LOCUS       gnlProkkaAMJMHCEJ_30   10932 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AMJMHCEJ_30.
ACCESSION   gnlProkkaAMJMHCEJ_30
VERSION     gnlProkkaAMJMHCEJ_30
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 04:13:39
            Original ID  :: gnl|Prokka|AMJMHCEJ_30
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10932
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10932
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1618:5932]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1619..5932
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10932
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10932
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3..392
                     /locus_tag="ctg30_1"
                     /transl_table=11
                     /translation="MNPKGSADLVLREGDVVFIPKNTNTVTINGAVMVPNTVSYMKGKD
                     VDYYLNQAGGYSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVPGKAKKKGNIA
                     NILGYATSFSSLGMMIASIANLIKK"
     CDS             407..1555
                     /locus_tag="ctg30_2"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             1619..2338
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 2e-16, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2359..3660
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_4"
                     /sec_met_domain="CTP_transf_like (E-value: 1.1e-12,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.1e-120, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.3e-62, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             3677..4801
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.2e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4811..5932
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg30_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_6"
                     /sec_met_domain="Aminotran_5 (E-value: 8.6e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4901..5908
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg30_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg30_6_Aminotran_5.1"
                     /locus_tag="ctg30_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5929..6072
                     /locus_tag="ctg30_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             6275..7759
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg30_8"
                     /sec_met_domain="Polysacc_synt (E-value: 7.6e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             7713..8972
                     /locus_tag="ctg30_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             8981..9730
                     /locus_tag="ctg30_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             9730..10770
                     /locus_tag="ctg30_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 tgactaatcc taagggtagt gccgaccttg tcctacgtga aggtgatgtg gtctttatac
       61 ctaagaatac taatactgta actatcaatg gtgctgttat ggtccccaat acggtttctt
      121 atatgaaggg aaaggatgtg gattattacc tgaatcaggc cggtggctat tctgataatg
      181 caaggaagag taagaagttc attgtttaca tgaatggtca ggtgacgaag gttaagggta
      241 gtggtaagaa acagattgag ccgggatgtg agattattgt gcctggtaag gctaagaaga
      301 aagggaacat agctaatatt ttaggttatg ctacttcctt cagttctttg ggaatgatga
      361 ttgcttctat tgctaatctt ataaagaaat aatagaattt acttttatgt cagaacaacg
      421 acaggataaa aacttgctct ctgaaccaca caagacagaa agtgatgaga tagaaattga
      481 tttggtcgat atctttcgca agattattgc tattcgtaaa aaattataca aagccgttgg
      541 aattggtttt attattggaa taattgtagc ggtaagtatc cctaaacagt atacagtaaa
      601 ggttaccctt tctcctgaaa tgggtaatgc gaaggggagt aatggtttag ccggacttgc
      661 tgcctcgttt ttaggagatg gggctctaat aggggaaagc acagatgcct tgaacgcttc
      721 tctttcagca gatattgttt cttcaactcc ttttttattg gaacttttag aaatggaagt
      781 ctccgtttct aaaaaggatg ataaaatgac tttggggtct tatctcgatg aagagtcatc
      841 tccttggtgg gattatctta taggttttcc gggcatagta ataggaggag ttaaatcatt
      901 attcggagaa gatacggttc ctgccagtgg agggcggcaa ggaactatcg aattgacgaa
      961 agaagtaaat gagaagatta attttcttaa aaagaagatt agtgcatcca ttgataagaa
     1021 aaccgccata acgagcatta cggtcacctt acaaaatccg cagatcactg cggttatagc
     1081 agattctgtc gttcataaat tacaggaata tattattggg tatcgaactt caaaagtaaa
     1141 agaagactgt gcgtatttgg aacggttgtt taaagaacgt cagcaggaat attatgctgc
     1201 tcaaagaaaa tatgcggatt atgtagacgc ccatgataat gtggttcttc aaagtgtacg
     1261 tgctgagcag gagcgtttac agaacgacat gagtttggct tatcagatat atagtcaggt
     1321 tgctaatcag ttgcaggtat ccagagccaa agtacaggag gaaaagccag tctttgcagt
     1381 agttgagcct gccgttgtac ctttgaaacc ttcaggtatg ggactcaaaa tttatatttt
     1441 attatttgtg ttcctgtccg tatctggtac tctcgtgtgg gtgttttttg gcaaaagtct
     1501 gctggctagc ttgagaaaag aactgaaaaa taaggagata gaacaggata aatgatgcta
     1561 aaacgtcgtt tacaacattc ttacatcaat taaattcact tactatatta ttaaacgaat
     1621 gatacgtaca gctatgataa tggctgcggg catgggaacc cgttttggcc aatatacaga
     1681 attgatacct aaagggttcg tcaaagtggg aggtattcca atgatagttc gttctattga
     1741 tactttgtta tcatgtggca ttgagcgaat tgtaatcggt acaggatata aacaagaagt
     1801 ttatgaagaa ttgaagacag actatcctat gcttgaaacc tgttttagtc ctcgttatgc
     1861 tgaaacaaat agtatgtata ctttatataa tacgcgggag attctgggca atgatgattt
     1921 tttattgtta gagtcagatt tgatttttga gaaacaagca ataatgagct tattggagtg
     1981 tcctgcggca gatgcaatgc taatagctcc agtgacaaag tttcaagatc agtattatgt
     2041 ggaacatgat gataattttc gcctttcttc atgttctgtc aataagaata aactaaacgc
     2101 taaaggcgaa ttggtcggca tccataaact atccggttcc ttttacaaaa taatgtgtgc
     2161 tgattatgcg agtattgttg atgaacaacc caatttggga tatgagtatg aattactacg
     2221 aatatcttgt tctcaatctc ctgtttatgt gcataaagta gaagggctga aatggtatga
     2281 aatcgatgac atatcagatt tggaatatgc agagaaatat attgttccgt attgttaatt
     2341 aaaataatat atcaaattat gagtaagaca gtttatattg ggatgactgc ggatattatg
     2401 catccaggac ttatccgcat tattaatgag gctactaaat acggtgatgt tataattggt
     2461 cttcttacag ataaagctat tgcggagcat aaacgccttc cttatctgac ctatgaacaa
     2521 cgaaaagagg tagttcagaa tattaaaggc gtatgtaaag ttgttcctca agaagaatgg
     2581 agctatgttg agaatctcaa acgcattaaa cctgactata taattcatgg tgacgactgg
     2641 aaaaccgggc ctttacgtga agaacgtgtg cgcgtatttg aagtgatgaa tgaacaggga
     2701 ggaaaggtta tcgaaattcc atatactttg ggaattaatt catcttcttt ggataaagat
     2761 attaaggcta taggtacaac ccctgatgta cgtttaaaat cacttcgtcg tttgataaat
     2821 gccaaacccg tagttcgtat tttggaagct catgatggac tatgtggctt gataattgaa
     2881 aatcaggaaa tattaaaagg ggataagagg gaagtatttg acggaatgtg gtctagtagc
     2941 cttacggatt caaccagtaa aggtaaacct gatattgagg cggttgattt aactacccga
     3001 ttgcaagatt tgaataatat tctggagtgt actactaaac ctattatttt tgatggagat
     3061 acaggtggta aaattgaaca tttcgtattt acagtacgca ctttagaacg tcatggaatt
     3121 tcagctataa taattgaaga taaagttgga ttaaaaaaga attcattgtt tggtacagat
     3181 gttattcaaa ctcaagatac aatcgaaggt ttctgtaata agatcaaagc aggaaaggca
     3241 tctcagatta ctgatgattt tatgattatc gctcgtattg agagccttat agcgggaaag
     3301 ccggtaagtg atgctttaga gagagctttt gcatatgtcc aagcgggagc ggacggtatt
     3361 atgatacata gcaaaaataa gtcgggtgaa gatataaaag aattttgttt ggcgtttcga
     3421 aaacagtatg ctcatgtacc tatcgtggtt gtgcctacta catatgatca tatttatgag
     3481 tctgaattgt gtgattgggg tgtgaatata attatttatg ctaatcatat gcttcgtgcc
     3541 gcttatcctg ctatgatgaa tgtcgcaaag ataatattag agaatgaacg tgctttagag
     3601 gtgcgcgaac tgtgtatgcc cataaaagaa atattggaac tgattccagg tactaaataa
     3661 aaagaggaat atcattatgt taagcgtaga aaaagtttat gaaacgtttc tgagtcatga
     3721 cgttgatttt tttacaggag ttccagactc attactaaaa aatatttgtg cctatatcac
     3781 agaccatact tcacgtgaga aacatatcat agctgctaat gaaggtgcgg ctgtaggaat
     3841 tgcttcaggt tattatatgg catcaggtaa ggttcctgtg gtttatatgc aaaattccgg
     3901 cttgggtaat actgttaatc ctctgctgtc tcttgcagat gaacaagtat acagttttcc
     3961 aatgcttttg atgattggct ggcgtggtga accgggaaca aaagatgaac ctcagcataa
     4021 aaaacagggt gaggtaactt tagatttgtt gaaagcaatg cggattcctt atataattct
     4081 tgattcaaat gagaatgatg catttattca gctccatgat atcatacaat cagcaaaaac
     4141 taagaatatt cctcatgcaa taattattcg gaaagatgtt tttggcaaat ataaacttca
     4201 aaaagagttc ggatgtaatt atcctttatc tcgtgaggat gctttgcaaa tagttgtgga
     4261 ttatctgcct gaaaattcag tggtcgtttc tactactggc aagctttctc gtgagttatt
     4321 tgaatatcga gaaatgaaag agcaaggtca tgaacatgat tttctcacgg taggctctat
     4381 gggacatagt tcatcaatct ctttgggtat tgctatagca aagcaagata gacctgttta
     4441 ttgcttggat ggtgatggag catttattat gcatttaggg gcaattagta acattggcga
     4501 tttatctcct aaaaactatt atcatatttt gtttaacaat ggtgctcacg agtctgtagg
     4561 aggacagcct actttaggat ttagtttaga tattccggct attgtccggg ggagcggata
     4621 taagcatact tatactgttt gtacaaaagt tgaaattgaa gaagcaatga agcagcttcc
     4681 aaagttatgt ggtcctgttt tgttggaaat aaaggttaaa atagattctc gggagaattt
     4741 gggacgtccc acgactactc ctatagagaa taaggagcat tttatggatt ttttaaaata
     4801 aatatattcg atgaaaatag aaagaaaaat attattaaat cctgggcctg ccactactac
     4861 tgacagtgta aaaatggcac aagttgttcc ggatatttgt cctcgcgaga aagaattcgc
     4921 aggtatgatg aaacaacttc gggacgattt ggtcagagtt gctcatggga atttggaaaa
     4981 acataccgct gtattatttt gtggctcagg aaccatcaat attgatatat gtctaaattc
     5041 tcttcttcct gaagacaaaa gggtgcttat agtgaataat ggggcatata gtacccgtgc
     5101 tgtagaagtg tgtcaatatt atggtttgcc tcatattaat ttggaatttt ccgtttacga
     5161 acgtcctgat ttatcggtgg tggaaaatgt gttgcaagaa aatcctgata tagctatggt
     5221 ttatactact catcacgaga cgggtacagg aattctgaac cctattcgcg agatgggcgc
     5281 tatagctcat aaatatcagg ctaaatttgt cgtcgatact acttcttctt tgggcatgat
     5341 tccttttgat atagagaaag ataatgtgga tttttgtatg gcatctgctc aaaaaggact
     5401 tcaagcgatg acaggtcttt cttttattat aggcaatgag gaacagatta agttttcaaa
     5461 aaaatatccc aagcgttctt actattgtaa tctttatttg cagtatgaga attttgagag
     5521 aacaggtgaa atgcatttta ctccaccggt acaaactatt tacgccactc gtcaggcatt
     5581 aaatgaatat tttgaagtgg gtgaagaagc taagtttgcc cgtcacaaaa gagtttttga
     5641 ggctattcat tcaggtataa atgaaattgg tcttaaaagt gtaataaagc gtgaatggca
     5701 gtcaggactg gttgtctcag ttcaataccc agaagatccc aactgggatt ttgagaaaat
     5761 acatgattat tgttatgagc gtggatttac gatttatcca ggtaagatat caactgagga
     5821 tacttttaga atctgtgctt taggagagat agaagtagat gatattgaga acttctttaa
     5881 agtactaaaa gctgcattaa atcattataa cgtcacatta ccgatgtcat gattgcagaa
     5941 atattattga agattcgtca tttttatttt tcccttcgtg gtatacactt ccatccggaa
     6001 agtgttattt ctggagtgcc tattcgtagc tttcgcttag taggcaaata tggcaatatt
     6061 aatttgaggt gatgcattag gagttcttta ttcttataaa aaggcatcgg tagttatagg
     6121 agataatgtt tgtgtagggt aatttgcttt tagtgggaga gaccatatta gaattgcggt
     6181 aaggggcgaa gaagataata accaattagt gagaatattg gaaaaatata attgatatcg
     6241 gtaaatgtag ttgtttttat actgtattta agtaatggaa aatctaaagc agaaaactgt
     6301 atcaggaata atgtggagcg ctatagaacg tttctcttta caaggagtac agtttataat
     6361 tcaaataata ttagctcgtt tgttactacc atcggattat ggtatgatcg ggatgttagc
     6421 tatttttctt caagtcgctc aagtatttat agatagcggt tttacaaatg ctttaatcca
     6481 gaaaaaagat agaactgaag aggattttgc cactgtcttt tattttaata ttcttgtcgc
     6541 agtattattc tatggtatat tgtttttttc ggcttctttg attgcagact tttataatat
     6601 gccgacttta gttcttgtaa ttcgttttat agcattgtcg ttgataataa atgctttatc
     6661 ggctattcac agaacgaaat taattatttc tgtaaacttt aaaactcaat ctaaaatttc
     6721 attaggtgca gcttttatat caggcgtgat tggaatatgg atggcttatg tcggttgcgg
     6781 ggtttgggct ttagtttggc aaactctctt aaatagtata attttgacaa ttttgtttta
     6841 ctgtttagtt cattggaaac ctttacatac tttctccaaa agttcttttg aaagattatt
     6901 caatttcgga tctaaattat tgatctcaag tcttatcaat acagtatatc gtaatctgta
     6961 taccattgta ataggaaaaa agttttctgt tgtagagctt ggttactata caagagcaga
     7021 acaatttgct atttttcctt ccaataattt aaatgcttta gtttctagag tagcgtatcc
     7081 tattttaagt tccattcaag atgatgataa atgtttaaca aacgcatatc gaaattatat
     7141 cagattatcc tcatatataa tttttccttt aatggtaggt ttacttgttt tggctaatcc
     7201 tattattagt ctattgttaa cagataaatg gtctggggtt gttattcttt tacagatatt
     7261 atgtttggat tggatgtttg atcatttgag ccaaattaat ttgaatttat tatgggttaa
     7321 aggaagatct gatctgtcgt tacgtcttga aataataaaa aagacgattg ctatattcat
     7381 tctttttgtg tcaattccat ttgggcttga ggtgatgtgt tggggtagag ttatttactc
     7441 tctgatagcg acatatttga atacatatta tactaattct cttattgatt tgaccttaaa
     7501 gttgcaagtt aaagatgtat ttccaagttt aatactctct ttcataatgg gggggatcgt
     7561 ttttatatgt atttctttct ttgaaactga tatagtaaaa attgtgattg gatgtattac
     7621 tgggatgtcc ttctatattt tactttcttt tctttttaag ctagattctt ttttttgtat
     7681 tttaacattg atcattaaaa ctaaaaacat agatgaaaat attaaaaaag atttttcaag
     7741 taatagtaaa gataattaac cattgtgtgc cagttgatag tagatcattg tattttattc
     7801 ctcatcctaa ttgtagaaca gataaatatg atattataaa ttattcgtca gataatgttc
     7861 tcgttctgtt aaattatttg ctaaaaaaag atagtgctga atattataaa atatatgttg
     7921 aaatttatga ttcttctcgt atttcagaat atcaagaata tatttatggc ataaatccta
     7981 atattaggtg tactttttta tgtgcatgtg ttggacgttt tttctttaat aaagtatctt
     8041 ttaaggatat gttgtatgcc tttttttgtt tttgtagagc aagtaaatgt tttacagcta
     8101 ctttttatta tgatttttca tttaaaaaac gctctcaaca gattatttgt ttggggtatt
     8161 atactccatt caaagatgat tatcatatgg gagatcattc ttatgataaa tttcgtaata
     8221 caacatgtaa ctcatttgat tactctattg ctacttcttg tttaagtgct agaataattt
     8281 caatagattg tggaatctca tatgataaat tcaaagtctt aggatttccc agaaatgatt
     8341 tgttgatatc gaaaaataat tgcaatgtta ttaaaagaga aatttcgaaa tttgcgggat
     8401 atgatgtaac taaatatata gtttatactc caacttttcg tgattatgag actgttactg
     8461 aaggtaattt gcgttcaata ctcggatatg ttgattgtga tttgttgaag ttatcgaaaa
     8521 tactattgaa gtttaatgcg gctttaattc ttaaattaca tcctttgcag aataaaacag
     8581 tcttaaaaaa agatttaccc aaaggtatac ttgtttttga acaaacatat aaatatggat
     8641 tgtatgatct tttgtcattt tcagatggaa tgattactga ttatacttct acctattttg
     8701 attttttatt ggtaaataag ccagtcatat ttaatttcta cgatattgaa gaatatcgta
     8761 gagtaagagg tttctcattt gagccaatag aatttttttg tgcaggtgat attgtttaca
     8821 attataatga attgatagat gctgtgatgg gacttctggc tgggaaagat attcatgctg
     8881 aacatcgacg tcatatttct ttattgatga atcaatttca agatgataat tcaacaaaga
     8941 gaatatgtga catattttta aatgaaatat aataaataaa atgaattatg catttgtggt
     9001 gcaggcacgt ttaggttcta cacgtttgcc tggaaaaata ttgaaacctt tctatggtaa
     9061 tcaatcgatt cttgacttaa tggttcataa gctttctgct atatcgaata ttccagtaat
     9121 tattgctaca acaaattctg ttatcaatga acctattgaa aagaaggcac ttgcattagg
     9181 ggtaaagtgc ttcagaggtg aggagaatga tgttttaaaa cgattcattg atgttgctga
     9241 atattttgat atacagggta tattccgaat atgttctgat aatccatttt tagatgtaca
     9301 tgcggcaagg caattggtcg aaatagcaat gaaatcttgt aacgattata taagttttga
     9361 tattgatggt actccatcaa ttaaaactca tttcggtttt tggggagaat ttgtaacgct
     9421 tgatgcgctg aagcgagtta taggatttac tgatgattta ttgtatcgtg aacatgttac
     9481 taattatata tatagtcatc ctgaactttt taatattcaa tggatttcag gatctccagt
     9541 cgtgtcaaaa catcataata ttcgactcac gattgatacg ttagaagatt tttctgtagc
     9601 acagagaata tatagggatt tacaagaaaa aagagtggaa atatcgatag aagtgattgt
     9661 agactatgtt cgaagacatg cagaatacat tcaactgatg aaacaacaaa taaaaaaaaa
     9721 ttctaaataa tgaagaatac ttatattatt ggtgaaatag ggcagaatca taatggttct
     9781 gttgacttgg ctaagttgat tattgaatta atctcacgac ctgtacatga ggatgttttt
     9841 ggtatggatt tcatgccaat gaatgctgtt aaaatgacta aaagagattt atcagaagaa
     9901 ttggctgttt ctcaaatgaa tcaaatatat gacaatccta attcttttgg gcgtacttat
     9961 ggtgaacatc gtgcttttct tgagcttgat gatcaagcgc attttgagat ttataaatat
    10021 gctaagtcat taggattaga ttttatcgag acgttatgtg ccaaaggatg tctgtctttg
    10081 cttaaactgt tcacaccgga taggctaaaa gttgctagtc gtgatttgac taacttacca
    10141 ttgcttgaag cattagcaga aactcatatt cctattatat tatcgacagg aatggctggt
    10201 caaagagaac ttgacaatgc attagatgtg ataacgagat atcatagtaa tatagctatt
    10261 ctacattgtg tatctcagta tccaactcat ccaaataatt tgaatctacg tacaataaca
    10321 tatttgaaga agcattacaa taagtttgag ataggttttt ctgatcatac aataggtatt
    10381 tctgctgcta cagctgctgt agcgatggga gcggaaatta tagaaaagca tgtaacaatt
    10441 gatcggcata tgaaaggaac agaccagctt ggctctttag gtccagatgg ggttaatcgt
    10501 atgattcgag atattcgcat agcagagtgt tggcttggta ctgaagatct ttatatagaa
    10561 aaaggggtgg agaagtctaa gataaaactt gaacgttcta ttgccactcg aaaatatatt
    10621 ccagcaggta gtattattca agagtcggac attcatttac tgagtcctgg tgatggttat
    10681 aaatggatag ataaaaaaaa tgtaattggt cattttgcta aacaagatat atcagcgaat
    10741 gaaataatat atcctgattt tattgaatag atatattcct actgcaactt gtattacggt
    10801 atagagtact gcctgctata agctaagtag tgattaataa ataagggtaa aatactaaaa
    10861 aaatgaaaga gataaagctt atacttacag atattgatgg cgtttggact gatggcggaa
    10921 tgttttatga tc
//
