LOCUS       gnlProkkaOELEJGKM_455  13334 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OELEJGKM_455.
ACCESSION   gnlProkkaOELEJGKM_455
VERSION     gnlProkkaOELEJGKM_455
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 09:22:36
            Original ID  :: gnl|Prokka|OELEJGKM_455
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13334
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13334
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3564:3831]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3565..3831
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13334
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13334
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2..655
                     /locus_tag="ctg455_1"
                     /transl_table=11
                     /translation="MFTCPEGRTKPWGTNHAVMMGADVIKEPFAVINCDDFYGRDSFQV
                     MGKFLAALPEGSKNVYSMVGFRIGNTLSESGTVSRGLCGTDANNLLTSVVERTKIQRMD
                     GEVKYIDDNGEWTATPETTPVSMNFWGFTPDYFAYSAEFFKSFLSDPKNMENLKSEFFI
                     PLMVDKLINDGTATCEVLDTTSKWFGVTYPEDRQSVVDKIQALVDAGEYPAKLF"
     CDS             complement(700..2370)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 277.6; E-value:
                     3.6e-84)"
                     /gene_kind="transport"
                     /locus_tag="ctg455_2"
                     /transl_table=11
                     /translation="MKKQQKDKKVKKDRREKLRYIREVSAEQRGRILLSCLTGILGVAF
                     ALAFIYATKRVIDTATGITDDNLTHIAVLTVVLLTAQLLCGAADTWISTRMQIETGNAL
                     RHRLFSRLLQSRWNELERFHTGDVVNRVEQDTTAIVTLLTSSVPAFIVTSIQLLAAFLF
                     FYFLDPSLPWLIVAILPVFLSGSRFYMRRMKRYTHDIRNSDGRIQSVIQESLQHRIVIK
                     TLEQGERHLDKLDDLQDMLHSQVMGRTRFSLSAHMLVALAFSGGYLTAFLWGAVHLSAG
                     CITFGTMTAFLQLVGKVQRPVFDLSRLIPSVVNALTAIDRLLELERLPAEADGDSIFLA
                     STPELELKDVTFRYTPDDRPVFSRFSCRFPAGSCIAIVGETGKGKTTLIRLLLALATPQ
                     EGQILLIPAKHPLETNHTVSPQTRKNFVYVPQGNTLFSGTIRDNLLMGNPQASQEAIYQ
                     ALQTATADFVFHLPDGVDSPLSERGGGLSEGQAQRIAIARALLRPGNILLLDEATSALD
                     PDTERLLIKNLRRDCAGKTCIFVTHHPAVAEACESIVRL"
     CDS             complement(2393..3556)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg455_3"
                     /sec_met_domain="NTP_transf_5 (E-value: 2.5e-46, bitscore:
                     148.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQHAFFSLVRSGLWGTPADRQLFRSVSPDDWETVYRMANSQALLA
                     LTFDGISSLPAELRPPRVLYLKWAARTAQIEQANKRLNQLLPELNTLYREAGLHPVLLK
                     GQGIGTNYRTPLHRQCGDIDIYLGKQGQPIANRLLLQQGAIVEGEASDKHASYSLKGVH
                     IENHRIILRLNSPLANRYFQQIIRKWYPQETDYALFSETGKEDSKAVSIAIPPATFNAL
                     YIFLHAFVHFLNSGIGLRQLCDWTCLLANRHKEIDATTLLRQLQDLGLLHAAQAFGYIA
                     VTRLGLPANRLPFPLEGTKQIGEQLLEDILSTGNFGQHDNRIKPRPKGYWAGKWYTFCR
                     ATRRCNELRQFAPYEALWYPVTLIGGTIAIQINRSKGVKDKKARTKK"
     CDS             complement(3565..3831)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg455_4"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.1e-13,
                     bitscore: 41.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5.2e-16, bitscore: 48.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIKQGFILHRIGDDYIIMQDGSSNVDFSKVISLNQTSAMLWQEI
                     ENKEFDTDSVTEALTSRYDVDNESARRDAQKFIDSLDREGIIE"
     CDS             complement(3844..4284)
                     /locus_tag="ctg455_5"
                     /transl_table=11
                     /translation="MKKSIPNEILLPEVARLIKEGHTVTITVRGNSMNPFLVDRRDRVT
                     LGDFTTEQLQPGVTVLARDLTERIVFHRIIRRNGDILILQGDGNLAQTEETDIGRVMGV
                     MTEAMRKDKRYTADGKVWKLYSYWWMKLNPARRWLLALFRRI"
     CDS             complement(4311..5237)
                     /locus_tag="ctg455_6"
                     /transl_table=11
                     /translation="MRIQILDYQVGPHTFRMVKPSDFNIFKALPSLIPFITTIDTTQKV
                     IFETEIDDDETTTKRTIAKTPDDICFNWEDADCIIRPLPHSSHLVSITPRKSGKNYWME
                     CNDNFRQCFIHLPACRTETPAPENETNFVLNNFLMMLYAFNAARHHTLLMHASVVATET
                     GKGYLFLGKSGTGKSTHTGLWLQQFSDCHLLNDDNPIVHVDSLGKQATVFGSPWSGKTP
                     CYRKESMTVGAFVRLEQAPQNEIEQERAAHAFATLLPSCSCLKQNKEIYNAIVATVTEL
                     ATLAPVYHLKCLPDREATELCRKTVEG"
     CDS             complement(5484..9062)
                     /locus_tag="ctg455_7"
                     /transl_table=11
                     /translation="MMKLRNLMQVACMATAALTAFSCSQEEFENSGWKGNITVNATFEG
                     AGTDTRTTVNDEYKILWQDTDALGLFCSNAESNYSNTKLEYASGAGQTSATFNGSKPSG
                     ETAVFSIYPYQQNMSVSGNTLTMTLPATLTNYNGSSNGPMYAKVTNPDNLSALSFKHMA
                     AMIKLTVNKIPAEATTFKIIASNNIAGTCTVDLTAADPILTVASNGSKEITASFTASND
                     IKSRNFYIPLPTGTYSSITAQLTNGSDKVYFTKTLNDKILGRRDILVVPPLDCVVVDAT
                     TPSALSTALADSKNLPQEAPTAATVTDIAVSGSFNTTSGSNDGIAIPVLQNSDINLTFN
                     TAPTTSTAAPLTLTDKTNTSVSAPAATATNSVSLAVPETTAEQEAPSVAITMPSTTVTL
                     AAVGNKATYNEVTATTAQQTLIINAGVTVKKLTVKGGNLKIYGKVEQLVHDAGDTTIYI
                     IKGTEASLPATIDSKFVVQSDVAVLKTAFANGEDFKLSADADITGQSVSVPAGKSVVLD
                     LNGYTLTADNSATGKIIVLGKMTLKDSSTEKKGKIVASQDYTAASYNGSLIEIAGEDAS
                     MTMESGNISAVRETPDSNGQYGVGVTDGGDFTMTGGKIEAGWFAVAGNGNYKTQNSIIN
                     ITDGELISTADYAVYLPQSGTTTISGGKVYGAAGGVCIQRGTLNVEGTALITSKGTGST
                     GNWGDGTGGLDCAAINVSGAYGIATVNIKGGTLIAEAKSLITEGTTYTPVINVTGGTFS
                     DPSALKYMKANANVNIKLTADKTCPGFKTTSGQTLTMDLGGKILTLADPTVGSTGTETN
                     SCQLLEGSNVTFKNGTLKSDNNKIMIQNYCNLTLDNMTVEDTNAQYVVSNNCGNISINN
                     TTINAGSNANQFAFDVCGYAKYTAGVTVTVSGTSVINGKVEISKSAGNTELMKLNITSG
                     TFNGDLKVDASVRTENAQSIISVSGGTFSDPSVLKYMATNATVDIKLLSNINIAKTKLA
                     TGYILNAANATANLNLNGHDIINSSETADATPFTQIFTVQNGTLNISGNGNVKCDASAT
                     AKDDGYRMVIEARGYGTVNIHGGSYYNTQKLNTQIDLIYARENGKINIYGGTFESGKYG
                     TPNNDTDGRYWVLNLKNTDKNTASIQVSGGTFINFNPANPNMDDNESYLVTGYEVTRDG
                     SVYTAAHKVGDGRKEYIVGQTSQENR"
     CDS             complement(9076..9291)
                     /locus_tag="ctg455_8"
                     /transl_table=11
                     /translation="MKQNTPDGREAYITPSIEVIKMENEGVIATSGEPYHPITRSYSGS
                     TSTHSYNSASSSDLEDLINDILTVEN"
     CDS             9340..9516
                     /locus_tag="ctg455_9"
                     /transl_table=11
                     /translation="MFVYPLFRPSHCPFPGYTTVTHVVCVYTIPLMGENHINIDVSILV
                     VIFREIFKVAKFE"
     CDS             complement(9656..9982)
                     /locus_tag="ctg455_10"
                     /transl_table=11
                     /translation="MKNCYGIDFRSWHKELRTREKTKQPPCKLPDRASRSLQGVLFKVY
                     QISVLILLKKILFSFFSVCLPLFIRHIAAMLLRKTSSKTMQTVTKYLKELSGVRSDNSP
                     NSYK"
     CDS             10848..11180
                     /locus_tag="ctg455_11"
                     /transl_table=11
                     /translation="MKQLIACCGLDCENCAARIATVNNDDELREKTAKEWSVLNNTPEI
                     TAETIHCMGCRADGVKFTYCSDYCAIRKCVYEKGFNTCGDCKELDTCQVVGAVLQHAPG
                     ARENLY"
     CDS             11415..12191
                     /NRPS_PKS="Domain: oMT (51-145). E-value: 2e-11. Score:
                     34.4. Matches aSDomain: nrpspksdomains_ctg455_12_oMT.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 81.3; E-value:
                     1.3e-24)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg455_12"
                     /transl_table=11
                     /translation="MSNENKTIHDFEFNLICDFFSNMERQGPGSPEVTLKALSFVDGLT
                     DESLIADIGCGTGGQTMVLAGHVPGQITGIDLFPGFIDIFNRNARQLGLQDRVKGIVGS
                     MDALPFGEEELDMIWCEGAIYNIGFERGLKEWRKYLKPGGYIAVSESSWFTDERPAEIN
                     DFWMDAYSEMDTLPNQVTKLYKAGYLPVATFILPENCWTEHYFASKVAAQEIFRKKYAG
                     NKIAEEFSLLQMIEDELYGKYKEFYGYVFFIAKKVG"
     aSDomain        11568..11849
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg455_12_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.00E-11"
                     /label="ctg455_12_oMT.1"
                     /locus_tag="ctg455_12"
                     /protein_end="145"
                     /protein_start="51"
                     /score="34.4"
                     /tool="antismash"
                     /translation="DIGCGTGGQTMVLAGHVPGQITGIDLFPGFIDIFNRNARQLGLQD
                     RVKGIVGSMDALPFGEEELDMIWCEGAIYNIGFERGLKEWRKYLKPGGY"
     CDS             complement(12266..13114)
                     /locus_tag="ctg455_13"
                     /transl_table=11
                     /translation="MNISEFNINDEFIACNHITTNELNPLVEKPYHTKASIFALCTKGV
                     LKTIINHTQFRVEANALLVIPPETFVQLLHTSDDAEIYVVIFSQQLIQSSGAGKVMMDK
                     FHIIGKHYIFPLSRTDFQLYAEFMTYLSHLYQRTESPSSLVSLQTLLTYLLQGISELCP
                     ERPRIKETPGSRHFNQYRIFIRLVHTDYVREHQVSYYALKMNMRPAALCRLVKKESGYT
                     AMEIINNTIIMDAKAQLCTANTPIKDIAVSLGFNNAAFFNKFFKRHTGIPPQKFRTSSK
                     Q"
     CDS             13268..13333
                     /locus_tag="ctg455_14"
                     /transl_table=11
                     /translation="MAKVNIQSCSYRRQSPVGGIKQ"
ORIGIN
        1 aggcttcacc tgccccgaag gccgtaccaa accttgggga accaaccatg ctgtaatgat
       61 gggtgccgat gtaataaagg aaccgtttgc tgttatcaat tgcgacgatt tctacggtcg
      121 tgactccttc caggtaatgg gcaaattcct tgcagccctt cccgaaggct ccaaaaacgt
      181 atattccatg gtaggcttcc gcatcggcaa tacgttgagc gagagcggta ccgtatcccg
      241 tggattgtgt ggaacggatg cgaacaacct gctgacttcc gtagtggaac gcaccaagat
      301 tcagcgtatg gatggcgagg tgaagtacat cgacgataac ggtgaatgga ctgccactcc
      361 cgagacgact ccggtcagca tgaacttctg gggtttcact cccgattatt ttgcttacag
      421 tgcagagttt ttcaagagtt tcttgagcga cccgaagaat atggagaacc tgaaaagcga
      481 attcttcatc ccgctgatgg tagataagtt gattaacgat ggcactgcta cctgcgaagt
      541 gcttgataca accagcaagt ggttcggtgt gacttatccc gaagaccgtc agagtgtagt
      601 cgacaagatt caggctttgg tggatgcggg cgagtatcct gcgaagctgt tctgagtttg
      661 ttaaccaaag gcagataccc gttggggctt attctctgat tataatcgga caatagattc
      721 gcatgcctcc gctactgccg gatggtgggt gacgaagata catgttttgc ctgcgcagtc
      781 tctgcgcagg ttttttatta acagccgttc cgtgtcgggg tcgagggcag aagtggcttc
      841 atctaaaaga agaatgtttc cggggcgtag cagagcgcgg gcaatggcga tgcgttgggc
      901 ttgtccttca ctgagtccac cacctcgttc gctgagtggg gagtctacgc cgtcgggaag
      961 gtggaagacg aagtcggcgg tggcggtttg cagggcttga tatatggctt cttgagaagc
     1021 ttgtgggttt cccatcagca ggttgtcacg gatagttccg ctgaaaaggg tattgccttg
     1081 cgggacatat acgaagttct tgcgggtttg cggagagacg gtatgattgg tttcaagtgg
     1141 atgtttggcg ggtatcaaga gtatctgtcc ctcttgtggc gttgccagtg ccaacaatag
     1201 ccggatgagc gttgtctttc cttttcctgt ttctccgact atagctatgc agctaccggc
     1261 ggggaaacgg caggagaagc ggctgaatac cggacggtca tcgggagtgt agcgaaaagt
     1321 cacgtctttc agttccagtt ccggggtaga ggcgaggaat atgctgtcac catccgcttc
     1381 tgccggcagt ctttccaatt ccaatagccg gtctatggcg gtaagggcat tgactacgga
     1441 aggtatcagg cgtgagaggt cgaacacggg acgctggact tttcctacca attgcaaaaa
     1501 ggcggtcatc gttccgaagg tgatacagcc tgcgctgagg tgaacggctc cccaaagaaa
     1561 agccgtgagg tatccgccgg aaaaggcaag ggccactaac atgtgggcag aaagcgagaa
     1621 acgggtacgt cccatgactt ggctgtggag catgtcttgc aagtcatcga gtttgtccag
     1681 atgccgttcg ccttgttcca atgttttaat cactatgcga tgttgcaggc tctcttgtat
     1741 gacggactgg atgcgaccgt cactgttccg aatatcatgt gtatagcgtt tcattcgtcg
     1801 catatagaaa cggctgcctg atagaaagac gggcaggatg gcaacaatca gccatggcag
     1861 tgaagggtct aaaaagtaga agaatagaaa ggctgccagc agttgtatac tcgtgacgat
     1921 gaatgccggg acagaagagg tgagcaatgt gacgatggcg gtggtgtctt gttctacccg
     1981 gttcactacg tctccggtat ggaaacgctc caattcgttc cagcggcttt gcagtaagcg
     2041 cgagaagagg cggtggcgaa gggcgttgcc cgtctctatc tgcatacggg tacttatcca
     2101 agtgtcagca gctccgcaca gtaattgggc agtcagcagg acaacggtga gaacggcgat
     2161 atgcgtcagg ttgtcgtctg ttattccggt agcggtgtct atcacccgtt tggttgcata
     2221 gataaaggct agggcaaagg ccacgcccag aatgccggtg aggcaactta gcaggatacg
     2281 tccgcgttgt tcggcagata cctctcgaat atacctaagt ttttcacgtc tgtccttttt
     2341 cacttttttg tccttctgtt gctttttcat tccttttatt ttccgggttc ttttatttct
     2401 ttgtccttgc tttcttgtct tttactcctt ttgatcggtt tatttgtata gctatcgttc
     2461 cccctatcag agtcacggga taccagagtg cttcgtacgg tgcaaattga cgcagttcgt
     2521 tgcagcgtcg ggtggcgcgg cagaaggtgt accactttcc tgcccaatat cctttggggc
     2581 gtggcttgat gcggttatca tgttgcccga agttaccggt agacaggatg tcttccaata
     2641 attgttctcc tatctgcttg gtgccttcca aggggaaagg aagccggttg gcgggcaatc
     2701 ccagtcgggt gacggcaatg tagccgaatg cttgtgcggc atgcaatagt ccgaggtcct
     2761 gcaactggcg aagcagggtg gtggcatcta tttctttgtg gcgattggca agcagacaag
     2821 tccagtcgca tagctggcgc aggccgattc cgctgttcag gaaatgtaca aaggcatgca
     2881 ggaagatata aagtgcattg aaggtggccg gaggtatggc gatactgacg gccttcgagt
     2941 cctctttccc ggtttcggag aatagggcat agtctgtttc ctgcgggtac cattttctga
     3001 taatctgctg aaagtaccgg ttggcaagcg gactgttcag ccggaggatg atgcggtggt
     3061 tctcgatgtg tactcctttc aaactgtagc tagcatgctt gtcggacgct tctccctcga
     3121 ctatggcgcc ttgttgcagc aggaggcggt tggctatggg ttgcccttgt tttcctaaat
     3181 agatgtcgat gtctccgcat tgccggtgca agggagtgcg gtagttggtg ccgatgcctt
     3241 gccctttcag cagtacggga tgcagcccgg cttcccggta aagggtattg agttcgggca
     3301 gaagctggtt gaggcgtttg ttggcttgtt ctatctgtgc agtccgggca gcccatttca
     3361 gatagaggac gcgtggaggg cgcagttcgg ccggcagact gcttatgccg tcaaaagtca
     3421 gtgcaagcag ggcttgtgag tttgccatgc ggtacacggt ttcccagtcg tccggcgaga
     3481 ccgaccggaa gagttgtcgg tctgccggag tgccccacag gccggagcgt accaatgaaa
     3541 agaaagcgtg ttgcatatcc gtccttattc tatgattcct tcgcggtcaa gggagtcgat
     3601 aaacttctgc gcatcgcgac gggccgattc gttatctaca tcatagcggc tggtcagggc
     3661 ttctgtcacg ctgtctgtat cgaactcttt gttttctatc tcttgccaaa gcatggcgga
     3721 agtttggttc aggctgatga ctttgctgaa gtccacgttc gacgagccgt cttgcatgat
     3781 gatgtagtca tcgcctatcc ggtgcaggat aaatccttgt ttgattttca tggttatttt
     3841 gttttatatt cttctgaaca gggcgagcag ccagcggcga gcggggttta gcttcatcca
     3901 ccagtaggag tagagcttcc agactttgcc gtcggcggtg taccgtttgt cttttcgcat
     3961 ggcttcggtc atgacgccca ttacccgtcc gatgtcggtt tcttcggtct gggcgaggtt
     4021 gccgtcgcct tgcaggatga gtatgtctcc gttccgacgg atgatgcggt gaaagacgat
     4081 gcgttccgtc aggtcgcgtg ccagtacggt gacgcccggt tgcagctgtt ctgtggtgaa
     4141 atcgcccagt gtcacccggt cacggcggtc cactaagaaa ggattcatgc tgttgccccg
     4201 cacggtgatg gttactgtat gtccctcttt gatgagacgc gccacttcgg gaagcaatat
     4261 ctcgttggga atgcttttct tcatcggctg ttcagttcat cattcataac ttatccttct
     4321 accgtctttc tgcaaagttc cgtcgcttca cggtcgggta ggcatttcag atgatagacg
     4381 ggtgccagcg tggcaagttc cgtcacagtg gcgacaatgg cgttatagat ttccttgttc
     4441 tgctttaggc aagagcagga ggggaggagg gtggcgaaag catgtgctgc tctctcttgc
     4501 tctatttcat tctgcggtgc ttgttccaag cggacgaagg cgcctacggt catggattct
     4561 ttccgatagc aaggtgtctt tccgctccac ggagaaccga aaacagtggc ttgcttgccg
     4621 aggctgtcca catgtactat cggattgtca tcgttcagta gatggcagtc cgagaactgt
     4681 tgcagccaga gcccggtgtg cgtacttttg cccgtgccgc ttttccctaa gaagaggtag
     4741 cctttgcctg tttcagtagc gacaaccgag gcatgcatca gcagtgtatg gtggcgggcg
     4801 gcattgaagg catagagcat catcaagaag ttgttcagta cgaagttcgt ttcgttttcc
     4861 ggagccggtg tttctgtcct gcaggccggt aggtggatga agcattgcct gaagttatcg
     4921 ttgcactcca tccaatagtt tttcccgctt ttccgtgggg tgatggatac aaggtgtgag
     4981 ctgtggggca aagggcgaat gatgcaatcg gcatcttccc agttgaaaca tatatcatcg
     5041 ggagttttcg ctatggttcg ttttgtcgtt gtttcgtcat cgtctatctc tgtttcaaag
     5101 attacttttt gcgtcgtgtc tattgtcgtg atgaacggaa tcagtgaagg cagcgccttg
     5161 aatatattga agtcggaagg tttcaccatg cgaaaggtgt gcggtcctac ttgataatcc
     5221 aatatctgta ttctcatatg ttttgattgt tagttgttat tcatgatact ttgggctact
     5281 cagaaaaata atgaatgttt gtgtgaatga ggaagatttg agagattttt caactgtctt
     5341 gttgtcattc tttagacgcg gaggacgcag atctataaaa gaaaatccgc tgtccgccgc
     5401 atctaaaaga tagtaataag gcgattccga tatctcttcg tttggtttgc gaggatatat
     5461 tgcttccttt cttagaattt ggcttatcgg ttctcctgac ttgtttggcc aacaatatat
     5521 tctttcctcc catcaccgac tttgtgggct gctgtatata cactgccgtc acgggtaacc
     5581 tcgtagcctg ttaccaaata ggactcattg tcgtccatat tcggatttgc cgggttgaaa
     5641 ttgatgaacg ttccaccgga cacctggatg ctggcagtgt tcttgtctgt attctttaag
     5701 ttcagtaccc agtatctgcc atccgtgtcg ttgttgggtg taccatattt gccggattca
     5761 aatgttcctc catagatatt gattttccca ttctctcttg cataaatcag gtctatctgg
     5821 gtgttcagtt tctgggtgtt atagtaagaa ccaccatgaa tatttactgt cccgtatcct
     5881 cgggcttcaa ttaccatgcg ataaccatcg tctttcgctg tagcagatgc atcgcacttc
     5941 acattgccgt tgcctgaaat gtttagtgtt ccgttctgta cagtaaagat ttgtgtgaaa
     6001 ggagtggcat cagctgtttc tgaggaattg atgatgtcgt ggccattcag gtttaagttt
     6061 gccgttgcgt ttgcagcatt caatatgtag cctgtggcaa gcttcgtctt ggcgatgttg
     6121 atatttgaga gaagttttat atccacagtt gcgttggttg ccatgtactt cagtacgctt
     6181 gggtcggaga atgtacctcc ggaaacagag atgatacttt gggcattttc ggttctcacg
     6241 gatgcatcta cctttaagtc accgttgaaa gtaccgcttg tgatattcag cttcataagt
     6301 tcggtatttc ctgcactctt ggaaatttcc acttttccat tgatgacgct cgtaccgctt
     6361 accgtaaccg tgactccagc agtgtacttt gcatagccgc atacgtcgaa tgcaaattga
     6421 ttcgcattgc ttcctgcgtt gatagtggta ttgttgatgc ttatgttgcc acaattgttg
     6481 cttactacgt attgggcatt tgtgtcttct actgtcatat tatctaatgt caggttgcag
     6541 tagttctgaa tcatgatttt gttgttgtca ctcttcagcg ttccgttctt gaaagtaacg
     6601 tttgaacctt cgagtaattg acagctgttc gtttcggtgc cggtggaacc tacggtcggg
     6661 tcagcaagtg taagaatctt gccgcctaag tccatcgtca aggtttgtcc gcttgtggtc
     6721 ttgaatcccg ggcaggtctt gtcggcggtc aactttatgt tcacatttgc atttgccttc
     6781 atgtacttca gcgcgcttgg gtcggagaat gtaccgccgg taacgttgat gaccggtgta
     6841 taagtggtgc cttctgtgat gagtgacttt gcttcggcaa tcagtgtacc gcctttgatg
     6901 tttactgtgg caatgccata tgctccactt acgttgatgg cggcgcagtc cagtcctccg
     6961 gtaccgtcgc cccagttgcc ggtgctacct gtgcctttac tggtaatcaa ggctgtacct
     7021 tccacattca gagtgcctcg ttggatgcat acacctcctg cggcaccata aaccttgccg
     7081 ccactgatgg tcgttgtgcc ggattggggc agatagactg catagtcagc agtagaaatg
     7141 agttctccgt ctgtgatgtt gatgatggag ttctgcgtct tgtaattgcc gttgcctgcc
     7201 actgcaaacc atccggcttc tatcttgccg cctgtcatgg tgaagtctcc accgtccgtc
     7261 actccgacgc catattggcc gttactgtcc ggagtctctc tgactgcact gatgttgccg
     7321 ctttccatgg tcatggaggc atcttcaccg gctatttcaa tcagactgcc attataagaa
     7381 gccgctgtat aatcctggct ggcaactatc ttgcctttct tctcggtaga gctgtccttc
     7441 agtgtcatct tgcccaagac gatgattttg cctgttgcgc tgttgtcggc agtcagtgta
     7501 tatccgttca agtcaagaac cacggacttt ccggcgggta cactgacgct ttgccctgtg
     7561 atgtcggcat cggcggacaa tttaaaatct tcgccgttgg cgaaagcggt ctttaggact
     7621 gccacgtcgg attgaactac aaatttgctg tcgattgttg ccggaagtga tgcttcagtt
     7681 ccttttatta tatagattgt ggtatcgccg gcatcgtgta ccaattgttc tacctttcca
     7741 tatatcttca agttaccgcc ttttacagtc agcttcttta cggtgacgcc tgcattgata
     7801 atcaatgtct gctgggcggt agtggcagtc acttcattgt aagtggcttt attgcctact
     7861 gctgccaatg taacggtggt gcttggcatg gtgatggcta cagaaggagc ttcttgctct
     7921 gctgtggttt ccggtacagc caaggataca ctgttggtgg cagtggcggc gggagcactt
     7981 acgctggtat tggtcttgtc ggtcagcgtc aacggagcgg cagtactggt cgttggggct
     8041 gtattgaacg tcaggttgat gtccgagttc tgtaaaaccg ggatggcgat gccgtcgttg
     8101 ctgccagaag tggtattgaa gctgccgctg actgcaatgt cggttacggt tgctgctgtc
     8161 ggtgcttctt gtgggagatt ttttgaatca gctaaagctg tactaagcgc actgggggtt
     8221 gtagcatcta caacaacgca atccaaagga ggtactacca atatgtctct tctccctaag
     8281 attttgtcat taagcgtctt ggtaaaatat accttgtcgc ttccattcgt cagttgggca
     8341 gtgatggaac tataagtacc tgtgggcaaa ggaatgtaga agttgcgcga ttttatatcg
     8401 tttgaagcag tgaaggaggc agtgatttcc ttgcttccat tgcttgctac cgtcagtatc
     8461 gggtctgctg cggttaagtc taccgtacaa gtacctgcaa tgttattgga ggcaataatc
     8521 ttgaaagtag tggcctctgc cggaatcttg ttgacggtca gttttatcat ggctgccatg
     8581 tgcttgaagg acagagcgct cagattgtcg ggatttgtca ccttggcata catcgggcca
     8641 ttgctgctgc cgttataatt tgtaagcgtg gcaggtagag tcatggtcaa tgtattgccg
     8701 cttacgctca tgttttgttg gtaaggatag atggagaata cagccgtttc tccgcttggc
     8761 ttgctgccgt tgaaagtggc ggaagtttga ccagcaccgc ttgcatattc taattttgta
     8821 ttgctataat tactttctgc attactacag aacaacccta gggcatcggt atcttgccat
     8881 agaatcttgt attcatcgtt tacggtagta cgggtgtcgg tacctgcgcc ttcaaacgtt
     8941 gcgttaacgg tgatgtttcc tttccacccg ctgttttcaa attcctcttg gctgcaactg
     9001 aatgcggtca aggcagcagt tgccatgcag gcaacttgca taaggtttct taatttcatc
     9061 ataatgaagt cccccttagt tttctacggt taagatgtca ttgattaggt cttccaagtc
     9121 gctgctggat gccgaattgt agctatgggt agaggtgctg cccgaatagg agcgcgtaat
     9181 gggatggtaa ggttcgccgc ttgttgcaat gactccttca ttctccattt tgataacttc
     9241 gatagacgga gtgatgtatg cttctctacc gtctggtgtg ttctgtttca tatacacaaa
     9301 ttatttaaag gttaaacaat aaaaaaaacg tgagtaacta tgtttgtata tcctttattc
     9361 aggccttcgc attgcccttt ccctggatat acaacagtca ctcacgtcgt ttgtgtatat
     9421 accatccccc tgatgggaga aaaccatata aacatagacg tgagcatcct tgttgttatc
     9481 ttcagggaaa ttttcaaagt tgcgaagttt gaataaagaa gataatttca ataatgctct
     9541 tactaatatg taaataaacc cactacgcta tagcggattt gtgacaaaga taattgtttt
     9601 ttgtttaagt gtatctatgt ttctctattt tttttgggaa aggctcacgt ctctttcatt
     9661 tataggagtt aggagagtta tcacttctaa ctcccgataa ctccttcaaa tatttagtaa
     9721 ctgtctgcat tgtctttgag gatgtttttc tgaggagcat agcggctatg tggcgaataa
     9781 agaggggaag acagaccgaa aagaagctga ataaaatctt tttaagcaaa attaaaacag
     9841 agatttgata tactttaaac agaacaccct gcaaactccg gcttgctctg tccggcagtt
     9901 tgcagggtgg ctgcttggtt ttctcgcgtg tacgtagctc cttatgccac gaacggaagt
     9961 cgatgccata gcaatttttc ataataagac tttccatatt tttgcaaatg tccgtactgc
    10021 ctttggctga aacaatttat ataagtaatt gaagtttcgt aagtgagtat gcctgctgat
    10081 aaatgggaat ttatcgcaca gagcgcgaag cctgctctca taacctatgg agagcacgag
    10141 tgaaagcttg tggattttta tctaaaacat aggtattcct ttactcttct ccctttgttt
    10201 gtctgctgtg gcatagggaa tttatgacgc ctaacggcca tgaacaaccc tgctttcgac
    10261 cataaagcaa tcgtttgacg accgtaagca gagttgttca tggccgttag gcgtcactaa
    10321 ctccagagct attacagatg aagtacgtag cccgaaccta ttgcgcacaa ggcgcaaacg
    10381 tattatacaa cggtgtaaaa gacattagag tgcattattc atagtcggcc tttgattccc
    10441 gataactcct actatgctcc tacagtccaa ctccatatcc gttgacttca cagtaaggac
    10501 aagcccgaaa atgcaggaaa accgaacctg ccgattcatg taatctgcat gcagtattat
    10561 gctaggggat agcagcttac tgcaaaactc aggcgtttca ggcaggtgga agcaaatttt
    10621 gcttccacct tttcaggttg cttccatcgc agggcaaatg ccgatggaca gggggatgca
    10681 ggaggtgggt ggaagtgtgg aagcaaagtg atggaaaatt aatttggcat tcacacaata
    10741 ataaccgtat atttgtagca tggctgtctg cctcctctta aattcagata aagaggaggt
    10801 agacaaatgc ttgctatgag aaacacataa atggttataa ccaagtgatg aaacaattaa
    10861 ttgcatgttg cggactggat tgcgaaaatt gcgccgcccg tatagccact gtcaataatg
    10921 acgatgagct gagagagaaa accgccaaag agtggagtgt gctgaacaat acgccggaaa
    10981 ttacggcgga aaccatccat tgtatggggt gccgtgcaga cggggtgaag tttacctatt
    11041 gcagcgatta ttgtgctatc cgcaaatgtg tgtacgaaaa aggtttcaat acttgtggcg
    11101 actgtaagga actggatact tgccaggtgg taggtgcggt tcttcagcat gcgcccggtg
    11161 caagggaaaa tctttattaa ccgtaaaatc tttgattaaa taaaatattg cttatctttg
    11221 cagtatgaca aagacattta aatcggattt ggttttgtaa acaatctgtg ttccatgcac
    11281 agattgtccc ctttcgttta ctttcggata acttctttcg agagtgtttt tctattgtta
    11341 taattcaagt ttaatccgca tattatgctg aaggtgttgt gatactttcc gtatatgcaa
    11401 aatatagtaa gaaaatgagt aacgaaaata aaactatcca cgatttcgaa tttaatttaa
    11461 tctgtgactt tttctccaat atggaacggc aaggccctgg cagtcctgaa gtgacgttga
    11521 aggcattgag ctttgtagac ggtcttaccg atgaatccct tattgccgat atcggttgtg
    11581 gaacgggtgg tcagacaatg gtattggctg gccatgttcc gggacagatt accggaattg
    11641 accttttccc cggctttatt gacatcttca accgtaatgc aaggcagttg ggcttgcagg
    11701 acagagtaaa aggaattgtc ggttcaatgg atgccctccc tttcggtgag gaggagctgg
    11761 atatgatttg gtgtgaaggt gctatctata acatcggctt tgaacgtggc ttgaaggagt
    11821 ggcgtaaata tctgaaaccg ggagggtata ttgccgtatc cgagagttca tggtttacgg
    11881 acgaacgtcc tgcggaaatc aatgacttct ggatggacgc ctattctgaa atggatacac
    11941 ttcccaatca ggtgaccaag ttgtacaagg caggttatct tcccgttgct acattcattt
    12001 tgccggagaa ttgctggaca gagcattact ttgcttcaaa ggttgcggct caggagattt
    12061 tccgtaagaa atatgccggt aataaaattg ccgaagagtt cagcttactc caaatgattg
    12121 aggatgaact gtacggcaag tataaggaat tttacggtta tgtgttcttt attgccaaga
    12181 aggtaggctg atgacggact tctcttattg aggaatgcgg gtattctcag gacagaatat
    12241 ccgcattttg ggttttgagt agattttatt gttttgagga tgtacggaac ttctgaggag
    12301 gtattcccgt atgacgttta aagaatttgt tgaagaaggc cgcattatta aaacctagac
    12361 tcacggctat atcctttatc ggagtgttgg cggtacaaag ttgtgctttg gcatccatga
    12421 tgatagtatt gttgatgatt tccatggctg tatatcctga ttcctttttg acaaggcggc
    12481 aaagagctgc cggtctcata ttcattttca atgcataata ggacacttga tgctcccgga
    12541 catagtctgt gtgtaccaat cggataaaaa tgcggtattg gttgaaatgc ctgctgcccg
    12601 gagtctcttt tattctaggg cgttccggac agagttcgga tataccttgt aacagatagg
    12661 tcagtagagt ttgcaatgaa actagacttg aggggctttc tgttctttgg tagaggtgtg
    12721 acaaataggt catgaactcg gcataaagct ggaagtccgt tctcgataga ggaaaaatat
    12781 agtgtttgcc tataatgtga aacttatcca tcatgacctt gccggcccct gaactctgga
    12841 taagttgttg ggaaaatatg acgacatata tttcagcatc gtctgacgtg tgtagcaatt
    12901 gtacgaaggt ctcgggagga ataactagga gggcgttagc ttcaaccctg aattgagtat
    12961 ggtttatgat agttttcaga actcctttgg tgcatagagc gaagatactg gccttggtgt
    13021 ggtatggctt ttccactagc ggattcagtt cattggttgt gatatgattg caggcaatga
    13081 actcgtcatt tatattgaat tcggatatat tcatgttgga gattttaaga cgcaaaaatg
    13141 ggggataata atgtataaat gacagaggta acagttaaaa tcaatattac gctcaactta
    13201 tctctgttaa ataaggtaaa gttgtgaata atagaatata agtaactaat caaaattaag
    13261 cagcataatg gctaaagtta atattcagtc gtgttcctat cgccgccaaa gccctgttgg
    13321 tggcataaaa cagc
//
