LOCUS       gnlProkkaCECFHELI_24   11753 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CECFHELI_24.
ACCESSION   gnlProkkaCECFHELI_24
VERSION     gnlProkkaCECFHELI_24
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 08:46:28
            Original ID  :: gnl|Prokka|CECFHELI_24
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11753
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11753
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2439:6753]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2440..6753
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11753
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11753
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             2..1213
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 63.3;
                     E-value: 2.7e-19)"
                     /gene_kind="transport"
                     /locus_tag="ctg24_1"
                     /transl_table=11
                     /translation="MPGIYQLSGKLNTIRELVNEAQGLTGDAFLNRAVLYRQREDLTSE
                     VVQIDIKSIMNGTSPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTL
                     EDLIIQAGGLKEAASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFIL
                     QPYDEVYVRRSPGYQAQQNVVIDGEILFGGNYAMTNREERLSDLVNKAGGPTNLAYLRG
                     AKLTRVASAGEKKRMGDVIRLMSRQLGEAMIDSLGIGVEDTFTVGIDLEKALTNPKGSA
                     DLVLREGDVVFIPKNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGYSDNARKSKKF
                     IVYMNGQVTKVKGSGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIAN
                     LIKK"
     CDS             1228..2376
                     /locus_tag="ctg24_2"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             2440..3159
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 2e-16, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             3180..4481
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_4"
                     /sec_met_domain="CTP_transf_like (E-value: 1.1e-12,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.1e-120, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.3e-62, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             4498..5622
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.2e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             5632..6753
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg24_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_6"
                     /sec_met_domain="Aminotran_5 (E-value: 8.6e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        5722..6729
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg24_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg24_6_Aminotran_5.1"
                     /locus_tag="ctg24_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             6750..6893
                     /locus_tag="ctg24_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             7096..8580
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_8"
                     /sec_met_domain="Polysacc_synt (E-value: 7.6e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             8534..9793
                     /locus_tag="ctg24_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             9802..10548
                     /locus_tag="ctg24_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKKF"
     CDS             10552..11592
                     /locus_tag="ctg24_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 tcgtcccggc atctaccagc tcagcggtaa actgaacacg atccgcgaac ttgtcaatga
       61 agcccagggt ctgaccggtg acgctttcct gaatcgtgcc gtcctttatc gccagcgtga
      121 ggacctgacc agtgaagttg ttcagataga tatcaagtct atcatgaacg gtacttcccc
      181 gaaccttgcc ctgatgaaga atgacattct ctacatcccg agcattcacg atctggaaga
      241 tcgtggcaat gtcacagttc acggtgaagt cgcgcacccc gattcctatc cctatgctga
      301 taacatgaca cttgaggatc tgatcatcca ggccggtggc ttgaaagaag ccgcctccac
      361 tgtccgcatt gatgtgtcga gacgaatcaa gaatccccgt agtaccgcgg ataatgatac
      421 tatcggtcag atgtatacct tctctttaaa ggatggtttt gtcatcgacg gtcagcccgg
      481 ttttatcctt cagccttatg acgaagttta tgtccgtcgc agtccgggtt atcaggcaca
      541 acagaatgta gtcattgatg gtgaaatcct tttcggagga aattatgcca tgaccaaccg
      601 tgaggaacgt ctttccgatc tggtgaataa agcgggtggt cctactaacc ttgcctatct
      661 tcgtggtgca aagctgaccc gtgtggcaag tgccggtgag aagaaacgta tgggtgatgt
      721 gattcgcctg atgagcagac aattgggaga ggccatgatt gactctttgg gtattggtgt
      781 tgaggatacc tttacggtag gcattgatct ggagaaggct ttgactaatc ctaagggtag
      841 tgccgacctt gtcctacgtg aaggtgatgt ggtcttcata ccaaagaata ctaatactgt
      901 aactatcaat ggtgctgtca tggttccgaa tacggtttct tatatgaagg gcaagaatgt
      961 ggattattac ctgaatcagg ccggtggtta ttctgataat gcaaggaaga gtaagaaatt
     1021 cattgtttac atgaatggtc aggtgacgaa ggttaagggt agtggtaaga aacagattga
     1081 gccgggatgt gagattattg tgcctggtaa ggctaagaag aaagggaaca tagctaatat
     1141 tttaggttat gctacttcct tcagttcttt gggaatgatg attgcttcta ttgctaatct
     1201 tataaagaaa taatagaatt tacttttatg tcagaacaac gacaggataa aaacttgctc
     1261 tctgaaccac acaagacaga aagtgatgag atagaaattg atttggtcga tatctttcgc
     1321 aagattattg ctattcgtaa aaaattatac aaagccgttg gaattggttt tattattgga
     1381 ataattgtag cggtaagtat ccctaaacag tatacagtaa aggttaccct ttctcctgaa
     1441 atgggtaatg cgaaggggag taatggttta gccggacttg ctgcctcgtt tttaggagat
     1501 ggggctctaa taggggaaag cacagatgcc ttgaacgctt ctctttcagc agatattgtt
     1561 tcttcaactc cttttttatt ggaactttta gaaatggaag tctccgtttc taaaaaggat
     1621 gataaaatga ctttggggtc ttatctcgat gaagagtcat ctccttggtg ggattatctt
     1681 ataggttttc cgggcatagt aataggagga gttaaatcat tattcggaga agatacggtt
     1741 cctgccagtg gagggcggca aggaactatc gaattgacga aagaagtaaa tgagaagatt
     1801 aattttctta aaaagaagat tagtgcatcc attgataaga aaaccgccat aacgagcatt
     1861 acggtcacct tacaaaatcc gcagatcact gcggttatag cagattctgt cgttcataaa
     1921 ttacaggaat atattattgg gtatcgaact tcaaaagtaa aagaagactg tgcgtatttg
     1981 gaacggttgt ttaaagaacg tcagcaggaa tattatgctg ctcaaagaaa atatgcggat
     2041 tatgtagacg cccatgataa tgtggttctt caaagtgtac gtgctgagca ggagcgttta
     2101 cagaacgaca tgagtttggc ttatcagata tatagtcagg ttgctaatca gttgcaggta
     2161 tccagagcca aagtacagga ggaaaagcca gtctttgcag tagttgagcc tgccgttgta
     2221 cctttgaaac cttcaggtat gggactcaaa atttatattt tattatttgt gttcctgtcc
     2281 gtatctggta ctctcgtgtg ggtgtttttt ggcaaaagtc tgctggctag cttgagaaaa
     2341 gaactgaaaa ataaggagat agaacaggat aaatgatgct aaaacgtcgt ttacaacatt
     2401 cttacatcaa ttaaattcac ttactatatt attaaacgaa tgatacgtac agctatgata
     2461 atggctgcgg gcatgggaac ccgttttggc caatatacag aattgatacc taaagggttc
     2521 gtcaaagtgg gaggtattcc aatgatagtt cgttctattg atactttgtt atcatgtggc
     2581 attgagcgaa ttgtaatcgg tacaggatat aaacaagaag tttatgaaga attgaagaca
     2641 gactatccta tgcttgaaac ctgttttagt cctcgttatg ctgaaacaaa tagtatgtat
     2701 actttatata atacgcggga gattctgggc aatgatgatt ttttattgtt agagtcagat
     2761 ttgatttttg agaaacaagc aataatgagc ttattggagt gtcctgcggc agatgcaatg
     2821 ctaatagctc cagtgacaaa gtttcaagat cagtattatg tggaacatga tgataatttt
     2881 cgcctttctt catgttctgt caataagaat aaactaaacg ctaaaggcga attggtcggc
     2941 atccataaac tatccggttc cttttacaaa ataatgtgtg ctgattatgc gagtattgtt
     3001 gatgaacaac ccaatttggg atatgagtat gaattactac gaatatcttg ttctcaatct
     3061 cctgtttatg tgcataaagt agaagggctg aaatggtatg aaatcgatga catatcagat
     3121 ttggaatatg cagagaaata tattgttccg tattgttaat taaaataata tatcaaatta
     3181 tgagtaagac agtttatatt gggatgactg cggatattat gcatccagga cttatccgca
     3241 ttattaatga ggctactaaa tacggtgatg ttataattgg tcttcttaca gataaagcta
     3301 ttgcggagca taaacgcctt ccttatctga cctatgaaca acgaaaagag gtagttcaga
     3361 atattaaagg cgtatgtaaa gttgttcctc aagaagaatg gagctatgtt gagaatctca
     3421 aacgcattaa acctgactat ataattcatg gtgacgactg gaaaaccggg cctttacgtg
     3481 aagaacgtgt gcgcgtattt gaagtgatga atgaacaggg aggaaaggtt atcgaaattc
     3541 catatacttt gggaattaat tcatcttctt tggataaaga tattaaggct ataggtacaa
     3601 cccctgatgt acgtttaaaa tcacttcgtc gtttgataaa tgccaaaccc gtagttcgta
     3661 ttttggaagc tcatgatgga ctatgtggct tgataattga aaatcaggaa atattaaaag
     3721 gggataagag ggaagtattt gacggaatgt ggtctagtag ccttacggat tcaaccagta
     3781 aaggtaaacc tgatattgag gcggttgatt taactacccg attgcaagat ttgaataata
     3841 ttctggagtg tactactaaa cctattattt ttgatggaga tacaggtggt aaaattgaac
     3901 atttcgtatt tacagtacgc actttagaac gtcatggaat ttcagctata ataattgaag
     3961 ataaagttgg attaaaaaag aattcattgt ttggtacaga tgttattcaa actcaagata
     4021 caatcgaagg tttctgtaat aagatcaaag caggaaaggc atctcagatt actgatgatt
     4081 ttatgattat cgctcgtatt gagagcctta tagcgggaaa gccggtaagt gatgctttag
     4141 agagagcttt tgcatatgtc caagcgggag cggacggtat tatgatacat agcaaaaata
     4201 agtcgggtga agatataaaa gaattttgtt tggcgtttcg aaaacagtat gctcatgtac
     4261 ctatcgtggt tgtgcctact acatatgatc atatttatga gtctgaattg tgtgattggg
     4321 gtgtgaatat aattatttat gctaatcata tgcttcgtgc cgcttatcct gctatgatga
     4381 atgtcgcaaa gataatatta gagaatgaac gtgctttaga ggtgcgcgaa ctgtgtatgc
     4441 ccataaaaga aatattggaa ctgattccag gtactaaata aaaagaggaa tatcattatg
     4501 ttaagcgtag aaaaagttta tgaaacgttt ctgagtcatg acgttgattt ttttacagga
     4561 gttccagact cattactaaa aaatatttgt gcctatatca cagaccatac ttcacgtgag
     4621 aaacatatca tagctgctaa tgaaggtgcg gctgtaggaa ttgcttcagg ttattatatg
     4681 gcatcaggta aggttcctgt ggtttatatg caaaattccg gcttgggtaa tactgttaat
     4741 cctctgctgt ctcttgcaga tgaacaagta tacagttttc caatgctttt gatgattggc
     4801 tggcgtggtg aaccgggaac aaaagatgaa cctcagcata aaaaacaggg tgaggtaact
     4861 ttagatttgt tgaaagcaat gcggattcct tatataattc ttgattcaaa tgagaatgat
     4921 gcatttattc agctccatga tatcatacaa tcagcaaaaa ctaagaatat tcctcatgca
     4981 ataattattc ggaaagatgt ttttggcaaa tataaacttc aaaaagagtt cggatgtaat
     5041 tatcctttat ctcgtgagga tgctttgcaa atagttgtgg attatctgcc tgaaaattca
     5101 gtggtcgttt ctactactgg caagctttct cgtgagttat ttgaatatcg agaaatgaaa
     5161 gagcaaggtc atgaacatga ttttctcacg gtaggctcta tgggacatag ttcatcaatc
     5221 tctttgggta ttgctatagc aaagcaagat agacctgttt attgcttgga tggtgatgga
     5281 gcatttatta tgcatttagg ggcaattagt aacattggcg atttatctcc taaaaactat
     5341 tatcatattt tgtttaacaa tggtgctcac gagtctgtag gaggacagcc tactttagga
     5401 tttagtttag atattccggc tattgtccgg gggagcggat ataagcatac ttatactgtt
     5461 tgtacaaaag ttgaaattga agaagcaatg aagcagcttc caaagttatg tggtcctgtt
     5521 ttgttggaaa taaaggttaa aatagattct cgggagaatt tgggacgtcc cacgactact
     5581 cctatagaga ataaggagca ttttatggat tttttaaaat aaatatattc gatgaaaata
     5641 gaaagaaaaa tattattaaa tcctgggcct gccactacta ctgacagtgt aaaaatggca
     5701 caagttgttc cggatatttg tcctcgcgag aaagaattcg caggtatgat gaaacaactt
     5761 cgggacgatt tggtcagagt tgctcatggg aatttggaaa aacataccgc tgtattattt
     5821 tgtggctcag gaaccatcaa tattgatata tgtctaaatt ctcttcttcc tgaagacaaa
     5881 agggtgctta tagtgaataa tggggcatat agtacccgtg ctgtagaagt gtgtcaatat
     5941 tatggtttgc ctcatattaa tttggaattt tccgtttacg aacgtcctga tttatcggtg
     6001 gtggaaaatg tgttgcaaga aaatcctgat atagctatgg tttatactac tcatcacgag
     6061 acgggtacag gaattctgaa ccctattcgc gagatgggcg ctatagctca taaatatcag
     6121 gctaaatttg tcgtcgatac tacttcttct ttgggcatga ttccttttga tatagagaaa
     6181 gataatgtgg atttttgtat ggcatctgct caaaaaggac ttcaagcgat gacaggtctt
     6241 tcttttatta taggcaatga ggaacagatt aagttttcaa aaaaatatcc caagcgttct
     6301 tactattgta atctttattt gcagtatgag aattttgaga gaacaggtga aatgcatttt
     6361 actccaccgg tacaaactat ttacgccact cgtcaggcat taaatgaata ttttgaagtg
     6421 ggtgaagaag ctaagtttgc ccgtcacaaa agagtttttg aggctattca ttcaggtata
     6481 aatgaaattg gtcttaaaag tgtaataaag cgtgaatggc agtcaggact ggttgtctca
     6541 gttcaatacc cagaagatcc caactgggat tttgagaaaa tacatgatta ttgttatgag
     6601 cgtggattta cgatttatcc aggtaagata tcaactgagg atacttttag aatctgtgct
     6661 ttaggagaga tagaagtaga tgatattgag aacttcttta aagtactaaa agctgcatta
     6721 aatcattata acgtcacatt accgatgtca tgattgcaga aatattattg aagattcgtc
     6781 atttttattt ttcccttcgt ggtatacact tccatccgga aagtgttatt tctggagtgc
     6841 ctattcgtag ctttcgctta gtaggcaaat atggcaatat taatttgagg tgatgcatta
     6901 ggagttcttt attcttataa aaaggcatcg gtagttatag gagataatgt ttgtgtaggg
     6961 taatttgctt ttagtgggag agaccatatt agaattgcgg taaggggcga agaagataat
     7021 aaccaattag tgagaatatt ggaaaaatat aattgatatc ggtaaatgta gttgttttta
     7081 tactgtattt aagtaatgga aaatctaaag cagaaaactg tatcaggaat aatgtggagc
     7141 gctatagaac gtttctcttt acaaggagta cagtttataa ttcaaataat attagctcgt
     7201 ttgttactac catcggatta tggtatgatc gggatgttag ctatttttct tcaagtcgct
     7261 caagtattta tagatagcgg ttttacaaat gctttaatcc agaaaaaaga tagaactgaa
     7321 gaggattttg ccactgtctt ttattttaat attcttgtcg cagtattatt ctatggtata
     7381 ttgttttttt cggcttcttt gattgcagac ttttataata tgccgacttt agttcttgta
     7441 attcgtttta tagcattgtc gttgataata aatgctttat cggctattca cagaacgaaa
     7501 ttaattattt ctgtaaactt taaaactcaa tctaaaattt cattaggtgc agcttttata
     7561 tcaggcgtga ttggaatatg gatggcttat gtcggttgcg gggtttgggc tttagtttgg
     7621 caaactctct taaatagtat aattttgaca attttgtttt actgtttagt tcattggaaa
     7681 cctttacata ctttctccaa aagttctttt gaaagattat tcaatttcgg atctaaatta
     7741 ttgatctcaa gtcttatcaa tacagtatat cgtaatctgt ataccattgt aataggaaaa
     7801 aagttttctg ttgtagagct tggttactat acaagagcag aacaatttgc tatttttcct
     7861 tccaataatt taaatgcttt agtttctaga gtagcgtatc ctattttaag ttccattcaa
     7921 gatgatgata aatgtttaac aaacgcatat cgaaattata tcagattatc ctcatatata
     7981 atttttcctt taatggtagg tttacttgtt ttggctaatc ctattattag tctattgtta
     8041 acagataaat ggtctggggt tgttattctt ttacagatat tatgtttgga ttggatgttt
     8101 gatcatttga gccaaattaa tttgaattta ttatgggtta aaggaagatc tgatctgtcg
     8161 ttacgtcttg aaataataaa aaagacgatt gctatattca ttctttttgt gtcaattcca
     8221 tttgggcttg aggtgatgtg ttggggtaga gttatttact ctctgatagc gacatatttg
     8281 aatacatatt atactaattc tcttattgat ttgaccttaa agttgcaagt taaagatgta
     8341 tttccaagtt taatactctc tttcataatg ggggggatcg tttttatatg tatttctttc
     8401 tttgaaactg atatagtaaa aattgtgatt ggatgtatta ctgggatgtc cttctatatt
     8461 ttactttctt ttctttttaa gctagattct tttttttgta ttttaacatt gatcattaaa
     8521 actaaaaaca tagatgaaaa tattaaaaaa gatttttcaa gtaatagtaa agataattaa
     8581 ccattgtgtg ccagttgata gtagatcatt gtattttatt cctcatccta attgtagaac
     8641 agataaatat gatattataa attattcgtc agataatgtt ctcgttctgt taaattattt
     8701 gctaaaaaaa gatagtgctg aatattataa aatatatgtt gaaatttatg attcttctcg
     8761 tatttcagaa tatcaagaat atatttatgg cataaatcct aatattaggt gtactttttt
     8821 atgtgcatgt gttggacgtt ttttctttaa taaagtatct tttaaggata tgttgtatgc
     8881 ctttttttgt ttttgtagag caagtaaatg ttttacagct actttttatt atgatttttc
     8941 atttaaaaaa cgctctcaac agattatttg tttggggtat tatactccat tcaaagatga
     9001 ttatcatatg ggagatcatt cttatgataa atttcgtaat acaacatgta actcatttga
     9061 ttactctatt gctacttctt gtttaagtgc tagaataatt tcaatagatt gtggaatctc
     9121 atatgataaa ttcaaagtct taggatttcc cagaaatgat ttgttgatat cgaaaaataa
     9181 ttgcaatgtt attaaaagag aaatttcgaa atttgcggga tatgatgtaa ctaaatatat
     9241 agtttatact ccaacttttc gtgattatga gactgttact gaaggtaatt tgcgttcaat
     9301 actcggatat gttgattgtg atttgttgaa gttatcgaaa atactattga agtttaatgc
     9361 ggctttaatt cttaaattac atcctttgca gaataaaaca gtcttaaaaa aagatttacc
     9421 caaaggtata cttgtttttg aacaaacata taaatatgga ttgtatgatc ttttgtcatt
     9481 ttcagatgga atgattactg attatacttc tacctatttt gattttttat tggtaaataa
     9541 gccagtcata tttaatttct acgatattga agaatatcgt agagtaagag gtttctcatt
     9601 tgagccaata gaattttttt gtgcaggtga tattgtttac aattataatg aattgataga
     9661 tgctgtgatg ggacttctgg ctgggaaaga tattcatgct gaacatcgac gtcatatttc
     9721 tttattgatg aatcaatttc aagatgataa ttcaacaaag agaatatgtg acatattttt
     9781 aaatgaaata taataaataa aatgaattat gcatttgtgg tgcaggcacg tttaggttct
     9841 acacgtttgc ctggaaaaat attgaaacct ttctatggta atcaatcgat tcttgactta
     9901 atggttcata agctttctgc tatatcgaat attccagtaa ttattgctac aacaaattct
     9961 gttatcaatg aacctattga aaagaaggca cttgcattag gggtaaagtg cttcagaggt
    10021 gaggagaatg atgttttaaa acgattcatt gatgttgctg aatattttga tatacagggt
    10081 atattccgaa tatgttctga taatccattt ttagatgtac atgcggcaag gcaattggtc
    10141 gaaatagcaa tgaaatcttg taacgattat ataagttttg atattgatgg tactccatca
    10201 attaaaactc atttcggttt ttggggagaa tttgtaacgc ttgatgcgct gaagcgagtt
    10261 ataggattta ctgatgattt attgtatcgt gaacatgtta ctaattatat atatagtcat
    10321 cctgaacttt ttaatattca atggatttca ggatctccag tcgtgtcaaa acatcataat
    10381 attcgactca cgattgatac gttagaagat ttttctgtag cacagagaat atatagggat
    10441 ttacaagaaa aaagagtgga aatatcgata gaagtgattg tagactatgt tcgaagacat
    10501 gcagaataca ttcaactgat gaaacaacaa ataaaaaaaa aattctaaat aatgaagaat
    10561 acttatatta ttggtgaaat agggcagaat cataatggtt ctgttgactt ggctaagttg
    10621 attattgaat taatctcacg acctgtacat gaggatgttt ttggtatgga tttcatgcca
    10681 atgaatgctg ttaaaatgac taaaagagat ttatcagaag aattggctgt ttctcaaatg
    10741 aatcaaatat atgacaatcc taattctttt gggcgtactt atggtgaaca tcgtgctttt
    10801 cttgagcttg atgatcaagc gcattttgag atttataaat atgctaagtc attaggatta
    10861 gattttatcg agacgttatg tgccaaagga tgtctgtctt tgcttaaact gttcacaccg
    10921 gataggctaa aagttgctag tcgtgatttg actaacttac cattgcttga agcattagca
    10981 gaaactcata ttcctattat attatcgaca ggaatggctg gtcaaagaga acttgacaat
    11041 gcattagatg tgataacgag atatcatagt aatatagcta ttctacattg tgtatctcag
    11101 tatccaactc atccaaataa tttgaatcta cgtacaataa catatttgaa gaagcattac
    11161 aataagtttg agataggttt ttctgatcat acaataggta tttctgctgc tacagctgct
    11221 gtagcgatgg gagcggaaat tatagaaaag catgtaacaa ttgatcggca tatgaaagga
    11281 acagaccagc ttggctcttt aggtccagat ggggttaatc gtatgattcg agatattcgc
    11341 atagcagagt gttggcttgg tactgaagat ctttatatag aaaaaggggt ggagaagtct
    11401 aagataaaac ttgaacgttc tattgccact cgaaaatata ttccagcagg tagtattatt
    11461 caagagtcgg acattcattt actgagtcct ggtgatggtt ataaatggat agataaaaaa
    11521 aatgtaattg gtcattttgc taaacaagat atatcagcga atgaaataat atatcctgat
    11581 tttattgaat agatatattc ctactgcaac ttgtattacg gtatagagta ctgcctgcta
    11641 taagctaagt agtgattaat aaataagggt aaaatactaa aaaaatgaaa gagataaagc
    11701 ttatacttac agatattgat ggcgtttgga ctgatggcgg aatgttttat gat
//
