LOCUS       c00102_gnlPro..        14672 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BLOBLEOB_102.
ACCESSION   c00102_gnlPro..
VERSION     c00102_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 17:29:38
            Original ID  :: gnl|Prokka|BLOBLEOB_102
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1098
            Orig. end    :: 15770
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14672
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[11098:15634]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14536
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14672
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14672
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             581..1102
                     /locus_tag="ctg102_3"
                     /transl_table=11
                     /translation="MSFLELARKRCSIRKYAPKNVEQEKIDYILEAARLAPSAINYQPW
                     YFVWVQSAEGKAKLQECYPREWFKQAPYYLIVCGDHQQSWKRGDHKDHMDIDAAIATEH
                     ICLAAAEQGLGTCWVCNFDTELCRKHFKIPETIEPVVLIPFGYPSDPALFDETPKKRKP
                     IEEIIKRESF"
     CDS             1104..1670
                     /locus_tag="ctg102_4"
                     /transl_table=11
                     /translation="MLYIEVLLLAIGLSMDSLAVSVTGGAVLKSNCTAGNIIKIASVLG
                     IFQAGMTVIGYTMGLGFEKYICAFDHWIAFTLLLYLGGKMIYDSTKEEEEDGKFDPLCN
                     RTLCGLGIATSIDALAVGISLAILKSPLLLQASTIGVVTFAISAFGVYFGNRFGKRIDL
                     KLDLIGGLILIGIGTKILIEHLFFS"
     CDS             1715..3439
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ILVD_EDD"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg102_5"
                     /sec_met_domain="ILVD_EDD (E-value: 6.7e-183, bitscore:
                     599.0, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSQQLRKLAPELDSLRLGSGWKIDELSKPQIIVESSYGHSHPGS
                     AHLDKLVDEAGIGIKEKGGRAANYFVTDICDGEAQGHDGMNYSLVSRDIMAAMMEIHVK
                     ATPFDAGVFIASCDKSVPAHLMAIARLDMPAIFMPGGIMKAGPNLLTLEQIGTYSAQYE
                     RKEITEEQFMVYKRDACPDCGACSFMGTASTMQVMAEALGIALPGSALIPAHLPELKET
                     ARKAGEHALGLAREELKPSDIMTIEAFENAIMVHAAIAGSSNSLLHLPAIAHELGIQLS
                     PDLFDKIHRNIPYLLNIRPSGFWPGEYFWYAGGVPAIMKEIKEFLHLDVKTVTGRTLGE
                     NLKDLQLNGFYENCHKYLPALGVKVGDIIKPLHTPIKAQGAIAILKGNLAPEGAVVKHS
                     AISPRLMQVTLRARVFDCEENAIEAVLQKRIHPGEAVFIRYEGPKGSGMPEMFYTTEAI
                     ASDPELVETIALITDGRFSGATRGPAIGHVSPEASEGGPIALVENDDLIRIDIPARRLD
                     IIGTGGIERSAEEIEKILSERRAHWIKPESQYKKGILDIYTHNSVSPMKGAYMEFFM"
     CDS             3465..4493
                     /locus_tag="ctg102_6"
                     /transl_table=11
                     /translation="MRKNISILVSLLILSLTACSDKGQYFEERGSVFHTSYHIKYKAKQ
                     ILTDKIDSELQRFNLSLNPFNPNSTIAKVNNNEDVEVDEWFTEVFNKAEEISKKSGGAF
                     DITCAPLINLWGFGFSKMDSVTPQMIDSIKAFVGYQKVRLEGKKIIKEDPRILLNCSSI
                     AKGYACDVIARLLEKEGVKNYMVEIGGEVTMKGVNQQGDCWRVGINKPEIGTSGVTNDV
                     EEIVQLCQKGGVATSGDYRNFYIKDGKKYAHTINPATGYPAGQNILSATIVAEDCMTAD
                     AYATTFMVLGVEKAKLLAQSIPQIEYFIIYADNNGQQKVTYSKGMLEYLPNRKTLAILE
                     NP"
     CDS             4502..4879
                     /locus_tag="ctg102_7"
                     /transl_table=11
                     /translation="MKRYLNQLECKIQRAGDSLFNTTTTDNLLIFVFSGKLIIYSQEGT
                     HIAEVAKDHFMLLAQNTNHKVIASAPTRLILIHAGSLSDMIINDPEWNVEKPVVLPIPP
                     ALAHTLNQIEYYMKDKYFTLN"
     CDS             complement(4882..5463)
                     /locus_tag="ctg102_8"
                     /transl_table=11
                     /translation="MLENLKKYKIVLASNSPRRRNLLSGLDIDFEVRVIPDIDESYPDS
                     IDSMEIPLYIARSKAEAYKSTMADDELLITADTIVWTFDGVMGKPANREEAYAMLHALS
                     DHVHQVITGVCIMTKDKNVGFSVESAVCFAKLGDEEINYYLDKYKPYDKAGGYGIQEWI
                     GYIGVEAINGSFYNVMGLPVQKLYQELKHF"
     CDS             complement(5501..6022)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg102_9"
                     /sec_met_domain="HAD_2 (E-value: 9.1e-09, bitscore: 25.8,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSINYDLRKIKAFVFDVDGVLSCDVIPLHPNGDPMRTVNIKDGY
                     ALQLAVKKGYEVAIITGGYTEAVQIRFSRLGIQHIYMRSAVKVHDFKDFMEKTGLSPEQ
                     IMYAGDDIPDYEVMTQVGLPVAPADAAPEIKEIAKYISSRRGGEGVARDVIEQTMRAQG
                     HWFGEEAFGW"
     CDS             complement(6015..6782)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg102_10"
                     /sec_met_domain="F420_oxidored (E-value: 1.2e-09, bitscore:
                     28.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVVFVGAGNLATRLSLEMRKSGMSIGQVYSHTSEHAKILADELG
                     CGWTVVPEDIVEDADLYVFSLKDAVLQDVIARVKPNNGLWVHTAGSMPISVFEGLTARY
                     GVVYPLQTFSKSREVDFKKIPFFLEANSSEDEKVLGEVARALSSDVRFLSSEKRKNLHL
                     AAVFACNFTNHMYALAEKILEEQQIPGEVLLPLIDETAAKVHVMSPARAQTGPAIRYDE
                     NVINKHMAMLKDPDMRNLYELISRSIHKEARHE"
     CDS             complement(6779..7339)
                     /locus_tag="ctg102_11"
                     /transl_table=11
                     /translation="MESFATLIQNRRSTRKFTEQLLSPEQVELILKAALMAPASKRSNP
                     WQFVVVEDKEMLKKLAGCKKNGSAFLEGCALAVVVLANVMESDVWIEDASVASIYMQLQ
                     AEDLGLGSCWCQIRNRVTEDEADSNNYVRSLLDIPYQLDVLSIIGIGYKDQVRKPFDES
                     HLQWEKIHIGKFSLPEENKEAEE"
     CDS             7461..9872
                     /locus_tag="ctg102_12"
                     /transl_table=11
                     /translation="MKIRAIAALLFILISVSAFGEGRIKITGYVRDADGNPLELVNVRV
                     KNTLIGSMTNEKGYYSFSISPGDSISIIYSCLGYNKAERIIPSAQADMRLNVQMNNTSF
                     DLGEVSVTAIRKQTTTMESLNADKIKLLPDPSGGSIESLVVTFAGVSSNNELSSQYSVR
                     GGSYDENIVYVNGIEVFRPLLIRSGQQEGLSFINPDLTEAVNFAAGGFEARYGDKMSSV
                     LDITYKKPKIFEGSASASLLGANAYVGSSIGKFTQVTGFRFKSGRSILGTMDTDAEYNP
                     KFIDLQTYITYQLAPKWEINFLGNLANNNYKFTPYSRETSFGTAEHPKNFKVYFDGRER
                     DRFQTLFGALTLKHNPNENTELGLQASAFKSKEEEGYDIAGEYWLSENGAENPDDDASA
                     AMSVGRYHEHARNRLNSTVMNVGHYGMARLLNNTLKWGATVQMEKINDKISEWEKRDSS
                     GYSLPQTGNNVSVYSNLFSDNQIESTRFSAYAQDAFKFRTKQGLFTLVAGVRGSYWTYN
                     KEFLFSPRASLGFIPNFDQDLTLRFATGLYYQSPFYKELRRVDKDKNGNNITVLNKDLK
                     SQRSIHFILGGDYTFRAVDRNFKVTAEMYYKKLDNLNPYTVDNVKIRYYGENCAKGYAM
                     GLDVKFFGEFVPGTDSWISFSLMKAQQTIRETTTVPMANSQGYNISLFFQDYFPGYKRV
                     KLNLKGVLSGGLPQTIPGKGYEAGYFRTPAYKRVDIGLSYQLAGGTDAIMDRSFFRHLK
                     NIWLGLDVFNILDIKNVSSYYWITDVYNVQYAVPNYLTGRQLNVRLIVDF"
     CDS             10001..10411
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg102_13"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.8e-27, bitscore:
                     85.0, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTHIEHLGIAVKSIEACLPYYEGVLGLKCYNIEVVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALNEAEEKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGNK"
     CDS             10448..12001
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg102_14"
                     /sec_met_domain="CT_Btheta (E-value: 1.4e-292, bitscore:
                     960.5, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     EALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEDGLQLIRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             12023..12916
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg102_15"
                     /sec_met_domain="OAD_gamma (E-value: 2.3e-13, bitscore:
                     40.9, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKKIGVLLLLMVLFSMGAKAQLTTSVKLNEVLVVNEDNFVDDY
                     GKRHPWFELFNNSAGTVDLRGCFLTNDKSNPRKYMIPKGDVLTKVPPRQHLLFWADDQP
                     TKGTFHVNFTFDPNKDNYLALYDSDGTTLIDEVTIPAGQKADVSYGLDLDGVGNWSILD
                     KVTPSTNNLTLDSNAKLENFQRNDPWGIGMTITAMAVVFLGLIILYLVFKQIGNAAIKA
                     SKRNAQKAAGTGAAVSANIGQESGEIFAAIATALYEMSDDNHDIENTVLTIHKVQRSYS
                     PWSSKLYSLRQTPNKK"
     CDS             12940..13371
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.7; E-value:
                     3.5e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg102_16"
                     /sec_met_domain="Biotin_lipoyl (E-value: 9.7e-21, bitscore:
                     63.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNTYKVHINSVVDDVAEVEVNGTPYNVKMEKPAKKQ
                     MVTLKRPAQAPTNASGEPVITRQAAPSVAGAVKSPLPGVILSVDCKVGDTVKRGQKILV
                     LEAMKMENNINADRDGKIVEIKVNKGDSVLEGADLVVIG"
     CDS             13376..14536
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg102_17"
                     /sec_met_domain="OAD_beta (E-value: 9e-154, bitscore:
                     501.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLQFLGENIQIFLSYTGFANATPGHIVMLLVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQLGIYEEGSVLNILYQGVKQGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYIIALQMGFDPSQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRLLTTKKERVIRMKPPRAVSQTEKIVFP
                     IVGLLLTAFLVPSGLPLLGMLFFGNLIKESGVTRRLAETARGPLIDVITILLGITVGAS
                     TQATQFLTLNSIKIFGLGALSFVIATCAGVLFVKFFNLFLKEGNKINPLIGNSGVSAVP
                     DAARISQNVGLEYDPSNYLLMHAMGPNVAGVIGSAVAAGILLGFLG"
ORIGIN
        1 aaagatatga cccgttgtct aagacgatcc ccacgaaatt attcaacgcg acagctcgta
       61 aattctcggg aataaagaac ttacacgatt tcaattgcgg attgaaagcg tataagaatg
      121 ttgtcattaa aaatatagag gtgtataacg atatgcaccg ttacatacct tatttagcta
      181 agattgccgg atttcacaag attggcgaga aagtagtgaa acatcaagcc cgcaagtacg
      241 gaactactaa attcgggttg gatcgcttcg tgaacggtta tcttgatttg atcacgcttt
      301 ggtttacttc caaattcgga aagaaaccga tgcacttctt cggtttatgg ggaagcgcta
      361 tgttcttcat tggttttatc gctctagtaa tcgtactcag catgaaattg atctcgatgt
      421 actctggaga tctaagacct ttggttacaa gttcccccta tttctatatt tcattgacag
      481 cgatgattct gggaacccag atgttcctag cgggctttat cggggagttg atttcccgca
      541 attctccgaa tcgcaataac tataaaatag aggatgagat atgagtttcc tagaattagc
      601 gagaaaacgt tgttctatcc gaaagtatgc ccccaaaaac gtagagcaag aaaagattga
      661 ttatatccta gaagcagctc gtttggcccc ttcggcgata aattatcaac cttggtattt
      721 tgtatgggtt caaagtgcgg aaggaaaagc taaattacaa gaatgctatc cccgggaatg
      781 gttcaagcaa gcgccttatt acttaatcgt ttgcggagat catcagcaat cttggaaacg
      841 gggcgatcat aaggatcata tggatatcga tgcggctatc gccacggaac atatttgttt
      901 agccgcagcc gaacaaggat tgggaacttg ctgggtttgc aatttcgaca cggagctttg
      961 ccggaaacat tttaaaatcc cggaaacgat cgagcctgtt gtattgatac cgttcggcta
     1021 tccttccgac ccggcattat tcgatgagac tccaaagaaa cgtaagccca tagaagaaat
     1081 tattaaacgg gaatcattct agtatgttat acattgaagt tctgctacta gcgatcggct
     1141 tatccatgga tagcctagca gtatcagtta ccggcggcgc agttcttaag agtaactgca
     1201 ccgccggtaa tattattaag atagcgagtg tgctcggtat attccaagcc ggaatgaccg
     1261 tgatcggtta tacgatggga ttaggattcg aaaaatacat ttgcgccttc gaccattgga
     1321 tcgcatttac cctcttgctt tacttaggtg gaaaaatgat atacgatagc acgaaggaag
     1381 aggaggaaga cgggaaattc gatcctctat gtaaccggac actatgcgga ttgggaatag
     1441 cgacaagtat cgatgccctc gccgtaggaa tctctctggc gatcttaaaa tcaccactct
     1501 tgctgcaagc ctcgactatc ggtgttgtca ccttcgctat ctctgccttc ggtgtctatt
     1561 tcggtaaccg attcggcaag agaatcgact tgaagctgga cctcatcgga ggtttaatct
     1621 taatcggtat cggtacaaaa attttaatag agcatttatt ctttagctag ggatacctta
     1681 ttgaataaat aaccttatac attaattaat agacatgaaa agccagcaat tacgaaaact
     1741 agcgccggag ctggattcac tccggctagg cagcggttgg aaaatcgacg aattgagtaa
     1801 accgcaaatc attgtagaaa gcagttacgg acatagccat ccgggaagcg cccatctgga
     1861 taaattggtg gacgaggccg gaatcggtat aaaggaaaag gggggacgtg ccgcaaacta
     1921 cttcgtcacc gatatttgtg atggagaggc gcagggacac gatggtatga actactcatt
     1981 agtctcccgt gatatcatgg ccgccatgat ggaaattcat gtaaaagcga ctcctttcga
     2041 cgctggtgtc tttatagcca gttgcgacaa atccgtccct gcgcatttga tggcgatagc
     2101 ccggctagat atgcctgcta tattcatgcc cggtggtata atgaaagccg gtcccaacct
     2161 actcacgtta gaacaaatcg gtacctatag cgcccaatac gagcgaaagg aaataacgga
     2221 agaacaattc atggtttata agcgtgacgc atgtccggat tgtggagctt gctctttcat
     2281 gggcactgcc tctacgatgc aagtaatggc agaagcgcta ggcatcgctt taccgggttc
     2341 cgccttgatc cccgcccatt tacccgagtt aaaagaaacc gcccgaaaag ccggagaaca
     2401 tgcgctcgga ctggcgagag aagagttaaa accctccgat atcatgacga tagaagcatt
     2461 tgaaaatgcg atcatggtac atgccgccat agcgggttcc agcaacagcc tgcttcatct
     2521 tccagctatc gcccatgaac tgggaatcca gttatcaccg gatttgttcg acaagataca
     2581 tcgtaacatc ccctaccttt taaatatacg tcccagcggt ttttggcccg gcgaatattt
     2641 ctggtatgcg ggaggcgtac cggcgatcat gaaagaaatc aaggaattcc tccatctcga
     2701 tgtcaagacc gttaccggca gaacattggg agaaaactta aaagatttac agctcaacgg
     2761 cttctatgag aattgccata aatatcttcc ggccctagga gtaaaggttg gcgatattat
     2821 caaacctctc catacaccga tcaaggcaca aggagccatc gctatactga aaggaaacct
     2881 agcgcccgaa ggggcagtcg taaagcattc ggcgatttca ccccgcttga tgcaagtaac
     2941 cttgagagcg agggtattcg attgtgagga gaacgctatt gaggcggtat tacaaaagag
     3001 aatccacccg ggagaagcgg tatttatccg ttatgaagga ccgaaaggaa gtggaatgcc
     3061 ggaaatgttt tatacgacag aagccatcgc ctccgatccc gagttggtag agaccatcgc
     3121 attgatcacc gacggccgtt tctccggagc tacccgaggc ccagcgatcg ggcatgtatc
     3181 cccggaagcc tccgaggggg gaccgatcgc cttggtagag aacgatgact tgatccgtat
     3241 cgatattcct gcgagaagat tggatataat cggtaccggc ggtatcgaga gaagcgcgga
     3301 agaaatagaa aagatcctat ccgaaaggcg tgcacattgg ataaaaccag agtcacaata
     3361 taaaaaagga atccttgata tttatacaca caatagcgtc tcccccatga aaggggcata
     3421 tatggaattt tttatgtaag tttgcgacat aaaatttcat aatgatgcgc aagaatattt
     3481 ccatattagt cagcctgttg atcttatcgc ttacggcttg ctcggacaag ggccaatatt
     3541 tcgaagagag aggttctgtt tttcatacaa gttaccacat caaatacaag gccaagcaaa
     3601 tcctaaccga taagatcgac agcgagctgc aacgttttaa cctctcctta aatcctttca
     3661 accccaactc cacgatcgcg aaagtcaata ataacgagga tgtggaggta gacgaatggt
     3721 ttaccgaagt attcaataag gcggaagaaa tctccaaaaa atcaggagga gcttttgata
     3781 ttacttgcgc tccattaatt aatctatggg gattcggatt cagtaagatg gatagcgtaa
     3841 ccccgcagat gatcgatagc ataaaggctt tcgtcggtta tcaaaaagtg agattggaag
     3901 gaaagaaaat catcaaagaa gatccccgga ttctattgaa ttgttcgtcc atcgcaaaag
     3961 gttatgcttg cgatgtcatc gcccgcctgc tggaaaagga aggcgtaaag aactacatgg
     4021 tagaaatagg tggtgaggtc accatgaaag gcgtaaatca acaaggagac tgttggcgag
     4081 tcggcatcaa caagccggaa atagggacaa gcggcgtaac aaatgatgtt gaagagatcg
     4141 tacaattatg ccaaaaagga ggtgtggcta cttctggtga ctaccgaaac ttctacatca
     4201 aggatggtaa gaaatatgcc catacgatca atccggcgac cggttatccc gctggacaaa
     4261 atattcttag cgcgacaatc gtggcggaag attgtatgac agcagacgct tacgctacga
     4321 ctttcatggt tttgggagtc gagaaagcga agctactggc acaatccatc ccccaaatag
     4381 agtatttcat tatttatgcg gacaacaacg gacaacagaa agtcacctac tcaaaaggta
     4441 tgttggaata ccttcctaac agaaaaacat tggctatcct cgaaaatcct taagttccta
     4501 catgaagcgt tatctaaatc aacttgaatg caaaatacag agagccggag attccctgtt
     4561 taataccaca accacggata acctattaat cttcgtattt tcgggaaaac ttattattta
     4621 cagccaagaa gggacacata tagcggaagt ggcaaaagat catttcatgc tacttgcgca
     4681 aaacaccaat cataaggtta tagcctcagc ccctacccgc cttatcttaa tacatgcggg
     4741 cagtctatcc gacatgatca taaatgaccc ggaatggaat gtggagaaac cggtcgtctt
     4801 accgattccc ccagccttag cgcacacatt aaatcagata gaatattata tgaaggataa
     4861 atactttacc ttgaattgag attaaaaatg tttcaattcc tgataaagct tttgcacagg
     4921 taatcccatc acgttataaa agctaccatt gatagcctct accccgatat aaccgatcca
     4981 ctcctgaatg ccataccctc ccgctttatc ataaggttta tatttatcca aataataatt
     5041 aatctcttca tcacccaatt ttgcgaaaca aaccgcagat tcgacggaaa agcctacatt
     5101 tttgtccttc gtcatgatac aaacgccagt tattacctga tgtacatgat ccgacaaagc
     5161 atgaagcata gcataagctt cctcccgatt cgcaggcttc cccataaccc cgtcaaacgt
     5221 ccagacgatc gtgtccgccg tgatcagcaa ttcatcatct gccatagtcg atttataggc
     5281 ctccgctttc gaacgggcaa tatataaagg gatctccatg gagtcaatag aatccgggta
     5341 agactcgtca atatccggaa ttaccctcac ctcgaagtcg atatccagac cagataacaa
     5401 attccgtcgt ctcggagaat tagaggctaa gacgatcttg tactttttta aattctctaa
     5461 cataacctat tcgattaagc gttacacatt caccaaaatt ttaccaccca aaagcctcct
     5521 cgccgaacca gtgtccttga gcccgcatcg tttgctcgat cacgtcccta gctacgcctt
     5581 cgccacctcg ccgggaggat atatatttcg ctatctcctt gatctccgga gccgcatccg
     5641 caggtgccac cggcaatccg acttgcgtca ttacctcata atcaggaata tcatcacccg
     5701 catacatgat ttgctcagga gacaagcccg ttttttccat gaaatcctta aagtcatgca
     5761 cctttacagc gctacgcata taaatatgtt gtattcccaa acgagaaaag cgaatctgta
     5821 cggcttccgt atatccaccc gtaattatag cgacctcata acctttcttc acggccaatt
     5881 gcaaggcata gccatccttg atattgacag tacgcatcgg atcgccattc gggtgaagcg
     5941 gaatcacatc gcaggatagc accccgtcta catcaaagac aaaagccttt atttttctca
     6001 aatcatagtt tatactactc atgtcgagcc tccttatgta tacttcggct aatcagctca
     6061 tatagatttc gcatatccgg atctttaagc atagccatat gtttgtttat cacattctcg
     6121 tcatatcgta tagctggtcc cgtttgggct cgcgccggcg acattacatg taccttagcg
     6181 gctgtctcgt ctatcaaagg tagcaagacc tctcccggta tttgctgttc ttccaagatc
     6241 ttttcagcta gcgcatacat atgattcgta aaattacaag cgaaaaccgc cgctaaatgt
     6301 aagttctttc gcttctcgga ggagaggaaa cggacatcac tggagagcgc cctagccacc
     6361 tctcccagca ccttctcatc ttcagacgag ttcgcctcta aaaaaaacgg tattttcttg
     6421 aaatccacct ccctactctt actaaacgtt tgtaacggat aaaccacccc atatctagcc
     6481 gtaagacctt caaatacaga gattggcata ctccctgccg tgtgcaccca caaaccgtta
     6541 ttcggtttta cacgggcgat aacatcttgg agcacggcat ctttcaaaga gaaaacatac
     6601 aagtcggcat cttccacaat atcttccggg acaacagtcc acccacatcc caattcatcg
     6661 gctaaaatct tagcatgctc acttgtgtga ctatacactt gcccgatact cattccggac
     6721 ttacgcattt ccaacgaaag ccgggtagct aagtttccgg caccaacaaa tacgactctc
     6781 attcttccgc ctctttattt tcttccggaa gagagaactt tcctatatgt atcttctccc
     6841 attgtaaatg ggattcatca aaaggcttac gaacctgatc cttataaccg ataccaatga
     6901 tagacaagac atccaattga taaggaatat ccagcaacga acgaacataa ttattcgaat
     6961 ccgcctcatc ctctgttacc cggttccgga tctgacacca gcaactgccc aatcccaaat
     7021 cctccgcttg caattgcata taaatagaag cgaccgaagc gtcctcgatc caaacatcgc
     7081 tttccatcac attcgccaag acaaccacgg ccaaggcaca accctccaga aaagcagaac
     7141 catttttctt acacccggca agtttcttca acatttcctt atcttccacg accacgaact
     7201 gccaaggatt actacgtttt gaggccggag ccatcaacgc cgctttcaag atcagttcta
     7261 cctgctcggg tgaaagtagt tgttcggtaa acttacgtgt acttcttcta ttttgtataa
     7321 gtgttgcaaa actctccatt tttttcgttc tttgtactct tttaatatta agattcgcaa
     7381 atataaatat aattttttgc acccatatat acgtatcgtt cttttttctc gttagtattt
     7441 ttataattga acaatagatt atgaagattc gtgcgatagc cgcgctgcta tttatactta
     7501 tttccgtgag tgcctttggc gaaggccgca taaaaatcac tggttatgtc cgtgacgccg
     7561 acggtaaccc tctggaatta gtgaatgtcc gggttaagaa cacgttgatc ggctccatga
     7621 ccaacgagaa gggatattat tccttttcca tatcgccggg ggattctatc tccattattt
     7681 actcttgtct gggatataat aaagctgaac gtatcattcc ttcggcacaa gccgatatgc
     7741 gcctgaacgt acagatgaac aatacctcat ttgatttagg ggaagtatct gttactgcca
     7801 tccgcaagca gaccacgacc atggagtccc taaatgcgga caaaatcaag ttattgcccg
     7861 atccctccgg aggtagtata gagagcttgg tcgttacgtt tgccggagtc tcgtccaata
     7921 acgagttaag ttcccagtat tccgtacgtg gaggtagtta tgatgaaaat atcgtttatg
     7981 tgaatgggat cgaggtattc cgtccgcttc tgattcgctc gggacaacaa gagggcctta
     8041 gctttatcaa tccggacctg acggaggcgg tcaatttcgc cgccggtggc ttcgaggctc
     8101 gttacggaga caagatgagt tccgtgctgg atattaccta taaaaagcct aagatattcg
     8161 aaggctcagc ttctgcgagc ttgttgggcg cgaatgctta tgtaggcagt tctatcggta
     8221 aatttaccca agtaacgggt ttccgcttta aaagcggtcg gtctattttg ggtaccatgg
     8281 atacagacgc agaatacaac cctaaattta tcgatctgca aacttacatc acgtaccaat
     8341 tggcccctaa atgggaaatc aatttcttgg gaaacctcgc taacaataat tataaattca
     8401 ccccttatag ccgggaaacc tctttcggta cagccgagca tcccaagaac ttcaaagtct
     8461 atttcgacgg aagggaaaga gaccgtttcc aaaccttatt cggtgcgctt acattgaaac
     8521 acaaccccaa tgagaacaca gagttgggac ttcaagcctc cgctttcaaa agcaaggaag
     8581 aagagggata cgatatcgcc ggagaatatt ggctgagcga gaacggagcg gaaaatccgg
     8641 atgacgacgc atcagccgcc atgtccgtag gccgttatca cgagcacgca cgaaaccgtt
     8701 tgaactccac cgtcatgaat gtcgggcact atgggatggc ccgcctttta aacaatacgt
     8761 tgaaatgggg agccacggta caaatggaga aaatcaatga taagatcagt gaatgggaaa
     8821 aaagggattc ctcaggttat tctttgcccc aaaccggtaa taacgtaagt gtatattcga
     8881 acctcttttc tgataatcag atagaaagca cacgcttttc cgcttatgcg caagacgcgt
     8941 tcaaattcag gaccaagcaa ggtctgttca cgttagtcgc aggagttaga ggtagttatt
     9001 ggacttataa taaggagttc cttttcagtc cccgtgcctc attgggcttt atcccgaact
     9061 tcgaccaaga cttgacgctc cgtttcgcca ctggactgta ttatcaatcg cccttctaca
     9121 aggaattacg tagagtagac aaagataaga acggcaataa tatcacggta ttgaacaaag
     9181 atctaaagtc acaacgctcc atccatttca tattgggagg agattatacg ttccgtgccg
     9241 tagaccggaa tttcaaggtg accgccgaga tgtactataa aaagctggac aatctgaatc
     9301 cctacaccgt agataacgtc aagatccgct attacggcga gaactgcgcc aaaggttacg
     9361 ccatgggact cgatgtcaaa ttcttcggag aattcgtacc gggtaccgac tcatggatca
     9421 gcttctcctt gatgaaagcc cagcaaacca tccgggaaac aacgaccgtt cctatggcca
     9481 atagccaagg ctacaacatc tcactcttct tccaagatta tttcccgggc tataaacgag
     9541 tcaagctaaa tctgaaagga gttctatccg gaggacttcc ccagacaatc ccgggcaaag
     9601 gatacgaagc cggctatttc cgtacgcccg cctacaaacg tgtagatatc ggactctcct
     9661 atcaattggc aggaggcacg gacgctatca tggacagaag cttcttccgc catttgaaaa
     9721 acatttggct aggtctggat gtgtttaaca tattagacat caaaaacgtt agttcctact
     9781 attggataac agatgtatat aatgtccaat acgcagttcc aaactatctg accggacgtc
     9841 aattgaacgt tcgtctgatt gtcgattttt aataaaatgt atctttaaac acatttactg
     9901 ggagataaaa acaaaaaatt atttcctcat tcataaaaag tagtgtacat ttgcacacaa
     9961 tagaaacaaa catttactaa atctttaaat tattattgac atggaactta cacatatcga
    10021 acatttaggt atcgcagtga agagtatcga ggcttgttta ccctattatg aaggcgttct
    10081 tggattaaaa tgctacaata tcgaagtagt agcagaccaa aaagtaaaaa ccgcattttt
    10141 caaggtagga cagactaaga ttgaattact agagccgacc agcgaagata gcacgatcgc
    10201 gaaatttatc gagaaaaaag gtgaaggtat ccaccatatc gcattcgcgg tacctgatgt
    10261 acaggcagct ttgaacgagg ctgaggaaaa aggcgttaaa ttaatcgata aagctccccg
    10321 tggtggtgcg gaaggcttga acatcgcttt ccttcacccg aaatcaactt gcagcgtatt
    10381 gacagaactt tgcatgccgg gcaacaaata attaatccgt tcatttctaa caacaaatca
    10441 aaatacaatg agtaaccagc ttgaaaaagt aaaagagctc atcgcacttc gtgagcaagc
    10501 tcgcttgggt ggaggagaga aaagaatcga atcacagcac aaaaaaggca aatataccgc
    10561 tcgtgagcgt atcgccatgt tgcttgacga aggtagtttc gaggaattcg acatgtttgt
    10621 tcaacaccgt tgtacaaact tcggtatcga gaaaactaaa tatttaggcg atggtatcgt
    10681 aacaggttat ggtacgatcg acggacgttt ggtatatatc ttcgctcaag atttcaccgt
    10741 attcggtgga gccttgtctg aggctttggc tatgaagatc tgtaaagtaa tggatcaagc
    10801 catgaagatg ggcgctcccg ttatcggttt gaacgactcc ggtggagctc gtatccaaga
    10861 aggagtaaat gccttggcag gatacgcaga gattttccaa cgtaacatct tggcttccgg
    10921 tgttgttccc cagatttccg gtatcttcgg cccttgcgcc ggtggagccg tttattctcc
    10981 ggctttgaca gacttcaaca tcatgacacg tggtaccagc tatatgttct tgactggtcc
    11041 gaaagtcgta aaaaccgtaa caggtgagga tgtaacccaa gagcagttgg gtggagccag
    11101 cgtacacact accaaatcgg gtgtagccca tttcgctgtc gatacagaag aagatggttt
    11161 gcaattaatt cgtaaattgc tcagtttctt acctcagaac aacttagagg aaacgccgtt
    11221 agttgagtgc aaagacccga tcgatcgtct ggatgatgta ttgaacgata tcattcccga
    11281 taacgccaac caatcttacg atatgtatga ggttatcggt acgatcgtcg ataacaacga
    11341 gttcctagag gtccatgcgg actacgctaa gaatatcatc gtaggtttcg ctcgtttcaa
    11401 cggacaatcc gtcggtatcg tagctaacca gccgaaggtt atggcaggat gcttggatag
    11461 caacgcatct cgtaaagcag gtcgcttcgt tcgtttctgc gacgctttca atattccttt
    11521 ggtaacattg gttgacgttc cgggattcct tccgggtaca ggtcaggaat acaacggtgt
    11581 aatccttcat ggcgctaaat tgctttacgc ttatggtgag gctaccgttc ctaagattac
    11641 cgttacattg cgtaagtctt acggtggagc ttattgcgtg atgagttcta aacatttacg
    11701 tggtgatatg aattacgcat ggccgacagc cgagatcgcc gttatgggcc cgagcggtgc
    11761 cgtagaggtt atcttcgcca aggaagtagc agccgctgaa gatccgaaag catgcgcagc
    11821 agagaaagaa gctgaatata agaaagcatt cgctaatcct tataacgcag ctcaatacgg
    11881 ttatatcgac gatgttatcg aaccgcgtaa cactcgtttc cgtattattc gtgctttgca
    11941 gcaattgcag actaagaagt taagcaatcc tgctaagaaa catgataacc tgcctctata
    12001 atccgtaaaa caggagatga atatgataaa taagaaaata ggggtattgc tactgttaat
    12061 ggttctcttc agtatgggag ccaaggcaca gttgactacc tccgttaaat taaatgaagt
    12121 gctagttgtc aatgaagata actttgttga tgactatgga aaacgccatc catggtttga
    12181 gttgtttaat aactcagcag gtacggtgga tttacgagga tgcttcttaa cgaacgataa
    12241 aagtaatccc agaaaatata tgatcccgaa gggagatgta cttaccaaag ttcctccccg
    12301 ccagcatctt cttttttggg cagatgatca gccaacaaaa gggacatttc atgtaaactt
    12361 cacattcgat ccaaacaaag ataattatct agccttatat gattcagatg gtacaacttt
    12421 gatcgacgag gtgacaatcc ctgccgggca aaaagcagat gttagttacg gtctggatct
    12481 tgatggagta ggtaattgga gtatccttga caaagtgact cctagcacca ataatctgac
    12541 gttagattcg aatgcgaaac ttgagaactt ccaacggaac gacccatggg gtattggtat
    12601 gaccataaca gccatggcag tcgtattcct tggcttaatc attttgtatc tagtattcaa
    12661 gcagatcggt aacgcagcga tcaaagctag caagcgtaac gctcaaaaag ccgcaggaac
    12721 aggtgctgcc gtatcagcca atatcggtca agaatcaggt gaaatttttg ccgctatcgc
    12781 taccgctctt tatgagatga gcgatgacaa ccacgatatc gagaacacgg tattgactat
    12841 ccacaaggtt caacgcagct attcaccatg gagttctaag ctttattctc tgcgtcagac
    12901 tccaaataaa aagtaatcat cctaaaatcc aattgacgaa tgaaaagttt taaatatacc
    12961 attaacggta acacatataa agtacatatc aactcagttg tagatgatgt ggcagaggta
    13021 gaggtaaacg gaacccctta taacgtaaaa atggagaaac ctgcgaaaaa acaaatggtt
    13081 acattgaaac gtccggctca agctccgacc aatgccagcg gtgaacctgt tatcacccgt
    13141 caagcagctc caagtgtagc cggcgctgtt aaatctccgc tgccaggtgt aattttaagt
    13201 gtagactgta aagtcggcga tacagttaag agaggccaaa agatcttggt attggaagcc
    13261 atgaagatgg aaaacaacat caatgccgat cgtgacggta aaattgtaga aattaaagta
    13321 aacaaaggcg actctgtatt ggaaggtgca gatctcgttg taatcggtta atgatatgca
    13381 agaaagtttc ttacaattcc taggagaaaa tatccaaata tttctctcct atacaggatt
    13441 tgcgaacgcg actccagggc atatcgtgat gctattggta ggtttgctgt tcatattcct
    13501 agcgattaaa tatgaattcg agccaatgct tctgatccct attggtttcg gtatcttgat
    13561 cggaaatatc cctttcaagg atgccggatt acaattaggt atatacgaag aaggttctgt
    13621 attgaacatt ttataccaag gagtgaaaca aggttggtat ccccccttga tattcctcgg
    13681 tatcggtgcc atgacagact tctccgcttt gatatccaac cctaagttaa tgctagtcgg
    13741 agctgccgcc caatttggta ttttcggtgc ttatatcatt gcattgcaaa tgggatttga
    13801 cccaagccaa gccggtgcta tcggtattat cggaggagct gatggtccaa ctgcaatctt
    13861 cttgtcatcc aagttagctc ctaacttgat gggtgctatc gctgtatccg catactcata
    13921 tatggcattg gttcctatta tccagccacc gtttatgaga ttgcttacaa cgaagaaaga
    13981 acgtgtgata cgtatgaaac ctccaagagc cgtttcacag acggagaaaa tcgttttccc
    14041 gatcgttggc ttgttattaa cagccttctt ggtaccgtct ggtttgccat tgttaggaat
    14101 gttgttcttc ggtaacttga tcaaggaaag tggtgttact cgccgtttgg cagagacagc
    14161 ccgcggcccg ctgatcgatg ttatcacgat cttattaggc atcacggtag gtgcttctac
    14221 acaagctacc cagttcttaa cattgaactc tatcaagatt ttcggtttgg gtgcgttgtc
    14281 attcgttatc gctacttgtg ccggtgtatt gttcgttaag ttctttaacc tgttcctgaa
    14341 agaaggcaac aagatcaatc cgttgatcgg taactccggt gtatccgccg tacctgacgc
    14401 tgcccgtatt tcccagaacg taggtttgga atacgatcca agtaactact tattgatgca
    14461 cgctatgggt ccgaacgtag caggtgtaat cggttccgct gtagctgccg gtatcttgct
    14521 aggattcctt ggttaataaa acaactatct atattaaaaa aggcgaggtc cgaaaggatc
    14581 ccgccttttt atgttattgt tctcagttag cttgctctat aggaaccgga ctaatctccg
    14641 tactcgtatc ctccaccaac gttgtcccga gg
//
