LOCUS       gnlProkkaEPMGIAPC_13   16680 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EPMGIAPC_13.
ACCESSION   gnlProkkaEPMGIAPC_13
VERSION     gnlProkkaEPMGIAPC_13
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 03:48:59
            Original ID  :: gnl|Prokka|EPMGIAPC_13
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16680
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16680
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[6413:6680]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6414..6680
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..16680
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16680
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             262..588
                     /locus_tag="ctg13_1"
                     /transl_table=11
                     /translation="MKNCYGIDFRSWHKELRTREKTKQPPCKLPDRASRSLQGVLFKVY
                     QISVLILLKKILFSFFSVCLPLFIRHIAAMLLRKTSSKTMQTVTKYLKELSGVRSDNSP
                     NSYK"
     CDS             complement(732..905)
                     /locus_tag="ctg13_2"
                     /transl_table=11
                     /translation="MFVYPLFRPSHCPFPGYTTVTHVVCVYTIPPDGRKPYKHRREHPC
                     CYLQGNFQSCEV"
     CDS             954..1169
                     /locus_tag="ctg13_3"
                     /transl_table=11
                     /translation="MKQNTPDGREAYITPSIEVIKMENEGVIATSGEPYHPITRSYSGS
                     TSTHSYNSASSSDLEDLINDILTVEN"
     CDS             1183..4761
                     /locus_tag="ctg13_4"
                     /transl_table=11
                     /translation="MMKLRNLMQVACMATAALTAFSCSQEEFENSGWKGNITVNATFEG
                     AGTDTRTTVNDEYKILWQDTDALGLFCSNAESNYSNTKLEYASGAGQTSATFNGRKPSG
                     ETAVFSIYPYQQNMSVSGNTLTMTLPATLTNYNGSSNGPMYAKVTNPDNLSALSFKHMA
                     AMIKLTVNKIPAEATTFKIIASNNIAGTCTVDLTAADPILTVASNGSKEITASFTASND
                     IKSRNFYIPLPTGTYSSITAQLTNGSDKVYFTKTLNDKILGRRDILVVPPLDCVVVDAT
                     TPSALSTALADSKNLPQEAPTAATVTDIAVSGSFNTTSGSNDGIAIPVLQNSDINLTFN
                     TAPTTSTAAPLTLTDKTNTSVSAPAATATNSVSLAVPETTAEQEAPSVAITMPSTTVTL
                     AAVGNKATYNEVTATTAQQTLIINAGVTVKKLTVKGGNLKIYGKVEQLVHDAGDTTIYI
                     IKGTEASLPATIDSKFVVQSDVAVLKTAFANGEDFKLSADADITGQSVSVPAGKSVVLD
                     LNGYTLTADNSATGKIIVLGKMTLKDSSTEKKGKIVASQDYTAASYNGSLIEIAGEDAS
                     MTMESGNISAVRETPDSNGQYGVGVTDGGDFTMTGGKIEAGWFAVAGNGNYKTQNSIIN
                     ITDGELISTADYAVYLPQSGTTTISGGKVYGAAGGVCIQRGTLNVEGTALITSKGTGST
                     GNWGDGTGGLDCAAINVSGAYGIATVNIKGGTLIAEAKSLITEGTTYTPVINVTGGTFS
                     DPSALKYMKANANVNIKLTADKTCPGFKTTSGQTLTMDLGGKILTLADPTVGSTGTETN
                     SCQLLEGSNVTFKNGTLKSDNNKIMIQNYCNLTLDNMTVEDTNAQYVVSNNCGNISINN
                     TTINAGSNANQFAFDVCGYAKYTAGVTVTVSGTSVINGKVEISKSAGNTELMKLNITSG
                     TFNGDLKVDASVRTENAQSIISVSGGTFSDPSVLKYMATNATVDIKLLSNINIAKTKLA
                     TGYILNAANATANLNLNGHDIINSSETADATPFTQIFTVQNGTLNISGNGNVKCDASAT
                     AKDDGYRMVIEARGYGTVNIHGGSYYNTQKLNTQIDLIYARENGKINIYGGTFESGKYG
                     TPNNDTDGRYWVLNLKNTDKNTASIQVSGGTFINFNPANPNMDDNESYLVTGYEVTRDG
                     SVYTAAHKVGDGRKEYIVGQTSQENR"
     CDS             5008..5934
                     /locus_tag="ctg13_5"
                     /transl_table=11
                     /translation="MRIQILDYQVGPHTFRMVKPSDFNIFKALPSLIPFITTIDTTQKV
                     IFETEIDDDETTTKRTIAKTPDDICFNWEDADCIIRPLPHSSHLVSITPRKSGKNYWME
                     CNDNFRQCFIHLPACRTETPAPENETNFVLNNFLMMLYAFNAARHHTLLMHASVVATET
                     GKGYLFLGKSGTGKSTHTGLWLQQFSDCHLLNDDNPIVHVDSLGKQATVFGSPWSGKTP
                     CYRKESMTVGAFVRLEQAPQNEIEQERAAHAFATLLPSCSCLKQNKEIYNAIVATVTEL
                     ATLAPVYHLKCLPDREATELCRKTVEG"
     CDS             5961..6401
                     /locus_tag="ctg13_6"
                     /transl_table=11
                     /translation="MKKSIPNEILLPEVARLIKEGHTVTITVRGNSMNPFLVDRRDRVT
                     LGDFTTEQLQPGVTVLARDLTERIVFHRIIRRNGDILILQGDGNLAQTEETDIGRVMGV
                     MTEAMRKDKRYTADGKVWKLYSYWWMKLNPARRWLLALFRRI"
     CDS             6414..6680
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_7"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1e-13,
                     bitscore: 41.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.8e-16, bitscore: 48.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIKQGFILHRIGDDYIIMQDGSSNVDFSKVISLNQTSAMLWQEI
                     ENKEFDTDSVTEALTSRYDVDNESARRDAQKFIDSLDREGIIE"
     CDS             6689..7852
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg13_8"
                     /sec_met_domain="NTP_transf_5 (E-value: 2.3e-46, bitscore:
                     148.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQHAFFSLVRSGLWGTPADRQLFRSVSPDDWETVYRMANSQALLA
                     LTFDGISSLPAELRPPRVLYLKWAARTAQIEQANKRLNQLLPELNTLYREAGLHPVLLK
                     GQGIGTNYRTPLHRQCGDIDIYLGKQGQPIANRLLLQQGAIVEGEASDKHASYSLKGVH
                     IENHRIILRLNSPLANRYFQQIIRKWYPQETDYALFSETGKEDSKAVSIAIPPATFNAL
                     YIFLHAFVHFLNSGIGLRQLCDWTCLLANRHKEIDATTLLRQLQDLGLLHAAQAFGYIA
                     VTRLGLPANRLPFPLEGTKQIGEQLLEDILSTGNFGQHDNRIKPRPKGYWAGKWYTFCR
                     ATRRCNELRQFAPYEALWYPVTLIGGTIAIQINRSKGVKDKKARTKK"
     CDS             7875..9545
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 277.6; E-value:
                     3.6e-84)"
                     /gene_kind="transport"
                     /locus_tag="ctg13_9"
                     /transl_table=11
                     /translation="MKKQQKDKKVKKDRREKLRYIREVSAEQRGRILLSCLTGILGVAF
                     ALAFIYATKRVIDTATGITDDNLTHIAVLTVVLLTAQLLCGAADTWISTRMQIETGNAL
                     RHRLFSRLLQSRWNELERFHTGDVVNRVEQDTTAIVTLLTSSVPAFIVTSIQLLAAFLF
                     FYFLDPSLPWLIVAILPVFLSGSRFYMRRMKRYTHDIRNSDGRIQSVIQESLQHRIVIK
                     TLEQGERHLDKLDDLQDMLHSQVMGRTRFSLSAHMLVALAFSGGYLTAFLWGAVHLSAG
                     CITFGTMTAFLQLVGKVQRPVFDLSRLIPSVVNALTAIDRLLELERLPAEADGDSIFLA
                     STPELELKDVTFRYTPDDRPVFSRFSCRFPAGSCIAIVGETGKGKTTLIRLLLALATPQ
                     EGQILLIPAKHPLETNHTVSPQTRKNFVYVPQGNTLFSGTIRDNLLMGNPQASQEAIYQ
                     ALQTATADFVFHLPDGVDSPLSERGGGLSEGQAQRIAIARALLRPGNILLLDEATSALD
                     PDTERLLIKNLRRDCAGKTCIFVTHHPAVAEACESIVRL"
     CDS             complement(9590..10501)
                     /locus_tag="ctg13_10"
                     /transl_table=11
                     /translation="MKPTLFLLAAGMGSRYGGLKQLDGLGPNGETIMDYSIYDAINAGF
                     GKLVFVIRKDFEQDFRDKIISKYEGHIPCELVFQSIDDLPEGFTCPEGRTKPWGTNHAV
                     MMGADVIKEPFAVINCDDFYGRDSFQVMGKFLAALPEGSKNVYSMVGFRIGNTLSESGT
                     VSRGLCGTDANNLLTSVVERTKIQRMDGEVKYIDDNGEWTATPETTPVSMNFWGFTPDY
                     FAYSAEFFKSFLSDPKNMENLKSEFFIPLMVDKLINDGTATCEVLDTTSKWFGVTYPED
                     RQSVVDKIQALVDAGEYPAKLF"
     CDS             complement(10627..12981)
                     /locus_tag="ctg13_11"
                     /transl_table=11
                     /translation="MKRLILYIAGLIFLAGCSTTKHLPEGEILYTGQKPMIVLNRSETS
                     VGEIAMEEVEAALATAPNNSLLGSSTIRYPFPFGLWIYNGFQKYEKGFGKWIFNKFAAT
                     PVLMSTVNPDIRQKAAVNLLRDYGYFNGSVSYKTFIDPKDSLKAKLQYTVNMRNPYFID
                     TVYYRGFSERTTRIMELGRRRSLISSGEQFNVADLDGERTRISTLLRNVGCYYFRPDYL
                     TYQADTMIVPNGHVQMRLIPVPGMPKVAEKQFRVGRKSVYLLGKQGQEPNDSMDYKGLT
                     IHYYNKPPVRPNMLYRWLNYQGYRRKRQIQDSAGIARQRSMQSLYSLYRQTRIQERLAS
                     VGIFRYAEMQYIPRDTAFVSDTLDVRVIAALDKPYDAELDFNVTMKSNNQTGPGAAFTV
                     TKNNVFGGGESWNVKLNGSYEWQTGKASSSLMNSYELGISTSLIFPRVVFPRMGDREYD
                     FPATTTFRLYADQMNRAKYYKLLAFGGNVTYDFQPKSTSRHSITPFRLTFNVLRNPTAA
                     FDTLRAENPALYVSLRDQFIPAMEYTYTYDNASVRGKRNPIWWQTTVASAGNLTSAVYR
                     IFGKPFSEEGKKLFGVPFAQFLKLNSEFRYHYRIDKNQMIASRIAGGVIWSYGNATTAP
                     YTEQFYIGGANSVRAFSARSIGPGGYPPETDRKYTYINHVGDIRIEANIEYRFRMIADL
                     HGAVFLDAGNVWLMRKDENRPNGEFTLKNFPKQIALGTGFGLRYDLDFLVFRLDLGIGL
                     HDPYDTGKSGYYNIPKFKDSMALHFAIGYPF"
ORIGIN
        1 tcatggccgt taggcgtcat aaattcccta tgccacagca gacaaacaaa gggagaagag
       61 taaaggaata cctatgtttt agataaaaat ccacaagctt tcactcgtgc tctccatagg
      121 ttatgagagc aggcttcgcg ctctgtgcga taaattccca tttatcagca ggcatactca
      181 cttacgaaac ttcaattact tatataaatt gtttcagcca aaggcagtac ggacatttgc
      241 aaaaatatgg aaagtcttat tatgaaaaat tgctatggca tcgacttccg ttcgtggcat
      301 aaggagctac gtacacgcga gaaaaccaag cagccaccct gcaaactgcc ggacagagca
      361 agccggagtt tgcagggtgt tctgtttaaa gtatatcaaa tctctgtttt aattttgctt
      421 aaaaagattt tattcagctt cttttcggtc tgtcttcccc tctttattcg ccacatagcc
      481 gctatgctcc tcagaaaaac atcctcaaag acaatgcaga cagttactaa atatttgaag
      541 gagttatcgg gagttagaag tgataactct cctaactcct ataaatgaaa gagacgtgag
      601 cctttcccaa aaaaaataga gaaacataga tacacttaaa caaaaaacaa ttatctttgt
      661 cacaaatccg ctatagcgta gtgggtttat ttacatatta gtaagagcat tattgaaatt
      721 atcttcttta ttcaaacttc gcaactttga aaatttccct gaagataaca acaaggatgc
      781 tcacgtctat gtttatatgg ttttctccca tcagggggga tagtatatac acaaacgacg
      841 tgagtgactg ttgtatatcc agggaaaggg caatgcgaag gcctgaataa aggatataca
      901 aacatagtta ctcacgtttt ttttattgtt taacctttaa ataatttgtg tatatgaaac
      961 agaacacacc agacggtaga gaagcataca tcactccgtc tatcgaagtt atcaaaatgg
     1021 agaatgaagg agtcattgca acaagcggcg aaccttacca tcccattacg cgctcctatt
     1081 cgggcagcac ctctacccat agctacaatt cggcatccag cagcgacttg gaagacctaa
     1141 tcaatgacat cttaaccgta gaaaactaag ggggacttca ttatgatgaa attaagaaac
     1201 cttatgcaag ttgcctgcat ggcaactgct gccttgaccg cattcagttg cagccaagag
     1261 gaatttgaaa acagcgggtg gaaaggaaac atcaccgtta acgcaacgtt tgaaggcgca
     1321 ggtaccgaca cccgtactac cgtaaacgat gaatacaaga ttctatggca agataccgat
     1381 gccctagggt tgttctgtag taatgcagaa agtaattata gcaatacaaa attagaatat
     1441 gcaagcggtg ctggtcaaac ttccgccact ttcaacggca gaaagccaag cggagaaacg
     1501 gctgtattct ccatctatcc ttaccaacaa aacatgagcg taagcggcaa tacattgacc
     1561 atgactctac ctgccacgct tacaaattat aacggcagca gcaatggccc gatgtatgcc
     1621 aaggtgacaa atcccgacaa tctgagcgct ctgtccttca agcacatggc agccatgata
     1681 aaactgaccg tcaacaagat tccggcagag gccactactt tcaagattat tgcctccaat
     1741 aacattgcag gtacttgtac ggtagactta accgcagcag acccgatact gacggtagca
     1801 agcaatggaa gcaaggaaat cactgcctcc ttcactgctt caaacgatat aaaatcgcgc
     1861 aacttctaca ttcctttgcc cacaggtact tatagttcca tcactgccca actgacgaat
     1921 ggaagcgaca aggtatattt taccaagacg cttaatgaca aaatcttagg gagaagagac
     1981 atattggtag tacctccttt ggattgcgtt gttgtagatg ctacaacccc cagtgcgctt
     2041 agtacagctt tagctgattc aaaaaatctc ccacaagaag caccgacagc agcaaccgta
     2101 accgacattg cagtcagcgg cagcttcaat accacttctg gcagcaacga cggcatcgcc
     2161 atcccggttt tacagaactc ggacatcaac ctgacgttca atacagcccc aacgaccagt
     2221 actgccgctc cgttgacgct gaccgacaag accaatacca gcgtaagtgc tcccgccgcc
     2281 actgccacca acagtgtatc cttggctgta ccggaaacca cagcagagca agaagctcct
     2341 tctgtagcca tcaccatgcc aagcaccacc gttacattgg cagcagtagg caataaagcc
     2401 acttacaatg aagtgactgc cactaccgcc cagcagacat tgattatcaa tgcaggcgtc
     2461 accgtaaaga agctgactgt aaaaggcggt aacttgaaga tatatggaaa ggtagaacaa
     2521 ttggtacacg atgccggcga taccacaatc tatataataa aaggaactga agcatcactt
     2581 ccggcaacaa tcgacagcaa atttgtagtt caatccgacg tggcagtcct aaagaccgct
     2641 ttcgccaacg gcgaagattt taaattgtcc gccgatgccg acatcacagg gcaaagcgtc
     2701 agtgtacccg ccggaaagtc cgtggttctt gacttgaacg gatatacact gactgccgac
     2761 aacagcgcaa caggcaaaat catcgtcttg ggcaagatga cactgaagga cagctctacc
     2821 gagaagaaag gcaagatagt tgccagccag gattatacag cggcttctta taatggcagt
     2881 ctgattgaaa tagccggtga agatgcctcc atgaccatgg aaagcggcaa catcagtgca
     2941 gtcagagaga ctccggacag taacggccaa tatggcgtcg gagtgacgga cggtggagac
     3001 ttcaccatga caggcggcaa gatagaagcc ggatggtttg cagtggcagg caacggcaat
     3061 tacaagacgc agaactccat catcaacatc acagacggag aactcatttc tactgctgac
     3121 tatgcagtct atctgcccca atccggcaca acgaccatca gtggcggcaa ggtttatggt
     3181 gccgcaggag gtgtatgcat ccaacgaggc actctgaatg tggaaggtac agccttgatt
     3241 accagtaaag gcacaggtag caccggcaac tggggcgacg gtaccggagg actggactgc
     3301 gccgccatca acgtaagtgg agcatatggc attgccacag taaacatcaa aggcggtaca
     3361 ctgattgccg aagcaaagtc actcatcaca gaaggcacca cttatacacc ggtcatcaac
     3421 gttaccggcg gtacattctc cgacccaagc gcgctgaagt acatgaaggc aaatgcaaat
     3481 gtgaacataa agttgaccgc cgacaagacc tgcccgggat tcaagaccac aagcggacaa
     3541 accttgacga tggacttagg cggcaagatt cttacacttg ctgacccgac cgtaggttcc
     3601 accggcaccg aaacgaacag ctgtcaatta ctcgaaggtt caaacgttac tttcaagaac
     3661 ggaacgctga agagtgacaa caacaaaatc atgattcaga actactgcaa cctgacatta
     3721 gataatatga cagtagaaga cacaaatgcc caatacgtag taagcaacaa ttgtggcaac
     3781 ataagcatca acaataccac tatcaacgca ggaagcaatg cgaatcaatt tgcattcgac
     3841 gtatgcggct atgcaaagta cactgctgga gtcacggtta cggtaagcgg tacgagcgtc
     3901 atcaatggaa aagtggaaat ttccaagagt gcaggaaata ccgaacttat gaagctgaat
     3961 atcacaagcg gtactttcaa cggtgactta aaggtagatg catccgtgag aaccgaaaat
     4021 gcccaaagta tcatctctgt ttccggaggt acattctccg acccaagcgt actgaagtac
     4081 atggcaacca acgcaactgt ggatataaaa cttctctcaa atatcaacat cgccaagacg
     4141 aagcttgcca caggctacat attgaatgct gcaaacgcaa cggcaaactt aaacctgaat
     4201 ggccacgaca tcatcaattc ctcagaaaca gctgatgcca ctcctttcac acaaatcttt
     4261 actgtacaga acggaacact aaacatttca ggcaacggca atgtgaagtg cgatgcatct
     4321 gctacagcga aagacgatgg ttatcgcatg gtaattgaag cccgaggata cgggacagta
     4381 aatattcatg gtggttctta ctataacacc cagaaactga acacccagat agacctgatt
     4441 tatgcaagag agaatgggaa aatcaatatc tatggaggaa catttgaatc cggcaaatat
     4501 ggtacaccca acaacgacac ggatggcaga tactgggtac tgaacttaaa gaatacagac
     4561 aagaacactg ccagcatcca ggtgtccggt ggaacgttca tcaatttcaa cccggcaaat
     4621 ccgaatatgg acgacaatga gtcctatttg gtaacaggct acgaggttac ccgtgacggc
     4681 agtgtatata cagcagccca caaagtcggt gatgggagga aagaatatat tgttggccaa
     4741 acaagtcagg agaaccgata agccaaattc taagaaagga agcaatatat cctcgcaaac
     4801 caaacgaaga gatatcggaa tcgccttatt actatctttt agatgcggcg gacagcggat
     4861 tttcttttat agatctgcgt cctccgcgtc taaagaatga caacaagaca gttgaaaaat
     4921 ctctcaaatc ttcctcattc acacaaacat tcattatttt tctgagtagc ccaaagtatc
     4981 atgaataaca actaacaatc aaaacatatg agaatacaga tattggatta tcaagtagga
     5041 ccgcacacct ttcgcatggt gaaaccttcc gacttcaata tattcaaggc gctgccttca
     5101 ctgattccgt tcatcacgac aatagacacg acgcaaaaag taatctttga aacagagata
     5161 gacgatgacg aaacaacgac aaaacgaacc atagcgaaaa ctcccgatga tatatgtttc
     5221 aactgggaag atgccgattg catcattcgc cctttgcccc acagctcaca ccttgtatcc
     5281 atcaccccac ggaaaagcgg gaaaaactat tggatggagt gcaacgataa cttcaggcaa
     5341 tgcttcatcc acctaccggc ctgcaggaca gaaacaccgg ctccggaaaa cgaaacgaac
     5401 ttcgtactga acaacttctt gatgatgctc tatgccttca atgccgcccg ccaccataca
     5461 ctgctgatgc atgcctcggt tgtcgctact gaaacaggca aaggctacct cttcttaggg
     5521 aaaagcggca cgggcaaaag tacgcacacc gggctctggc tgcaacagtt ctcggactgc
     5581 catctactga acgatgacaa tccgatagta catgtggaca gcctcggcaa gcaagccact
     5641 gttttcggtt ctccgtggag cggaaagaca ccttgctatc ggaaagaatc catgaccgta
     5701 ggcgccttcg tccgcttgga acaagcaccg cagaatgaaa tagagcaaga gagagcagca
     5761 catgctttcg ccaccctcct cccctcctgc tcttgcctaa agcagaacaa ggaaatctat
     5821 aacgccattg tcgccactgt gacggaactt gccacgctgg cacccgtcta tcatctgaaa
     5881 tgcctacccg accgtgaagc gacggaactt tgcagaaaga cggtagaagg ataagttatg
     5941 aatgatgaac tgaacagccg atgaagaaaa gcattcccaa cgagatattg cttcccgaag
     6001 tggcgcgtct catcaaagag ggacatacag taaccatcac cgtgcggggc aacagcatga
     6061 atcctttctt agtggaccgc cgtgaccggg tgacactggg cgatttcacc acagaacagc
     6121 tgcaaccggg cgtcaccgta ctggcacgcg acctgacgga acgcatcgtc tttcaccgca
     6181 tcatccgtcg gaacggagac atactcatcc tgcaaggcga cggcaacctc gcccagaccg
     6241 aagaaaccga catcggacgg gtaatgggcg tcatgaccga agccatgcga aaagacaaac
     6301 ggtacaccgc cgacggcaaa gtctggaagc tctactccta ctggtggatg aagctaaacc
     6361 ccgctcgccg ctggctgctc gccctgttca gaagaatata aaacaaaata accatgaaaa
     6421 tcaaacaagg atttatcctg caccggatag gcgatgacta catcatcatg caagacggct
     6481 cgtcgaacgt ggacttcagc aaagtcatca gcctgaacca aacttccgcc atgctttggc
     6541 aagagataga aaacaaagag ttcgatacag acagcgtgac agaagccctg accagccgct
     6601 atgatgtaga taacgaatcg gcccgtcgcg atgcgcagaa gtttatcgac tcccttgacc
     6661 gcgaaggaat catagaataa ggacggatat gcaacacgct ttcttttcat tggtacgctc
     6721 cggcctgtgg ggcactccgg cagaccgaca actcttccgg tcggtctcgc cggacgactg
     6781 ggaaaccgtg taccgcatgg caaactcaca agccctgctt gcactgactt ttgacggcat
     6841 aagcagtctg ccggccgaac tgcgccctcc acgcgtcctc tatctgaaat gggctgcccg
     6901 gactgcacag atagaacaag ccaacaaacg cctcaaccag cttctgcccg aactcaatac
     6961 cctttaccgg gaagccgggc tgcatcccgt actgctgaaa gggcaaggca tcggcaccaa
     7021 ctaccgcact cccttgcacc ggcaatgcgg agacatcgac atctatttag gaaaacaagg
     7081 gcaacccata gccaaccgcc tcctgctgca acaaggcgcc atagtcgagg gagaagcgtc
     7141 cgacaagcat gctagctaca gtttgaaagg agtacacatc gagaaccacc gcatcatcct
     7201 ccggctgaac agtccgcttg ccaaccggta ctttcagcag attatcagaa aatggtaccc
     7261 gcaggaaaca gactatgccc tattctccga aaccgggaaa gaggactcga aggccgtcag
     7321 tatcgccata cctccggcca ccttcaatgc actttatatc ttcctgcatg cctttgtaca
     7381 tttcctgaac agcggaatcg gcctgcgcca gctatgcgac tggacttgtc tgcttgccaa
     7441 tcgccacaaa gaaatagatg ccaccaccct gcttcgccag ttgcaggacc tcggactatt
     7501 gcatgccgca caagcattcg gctacattgc cgtcacccga ctgggattgc ccgccaaccg
     7561 gcttcctttc cccttggaag gcaccaagca gataggagaa caattattgg aagacatcct
     7621 gtctaccggt aacttcgggc aacatgataa ccgcatcaag ccacgcccca aaggatattg
     7681 ggcaggaaag tggtacacct tctgccgcgc cacccgacgc tgcaacgaac tgcgtcaatt
     7741 tgcaccgtac gaagcactct ggtatcccgt gactctgata gggggaacga tagctataca
     7801 aataaaccga tcaaaaggag taaaagacaa gaaagcaagg acaaagaaat aaaagaaccc
     7861 ggaaaataaa aggaatgaaa aagcaacaga aggacaaaaa agtgaaaaag gacagacgtg
     7921 aaaaacttag gtatattcga gaggtatctg ccgaacaacg cggacgtatc ctgctaagtt
     7981 gcctcaccgg cattctgggc gtggcctttg ccctagcctt tatctatgca accaaacggg
     8041 tgatagacac cgctaccgga ataacagacg acaacctgac gcatatcgcc gttctcaccg
     8101 ttgtcctgct gactgcccaa ttactgtgcg gagctgctga cacttggata agtacccgta
     8161 tgcagataga gacgggcaac gcccttcgcc accgcctctt ctcgcgctta ctgcaaagcc
     8221 gctggaacga attggagcgt ttccataccg gagacgtagt gaaccgggta gaacaagaca
     8281 ccaccgccat cgtcacattg ctcacctctt ctgtcccggc attcatcgtc acgagtatac
     8341 aactgctggc agcctttcta ttcttctact ttttagaccc ttcactgcca tggctgattg
     8401 ttgccatcct gcccgtcttt ctatcaggca gccgtttcta tatgcgacga atgaaacgct
     8461 atacacatga tattcggaac agtgacggtc gcatccagtc cgtcatacaa gagagcctgc
     8521 aacatcgcat agtgattaaa acattggaac aaggcgaacg gcatctggac aaactcgatg
     8581 acttgcaaga catgctccac agccaagtca tgggacgtac ccgtttctcg ctttctgccc
     8641 acatgttagt ggcccttgcc ttttccggcg gatacctcac ggcttttctt tggggagccg
     8701 ttcacctcag cgcaggctgt atcaccttcg gaacgatgac cgcctttttg caattggtag
     8761 gaaaagtcca gcgtcccgtg ttcgacctct cacgcctgat accttccgta gtcaatgccc
     8821 ttaccgccat agaccggcta ttggaattgg aaagactgcc ggcagaagcg gatggtgaca
     8881 gcatattcct cgcctctacc ccggaactgg aactgaaaga cgtgactttt cgctacactc
     8941 ccgatgaccg tccggtattc agccgcttct cctgccgttt ccccgccggt agctgcatag
     9001 ctatagtcgg agaaacagga aaaggaaaga caacgctcat ccggctattg ttggcactgg
     9061 caacgccaca agagggacag atactcttga tacccgccaa acatccactt gaaaccaatc
     9121 ataccgtctc tccgcaaacc cgcaagaact tcgtatatgt cccgcaaggc aatacccttt
     9181 tcagcggaac tatccgtgac aacctgctga tgggaaaccc acaagcttct caagaagcca
     9241 tatatcaagc cctgcaaacc gccaccgccg acttcgtctt ccaccttccc gacggcgtag
     9301 actccccact cagcgaacga ggtggtggac tcagtgaagg acaagcccaa cgcatcgcca
     9361 ttgcccgcgc tctgctacgc cccggaaaca ttcttctttt agatgaagcc acttctgccc
     9421 tcgaccccga cacggaacgg ctgttaataa aaaacctgcg cagagactgc gcaggcaaaa
     9481 catgtatctt cgtcacccac catccggcag tagcggaggc atgcgaatct attgtccgat
     9541 tataatcaga gaataagccc caacgggtat ctgcctttgg ttaacaaact cagaacagct
     9601 tcgcaggata ctcgcccgca tccaccaaag cctgaatctt gtcgactaca ctctgacggt
     9661 cttcgggata agtcacaccg aaccacttgc tggttgtatc aagcacttcg caggtagcag
     9721 tgccatcgtt aatcaactta tctaccatca gcgggatgaa gaattcgctt ttcaggttct
     9781 ccatattctt cgggtcgctc aagaaactct tgaaaaactc tgcactgtaa gcaaaataat
     9841 cgggagtgaa accccagaag ttcatgctga ccggagtcgt ctcgggagtg gcagtccatt
     9901 caccgttatc gtcgatgtac ttcacctcgc catccatacg ctgaatcttg gtgcgttcca
     9961 ctacggaagt cagcaggttg ttcgcatccg ttccacacaa tccacgggat acggtaccgc
    10021 tctcgctcaa cgtattgccg atgcggaagc ctaccatgga atatacgttt ttggagcctt
    10081 cgggaagggc tgcaaggaat ttgcccatta cctggaagga gtcacgaccg tagaaatcgt
    10141 cgcaattgat aacagcaaac ggttccttta ttacatcggc acccatcatt acagcatggt
    10201 tggttcccca aggtttggta cggccttcgg ggcaggtgaa gccttcagga aggtcatcta
    10261 tggactggaa taccagttcg cagggaatat ggccttcgta tttggaaata atcttgtcgc
    10321 ggaagtcctg ttcaaaatct ttacggatta cgaaaacgag cttgccaaaa ccggcattga
    10381 tggcatcgta aatagaataa tccatgatag tttcgccatt cggtcccaat ccgtccaatt
    10441 gtttcaagcc accataacgg ctgcccatac cggctgccaa taagaataaa gttggtttca
    10501 tattagttat tatttaaaaa ggttagtgta tcatagttga taacggttgc aaatgtacaa
    10561 aaatttatgt ctgacaaaag ggagttttag ttcattcttt accactatcc gttcaaaaac
    10621 gtacatttag aacggataac cgatggcaaa atgcagtgcc atactatcct tgaacttagg
    10681 aatattgtaa tatcccgact ttccggtatc atacgggtcg tgaagcccga tacccaaatc
    10741 cagacggaaa acaaggaagt ccaggtcata gcgtaagccg aatcccgtac ccaaagcaat
    10801 ctgtttcggg aaattcttca aggtgaactc accgttcggg cgattttcgt ccttacgcat
    10861 cagccataca ttgccggcat ccagaaacac cgctccatgc aagtcggcaa tcatacggaa
    10921 gcgatactcg atattggctt ctatgcgaat atcacccacg tggttgatat aggtatattt
    10981 cctatccgtc tcgggaggat agccgcccgg acctatactg cgtgcagaaa aggcgcgcac
    11041 actgttggca ccgccgatat agaactgttc cgtataaggt gcagtcgtag cgttgccata
    11101 cgaccatatc acccctccgg caatacgcga ggctatcatc tgattcttgt ctatccggta
    11161 atggtacctg aattccgagt tcagcttcag gaactgtgca aaaggtaccc cgaaaagctt
    11221 ctttccttcc tcactgaacg gcttgccgaa aatacggtag acggcagaag tcaggttacc
    11281 ggccgacgca acggtggtct gccaccagat ggggttacgc ttgccgcgca cggaagcgtt
    11341 gtcataagta taggtgtact ccatggcagg aatgaactgg tcgcgcaaac taacgtagag
    11401 tgccggattc tcggcacgca acgtatcgaa agcggcagta ggattgcgca gtacattgaa
    11461 tgtcaaccgg aaaggagtta tactgtgcct ggaagtcgat ttgggctgga agtcataagt
    11521 gacattaccg ccaaaagcca acagcttata atacttggca cggttcatct ggtcggcata
    11581 taaacggaaa gtcgttgtag ccgggaagtc atactcacgg tcgcccatcc taggaaacac
    11641 cacgcgcgga aagataagcg aagtggagat acccagttca taactgttca tcaaggaaga
    11701 acttgccttg cccgtctgcc attcgtacga accgttcaac ttcacattcc agctttcacc
    11761 gccaccgaag acattgttct tcgtcaccgt aaaagcggca cccggtcccg tctggttatt
    11821 gctcttcatg gtgacattaa aatccaactc cgcatcgtag ggtttatcga gcgcggcaat
    11881 gaccctcaca tccaatgtat cagacacaaa cgccgtatca cgcggtatat actgcatctc
    11941 cgcataacgg aaaataccga cgcttgccag acgctcctga atacgggtct gacggtacaa
    12001 actatacaaa ctctgcatag aacgctggcg ggcaatacct gcgctgtcct gtatctgacg
    12061 tttccgccga taaccttgat agttcaacca acggtaaagc atgttgggac gtaccggagg
    12121 tttgttgtag taatgtatgg tcaagccttt gtaatccatg ctgtcattgg gttcctgccc
    12181 ctgctttcca agaagataga cggatttacg ccccacacgg aactgcttct cggctacctt
    12241 tggcataccg ggaacgggaa tcaagcgcat ctggacatgc ccattgggaa ctatcatggt
    12301 atcggcctga taggtcaggt agtcgggacg gaaataataa cagcccacat tacgcagcag
    12361 ggtactgata cgggtacgct ccccatccaa atcagccaca ttgaattgtt ctcccgaact
    12421 gataagggaa cgtcggcgtc ccagctccat aatgcgagtg gtacgctcgc tgaaaccacg
    12481 ataatatacc gtatctataa agtaggggtt acgcatgttc accgtatatt gcaactttgc
    12541 cttcagcgag tccttcgggt cgataaatgt cttgtagctg acgcttccgt tgaaatagcc
    12601 ataatcgcgc agcaagttaa ccgccgcctt ctggcgtata tcgggattca ccgtagacat
    12661 aagcaccgga gtggcggcaa atttattgaa tatccacttt ccgaatccct tctcatactt
    12721 ctggaaacca ttgtaaatcc acagtccgaa aggaaaggga tagcggatag tagagcttcc
    12781 cagcaacgaa ttgttcggtg ccgtagcaag ggcggcttcc acctcttcca tagcaatctc
    12841 accaacagac gtttcactgc ggttcaatac aatcatcggc ttttggccgg tatagagtat
    12901 ctccccctcg ggcaagtgct tcgtggtgga gcaacctgcc agaaatatca atcctgcaat
    12961 atataatatc agtcgtttca tatcacattc ctactttttc atatcgctat tttcagcctc
    13021 cggttttatc tttttcttcc tgaagatgaa gagttcactc aatcggtcca tcttccggcg
    13081 cagcacaagg ccgacacccg tttcggttat ctcaccgtcg agtatgcttt cgtagttttt
    13141 attatggaat acacggacat atcgagtacc cgacgcatca agacggtatt ccagcgatat
    13201 attgtcaatg aatgattccg catcgttcgt ggcattggcc ccggtggaca cttttccacc
    13261 gatgactatc tgtacgcggt cgttgaagaa acgctgggaa taacgaaaac tgaagtcttt
    13321 ctgcgtgtca cccgtttcag cagaggtacg gtcttccaca cctacactga tattggcgcc
    13381 ttttatacct cccgccaagg agtttatctg gctctgaagc actgagttca aggcagctcc
    13441 cattgacaaa cctcctcctt tggcaccact gttcaagtaa atacccgtgg caagcatggc
    13501 aatggcctgc ttgctacgct cttctgcacc cattgcctgc agctcattct ctactgcggc
    13561 atcttcgggc gccgaaatat cgaatatcaa atcgggagcg tcaagcctgt tcttgatgga
    13621 aatggaaaca tcgaagttca ccatgcgcga accgtccccg tcaccatcgg ccacagaagc
    13681 acgcatacgt tccgtagcct ttaggctcag cgtaggattc ataatattcc cccgccaatc
    13741 cacataactg ccgggattga actggaactc cttcaacggg atgataggca gcgaatattt
    13801 catgacgcca cccgaaaggg tatagcgtcc ggtaaggctc atatcccctt ggggagtata
    13861 ctgcatattc aaatcaccgc caccttccag ttcgatgtat ttgctgcggt cgggactcaa
    13921 gtcagcacga agacggacag catcgtcaat atggacggac atatacattt ccaatcctcc
    13981 caaagacatg gtaggaacct catccgcttt taccgacgtc gtatcggtga acgaggtaaa
    14041 ggtaaccagc ccgctgagac ggtcttccac cgttaaaggg gaatcggtca acacgtaggt
    14101 tacgttggta ttgcccagca aattcatgtt tccacgcatc gtgagcccgt caagcggccc
    14161 cttcaccgtg gcatgcaagt cgacgaacac ctttccatac accagacttt cgcgagtacg
    14221 cggtgcatcc agcaacgtat agttctctgc cagcagattg aggttggcag taggacgctc
    14281 catattccgg aaatcaacct taccgtcaat cgtaaacgga ttcttgctgg tggtataaat
    14341 ggcaaactta tcaaatatca actgattgtc ctttatctgt accggacggt tgtcgaacca
    14401 gtaacgtgct cccgcctggc gtgcatagac agacacactg tccaaaacaa tatcaccatg
    14461 catctgaggc ttgtccagcg aaccataaat ataaagccct ccatcaatat ctccggtaaa
    14521 ggccaccgtt tggtcaggga tgaatgcatt ggccatcttc aatggaaaat gctcgaaacg
    14581 ggtggacact tccagggtat cctttccgtt cttctgcgtc aagataccgt cggcggtcat
    14641 cacttcttca ttatcatatg taaaataggt attcagatag tgcgtattct tgtcgcccgg
    14701 caaccaggta gcccccaggc cgatgtctcc aaccggttgg cgttcgtagg tcagtttctc
    14761 tacattggct tcggcggaca cctgcaggga agtggcagtc tgtatataat ttgcttcggc
    14821 ggagaacaat cccgtaagcc ggggcatata aggaagtacc tccgtaagtt catccaggcg
    14881 caatcggctc agttctacgt ttatattctg caaggaaagg gtatcattct tgtcggattg
    14941 catacggaaa cacagaccat cgtcgctgtc catatcaata ttggcataga cgcgcatatt
    15001 cttatgcaga taaatccagt tactattgtc cgcaaagtgg aatttacgga aagcgataat
    15061 cggctcggca ggaataaggt tcagcagcac accattaccg cgaccgtgtc cttcggtcaa
    15121 cggacgggca ttaataccga atagaacacc ggtctgccct tttccattca cataatccac
    15181 agtcagttcc gcatcttcat tacggacttc acccgtcagt gtgctacgga acacaaactg
    15241 cgggttcttg ggaccgttta tgacaccacc ttgcaacttc atgcgggcag tatcctgctt
    15301 cactgtaaaa aatatcgtat cgagctgcaa ggagtccatg cgcaatccgt gaacagctgt
    15361 acgtccattg atgccgactt gcggagtaaa tccgaagctc agtttgaaat cattatagga
    15421 aatacccttt gcagccagga aatagctgac gggattctgg ttaccggctt ccagatgcat
    15481 gcccgctgaa ggaaggactt ggcgcaaagc ggcatggtcc aaacgccgtt catcaatctg
    15541 ctttgtcagg atagagacaa atttatccga ctgttccatc aacctcttca acgtgctgtg
    15601 agcgcggaaa cgcagattca agtcaccggc atcaagcctc aacttgagag aatcatgacg
    15661 tgcctccgct cccattgtaa aggcaaacgg gtgtttcaac ggtcggggca ccaaacccag
    15721 cttatgcaga ttcacctctt ccacatttaa atccaaagcg ccatccagat agctgcggtc
    15781 aagacgcata tccgcatttc cctgcatctt gagaaggaca ttatcgctgg caagacggac
    15841 ggtagcaacg gatgacttga gtccggcatg cacatctaca ccggaaatgt cccaatggcc
    15901 atactgtagt ttttccaagg aggcattcaa agcggccaca gtttttcgtg atgccacatc
    15961 caccccttgc cccttagcgg acatctttgc cgtaagagta tagatagagt ccttgggcag
    16021 gaagtgatgc acctgcaagt tgttgatggc aaggtcggca tggtaggctt ccgtagcaag
    16081 attataggcg gcgtccaaat tcaaggcgcc ttccttctcc ttcagtttca gggcggcagc
    16141 gcactgcgcc ccctccatac cgagacgtgc cgcaaggtgc atactgtccg gcacaatgat
    16201 ggagccatcg ggagcaatgt cagctagtcc ggtcaggaag ttcaagttct gcgtatgcat
    16261 ttcgaagtcc atgcttccat tgcgtttcac actgtcggtc aagctccaga attctcctcc
    16321 cccactcaac gaaaaggctc cgggcagctc agccgtaaaa cgggaaatct gcatctgctt
    16381 caggtttcct tccgtaccgg catgaatcac caacggacgg aatggatagg cttccttgaa
    16441 agcttccggc aagccaccgg caaaaagcag tacatcctgt ttgccgatac gggcattgaa
    16501 acgggctgtc agacggccgg tggtaggtat atttatcagt tcccagtaag tctgtgccgt
    16561 aaggttcatc tcactatgag gtgtcagcaa cttcaaagaa gggatacgga taacggtaga
    16621 atcggcaaac aaccgtccgg tcagggaggt gacgctcaaa ccggaacgct catacatgga
//
