LOCUS       c00172_gnlPro..        10878 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KCAOGNOC_172.
ACCESSION   c00172_gnlPro..
VERSION     c00172_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 15:54:03
            Original ID  :: gnl|Prokka|KCAOGNOC_172
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10878
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10878
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:4517]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..4517
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..10878
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10878
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             2..256
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg172_1"
                     /sec_met_domain="ILVD_EDD (E-value: 5.4e-23, bitscore:
                     70.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="PEAAAGGAIGLVKDGDIIEINIPERTIHVKVTDEELAKRREAEEA
                     RGTKAFTPPFRQRTVSKALKAYAKMVASADKGGVRIVED"
     CDS             397..2094
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg172_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3e-51, bitscore:
                     162.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQL
                     KHILVRHEQGATHAAQGYARVSGKVGVTVVTSGPGATNTITGIADALMDSTPMVVIAGQ
                     VPSPLLGTDAFQEVDVIGITQPITKWAYQIRRPEEIAWAVSRAFYIASTGRPGPVVLDL
                     AKDAQVGLVDYEYQKVDYVRSYQPEPDIREERIEAAASLINNAKKPFCLVGQGVILGGA
                     EEELKEFLLKNDIPAGSTVLGLSALPSDFPLNKGMLGMHGNVGPNRKTNECDVLIAIGM
                     RFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERKR
                     PEWNAEFEPDEKEEYNKVIEKELYPTEGQLKMGEVVRKVSEATDNDAILVTDVGQNQMM
                     GVRYFKYKQTRSVVTSGGLGTMGFGLPAAIGAKLGAPDRTVCFFTGDGGIQMTIQELGT
                     IMQENLNVKIIVLNNNFLGMVRQWQELFFNERYSNTIMKNPDFVAIAKAFGIASRAVDK
                     REDLDEAIAEMLNHDGAYMLVANVETCGMVYPMVPAGGSVTNMILGDK"
     CDS             2107..2661
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg172_3"
                     /sec_met_domain="ALS_ss_C (E-value: 1e-18, bitscore: 56.7,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKQLYTVIIFSENTVGLLNQITVIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDTIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEDLIRKYNARILEMNEDCVVLEKSGHYDETQALFKELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLSAMEKKLQEKHV"
     CDS             2698..3429
                     /locus_tag="ctg172_4"
                     /transl_table=11
                     /translation="MEKNKVGEFHFVTESYLMDFRGRITIPMIGTYLLHAASCHAADRG
                     FGYNDMTERHTAWVLSRLAIEMTSYPAMSESVTLYTWVDEVGKLFTSRCFELVNGEGKT
                     FGFARSIWAAIDMETRRPTLLDVEGLSAYITDRPCPIEKPGKIAPVENNTSGEPYRVKY
                     SDLDVNGHLNSIKYMEHLLDLFDISLFREKEISRFEIAYQSEGKYGMELTLHNQEVSPG
                     KYNMAICNDGKAISRAAVTWI"
     CDS             3471..4517
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg172_5"
                     /sec_met_domain="IlvN (E-value: 1.1e-48, bitscore: 154.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.5e-44, bitscore: 140.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVMNFGGVDENVVTREEFPLEKAREVLKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRKGGKTWEKAVADGWVPGETLFDIEEACEKATIIQYLLSDAAQI
                     EVWPRIKKYLTPGKALYFSHGFGITYKERTNIIPPADVDVILVAPKGSGTSLRRMFLQG
                     RGLNSSYAIFQDATGKAWDRVIALGIGVGSGYLFETTFKKEVYSDLTGERGTLMGAIQG
                     LLLAQYETLRENGHEPSEAFNETVEELTQSLMPLFAENGMDWMYANCSTTAQRGALDWM
                     GPFHDATKPVFQKLYSEVACGNEAQRSIDTNSKPDYREGLEKELAALRESEMWRAGAVV
                     RKLRPENN"
     CDS             5019..8297
                     /locus_tag="ctg172_6"
                     /transl_table=11
                     /translation="MISVLLGAAGAIAANPTGPETMVVQQGNKVTGLVEDQMGPVAGAS
                     VVVKGTTIGMITDIDGKFTLDNVRRGAVIVISFVGLATQEITWNGQSILNVKLSDATQD
                     LDEVVVVAYGTAKKSTFTGSASVVKAEKLEKIMGSGFAEALQGMSAGVNVVNVQGNPGA
                     DARVEIRGIASMSGKADPLYIVDGMPYDGKLNQINPTDIESMTVLKDAAATSLYGSRAA
                     NGVVMITTKRGKSEKPRINFRGGWGTSDNAVKNPKKADPYQQLENTWYALYYDALLYDG
                     MNMQQAGDYASSQALTKQVKATKDSNGNLIYVTPFRHINENYVLHDGNGNPYMNPNLEY
                     VWDEDDWDVYKAIFSRKLRQDYSVDISGQANGGKTAYFFSGGYLDDQGYGNRQYYKRYS
                     FRTNLSTELFDWWKVAGSLSYSRHRQNLSGGASRAANFTTTLSSPWLRNEDNTGWVVSE
                     KTGERMYSYGKYTNNFFGAHILNNSGDYWDNPNDDSFDNNMGHILSAQVNTEFTLPFNL
                     KFRSALNIDDYWYRTMQYTSAVHGSGQTAPYGISILADGGYASRYNFNKRSTTWNNVLS
                     GEWMIGDHTISGLVGHEWYTWDSHYEQGWGEGIMELGKYELSNTTKNFGVSGGRDKYSL
                     LSFFGKVDYNFLNKYYLSASLREDGSSRFSSDHRWGTFWSTGGSWRISKEGFMEDLKWI
                     DNLSLRGSYGTTGNDKLIVRESNGKAGDEVLYGYQGTYESDDLYLKSGLKPSTYPTPDL
                     KWESNQQWNIGLDFSVFNRLSGTVEYYSRTSHDLLYYKELPLSAQVGSASGYNMNIGDL
                     RNSGIEITLNANILTTKDFRWDIDANMSTLKNEVTYLPTGPYTYSGTACTYKMEEGKSL
                     YEFIAPQYDGVNPETGVPGWLIRDGNGGWKRTEKQEEVTTDDFVYCGSAIPKVFGAITN
                     NFQFKGIDLSFMFYYSYGSKISDYTYKERIMNRPGVGVIQELVEDRWRQPGDTDVLIPR
                     WSYNQYGATVKYADNFVFDNHYWRLRNLTLGYTLPKSLTRKALVENLRVYVTGNNLLTF
                     GPAKKRYTDPETGIMGNSYNGNAETDNGIQGSRRLYMVGIQITL"
     CDS             8316..9905
                     /locus_tag="ctg172_7"
                     /transl_table=11
                     /translation="MKRFINISFLSLVFAGMALTGCNDDLTTSSYVKVNDEDVLGNVSQ
                     LEKVLTSAYKQLYFNTDKGDRVYAGLPGFQMYVDASGADVISHTNMGGDQVTAYQYSNS
                     KTQADGNASKIWSMCYNVINRANIILTNVDAAAGDETQKKHIKGQALAMRGIQYFHLIQ
                     NYQQTYAIAKSKRGVILRTSSDDESHKGFSTVEEVYTQIVSDLTTAKTLLADYNPDDMW
                     LINSKICSGILARVYLVMQNWDGAYNEAKIVYDQHSQLMTREQYRSGFDDMISGNYAEV
                     VWAMKYTADNNLGGSTQFNFWYNQDASYGEGYADGPIYSFLDYFVDEQFVKLFEEKEDR
                     YQFWKRTNNANTEINTKWAFDKYKHYGEDGGSVIQSATRPEVCLMRGAEMLLIMAEAAA
                     QKGNSGEALNLLNRLQVARNATPTTNAGGEALLEDIYVERRKELICEGQAGFYDLVRLQ
                     KRLVRIGESTTNPAGHYVWGMQYLNGYNALDPQPIGTLESNDYRFFCQIPQMEILNNDA
                     ISESDQNPWSGQ"
     CDS             10424..10555
                     /locus_tag="ctg172_8"
                     /transl_table=11
                     /translation="MSLRKIVSLSTDNSEHDISETVDANQSRMETSLPVTKQTAKSK"
     CDS             10574..10678
                     /locus_tag="ctg172_9"
                     /transl_table=11
                     /translation="MNIMSVNGLWRKQTYFLFVHSRKGKHTFINITDI"
ORIGIN
        1 tcccgaagct gctgccggcg gagcgattgg cttagtgaaa gacggcgata ttatcgaaat
       61 taatattccc gaaagaacca tacatgtaaa ggtgacagac gaagaactgg ccaaacgccg
      121 tgaagcggaa gaggcccgcg gaacaaaagc ctttacacct cctttccgcc aacgtacggt
      181 atcgaaagca ctgaaagcat atgcaaagat ggttgcttcg gccgataagg gcggtgtacg
      241 aatagtagaa gattaattag taacaaagag tattctttcc cctcttgaga ggggataagg
      301 ggtgtgttaa agttcagctc tattggatag cattaacaca ccccctaccc cctctcaaga
      361 ggggaaaggt taccatcaga caataaaaca acaaatatgg aacaaaagat aaccggttcg
      421 gaagctttgc tgaaagcgct gatcgctgaa ggagtagata ctatcttcgg ttatccgggt
      481 gggcaggcga taccaattta cgatagttta tacgattaca gagatcagtt aaaacatatt
      541 ctggtgcgcc acgaacaagg tgcaacacat gctgcacagg gatatgcccg tgtttccgga
      601 aaagtgggag taacggtggt tacttcgggt cccggggcaa ccaataccat cactggtatt
      661 gccgatgcgc tgatggacag tacaccgatg gtggtgattg ccggccaggt tccgtctccg
      721 ctgcttggaa cagatgcttt ccaggaagtt gatgtaattg gtatcacaca accgattacc
      781 aaatgggctt accagatacg ccgcccggaa gaaattgctt gggccgtttc ccgtgctttc
      841 tatatcgcat cgaccggtcg cccgggacct gtggtactgg atttggcgaa agatgcacag
      901 gtgggtttgg tagattatga gtatcagaaa gtggattatg ttcgtagtta ccagcctgaa
      961 ccggatatca gggaggaacg tatcgaggcg gctgcttcat tgataaataa tgccaaaaag
     1021 ccattctgtc tggtagggca gggggttatc ctaggaggag ctgaagaaga actgaaagaa
     1081 ttcttgttga aaaacgatat accagccggt tctaccgtat tgggcttgtc tgcattacct
     1141 tcggacttcc cattaaataa aggtatgttg gggatgcatg gaaatgtcgg accgaaccgc
     1201 aagactaacg aatgtgacgt gctgattgct atcggtatgc gtttcgatga tcgcgtaacc
     1261 ggcgacttga agacttatgc caagcaggca aagattatcc acctggatat cgacaattcg
     1321 gagatcggaa agaatgtgcc ggtcgacgtg aaagtgctgg gaaatgccaa gcatacgatt
     1381 ccgatgatta cggctttact ggaagaacgg aagcgtccgg aatggaatgc tgaattcgaa
     1441 ccggatgaaa aagaggaata taataaggta atagaaaaag aactctatcc taccgaaggc
     1501 caactgaaaa tgggcgaagt agtccgtaag gtttccgaag caaccgataa tgatgcgatt
     1561 ctggttacgg atgtaggtca gaaccagatg atgggtgttc gctatttcaa atataaacaa
     1621 acacgcagcg tagttacttc aggaggtttg ggaacgatgg gctttggcct tcccgccgcc
     1681 attggagcga agctgggagc gcctgaccgt acggtctgtt tctttaccgg cgacggtggt
     1741 atccagatga ctatccagga gttgggaact atcatgcagg aaaatctgaa tgtaaagatc
     1801 atcgttctta acaacaattt cctgggaatg gtacgccagt ggcaggagct gttcttcaac
     1861 gaacggtatt cgaataccat catgaagaat ccggattttg tagcgatagc caaggctttt
     1921 ggtattgctt cccgtgcggt agataaacgg gaagacttgg atgaggcgat tgctgaaatg
     1981 ttgaatcacg atggtgccta tatgttggtt gccaatgtgg aaacttgtgg tatggtatat
     2041 ccgatggttc cggccggagg aagcgtgaca aacatgattt tgggtgataa gtaaggagga
     2101 gaaactatga atacaaaaca attatatacc gttattatct tttcggaaaa cactgttggt
     2161 cttctgaatc agataactgt tatctttacg cgccggcaac tgaacattga gacgctttct
     2221 gtttctccct ctgctataaa gggaatacat aagtttacaa ttactacctt tgccgacgag
     2281 gatacgatcg acaaggtcgt aaaacagatc gacaagcgtg tggatatcct gaaagcttat
     2341 tataatacgg atgaagacct ggtttaccag gaaatcgctc tttataaact gagtaccgaa
     2401 ctctttatca agatggggac ggttgaggat ctgatccgta agtacaatgc ccgtatcctt
     2461 gaaatgaatg aggattgtgt ggtgttggaa aagagtggtc attatgatga gacacaggct
     2521 ttgtttaaag aattgagtga gacgatcggt gtcctgcaat ttatccgttc cggacgcgtt
     2581 gctataacga agagtaaggt agaacgtctg agcgacatgt tatctgcaat ggaaaagaag
     2641 ttgcaggaaa aacatgtctg agaataataa ggaaacattt tgtaaataaa gtaaattatg
     2701 gagaagaaca aagtaggaga atttcatttc gtaacagagt cttatctgat ggacttccgg
     2761 ggacgtatta caatccctat gatcggaact tatttgttgc atgctgcttc ttgccatgcc
     2821 gccgaccgtg gattcggata taacgatatg accgaaaggc ataccgcctg ggttctttcc
     2881 cgtctggcta tcgagatgac ttcttatcct gccatgtctg aatccgtaac tttatatacc
     2941 tgggtggatg aggtcggtaa gttgtttacc agccgttgct ttgaactggt gaacggcgaa
     3001 ggcaagacct ttggctttgc ccgctctatc tgggcggcta tcgatatgga aacccgccgc
     3061 ccgaccttgc tcgatgtgga gggcctgagt gcttatatca ccgaccgtcc ctgtccgatt
     3121 gaaaaaccgg gtaaaattgc tccggtggaa aacaacactt ccggcgaacc ttaccgtgtg
     3181 aagtacagtg acctggacgt aaacggccac ctgaacagta tcaaatacat ggaacacctg
     3241 ctcgacttgt tcgatatcag tctgttccga gaaaaagaga taagccgttt cgaaatagct
     3301 tatcagtccg aaggaaagta tgggatggag ctgactctcc ataaccagga agtatccccc
     3361 ggtaaatata atatggcaat ctgtaacgac ggcaaagcca tcagccgcgc tgccgttacc
     3421 tggatctgaa aaacaaatta ttttatatac attttaatag taaaaagaaa atggcagtaa
     3481 tgaattttgg cggcgttgac gaaaacgtag taacccgcga agaatttccg ttggaaaagg
     3541 caagagaagt attgaaagac gaaacaatcg ctgtaatagg ttacggcgta caaggtcctg
     3601 gccagagcct gaacctgcgc gacaacggtt ttaacgtaat tgtaggacaa cgtaaaggtg
     3661 gtaagacctg ggaaaaggcc gttgctgacg gttgggtacc gggcgaaaca ctgttcgata
     3721 tcgaagaagc atgcgaaaaa gcgactatca tccagtatct gctttcagat gctgctcaga
     3781 ttgaagtttg gccgcgcatc aaaaaatacc tgactccggg taaggctttg tatttctctc
     3841 acggattcgg catcacttac aaagaacgta caaacatcat ccctcctgct gatgtagacg
     3901 taatcctggt tgctccgaaa ggttcaggta cttcactgcg ccgtatgttc ttgcagggtc
     3961 gtggtctgaa ctcaagctac gcaatcttcc aggatgcaac aggcaaagca tgggatcgcg
     4021 tgattgcact gggtatcggt gttggttctg gttacttgtt tgaaacaaca ttcaagaaag
     4081 aagtttattc tgacctgacc ggcgaacgtg gtactttgat gggagctatc cagggattac
     4141 tgttggctca gtacgaaact ttgcgtgaaa acggtcacga accttctgaa gcattcaatg
     4201 aaacagtaga agaactgact cagtcattga tgccgttgtt cgcagaaaac ggtatggact
     4261 ggatgtatgc aaactgttca acaactgcac agcgtggtgc tttggactgg atgggcccgt
     4321 tccacgatgc tacaaaaccg gtgttccaga agttgtatag cgaagttgcc tgcggtaacg
     4381 aagcacagcg ttctatcgac acaaacagca agcctgacta tcgtgaaggt ctggaaaaag
     4441 aactggctgc tcttcgcgaa agtgaaatgt ggcgtgcagg tgctgttgtt cgtaaacttc
     4501 gtcctgaaaa caactaataa atggtgatac attaatagtt aaacattttg tgatataaaa
     4561 acggcaatcc ggcttttcgg gttgccgttt ttttatggtt tatgtaatgt gttaatggtt
     4621 aaaaaatgtt tttgattgca actgttattg atttttcatc ccaatatgta tgtcattgtt
     4681 tgaatgtgga ttttagataa aaaaatcaat taaatggtgg ttaaaatata tttattagag
     4741 caataaatat acataattat gcttgtatta aataatgata agttatattt gctgatggag
     4801 atactgtagt ttgtagagtg gaaatataga aggatgttgt gtgtaatgat cagtatatct
     4861 ttgttttagt taactttatt ttattgaaat gtatgccagt cacttttatc ttagaaaagt
     4921 gtaacctcta atgaaatgaa cgctattgtg attaatttta tttaattaaa gacttgaatt
     4981 tagctatgtg gaccaactca aaactaatta gatcactaat gatttctgta ttattaggtg
     5041 cggcaggtgc gattgctgcc aatcctacag gtccggaaac gatggtagta caacagggta
     5101 ataaggtaac cggcctggta gaggaccaaa tgggacctgt cgccggagct tctgttgtag
     5161 tgaaaggaac cactatcggt atgataaccg atatcgatgg aaagtttacg ctggataatg
     5221 ttcggcgggg agcggttatt gttatttcct ttgtcggcct ggccactcag gagatcactt
     5281 ggaacggaca atctatttta aatgtaaaat taagtgatgc gacacaggac ctggatgaag
     5341 tcgttgtcgt agcctatgga acggctaaga aatcaacctt caccggatcg gcctccgttg
     5401 taaaagctga aaaactcgaa aagatcatgg gctccggctt tgcggaagca ttgcagggga
     5461 tgagtgccgg tgtgaatgtt gtgaatgtac agggtaaccc cggagctgat gcccgtgtgg
     5521 agatccgtgg tattgcttcc atgtccggaa aggccgatcc gttatatatt gtggacggga
     5581 tgccttacga tggaaaactg aaccagatca atcctacgga catagaatcg atgacggtgc
     5641 tgaaggatgc ggcggccact tcgctttacg gttcgcgtgc agcaaacggc gtcgtaatga
     5701 ttacaaccaa gcggggtaaa tcagaaaaac cgcgtattaa cttccgcgga ggttggggta
     5761 cttcggataa tgctgtcaag aatccgaaaa aagccgatcc gtaccagcag ctggaaaata
     5821 cctggtatgc cttgtattat gatgcccttc tttatgacgg catgaatatg caacaggcgg
     5881 gcgattatgc ttcgtcacag gcattgacca aacaggtaaa ggctacaaaa gattcgaatg
     5941 gtaatctgat ttatgtcact ccgttcagac atatcaatga aaattacgta ttgcatgacg
     6001 gcaatgggaa tccttacatg aatcctaatc tggaatatgt ctgggatgaa gatgattggg
     6061 atgtctacaa agctatcttc tcccgtaaac tgcgccagga ttatagtgtg gatataagtg
     6121 gtcaggccaa tggtggaaaa acagcctatt tcttctccgg cggttatctg gacgaccagg
     6181 gatatggtaa ccggcagtat tataaacgtt attctttccg taccaacctg agtacagagt
     6241 tgttcgattg gtggaaagtg gccggtagcc tttcttattc gcgtcatcgc cagaaccttt
     6301 ccggtggtgc cagccgtgcg gctaacttta cgacgacttt gtcttcaccc tggttacgta
     6361 atgaagataa taccggttgg gtcgtttctg aaaaaacagg ggaacggatg tacagttacg
     6421 gtaaatatac caataacttc tttggtgccc atatcctgaa taactcgggt gattattggg
     6481 ataatccgaa cgatgacagt ttcgataaca atatggggca tatcctgtct gcccaggtaa
     6541 atacagagtt tactcttcct ttcaacctga aattccgttc ggctttgaat attgacgatt
     6601 actggtatcg taccatgcaa tatacttccg ccgtacatgg cagcggacag actgcacctt
     6661 atggtatttc tatactggca gacggtggtt atgccagccg ttataatttc aataaacgtt
     6721 ccaccacctg gaataatgta ttgtctggtg aatggatgat tggtgaccat acgatttcag
     6781 gtctggtcgg acatgagtgg tatacctggg actcccacta cgaacaaggt tggggtgaag
     6841 gtatcatgga actgggtaaa tatgaattat cgaataccac caagaacttc ggtgtttccg
     6901 gcggacgtga taaatactct ctgctttcgt tcttcggtaa agtcgattat aacttcttga
     6961 ataagtatta cttgtccgct tcgcttcgtg aggatggttc ttcccgtttc agttccgatc
     7021 atcgctgggg tacattctgg tcgacaggcg gttcgtggcg aatatcgaaa gaaggtttta
     7081 tggaagacct gaaatggatt gataaccttt cgttgcgtgg tagttacggt acgactggta
     7141 atgataagct gattgtgcgt gaatcgaatg gtaaggcagg ggatgaagtc ctttacggat
     7201 accagggtac ttatgaaagt gatgacctgt atctgaaatc cggtttaaaa ccatctacct
     7261 atccgacacc ggacttgaag tgggaaagta atcagcaatg gaatatcggt ttggatttct
     7321 ccgtattcaa ccgacttagc ggtacagtgg aatattattc ccgtacttcc catgatttgt
     7381 tgtattataa ggaactgcct ctgtctgccc aggttggtag tgcatctggg tataatatga
     7441 atatcggtga cctgcgtaat agcgggattg aaatcacatt gaatgcgaat atccttacaa
     7501 cgaaagattt cagatgggat atcgatgcca acatgagtac gctgaaaaat gaggtgactt
     7561 atttgcctac aggtccttac acttattctg gtaccgcctg tacctacaag atggaagaag
     7621 gcaagtccct gtatgaattt atcgctcccc agtacgatgg tgttaatccg gaaaccggag
     7681 tacccggctg gttgatccgc gatggtaacg gcggttggaa acgtacggaa aagcaggaag
     7741 aagtaacgac agacgatttt gtgtactgtg gctccgcgat tcccaaagtg ttcggtgcta
     7801 tcaccaataa cttccagttc aaagggatcg acctgtcgtt catgttctat tattcttatg
     7861 gttccaaaat atcggactat acatataaag aacgtatcat gaaccgtccg ggtgtcggtg
     7921 tgatacagga gttggttgag gacagatggc gtcagccggg cgatacggat gtgcttatcc
     7981 cacgttggtc gtacaaccag tatggcgcga cggtaaaata tgcagataac ttcgtgttcg
     8041 acaaccacta ctggcgtctg agaaacctga cattaggcta tacgctgcct aagagcctta
     8101 cccgcaaggc cctggtagaa aacctgcgtg tttatgtaac cggtaataac ctgttgactt
     8161 tcggtcctgc caaaaaacgc tacacagacc ccgaaacagg tataatgggt aacagttata
     8221 acggtaatgc tgaaaccgat aacggtattc agggttcgag aagactgtat atggtcggta
     8281 ttcaaatcac attgtaaacg taaaaaatga tatttatgaa acgatttata aatatatcct
     8341 tcctgtccct ggtttttgct ggtatggccc tgaccggatg taacgacgac ctgacaacca
     8401 gctcctatgt gaaagtaaac gatgaagatg tactggggaa tgtctcccag ttggaaaaag
     8461 tattgacttc agcctataag cagctgtatt ttaataccga taaaggcgac cgtgtgtatg
     8521 ctggtcttcc cggattccag atgtatgtcg atgcgagtgg tgccgacgtg atcagccata
     8581 ccaatatggg aggtgatcag gtaacagcat accagtattc caactcaaaa acacaggctg
     8641 acggaaatgc ctcaaaaatc tggtcgatgt gctataatgt gatcaaccgt gccaatatca
     8701 tcctgaccaa tgtggatgcc gctgccggtg atgagacaca gaagaaacat atcaaaggtc
     8761 aggcgctggc gatgcgtgga atccagtatt tccatctgat ccagaattac caacagacgt
     8821 atgcgatagc taaaagcaag cgtggggtga tcctgcgtac ctcttccgat gatgaatccc
     8881 ataaaggttt ttctaccgta gaggaagtct atacccagat tgtgtccgac ctgacgacgg
     8941 ctaaaacatt gcttgccgat tataatccgg acgatatgtg gctgatcaac tccaaaatat
     9001 gttcgggaat cctggcccgt gtttacctgg tgatgcagaa ctgggacggc gcttacaacg
     9061 aagccaagat cgtctacgac cagcacagcc agttgatgac ccgcgaacaa taccgttccg
     9121 gtttcgacga tatgatctcc ggcaattatg cggaagtggt atgggccatg aaatatacag
     9181 ccgataataa cctgggcggt agtacgcagt tcaatttctg gtataaccag gatgccagct
     9241 acggtgaggg ttatgccgac ggccctatct attcgttcct tgactacttc gtggatgagc
     9301 agtttgtgaa actgtttgaa gaaaaagaag accgttacca gttctggaaa cgtacgaaca
     9361 atgcgaatac ggaaatcaat acaaaatggg ctttcgacaa atacaagcat tatggtgaag
     9421 acggcggaag cgttattcaa agcgctaccc gtccagaagt ctgcctgatg cgcggagcag
     9481 aaatgctgct gatcatggcc gaagctgcag cccaaaaggg taattccggt gaggccctga
     9541 atctgctgaa ccgtttgcag gtggcacgta atgctacccc gacaaccaat gccggaggcg
     9601 aagctttgct ggaagacatc tatgtggaac gccgtaaaga gttgatctgt gaaggacaag
     9661 ccggttttta tgacctggtg cgcctgcaaa agagattggt tcgtatcggt gaatcaacta
     9721 ccaatcctgc cggacattac gtatggggca tgcagtatct gaacggatat aatgcgctcg
     9781 atccgcaacc gatagggacg ctggagtcga acgattaccg tttcttctgc caaatcccgc
     9841 aaatggaaat cctgaataat gatgcgatct ccgaatcaga tcagaatccg tggagcgggc
     9901 agtaagtttc atctgttgta aataaataaa agagaggaag gtgtttatta catgcctccc
     9961 tctcttttat ttgtaacatt tgatgttcac tgttttactt tttgtccttt agcacttcct
    10021 gtaacatggc caccttctcc tgctccgctt tcaataaacg ttcgtataat tcaacgactt
    10081 tttctaaggg ggtaaatgta ggattataat tctggcaatt agcattatct tgccaggtgc
    10141 cggaaaagat attaatggaa gtggcttcgc ctagttccgt aattgcttct tcgggtatat
    10201 ctaatgcttt ggcaatcttt tcgattactt ccggctccag attacttctt ttttcgtatg
    10261 tcgaaagggt tggtagaaaa taaatccggt ttatctctca taataaatat cggaaagagt
    10321 tgcctgataa tatttgtacc acagaaaaaa cacatcaaag gtcaggcgct ggcgatgcgt
    10381 ggaatccagt attttcacct gatccagaat taccagtaaa cgtatgtcat tgcgaaaaat
    10441 agtttctctt tcaaccgata atagtgaaca tgatatcagt gaaacggtcg atgcaaatca
    10501 gagtcgtatg gaaacttcac ttcctgtaac caaacagacg gcaaaatcaa aatgatataa
    10561 aaatgaatga tatatgaata ttatgagtgt aaatggcctt tggaggaaac agacttattt
    10621 tttatttgtt cattctagaa aagggaagca tacatttatt aacataacag atatctgata
    10681 tcgatttttt atctcgttta aacccaagaa aattttagtt taaacgggtt tcaatttcgt
    10741 ttaaactgag ataaatttct attgtagtgg agtttttatt cgtttagaga agaaaaacac
    10801 ctcaattagt gcttttaaaa aaaagaaaat catatgtttt tagacagttt ttatttccag
    10861 agcaaccgct ttttgatg
//
