LOCUS       c00054_gnlPro..        15519 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OBCJJJFM_54.
ACCESSION   c00054_gnlPro..
VERSION     c00054_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 16:28:56
            Original ID  :: gnl|Prokka|OBCJJJFM_54
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15519
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..249)
                     /locus_tag="ctg54_1"
                     /transl_table=11
                     /translation="VAAVNHKDTYKASAVFLIVMGMLYLIDKFIGFASHGLPWVMQKDN
                     LLLYAAVIFLWFKADKSVGIVLAGIWLILNISLVIALL"
     protocluster    1..15519
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2012:6656]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2013..6656
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15519
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15519
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(252..788)
                     /locus_tag="ctg54_2"
                     /transl_table=11
                     /translation="MEQFSDLIKNRRSMRKFTDQELTQEEVVALLKAALMAPSSKRSNC
                     WQFLVVDDKDMLEKLSHCKEMGAAFLADAAMAVVVMADPLASDVWIEDAAIASIMIQLQ
                     AEDLGLGSCWIQVRERFTATGMPSGEYVHTLLDIPLQLQVVSIIAVGHKGMERKPFNED
                     HLQWEKIHINKFGGK"
     CDS             834..1856
                     /locus_tag="ctg54_3"
                     /transl_table=11
                     /translation="MWIDKQKTINLQLEMPVRLSTYRKGNAIPPLPGTNIFHSTELFHV
                     FEMTRGYEPLLIVAYIGNRPVGKLLAVIRKSMRLFPPAIIKRCEIYGTGEYFDEEQNKE
                     DLFGEMLEHLTNEVLCKSFLIEFRNLENPLFGYKAFRKNNYFAINWLRVRNSLHSKVPY
                     ERLSMSRKRQINKALRNGAIMEVADNEKDIQDFSRMLKKAYSSQVRKHFPDIGFFRLLA
                     WQNPEKELAKVFLVKYKGKIIGGSICLFSKESAYLWFSGGMRKTYAFLYPGILAVWAPI
                     TYAHEKGYAHLEFMDAGLPFKKHGYRDFILRFGGKQSSTRRWFRFSWKWLNKLLCKFYI
                     "
     CDS             2013..2426
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_4"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1e-25, bitscore:
                     80.5, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVKTA
                     FLKVGDVKIELLEPTSPESTIAKFIEKNNGNGGMHHLAFAVEDGVANALAEAETTGIRL
                     IDKAPRKGAEGLQIAFLHPKSTLGVLTELCEKP"
     CDS             2529..4082
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_5"
                     /sec_met_domain="CT_Btheta (E-value: 8e-292, bitscore:
                     958.2, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRATARMGGGDKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKVMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLAMIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNEIIPDSPN
                     KPYDMYEVISAIVDNGEFLEVQPHYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAAFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             4110..5039
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_6"
                     /sec_met_domain="OAD_gamma (E-value: 2.2e-15, bitscore:
                     47.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLNIGIFLSLLLMVGLCSCGEQKSNTKLVLNEVLIENESNFQD
                     DYGVHSAWIEIFNRSFGSADLAGCLLKVSSQPGDTATYFIPKGDVLTLIKPRQHALFWA
                     DGEPNRGTFHTNFTLNAATNNWIGLYDSGKKLLDQIIVPAGTLQANQSYARVSDAANEW
                     EVKGSSADKYVTPSTNNKTINSNAKMEKFEEHDSVGIGMSISAMSVVFVGLLLLFIAFK
                     VIGRISVNLSKRNAMKVKGITDKQEAKEKKLGEAPGEVFAAIAMAMHEMQSDVHDVEET
                     VLTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             5063..5494
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.7; E-value:
                     1.8e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_7"
                     /sec_met_domain="Biotin_lipoyl (E-value: 5.4e-21, bitscore:
                     64.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNIYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKAV
                     MKPVVRPASTSPAPAPTTVVKPAATSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVSKGESVLEGTDLVIIE"
     CDS             5496..6656
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_8"
                     /sec_met_domain="OAD_beta (E-value: 2.8e-153, bitscore:
                     500.2, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFINFLGNNLADFWTYTGFANATVGHIVMILIGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALAMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDTITILLGLTVGAS
                     TQASEFLTIDSILIFALGALSFIIATASGVIFVKIFNLVLGKDNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             6831..7079
                     /locus_tag="ctg54_9"
                     /transl_table=11
                     /translation="MEKKTVKYHIPQHGIYMYARTNSGKTELIVLNSTNAEQVVANNHY
                     RIMTNDSKSGKELISGKKIDLTKNMTVGARQSLIIEL"
     CDS             complement(7171..7929)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg54_10"
                     /sec_met_domain="adh_short (E-value: 1.5e-56, bitscore:
                     181.3, seeds: 44, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKIVFITGASSGIGAGCARKFASQGASLILNARNVNKLSALKEE
                     LEKQYGTEIYLLPFDVRDRKAATSALESLPKEWQSIDILVNNAGLVIGTDKEQEGSLDE
                     WDIVIDTNVKALLAMTRLIVPGMVERKRGHIINIGSIAGDAAYPGGSVYCATKAAVKAL
                     SDGLRIDLVDTPLRVTNIKPGLVETNFSVIRFRGDKEKADNVYKGIRPLTGDDIAETVY
                     FAASVPEYMQIAEMLVMPTYQATGTIVSRK"
     CDS             complement(7934..8752)
                     /locus_tag="ctg54_11"
                     /transl_table=11
                     /translation="MKKKYWAFLIGSWCLSVGMQAAKVDTLSVHSDAMNKEVQVITICP
                     DKAMAGEKCPVLYLLHGYGGNAGTWLGIKPELPQIADKEGIIFVCPDGKNSWYWDSPLN
                     KEYRYETFVSKELVNYIDKNFTTKVERGGRAITGLSMGGHGSLWLSIRHKDVFGGGGSM
                     SGGLDIRPFPNNWEMKKQLGEEASNKQRWDEHTVINQLDKIKNGDLAVIIDCGCDDFFL
                     EVNKAVHEKLLKKKINHDFIIRPGGHTGRYWNNAIDYQILFFSKFFNKSK"
     CDS             8850..10559
                     /locus_tag="ctg54_12"
                     /transl_table=11
                     /translation="MKKIKLESVFNEFTLMGIAVSGAFYLGEYWEGIAVILFYLIGEWF
                     QHKAVHKARSNIKALLDVRPETATVVYNNTYKITAPEKVQPGETIEVKVGEKVPLDGFL
                     LEDSASFNTAALTGESVPRTLYKQEEVLAGMIASDKVVRIKVNKPYDQSTLARILTLVQ
                     DAAERKAPAELFIRRFARIYTPIVTGLAILVVILPYLYSLIKPEFIFVFDDWFYRALVF
                     LVISCPCALVVSIPLGYFGGIGAASHKGILFKGGNYLDAITQINTVVFDKTGTLTQGVF
                     SVQAISAAEGVSQKELLQLIASIESFSNHPIAKAIVKYAEEQSISLNSSLRITEFAGYG
                     IKAVTNGKEVYVGNTRLLSKYGISFPYEISNMTETIVLCAMENKYLGYLSLADTPKPDA
                     VQAIRELKDLNINNIQILSGDKQTIVSNLAEKIGVTHAFGDLLPEGKVAHLEQLKANFE
                     NRVAFVGDGINDTPVLALSDVGIAMGGLGCDAAIETADVVIQTDQPSKVAEAIKIGKQT
                     HRIVWQNISMAFGVKLLVLLLGAGGTATMWEAIFADVGVALLAIFNAMRIQK"
     CDS             10582..11007
                     /locus_tag="ctg54_13"
                     /transl_table=11
                     /translation="MNETIYLKKLEQREIKPTAIRLLILKTMMQHKEAFSLLDLENELD
                     TVDKSTIYRTITLFLAHHLVHGIDDGTGSLKYAVCSNDCNCEVDDLHTHFYCENCHRTF
                     CMKSIHVPIVTLPPGFTVQSINYVLKGLCSECSHQHV"
     CDS             complement(11181..12332)
                     /locus_tag="ctg54_14"
                     /transl_table=11
                     /translation="MEKISSAAFTDTKPHYDLLDGLRGVAALMVIWYHVFEGFAFASAG
                     NIETLNHGYLAVDFFFILSGFVIGYAYDDRWGKNFTMKDFFKRRLIRLHPMVIMGAVLG
                     AITFCIQGCVQWDGTHVAISMIMLSLLCTIFFIPAMPGVGYEVRGNGEMFPLNGPCWSL
                     FFEYIGNILYALFIRRLSNKALAVLVVLLGMALASFAVFNVSGYGNMGVGWTLDGVNFL
                     GGTLRMLFPFSLGMLMSRNFKPMKVNGAFWICTIILIALFSVPYLEGLEPICMNGIYEA
                     FCVIAVFPFLVWLGASGTTTDKQSTKICKFLGDISYPVYVVHYPLMYLFYAWLIENKLY
                     TLGETWYVAVGVFVLSVILACLCLKLYDEPVRKWLSKKFLAPK"
     CDS             complement(12450..13013)
                     /locus_tag="ctg54_15"
                     /transl_table=11
                     /translation="MTNIIDNMLSLCPVSEDTIQELKKCMILCRFPKKYQLIKENTFCK
                     SAYFIEKGMTRSFWLVNGEEITTSFSWEGGIVFSMDELYYNKPSEEFVETLEDVVVYKI
                     SLVDLTKLFQTNIELANWGRIIHQNEYRRLHRSHKERLTLPAKERYEEFKQQFPQICQR
                     VKLRYIASYLGITLPTLSRLRAKK"
     CDS             complement(12994..13176)
                     /locus_tag="ctg54_16"
                     /transl_table=11
                     /translation="MDILVWGGLGNSDYLEKMMSFSNIYLYFWLKRKQGISRVYIWCFF
                     ICILNGLRFYDKHYR"
     CDS             13546..13989
                     /locus_tag="ctg54_17"
                     /transl_table=11
                     /translation="MKKIITLLLILLFTTKSTFSQSPNNIEKFTVVCVNDKDSILNKIK
                     MSTPQFYNIGKGKRIEIKVCNEDSIQIRRVRCLLYYSNSGKKECIGKIWISPLIGYETC
                     YFCMNVDIPLTKDEWHKLTFRIKRGKNYKDYKFLKQQVQEENI"
     CDS             14148..14591
                     /locus_tag="ctg54_18"
                     /transl_table=11
                     /translation="MSYIQNNLQAGEEIKYKADIHWYIFAYPVILLLLSVFFSSAQTGF
                     FHYVSLFLLLSGLFQLIKRILLKMGTEYVVTNKKVILKSGILSRDALELVLNKCEGIRI
                     NQSLMGRMLGFGSIVVTTGGVTNKFDFITNPIKFRNEINAQIQ"
     CDS             14744..14893
                     /locus_tag="ctg54_19"
                     /transl_table=11
                     /translation="MFIENPYQWGVSYDYALPLSENTLLHIHSHGAIHTYKLMRMYVKR
                     FSPE"
ORIGIN
        1 caacaaagct atcaccaaac tgatattcaa tatcagccat atacccgcca atacaattcc
       61 tactgactta tcggccttga accaaaggaa aataacagct gcatacagta acagattgtc
      121 tttctgcata acccatggca acccgtgtga ggcaaatcct ataaacttat cgatcagata
      181 aagcataccc atcacaatga gaaacaccgc agaagcttta tacgtatcct tatgattgac
      241 agcagccacg tttacttgcc tccaaattta ttgatgtgaa ttttctccca ttgtaaatgg
      301 tcctcattaa aaggcttgcg ttccatgccc ttatgtccta ccgctataat ggaaaccacc
      361 tgcaactgca acggaatatc aagcagcgta tgcacgtatt cacccgaggg catcccggta
      421 gcggtaaaac gttcacgcac ctgtatccaa caacttccca accccaaatc ttctgcctgc
      481 aactggatca ttatggaagc aattgccgca tcttcaatcc aaacatcact agccaacgga
      541 tcagccatca caactacagc catagcagca tccgctagaa aagctgcccc catctcctta
      601 caatgggaaa gtttttccag catatcctta tcatctacca caagaaactg ccagcaattg
      661 ctacgtttag aagacggagc catcaaagca gccttcaaca aagcaaccac ctcttcctgt
      721 gtcaactctt gatccgtgaa cttacgcata ctgcgtctgt tctttattaa gtcactaaat
      781 tgttccataa tatactcagt taatttattt ttctgcacaa atatacaact agaatgtgga
      841 ttgataaaca aaaaacaata aatttgcaat tagagatgcc tgtcagatta agtacatatc
      901 gcaaaggaaa tgccattccc cctctgcctg gaacaaacat tttccattct accgagttgt
      961 ttcatgtctt tgaaatgact cggggatacg aacctctgct tatcgtagcc tatataggaa
     1021 accgtcctgt aggcaaactg ctggctgtca tccggaagag tatgcgcttg ttcccccccg
     1081 caatcatcaa acgatgcgag atttatggca caggcgagta ttttgatgaa gaacagaata
     1141 aggaagacct gttcggggaa atgttggaac atctcaccaa cgaagtatta tgcaaatcgt
     1201 tcctcatcga gttccgcaac ttggaaaatc cgctattcgg atacaaagct ttcagaaaga
     1261 acaactattt cgccattaat tggctaagag tacgtaactc actgcacagt aaagtccctt
     1321 acgaacggct gagcatgtct cgcaaaagac aaataaacaa agcgttgaga aacggtgcca
     1381 tcatggaagt agccgacaat gagaaagata ttcaagattt ctcacgaatg ttgaaaaaag
     1441 cctattcctc acaggtaaga aaacatttcc cggacatcgg ctttttccgg ctattagcat
     1501 ggcaaaaccc agaaaaagaa ttagccaaag tgtttcttgt gaaatataaa ggcaaaatca
     1561 taggtggttc tatctgtctt ttctcaaaag aaagtgctta tctgtggttc tcaggaggta
     1621 tgcggaaaac ctatgctttt ctttaccccg gtattctagc cgtatgggca cctattacct
     1681 atgctcacga aaaaggatat gcacatttgg aattcatgga tgcaggatta ccgttcaaaa
     1741 agcacggtta cagggacttt atactccgct ttggcggcaa gcagagcagt acacgccgct
     1801 ggttccgctt cagttggaag tggctgaaca aactcttgtg caaattctat atttaattca
     1861 tttttgtctt tttgtctaaa gtgttgtgaa gcatctcgca aataagaaat aaaattgaag
     1921 aaatatttct ttatttaact cgaaattact ttctttgtgc agttttatct gaaaacttga
     1981 gtataaaacc aaactattaa aattataaga tcatgaaaat ctcacacatt gaacacctgg
     2041 gcattgccgt aaagagcatt gaagaggccc tgccgtatta tgaaaacgta ttaggtctga
     2101 aatgctacaa tatcgaaaca gtagaggatc agaaagttaa aaccgctttt ctgaaagtag
     2161 gtgatgttaa aatagaactg ctggaaccta caagccccga aagcactatc gcaaagttca
     2221 ttgaaaaaaa taatggcaac ggtggtatgc atcatttggc ttttgcagtg gaagatggtg
     2281 tggcaaatgc gttagccgaa gcggaaacca ctggcatccg tctcattgac aaagctccgc
     2341 gtaaaggtgc tgaaggtttg caaattgctt ttttacatcc caaatcaact ttgggcgtcc
     2401 tgactgagct ttgcgaaaaa ccataaaaca cgagatctga ctattcacga ttgaaatcag
     2461 tgtatttagt ctggttcaag cgtaaataga aatatttttt aatcgtaaat tgtaaaatca
     2521 taagtaaaat gagcaatcaa cttgaaaaaa taaaagagct tatcgaacgc cgggctacag
     2581 cacgcatggg tggaggtgat aaagcaattg caaaacagca tgaaaaagga aaatatacag
     2641 cccgcgaacg catagccatg ttgctggatg aaggcagttt cgaagaaatg gatatgtttg
     2701 tggaacacag atgcaccaat tttggcatgg agaaaaaaca ttatccgggc gacggtgtag
     2761 taacaggttg tggtaccata gaaggacgtt tagtttacat ctttgcacag gatttcactg
     2821 tttctgccgg ttctctgtca gaaacaatgt ctctgaaaat ctgcaaagta atggatcaag
     2881 ccatgaaaat gggtgctccc tgtatcggta tcaatgactc gggtggcgca cgtattcaag
     2941 aaggtatcaa tgcgctggcc ggttatgctg aaattttcca acgcaatatt cttgcttcag
     3001 gtgttattcc acagatttca ggtattttcg gtccttgtgc aggcggagct gtttactctc
     3061 ctgcgctgac agacttcaca ttgatgatgg aaggcacatc atacatgttc cttaccggac
     3121 cgaaagtggt aaagactgtt acaggtgaag atgtaagcca agaaaactta ggtggtgcaa
     3181 gcgttcattc taccaaatcc ggtgttactc attttactgc caagacggaa gaagaagggt
     3241 tagccatgat ccgcaaattg ttaagctata ttcctcaaaa taatctggaa gaagctccct
     3301 atgtagactg taccgatcct atcgaccgtc tggaagactc tttgaacgaa attatccccg
     3361 acagccccaa caaaccatac gatatgtatg aggtgatcag cgccatcgta gataatggtg
     3421 agtttttgga agtccaacct cactacgcta aaaatatcat cattggtttc gcacgtttca
     3481 acggacaatc tgtaggtatt gttgcaaacc agccaaaata tctggcgggt gtacttgaca
     3541 gcaatgcgtc acgtaaaggt gcgcgttttg tacgtttctg cgacgctttc aatatacctc
     3601 ttgtttcatt ggtagatgtt ccgggattcc ttccaggcac aggacaagaa tacaacggcg
     3661 taatcctcca cggcgccaag ttgctgtatg cttacggcga agcgactgta cccaaagtaa
     3721 caattaccct gcgtaaatca tacggcggat ctcacattgt aatgagctgt aaacaacttc
     3781 gcggtgatat gaattatgca tggcctactg ccgaaatcgc cgttatgggt ggtgcaggtg
     3841 cagtagaagt attatacgcc cgcgaagcca aagaacagga aaatcctgcc gcattcctag
     3901 ccgaaaaaga agctgaatac accaagctgt tcgccaatcc ttacaatgct gccaaatatg
     3961 gctatattga tgatgtgatt gaaccgcgta atacccgttt ccgcatcatc cgtgcattgc
     4021 aacagttgca aactaagaaa ttaaccaatc cggctaagaa gcatggtaat attcctcttt
     4081 aattaaaaat taaaaattga gaattgaaca tgaagaaatt aaatatagga atattccttt
     4141 ctttgctgct gatggtgggt ttatgttctt gtggagaaca gaaatcaaac accaagctgg
     4201 tactgaatga agtgctgatt gaaaatgaaa gcaatttcca agatgactac ggagtacaca
     4261 gcgcatggat tgaaatattc aatagatcat ttggtagcgc agaccttgcc ggttgtttac
     4321 tgaaggtgag cagccagcct ggagatactg ctacttattt tatccctaaa ggtgatgtat
     4381 tgactttgat caaacctcgc cagcacgctt tgttctgggc agatggtgaa cctaatcgtg
     4441 gtactttcca caccaacttc accctgaatg ccgcaacgaa caattggatc ggcttgtatg
     4501 attcaggcaa gaaattattg gatcagatta tagttcctgc aggtacatta caggcaaacc
     4561 aatcatacgc acgtgtcagc gacgctgcaa atgaatggga agtaaaaggt tctagtgcag
     4621 acaagtatgt aactcctagc actaacaaca agactatcaa cagcaacgct aagatggaaa
     4681 agtttgaaga acatgacagt gtgggtattg gtatgtccat atcagctatg agtgtcgtat
     4741 tcgtaggctt gctccttctg tttattgctt tcaaagttat aggccgtatt tctgtcaacc
     4801 tgagcaagcg caatgccatg aaggtaaaag gtattaccga caaacaagaa gccaaagaaa
     4861 agaaactggg tgaagctcca ggcgaagtat tcgccgcaat tgccatggct atgcacgaaa
     4921 tgcaaagcga tgtacacgat gtagaagaaa ctgttcttac cattactcgt gtaaaacgta
     4981 gctattcacc gtggagttct aagatttata ccttgcgtga aactccccac aaaaagtaag
     5041 tcaccaataa aaagataaaa cgatgaaaga atataaatat aagattaacg gtaacatata
     5101 taaggttgcc attggagata tagaagataa tatcgctcat gttgaagtaa acggcactcc
     5161 ttacaaagta gaaatggaaa aagccccgaa agctgtaatg aaaccggtag ttcgtcctgc
     5221 atcaaccagc cctgctccgg ctccaactac agtagtaaag cctgctgcaa cttctacagg
     5281 aaaatcgggc gttaaatctc cgttgccagg tgtaatcctt gatattaagg taaatgttgg
     5341 tgataccgta aaaaaggggc aaaccatcat tatccttgaa gctatgaaga tggagaataa
     5401 catcaacgca gacaaagacg gcaagatcac cgcaatcaat gtaagtaaag gagaatccgt
     5461 tctcgaaggt actgaccttg taattattga ataatatggg agaatttatc aactttttag
     5521 ggaataacct agctgacttt tggacatata cgggttttgc caatgctact gttggtcata
     5581 tcgtaatgat cctgataggt ttattcttca tataccttgc cgtggccaag gaatttgagc
     5641 cgatgttgct cattcctatc ggttttggta tcttgatcgg taatattcct ttcaacatgg
     5701 aagccggact gaaagtcggc atctatgagg aaggttctgt tcttaatatt ttatatcaag
     5761 gagttacctc cggatggtat ccaccactta tctttttagg tatcggtgca atgacggatt
     5821 tctcggcatt gatttcaaat cctaaactga tgttgattgg tgctgccgca cagtttggta
     5881 ttttcggtgc atacatgatt gcattggcaa tgggctttga tccgatgcag gctggtgcta
     5941 tcggcatcat cggtggtgcg gacggtccga cagcaatctt cctttcatcc aaactggcgc
     6001 ctaacctgat gggagctatt gcggtatcag cctattcata catggcattg gtaccggtta
     6061 tccagccgcc tatcatgcgt ctgctcacta ccaagcacga acgtttgatc cgtatgaaac
     6121 caccacgcgt cgtttctcat acagaaaaag taatgttccc tatcattggt ttgttactta
     6181 cttgttttct ggttccgtcg ggtctgcctc tattgggtat gcttttcttt ggtaacttat
     6241 tgaaagaaag cggtgtaacc cgtcgcttag cagaaactgc ccgcggtccg ctgattgata
     6301 ccattaccat cttattagga ttgacagtag gtgcttccac gcaagcttca gagttcctta
     6361 ccattgattc gatcttgatt ttcgcgctgg gtgcattgtc attcatcatt gctactgctt
     6421 ctggagttat cttcgtgaag atattcaact tggtattagg taaggataac aaaatcaacc
     6481 cgcttatcgg taatgccggt gtatctgctg ttcccgactc ggcacgtatc tctcaggtta
     6541 ttggtctgga atatgatcct accaactact tgttgatgca tgctatgggt cccaacgtag
     6601 ctggtgtaat cggttctgcc gtagcagccg gtattttact tggattcttg atgtaattca
     6661 ttgaacaaca acaaataaaa tcctcttcaa ctaatatgtg gaagaggatt ttttattgat
     6721 atagattaag aaatgaatga tttattatga attttgaatg attagttata taagatatgc
     6781 tgaaaaacat ataaatttgt cgccgtaaaa ccaaactaaa ttaaacgaag atggaaaaga
     6841 aaacagttaa gtaccatatt ccccaacacg gaatatatat gtacgcacgt actaattctg
     6901 ggaaaactga actcattgtc ctaaacagca ccaatgccga acaagtggtg gctaataacc
     6961 actaccgcat aatgacaaat gactcaaaaa gcggtaaaga acttatcagt ggcaaaaaaa
     7021 ttgaccttac caaaaatatg acagtcggtg cacgtcaatc attgattatt gaattataat
     7081 tgttttttaa ggtaagaagg taaaatgaga aggtaagaat aaaggtggct ttataaaggg
     7141 tcgcctttat ttatatctct tctacctctt ttatttgcgt gaaacaattg tccctgtagc
     7201 ttgataagta ggcataacca acatttctgc aatctgcata tattctggta cagaagcagc
     7261 aaaataaaca gtttccgcaa tatcatctcc cgtcaatgga cgaatacctt tatatacatt
     7321 atccgccttt tccttatctc ctcggaaacg aataactgaa aaatttgttt ctaccaaccc
     7381 cggtttaata ttagtcactc tcaatggagt atcaactaaa tctatacgca gtccatccga
     7441 taaagctttc acagcggcct ttgtagcaca atacacacta cctcccggat aagcagcatc
     7501 tccggcaata gaaccaatat taataatatg tcctcgttta cgttccacca ttcccggtac
     7561 aatcaggcgt gtcattgcca gcaaagcctt aacattagta tctatgacaa tatcccactc
     7621 atccagacta ccttcctgtt ctttatccgt accgataacc aacccagcat tattcaccag
     7681 tatatcaatg gattgccatt ccttgggtaa tgattccaaa gcagacgttg ccgccttacg
     7741 gtcgcgcacg tcaaaaggaa gcaaatatat ttccgtacca tattgctttt ctaattcttc
     7801 tttcaatgca ctcagtttat ttacgttacg agcatttaaa atcaaacttg ctccctgtga
     7861 agcaaacttg cgagcgcatc cggcaccgat accgctggaa gctcctgtaa taaaaacaat
     7921 tttatccatt ttattatttc gatttattaa agaacttact gaaaaatagt atttgatagt
     7981 ctatggcatt attccaatac ctgcctgtat gcccgcccgg acggatgata aagtcatgat
     8041 ttattttctt cttcaacagt ttttcgtgta cagccttatt cacttccaga aagaaatcat
     8101 cacaaccgca atctattata acagccagat caccattttt tatcttatcc aactgattaa
     8161 ttaccgtatg ttcgtcccat ctctgcttgt tgctcgcttc ttcgcctaat tgcttcttca
     8221 tctcccaatt attgggaaac ggacggatat ctaaacctcc gctcatacta cctcctcctc
     8281 caaagacatc tttatgacgg atggacaacc ataaacttcc atgaccaccc atacttaacc
     8341 cggtgatagc acgtccccct ctctccactt tcgtagtaaa attcttatca atatagttca
     8401 ccaattcttt tgatacgaat gtttcataac ggtactcctt attcaaaggg ctgtcccaat
     8461 accaactgtt cttcccgtcc ggacaaacaa aaatgattcc ttccttgtca gctatttgag
     8521 gtaattccgg ttttataccg agccacgttc ccgcattgcc tccatatccg tgaagcagat
     8581 aaagtacggg acatttttca cctgccatgg ctttatccgg acagatggta attacctgaa
     8641 cctccttatt cattgcgtca ctatgtaccg acaaagtatc cactttggcc gcctgcattc
     8701 ccacagacaa acaccagctt cctatcaaaa aagcccaata tttttttttc atgtatataa
     8761 aaaattaccc gatgtaaaag tacaatataa tttgcaattt agttgcatct tctttccact
     8821 atctttgttg ccataaataa aaagaaacaa tgaaaaaaat aaaattagaa tcagttttca
     8881 atgaattcac tttaatgggg atagctgtat caggagcatt ctatctagga gaatactggg
     8941 aaggtattgc cgttattctg ttctatctca taggtgaatg gttccaacac aaagctgtac
     9001 acaaagcacg cagcaacatc aaagcattat tggatgtacg tcccgaaaca gccactgtag
     9061 tatataataa cacatataaa ataacagcac cggaaaaagt acagccagga gaaaccattg
     9121 aagtaaaagt tggagaaaaa gtacctctag acggattttt actggaagat tccgcttcat
     9181 ttaatacggc cgccctaacc ggagaaagtg ttccccggac tctatataaa caagaagaag
     9241 ttttagcagg aatgatcgct tcagataaag tggtacggat caaagtaaac aaaccgtatg
     9301 atcaaagtac gttagcacgt atcctcactt tagtacaaga tgcagcagaa agaaaagccc
     9361 ctgccgaatt atttatccgc cgttttgcac gaatttatac accgatagtg acaggactgg
     9421 cgatactagt tgtcatactc ccctatttat actctctgat aaaacctgaa ttcatttttg
     9481 tttttgatga ttggttctat cgggctttag tattcctagt catatcatgt ccttgcgcat
     9541 tagtggtcag cattccatta ggatactttg gaggtattgg tgccgcatct cacaaaggga
     9601 ttcttttcaa agggggtaat tatctagatg ccataaccca aataaacacc gtagtattcg
     9661 ataaaaccgg aacactcacc caaggtgtat tcagtgttca ggcaatatcg gcagccgaag
     9721 gtgtttcgca aaaggaactg cttcaactta tcgcctctat agagagtttc agcaatcatc
     9781 ctatcgcaaa agccattgtc aaatatgcgg aagaacaaag tatatctctt aactcgtcac
     9841 tgagaatcac tgaatttgcc ggatatggaa taaaagccgt aacaaacggt aaagaagtat
     9901 atgtaggaaa tacacggtta ttatcaaaat acggcatctc ttttccctat gaaatcagca
     9961 acatgacaga aacaatcgtg ctatgtgcaa tggaaaacaa atatttggga tatctttcat
    10021 tggcggatac cccaaaacct gatgctgtac aagccatccg cgagctgaaa gacttaaata
    10081 ttaataatat tcaaatatta tcgggagata aacagacaat tgtttctaat ttagccgaaa
    10141 agataggtgt cacacatgct ttcggcgatt tactacccga aggtaaagta gcacatttag
    10201 aacaattaaa agcaaatttt gaaaatcgtg tagcttttgt aggagacggt atcaatgata
    10261 ctcccgtact ggcactcagc gatgttggga ttgccatggg tggtctaggc tgtgacgctg
    10321 ctatagagac tgcggatgta gtgatacaaa cagaccaacc cagtaaagta gcggaagcta
    10381 taaaaatagg aaaacagacc catcgcattg tatggcaaaa tatatcgatg gcattcggag
    10441 tgaaattgtt agtattgcta ttaggagccg gcggaacggc cactatgtgg gaagctatat
    10501 ttgcagatgt aggcgtagct ttactcgcca tttttaatgc aatgagaata cagaaatgaa
    10561 aagaataaaa tgatttgacc tatgaatgaa acaatctatt taaaaaaatt ggaacagcgg
    10621 gaaatcaaac cgacagccat acgtctgctt attctaaaaa ccatgatgca gcacaaagaa
    10681 gcattttcac tgttggattt ggaaaacgaa ttggatacgg tagacaaatc aaccatctac
    10741 cgcaccataa cccttttttt agcccatcat ttggttcatg gcattgatga cggcacagga
    10801 tcgttaaaat atgccgtgtg cagcaatgat tgcaattgtg aggtagacga tctccacact
    10861 cacttttatt gtgagaactg tcatcgcacg ttttgtatga aaagtatcca cgtgcccatc
    10921 gtgacactac ctcccggatt caccgtacaa agtatcaatt atgtcctgaa aggtctatgc
    10981 tcggaatgct ctcatcaaca tgtgtgacta ttgccaaaaa aggaaatcaa tcctaaagcc
    11041 cattttgaaa taatcgaatg caggcatccg aatttacaga tcggatgcca ttcatctaat
    11101 tgtcagttat tcaaagctgt aatatcttct tgtatagtgt ccgacctttt aatgaacatc
    11161 catcaagaaa tgcagtattt ttatttggga gcaagaaact tcttactcag ccattttctt
    11221 acgggctcat catacagttt cagacacagg caagccaaaa tgacactcaa aacaaaaaca
    11281 cccacagcta cataccaagt ttctcccaat gtataaagtt tattctcaat caaccatgcg
    11341 tagaacaaat acatcaacgg ataatgtact acataaaccg gataggatat atctcccaag
    11401 aacttgcata tctttgtaga ctgcttatcc gtagtagtac ccgacgcccc cagccacaca
    11461 agaaaaggaa aaaccgcaat tacacaaaaa gcttcataaa taccattcat gcaaatcggc
    11521 tccaatcctt ccagataagg aaccgagaac agcgcaatca gtataatagt acatatccaa
    11581 aatgccccat tcaccttcat aggcttaaag ttacgcgaca tcaacatacc caacgagaat
    11641 gggaaaagca tacgtaaggt tccacctaag aaattcactc cgtcgagtgt ccatcccact
    11701 cccatattcc cataaccaga cacattgaaa acagcaaatg acgctaatgc catacccagc
    11761 aacacaacca gcacagccaa tgctttatta gacaaacgac gaatgaacaa cgcataaaga
    11821 atattaccta tatactcaaa aaacagggac cagcaaggtc cgttcaatgg aaacatctca
    11881 ccattaccac gaacttcata tcccacaccc ggcatggcag gaataaagaa tattgtacaa
    11941 agcaaagaca acataatcat ggaaatggcg acatgcgttc catcccattg cacacaacct
    12001 tgaatacaga acgtaatagc tcccaaaaca gcacccataa ttaccatcgg atgaagacgg
    12061 atcaaacggc gtttgaaaaa gtctttcata gtgaaattct tcccccaacg gtcatcatac
    12121 gcataaccga taacaaaacc cgaaagaata aaaaagaaat ccacagcaag atacccgtgg
    12181 ttgagagtct cgatattacc ggcactagca aaagcaaagc cttcaaatac atgataccat
    12241 attaccataa gagcagcgac tcctctcaat ccatcaagaa gatcataatg aggctttgta
    12301 tctgtaaatg ctgcagaaga gattttttcc ataataaatt aatagattta ataattaatt
    12361 ctttttaacc gttactaata atgctgcaaa gttacacaac ttaaaggctt ttaaatttgt
    12421 cctatgacaa aaaaacagta atacataaat tattttttag ctcgaagacg actaagtgtg
    12481 ggaagtgtta tacccaaata agatgcaata taccttaact tcacccgttg gcatatttga
    12541 ggaaactgtt gtttaaactc ctcatatctt tcttttgcag gcaaagtcag ccgttctttg
    12601 tgagaacgat gcaaacgcct gtactcattt tgatgaataa tcctccccca attagccaat
    12661 tcaatattag tctgaaacag cttggttaaa tcaactaatg atattttgta aacaactaca
    12721 tcttcaagcg tttccacaaa ttcctcgctc ggcttattat agtacaactc gtccatactg
    12781 aaaacaatac ctccttccca tgaaaaggag gttgttattt cttctccatt tacaagccag
    12841 aaagaacgcg tcattccttt ttctatgaaa taagctgatt tacaaaatgt attctccttt
    12901 attaactgat atttcttagg gaaacgacat aaaatcatac attttttcag ttcttgtatc
    12961 gtatcttcag aaaccggaca caaagagagc atattatcta taatgtttgt cataaaacct
    13021 cagtccattt aaaatacata taaaaaaaca ccaaatataa acacgggata taccttgttt
    13081 tcttttcagc caaaagtaca aatatatatt ggaaaacgac atcatttttt ccaaataatc
    13141 ggaatttcca agaccacccc atacaagaat gtccatatac ctcttttatt tattactttt
    13201 tgttcaaatt acaaagataa agcattcaaa tgccaatcaa gcttttaaaa cttcccattg
    13261 cttaatgcac cactctaaaa gaattgcaat agccttcaaa tcacttttca tataatctat
    13321 cagaaatttc ataccaagaa aatccaaaag aaataccaaa gaattgaaca ttttttatga
    13381 aaaacagccc ttgacagatt ggcagatgca ggctattttt gcattttaac aattataacc
    13441 cttaaaacaa aaaaatattt actttgcagt atgaaatatc tattatcaga agagtaaaat
    13501 cttaattaat aatctgctac tgctttaacc aacaagtcca atcacatgaa aaaaattata
    13561 acattacttt taatattgtt gtttaccaca aaaagcactt tctcccaatc accaaacaat
    13621 atagagaagt tcaccgtagt ctgtgtaaat gataaagata gtattttaaa caaaataaaa
    13681 atgtctactc cccaattcta caacatcgga aaaggtaaac gtatagagat aaaagtatgc
    13741 aatgaagaca gcatacaaat aagaagagta cgctgtcttt tatattattc caactccggc
    13801 aagaaagaat gtataggaaa aatatggatt tcccctctca ttggctacga aacctgctat
    13861 ttttgtatga acgtggatat ccccctaaca aaagacgaat ggcataaact aactttccga
    13921 ataaagagag gaaaaaatta taaggattac aaattcttga aacaacaagt acaagaagaa
    13981 aatatttgat aagaaaagag atattgacaa gaagaaaaac aggaagaatt gtttttattt
    14041 taagtttcag ctttaaaata aaccaagatt tattttatac cattctgatt atccttatat
    14101 ttgtcttttg ataataaaac tatgcaatct attaatttac aaaaacaatg agctatatcc
    14161 aaaacaatct acaagctggt gaagaaataa aatacaaagc agatattcac tggtatatat
    14221 ttgcatatcc ggtaatacta ctattattaa gcgttttctt ttcttctgca caaaccggat
    14281 ttttccatta tgttagctta tttctattat tgtccggatt attccaattg ataaaaagaa
    14341 ttcttcttaa gatgggcact gaatatgttg tcacaaacaa gaaagtcatt ctaaaatccg
    14401 gtattttaag ccgggatgcc cttgaattgg ttttaaacaa atgcgaaggg atacggatta
    14461 atcaaagcct catgggacgt atgctcggtt ttggttctat tgtagttact acaggcgggg
    14521 tcaccaacaa atttgacttt atcaccaatc ctataaagtt cagaaacgaa atcaatgcgc
    14581 agattcaata aatgaaaagc atttaaagaa tacaaagggg gcggatataa aagcttttat
    14641 acacaaaact gtaatggaac tcctctgtta ggataatata atctgcactt aggtttaagt
    14701 attgtattaa aggtaatcag gaataccaaa agaatgtttt aatatgttta ttgagaatcc
    14761 ttatcaatgg ggagtgtcgt atgactatgc tttacccttg tcagaaaaca cgcttttgca
    14821 catacattca cacggggcta tacatacgta caagcttatg cgtatgtatg taaaacgctt
    14881 tagtccagaa tgaaattcca tatcaaagac aaggacgttt tttaaaaaga tcaagagctt
    14941 ttcaagaaag ataaccgcct tttttttaaa gaacaagagt tttttttaaa atgtcttgct
    15001 ctttttttat cgctgccggg aattcgtaag ctatcattcc gtggaagtgt ctcccccctt
    15061 catgcgcatt cttacgagaa aaaagcttga aaacgctcta ctttatacca agctggaacg
    15121 gtctataaaa agagaatata tagctgacag caagcatatt atgtaaaaat caacctcaaa
    15181 acatagtgag ggcatgagag tataagtgaa agcaaatatt tttactattg tcatataagt
    15241 catttataat taacctatta tacatgcagt gagggcatga gggcataaat acccccgaac
    15301 tttctagtga gaaagataat acgtcaagga cactttccga aattgatcag agaacaaaat
    15361 gatctttata aaagctaaag tccgttgcag gtgagtctgg atatacttag ataaaataat
    15421 aaaaacaccc aatctttcta tatgtaagat tgggtgtttt tattataact cattgatttt
    15481 caatacttat tgcggagaga cagggattcg aaccccggg
//
