                     /sec_met_domain="IlvN (E-value: 4.9e-47, bitscore: 150.9,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 8.2e-40, bitscore: 127.8,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQMNFGGVVENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRQGKTYEKAVEDGWVPGETLFGIEEACDKATIIMCLLSDAAVMS
                     VWPTMKPYLTAGKALYFSHGFAITWNDRTGVVPPADIDVIMVAPKGSGTSLRSMFLEGR
                     GLNSSFAIYQDATGKAMDRTLALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYANVKCGNEAQISIDSNSKPDYREKLEAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(6204..6545)
                     /locus_tag="ctg12_6"
                     /transl_table=11
                     /translation="MEARPTQKQVITSSSFWESYDNVYVQGLDLFGFYQAELYANKIKA
                     ILYELDRTYPYYPECRHLTTKSRMYRNIILDSHLIIYRITEERIEVLDIVHSASSMRKI
                     KKTRNIHIE"
     CDS             complement(6512..6748)
                     /locus_tag="ctg12_7"
                     /transl_table=11
                     /translation="MTKLSNIPVKETAAKAARTRKAKTAPTAPQWDPTRPIQFTQEEIW
                     EHIHEIEKGPFLTLDEGFKRFEAWKQDLLKSRL"
     CDS             complement(6846..7691)
                     /locus_tag="ctg12_8"
                     /transl_table=11
                     /translation="MYKGLLVVGRGIGQVMFQGNALSGLLMLIGIACSSWTLALLALAG
                     NIASTLAAYFLGYSREDIREGLYGFNGTLVGIAIGVFMRINIWSISLLLMGSALSSGIA
                     RQFNRQNKLPGYTAPFILSVWILLILCRYLFPSLMLPPVATPPEHVPNLLYAFSANIGQ
                     VMFQGNMLTGLFLLFAILLNSRLNAAYTIWGALLPLGMILLPATSIADFNMGLLGYNGV
                     LCAIAAGNHLSIRSLIRATLAILLSIGLQIGGMRLGITTLTAPFVLSVWITNLIIKDKE
                     "
     CDS             complement(7865..8038)
                     /locus_tag="ctg12_9"
                     /transl_table=11
                     /translation="LLACLLACLLACLLACLLACLLAKQLCQFTKYLSVKKVNAVYLQT
                     CVIRISYNKSQS"
     CDS             8386..8847
                     /locus_tag="ctg12_10"
                     /transl_table=11
                     /translation="MAFYKKYQQKVNGLWYPMSVTAGKPVTTDEIADRLSQISTVSRAD
                     TYAVLKDMAGVLADYMAQGRTVKIDGLGTFYYTANASKQGVKEEKDVNASQITGVRVRF
                     IPEARRSGSGRNMVRSLISDNIFWMELPANAKTTDPEQGSGDSESPDEV"
     CDS             9021..13484
                     /locus_tag="ctg12_11"
                     /transl_table=11
                     /translation="MKTSLRRFSLRLSLVAMILCLYAALPGQGLAWGQTDGEVRFGNTP
                     DPVSYGFIYDSNETTDYSHFFVSGFTEGMAVRVQLADKANPNGVRFAIWANDAESMLDL
                     VDGGCWIPDDVVSANINLRLTSSKVCDVEYTVSVYASMDMATAPLATTLHTVRYMNSSD
                     RPEISRPDRISGELNTDIPFTINVSKAGFLQGQPVQIMIYLIGSYENLSLSGENLRKES
                     GNRYYLSVPSFSASQYTLTAHATDVCGGNYEIHICDKDGNNVTFADQASFIIPIEYSAE
                     DIAALKAIAEANPLSNDLRNFIANKEYLKDRMQGDGYNVGVRWNTKLPAQVSSFFIKDY
                     RTHTVSSLDLSALTGLESVSLNGTRLKSLDVSALTKLRYLYLDGNDSLTWSTVKFPDPL
                     PDNFNVQGFTKIMAGTPVDDYNSYVTSGTEIDLSAYAEVNGVKSTYQWYRVVREPYSRT
                     EATMEAVSGKEGAFIFKGTPGEYYLCEIRNTTYYDWYMRTPEIKVARRSDDYSPVDIAA
                     LKKLAADNPNVTQLQEFVDSKGWEHENWNTYGDAVCTDWSAEELGRLTHLRIQLDWNSK
                     DTISSLDLSAFTELKYFECERFMNIEKLDLSKNTKLEHLHVYSKNLASLDLSNCPDLQY
                     FRFGTNSIGEGSYQNSKLSTVNLSGCTKLTELYLEHSPLALLDISSFKQLNRLEIEYCP
                     NLKLQGFDNATRLEYLALPHTDQFSDLLKNLPANIRHLYLQSTEYALPSSEEARHLLTL
                     GVPSNVESLDMAQYPNLTRLEVGYDNRSGLRYSTLKNYRQNVRYNGLSRYQLTSPSHPH
                     DPDLFMNGDTIDLSSEAVIDGVETVFLWVNGKYGIEEKEALKPVPGRPGVFVLDSKEEG
                     YGNYYCKMMNTKFCEITEINYRNGWQVKTSYIHVETSVPQVFAESDVVTLARIVDASNN
                     KALTEWWNSGAWQTNENSSNAQAVWNKENPRRLTELYLYQMGNSFAKEVDLLALDKLEV
                     LSLAGNRVEKLFLPKNNTVLRSLMLGGNYSLKSLIVSEYPSLEYLDVSNTGLTALDLSN
                     NKNLKELFLNWTMLDGVENGTPDLAAQLTAYGLPMSTTRIDLANFPALMSFNADGSGLE
                     FTNVENPRQMEAAFGVVRLPVGEVRPGGFVAYGETIDLSSQKMVGTSASRFTWVFGNDT
                     IDHTDSRYTITEDLTPNYQIAGNVTNPLFPGWTVQYRAWVYTCDGDANLDKQVNVQDVT
                     ATVSYILRDSANMITNFGWAEADVNYDNNVEIADVVGIVNIIRDQPVTKAGMLRAETEA
                     PVLVELDTDNFLTISSQVPVAGIYLELVGTTEELPLVGEAAKFLQASHRNGDTLRVIGY
                     SLDGRTIPSGKTRILRMPAGVTLVGASFSDAKANSLKSAGDAIVTSNAPIEAIERLDAV
                     SNYPNPFRGSTTFRYQLAEPADAVTIHVFSANGALAAVLNGLPGEVGENRHTAALTLPA
                     GVYYYRLTAKAGRGVKASNTNILIIK"
ORIGIN
        1 aaggtgtgta agaagttgtg aagtcgtaga gatatttctt aagcctttct ccatataggg
       61 aaaggctttt tttattataa ataattcaag gtagaggcgt ggataaagcg ctctacgaac
      121 aaaaaatagg aaagagatga agaatccgtt aagaagctca tttagcaccg aaggtcgtag
      181 gatggccgga gcccgtgcgc tatggcgtgc caacgggatg aaagaggaac agttcggcaa
      241 gcctattatc gctatcgtaa attcatttac ccagttcgtg ccggggcata cgcatttgca
      301 tgagatcggg caactggtca aggccgagag cgagaaacaa ggttgtttcg ccgctgaatt
      361 taatacgatc gctatcgacg acggtatcgc tatggggcac gatgggatgc tttactcgct
      421 tccttcacgc gacattatcg cggacagcgt ggaatatatg gtaaatgccc ataaggcgga
      481 cgctatggtt tgcatcagca attgcgataa gatcacgccg ggtatgctta tggcttccat
      541 gcgattaaat atcccgacgg tgttcgtgtc cggtggcccg atggaggcag gtgagctgga
      601 tggccgccat cttgatttga tcgacgcgat gattgagtct gccgatacat cggtaagcga
      661 tgagcgtatc gagcaggtgg aacgccatgc gtgtccgggt tgcggttgtt gttccggtat
      721 gtttaccgct aactctatga actgcttgaa cgaggcgatc ggtctggcgc ttccgggtaa
      781 cgggacgatc gtggctaccc ataagaaccg tatccaactt ttccgtgacg cagctaagca
      841 aatcgttgag aacgcttaca aatactatcg tgacggggat gattccgtgt tacctcgcaa
      901 catcgctacc cgtcaggctt tcttgaacgc catgtcgctg gatatcgcca tgggggggtc
      961 taccaatacg gtgcttcact tattggccgt ggcacaagaa gccggcgccg attttcatat
     1021 ggaggatatc gatatgttat cccgcaagac tccttgcctg tgtaaggtag ccccgaatac
     1081 gcacacttat catgtacaag acgtaaaccg tgccggtgga atcctcggta tcatgaacga
     1141 gttgatgaaa gccgggcttg tggatggcag cacgagacgt gcggacggcc tgaccttggc
     1201 cgaggctgtt gataaatacg ccgtcacttc cccgaacgta acggaggagg cgatccgtaa
     1261 atacaagagc gctcccgctc atcggttcag tatccagatg ggttcccaag aatcttatta
     1321 taaggaatta gatacggatc gtgccgaagg ttgtatccgt gacgtggagc acgcttattc
     1381 caaggatggc ggcttggctg ttttgagagg gaatatcgcc ttggacggat gtgtcgtaaa
     1441 aaccgccggt gtggatgaga gtatttggaa attctccggc ccggcgaaag tcttcgattc
     1501 acaggatgcc gcttgcgagg gcattttagg aggcaaggtc gtttcaggcg atgtggtcgt
     1561 catcacgtat gagggtccga aaggggggcc gggaatgcaa gagatgttat atcctacctc
     1621 ttatataaag agccgtcact taggtaagga gtgcgccttg atcacggatg gtcgtttcag
     1681 tggcggtacg tccggccttt ctatcgggca tatctctccc gaggccgctt ccggtggcgc
     1741 tatcggactg gtgagagacg gggatatcat cgagatcaat atcccggaac gttccatcaa
     1801 cgtgcggttg agcgacgagg agttggccga gcgccgtaaa gcggaagagg cacgtggaaa
     1861 gaaagccttt acgccgccga cgcgtcagcg tgaggtctcg aaagcgttga gagcgtacgg
     1921 gaagatggtt agctccgccg ataagggagg tgtaaggatt gttgaagatt aaagccaata
     1981 atatacatta aacacgttat ttcttatgga gaaacaaaag ataaccggtt cggaagcttt
     2041 gctgaaagcg ttgattgctg aaggagtaga tactatcttc ggttatcccg gaggacaggc
     2101 gatacctatt tacgacagtt tatatgatta tagggaccag ttgaggcatg tattggtgcg
     2161 ccacgagcaa ggcgctaccc atgcggctca aggatatgcc cgtgtatccg gcaaggtagg
     2221 agtgacgttg gttacttccg gcccgggcgc tacgaatacc atcacgggta tcgctgatgc
     2281 gctgatggat agtacgccaa tggtcgtaat cgccggtcaa gtaccctcgc cgttgttggg
     2341 aaccgatgct tttcaggaag tcgatgtgat tggcatcacg caaccgatca cgaaatgggc
     2401 ttatcaaatc cgcaagccgg aggagatcgc atgggctgtt tctcgtgctt tttatatcgc
     2461 ttctacaggc cgtccgggtc cagttgtgct ggatttagcg aaggacgcgc aagtagggtt
     2521 ggtggaatat gaatataaga aggtcgatta cgtacgtagt tatcaaccgg agccggatat
     2581 caataaggat cgtatcaagg ccgccgccga tttaatcaat gaggcgaaga aacccttctg
     2641 tctggtcggg cagggagtat tgttaggcgg tgcggaagag gaattgaaag cgtttctcca
     2701 aaagaatgat atacctgccg gatctacggt attgggctta tctgcgttgc caaccgattt
     2761 cccattgaac aagggaatgc tcggcatgca tggaaacgta gggccgaacc ggaaaacgaa
     2821 tgagtgtgat gtattgatcg ctatcggtat gcgtttcgac gaccgtgtga ctggcgattt
     2881 aaagacatac gctgagcaag ccaagattat ccatctggat atcgacaact cggaaatcgg
     2941 caagaatgtt gccgtggacg taaaggtgct ggggaatgcc aagcacacga taccgatgat
     3001 cacggcgttg ttggaagaac gtaaacgccc ggaatggaat gccgagttcg atcgggacga
     3061 gaaagaggaa tacgataagg taatcgagaa ggaattgtat ccgaccgagg gtcaactgaa
     3121 aatgggcgag gtagtccgta aggtttccga ggcgaccggt aacgacgctg tattggtgac
     3181 cgacgttggg cagaaccaga tgatgggcgt ccgctatttc aaatataaac aaacccgtag
     3241 cgtggtgact tccggtggtt taggtacgat gggatttggt ctgccggccg ctatgggcgc
     3301 taagttcgga gctccggatc gtacggtctg cttctttacc ggtgatgggg gtatgcagat
     3361 gacgattcag gaattgggca ctatcatgca ggagaaactg aacgtgaaga ttatcattct
     3421 taataataac ttcttaggta tggtacgtca gtggcaagaa ttgttcttcc acgagcgtta
     3481 ttcaaacacc atcatggaga atccggattt cgtggcgatc gctaaagcct atggtatcgc
     3541 cggccgtgcc gttgaaaagc gggaggaatt ggacgacgct atcgctgaga tgctaaacca
     3601 cgacggcgct tacgtgttgg tcgctaacgt ggagacttgc ggaatggtat atccgatggt
     3661 tcctgccggg ggaagcgtga caaacatgat tatgggagac gagaaataag gaggagatga
     3721 agctatgaca acaaagaaat tatataccgt tattatcttt tcagagaata tcgtaggtct
     3781 tttgaaccag ataacgatta tctttacacg ccgacagctg aacatcgaga ctctgtccgt
     3841 ctctccgtcc gctatcaagg gcatccataa gtttacgatc acgacattcg ccgatgagga
     3901 tatgatcgat aaggtggtga aacagatcga taaacgtgtg gatatcttga aggcttatta
     3961 taatacggat gaggatctgg tttatcaaga gatcgccctt tataagctaa gtaccgagct
     4021 tttcatcaag atgggaaccg tggagggatt gatccgtaaa tacaacgctc gtatcttgga
     4081 gatgaacgag acctgcgtgg tattggagaa gagtggccac tatgacgaga cacaagcctt
     4141 gttcaatgag ttgagcgaga cgatcggtgt cctgcaattc atccgctccg gacgtgtggc
     4201 tatcacgaag agcaaggtgg agcgcttgag cgatatgttg gccgatatgg agcgaaagtt
     4261 acatgaaaag caacaataat aagatatgga gaaagtagga ttatttcatt ttgtggcgga
     4321 gccgtatttg atggatttca ggggacgtgt aacgctccct atgattggta actatttgat
     4381 tcacgccgct tccagccatg ccggagagcg tgggttcggt ttcaatgata tgtcggagcg
     4441 tcatacggct tgggtgttgt cccgtctggc tatcgagatg aaggaatatc ctaccgcctt
     4501 cgataagatt aatctataca cttggatcga tgaggtcgga cgcctcttca ccagtcgttg
     4561 tttcgagctg gcggatgaga atgggaaaac ctttggattc gcccgttcta tttgggcggc
     4621 tatcgacgtg gagacccgcc gtcctacctt attggatata gaggcattgg gcaaatatat
     4681 cgacgagcgt ccgtgcccga tcgagaagcc gggcaagatc atgccggcgg agaataaggc
     4741 ggagggaatc ccgtattcga tcaaatacag cgacttggat atcaacggtc acttcaatag
     4801 cgtgaagtat atcgagcacc tgctggattt gttcgatatc gaccagttca agacccgtga
     4861 gatcggccgt ctggagatcg cctaccaatc cgagggtaaa caaggtatgc cgcttatgct
     4921 tcataaggcg gagtccgctc ccgataagca agacatggct atttgccatg agggaaaggc
     4981 gatctgtcgt gcggcggtta cttggagata ataaaagaga tacataaata ggtttttaaa
     5041 cattaatagt taaaaagaaa atggcacaaa tgaattttgg cggtgttgta gagaatgtaa
     5101 tgacccgcga ggaatttccg ttggaaaagg caagagagat attaaaagat gagacaatcg
     5161 ctgttatcgg ctatggcgta cagggaccgg gacagtcatt gaaccttcgt gacaatggct
     5221 tcaacgtaat cgttggccag cgccaaggta agacttacga gaaagcggtt gaggacggat
     5281 gggttccggg tgagactctg ttcggtatcg aggaggcttg cgacaaggcc acgatcatca
     5341 tgtgcttgtt gtccgacgct gccgtaatgt ctgtatggcc tacgatgaag ccttatctga
     5401 cagctggcaa ggccctgtat ttctctcatg gtttcgcgat cacttggaac gatcgtacgg
     5461 gcgttgttcc tcccgcggat attgacgtga tcatggtcgc tccgaagggg tctggtacgt
     5521 ctttgcgttc catgttcctt gagggtcgtg gcttgaactc ttctttcgct atctatcaag
     5581 acgctactgg caaggcgatg gatcgtacgt tggcgttggg tatcggtatc ggttccggtt
     5641 atttgtttga gacgactttc atccgtgagg ctacttccga tttgactggt gagcgtggtt
     5701 ctttgatggg cgctatccaa ggtttgttgt tggcccagta tgaggtattg cgcgagaatg
     5761 gacatactcc ttccgaggct ttcaacgaga cggtcgagga gttgactcaa tccttgatgc
     5821 ccttattcgc caagaatggt atggactgga tgtacgctaa ctgctctacg actgcccagc
     5881 gtggcgcttt ggactggatg ggtccgttcc acgacgcaat caagccggtt gtcgagaaat
     5941 tgtacgcgaa cgtaaaatgc ggtaacgagg ctcagatctc tatcgactca aactctaagc
     6001 cggattatcg tgagaaattg gaggctgaat tgaaggcatt gcgcgagagc gagatgtggc
     6061 agacagctgt tactgtacgc aagcttcgtc cggagaacaa ctgaataatt gaaaatggag
     6121 aattgagaat tgaaaattag gatagtattt aattgttgat tgatagaggc gggtcacttg
     6181 tgggtggctc gccttgcttt atgtcattcg atgtggatat tccttgtctt cttgatcttc
     6241 cgcatactgg atgcggaatg gacgatgtcc agcacctcga tgcgttcctc ggtgatgcgg
     6301 tagatgataa ggtgtgaatc caagatgatg ttccggtaca tacggctttt cgtagttagg
     6361 tgccggcatt cgggataata aggatacgtt cggtctaact cgtataagat ggcttttatc
     6421 ttgttagcgt ataattccgc ttggtagaat ccaaataagt caaggccttg aacatataca
     6481 ttatcataac tctcccaaaa tgagctactg gttataacct gcttttgagt aggtcttgct
     6541 tccatgcctc aaaacgttta aaaccttcat ccagggttag gaacggcccc ttctcaatct
     6601 catggatatg ttcccatatc tcctcttggg tgaattggat ggggcgggtg ggatcccatt
     6661 ggggggcggt cggggcggtt ttggccttgc gtgtccttgc ggccttggcc gctgtttctt
     6721 ttacggggat gttacttaat ttcgtcatag tcgtaatcct tattaattcg tgtggggcaa
     6781 atgtacggaa tatagttggt aattaatagt taataaggga taatggtttg cggatgacgc
     6841 tggaattatt ccttatcctt tattataagg tttgttatcc atacggagag tacgaaaggg
     6901 gcggtaaggg tcgtgatccc cagacgcatg ccgccaatct gtaatccgat agatagtaag
     6961 atcgccaagg ttgcccgtat caggctacgg atagaaagat ggttgcctgc tgcgatagcg
     7021 cataatacac cgttgtagcc gagcaacccc atgttaaaat cagcaatgct tgtcgctggt
     7081 agtaatatca ttcccaatgg cagcaatgcg ccccatattg tgtaggctgc gtttaagcgt
     7141 gagtttaata agatggcgaa aagaaggaat agccctgtta acatattgcc ttgaaacatc
     7201 acttgtccga tgttagcgct gaaagcataa agtaaatttg ggacatgttc gggaggagtc
     7261 gctacaggtg ggagcatcaa cgaagggaat agatatcgac ataggattaa taaaatccat
     7321 accgaaagta tgaatggggc tgtatatccc ggtagtttat tctggcgatt gaattgccgg
     7381 gcgatcccgc ttgataaggc ggatcccata agaagcagag atatcgacca gatatttatt
     7441 ctcatgaata ctccgatcgc tatacctacc agtgttccgt tgaaaccata taggccttcg
     7501 cgtatatctt cgcgagaata tccgaggaaa taggccgcca gcgtacttgc gatattgccg
     7561 gctaacgcca ataacgctaa agtccatgaa ctacaggcaa tacctatcag cattaatagt
     7621 ccggaaagag cattgccttg aaacatcact tgaccgattc cccggcctac aacgagtaat
     7681 cccttataca taccatttta gttttgactg cgaaaataac gaaaatagca caatcacgag
     7741 cgtaattcgg gcaactgtgc caagattccg gttacgatat gttttgcggc atgatcgtca
     7801 acctgtttct tttgcgtttt tttgcaaata accgcttata tttttgtttg ttaggattaa
     7861 atatctaact ttggctcttg ttataagaga tacgaatgac acaagtttgc agatatacgg
     7921 cgttaacctt ttttaccgat aaatatttgg tgaactggca taattgttta gcaagcaagc
     7981 aagcaagcaa gcaagcaagc aagcaagcaa gcaagcaagc aagcaagcaa gcaagcaagc
     8041 aagcaaattt aaattttaga tatacggaat atgcgatccc gtgtgcggag gatttcctct
     8101 gcgtgcggga tcgttgtgtt tatggcaatc cataccccgg aaaggtcatc cggacacaat
     8161 acgacacgct aagccgggaa tggcgaggga atcccggtat aagatatttt ggcagtcttc
     8221 cggaagggcg attcccgtcc gggaaagatg gttttggaag ggtcgtcacc gaacgtggtc
     8281 ggagtcgtca ctaggcagtg tctggtgacg actccgacca tgtcgggtgg cggccctcat
     8341 ttttgtctct ccccatgagc tgccgtaaac tgtaaaaatg acattatggc attttataag
     8401 aagtatcagc aaaaggtcaa cgggctttgg tatcccatgt ctgtaacggc tggcaaacca
     8461 gtcactacgg acgagatcgc cgaccgcctg tcgcagatct ccaccgtgag ccgtgccgac
     8521 acctacgccg tgttgaaaga catggcgggg gtactggcag actacatggc gcaaggtcgt
     8581 acggtgaaga tcgatgggtt gggtacgttc tactacaccg ccaacgcctc caagcagggc
     8641 gtgaaggagg agaaggacgt gaacgcctcc cagattaccg gcgtgcgcgt gcgcttcatc
     8701 cccgaggctc gtaggagtgg tagcggacgg aacatggtac gctccttgat cagcgacaac
     8761 atcttctgga tggagttgcc ggccaatgcg aagaccaccg atccggagca gggcagtgga
     8821 gattcggaga gcccggacga ggtctgatcc cgggcgtttg tgcggcgtgt tcccgccgga
     8881 gtacacctct aggtggatgt gcttgacgag aatatcgtaa cctgattatg tgcgggaatg
     8941 tcgttcggta cgaacgtgcc ggacgaccta tccctgcgtt ctaagcgtga tagaatacat
     9001 ttatttaaat ctttatgttt atgaagacat ctttacgaag attcagtttg aggttgtcgc
     9061 tggtggcgat gatcttgtgc ttgtacgccg ccttgccggg gcagggcttg gcgtgggggc
     9121 agacggatgg ggaggtacgg tttggaaata ctcctgatcc tgtttcctat ggatttattt
     9181 atgattcaaa tgaaacgacc gactactctc atttttttgt gtccggcttc acggaaggca
     9241 tggcagtccg ggtgcagttg gcggacaagg cgaatcctaa tggggtaagg tttgctattt
     9301 gggcgaatga tgcggaatct atgcttgatt tggtggacgg tggatgttgg ataccggatg
     9361 atgtggtgtc cgctaatatt aacttgaggc tgactagttc aaaggtgtgc gatgtggagt
     9421 ataccgtgag cgtgtacgca tcgatggata tggcgaccgc tcctttggct actaccttgc
     9481 atacggtacg gtatatgaat tctagcgata ggccggagat tagcagaccg gatcgtatat
     9541 ccggcgaatt aaatactgat attcccttta cgattaatgt atcgaaggct ggattcctgc
     9601 aagggcaacc tgtgcagatt atgatctatt tgatagggtc gtacgaaaat ttgagccttt
     9661 ctggggaaaa cttacggaaa gagtctggca ataggtatta tttgagtgtt ccttctttct
     9721 ccgcttcgca atatacgttg acagcccatg cgacggatgt gtgtggtgga aattatgaaa
     9781 tacatatatg tgataaggat ggaaacaatg tgacttttgc agatcaagcc tcgtttatca
     9841 tccctattga gtactctgct gaggatatcg ccgccttgaa agcgatcgcc gaggccaatc
     9901 ctttgagtaa tgacttgcgg aacttcatcg ctaacaagga gtatctgaag gatcggatgc
     9961 agggtgatgg ttataatgtg ggagtccgtt ggaatacgaa acttcctgct caagtgagta
    10021 gtttctttat taaggattat aggacacata ctgtttcttc cttggacttg tcggctttga
    10081 ccgggctgga aagcgtctct ttgaatggta ctcgattgaa gtctttggat gtatctgcgc
    10141 tgacgaaatt gaggtatttg tatttggatg gcaacgattc cctcacatgg tctactgtga
    10201 aattcccaga tccattgcct gataatttta acgtgcaagg ttttacgaaa attatggccg
    10261 gtactccggt agacgattat aattcatacg tcacctccgg tacggagatc gacctttccg
    10321 cttacgctga ggtgaatggc gtgaagtcta cgtatcaatg gtatcgtgtg gttcgggagc
    10381 cttatagcag gacggaagcc acgatggaag ccgtatccgg caaggaaggt gcttttatct
    10441 ttaagggaac gccgggcgaa tattacctct gcgagatccg taacactacg tattacgatt
    10501 ggtatatgcg tacgcccgag atcaaggtag cccgcagatc ggatgattac tctccggttg
    10561 acatcgccgc cttgaagaaa ctggccgccg acaatccgaa cgtcacccag ttgcaagagt
    10621 tcgtggacag caagggctgg gaacatgaga attggaatac gtatggggat gcggtttgta
    10681 cggactggag tgcggaggag cttggccgat tgacgcatct acgtatccaa ttggattgga
    10741 actcgaaaga tacgatctct tccctcgact taagcgcctt tactgaattg aagtatttcg
    10801 agtgcgagcg tttcatgaat atcgagaagc tggatctctc gaagaatacg aaactggagc
    10861 atttgcacgt atacagcaag aatctggctt ctttggatct ttctaattgt cctgatctgc
    10921 aatatttccg ctttggtaca aactctattg gcgagggtag ctatcagaat tcgaagctga
    10981 gtacggtcaa tttgagtggt tgtacaaagt tgacggagct ctatttggag cactcgccgc
    11041 ttgccttgct ggatatctct tctttcaagc aattgaaccg gttggagatc gaatattgtc
    11101 cgaacttgaa gttgcaaggc tttgataacg ctacacgatt ggaatactta gccttgccgc
    11161 atacagacca gttctccgat cttttgaaga acttacccgc taacatccgt catttgtatt
    11221 tacaaagtac ggagtatgcc cttccttcct ctgaggaggc gaggcattta cttacattag
    11281 gcgtgccaag taatgtggag agcttggata tggctcaata tccgaatttg acaaggttgg
    11341 aggttggtta tgataaccgt tccggcttga ggtattccac cttgaagaat taccggcaga
    11401 atgttcggta taatggattg agtcgttatc agcttacctc tccctctcat ccgcatgatc
    11461 ctgatttatt catgaacggc gatacgatcg acctttcatc cgaggccgtg atcgatggcg
    11521 tggagaccgt attcctttgg gtgaacggca agtacggtat agaagagaaa gaggctttga
    11581 agccggtacc gggtcgtccg ggcgtattcg tgctggatag caaggaggaa ggatatggca
    11641 attattattg caagatgatg aacacgaagt tctgtgagat cacggagatt aattacagaa
    11701 atggctggca ggtcaagacc tcatacatcc acgtcgagac ctccgtaccg caagtattcg
    11761 ctgagagcga cgtggttacc ttggcccgta tcgtggacgc ttccaacaac aaggcgttga
    11821 ccgagtggtg gaacagcggc gcatggcaga cgaatgagaa ctcatcaaat gcgcaagctg
    11881 tttggaacaa ggagaacccg cgccgattga cggaattata tttatatcag atgggcaaca
    11941 gctttgcaaa ggaggtagat ctcttggcgt tggataaatt ggaagtcctg tcgttggctg
    12001 gcaatcgagt ggaaaaattg ttcttgccga agaacaatac ggtattgcgt tccttgatgc
    12061 tgggtggtaa ctattccttg aaatccttga tcgtatccga atatccgtcg ttggagtatt
    12121 tggacgtatc caatacgggc ttgacggctc tcgacttgtc taacaacaag aacttaaagg
    12181 aactgttctt gaattggacg atgcttgacg gggtagagaa cggcactccg gaccttgccg
    12241 ctcaattaac cgcatatggc ttgcctatgt ccactacccg gatcgactta gcgaacttcc
    12301 cggccttgat gtctttcaat gccgatggtt cgggcttgga gttcaccaac gtggagaacc
    12361 cgcgacaaat ggaagccgcc ttcggtgttg tcaggttgcc ggtaggcgag gttcgcccgg
    12421 gaggtttcgt ggcttatggg gagacaatcg atctttcctc acaaaagatg gtaggaacat
    12481 ctgcctctcg cttcacttgg gtatttggca atgacacgat cgaccatacc gacagccgct
    12541 atacgattac ggaggacttg accccgaatt atcaaatcgc cggtaatgta accaacccat
    12601 tgttccccgg ctggacggtt cagtatcgtg cttgggttta tacttgcgac ggtgatgcga
    12661 acctcgacaa gcaggtgaac gtgcaagacg tgacggctac cgtaagctac atcttgagag
    12721 actcggctaa tatgataaca aacttcggat gggccgaggc ggacgtgaac tatgataata
    12781 atgtagagat cgccgatgtg gtcggtatcg tcaacatcat ccgcgaccag cctgttacca
    12841 aggccggcat gctacgtgcc gagaccgagg ctcccgtgtt ggtggaactg gatacggaca
    12901 acttcctgac catctccagc caggtgccgg tagccggtat ctacttggaa ctggtaggca
    12961 ctaccgagga acttccgctc gtgggtgagg ccgccaagtt cttgcaagcc tctcaccgga
    13021 atggcgacac gttgcgtgtg atcggctata gcttggacgg acggacgatt ccttcgggca
    13081 agacccgtat cttacgtatg ccggcgggcg ttaccttggt gggcgcgtcc ttctccgacg
    13141 cgaaggcgaa tagcttgaag tctgcgggag atgcgatcgt gacttccaac gccccgatag
    13201 aggcgatcga gcgcttggat gccgtgtcca actacccgaa cccgttccgc ggcagcacga
    13261 ctttccgcta tcaactggct gagccggccg acgcagtgac gatccatgta ttctctgcca
    13321 acggagcttt ggccgcagta ttgaacggtc tgcccggcga ggtaggcgag aaccggcata
    13381 ccgccgcgct tacgcttccg gccggtgtct actactatcg cttgacagcg aaagccggtc
    13441 gaggcgtgaa ggcaagtaat actaacatct taatcattaa gtaagttatg aacgtaaatc
    13501 atataaaaca attattcgta gccctcttcc tgctgttatc agcgggaacg gctaccgccg
    13561 cccagtggat gttgaagaag acggacttga acgccgcggg tagcaaggac acgcttgtct
    13621 tgggcgtgta tggtaattcc tttggtttct cttctttcca agtggatttc accttgccgg
    13681 aaggggtctt gccggatggt gcgcctattt tgggcgatgt cgcgatcgac catgcgctta
    13741 cgtggaaaca ggagaatggc agctaccgtt gcgtagtcta tagcccgaag aacacggaaa
    13801 tgaaaacccc ggagggaggc ctgctttacc ttcccgtgga attggccgct tcttttaaaa
    13861 tgggtacttt cacggctaag aacggtctct tgtccaataa gaagtccgag ggacaaacgg
    13921 taccggatat gaccgctacc ttgaaatcgt ataaagagaa ggcagatttg gtggtgaacg
    13981 tatcgggctt ggaaaaggtg atggcggatc tgaacggaaa ccccgccgag ctaagctata
    14041 cgaccgtacc ggaaggcaag gaattgacgg tcgcttacta cacggacgat gcttgtacgg
    14101 aagcggctac tgacgctgat cgcacgaaag agggcattct gtatgtaaaa ctctcctatg
    14161 cgggtgatga ggattataac gctttcgaga aggtctatgt catgagtttg accagcaaga
    14221 aggcgattgc gacgagtgga atcattgcgc ctgaggccac ctcgatcaag gaaggacaat
    14281 tactttccgc ttccttgctg tctggcggta gcgttacgga tgaaggttat accgtagtcg
    14341 gtaagttcgc ttggacggat ggaagtatcg tggttccggc tggtgaaaaa gcatattctg
    14401 ttacttttta tcctgataat tcctcttatt atgctacggc atcggtttcc gtgccggtag
    14461 cggtaaccaa gacttatacg attaccgccg tggcgtctac cggtggtgtg gtgaatgtgt
    14521 tgggtaagac ggaggataat aaatatgtag aaggacagac tgtctctttg aaagcgatcc
    14581 cgctgcctaa ctatcagttt gacggttggt cggtgacagg ctcgagcgag acgttgacca
    14641 ctggtgattc tatcgctgtc atggtagata cagacaagac ttacaccgcc aacttctcac
    14701 cgattatgca cacgttgtca atcgctgtgg aaggaaatgg tagcctgtcg gttacggcag
    14761 aagggaatga ggtgaccaac ggcgtttccc tacagcaggg gacggtcttg cagatcctcg
    14821 cgactcccga catgaacgct cagttgaagg aattgactat aaatggcgac tcgctcaagg
    14881 gggataaggt tacgctaacg aaagccttgg agatccgggc tgcgttcgag gcgaaacccg
    14941 tggagatggc acttgtcaac atccggcaga cggctcacgg ctctatctta ttatataagg
    15001 aagacggatc gccgatcgct tccggctcta ccgtgcggaa aaactcgaag gtacgggtga
    15061 tcgcgcttcc ggacgccggg tatcagttgg agggtaacgt ggccttgtcg aacgtatcgg
    15121 gtggtacgga cgatctgtat accgtgaatg gtgatatcac ggcaaccgcc tctttcacgg
    15181 agaaaaagta taaggtggcc gcttctgccg tgagcagcaa cccgggtgag acgactgccg
    15241 ccggcaagat caccttggat aaggtaggcg agcagccgta tggcacggag gtacgtatcc
    15301 tagatgtcga gggacaagac ggagcacgct tgcttacgat cttggcgaat ggtaaggaag
    15361 ttgcccagaa tgaggtcttg actgtgaccg gcgatttgac agtaacggcc gtattcgatc
    15421 atcgggtggc gatcaagaag gaatatatca tgtggcctta ccaagaatat tactacaatg
    15481 gtgtgtctcg taatttcgtg cctttcgctt cccaaaccta tgcgggcttc tcgttcgagg
    15541 tattatataa ggactcggaa gagaatgtga ccaagaaggc gatcgatgcg gatcattata
    15601 ccgtcttgtt gcatcgtgat gaggatggcc tgtacaaaga gttcaacgag acctatgagg
    15661 atggcttggt catcaagaag tctaaaattg cggtgacaca ggtacttgac ggtgccgagg
    15721 gcttgaagac acgtccaggc agggatgagg tggaagtaga gattgacccg tcctatcctg
    15781 atgccgatgt gacaaaatat gtgatttctc ctaagagtac ttctgctaag aagaactacg
    15841 aaggtacggt ttattaccat tcaacgaaac cggcgaagcc attgaacttt ggtgcatctg
    15901 tcttgcgttc gggtggagag ccaaacggct atgtacgcat caccaacggc ggtatgccgt
    15961 atgtggcaga gaatggcgtg gtgtctgttc ccgaaggggt aacggtacta ttggaggccg
    16021 tgcctgctgc ggggtataaa ttctctaagt gggctgatgg taatatggag aacccgagag
    16081 aatacaaggt gactgccgat gcga
//
