LOCUS       c00046_gnlPro..        18552 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MNLGOIOA_46.
ACCESSION   c00046_gnlPro..
VERSION     c00046_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 17:18:05
            Original ID  :: gnl|Prokka|MNLGOIOA_46
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 18552
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..18552
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5488:8552]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5489..8552
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..18552
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..18552
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             168..1529
                     /locus_tag="ctg46_1"
                     /transl_table=11
                     /translation="MIHMTLRKKTLWFLGALSFFASLAAAFAVFWLNRNDSSPAEWNFN
                     PIWTKAEKEQILTAANFTAHRSPERFIYRGLSLNSRHIDWHMFSEVSMRQYMKDEIRER
                     LQMIRDTAESADGRCITPSHETLLHLAAGLGEVQLLNRLLQRHADPNVQIILPQQAFPS
                     IPDSEQGNTPLTYACQPGMDDSTPLPVHNRLSCLNLLIQYGADVNKPGPLGWPPLIITC
                     VAGIGGAPYEEAALFLLKCGADISLQPELKGKKTSLLTWAAAAGYPLLVRKLCEAGYDP
                     NFRGEMAPPLLSLNLNTPNAALQIAHILLEYGADVNAAMPASTTLPETAGDTALLNLCR
                     QLAFIDVSCLPQIRDLVNLFIKEGADVNHQNAAGETPLMACCRGMLLGDDSLDRLKLGI
                     ARLLLDHHANPSLKDKYGRTALQRIGNRSNEHLQMVLKYLPELSAPPLPKKENH"
     CDS             complement(1543..3330)
                     /locus_tag="ctg46_2"
                     /transl_table=11
                     /translation="MKNLLFALLTGSFCCCYAQQKAAPVPEPEVVATPPADAGRGLIRV
                     DSREIRHYSGTRKEPDYLVSRDNGKTWEMKAAPAGYPPNYGGIPKESPAIVRNPLTREF
                     IRVQPIGGFVFLSRGGLDGKWLAVTNDGKLEEDWKDPEKRKNLKKLGGIMRTPVFVNKG
                     RRVIVPFHNMGGGTKFHISDDGGLTWHVSRNGVTSPRHEARPPHQGVRWFNNAVEATVL
                     EMKDGTLWALARTSQDQAWQAFSKDYGETWSKPEPSRFFGTLTMNTLGRLDDGTIVSLW
                     TNTMALPENATAGNGTWEDVFTNRDSHHIAMSGDEGKTWYGFREIILDEHRNHPGYATL
                     DGPEDRGKHQSEMVQLDKNRILISLGQHKNHRRLVIVDRRWVGAKTRATQTGKDLDSQW
                     TIHTYIPQKKGHCSYNRKPSAELVQDPSGGTKKVLQIKRLDDPELVNEKSNVDYRNGGA
                     TWNFPNGTTGLVKFRFRVADGEQADDSGLQVSLTDRLFNACDSTTKDYALFTFPIRLRP
                     APHLLLGMKKVPFSPGAWHEISLLWQGGQAVVSLDGKKAGTLKMANKSPNGVSYIHFIS
                     TGSQPDAGILLDTVNARVK"
     CDS             complement(3415..4203)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lipase_GDSL_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_3"
                     /sec_met_domain="Lipase_GDSL_2 (E-value: 7.2e-24, bitscore:
                     74.7, seeds: 1564, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFLSYMLAILLGSSSLAFSAPSIPASALPATLKPEPHQRDPYDW
                     NARHEAVKKRNRAVKPEYVMIGDSITHHWGGEPSGDGKNTGSGSWEKLFGPHAATNMGF
                     GFDYVDNAYYRVQNGELDGISPRVIIVLLGTNNLGHRKDTPQACADNIRAFVRLVRRKC
                     PSSKILLLGVLPRKEKNLAEPVKQTNRLLAELHNGKDIFFADPGKALLSADGASPQNEF
                     MKDVVHPNARGYEVLEKELAVLLKKLDAKYRGGKQAGKHS"
     CDS             complement(4426..5208)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lipase_GDSL_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_4"
                     /sec_met_domain="Lipase_GDSL_2 (E-value: 4.2e-24, bitscore:
                     75.4, seeds: 1564, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYACLCLLLAGVFCVACFSGACADELPPTLKPQVNPRAVYDWK
                     KRHEAVMERNRTVKPEYVVFGDSITHRWGGEPSGDNRALGTGKTAWHSLFSSHAVTNMG
                     FGSDYVDNAYYRLQLGELDGISPRVIIVLLGTNNLGGRKDAPRACADNLKAFVSLARRK
                     CPSSKILLLGILPREGKKLAPLIRETNKMISGLADGNSVFFANPGEEFLGEDGVSPKPG
                     LLEDGLHPSARGYDILGKSLSVLLKKMDDKYGKLPAPR"
     CDS             5489..7756
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_5"
                     /sec_met_domain="Gly_radical (E-value: 1.3e-45, bitscore:
                     144.0, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 5.4e-282, bitscore:
                     926.0, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISIVKDLKESTALPQEWQGFKPGTWTESIDVRDFIQHNYTPYSG
                     NEEFLSGPSQRTLRLWDELKVLLKREIDNGGVLDADEEVVSSITSHKPGYIDKELEVVV
                     GLQTDAPLKRALMPFGGLRMAQQALESYGFKMCEKTADIFKKIRKTHNEGVFDAYTSDI
                     RAARSAGIITGLPDAYGRGRIIGDYRRVALYGTDKLIAERRKDLKNREHSPLTDELIRL
                     REEMSEQIRALEELAQLGASYGCDLTRPAANAREAVQWTYLGYLAAVKEQNGAAMSLGR
                     VSTFFDIYFTRDLEQGLITEEEVQEIIDQFVMKLRIVRFIRTPDYNNLFSGDPTWVTES
                     IGGMGEDGRTLVTRSSFRMLQTLYNLGPAPEPNLTVLWSRNLPEAFKSFCAKVSIETSS
                     VQYENDDLMRPHWGDDYGIACCVSAMRIGKQMQFFGARANLAKCLLYALNGGVDELKGK
                     QVAPPSPRYTEEILNYDEVMALYDKMQDWLAKTYIDALNIIHYMHDKYCYERIEMALHD
                     PEILRTMATGIAGLSVAADSLSAIKYATVKAIRNEEGLIVDFKTEGEFPCYGNNDPRVD
                     DIACSLVSNFMEKLRRLHTYRNSLPTQSILTITSNVVYGKKTGNTPDGRRAGEPFAPGA
                     NPMHGRDRNGAVASMLSVAKLSYDDSLDGISYTFSIVPQALGKEERERRVKLVSLLDAY
                     FAATGHHINVNVLERKTLLDAMDHPEKYPQLTIRVSGYAVNFIKLTREQQQEVINRTFH
                     TR"
     CDS             7773..8552
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 53.7;
                     E-value: 9e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_6"
                     /sec_met_domain="Radical_SAM (E-value: 1.5e-31, bitscore:
                     99.6, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQVFPQNHDPDGESSVTGLVHSVESCGTVDGPGIRFVLFLSGCS
                     LRCRYCHNPDTSYVRRGRLRSADDVLKEIARYRDFLQAAGGGVTLSGGDPLFQPDFAGA
                     VLKGCRKLGLHTCLDTSGHLGVNAGEEMLADTDLVLLDIKAWNPKRYRALTGGELHPTL
                     EFAERLASLRKPVWLRYVLVPGVTDNLEEIEELSRHAALLGNVERVDVLPFHQLGRFKW
                     DELKLDYTLKDVPEASAELAEQVRGIFRQGGFPDCVH"
     CDS             complement(8801..10726)
                     /locus_tag="ctg46_7"
                     /transl_table=11
                     /translation="MTDSSSPDSSPASRNTFAHHLGMKGFLLMEGLLKLVGMKTLYRLG
                     RAAGAVAWHLLPQRRNIVERNLRIVLDPALRGKELQKLSRENFKRTIANFLCSAKTATL
                     TDEQLKHCVTVGGHEQFAAPVLEGRGQVCAIAHSGNWEALARIRAFYPEVERYGSMYRQ
                     FDNPLMEEYVYQRRTERGTQMFSKEGGIKAPMKMLKEGGALGVLSDQFVWEGVYVPFFG
                     KVTGTTPLPALLRKRAGADMVAIAVRTDAPGHWIADMGNVVDFSRSDGSLAGDTIEVNR
                     GLETLIRESVLDVFWMHHRWKSVDRFAPQDKKTAALLENMELKPYRILVAVPRALDEAL
                     ATVPLIRALKTVRCDMQVNIVCPSAQLGIWKTVPEVTHVLPHDSLKQLREALAADEFYN
                     DGPLDLGVMLDGDMETLKALEPYGPMMFSGLDTHPGARKYKFRVKAPVLRAAPPAHRVQ
                     LYLQLGGLHGLDAATPSLFPVKKAAPAEDAPILIAPFSRLGSASEWSWEQWRELVSLLP
                     GRTVLAALEEDRERAASLAEHLNVELAVGAPEALFPVMDGAAAAVAVDGDLPSLCSFRG
                     LPVVTLFSTRLPDVYRPMGTFNRSLYSHQCCSPCFRKECDRDVPCNRHIAVRDVLEALR
                     EISGKE"
     CDS             10876..11178
                     /locus_tag="ctg46_8"
                     /transl_table=11
                     /translation="MLYCIFLIKASLRRRHLTFGKEMTLQFLTKRYISSPEPNTKPELY
                     TMKVLSSLASMKRRHADCQIVKRKGTLYVICKSNPKFKARQGATAGTRLSKKGVK"
     CDS             11265..12428
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_9"
                     /sec_met_domain="Abhydrolase_1 (E-value: 4e-30, bitscore:
                     94.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLPAVQTKFLDLPNSFSLRNGATLDKVRVAYEQYGTLTPNKDNA
                     ILLFHALSGSQHAYGYNPEVPGIGSLWKPENHEGWWNSIIGPGKPLDTNRFCIICANYL
                     GGCYGTTGPATPCPADGQPYGSRFPHVEAADQARLQALLLDSLGIERVHLMGPSVGGLI
                     ALSFACQFPERVRSFISIGSGYRASIEHRLSLFEQILAIELDPDFQGGDYYRGLAPKKG
                     LAFARIIGHKSFVYQEGLEQRARKEVGGNYGLLTWMTPTRSTQSYMLHQGTKFAERFDA
                     NAYIRIADMWAEFDIRDHTPDGTFQTALEGFRRAGIPALIFSIDTDCCFRPAEQQDFAA
                     QLEAAHIPTEFHTIASTKGHDSFLLEPELYAEPIRRILEARKPKGTA"
     CDS             12627..13037
                     /locus_tag="ctg46_10"
                     /transl_table=11
                     /translation="MTDHYYTSETENVGQFRCETTFIPSNVTFATDLPASFEGRAEFPS
                     PGVLLGSTLASCMMSLVSVVAARKGVDLKGMRVLARAAESSKGIEKIELKAIMPLEGSH
                     PLRAMLEKTALSCPVRQALRPDLETPIEWEWK"
ORIGIN
        1 ccacgagctt ttttcccaga tgaagaggaa aaaaattctc ctccgaattt gcaatccgcc
       61 acccgaattc ccacatggtt tgccccgggc attctttgct catactattt tttcattgcc
      121 cggagttatg gattcctgca tcatggcctt tcgcagtacc cctgcttatg atacacatga
      181 ctttaagaaa gaaaactctc tggtttcttg gagctttgag cttttttgcc tctcttgccg
      241 cggctttcgc tgttttctgg ctgaacagga atgattcttc tcccgcagaa tggaatttca
      301 accctatctg gacaaaagcg gaaaaagaac aaattcttac cgcagcgaat ttcacagccc
      361 atcgaagccc ggaacgtttc atttaccgcg ggctttccct caattcacgc catattgact
      421 ggcacatgtt ttccgaggtt tccatgcgcc aatatatgaa ggacgaaatc agggaacggc
      481 ttcagatgat acgggacacg gcggaaagcg cagacggacg ctgcatcact ccatcccatg
      541 aaaccctgct gcatctcgcc gccgggctcg gagaagtgca gttgctgaac cgccttttac
      601 agcgccatgc ggacccgaac gtccagatca tcctgccgca acaggccttt ccctccattc
      661 cggactccga acagggaaat acccccctga cttacgcctg ccagccaggc atggacgact
      721 ccacgcccct gccggtgcat aacaggctct cctgccttaa tctcctgatt cagtacggtg
      781 cggatgtgaa taaaccgggg ccgctgggct ggccgcccct catcatcacc tgtgtagccg
      841 gtattggagg agcaccctat gaggaagcgg ccctgtttct tctgaaatgc ggtgcggata
      901 tttccctcca gcctgaattg aaaggtaaaa aaacaagtct gctcacatgg gccgcggccg
      961 ccggataccc cctgctggtc cgcaagcttt gcgaagccgg gtacgatccc aatttccgcg
     1021 gggaaatggc cccgcccctt ctttccctga acctgaacac tccgaacgcc gcactgcaaa
     1081 ttgcacatat tctgctggaa tacggagcgg acgtgaatgc ggccatgccc gcgtccacca
     1141 ccctgccgga aacagcggga gacacggccc tgctaaacct gtgccgccag ctggctttca
     1201 ttgatgtgtc ctgcctccct caaatcaggg atctggtcaa tctcttcatc aaagagggag
     1261 ctgacgtcaa ccatcaaaac gccgccggag aaactcccct catggcatgc tgccgaggca
     1321 tgctgctggg agacgattcc ctggaccggc tgaaactggg tattgcgcgt cttctgctgg
     1381 accaccacgc aaacccatcc ctgaaagaca aatacggacg cacagccctc cagaggatag
     1441 gcaaccggtc aaacgaacat ctccagatgg tgctgaaata cctgccggaa ttaagcgctc
     1501 cgccgcttcc gaagaaggaa aaccattgaa tcccgccgat ccttacttca cccgggcatt
     1561 caccgtatcc agcagaatgc cggcatccgg ttgggacccg gtgctgatga aatggatata
     1621 actgactcca ttaggggact tattagccat tttcaacgtt ccggccttct ttccgtccag
     1681 agacaccacg gcctgcccac cctgccaaag aagggaaatt tcatgccacg cgccgggcga
     1741 gaaaggcact tttttcatcc ccagcaacag atggggcgca ggtctcagcc tgatcgggaa
     1801 ggtaaacagg gcataatcct tcgtagtgga atcacaggca ttgaacagcc ggtccgtcag
     1861 agagacctga aggccggaat catccgcctg ctccccgtcc gctacacgga agcggaattt
     1921 gaccaacccc gtggtcccgt tcggaaagtt ccaggtagct ccgccgttcc ggtaatccac
     1981 attggatttt tcattgacca gttcgggatc atccagacgc ttgatttgca acaccttctt
     2041 cgtgcccccg gacggatcct gaaccagctc ggcggaaggc ttgcggttat aactgcaatg
     2101 gccttttttc tgggggatat aagtgtgaat ggtccactgg gaatccaaat ctttccccgt
     2161 ctgcgtggca cgcgtcttgg cccctaccca gcggcggtcc acaataacca ggcggcggtg
     2221 gtttttatgc tgccccaggg aaataaggat gcggtttttg tccagctgca ccatttcgct
     2281 ctggtgtttg ccgcggtctt ccggaccatc cagcgtagca tagccgggat ggttgcggtg
     2341 ttcgtccagg ataatctccc ggaacccgta ccaggttttg ccctcgtccc cggacatagc
     2401 aatgtggtgg gaatcacggt tggtgaatac atcctcccac gttccgttgc cagctgtggc
     2461 attttcaggc agagccattg tattcgtcca cagggaaacg atagttccgt catccaggcg
     2521 tcccaacgtg ttcatggtca gggtgccgaa aaagcgggaa ggctccggtt tgctccacgt
     2581 ttccccgtaa tccttggaaa aagcctgcca cgcctggtcc tgggaggtgc gggcaagcgc
     2641 ccacaacgta ccgtctttca tttccaaaac cgtggcttcc acggcattgt tgaaccatct
     2701 gacgccctgg tgggggggcc tggcttcatg tctgggggaa gtaacaccgt tcctggatac
     2761 atgccaggtc agccccccgt catcggaaat atggaacttg gtgccgccgc ccatgttgtg
     2821 gaacggcacg atcaccctgc ggcccttgtt cacaaaaacg ggggtccgca tgatgccgcc
     2881 cagttttttc aggtttttcc tcttttccgg gtctttccag tcttcttcca gtttgccgtc
     2941 attcgtgacg gcaagccact tgccgtccag cccacccctg gaaagaaata caaagccccc
     3001 gataggctgc acacgaatga attccctggt cagagggttg cgcacaatag ccggagattc
     3061 tttgggaatg ccaccgtagt tgggagggta gccagccgga gcggccttca tttcccatgt
     3121 ttttccgtta tccctgctga ccaggtaatc cggttccttg cgggtaccgg aataatggcg
     3181 tatttcacgg gagtccacac ggataaggcc gcgccccgca tcagccggcg gagtggcgac
     3241 aacttcaggt tccggaacgg gtgcggcctt ctgttgggca taacagcaac aaaaggaacc
     3301 ggtcaacaat gcaaacaaca ggtttttcat aaactaaata tcaaaggccg tatattttcc
     3361 tcaaccgggg ctttcccttc aagcaaaatc ctaccttcca tcagaagacg atcatcagga
     3421 atgctttccc gcctgcttcc ctccccggta ttttgcatca agctttttca ggagtacggc
     3481 cagttccttt tccaaaacct cgtaccccct ggcattggga tgcaccacat ccttcatgaa
     3541 ttcattctgc ggagaagcac catctgcgga aagaagcgcc tttcccggat cggcaaagaa
     3601 aatgtccttt ccgttatgca gttccgccaa cagtctgttc gtctgcttca ccggttccgc
     3661 caggtttttc tccttccgtg ggagaacgcc cagcaacagg attttggaag aggggcactt
     3721 ccggcgcact aggcggacaa atgccctgat attgtccgca catgcctgcg gcgtatcctt
     3781 gcggtgcccc agattattgg tccccagcaa cacaatgatg acccgcggag aaatgccgtc
     3841 cagctccccg ttttggacac ggtaataggc attatccaca taatcaaatc caaagcccat
     3901 attcgtcgct gcatgcggac cgaataattt ctcccaggac cccgatcccg tattttttcc
     3961 gtccccggaa ggctcccctc cccaatggtg ggtaatgctg tcccctatca tcacgtattc
     4021 aggcttgacg gcccggtttc tttttttaac ggcttcatgc cgggcattcc aatcatacgg
     4081 gtcccgctga tggggctccg gcttcagggt agcgggcaac gcggaggccg gaatggaagg
     4141 cgcagaaaat gccagactgg aactccccag caatatggcg agcatgtagg agaggaaatt
     4201 cataatcaaa aagtaaaacc ggttttcagt ttaagcaaat tctgccgtgc atcaagatcg
     4261 caggcgtcac ttcctccggc agagtaaaaa agaccactgc ccgtccggca aatcctgccg
     4321 caaccacggc caggcgagca ccgtgtccgg cctcttccaa ggcgcgctcc atttcatcca
     4381 tcccccggcc tctcccggaa caggaacgcc ctcccccgta ttcatctacc ggggagcggg
     4441 cagcttgccg tacttgtcgt ccattttctt cagcaatacg ctcaacgact tccccagtat
     4501 gtcgtacccc ctggcactgg gatgcagccc atcctccagc agcccgggtt ttggggacac
     4561 tccgtcctcc cccaggaatt cctcgccggg attggcgaaa aacacgctgt ttccgtcagc
     4621 caggccggat atcattttat tggtttccct aatcagggga gccagctttt ttccctccct
     4681 ggggagaatg cccagcaaca ggattttgga agagggacac ttccggcgcg ccaggctcac
     4741 aaaagccttg agattgtctg cgcaggcccg gggagcatcc ttccgcccgc caagattatt
     4801 ggttcccagc agcacgatga tgacccgcgg agaaatgccg tccagctctc ccagctgcaa
     4861 gcggtaatag gcattatcca cgtaatcgga accaaacccc atattggtta ccgcatggga
     4921 agaaaacagg ctatgccagg cggtttttcc tgttccgaga gccctgttgt ccccggaagg
     4981 ctcgccgccc cagcggtggg taatgctgtc accaaagacg acatattccg gtttgacggt
     5041 ccggttccgc tccatcactg cttcatgacg ttttttccag tcatacacgg cccgcgggtt
     5101 cacctggggc ttcagcgtgg gcggcaattc atcagcacag gcaccggaga aacaagcaac
     5161 gcaaaaaact cccgccagca ataaacaaag gcatgcataa gatttcataa cggtaagcgt
     5221 tgagatactg caatagagat taggaaagta aagagaaata atcttccgtc acttttccgc
     5281 aatcgcatgt tcccctcatt ttccgctccg caacggacag acaggtgaaa catgccaaag
     5341 ccagcgcacc cgcgttctct tcgcaaagaa ttagccttgt tgtcccccgg aattcacgat
     5401 ataattacgc ggcgcggagt tttgccgttt ccagcctttc aggggctgcg gaacgttttt
     5461 ctccagtctt cttcactaca ttctatttat gatcagcata gtaaaagact tgaaggagtc
     5521 caccgccctt ccgcaggaat ggcagggatt caagccggga acatggacgg agtccattga
     5581 cgtacgggat ttcatccagc ataactacac gccctattcc ggcaatgaag agtttctttc
     5641 cggcccctcc cagcgcacgc ttcgtttatg ggacgagctg aaagtcctgc tgaaacggga
     5701 aatagacaac ggcggcgtgc tggatgctga tgaagaagtg gtatcctcca tcacatccca
     5761 caagcccggc tacattgaca aggaactgga agtggtcgta ggcctccaga cggacgcccc
     5821 cctgaaacgg gccctgatgc cctttggcgg cttgcgcatg gcccaacagg ccctggaatc
     5881 ctacgggttc aagatgtgcg agaaaaccgc agacattttc aaaaagatac gcaagacgca
     5941 caatgaaggc gttttcgacg cctacacttc cgatatccgg gcggcccgtt ccgccgggat
     6001 tattaccggc cttccggacg cctatggccg cggccgcatc atcggggact accgccgggt
     6061 ggccctgtac ggcacggata agctgattgc cgaacgccgc aaggacctca aaaaccgtga
     6121 acattccccc cttacggatg agctgatccg tctgcgcgaa gaaatgagcg aacaaatacg
     6181 cgccctggaa gaactcgccc agctgggcgc ctcctacggc tgcgacctca ctcgccccgc
     6241 cgcaaacgcc cgcgaagccg tgcaatggac gtacctgggc tacctagccg ccgtgaagga
     6301 acagaatgga gcggccatgt ccctgggccg cgtttccact ttcttcgaca tttatttcac
     6361 ccgcgacctg gaacaggggc tcatcacgga agaggaagtt caggaaatca tcgaccagtt
     6421 cgtgatgaag ctgcgcatcg tccgtttcat ccgcacgcct gattacaata acctgttctc
     6481 cggagacccc acctgggtga cggaatccat cggcggcatg ggagaggacg ggcgcaccct
     6541 cgtcacccgc agttccttcc gcatgctgca gaccctgtac aacctggggc cggctccgga
     6601 accgaacctg accgttctgt ggtcccggaa cctgccggaa gccttcaaaa gcttctgcgc
     6661 caaggtttcc attgaaacgt cctccgtcca atacgagaac gacgacctga tgcgcccgca
     6721 ttggggcgac gactacggca tcgcatgctg cgtgtccgcc atgcgcatcg gcaagcagat
     6781 gcagttcttc ggagcgcgcg ccaacctcgc caagtgcctt ctctacgccc tgaacggcgg
     6841 cgtggatgaa ctcaagggca agcaggtggc cccgccctcc ccccgctaca cggaggaaat
     6901 tctcaactat gatgaggtga tggccctgta cgacaagatg caggactggc tcgccaaaac
     6961 ttacattgac gcgctgaaca tcatccacta catgcacgac aaatactgct atgaacgcat
     7021 tgaaatggcg ctgcatgatc cggaaattct gcgcacgatg gctacgggaa tcgccgggct
     7081 ttccgtggcg gcggactccc tgtccgccat caagtatgcc accgtaaaag ccatccgcaa
     7141 tgaagaaggg ctgattgtgg acttcaagac ggaaggggaa ttcccctgtt acgggaacaa
     7201 tgacccgcgc gtggacgaca tagcatgcag cctggtcagc aatttcatgg aaaaactgcg
     7261 caggctccac acttaccgca attccctgcc cacccagtcc atcctgacga tcacctccaa
     7321 cgtggtgtac ggcaaaaaga cgggcaacac gccggacggc cgccgagccg gggaaccgtt
     7381 cgcccccgga gccaacccca tgcacggaag ggacaggaac ggagccgtgg cctccatgct
     7441 ctccgtagcc aagctgtcct atgacgactc cctggacggc atctcctaca ccttctccat
     7501 cgttcctcag gccctgggca aggaagaacg tgaacgccgc gtcaagctcg tctccctgct
     7561 ggacgcctac tttgccgcta caggtcacca cattaatgtg aacgtactgg aacggaaaac
     7621 gcttctcgac gccatggatc acccggaaaa atacccgcag cttaccatcc gcgtttccgg
     7681 ctatgccgtg aatttcatca agctgacccg ggaacagcag caggaggtca tcaaccgcac
     7741 tttccacacc cgttaacccg gactgcaagc ggatgccgca ggtttttcca caaaaccatg
     7801 atccggacgg agaaagctcc gtcaccggtt tggttcattc cgtggaatcc tgcggcaccg
     7861 tggacggccc cggcatccgc ttcgtccttt tcctgtccgg ttgcagcctg cgctgccgct
     7921 actgccataa tccggatacc tcctacgtgc ggaggggccg gctcaggagc gcagatgatg
     7981 tcctcaagga aatagcccgt taccgggatt ttttgcaggc ggcgggcggc ggcgtcaccc
     8041 tctccggcgg ggaccccctc ttccagccgg attttgccgg tgccgtgctg aaaggctgcc
     8101 ggaaactggg cctgcacacc tgcctggaca cctccggcca tctgggcgtg aatgcgggcg
     8161 aagaaatgct ggcggatacg gatctggtcc tgctggatat caaggcatgg aatccgaaac
     8221 ggtatcgcgc cctgacaggc ggggaactgc accctacact ggagtttgcg gaacgcctgg
     8281 cctccctccg caagcccgtg tggctgaggt atgtgctggt acctggcgtt acggacaatc
     8341 tggaagaaat tgaggaactc tcccgccatg cggcgcttct gggcaacgtg gaacgcgtgg
     8401 acgtgctccc tttccaccag ctggggagat tcaaatggga tgaattgaag ctggactata
     8461 ccttgaagga cgtcccggaa gcgtccgcag aactggcgga acaggtccgc ggcattttcc
     8521 ggcagggcgg ctttccggat tgcgtgcatt aaccggattt tcgcgctttg gcgccaccaa
     8581 ccgcagcaaa ccggacgcag gcatccccct cttccggatg aggggccctc tcccctccac
     8641 tgcagaatcc atgcaaaaag gaagacgcat ttctggaatt gctccggaat acggcatttc
     8701 cgcaattcct ttcgttattt catcattctt tacggcaacg gcagcattcc cgccgttttt
     8761 tccgccaacg ccgggggacg gcattccgtc ccttcccaga ttattctttc ccggaaattt
     8821 cccgcaaggc ttccagtacg tcccgcacgg caatgtggcg gttgcaggga acatcccggt
     8881 cacattcctt ccggaagcag ggagaacagc actggtggct gtaaagggaa cggttgaatg
     8941 tgcccatagg gcggtaaaca tccggaagcc gggtggaaaa cagagtcacc accggaagcc
     9001 cccggaaaga acagagggac ggcaagtcgc catccacggc tactgccgcc gcagcgccgt
     9061 ccatgacggg aaagagagct tccggcgcac ccaccgccag ctccacattc aaatgttccg
     9121 ccagggacgc ggcgcgctcc cggtcttctt ccagagccgc cagcaccgtc cgtcccggca
     9181 gaagggaaac cagctccctc cactgctccc agctccattc actggcgctc cccaggcggg
     9241 aaaacggagc gattaaaatg ggggcatctt ccgccggggc cgcttttttc acagggaaca
     9301 aagacggggt ggcggcgtcc agcccatgca gcccccccaa ttgcagataa agctgcaccc
     9361 ggtgcgccgg gggggcggcg cgcaggacgg gggcctttac ccggaacttg tacttccggg
     9421 caccgggatg cgtgtccagc ccggaaaaca tcatggggcc atacggttcc agcgctttca
     9481 gggtttccat atctccatcc agcatgacgc ccagatccag cggtccgtca ttgtaaaatt
     9541 catctgctgc caaagcttcc cgaagctgct tcagggagtc gtgcggcagc acatgggtga
     9601 cttccggcac cgtcttccat atccccagct gggcagacgg gcagacgatg ttcacctgca
     9661 tgtcgcaccg gacggttttc aaagctcgaa tcaggggaac agtcgccagg gcttcatcca
     9721 gcgccctggg aacggctacc agaatgcggt acggcttcag ctccatattt tccaggagcg
     9781 cagccgtttt tttatcctgc ggggcaaatc ggtcaacgga tttccagcga tggtgcatcc
     9841 agaacacatc cagcacggat tcccggatca atgtttccag ccccctgttc acttcaatcg
     9901 tgtcccccgc cagagagccg tccgacctgg aaaaatccac cacattcccc atatccgcta
     9961 tccagtggcc gggagcatcc gtgcgcaccg ctatggccac catgtccgcg ccagcccttt
    10021 ttctcagcag agcgggcagc ggagtcgtgc cggtcacctt gccgaaaaag gggacataca
    10081 ccccctccca tacgaactgg tcgctcagca cgcccagggc tcccccttcc ttgagcattt
    10141 tcatgggagc cttgatgcct ccctccttgg agaacatctg agttccacgt tccgtgcgcc
    10201 gctggtacac gtattcctcc atcagcggat tgtcaaactg gcggtacatg gacccgtaac
    10261 gctccacctc cgggtaaaat gcgcgtattc tcgccagcgc ctcccagttg ccggagtggg
    10321 ctatggcgca aacctgcccg cgcccttcca gcacaggcgc ggcaaactgt tcgtgccctc
    10381 cgaccgtcac gcaatgcttc aactgctcat ccgtcagggt ggccgtcttc gcggaacaca
    10441 aaaaattggc aatggtcctt ttgaaatttt cccggcttaa tttctgcagt tcctttccgc
    10501 gcagggccgg atccaaaacg atgcgcagat tcctttccac aatgttccgg cgctggggaa
    10561 gcagatgcca cgccacggcc cctgccgcgc gccccagccg gtacagcgtt ttcatgccca
    10621 cgagcttcaa cagcccttcc atgagcagaa accctttcat tcccaaatga tgggcaaacg
    10681 tattccggga agccggggag gaatcaggag aggaagaatc agtcataagg aaaaccggaa
    10741 aagatgttat acgaatcccc tccggtccac aaacccttta ttcccccggc agagatccct
    10801 tcccgcattt tattttcccg gctaaatgac gtcttcccta aatttttccg ccggcgcgga
    10861 atccaaagcc atcccatgct ttactgcatc ttcctcataa aagcatctct gcggagacgg
    10921 catcttactt ttggcaaaga aatgacttta caattcttaa ctaaacggta tatttcgtct
    10981 cccgaaccga acaccaaacc ggagttatac accatgaaag ttctttcttc cttagcctct
    11041 atgaagcgcc gccacgcaga ctgccaaatc gtgaagcgca agggcacgct gtatgtgatc
    11101 tgcaagagca atcccaagtt caaggcccgc cagggcgcta cggcaggcac gcgcctttcc
    11161 aaaaagggcg ttaagtaatc cctggcccag cacagatttc aagaagaccg ccgcccgccg
    11221 ggtgccggtc tttttttgct gaccaagccc ctttccgtac atccatgcag cttcctgccg
    11281 tccaaaccaa attcctggat cttcccaact ccttctccct gagaaatgga gctacgctgg
    11341 acaaggttcg cgtcgcctac gaacaatacg gaaccctgac gccgaataaa gacaacgcca
    11401 tcctgctgtt ccatgctctt tccggcagcc agcacgccta cggttacaat ccggaagtcc
    11461 cgggcatcgg ttccctctgg aaaccggaaa accacgaggg ctggtggaac agcatcatcg
    11521 gccccggcaa gccgctggac acaaaccgct tctgcatcat ctgcgccaat tacctgggag
    11581 gctgctacgg caccacaggc cccgctaccc cctgccctgc ggacggccag ccctacggct
    11641 cccgcttccc gcatgtggag gccgcagacc aggcacgtct ccaggccctt ctgctggaca
    11701 gcctgggcat agaacgcgtt catcttatgg gcccctccgt gggcggcctg atcgccctca
    11761 gcttcgcgtg ccagttcccg gaacgggtcc ggagcttcat ctccatcggc tccggttacc
    11821 gggcttccat cgaacaccgc ctgtccctgt ttgaacaaat cctggccatt gagcttgacc
    11881 cggatttcca aggcggggat tactaccggg gactggcgcc caaaaaaggg ctggcgttcg
    11941 cccgtatcat cggccacaaa tcatttgttt accaggaggg gctggaacag cgcgccagaa
    12001 aagaggtggg aggcaactac ggcctgctca cgtggatgac ccccacccgc agcacgcaaa
    12061 gctacatgct tcaccaggga accaagttcg cggagcgctt tgacgccaac gcctatatcc
    12121 gtattgcgga tatgtgggcg gagttcgaca tccgcgacca caccccggac ggaacatttc
    12181 aaactgccct ggaaggcttc cgccgcgcag ggattcccgc gcttatcttt tccattgata
    12241 cagactgctg tttccgcccg gcggaacagc aggatttcgc ggcgcagctt gaagccgccc
    12301 atattcccac ggagttccat accatcgctt ccaccaaggg acacgattcc ttcctgctgg
    12361 agccggaact ttatgcggaa cccatccggc gcattctgga ggcaaggaag ccgaagggga
    12421 cggcgtaagc tttttcccgc cgcaagaaga cacggcggag caacgcttaa aaagaagtga
    12481 tgccgggaac cggaagcaag agggaaaaat caaccatgtc atgaaggaac ggccaggttc
    12541 cctgcaaagc ggaacttcac ggctcttcaa cgtgaaaata acctgaaccg gatgaacccg
    12601 aacagggttt tcgctgtcac accttcatga ctgatcatta ttacacctcc gaaacggaga
    12661 acgtcggaca attccgctgc gaaaccacct ttattccttc caacgttacg tttgccacgg
    12721 acctgcccgc ttcttttgaa ggccgcgcag aattcccctc ccccggagtt ttgctcggtt
    12781 ccacgctcgc ctcctgcatg atgagcctgg tttccgtggt cgcggccaga aaaggagtgg
    12841 atttgaaagg catgcgcgtt ctggcgcgtg cggcggaatc atccaaggga attgaaaaaa
    12901 ttgaactgaa ggcaatcatg cccctggaag gcagccaccc tctccgcgcc atgctggaaa
    12961 aaaccgcctt gtcctgccct gtgcgccagg cgctgcggcc tgatctggaa acgcccattg
    13021 aatgggaatg gaagtaagca gccatcaggg acgtcaaccc aagcttgaag ttatccttaa
    13081 agaaatcccg cccattcatg aaaaaagccg ctgcggaatc atccgcagcg gctttccaat
    13141 tggccgacgt tttttccttt agaagttgta gcggtagccg atactcccgt tgatggagct
    13201 ggagccgctg cggatatccg cgttgccgtc cacaaaaatg acgccctggg tgcccacggg
    13261 aacgctcagc cccgcgccaa tctggaaggc cgtgcttccg accttggcgc catacaccgg
    13321 acgcgtatag gagggatctg ccaggaagcc cacattagcc tgcccgcggc ggtctcccat
    13381 atcctgggaa acgttcaccc gtacttctcc cagcgcttca cgcccgaaga tattggaccc
    13441 cataagtccg gagagccggg cacccacagc gacagcagcc gtagtcagtt cctggtcttc
    13501 caccttcagt ccggcatttc cggcagaacc gctttcccga tagccgtcca tgcgggtcgt
    13561 cacgatggaa gcgttaaaca aaggctggag aatcacgctc ctgtcttcat tgagagcgat
    13621 gtcatacgcc aactcgtaca tggcgccgaa accggctccc gtcgtattgc cgcgggcctg
    13681 gtaagacccc gtaccgtaat tcaccgtgcg cgtcagcgag gcatcattcc agccgcccgt
    13741 cagaatcagc agatgggacc atttacggta ctggtagcgg gcgaacagat tgacatagta
    13801 actgtccagg tctccgtccg ccgtatccgc cgcgctggcc gtcaggcttc cgtaattggc
    13861 tgtaaacgca gctcccgcag tgaggcggtc gttgatatcc acgtccatgc ctaccgtgcc
    13921 tccccaggtg gtgagttcgt agccgctttc atcccccctg gtgtccagct tggcataaga
    13981 cccggttccc tgcatccaca tatggaagta gggcatgtct tcatggacat atgcagggtt
    14041 aacgcccatc tgcgccacgc ggttgcgtat ccagcccatc tggtcgcgca gggagtcgcg
    14101 ctgggcgatg cccaggctgg taaccgtgct gccggcggcg gcggccagtt tgcgggcggc
    14161 gccggaatag tcgcctgaat tctgggaaag aagaacagaa gtatagaaat cgcgcaaggc
    14221 agagccttcc tccatgtgat agcgggaatt ccaaaggatg tccgctccag tggcggcatt
    14281 ccgcgtcagg gaagagtcac ggaaaatgtt ttccgtgcgc gccgtaccgg tgaggatgat
    14341 ggccgtcatg ctgtcattgg tggtcagctc caggttttca tacatggaac caagaatcat
    14401 gtcctggagg gtgacattgt cacccaggga caccagcgcg ccgtccgttg tcttgaacaa
    14461 ttccatattc agcgtttccg aactcccgga aaccagggta tccagattgt tcatgaccag
    14521 cgtgacttcc cccgtcccgt ctcccagcgt aatatttccg ctggaggtga caaagggatt
    14581 gcccaggccg tccaccgttg tggaggaagt ggtaatggcc accgtgctgt cccctgtcac
    14641 gctcaagccg tccgagccaa gcgtcagctg ggttttggga tcgtccgcgc tgccgatatt
    14701 gagcgtgccg ccgttcacgg taatcccctg ataggaagcc tgggcgggat tgccgccctc
    14761 ccctgccgct ccggccaggg tcagcacgcc tccgtcactc acattcaggt gataacctgc
    14821 attgcccgca cccttgatag tctggacgct tccgttgccg gatttgacgt tgagcgttcc
    14881 ggatgccccg tccagcgtac cggtaaaggt atgggaatcg gaagagctga tcgtcatttc
    14941 cgcaccgctc agcttcagag ctccgccgcc ctccagtccg gaaacggtat tcacggaacc
    15001 ggttgcggcg gacagggcgg ccccttcacg gatatccagc aggacaccgt tcagggaaga
    15061 gccgttgccc agtgtcaggg aggagtctgt tcccgtacca cccaaggtca gcgtaccgtc
    15121 cccggagata gtcacttccg tgacatggct gccggcctgc tggccggtaa gaaccatctg
    15181 ggctccgtta cccaaattca gggttccccc tcccacgccg acagccagcg tttccaccgt
    15241 ggttacacgg gaggcgccgt cattccgtcc gcccagcgtt atgtctccgc ccgcgagttc
    15301 cagcgtagta aggctattgc ctgcaccgtt caggatgata tttccctccg aggaactgag
    15361 acaggagtca ttcccggtga agtttccttc tacggtgagg gtttccgcac ctttcttgac
    15421 aaaatccaca tggtccccgc tgatggttcc gccgtagctg ttgccgccgg cgtcaatatc
    15481 ctgaaccaga tccaccacga cgtggttgga ggccgcatca tccgccgtat tcgtcacggt
    15541 cagcgcaccg tcgctgccaa ccagattgct gactttcagg ccgtccccgt tccgggaggc
    15601 ttccggagcc ccgttcaagc tcacatgaag cgtggtgcca ttaatgccga cagccttgta
    15661 gggatccagc gcggcgtaat cgctgatatt ggggttgtct gaattggggg tggtgtccac
    15721 cagatagaca aggtccgtat tgccgctgac catcagcgtc ccgtccgcac ccaggacttc
    15781 cgtcacggta tagccgaggg aagccaggag aggagagaat ccgatttgct tgaaattatc
    15841 cacagccagg gttcccgttg tcagtacaag ccctacgccg tcagtggaat cccggttggc
    15901 ggcaagcagg tccagaacac cctggttgct gaggttgatg gttgttgtgg cggcggaaag
    15961 cgtcaggctg tccgcatcaa taacgccctg tccggtagtt ccgcccgctg taaggctgcc
    16021 ggaatccagt ttcagcgtca ccgtcttgcc cgtcatgtcc agagcaccgg aaacgcctgt
    16081 aagccgggag taatcctcca tgacgatgga gccgaccatg gagccggaca ggccgcccag
    16141 attgatggta ttcagggctc cctgcgttcc ggcggaagcg gccacttcca cgtttccggc
    16201 ggttttggct tccgcgtttg ccaggcttcc cttcgtaatc agaataacgt tggccgcatc
    16261 cagcgaggac agattgagaa caccgttatt gacggtgacc cgtccggacc ccagggagtc
    16321 ggcccccgcc aaggtgacgg tgcccgttcc ggagagcgtc gtggaaccgg tgaacccggt
    16381 gttgccggcc gccagcgtta tctctccggc agtgtcaata accagggaac cggctccgga
    16441 gagggacccg gcccaggcac ttccgtcacc cagccgcgcc gtagcgccgc ccgcaatgga
    16501 gagtgcgccc aggaaggtgt tcgctccggt gagttccagc gttccggcgt ttacggatac
    16561 cgtgctgccg gccgtaccgc tgatgacgcc tccgtaggag aaatcgcggg caaaggccag
    16621 cgtggagttg ttctggatgt caatgctgtc ccccagcttg gccacatcgg cggaattcac
    16681 ggtaaccgtg ccgcggtgca ccttgagctg accgtccagg ttgacgccgc ccgccagggt
    16741 aatattgccc gctccctggg tggagaacgc cgttccgctc aaatcgccgc tgaaggtgaa
    16801 atccttggtg gcaaagacct ggttgcccgt aaagacaacg tcattggcaa aggttcctcc
    16861 ggctgttccg ttccattccg tacggacgtt ggaatccgcc agtttcaaga tgccgtccgc
    16921 ccccatcgtt acgttattca attggaaata gccggatgtc acggacagga tcccctggaa
    16981 ttccgtgctc atattcagga cattggcccc atagctggtt cccagtccca cggaaacggt
    17041 accggaaccg gaggcattca ggttcagagc cgagttatca ttagccccgc tgaccgtcag
    17101 tacggaaccg tccaccaatt ccacggcttt tccattggcc agagccttgg cgacggtggc
    17161 ggccacttcc tcgcccagcg tcacggaacc gcccgtccac gtcatgttgt ctgcggtaaa
    17221 cgccgtggca aaagagccgg aagccaaatt gaggctgccg ccctgcaggt tgatcatgcc
    17281 cattcccggc tgaacgtccg ccgtagccag agtgagcacg ccgtccgtaa cggtaatggc
    17341 tccggatccc agggaattgg cgacctgggc taccagttcg ccctgctgga cggaaatatc
    17401 cccgttccaa cccgtgttgt ccaaattaag gaccagcttc ccttcgccgc gcttggtcag
    17461 cgttccctgg gcgattttcc cggtgccgtt ggaaacgaag acataatcgc ttccggcagc
    17521 attgttgact gtgatggaag caggattcac cgctccggac agagtgacgg ttcccgcccc
    17581 ggtactgttg aagatcagat tcttcccggc agccgtatcc gtggaacctt caatgcccca
    17641 catggcgccc gtgttcgtat cgctccaggt cactccttcc gctccctgcc agatccatac
    17701 gtccccggcg gaagtcacta ccagcttgag ggatgttccc gtctgctcca gttcataaat
    17761 cagcgtttcg tccccggtat atccggccca gttaaagacg gcgctggcgg catcaagacc
    17821 gctggcggcg gaaatcaggg tatattcccc ggcatccgta atgccttcaa gcccgttcag
    17881 cgtaagattg aacgttccgg ccccgaaagc gccgcccact tcgagggcgg agctgatatc
    17941 cagtgtcagc gtagagttgg ccgccaggtt cagggcgccc gcagtcgtca tccgcgtatt
    18001 ggccgccatc gtgatattcc ccagggacgt agccccggaa gcagtaagag cgagcgttcc
    18061 cccctgaata tccgtcagcc ccgtgtagct gaccgttcct cccagcgtca gcgtttcctc
    18121 gccgaccttg gtcagagaca ggacgccgga ttcgtcatac gaaatggaag tggctccgta
    18181 cccaagagca acaccacggt ctgtgagcgt gccgttgtac gtgccggccc ccaccgtcag
    18241 cgtgcgcgca ccgcctacgg ctcccacctg ggaattttcc gttccgtcca gagaggcaat
    18301 ttcaacatcc cccagcacgc gcatgaaagc gaatccggtc gtgtccgttc cggatgtcag
    18361 ggtgacgcca ccctgagaga tggaagtgcg cagatccagc ccggtgctat agccgttgga
    18421 agcattcatg gtgatcattc cggtaaatcc ggaagcgtct ccgctgatga tgagctttcc
    18481 gttggaattg tacctgccgt cgcccgctcc gcggctgtaa gtcagagaac cggctccggt
    18541 gagcgttccg gt
//
