LOCUS       c00218_gnlPro..        13639 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ALOPODML_218.
ACCESSION   c00218_gnlPro..
VERSION     c00218_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 17:15:35
            Original ID  :: gnl|Prokka|ALOPODML_218
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 8913
            Orig. end    :: 22552
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13639
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[18913:22313]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13400
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13639
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13639
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(12..197)
                     /locus_tag="ctg218_18"
                     /transl_table=11
                     /translation="VLQGKTPLQTYLPLACTTGAGAGAVVCCCCCCWEQEATRQAAPAM
                     ARIAMFFIIRIKYSVC"
     CDS             complement(378..980)
                     /locus_tag="ctg218_19"
                     /transl_table=11
                     /translation="VQQQMSGLANAFLALLPPDQASLPAAGAEARWLADTAVVQSAAIA
                     RDNRTVLFGWLNNILVNSNLRDRGLCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGRE
                     HSCVYVNAAGKGLQGSIVLDAWKNCGHLVTLTQKDREGGKWDEDWREPFVSKAFPEGHS
                     YGMEHHLVWPGWARKRPMLVQRIFQSDQQNEAKAAAE"
     CDS             complement(1106..2683)
                     /locus_tag="ctg218_20"
                     /transl_table=11
                     /translation="VHIVGDEDQCSFIMLQSLHQGFYGQKVQVGGRLVHQQEVGRIHQE
                     FDQAEPRFFPAGKNADAFFHIQPPEQEGTQDGTRFFLPDFSAAFHDFLQHGIFRIQVFR
                     SRLGEVADARRGTGSALSGVNGDDARQDFEKSGFARAVRAYKNSALPAFHQQVQVFINP
                     AVAIGLADFFQLNDFLGAARRLGEVEFKYFPAGYRFLNDFHLFQLLDAALDLPGFGIDG
                     AETVNKFLNVRYFLLLVAVGRLKLLEAHVLLLEEVRVIAAVFHQFFVVDVVHAFHQLIH
                     EIPVVGNHQDGSGVVFQVSLEPQQGQEVQVVGRFVQHQEVRLQDKELGQVRAHDPAAGH
                     FPGWAMEVAFPKGQPFENFLGFGLQLVTVGGVESVNGFRVFRRIRFVGVFRRPDGVDGL
                     FHFRRDAQGDFQNGFILRFAGFLGKIAHDGVFIHADGAFVRRVFSQNHAEQGGFACSVG
                     ANQSHPFPPVNGHFRFPEQGPSGVGFCEIFDRQHGEERMYSTGMERGRQEPSGRRQAFL
                     KALLDFYA"
     CDS             2882..3400
                     /locus_tag="ctg218_21"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPAAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESADNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LIEKMEKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLVEPDEDGAPPGA
                     LRENEEAGQ"
     CDS             3345..3548
                     /locus_tag="ctg218_22"
                     /transl_table=11
                     /translation="MKTGRPPVHSGKMKRPDSSPPPRFSPPLFSFPARPFPVWVPARPS
                     PFQACRNREKRVYCGQHAKVSR"
     CDS             3502..4275
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg218_23"
                     /sec_met_domain="adh_short_C2 (E-value: 1.6e-75, bitscore:
                     244.9, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKNGFTVGSMQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILI
                     SRSPSSCGGAAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGIT
                     RDSLMLRMKEEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQA
                     NYAASKAGLIGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKE
                     QGSVEDIAALTAFLASDDARYITGQVIACDGGMTM"
     CDS             complement(4227..4709)
                     /locus_tag="ctg218_24"
                     /transl_table=11
                     /translation="MLRTFVRFPVRLFRGTPHEERSSRYGDHAQGRSRHGNRFRVGFKT
                     CRISGSFNELMDLARCADQLPGRQVIRNGKGRTGSAVQFPFLQRGSAFSPLACAGNARG
                     IFRGRAGGIIFFPAPGQQGASSQKAGNKENAAHGMEKTGMPYIVMPPSQAMTCPVM"
     CDS             4713..5504
                     /locus_tag="ctg218_25"
                     /transl_table=11
                     /translation="VSISPFWISETEIPWELYTAFMENGRPRAKDGQLLEEQPDDELWD
                     SVTQPTAPYTAMNLGMGHGYEHGLPAISMSHHAASKFCEWLSAQTGHYYRLPTEAEWEY
                     ACRAGSPGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSKKPNKWGLRDMHGNVAEWVLD
                     SYVPDAYGKRSGLPAKDPLVIIPGAPHIIRGGSWEDDPDSLRSAARRASTPAWNRQDPQ
                     NPKSIWYLTDGGMIGFRVVRPMNIPDIMTMHRLWNFSKGEP"
     CDS             5518..5718
                     /locus_tag="ctg218_26"
                     /transl_table=11
                     /translation="MTIALRTEQSSDHAETEHVTREAFWNYFVPGCHEHYLLHIMRVSP
                     SFIPELDAVAVHGSRIVGKHR"
     CDS             5762..5887
                     /locus_tag="ctg218_27"
                     /transl_table=11
                     /translation="VLGMGPIAVLPKYQRRGIGRRIICMRRPSRSVSCKGVPYPA"
     CDS             complement(6182..6973)
                     /locus_tag="ctg218_28"
                     /transl_table=11
                     /translation="LGNSKFATSCHPKGIINMKKTLTFLIAMGSFAVSSEAATVFNYYT
                     PGTDNYNSTIHGFYLGLGSSSLAPSDSSSPSSLSGEIRLDSFTLRGAANNLGANVTYGF
                     LVLNGSDNSVIGWSTNTGTTAAGINLTFSFSSLDGSPLLLDAALTYRFLAVSQSVMDLM
                     QDTSKTYLYAAGGTAAPTANTEGDTVTISGGLTAPGIRGHYDAEGAPGDSVVITGANGT
                     NTFSLLSPIFTEIRGEMVPEPATVSLGLLGLAALMMRRRRA"
     CDS             complement(7195..7482)
                     /locus_tag="ctg218_29"
                     /transl_table=11
                     /translation="VLILDRSRTIVTDITSRLLVPYPLKVIPDNVRLLSSDVMETESFR
                     VPKSAVWEVKSEYPTIELSSRVVFAVALRLMPAERIRVDNNFFMVSILIK"
     CDS             complement(7492..7584)
                     /locus_tag="ctg218_30"
                     /transl_table=11
                     /translation="VLFHNPWSFRFVFRPTPQLTLLFLALNRAV"
     CDS             complement(7586..7828)
                     /locus_tag="ctg218_31"
                     /transl_table=11
                     /translation="LTNLFLGKEGVVDVELFDGFSQSCVHENLINLLVAEFQAAVGIVR
                     SAVAKIDAGAKISGDYGNGQGPFRAQRGVNDGPAV"
     CDS             8179..8586
                     /locus_tag="ctg218_32"
                     /transl_table=11
                     /translation="MQSPASLSIRNSPSFQQSISPHGPDRCGSVRRQQTPSPKQGKGVG
                     KWLSLNLYPPFPSMNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPDE
                     FLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(8620..9435)
                     /locus_tag="ctg218_33"
                     /transl_table=11
                     /translation="MMAFIEPHIHMVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSAD
                     GFRDYFVQLTECEPARAAKFGMDHYTWLCINPKEAQDVAFARNVMKLIPEFIDRPNVLG
                     IGEIGLNRNTSHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLD
                     PCRVLVDHCEEHTFPLVKEAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADW
                     GDSDPLVLTALACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(9438..9710)
                     /locus_tag="ctg218_34"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             9728..9883
                     /locus_tag="ctg218_35"
                     /transl_table=11
                     /translation="MRKASSSRNRQQNDNHSKLINSNLFPRLFKNPKSAGNSRRGLPSG
                     LEPGIL"
     CDS             10001..10612
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg218_36"
                     /sec_met_domain="SucD_FumR (E-value: 1e-13, bitscore: 42.6,
                     seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LFLAGHLAGNLLIFGGPEWINTYAHGLHSMPEAALWGIRAGLAVI
                     FIIHVWLTIQLKLENHAAREPYVFKNTIKATLSSRYMIYTGLTVLVFLIYHLYQYTLRV
                     GYDPAQFTTFISDGTVETFDVYKMIVTGFSNVWCSAFYILAVLMLFSHLRHGVQSIFQT
                     VGVDSRKIRPFYNFIAIAYGAIICLGFISVPVSVLLGIIK"
     CDS             10634..12592
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg218_37"
                     /sec_met_domain="FAD_binding_2 (E-value: 2.6e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 7.4e-38,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             12570..13400
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.6; E-value: 9.2)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg218_38"
                     /sec_met_domain="Fer2_3 (E-value: 1.7e-23, bitscore: 74.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 5.4e-11, bitscore: 34.2,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.9e-06, bitscore: 19.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LPSAATSKDSQYINTQKKDYNMAKTLNLTLKVWRQENREAKGRIE
                     TYAAKDIPVDASFLEMLDIVNEGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPER
                     QVTTCQLHMRKFKDGDTVWIEPFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAP
                     NANNIAVEKVKADAAFDAAACIGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSK
                     RVLAMMKQMEAEGFGNCTNQYECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
     CDS             complement(13414..13638)
                     /locus_tag="ctg218_39"
                     /transl_table=11
                     /translation="RKMGPSLSDGACLGFVRHCQVRSPGLLGAFRCNNFLRCATMRKQL
                     SGILFLVQGNLVMKKLPTADAAGSFYRAS"
ORIGIN
        1 ggttccagta gttaacaaac actgtattta attcgaatta tgaagaacat cgctatcctc
       61 gccatcgccg gcgccgcttg cctggtcgct tcctgctccc agcagcagca gcaacagcaa
      121 accaccgctc ctgctcccgc tccggttgtg caggccaagg gcaagtaagt ttgcagcggg
      181 gttttgccct gcaacactag caaattatcc aattaatccg cactcggtgt acgcactgag
      241 tgcgttttta tttgccctga gtccggattc cctccgccat ttgccgattc gccgggattt
      301 tccttaaaaa cggaggatac cgcaaaccgc cgcggcgcag caccgtgtgc cggttcctgc
      361 cggatcaggc ttccccttta ttcagcggcc gccttcgcct cattctgctg atcggactga
      421 aatatccgct gaaccagcat ggggcgtttc ctggcccacc cgggccagac caggtgatgt
      481 tccatgccgt aggaatggcc ctccggaaag gccttggaaa caaatggttc ccgccagtcc
      541 tcatcccatt tgccgccttc ccggtccttc tgggtcagcg tcaccagatg cccgcagttc
      601 ttccaggcat ccagaacaat ggagccctgc aatcccttcc ccgcggcatt gacatacacg
      661 caactgtgct ccctgcccgt tcctcggtct cgaatcgtca gccctatgcg gaaatacttc
      721 acggggcggc ggcgcaggtc ccggtacaaa tcctgctgga cctgccagca cagccccctg
      781 tcgcgcaggt tggaattgac cagaatattg ttcagccagc caaacagcac agtcctgttg
      841 tcccgggcaa tcgcggcgga ctggaccacg gccgtgtccg ccagccacct ggcctccgct
      901 ccggcagcgg gaagagaggc ctgatccggc ggcagcagcg ccaggaaggc attagccagc
      961 ccggacattt gctgctgcac gtaaggttgt tgtatataat cctccgccgg aggagtacag
     1021 caggaactcc atccgcacaa aagggcggca gcaagcaaaa gcctgaatgt ctgcgtggtc
     1081 ggcatggcgc gccaaggcta gcaaactacg cgtaaaaatc cagtaaagct ttcaaaaatg
     1141 cctgcctccg ccctgacggc tcttgccttc ccctttccat cccggtagaa tacatcctct
     1201 cttcaccatg ctgacgatca aaaatctcac aaaatcccac gccggacgga ccttgttcag
     1261 ggaaacggaa atgaccatta actgggggga acgggtggct ctggttggcc ccaacggagc
     1321 aggcaaatcc accctgttcc gcatgattct gggagaagac acgccggacg aaggctccat
     1381 cagcatggat gaatacgcca tcgtgggcta tcttccccag gaagccagcg aaccgaagga
     1441 tgaaaccgtt ctggaaatcg ccctgggcat cacgccggaa atggaacagg ccatccacac
     1501 catccggacg gcggaaaacg ccaacaaaac ggatacgccg gaatacgcgg aagccattga
     1561 cactttcaac gccgccaacg gttaccagct ggagcccaaa gccaagaaaa ttctcaaagg
     1621 gctggccttt cgggaaagcg acttccatcg cccagcccgg gaaatgtccg gcggctggat
     1681 catgcgcgcg tacctggcca agctccttgt cctggagccg gacctcctga tgctggacga
     1741 acctaccaac cacctggacc tcctgtccct gctgtggctc cagcgatacc tgaaaaacta
     1801 ccccggagcc atcctgatga tttcccacga ccgggatttc atggatgagc tggtggaaag
     1861 cgtgtacgac atcgacaacg aagaactggt ggaataccgc ggcaattact cggacttcct
     1921 ccaacaaaag gacgtgcgct tcgagcagct tcaggcggcc taccgcaacc agcagaagga
     1981 aatagcgcac attcaggaat ttattgaccg tttccgctcc atcaattcca aagccgggca
     2041 agtccagagc cgcatcaagc agctggaaaa gatgaaaatc attcaaaaac cggtagcccg
     2101 caggaaagta tttaaattca acttccccca gcctccgcgc agcacccaga aagtcattga
     2161 gctggaaaaa gtctgccaat cctatggcga ccgcagggtt tatgaaaacc tggacctgct
     2221 ggtggaacgc ggggagcgca ctgttcttgt aggcccgaac ggcgcgggca aatccactct
     2281 tctcaaaatc ctggcgggca tcatccccat tgactccgga caacgcactc ccggtaccac
     2341 gacgcgcatc ggctacttct cccaggcgcg aacggaaaac ctgaatccgg aaaataccgt
     2401 gctggaggaa atcatgaaat gcagcgctga aatccgggag gaagaagcgc gttccatcct
     2461 gggttccttc ctgttccgga ggctggatgt ggaaaaacgc gtcagcgttc tttccggcgg
     2521 ggaaaaatcg cggctcagcc tggtcaaatt cctggtggat ccgcccaacc tcctgctgat
     2581 ggacgagccg accacccacc tggacctttt gtccgtagaa gccctggtgc aggctctgaa
     2641 gcattatgaa ggaacactgg tcttcatctc ccacgatgtg cacttcatcc gttccctggc
     2701 acaaaaaacc ctgcatgtga accgggggac catcaccgcc tacgcaggtg gatatgacta
     2761 ctatctggaa aagtcaggca ttctggacga tgaaaaaggc ggcatcacag cggaataagg
     2821 ctcttttttc agtttcccct ttttccttgc cgtggatttc atcctgcctt aaaagaacag
     2881 gatgaaggct tttcttgttc ctctcttata ttctgcgctt ctgtccggag cctctcttgc
     2941 atttggtgaa acggccgccg gaacggcttc ccccgcagca gcggctccgg cggaaaaaat
     3001 tccttccgcg gaatccctga tcaaccaggc cttttccttt gccatcaata tccagcagac
     3061 gttggcaggc gttcaggaca aggaaagcgc ggacaacgcc gtcaaaacgc tgcaggacat
     3121 tcagaaggac atccggcatt tcctccagct tcaggataaa ttgaacgatg cggaaaagga
     3181 gaaagaagac gccttgatag aaaaaatgga aaaacgaatg gaaatgctgg acaaccgctg
     3241 caggcaggaa ggcaaacgcc tgtttgaggc ccgctattac ggttccgccg ccttaaagga
     3301 cattttggaa aattcggatg aattcagcga cctggtagaa ccggatgaag acggggcgcc
     3361 ccccggtgca ctccgggaaa atgaagaggc cggacagtag ccccccgccc cgtttctccc
     3421 cccctctttt ttcattcccg gcacgcccct tccccgtatg ggttcctgcg cggccaagtc
     3481 catttcaagc ttgccgaaac cgtgaaaaac gggtttactg tgggcagcat gcaaaagtta
     3541 gcaggtaaaa cagccatcgt taccggcgcg ggccgcggaa tcggcaatgc cgtcgcgcgc
     3601 cgcttcgctt cggaaggagc cagggtcatc ctgatcagcc gcagtccatc cagctgcggg
     3661 ggggccgcag aagaaatcaa caaggaattt ccggattcct gcaaggccta cccctgcgac
     3721 gtagcggatt acgcggccgt tcaggaaacc atggccgcca ttttgaaaga cttcccgcag
     3781 attgacatcc tggtgaacaa cgccggcatc acgcgggact ccctgatgct ccgcatgaaa
     3841 gaggaagact gggatgccgt tctggacacc aacctgaaaa gcgcgttcaa tacggtcaag
     3901 gccctccagc gcgttctcat gaaatccccg gccgggcgca tcatcaacat gagctccgtc
     3961 atcggtctcg tcggcaacat cggccaggcc aattacgccg cttccaaggc gggcctcatc
     4021 ggtttcacca aatcactggc tcaggaattc gctccgcgca aagtcacgtg caacgccatt
     4081 gctcccggct tcatctccac ggaaatgtcc aatgccattc ccgacaatct caaggaagaa
     4141 atcgttaaga aaataccttt gaaagaacaa ggttccgtgg aagatatcgc cgccctgacg
     4201 gccttccttg cctctgacga tgcccgttac atcaccgggc aggtcattgc ctgcgacgga
     4261 ggcatgacga tgtagggcat tccggttttc tccattccat gcgcggcatt ttccttgttt
     4321 cctgctttct gggaggaagc gccctgctgg ccgggtgccg ggaagaaaat aattcccccc
     4381 gcccggccac ggaagatgcc gcgcgcatta ccagcgcacg ccagtgggga gaaagccgat
     4441 ccgcgctgca aaaacgggaa ctggaccgcg ctgccggtcc tgcccttccc attccggatg
     4501 acctgccgtc ccgggagctg gtcggcacaa cgcgccaaat ccatcagctc attgaagctt
     4561 ccggaaatcc ggcacgtttt gaatcctaca cggaaacggt tcccgtggcg ggatcttccc
     4621 tgcgcatggt cgccataccg ggaggaacgt tcctcatggg gagtcccgcg gaagagccgc
     4681 accggaaacc ggacgaaggt ccgcagcata aagtgagcat ctcccccttc tggatctcgg
     4741 aaacggaaat cccctgggaa ctttatacgg ccttcatgga aaacgggcgt ccgcgcgcca
     4801 aggacggcca gcttctggag gaacagccgg atgacgaact gtgggactcc gttacgcagc
     4861 ctaccgcccc ctacaccgcc atgaacctgg gcatgggcca cggctatgaa cacggtctgc
     4921 ccgccatctc catgtcccac cacgccgcca gcaaattctg cgaatggctg agcgcccaga
     4981 ccgggcatta ctaccgcctg cccacggagg cggaatggga atacgcctgc cgggccggct
     5041 cccccggcgc ctattcttac ggaaacgggg aagcctctct ggaccagtac gcctggtact
     5101 ggaacaactc caatgaccgc tatcagaaaa caggctctaa aaaaccaaat aagtggggac
     5161 tccgggacat gcacggaaat gtggcggaat gggttttgga ctcttacgtt ccggatgcct
     5221 acggcaaacg gagcggcttg cccgcgaaag accccttggt catcatcccc ggcgcccctc
     5281 acatcattcg cggcggttcg tgggaagacg acccggacag cctgagaagc gctgcgcgcc
     5341 gcgccagcac ccccgcctgg aaccgtcagg atcctcaaaa ccctaaaagc atctggtacc
     5401 tgacggacgg aggcatgatc gggttccgcg tggtgcgccc catgaacatt ccggacatta
     5461 tgacgatgca ccgcctctgg aatttctcca agggggagcc gtaaagaaca acctttcatg
     5521 accattgcat taagaacgga acaatcctca gaccatgccg aaacggaaca tgtcacgaga
     5581 gaagcgttct ggaactattt cgtccccggc tgccatgaac attacctgct ccatatcatg
     5641 cgcgtcagtc cgtccttcat cccggagctg gatgcagtcg ccgtccacgg cagccgcatc
     5701 gtcgggaaac atcgttgatg caacgtccgt catcagggca gacgatggaa aagaatatga
     5761 agtgctgggc atggggccca ttgccgttct tccgaaatac cagcgccggg gaataggacg
     5821 gcgaataata tgtatgcggc ggccctccag gtctgtgagc tgcaaagggg ttccctatcc
     5881 ggcctgaaag gccgctatgt gaaagctgcc gtgtaccata tggacgaaaa gcgcgctgcc
     5941 gaatttgacg gcattttccg gtaaagaaaa agctttccgg tactgcgtct caaaaacgtt
     6001 tccagcaaat tgccgccatg ccgaaaaaac cggatacggc cccctgcccc cggaaattcc
     6061 gtaccttccg gagggcataa atcccgcata cggataagca attcttcctc tctggatata
     6121 aaaaacaaga gctgttccgc aagaacagct ctcatccgcc gatttttcgc catcaggaag
     6181 ctcaagccct gcggcggcgc atcatcagcg cggccagtcc cagcaggccc agggaaaccg
     6241 tggcgggttc cggcaccatt tcccctcgga tttccgtgaa aatcggggat aataagctga
     6301 aagtattggt tccgttggct cccgtaataa cgacagaatc accaggcgct ccctcggcgt
     6361 cataatggcc gcggatgccg ggagcagtca atccgccgct gatcgttacg gtatctcctt
     6421 ccgtgttagc agtaggggcg gctgttcccc ccgcagcata taaatacgtt ttagacgtat
     6481 cctgcatcaa gtccatcacg gactggctca cggccaggaa acggtatgtc aatgccgcgt
     6541 caagaagcag gggagaacca tccagggaag aaaaactgaa cgtcagatta atccctgctg
     6601 cagtagttcc cgtattggtg ctccagccga tgaccgaatt gtcggagcca ttcagcacca
     6661 ggaagccgta agtgacatta gcgcccaaat tgttggcggc tccgcgcagc gtaaaactgt
     6721 ccagtctgat ctctccggac agggaggagg gagaagagga atcggaagga gccagggaag
     6781 aagaccccag gccaagataa aacccatgga tggtactatt gtaattatcc gtaccgggag
     6841 tgtaataatt aaaaacggtc gctgcctccg aggaaacagc aaagcttccc atcgcgatta
     6901 aaaatgtcag tgttttcttc atatttatta ttccttttgg atggcaactt gtagcgaatt
     6961 tggaattccc caatcggatt tggaatccgt caagtaatga aaaagaggcc aaatcaatca
     7021 tgaaaccaat gaataacaaa gattgccccg tcatcttgac aaaaggacca gagatattaa
     7081 aaaatcatta ttttcaatga attataaata caatatacta actcttaata tttttaattg
     7141 cttgcggatt ccaaattcgt tattcaagcg caagtgcata cattgaatct tgcatcattt
     7201 tattaagata ctgaccatga agaaattatt atccaccctg attctttcgg ccggcatgag
     7261 cctgagcgcc accgcgaata ccactctgct ggatagctct atcgtgggat attcggactt
     7321 tacctcccaa acggcggatt tcggcaccct gaaagattcc gtttccatca cgtctgacga
     7381 cagcaatctg acgttatccg ggataacctt caacggatac ggtaccaaca accgcgacgt
     7441 tatgtctgtg acgatggttc ttgatctgtc caaaatcaac actccggaga cctataccgc
     7501 tctgtttaac gccaaaaaca gcagtgtaag ctggggcgtg ggcctgaaca cgaaccggaa
     7561 actccaggga ttatggaaca acacctcata cagcgggccc gtcgttgaca ccccgctggg
     7621 cacggaaggg tccctgacca tttccgtagt caccggagat cttggcaccc gcatctattt
     7681 tggcgacagc gctacgtact attccaacag cggcctgaaa ttcggcaacc agcaaattga
     7741 tcagattctc atggacgcag gactggctga atccatcgaa cagctctaca tccacgactc
     7801 cctcctttcc caggaacaag ttggtcaact gatgagtgaa atcgccagca ttccggaacc
     7861 cgccacggct tccctgggcc tgctgggact ggccgcgctg atgatgcgcc gccgcagggc
     7921 ataagcctgt accgtccgcc tccctatatt caaaggccgg ctcacaaaat cgtgagccgg
     7981 ccttttcctt atccgttcaa acatctgccg aaaaaacaga ggggaaaagc ttccatttgc
     8041 tgcggcaacc tcacggccag cacttgacgg aaaaatggca ttcagtctcc cccggtaggg
     8101 tcatttcaag agcttccggc cccgccccac ttccgtacac gccccttttt cccatgccgg
     8161 gacagccgga accggagcat gcaaagcccg gcttccctca gcatccggaa cagcccatcc
     8221 tttcagcaat ccatttcccc gcacggtccg gatcgctgcg gttccgtccg tcggcaacag
     8281 actccttccc cgaaacaggg aaaaggagtg ggaaaatggc tgagcttgaa cctttatccc
     8341 ccgttcccgt ccatgaacct tcaaaaacag cagctgctac tgcgcctgtt ccggtatttc
     8401 aaaagcagaa aaggagaacc gcgttttttc aacaaacgga atatatgcct tctggccgcc
     8461 gccggcgcct acatcctgac tcccgacgaa ttcctgtttg acggaatcgg caggctgggc
     8521 cttctggatg acgcggcggt catcctgggc gccgtcctca ccgtcttttt cccggacggg
     8581 gactagaggg ccgtaccctc cgccgcgccg cgggcggaac taacgggacg acactttccg
     8641 gaacttcggg gactgtccca taaatgtctc cggattttcc aggagaagac gttccgtttc
     8701 ctgccgggaa aaaccgcgcc tgcgcagctc gcaggccagg gccgtcagca ccaggggatc
     8761 ggaatccccc cagtccgctg cggaattggc ccagacacgg tccattccgt acaattccag
     8821 aatatccgcc gcccgcttgg gattcagctt gctggtggga taaagggtca gcccggccca
     8881 gtaaccggcc tccttcacca gcgggaaggt atgttcctca cagtgatcca ccagcacgcg
     8941 gcaagggtcc agatccggac ggtttttcag ggcggaaaga atcattacgg tccccttaag
     9001 cttgtcttcc agatggggag tgtgaatcag cacaagctgg ttgaggcgca ccgccagatc
     9061 cagatgctct tcaaaaatag tcatttcatg ggaagtattc cggttcagtc ctatttcccc
     9121 gatgccgagg acattgggcc ggtcaatgaa ctccggaatc agcttcatca cattccgcgc
     9181 gaaagccacg tcctgcgcct ccttgggatt gatgcacagc catgtgtaat ggtccatgcc
     9241 gaacttggcc gccctggcgg gttcgcattc cgtaagctgt acgaaataat cccggaaacc
     9301 gtccgcggac gaacggtcgt aaccggccca gaacgccggt tcccctaccg ccaggcagcc
     9361 ggcctgcgcc atggcccggt attcgtccgt ggtgcggcac accatatgta tatgaggttc
     9421 tatgaaagcc atcattctta tttgctgagg ttcggggctc cgcaggccgc tttggctgcg
     9481 gcggtttccg gcacggtgtc atccctgtag gaaagggctt ccagaatggc ccggacgcgt
     9541 ccggggccgg atgcggataa gaggggaaga acatccatca gggcatggta acggaaatcc
     9601 gcctcccctt ccccgcggtc cacccggtcc agaaatgcgg ccacatccag aacgccggcg
     9661 cgcgccgctg cgaaatccgc gtccagcact tcctttttac ttcttttcat gcacagacga
     9721 tacgcctatg cggaaagcct cgtcaagccg gaacaggcaa caaaatgata accattccaa
     9781 actgataaac agcaacctct ttccccggct tttcaaaaat ccgaaaagcg ccggaaattc
     9841 aagaagaggc ttgccatccg ggcttgaacc gggcatcctg tgaagacgca tttatttcat
     9901 tagagcgcct atgaatgcac tagtaaaaac catatgtaca ttcgtgacat cctccatcgg
     9961 ccgcaaaatc attgtggctc tgacggggtt atgtttggtc ttgttccttg cgggacacct
    10021 ggcaggcaac cttctcatct tcggaggccc tgaatggatc aacacctacg cccacggcct
    10081 gcactccatg ccggaagcag ccctctgggg aatccgcgcg gggcttgcgg tgatcttcat
    10141 catccacgtc tggctgacca tccagctgaa gctggaaaac catgcggccc gcgaacccta
    10201 cgtgttcaag aacaccatca aggcaacgct ctcctcccgc tacatgatct ataccggtct
    10261 gaccgtcctg gtgttcctga tctaccacct gtaccagtac accctgcgcg taggatacga
    10321 ccccgcccag ttcaccacct tcatttccga cggtacggtg gaaacctttg acgtgtacaa
    10381 gatgatcgtg accggatttt ccaacgtatg gtgctccgcc ttctacatcc tggccgttct
    10441 gatgctgttc agccatctgc gccacggggt acagtccatc ttccagactg tgggcgtcga
    10501 ttcccgcaaa atccggccct tctacaactt tatcgccatc gcctacggcg cgattatctg
    10561 cctgggcttc atctccgtgc cggtctcggt tcttctgggt atcatcaaat aaccatcaac
    10621 tcctctcaaa gtcatgatta attttcccgt aagcgactgg atgccggatg ccaaaattcc
    10681 ctccggccct attcaggaca aatggtccaa gtacaagctt gagtccaaac tgatcaatcc
    10741 gaacaacaag cgcaagtaca cggtgcttgt ggtaggttcc ggcctggctg gcgcctccgc
    10801 tgctgccacg cttgccgaac ttggctacaa cgtcaaatgc ttctgctacc aggacagccc
    10861 ccgccgcgcc cactccattg cggcccaggg cggcattaac gcagccaaga actaccagaa
    10921 cgacggcgac tccgtttacc gcctgtttta cgacaccgtt aaaggcggcg acttccgcgc
    10981 ccgtgaagcc aatgtctacc gtctggcgga agtctcctcc aacatcattg accagtgtgt
    11041 ggcccagggc gttcccttcg gccgtgaata cggcggcctg ctggacaacc gctccttcgg
    11101 tggcgcccag ctcaagcgaa ccttctacgc acgcggacag acgggccagc agctcctgct
    11161 gggtgcctac caggccctgg aaaaggaagt ggccaaggga cacattgaaa tgttctcccg
    11221 ccatgaaatg atggatctgg tgctggtgga cggcgaagcc aagggcatcg tcacccgcaa
    11281 tctggttacc ggcgaaatca aatcctacgc aggggatacc gtcctgctct gcacgggcgg
    11341 ctacggcaac gtgttcttcc tgtccaccaa cgcgatgggc tgcaacgtca ctgccgccta
    11401 caaggcctac aagcgcggtg ctttcttcgc caacccctgc ttcacgcaaa tccaccccac
    11461 ctgcattccg gtcaagggcg actaccagtc caaactgacg ctgatgtcgg aatccctccg
    11521 caacagcggc cgcatctggg tgcccaagtc ccgtgaaacc gcagaaaaaa tccgtaaaaa
    11581 ggaaatcaag ccttccgatg ttcccgaaga agaacgggac tactacctgg aacgcaagta
    11641 tccctccttc ggcaacctgg ccccgcgcga catttcctcc cgcgccgcca aggaagcctg
    11701 cgacgacggc cgcggcgtgg ccgtcaccgg caagggcgtc ttcctggatt ttgcggatga
    11761 aatcaagcgc atgggtcgcg aatggattga cggccaatac ggcaatctgt ttgacatgta
    11821 cgaagaaatc acggacgacg acccccatga aacgcccatg atgatctacc ccgcctccca
    11881 ctacaccatg ggcggcctgt gggtggacta caacctcatg tccaatgtga aggggctgca
    11941 cgtcctcggt gaagccaact tctccgacca cggcgccaac cgcctgggag cctccgccct
    12001 gatgcagggc ctgtctgacg gctacttcgt cattcccgcc acgctgcccg cttacctgac
    12061 gaccaccaaa cccggcgccg tcaccaccgc cgccccggaa ttcaaggctg cggaagacga
    12121 agtgaaggaa cgcatcaaca agctcctgaa tgtgaagggc accaagacgg tggactcctt
    12181 ccaccgggaa ctgggcctca ttatgtggga agactgcggc atggcccgca cggaagaaag
    12241 cctgacccac gccattgaac gcattcccca gctccgcaag gaattctggg aaaacgtgcg
    12301 cgtaaccggc acggcggacg gcatcaacgc ggaactggaa aaagcctgcc gcgtggccga
    12361 cttcctggaa ttcgcccagc tgctctgcta tgacgccctg aaccgccagg aatcctgcgg
    12421 cgcccacttc cgcgtggaat accagctgcc ggacggcgaa gctaagcgca acgacgatga
    12481 atacgcctat gtagccgcct gggaatacac tggcgtggac agcctgcctg ttctccacaa
    12541 ggaaccgctg accttcgaga acgtgcacct tgccatccgc agctacaagt aaagatagcc
    12601 aatacattaa cactcaaaag aaagattata acatggctaa aacactcaat ctcactctca
    12661 aggtctggcg ccaggaaaac cgggaagcca agggccgcat tgagacctat gccgccaagg
    12721 acattccggt ggacgcctcc ttcctggaaa tgctggacat cgtcaatgaa ggcctggtca
    12781 aggaaggcaa ggaacccatc cattttgacc acgactgccg ggaaggcatc tgtggcatgt
    12841 gctccctgac catcaacggc attccccacg ggccggaacg ccaggtgacc acttgccagc
    12901 ttcacatgcg caagttcaag gacggcgata ccgtctggat tgaacccttc cgcgcgaagg
    12961 ctttcccaat cctgcgggac ctgatggtgg accgctccgc cctggaccgc atcatcgccg
    13021 ctggaggcta tattgacgtg cgtaccggtt ccgcgccgaa cgccaacaac atcgccgtgg
    13081 aaaaagtgaa ggcggacgcc gcctttgacg cggccgcctg catcggctgc ggcgcctgcg
    13141 tggcctcctg taaaaacgcc tccgccatgc tgttcacctc cgccaagatc gcccatctca
    13201 atctgctgcc gcagggccag ccggaacgtt ccaagcgcgt cctggccatg atgaagcaga
    13261 tggaagcgga aggctttggc aactgcacga accagtatga atgtgaagcc gcctgcccga
    13321 aaggcatcag cgtggacaac atcgcccgcc tcaaccgcga cttcatgcgg gccaacgcca
    13381 aggaaggcct ctgtttctaa agaagattcc ttcttaagac gctctgtaaa aactcccggc
    13441 ggcatcggct gtcgggagtt ttttcattac caggtttcct tgaaccagga ataaaatacc
    13501 agacagttgc ttcctcatcg tcgcgcagcg taaaaaattg ttacaccgga aggcacccag
    13561 taatccagga gaccgtactt ggcaatgccg gacgaaacct aagcaggccc cgtccgacag
    13621 cgacggcccc atctttctc
//
