LOCUS       gnlProkkaAEBIMCOL_70   15202 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AEBIMCOL_70.
ACCESSION   gnlProkkaAEBIMCOL_70
VERSION     gnlProkkaAEBIMCOL_70
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 03:42:56
            Original ID  :: gnl|Prokka|AEBIMCOL_70
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15202
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15202
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5474:5741]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5475..5741
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15202
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15202
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(68..1360)
                     /locus_tag="ctg70_1"
                     /transl_table=11
                     /translation="MKETYTEAPQPIEVYDKCDVLVVGSGAAGHSAAIAAARAGCNNIV
                     LMERYGYSGGDVTGGYVIMVPNLSWYDKSFVRGLQEEWFTRLAPIPGAVRGPALKDIGS
                     QDPVLIDAWQSIHDCVSRGGFEGAKPSCLVRAVYYETNQRKIEMDKMLLEHRDSIRVMY
                     HSWGARPIMDGSTIKGVAFESKEGRKAVMAKVVIDATGDGDIFRQTGAPYSSLADGECR
                     SSTTALVWRVAGIDWDQFEAWKRRRPQALAALRERLSKIAGFRCMPLPTNQNDMCWINN
                     WHPNLDCSTVADQTRTEIETRDTMREVLAYLKEAVPVAFRHAYLYDIAPQLGYRCSYRL
                     KGEYVMSANDFAFAKRHDDVIAWHSTICQINDCGPVEIPYRAILPQKVEGLLCPGRHLS
                     ADNVAIDWLNLIPQCVGTGQAAATSSKFSQS"
     CDS             complement(1373..2830)
                     /locus_tag="ctg70_2"
                     /transl_table=11
                     /translation="MPEYAPPVGIDAACTNQLEGPYAPPKGIDLLCENVVNTTYDQLSE
                     DNVRIFKDRLLDMTGCIFGGAIVPEDQFLADLLRRWGGIEEAPLFARKGRLPMPSAVML
                     NSITARANDFGNMFFHVLGDRIASHCGETLIPMGLTLADVYPTSGREFIANNIAAEDLT
                     ARILYTLPMRWPTDMLMVSSAAAALASRYYKLDAAKTKVALTYAATNATDPGNSYYDYC
                     QEFKYHNGASAQMGIMACELACGGWQGFADPYFGHWSLVTMQVKDGKPLPALYEKAFEG
                     LGQVWYTEESFKRGPGGIPTTAAAKCGAGVRQKILDDRGTLNPADIKLVRVFRSSSMRF
                     NYYSNPFTRRNHTNALFSFQFAACCALLHGAVKVELVQTPAIQADTYLVELAEHSTMEV
                     FDREAGRSMMKVIVEMKDGAVYEDLQDYGGSMHDYPSREFLLQKFWDQFNAYGKLPKSV
                     GEKIVELADRIETLPDMREYTQLLTLT"
     CDS             complement(2858..3211)
                     /locus_tag="ctg70_3"
                     /transl_table=11
                     /translation="MTVRYSAALTDPAVQAFMRKVTMHVAPEYSEKRKKDMNTWYARVE
                     ITARGQTFVEETDFSWGSNVDGYRLTEEEQKAQFRTCAAIVLPDDKIERAIGLILHLED
                     QPSLEELMSCLSL"
     CDS             complement(3180..4280)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 99.8; E-value:
                     2.6e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg70_4"
                     /transl_table=11
                     /translation="MKKQQKDKKVKKDRREKLRYIREVSAEQRGRILLSCLTGILGVAF
                     ALAFIYATKRVIDTATGITDDNLTHIAVLTVVLLTAQLLCGAADTWISTRMQIETGNAL
                     RHRLFSRLLQSRWNELERFHTGDVVNRVEQDTTAIVTLLTSSVPAFIVTSIQLLAAFLF
                     FYFLDPSLPWLIVAILPVFLSGSRFYMRRMKRYTHDIRNSDGRIQSVIQESLQHRIVIK
                     TLEQGERHLDKLDDLQDMLHSQVMGRTRFSLSAHMLVALAFSGGYLTAFLWGAVHLSAG
                     CITFGTMTAFLQLVGKVQRPVFDLSRLIPSVVNALTAIDRLLELERLPAEADGDSIFLA
                     STPELELKDVTFRYTPDDRPVFSRPH"
     CDS             complement(4303..5466)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg70_5"
                     /sec_met_domain="NTP_transf_5 (E-value: 2.3e-46, bitscore:
                     148.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQHAFFSLVRSGLWGTPADRQLFRSVSPDDWETVYRMANSQALLA
                     LTFDGISSLPAELRPPRVLYLKWAARTAQIEQANKRLNQLLPELNTLYREAGLHPVLLK
                     GQGIGTNYRTPLHRQCGDIDIYLGKQGQPIANRLLLQQGAIVEGEASDKHASYSLKGVH
                     IENHRIILRLNSPLANRYFQQIIRKWYPQETDYALFSETGKEDSKAVSIAIPPATFNAL
                     YIFLHAFVHFLNSGIGLRQLCDWTCLLANRHKEIDATTLLRQLQDLGLLHAAQAFGYIA
                     VTRLGLPANRLPFPLEGTKQIGEQLLEDILSTGNFGQHDNRIKPRPKGYWAGKWYTFCR
                     ATRRCNELRQFAPYEALWYPVTLIGGTIAIQINRSKGVKDKKARTKK"
     CDS             complement(5475..5741)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_6"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1e-13,
                     bitscore: 41.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.8e-16, bitscore: 48.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIKQGFILHRIGDDYIIMQDGSSNVDFSKVISLNQTSAMLWQEI
                     ENKEFDTDSVTEALTSRYDVDNESARRDAQKFIDSLDREGIIE"
     CDS             complement(5754..6194)
                     /locus_tag="ctg70_7"
                     /transl_table=11
                     /translation="MKKSIPNEILLPEVARLIKEGHTVTITVRGNSMNPFLVDRRDRVT
                     LGDFTTEQLQPGVTVLARDLTERIVFHRIIRRNGDILILQGDGNLAQTEETDIGRVMGV
                     MTEAMRKDKRYTADGKVWKLYSYWWMKLNPARRWLLALFRRI"
     CDS             complement(6221..7132)
                     /locus_tag="ctg70_8"
                     /transl_table=11
                     /translation="MDYQVGPHTFRMVKPSDFNIFKALPSLIPFITTIDTTQKVIFETE
                     IDDDETTTKRTIAKTPDDICFNWEDADCIIRPLPHSSHLVSITPRKSGKNYWMECNDNF
                     RQCFIHLPACRTETPAPENETNFVLNNFLMMLYAFNAARHHTLLMHASVVATETGKGYL
                     FLGKSGTGKSTHTGLWLQQFSDCHLLNDDNPIVHVDSLGKQATVFGSPWSGKTPCYRKE
                     SMTVGAFVRLEQAPQNEIEQERAAHAFATLLPSCSCLKQNKEIYNAIVATVTELATLAP
                     VYHLKCLPDREATELCRKTVEG"
     CDS             complement(7394..10972)
                     /locus_tag="ctg70_9"
                     /transl_table=11
                     /translation="MMKLRNLMQVACMATAALTAFSCSQEEFENSGWKGNITVNATFEG
                     AGTDTRTTVNDEYKILWQDTDALGLFCSNAESNYSNTKLEYASGAGQTSATFNGSKPSG
                     ETAVFSIYPYQQNMSVSGNTLTMTLPATLTNYNGSSNGPMYAKVTNPDNLSALSFKHMA
                     AMIKLTVNKIPAEATTFKIIASNNIAGTCTVDLTAADPILTVASNGSKEITASFTASND
                     IKSRNFYIPLPTGTYSSITAQLTNGSDKVYFTKTLNDKILGRRDILVVPPLDCVVVDAT
                     TPSALSTALADSKNLPQEAPTAATVTDIAVSGSFNTTSGSNDGIAIPVLQNSDINLTFN
                     TAPTTSTAAPLTLTDKTNTSVSAPAATATNSVSLAVPETTAEQEAPSVAITMPSTTVTL
                     AAVGNKATYNEVTATTAQQTLIINAGVTVKKLTVKGGNLKIYGKVEQLVHDAGDTTIYI
                     IKGTEASLPATIDSKFVVQSDVAVLKTAFANGEDFKLSADADITGQSVSVPAGKSVVLD
                     LNGYTLTADNSATGKIIVLGKMTLKDSSTEKKGKIVASQDYTAASYNGSLIEIAGEDAS
                     MTMESGNISAVRETPDSNGQYGVGVTDGGDFTMTGGKIEAGWFAVAGNGNYKTQNSIIN
                     ITDGELISTADYAVYLPQSGTTTISGGKVYGAAGGVCIQRGTLNVEGTALITSKGTGST
                     GNWGDGTGGLDCAAINVSGAYGIATVNIKGGTLIAEAKSLITEGTTYTPVINVTGGTFS
                     DPSALKYMKANANVNIKLTADKTCPGFKTTSGQTLTMDLGGKILTLADPTVGSTGTETN
                     SCQLLEGSNVTFKNGTLKSDNNKIMIQNYCNLTLDNMTVEDTNAQYVVSNNCGNISINN
                     TTINAGSNANQFAFDVCGYAKYTAGVTVTVSGTSVINGKVEISKSAGNTELMKLNITSG
                     TFNGDLKVDASVRTENAQSIISVSGGTFSDPSVLKYMATNATVDIKLLSNINIAKTKLA
                     TGYILNAANATANLNLNGHDIINSSETADATPFTQIFTVQNGTLNISGNGNVKCDASAT
                     AKDDGYRMVIEARGYGTVNIHGGSYYNTQKLNTQIDLIYARENGKINIYGGTFESGKYG
                     TPNNDTDGRYWVLNLKNTDKNTASIQVSGGTFINFNPANPNMDDNESYLVTGYEVTRDG
                     SVYTAAHKVGDGRKEYIVGQTSQENR"
     CDS             11254..11427
                     /locus_tag="ctg70_10"
                     /transl_table=11
                     /translation="MYILYSGLRIALSLDIQQSLTSFVYILSPLMGENHINIDVSILVV
                     IFREIFKVAKFE"
     CDS             12759..13091
                     /locus_tag="ctg70_11"
                     /transl_table=11
                     /translation="MKQLIACCGLDCENCAARIATVNNDDELREKTAKEWSVLNNTPEI
                     TAETIHCMGCRADGVKFTYCSDYCAIRKCVYEKGFNTCGDCKELDTCQVVGAVLQHAPG
                     ARENLY"
     CDS             13326..14102
                     /NRPS_PKS="Domain: oMT (51-145). E-value: 2e-11. Score:
                     34.4. Matches aSDomain: nrpspksdomains_ctg70_12_oMT.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 81.3; E-value:
                     1.3e-24)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg70_12"
                     /transl_table=11
                     /translation="MSNENKTIHDFEFNLICDFFSNMERQGPGSPEVTLKALSFVDGLT
                     DESLIADIGCGTGGQTMVLAGHVPGQITGIDLFPGFIDIFNRNARQLGLQDRVKGIVGS
                     MDALPFGEEELDMIWCEGAIYNIGFERGLKEWRKYLKPGGYIAVSESSWFTDERPAEIN
                     DFWMDAYSEMDTLPNQVTKLYKAGYLPVATFILPENCWTEHYFASKVAAQEIFRKKYAG
                     NKIAEEFSLLQMIEDELYGKYKEFYGYVFFIAKKVG"
     aSDomain        13479..13760
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg70_12_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.00E-11"
                     /label="ctg70_12_oMT.1"
                     /locus_tag="ctg70_12"
                     /protein_end="145"
                     /protein_start="51"
                     /score="34.4"
                     /tool="antismash"
                     /translation="DIGCGTGGQTMVLAGHVPGQITGIDLFPGFIDIFNRNARQLGLQD
                     RVKGIVGSMDALPFGEEELDMIWCEGAIYNIGFERGLKEWRKYLKPGGY"
     CDS             complement(14177..15046)
                     /locus_tag="ctg70_13"
                     /transl_table=11
                     /translation="MRLKISNMNISEFNINDEFIACNHITTNELNPLVEKPYHTKASIF
                     ALCTKGVLKTIINHTQFRVEANALLVIPPETFVQLLHTSDDAEIYVVIFSQQLIQSSGA
                     GKVMMDKFHIIGKHYIFPLSRTDFQLYAEFMTYLSHLYQRTESPSSLVSLQTLLTYLLQ
                     GISELCPERPRIKETPGSRHFNQYRIFIRLVHTDYVREHQVSYYALKMNMRPAALCRLV
                     KKESGYTAMEIINNTIIMDAKAQLCTANTPIKDIAVSLGFNNAAFFNKFFKRHTGIPPQ
                     KFRTSSKQ"
ORIGIN
        1 ggacagaccg gttcttcaag ctggccaccc ggatcatcgc cgagatgggc gtgcagatcg
       61 tcaagagcta cgactgcgag aacttcgagg aggtggcggc ggcctgcccg gtgcccacgc
      121 actggggaat caggttcagc cagtcgatgg ccacgttgtc tgcggacagg tgccgccccg
      181 ggcacagcag cccctccacc ttctggggca ggatggcccg gtaagggatc tccaccgggc
      241 cgcagtcgtt gatctggcag atggtggagt gccaagcgat cacatcgtcg tgccgcttgg
      301 caaaggcaaa gtcgttggca ctcataacgt actctccctt gagccggtag gaacagcggt
      361 agcccagctg gggggcgata tcatacaggt aggcgtgccg gaacgccaca ggcacggcct
      421 cctttaagta ggccagaacc tcccgcatgg tgtcccgggt ctcgatctcg gtgcgggtct
      481 ggtcggcgac ggtggagcag tccagattag ggtgccagtt gttgatccag cacatatcgt
      541 tctggttggt gggcaggggc atacagcgga agcccgcgat cttgctcagc cgctcccgca
      601 gggcggccag ggcctggggg cggcggcgtt tccaggcctc gaactgatcc cagtcaatgc
      661 ccgcgacacg ccacaccaag gcggtggtgg aggaccggca ctccccgtcc gccagggagg
      721 aataaggtgc cccggtctgg cggaagatgt cgccgtctcc ggtggcgtcg atgaccacct
      781 tggccatgac ggccttgcgg ccctccttgg actcgaacgc cacgcccttg atggtgctgc
      841 cgtccatgat gggccgggcc ccccaggagt ggtacatcac tcggatggag tccctatgct
      901 ccagcagcat tttgtccatc tcgatcttgc gctggttggt ctcgtagtac accgcccgca
      961 ccaggcagga gggcttggcc ccctcgaagc cgccccggct cacgcagtcg tggatggact
     1021 gccaggcgtc aatcagcacc gggtcttggc tgccgatgtc cttcagggcg gggccgcgca
     1081 ccgcgccggg gataggggcc agccgggtaa accactcctc ctggaggccc cggacaaagg
     1141 acttgtcata ccagctcagg ttgggcacca tgatcacata gcccccggtg acgtcgccgc
     1201 cggagtagcc gtaccgctcc atgagcacga tattgttaca gcccgcccgg gcggcggcga
     1261 tggcggcgga gtggcccgcc gccccgctgc ctaccaccag tacgtcgcat ttgtcgtaaa
     1321 cctcgatggg ctggggggct tctgtatagg tttctttcat cgtatcgctc ctttacgtta
     1381 aggtcagcag ctgggtgtat tcccgcatat cggggagggt ttcgattctg tccgccagct
     1441 ccacgatctt ctcccccacc gacttgggca gtttgccgta ggcattgaac tgatcccaga
     1501 acttttgcag caggaactcc cggctggggt agtcatgcat ggaaccgccg taatcctgaa
     1561 ggtcctcgta caccgcgccg tccttcatct ccacgatcac cttcatcatg ctccttccgg
     1621 cctcgcggtc gaacacctcc atggtggagt gctccgccag ctccaccagg tacgtgtcgg
     1681 cctggatggc aggggtctgc accagctcca cctttaccgc cccgtggagc agggcgcagc
     1741 aggcggcaaa ctggaaggag aacagggcgt tggtgtggtt ccgcctggta aagggattgg
     1801 agtagtagtt gaagcgcata ctactggagc ggaacacccg aaccagtttg atatccgccg
     1861 ggttcagcgt cccccggtca tccaggatct tctgccgcac cccagccccg cacttagcgg
     1921 cggcagtggt ggggataccg ccgggacccc gtttgaagct ctcctcggtg taccacacct
     1981 ggcccagccc ctcaaacgct ttctcgtaga gggcgggcag gggcttgccg tccttcacct
     2041 gcatggtcac cagcgaccag tggccgaaat aggggtcggc gaacccctgc cagccgccgc
     2101 aggccagctc acaggccatg atgcccatct gggcactggc cccgttgtgg tatttgaact
     2161 cctggcagta gtcatagtag gagttgccgg ggtcggtggc gttggtggcc gcataggtga
     2221 gtgccacctt ggttttggcc gcgtccagct tgtagtaccg ggaggccagg gccgccgccg
     2281 cgctggacac catgagcata tcggtgggcc agcgcatggg cagggtgtag aggatgcggg
     2341 cggtgagatc ctccgcggcg atgttgttgg cgataaactc cctgccgctg gtgggataca
     2401 catccgccag ggtcagcccc atggggatga gagtctcgcc gcagtgggag gcgatccgat
     2461 cccccagcac gtggaagaac atattgccaa agtcgttggc ccgggcggtg atgctgttga
     2521 gcatgacggc actgggcatg ggcagcctcc ccttccgggc aaacaggggg gcctcctcaa
     2581 tgccgcccca gcggcgcagg agatcggcca ggaactgatc ctcgggcaca atcgcgccgc
     2641 cgaagatgca gcccgtcatg tccagcaggc gatccttgaa aatacgtacg ttgtcttcac
     2701 tgagctggtc gtaggtggtg ttgaccacat tttcacacag gaggtcaatc cccttcggcg
     2761 gggcataggg tccctccagc tggttggtgc aggccgcgtc gatgcctacg gggggtgcgt
     2821 attccggcat gggaaccatc ctttcttctt ttgttggtca cagggacagg cagctcatca
     2881 gctcctccaa agagggctgg tcctccaggt ggaggattag gccgatggcc cgctcgatct
     2941 tgtcatcggg gagcacgatg gcggcacagg ttcggaactg ggccttctgc tcctcctccg
     3001 tgaggcggta gccgtccacg ttgctgcccc aggagaagtc ggtctcctcc acaaaggtct
     3061 ggccccgggc ggtgatctcc acccgggcgt accaggtgtt catgtctttt ttccgcttct
     3121 cggagtactc cggggccacg tgcatggtga ccttgcgcat aaacgcctga acggcggggt
     3181 cagtgagggc ggctgaatac cggacggtca tcgggagtgt agcgaaaagt cacgtctttc
     3241 agttccagtt ccggggtaga ggcgaggaat atgctgtcac catccgcttc tgccggcagt
     3301 ctttccaatt ccaatagccg gtctatggcg gtaagggcat tgactacgga aggtatcagg
     3361 cgtgagaggt cgaacacggg acgctggact tttcctacca attgcaaaaa ggcggtcatc
     3421 gttccgaagg tgatacagcc tgcgctgagg tgaacggctc cccaaagaaa agccgtgagg
     3481 tatccgccgg aaaaggcaag ggccactaac atgtgggcag aaagcgagaa acgggtacgt
     3541 cccatgactt ggctgtggag catgtcttgc aagtcatcga gtttgtccag atgccgttcg
     3601 ccttgttcca atgttttaat cactatgcga tgttgcaggc tctcttgtat gacggactgg
     3661 atgcgaccgt cactgttccg aatatcatgt gtatagcgtt tcattcgtcg catatagaaa
     3721 cggctgcctg atagaaagac gggcaggatg gcaacaatca gccatggcag tgaagggtct
     3781 aaaaagtaga agaatagaaa ggctgccagc agttgtatac tcgtgacgat gaatgccggg
     3841 acagaagagg tgagcaatgt gacgatggcg gtggtgtctt gttctacccg gttcactacg
     3901 tctccggtat ggaaacgctc caattcgttc cagcggcttt gcagtaagcg cgagaagagg
     3961 cggtggcgaa gggcgttgcc cgtctctatc tgcatacggg tacttatcca agtgtcagca
     4021 gctccgcaca gtaattgggc agtcagcagg acaacggtga gaacggcgat atgcgtcagg
     4081 ttgtcgtctg ttattccggt agcggtgtct atcacccgtt tggttgcata gataaaggct
     4141 agggcaaagg ccacgcccag aatgccggtg aggcaactta gcaggatacg tccgcgttgt
     4201 tcggcagata cctctcgaat atacctaagt ttttcacgtc tgtccttttt cacttttttg
     4261 tccttctgtt gctttttcat tccttttatt ttccgggttc ttttatttct ttgtccttgc
     4321 tttcttgtct tttactcctt ttgatcggtt tatttgtata gctatcgttc cccctatcag
     4381 agtcacggga taccagagtg cttcgtacgg tgcaaattga cgcagttcgt tgcagcgtcg
     4441 ggtggcgcgg cagaaggtgt accactttcc tgcccaatat cctttggggc gtggcttgat
     4501 gcggttatca tgttgcccga agttaccggt agacaggatg tcttccaata attgttctcc
     4561 tatctgcttg gtgccttcca aggggaaagg aagccggttg gcgggcaatc ccagtcgggt
     4621 gacggcaatg tagccgaatg cttgtgcggc atgcaatagt ccgaggtcct gcaactggcg
     4681 aagcagggtg gtggcatcta tttctttgtg gcgattggca agcagacaag tccagtcgca
     4741 tagctggcgc aggccgattc cgctgttcag gaaatgtaca aaggcatgca ggaagatata
     4801 aagtgcattg aaggtggccg gaggtatggc gatactgacg gccttcgagt cctctttccc
     4861 ggtttcggag aatagggcat agtctgtttc ctgcgggtac cattttctga taatctgctg
     4921 aaagtaccgg ttggcaagcg gactgttcag ccggaggatg atgcggtggt tctcgatgtg
     4981 tactcctttc aaactgtagc tagcatgctt gtcggacgct tctccctcga ctatggcgcc
     5041 ttgttgcagc aggaggcggt tggctatggg ttgcccttgt tttcctaaat agatgtcgat
     5101 gtctccgcat tgccggtgca agggagtgcg gtagttggtg ccgatgcctt gccctttcag
     5161 cagtacggga tgcagcccgg cttcccggta aagggtattg agttcgggca gaagctggtt
     5221 gaggcgtttg ttggcttgtt ctatctgtgc agtccgggca gcccatttca gatagaggac
     5281 gcgtggaggg cgcagttcgg ccggcagact gcttatgccg tcaaaagtca gtgcaagcag
     5341 ggcttgtgag tttgccatgc ggtacacggt ttcccagtcg tccggcgaga ccgaccggaa
     5401 gagttgtcgg tctgccggag tgccccacag gccggagcgt accaatgaaa agaaagcgtg
     5461 ttgcatatcc gtccttattc tatgattcct tcgcggtcaa gggagtcgat aaacttctgc
     5521 gcatcgcgac gggccgattc gttatctaca tcatagcggc tggtcagggc ttctgtcacg
     5581 ctgtctgtat cgaactcttt gttttctatc tcttgccaaa gcatggcgga agtttggttc
     5641 aggctgatga ctttgctgaa gtccacgttc gacgagccgt cttgcatgat gatgtagtca
     5701 tcgcctatcc ggtgcaggat aaatccttgt ttgattttca tggttatttt gttttatatt
     5761 cttctgaaca gggcgagcag ccagcggcga gcggggttta gcttcatcca ccagtaggag
     5821 tagagcttcc agactttgcc gtcggcggtg taccgtttgt cttttcgcat ggcttcggtc
     5881 atgacgccca ttacccgtcc gatgtcggtt tcttcggtct gggcgaggtt gccgtcgcct
     5941 tgcaggatga gtatgtctcc gttccgacgg atgatgcggt gaaagacgat gcgttccgtc
     6001 aggtcgcgtg ccagtacggt gacgcccggt tgcagctgtt ctgtggtgaa atcgcccagt
     6061 gtcacccggt cacggcggtc cactaagaaa ggattcatgc tgttgccccg cacggtgatg
     6121 gttactgtat gtccctcttt gatgagacgc gccacttcgg gaagcaatat ctcgttggga
     6181 atgcttttct tcatcggctg ttcagttcat cattcataac ttatccttct accgtctttc
     6241 tgcaaagttc cgtcgcttca cggtcgggta ggcatttcag atgatagacg ggtgccagcg
     6301 tggcaagttc cgtcacagtg gcgacaatgg cgttatagat ttccttgttc tgctttaggc
     6361 aagagcagga ggggaggagg gtggcgaaag catgtgctgc tctctcttgc tctatttcat
     6421 tctgcggtgc ttgttccaag cggacgaagg cgcctacggt catggattct ttccgatagc
     6481 aaggtgtctt tccgctccac ggagaaccga aaacagtggc ttgcttgccg aggctgtcca
     6541 catgtactat cggattgtca tcgttcagta gatggcagtc cgagaactgt tgcagccaga
     6601 gcccggtgtg cgtacttttg cccgtgccgc ttttccctaa gaagaggtag cctttgcctg
     6661 tttcagtagc gacaaccgag gcatgcatca gcagtgtatg gtggcgggcg gcattgaagg
     6721 catagagcat catcaagaag ttgttcagta cgaagttcgt ttcgttttcc ggagccggtg
     6781 tttctgtcct gcaggccggt aggtggatga agcattgcct gaagttatcg ttgcactcca
     6841 tccaatagtt tttcccgctt ttccgtgggg tgatggatac aaggtgtgag ctgtggggca
     6901 aagggcgaat gatgcaatcg gcatcttccc agttgaaaca tatatcatcg ggagttttcg
     6961 ctatggttcg ttttgtcgtt gtttcgtcat cgtctatctc tgtttcaaag attacttttt
     7021 gcgtcgtgtc tattgtcgtg atgaacggaa tcagtgaagg cagcgccttg aatatattga
     7081 agtcggaagg tttcaccatg cgaaaggtgt gcggtcctac ttgataatcc aatatctgta
     7141 ttctcatatg ttttgattgt tagttgttat tcatgatact ttgggctact cagaaaaata
     7201 atgaatgttt gtgtgaatga ggaagatttg agagattttt caactgtctt gttgtcattc
     7261 tttagacgcg gaggacgcag atctataaaa gaaaatccgc tgtccgccgc atctaaaaga
     7321 tagtaataag gcgattccga tatctcttcg tttggtttgc gaggatatat tgcttccttt
     7381 cttagaattt ggcttatcgg ttctcctgac ttgtttggcc aacaatatat tctttcctcc
     7441 catcaccgac tttgtgggct gctgtatata cactgccgtc acgggtaacc tcgtagcctg
     7501 ttaccaaata ggactcattg tcgtccatat tcggatttgc cgggttgaaa ttgatgaacg
     7561 ttccaccgga cacctggatg ctggcagtgt tcttgtctgt attctttaag ttcagtaccc
     7621 agtatctgcc atccgtgtcg ttgttgggtg taccatattt gccggattca aatgttcctc
     7681 catagatatt gattttccca ttctctcttg cataaatcag gtctatctgg gtgttcagtt
     7741 tctgggtgtt atagtaagaa ccaccatgaa tatttactgt cccgtatcct cgggcttcaa
     7801 ttaccatgcg ataaccatcg tctttcgctg tagcagatgc atcgcacttc acattgccgt
     7861 tgcctgaaat gtttagtgtt ccgttctgta cagtaaagat ttgtgtgaaa ggagtggcat
     7921 cagctgtttc tgaggaattg atgatgtcgt ggccattcag gtttaagttt gccgttgcgt
     7981 ttgcagcatt caatatgtag cctgtggcaa gcttcgtctt ggcgatgttg atatttgaga
     8041 gaagttttat atccacagtt gcgttggttg ccatgtactt cagtacgctt gggtcggaga
     8101 atgtacctcc ggaaacagag atgatacttt gggcattttc ggttctcacg gatgcatcta
     8161 cctttaagtc accgttgaaa gtaccgcttg tgatattcag cttcataagt tcggtatttc
     8221 ctgcactctt ggaaatttcc acttttccat tgatgacgct cgtaccgctt accgtaaccg
     8281 tgactccagc agtgtacttt gcatagccgc atacgtcgaa tgcaaattga ttcgcattgc
     8341 ttcctgcgtt gatagtggta ttgttgatgc ttatgttgcc acaattgttg cttactacgt
     8401 attgggcatt tgtgtcttct actgtcatat tatctaatgt caggttgcag tagttctgaa
     8461 tcatgatttt gttgttgtca ctcttcagcg ttccgttctt gaaagtaacg tttgaacctt
     8521 cgagtaattg acagctgttc gtttcggtgc cggtggaacc tacggtcggg tcagcaagtg
     8581 taagaatctt gccgcctaag tccatcgtca aggtttgtcc gcttgtggtc ttgaatcccg
     8641 ggcaggtctt gtcggcggtc aactttatgt tcacatttgc atttgccttc atgtacttca
     8701 gcgcgcttgg gtcggagaat gtaccgccgg taacgttgat gaccggtgta taagtggtgc
     8761 cttctgtgat gagtgacttt gcttcggcaa tcagtgtacc gcctttgatg tttactgtgg
     8821 caatgccata tgctccactt acgttgatgg cggcgcagtc cagtcctccg gtaccgtcgc
     8881 cccagttgcc ggtgctacct gtgcctttac tggtaatcaa ggctgtacct tccacattca
     8941 gagtgcctcg ttggatgcat acacctcctg cggcaccata aaccttgccg ccactgatgg
     9001 tcgttgtgcc ggattggggc agatagactg catagtcagc agtagaaatg agttctccgt
     9061 ctgtgatgtt gatgatggag ttctgcgtct tgtaattgcc gttgcctgcc actgcaaacc
     9121 atccggcttc tatcttgccg cctgtcatgg tgaagtctcc accgtccgtc actccgacgc
     9181 catattggcc gttactgtcc ggagtctctc tgactgcact gatgttgccg ctttccatgg
     9241 tcatggaggc atcttcaccg gctatttcaa tcagactgcc attataagaa gccgctgtat
     9301 aatcctggct ggcaactatc ttgcctttct tctcggtaga gctgtccttc agtgtcatct
     9361 tgcccaagac gatgattttg cctgttgcgc tgttgtcggc agtcagtgta tatccgttca
     9421 agtcaagaac cacggacttt ccggcgggta cactgacgct ttgccctgtg atgtcggcat
     9481 cggcggacaa tttaaaatct tcgccgttgg cgaaagcggt ctttaggact gccacgtcgg
     9541 attgaactac aaatttgctg tcgattgttg ccggaagtga tgcttcagtt ccttttatta
     9601 tatagattgt ggtatcgccg gcatcgtgta ccaattgttc tacctttcca tatatcttca
     9661 agttaccgcc ttttacagtc agcttcttta cggtgacgcc tgcattgata atcaatgtct
     9721 gctgggcggt agtggcagtc acttcattgt aagtggcttt attgcctact gctgccaatg
     9781 taacggtggt gcttggcatg gtgatggcta cagaaggagc ttcttgctct gctgtggttt
     9841 ccggtacagc caaggataca ctgttggtgg cagtggcggc gggagcactt acgctggtat
     9901 tggtcttgtc ggtcagcgtc aacggagcgg cagtactggt cgttggggct gtattgaacg
     9961 tcaggttgat gtccgagttc tgtaaaaccg ggatggcgat gccgtcgttg ctgccagaag
    10021 tggtattgaa gctgccgctg actgcaatgt cggttacggt tgctgctgtc ggtgcttctt
    10081 gtgggagatt ttttgaatca gctaaagctg tactaagcgc actgggggtt gtagcatcta
    10141 caacaacgca atccaaagga ggtactacca atatgtctct tctccctaag attttgtcat
    10201 taagcgtctt ggtaaaatat accttgtcgc ttccattcgt cagttgggca gtgatggaac
    10261 tataagtacc tgtgggcaaa ggaatgtaga agttgcgcga ttttatatcg tttgaagcag
    10321 tgaaggaggc agtgatttcc ttgcttccat tgcttgctac cgtcagtatc gggtctgctg
    10381 cggttaagtc taccgtacaa gtacctgcaa tgttattgga ggcaataatc ttgaaagtag
    10441 tggcctctgc cggaatcttg ttgacggtca gttttatcat ggctgccatg tgcttgaagg
    10501 acagagcgct cagattgtcg ggatttgtca ccttggcata catcgggcca ttgctgctgc
    10561 cgttataatt tgtaagcgtg gcaggtagag tcatggtcaa tgtattgccg cttacgctca
    10621 tgttttgttg gtaaggatag atggagaata cagccgtttc tccgcttggc ttgctgccgt
    10681 tgaaagtggc ggaagtttga ccagcaccgc ttgcatattc taattttgta ttgctataat
    10741 tactttctgc attactacag aacaacccta gggcatcggt atcttgccat agaatcttgt
    10801 attcatcgtt tacggtagta cgggtgtcgg tacctgcgcc ttcaaacgtt gcgttaacgg
    10861 tgatgtttcc tttccacccg ctgttttcaa attcctcttg gctgcaactg aatgcggtca
    10921 aggcagcagt tgccatgcag gcaacttgca taaggtttct taatttcatc ataatgaagt
    10981 cccccttagt tttctacggt taagatgtca ttgattaggt cttccaagtc gctgctggat
    11041 gccgaattgt agctatgggt agaggtgctg cccgaatagg agcgcgtaat gggatggtaa
    11101 ggttcgccgc ttgttgcaat gactccttca ttctccattt tgataacttc gatagacgga
    11161 gtgatgtatg cttctctacc gtctggtgtg ttctgtttca tatacacaaa ttatttaaag
    11221 gttaaacaat aaaaaaaacg tgagtaacta tgtttgtata tcctttattc aggccttcgc
    11281 attgcccttt ccctggatat acaacagtca ctcacgtcgt ttgtgtatat actatccccc
    11341 ctgatgggag aaaaccatat aaacatagac gtgagcatcc ttgttgttat cttcagggaa
    11401 attttcaaag ttgcgaagtt tgaataaaga agataatttc aataatgctc ttactaatat
    11461 gtaaataaac ccactacgct atagcggatt tgtgacaaag ataattgttt tttgtttaag
    11521 tgtatctatg tttctctatt ttttttggga aaggctcacg tctctttcat ttataggagt
    11581 taggagagtt atcacttcta actcccgata actccttcaa atatttagta actgtctgca
    11641 ttgtctttga ggatgttttt ctgaggagca tagcggctat gtggcgaata aagaggggaa
    11701 gacagaccga aaagaagctg aataaaatct ttttaagcaa aattaaaaca gagatttgat
    11761 atactttaaa cagaacaccc tgcaaactcc ggcttgctct gtccggcagt ttgcagggtg
    11821 gctgcttggt tttctcgcgt gtacgtagct ccttatgcca cgaacggaag tcgatgccat
    11881 agcaattttt cataataaga ctttccatat ttttgcaaat gtccgtactg cctttggctg
    11941 aaacaattta tataagtaat tgaagtttcg taagtgagta tgcctgctga taaatgggaa
    12001 tttatcgcac agagcgcgaa gcctgctctc ataacctatg gagagcacga gtgaaagctt
    12061 gtggattttt atctaaaaca taggtattcc tttactcttc tccctttgtt tgtctgctgt
    12121 ggcataggga atttatgacg cctaacggcc atgaacaacc ctgctttcga ccataaagca
    12181 atcgtttgac gaccgtaagc agagttgttc atggccgtta ggcgtcacta actccagagc
    12241 tattacagat gaagtacgta gcccgaacct attgcgcaca aggcgcaaac gtattataca
    12301 acggtgtaaa agacattaga gtgcattatt catagtcggc ctttgattcc cgataactcc
    12361 tactatgctc ctacagtcca actccatatc cgttgacttc acagtaagga caagcccgaa
    12421 aatgcaggaa aaccgaacct gccgattcat gtaatctgca tgcagtatta tgctagggga
    12481 tagcagctta ctgcaaaact caggcgtttc aggcaggtgg aagcaaattt tgcttccacc
    12541 ttttcaggtt gcttccatcg cagggcaaat gccgatggac agggggatgc aggaggtggg
    12601 tggaagtgtg gaagcaaagt gatggaaaat taatttggca ttcacacaat aataaccgta
    12661 tatttgtagc atggctgtct gcctcctctt aaattcagat aaagaggagg tagacaaatg
    12721 cttgctatga gaaacacata aatggttata accaagtgat gaaacaatta attgcatgtt
    12781 gcggactgga ttgcgaaaat tgcgccgccc gtatagccac tgtcaataat gacgatgagc
    12841 tgagagagaa aaccgccaaa gagtggagtg tgctgaacaa tacgccggaa attacggcgg
    12901 aaaccatcca ttgtatgggg tgccgtgcag acggggtgaa gtttacctat tgcagcgatt
    12961 attgtgctat ccgcaaatgt gtgtacgaaa aaggtttcaa tacttgtggc gactgtaagg
    13021 aactggatac ttgccaggtg gtaggtgcgg ttcttcagca tgcgcccggt gcaagggaaa
    13081 atctttatta accgtaaaat ctttgattaa ataaaatatt gcttatcttt gcagtatgac
    13141 aaagacattt aaatcggatt tggttttgta aacaatctgt gttccatgca cagattgtcc
    13201 cctttcgttt actttcggat aacttctttc gagagtgttt ttctattgtt ataattcaag
    13261 tttaatccgc atattatgct gaaggtgttg tgatactttc cgtatatgca aaatatagta
    13321 agaaaatgag taacgaaaat aaaactatcc acgatttcga atttaattta atctgtgact
    13381 ttttctccaa tatggaacgg caaggccctg gcagtcctga agtgacgttg aaggcattga
    13441 gctttgtaga cggtcttacc gatgaatccc ttattgccga tatcggttgt ggaacgggtg
    13501 gtcagacaat ggtattggct ggccatgttc cgggacagat taccggaatt gaccttttcc
    13561 ccggctttat tgacatcttc aaccgtaatg caaggcagtt gggcttgcag gacagagtaa
    13621 aaggaattgt cggttcaatg gatgccctcc ctttcggtga ggaggagctg gatatgattt
    13681 ggtgtgaagg tgctatctat aacatcggct ttgaacgtgg cttgaaggag tggcgtaaat
    13741 atctgaaacc gggagggtat attgccgtat ccgagagttc atggtttacg gacgaacgtc
    13801 ctgcggaaat caatgacttc tggatggacg cctattctga aatggataca cttcccaatc
    13861 aggtgaccaa gttgtacaag gcaggttatc ttcccgttgc tacattcatt ttgccggaga
    13921 attgctggac agagcattac tttgcttcaa aggttgcggc tcaggagatt ttccgtaaga
    13981 aatatgccgg taataaaatt gccgaagagt tcagcttact ccaaatgatt gaggatgaac
    14041 tgtacggcaa gtataaggaa ttttacggtt atgtgttctt tattgccaag aaggtaggct
    14101 gatgacggac ttctcttatt gaggaatgcg ggtattctca ggacagaata tccgcatttt
    14161 gggttttgag tagattttat tgttttgagg atgtacggaa cttctgagga ggtattcccg
    14221 tatgacgttt aaagaatttg ttgaagaagg ccgcattatt aaaacctaga ctcacggcta
    14281 tatcctttat cggagtgttg gcggtacaaa gttgtgcttt ggcatccatg atgatagtat
    14341 tgttgatgat ttccatggct gtatatcctg attccttttt gacaaggcgg caaagagctg
    14401 ccggtctcat attcattttc aatgcataat aggacacttg atgctcccgg acatagtctg
    14461 tgtgtaccaa tcggataaaa atgcggtatt ggttgaaatg cctgctgccc ggagtctctt
    14521 ttattctagg gcgttccgga cagagttcgg atataccttg taacagatag gtcagtagag
    14581 tttgcaatga aactagactt gaggggcttt ctgttctttg gtagaggtgt gacaaatagg
    14641 tcatgaactc ggcataaagc tggaagtccg ttctcgatag aggaaaaata tagtgtttgc
    14701 ctataatgtg aaacttatcc atcatgacct tgccggcccc tgaactctgg ataagttgtt
    14761 gggaaaatat gacgacatat atttcagcat cgtctgacgt gtgtagcaat tgtacgaagg
    14821 tctcgggagg aataactagg agggcgttag cttcaaccct gaattgagta tggtttatga
    14881 tagttttcag aactcctttg gtgcatagag cgaagatact ggccttggtg tggtatggct
    14941 tttccactag cggattcagt tcattggttg tgatatgatt gcaggcaatg aactcgtcat
    15001 ttatattgaa ttcggatata ttcatgttgg agattttaag acgcaaaaat gggggataat
    15061 aatgtataaa tgacagaggt aacagttaaa atcaatatta cgctcaactt atctctgtta
    15121 aataaggtaa agttgtgaat aatagaatat aagtaactaa tcaaaattaa gcagcataat
    15181 ggctaaagtt aatattcagt cg
//
