LOCUS       c00080_gnlPro..        13780 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GHLGEGDM_80.
ACCESSION   c00080_gnlPro..
VERSION     c00080_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 18:03:13
            Original ID  :: gnl|Prokka|GHLGEGDM_80
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13780
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13780
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4306:10286]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4307..10286
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13780
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13780
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2..526)
                     /locus_tag="ctg80_1"
                     /transl_table=11
                     /translation="MKIHSYIFSLLACLVIALPGYSQVDRNETLIRSALHGLEYEIKAG
                     FSIGGTAPLPLPVEIRSIDGYNPTLAISIGGEVTKWFAVQNKLGVIVGLRLENKAMTTE
                     ATVKNYNMEILGQGGERISGVWTGGVKTKVHTSGLTIPLMATYKLSSRWNIKAGPYISY
                     LLSREFSAHVYE"
     CDS             complement(617..1702)
                     /locus_tag="ctg80_2"
                     /transl_table=11
                     /translation="MKAKHGILYLLLAIFSSSCIREEAPNAEADILSCRLPGVVMTTSP
                     IITNNSINIFVGPGTDISSLAPEFTLTPGATIDPPSGTARDFHSPQQYTVTAADGFWKK
                     KYTVSVIDTELATIYNFEDTLGGQKYYIFVEREGEKVVMEWASGNAGYAMTGVPKTADD
                     YPTFQFANGKTGKCLSLVTRSTGFFGSIMGMPIAAGNLFIGSFDVGNAMSNPLKATKFG
                     LPFRHIPTYLAGYYKYKAGDQFTEGGKPVSGKRDICDIYAIMYETSESVPTLDGTNAFT
                     SPNLVSIARIDDAKETDEWTYFKLPFHMLSGKYIDKEKLTAGKYNVAIVFTSSLEGDHF
                     NGAIGSTLLIDEVELIYRSED"
     CDS             1836..3125
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg80_3"
                     /sec_met_domain="SDH_alpha (E-value: 9.2e-63, bitscore:
                     201.8, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIESERKQIIDLIKKEVIPAIGCTEPIAVALCVAKAAETLGMKPE
                     KIEVLLSANILKNAMGVGIPGTDMVGLPIAVALGALIGRSEYQLEVLRDCTPEAVEQGK
                     LFIAEKRICISLKEDITEKLYIEVICTAGSQKATAVIAGGHTTFVYIATDEKVLLDKQQ
                     TANEEEEDASLELNLRKVYDFALTSPLDEIRFILDTARLNKAAAEQAFKGNYGHSLGKM
                     LRGTYEHKVMGDSVFSHILSYTSAACDARMAGAMIPVMSNSGSGNQGISATLPVVVFAE
                     ENGKTEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGNYNQVA
                     FAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAMMAMEDRCVTSVEGIIDEDVDQ
                     SIRNLTRIGSQAMNETDKMVLDIMTHKGGC"
     CDS             complement(3257..3832)
                     /locus_tag="ctg80_4"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYTVEDGEKELFEETNAEHPFQFISGLGTTL
                     ESFENQITALSKGDKFDFTIPADEAYGAYDEQHVFDLPKNIFEIDGKFDSERVTEGSIV
                     PLMTGDGQRVNASVVEIKPDVVVVDLNHPLAGADLIFEGEVIESRPATNEEIQELVKMM
                     SGEGCGCGCDSCGSDCGDDCGCEGGHCH"
     CDS             4307..6109
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_5"
                     /sec_met_domain="ILVD_EDD (E-value: 2.6e-218, bitscore:
                     715.2, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADDSVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRTRLFEDAAKLIVENAMKYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGVDFKMDDIDMLSRKTPCLCKVAPNTQKYHIQDVNRAGGIIAILAELAKGG
                     LIDTSVLRVDGMSLAEAIDQYSITSPNVTEKAMSKYSSAAGNRFNLVLGSQGAYYQELD
                     KDRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEA
                     ACEGILGGRVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIVDGDIIEIDIPARTINVRLTDEELAARPMTPVTRDRY
                     VPKSLKAYASMVSSADKGAVRLID"
     CDS             6157..7854
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_6"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.6e-47, bitscore:
                     149.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNT
                     LNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLD
                     FAKNAQVEKTKYEPTQQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGS
                     AQEELRIFIEKADMPAGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVG
                     MRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNR
                     HTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQM
                     ISARYFKYTRERSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVF
                     SREELKAAIDEMLSTDGAFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             7873..8436
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_7"
                     /sec_met_domain="ALS_ss_C (E-value: 6e-20, bitscore: 60.9,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKKEQE"
     CDS             8436..9179
                     /locus_tag="ctg80_8"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKDGK
                     KIGYARSVWAMINLNTRKPADLLALHGGSIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGNELSFFCDEV
                     SENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             9243..10286
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_9"
                     /sec_met_domain="IlvN (E-value: 3.6e-47, bitscore: 149.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.9e-40, bitscore: 128.0,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(10819..12765)
                     /locus_tag="ctg80_10"
                     /transl_table=11
                     /translation="MKYIFVSGRRFITFASIMNNHPKSPIIDLQQQQLLLRMEYEHEKE
                     EFKRQTETMGVARKVKRGLCWYPASPGRSYYNSLNQLVIDITRTENKEIEHSFEFGRPV
                     CFFRQSFDGKVNYMNFIATVSYADDERMVVVLPSAGALLELQTEEVLGVQLYFDETSYR
                     AMFEALEDTIRAKGNRLAELRDTLLGTQKPGFRELYPVRFPWLNSTQETAVNKVLCTRD
                     VAIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSNTAVDWICEKLVDRGVPVLRIGN
                     PTRVNDKMLSFTYERRFENHSAYPELWGIRKSIREMGSRMRRGSYSEREGMRSRMSRLR
                     DRATELEILINADLFDSARVIASTLVSSNHRLLNGRRFPTLFIDEAAQALEAACWIAIR
                     KADRVILAGDHCQLPPTIKCIEAARGGLDHTLMEKVVQQKPSAVSLLKVQYRMHEAIMR
                     FPSEWFYNGELEAAPEVRNRGILDFDTPMNWIDTSEMDFHEEFVGESFGRINKQEANLL
                     LQELEAYISRIGKARILDESIDFGLISPYKAQVQYLRSKIRGSSFLRPFRSLITVNTVD
                     GFQGQERDVVFISLVRANEDGQIGFLNDLRRMNVAITRARMKLVILGDATTLTKHAFYR
                     KLIQYIRQEAVSS"
     CDS             12832..13779
                     /locus_tag="ctg80_11"
                     /transl_table=11
                     /translation="MVYDLTMLEAFYSAYKGKVEHVRAVLKRPLTLAEKILYAHLFNEG
                     DLKNYKRGEDYVNFRPDRVAMQDATAQMALLQFMNAGKEKVAVPSTVHCDHLIQAYKGA
                     KEDIATATKTNEEVYDFLRDVSSRYGIGFWKPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRIIGVRLTGKLSGWTSPKDVILKLAGI
                     LTVKGGTNSIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPFDGRMATYLRATGRD
                     RIVELAEAVDCELRADQQVTDEPEKYYDRVIDIDL"
ORIGIN
        1 cttcatatac gtgcgccgaa aattctcttg aaagcagata cgaaatataa ggtccggctt
       61 taatattcca acggctgctc aacttgtaag tagccattag aggaattgtc agtccggaag
      121 tgtggacttt ggttttgact cctcctgtcc agacaccgct gattctttct cctccctgtc
      181 cgaggatttc catattatag tttttgacgg tggcttccgt tgtcatggct ttattctcca
      241 gccgcagccc tacaatgact ccgagcttgt tttgaacggc aaaccatttg gttacttctc
      301 ctccgatgct gatagccagc gttgggttgt agccgtcaat cgaacggatt tcgacaggca
      361 gcgggagcgg ggctgtaccg ccgatgctga accctgcttt gatttcatat tccagtccgt
      421 gaagagcgga gcgaataagt gtttcgtttc tgtcaacctg tgaatagccg gggagggcta
      481 tcaccagaca ggcgagtaaa ctgaatatat aggaatggat tttcatcttt tcattattat
      541 taaatcatta gttatttcat tatagttgct ctgttctgcc ttccatagct gctatcagat
      601 cgttggtcga atggaatcag tcttccgagc gatagattag ttcgacttca tcaatcaaca
      661 atgtacttcc gatagctccg ttaaaatgat ctccttccag gctggaagtg aatacgatag
      721 ctacattata ctttcctgct gttagcttct ctttatctat gtattttccg gataacatat
      781 ggaagggaag tttaaagtat gtccactcgt ccgtctcttt ggcgtcgtca atgcgtgcta
      841 ttgaaaccag gttgggactg gtgaaagcat tcgttccgtc aagagtcggc acagattcac
      901 tggtttcata catgatggca taaatatcgc atatatcccg tttgccactg acgggtttgc
      961 cgccttctgt aaactgatct ccggctttat acttgtaata gcctgccaga taagttggta
     1021 tatgccggaa aggcagaccg aatttggtcg ctttcagtgg attgctcatt gcatttccta
     1081 catcaaaaga gccgataaac aggttcccgg ctgcgatagg cattcccata atgctaccga
     1141 agaatccggt actgcgggtt actaaggaca ggcattttcc ggtttttccg tttgcaaact
     1201 gaaaagtcgg atagtcgtcg gctgtcttgg gaactccggt cattgcataa cctgcgtttc
     1261 cgctggccca ttccatcacc actttttctc cttcccgttc tacgaagatg tagtatttct
     1321 gtccgccgag cgtatcctca aaattgtaaa tagtagcaag ttccgtatca ataacggata
     1381 cggtgtactt cttcttccaa aagccatcgg cagccgtaac ggtatattgc tgaggcgaat
     1441 ggaaatctct agccgtccca ctgggaggat cgatagtggc tcccggagtc aatgtaaatt
     1501 cgggtgcaag ggatgaaatg tccgttcccg gtcctacaaa tatattgatg gaattattag
     1561 tgataatcgg actcgttgtc atgactactc ccggcaatct gcaactgagt atgtctgcct
     1621 ctgcattggg agcttcttcg cgaatgcaag aagaagagaa aatggctagc agcaaataaa
     1681 gaataccgtg ttttgctttc atttttctac tattctaact gttaaagttc ggttcttgga
     1741 agattttata acaatctgca attttatttg ttcactaatg gatgtttgat aaaaaagaat
     1801 tttctacttt tgtggaaact aaagccttat agggtatgat tgaatcggaa agaaaacaga
     1861 taatagactt gatcaaaaaa gaggtgattc cggcgatagg gtgtacggaa cccattgcgg
     1921 tagcgctttg tgtagctaaa gctgctgaaa cattaggaat gaaaccggaa aagattgaag
     1981 tgttattgag tgccaatata ttaaagaatg caatgggagt cggtatcccc ggcacagata
     2041 tggtcggact tcctatagct gtagccttgg gagcgttgat cggccgatcg gaatatcaat
     2101 tggaagtgtt gagagactgc acaccggagg cagtagaaca aggcaaactg tttatcgcag
     2161 agaagcgaat ctgtatttct ctcaaagaag atattacgga aaaactgtac atcgaagtaa
     2221 tctgcacagc cggcagccaa aaagcgacgg ctgtgattgc cggcggacat actacctttg
     2281 tctatatagc tacggatgaa aaagtactgc ttgacaagca acagactgcc aatgaagagg
     2341 aagaagacgc ttcactggaa ctgaatctgc gcaaagtcta tgattttgcc ctgacatccc
     2401 ctctggatga aatccgtttt attctcgata cggcacgtct gaacaaagca gccgccgagc
     2461 aagcctttaa aggcaattat gggcattctt taggtaagat gctccgtgga acgtatgaac
     2521 ataaagtgat gggtgacagc gtattctctc atatactatc ttatacttcc gccgcttgcg
     2581 acgccagaat ggctggtgca atgattcccg tcatgagtaa ctccggcagt ggcaatcagg
     2641 gcatatccgc cacacttccc gttgtcgtat ttgccgaaga aaatggtaaa accgaagagg
     2701 aactgattcg cgccttaatg ctgagtcatc tcactgtaat ctatattaaa caaagtttgg
     2761 gacgtctctc tgccttgtgt ggctgtgtag tagctgccac gggttccagt tgcggaatca
     2821 cctggctgat gggtggaaac tataatcagg tagcctttgc cgttcaaaac atgattgcca
     2881 acctgacggg aatgatttgc gacggtgcaa aaccgagctg cgcactcaaa gtaacaaccg
     2941 gagtctcaac agccgtatta tctgctatga tggcaatgga ggaccgttgt gtgacttctg
     3001 tagaaggcat tattgacgaa gatgtcgatc aaagcattcg taacttgaca agaatcggct
     3061 cgcaggccat gaacgaaacg gataagatgg tgcttgatat catgacgcac aaaggaggat
     3121 gttaacaggt aataagtaac aagtaataag taataggtaa tagctggaat aacggcataa
     3181 aaaaagtatt aagtattaac ttccgcctat atccgcatgg aattaatact taatacttat
     3241 tacctattac ttaaaattag tggcagtgtc cgccttcgca accgcagtca tcgccacagt
     3301 cgctgccgca gctgtcgcat ccgcaaccgc aaccttcacc gctcatcatc ttcaccagtt
     3361 cctgaatttc ttcgttggta gcaggacggc tttcgattac ttcaccttca aagatcaggt
     3421 cagcgcctgc caatgggtgg ttaaggtcaa ctactactac atccggtttg atttctacga
     3481 cgctggcgtt tacgcgttga ccgtctccgg tcatcaaagg tacaatgctg ccttctgtta
     3541 cgcgttcgct gtcgaacttg ccatctattt caaagatatt tttaggaaga tcaaatacat
     3601 gttgctcatc gtaggctccg taagcttcat ctgccggaat ggtaaaatcg aatttatcac
     3661 ccttagaaag agctgttatc tggttctcga agctttcgag cgttgtgcct aatcctgaaa
     3721 tgaactgaaa aggatgttct gcatttgttt cttcgaacaa ttctttttca ccatcttcca
     3781 ctgtatatag cttatatgca acggtgatgt acttgttttc tactgtttcc atctgatatt
     3841 tatagtttct aattaataaa tcccttattt agggtggaca aagatacgaa taatttgctt
     3901 gctaccgggt gcatacggag taaatttcag attattaagc gcttttgtca gaaatggaca
     3961 gtcattctct actaactgat agttgcaaat tcaaccttta agtgataaaa tttaggttta
     4021 ttgccgttct tttcttacga ttattcgctt tttagtgatt tttttcttcg atttgtttgg
     4081 agataataaa aaagccctta cctttgcagc acgaaaataa agaaaagaag atatgaatat
     4141 attacataca tctattaacc tagcagttct gcatattatt cgcgtcgtgg tggtgccatc
     4201 aagagcgtga gaaaggtttt gtgtatgtat tcgtaccata aaagatagaa tttggagcct
     4261 ttctcactga tgtgagggag gctctttaat taaaagatag attgaaatga aaaagcaatt
     4321 acgcagttcg tttagtacac aaggccgtcg catggcggga gcccgcgcat tatgggcagc
     4381 caacggcatg aagaaaaatc agatgggaaa acccattatc gctatcgtca attcgtttac
     4441 acaatttgtt ccgggacacg tgcacctgca tgaaatcggg cagttggtga aggcggaaat
     4501 tgagaagctg ggatgcttcg ctgcggaatt taatacgatt gctatcgatg acggtatcgc
     4561 tatgggacat gacggaatgc tttactcgct tccttcccgt gatatcatag cggacagcgt
     4621 agaatatatg gtcaatgcgc acaaggcgga tgcaatggta tgtatcagca actgcgataa
     4681 gatcaccccg ggaatgttga tggctgccat gcgcctgaat atccctaccg tattcgtatc
     4741 cggcggaccg atggaagccg gagagtggaa cggccagcat ctggacttga tcgatgccat
     4801 gattaaatcg gcggacgaca gtgtaagcga tcaggaagta gcgaatatcg aacagaatgc
     4861 ctgtcctacc tgcggatgtt gttctggaat gtttacggca aactcgatga actgtctgaa
     4921 tgaagctatc ggcttggctc ttccgggaaa tggcacaatc gtggctacgc acgaaaatcg
     4981 tacgagactg tttgaagatg ctgccaaact gattgtggaa aatgcaatga aatattatga
     5041 agaaggtgac gaaagtgtac ttccccgcag catagctacc cgtcaggcat tcctcaatgc
     5101 catgacgctg gatattgcga tgggcggttc taccaatacg gtgcttcacc tgttggccgt
     5161 ggcacatgag gcaggagtcg atttcaagat ggacgacatc gatatgctgt cacgcaagac
     5221 accctgcctg tgtaaagtcg ctccgaatac tcaaaaatat catattcagg acgttaaccg
     5281 tgcgggtggc atcattgcta tcctggcaga gttggcaaaa ggcggtctga ttgatacttc
     5341 cgttctccgt gtggatggca tgtcgctggc ggaagcgatc gatcaatatt caattaccag
     5401 cccgaacgtt acggaaaaag caatgagcaa atattcaagt gcggcaggaa acagattcaa
     5461 tctcgtactt ggttctcagg gagcttatta tcaggaatta gataaagatc gcgcgaacgg
     5521 atgtatccgt gatctggagc acgcctatag caaggacgga ggcctggcgg tactgaaagg
     5581 aaatatcgct caggacggtt gcgtagtaaa aacggcgggt gtagacgaaa gcatctggaa
     5641 gtttaccgga cctgccaaag tattcgactc acaagaagca gcctgtgaag gcatcctcgg
     5701 aggccgagtc gtcagcggcg acgttgtcgt catcacgcac gaaggtccga agggcggtcc
     5761 cggtatgcag gaaatgcttt acccgacttc ttatatcaaa tcccgtcacc tcggcaaaga
     5821 atgtgccttg attaccgacg gacgtttcag tggtggaact tccggattga gtatcggaca
     5881 cgtttctccc gaagccgctg ccggaggtaa tataggaaaa atagtagatg gagatatcat
     5941 cgaaatcgac attcccgccc gaacgattaa cgtgcgacta acagatgaag aactggctgc
     6001 ccgcccgatg actcccgtca cccgtgaccg ttacgtgccg aagagcctga aagcatacgc
     6061 cagcatggta agctctgccg ataagggagc agtgagatta atagactgat ccacttcatt
     6121 atccattatg aatcatccat tatccattaa agaactatga gtaaggactt aataacaggc
     6181 gcagaggcaa tgatgcgctc tctggaacat cagggagtga ctaccatttt cggttatccc
     6241 ggcggttcca tcatgcctac gttcgatgcc ctgtacgacc atcaaaatac attgaaccat
     6301 atcttggttc gccatgaaca gggagctgcc catgcggcac aaggctacgc ccgtgtatcg
     6361 ggtaaagtcg gtgtttgctt ggtgacaagc ggccccggag caaccaatac gatcacaggt
     6421 attgcagatg cgatgataga cagtacgcct atcgttgtca ttgcaggaca ggtgggaaca
     6481 ggctttcttg gaacagacgc ttttcaggaa gtcgatctcg taggtatcac tcagccaatc
     6541 gctaaatgga gctatcagat tcgccgtgcc gaagacgtag cctgggcgat agcacgtgct
     6601 ttctacattg ccagtagtgg tcgtcccggt ccggtggtac tcgactttgc caagaatgcg
     6661 caggttgaaa aaacaaaata cgagccgacg cagcaggagt ttatccgcag ctatgttccg
     6721 gttcccgata cagacgaaga atcagtaaag gctgccgccg aactgatcaa taacgccgaa
     6781 cgcccgcttg tcttggtagg acagggagtg gaactgggaa gcgctcagga agaactgcgt
     6841 atctttatcg aaaaggcgga tatgcccgca ggttgtacct tgctcggact ttccgcattg
     6901 cctaccgacc atccgttgaa taaaggaatg ctgggtatgc acggaaatct gggaccgaat
     6961 atcaatacta acaaatgtga tgtactgatt gctgtcggta tgcgtttcga cgaccgtgtg
     7021 accggtaatc tggctactta cgccaaacaa gcgaaagtga tccattttga cattgatccg
     7081 gcggaagtaa ataagaatgt aaaggtagac attgccgttt tgggcgactg caaaaagacg
     7141 ctggctgctg tgaccggact gctgaaaaag aaccggcaca ccgagtgggt cgatagtttc
     7201 aaggaatatg aagcggtaga ggaagaaaaa gtcattcgtc ccgaacttca tcctgcaacg
     7261 gattcactga gtatgggcga agtggtgcgt gcggtaagcg aagcgacccg tcacgaagcc
     7321 atattggtga cagatgtagg tcagaatcag atgatctctg cccgctactt taaatatacc
     7381 agggaacgta gtatcgttac ttcgggtgga cttggcacga tgggttttgg ccttccggca
     7441 gctatcggag ctactttcgg ccgtcccgac cgcactgtat gtgtatttat gggtgacggc
     7501 ggactgcaaa tgaacattca ggaactgggt acgatcatgg aacagaaagc tccggtgaag
     7561 attatctgcc tgaacaacaa ttatctcggc aacgtgcgcc aatggcaggc tatgttcttt
     7621 aatcgccgtt attcatttac tccgatgctg aatccggatt acatgaaaat cgcttccgcc
     7681 tacgatattc cttccaaacg tgtcttttca cgggaagaat tgaaagcggc catcgacgaa
     7741 atgctctcga cagacggggc gttcctgctc gaagcctgtg tggtagaaga aggcaatgtc
     7801 ctcccgatga cccctccggg cggttcagtc aatcagatgt tgctggaatg ttaatcctta
     7861 atttagaaag ttatgagtga taagacatta tatacgatta tagttcattc tgaaaatata
     7921 gccggattgc tgaatcaggt gaccgctgta tttacccgtc ggcaaataaa catcgagagt
     7981 ttgaacgttt ctgcttcttc cattaaagga gtacataaat atacgattac agcgtggact
     8041 gataaggaca ctatcgaaaa ggtggtgaag cagatcgaaa agaagattga tgtgattcag
     8101 gcgcactatt ttacggaaga cgagatttat ttccatgaga tagccttata taaggtatct
     8161 actcctgctt ttcaggagac tccggaagca tctaaagtga tccgcagata taatgcccgc
     8221 attgtagagg tgaatccggt attctctatc gtcgagaaga acggcatgag tgaagagatt
     8281 acttcccttt acgaagaact tcgggctttg aaatgtgtgc tgcaatttgt ccgttcgggc
     8341 cgtgtggcta ttactaccag ctgtttcgaa cgtgtgaatg agttcctgga cggacaggaa
     8401 gcgaagtata agcaaagtaa aaaggaacag gagtaatgag tgaagaaaat aaaataggga
     8461 cttatcagtt tgtggcagag ccgtttcacg tagattttaa cggccgcctg accatgggcg
     8521 tgctggggaa tcatctgctg aattgcgcag gttttcatgc cagcgaccgt ggatttggta
     8581 ttgctacgct gaacgaggac aattacacat gggtgctttc ccgtctggcg atcgagctgg
     8641 acgagatgcc ttaccaatac gagaagttct cggttcagac atgggtggag aatgtctatc
     8701 gtctctttac cgaccgtaac tttgccgtca ttgacaagga tggaaagaag atcggctatg
     8761 cccgttccgt atgggcgatg atcaatctga atactcgtaa gcctgccgat ctgttggcat
     8821 tgcatggagg aagcatcgtc gattatatat gcgatgaacc ctgcccgata gaaaagcctt
     8881 cgcgtatcaa ggtgacaagc aatcagcctg ttgcgacgct gacggcaaaa tacagtgata
     8941 tcgatattaa cggacacgta aacagtattc gttatatcga gcacatactt gacttgtttc
     9001 cgatagaact gtatcagacg aaacgtatcc gccggtttga aatggcgtat gtggctgaaa
     9061 gttatttcgg aaatgaactc tctttcttct gtgatgaggt gagtgaaaac gagtttcatg
     9121 tagaggtgaa gaaaaacggc agcgaggtag tatgccgttc caaagtgata tttgaataat
     9181 atagagtata aaatcaatta ataacagatg gcgcaagtca tcaaaacaaa aaaacaaaaa
     9241 aaatggcaca gttgaatttt ggcggaactg tagaaaatgt agttatccgt gatgaatttc
     9301 cattggaaaa agctcgtgaa gtattgaaaa atgaaacaat cgctgtaatc ggttatggcg
     9361 tacaaggtcc cggacaggct ctgaaccttc gtgataacgg tttcaatgta atcgttggtc
     9421 aacgccaggg aaagacatat gacaaagcgg ttgctgacgg atgggttccg ggtgaaactt
     9481 tgttcggtat tgaagaagct tgcgaaaaag gtacgatcat tatgtgcctg ttgtctgatg
     9541 cagcagtaat gtctgtatgg cctactatca agccttacct gactgcagga aaagctcttt
     9601 atttctctca tggttttgct attacatgga gtgaccgcac aggtgtagtt cctcctgcag
     9661 atatcgacgt aatcatggtt gctcctaaag gttcgggtac atccttgcgt actatgttcc
     9721 ttgaaggtcg cgggttgaac tcttcatacg ctatctatca ggatgcaaca ggcaacgcta
     9781 tggacagaac aatcgcattg ggtatcggta tcggttcagg ttatttgttc gaaacaactt
     9841 tcatccgcga agctacttcc gacctgacag gcgaacgtgg ttcattgatg ggagctatcc
     9901 agggtctgtt gctggcacaa tacgaagtgt tacgtgaaaa cggtcacact ccttccgaag
     9961 cattcaacga aactgtagaa gagctgactc agtcattgat gccgttgttt gcaaagaacg
    10021 gtatggactg gatgtatgct aactgctcta ctacagctca acgtggtgct ctcgactgga
    10081 tgggcccctt ccacgatgct atcaaaccgg tcgttgaaaa gttgtatcac agtgtgaaga
    10141 ctggtaacga agcacagatt tcaatcgact ctaactccaa accggattat cgtgagaaac
    10201 tggaagaaga actgaaagca ttgcgcgaaa gcgaaatgtg gcagactgcc gtgacagttc
    10261 gtaaacttcg tccggaaaat aattaatcag acttatacta tataagtttt tcaaaaggcg
    10321 ggaaaatcat cttttcccgc ctcttttatg tgtatgccac tcttttgaat gacagaataa
    10381 ggatgaaagt agcaaaaaag attaaaagat actgataata taggtgaaaa agagcattta
    10441 tgattacctt tacggcaaca aataaaacag aataggcaat gaagaaactt tttacttaca
    10501 gaaaatcgat acgtatgaag atgatttctt ctttaatgaa tagtatatca gaatgttaca
    10561 ttaaaagata tttaagttat tctctaccga atggtagctg taataccatt tcaagtcctt
    10621 tttatatttc gtgttccatt agtgattcgt tgatatgatg cagaatttta ttctgtagca
    10681 ggaaaaagta tgcgttaaat tgaatttaag acagagcttt tggaacagaa tttagtggga
    10741 aaataacatt gtttgttttg tttgtaaatg ggagtcttct ttcgtgagaa agggggcttc
    10801 tttttttatc ccgatgattc aggaggatac cgcttcctgc cggatatact gtatcagttt
    10861 ccggtagaac gcatgcttgg taagagtggt tgcatctccc aaaatcacaa gtttcatccg
    10921 ggcgcgggta atggctacgt tcattcgtct taaatcattc agaaaaccga tctgtccgtc
    10981 ctcgttcgcc cggacgaggc tgataaagac gacatcccgt tcctgtccct gaaagccgtc
    11041 taccgtgttg accgtgatga ggctgcggaa agggcggaga aaactgcttc ctctgatttt
    11101 acttctcagg tattgcactt gcgccttgta gggcgaaatc agaccaaagt cgatgctctc
    11161 gtccaggatg cgtgctttgc cgatccggct gatataggct tccagttctt gcagtaacaa
    11221 gttggcttcc tgcttgttga tgcgcccgaa gctctcgcct acaaactctt cgtggaagtc
    11281 catttccgag gtatctatcc agttcatggg agtgtcgaag tcaaggatac cccggttgcg
    11341 cacttccggt gcggcttcca gttctccgtt gtagaaccat tcggagggaa agcgcatgat
    11401 tgcctcgtgc atccggtatt gcactttgag cagcgagacg gcagaaggtt tttgctgcac
    11461 gactttttcc attaaagtat ggtccagtcc gccacgggcg gcttcgatac atttgattgt
    11521 aggagggagc tggcaatggt cgccggcaag aatcacacgg tcggcctttc ggatggcgat
    11581 ccaacaggcg gcttcgagtg cctgggcggc ttcatcgata aataaggtgg ggaaacgccg
    11641 tccgttgagc aaacggtgat tgctgctgac cagcgtggaa gcaatcacac gggcactgtc
    11701 gaaaagatcg gcgttgatca ggatttccag ttcggtggca cggtcgcgga ggcggctcat
    11761 ccggctgcgc attccttccc tttcggagta acttccccga cgcatccggc tgcccatttc
    11821 acggatcgat tttcggattc cccaaagttc ggggtaggcc gaatgattct caaagcggcg
    11881 ttcgtaagtg aaagaaagca ttttgtcatt aacacgtgta gggttaccaa tgcggaggac
    11941 aggcacaccc cggtctacca gtttctcgca aatccagtcc acagccgtat tactttgggc
    12001 gcagaccagc acctgcggtt cgcggtgaag cgtttcgtaa atggcttcca cgagcgtggt
    12061 agtctttccg gttcccggag ggccgtgaac gatggcgaca tcgcgtgtgc ataacacttt
    12121 gtttacggct gtttcctgcg tgctgttcag ccacgggaaa cggacgggat ataattcgcg
    12181 gaatcccggc ttttgtgttc ccagcaaggt gtcccggagt tcggcaaggc ggttgccctt
    12241 agcgcggatt gtgtcttcca gcgcttcgaa catggcacga taggacgttt catcgaaata
    12301 aagttgtaca cccagcacct cttccgtttg cagttccagc aaggcgcccg cactgggaag
    12361 cacgaccacc atccgttcgt cgtccgcata actcaccgtt gcaatgaaat tcatgtaatt
    12421 cacttttccg tcaaatgact gccggaaaaa gcagacggga cgaccgaatt cgaaggaatg
    12481 ctcgatttct ttattttcgg tgcgtgtaat atctattaca agttgattta gagaattata
    12541 gtaacttcga ccgggagagg cgggatacca gcacagacca cgtttcactt tgcgggcgac
    12601 acccattgtt tcagtctgcc gcttgaattc ctccttttcg tgttcatact ccatgcgtag
    12661 caggagttgc tgttgctgaa ggtcgatgat tggacttttc ggatgattat tcataataga
    12721 cgcaaaggta ataaatcttc ttcctgagac gaaaatatat ttcattttgt taaacattcc
    12781 tcgaacgccg ttcgttattt ttatagatag actaaaaaaa ataaaagcaa tatggtgtat
    12841 gatttgacta tgttagaggc tttttattct gcttataaag gaaaagtgga acacgtgcgg
    12901 gctgttttga aacgcccatt gacgttagcc gagaagattc tgtatgccca cctgttcaat
    12961 gagggcgatc tgaaaaacta caagcggggt gaagactacg taaatttccg tcccgaccgc
    13021 gtcgctatgc aggacgcgac tgcccagatg gcattgcttc aattcatgaa tgcaggaaaa
    13081 gaaaaagtgg ctgttccctc caccgtgcac tgtgaccact tgatacaggc gtacaaagga
    13141 gcaaaggagg acattgctac ggcaaccaaa acaaacgaag aagtttacga ctttttgcgc
    13201 gatgtatcct ctcgctacgg catcggcttt tggaagccgg gtgccggtat cattcaccag
    13261 gtagtgctcg aaaattacgc tttccccggc ggaatgatgg taggaaccga ctctcacact
    13321 ccgaatgccg gaggactggg catggtggcc atcggcgtcg gcggtgcgga tgccgtagac
    13381 gtgatgacag gtatggaatg ggaactgaaa atgccaagga ttatcggtgt ccgcctgacc
    13441 ggaaaactga gcggctggac ttccccgaaa gatgtcatcc tgaaacttgc agggattctg
    13501 accgtaaaag gaggcacgaa ctccatcatc gaatatttcg gaccgggaac agcttccctg
    13561 tcggctaccg gcaaagcgac catttgcaat atgggtgcgg aagtaggagc taccacttcg
    13621 cttttcccgt tcgacgggcg catggctact tatctgagag ccaccggcag ggatcgcatc
    13681 gtggaactgg cggaagccgt ggactgtgag ctccgtgcgg accaacaggt gacggacgaa
    13741 ccggaaaagt actacgaccg tgtcatcgac atcgatttgt
//
