LOCUS       c00024_gnlPro..        14690 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DDDCDFAK_24.
ACCESSION   c00024_gnlPro..
VERSION     c00024_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 22:47:43
            Original ID  :: gnl|Prokka|DDDCDFAK_24
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 5514
            Orig. end    :: 20204
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14690
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[15514:18742]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13228
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14690
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14690
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             167..787
                     /locus_tag="ctg24_7"
                     /transl_table=11
                     /translation="LLWLYILLGIVLFIALVMFIPITLRASYKEKFWCAVYIGFVKLQL
                     VPAKPKKEKKKKKAKKQTQKTEQPKKATEKKPSLIKKYGIEWLLNLIKKVAELAVSALQ
                     DFFSHILVKKLSLSISVAGDDAADTAIKYGKYCAVVYPAVGTIVRVVKCKGYGVDINPN
                     FSEKAETEINFDFAARIFAFRLIGLAVKHGIKGIKLLAEVKND"
     CDS             842..1237
                     /locus_tag="ctg24_8"
                     /transl_table=11
                     /translation="MDTTMEKIKEMIDVNTIIGEPITSPDGTLIIPVSKVSYGFAAGGS
                     DLPTKKENKDCFGGGSGAGVTIQPVAFLTVYQGDVRLVSVDREEGTADKLVNMIPDVLK
                     KVKGVFKKDKSESADDFSEITQDDIDG"
     CDS             1289..2413
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_9"
                     /sec_met_domain="Peptidase_S11 (E-value: 1.2e-58, bitscore:
                     188.7, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIILLAVCFVMPFVLMGAKTAEDTPPTTSAQAFVLYCPDNNTV
                     ICSKNADEKMKPASTTKIMTSLITLEEAASCNSEVTFKQKMVAEGSSMYLKVGEKVRFS
                     DLASGMMMASGNDAANAAAYTISGSPEKFSQRMNEKAKQIGMTNTNFVTPSGLDDDNHY
                     SSAKDMALLMSYALENDDFANLTAKKSVTVEFLEPKSKKTAYANHNRLLSLYPYCTGGK
                     TGYTTAAGRCLVSSAKKDGVTLVCVTLNDRNDWNDHISLYDYAFEKYRGVDCKDADFCA
                     DIPCVGGDKDSVTVTGEKNNTIVLKREDCDKIKKKIFIDSFLYAPIEKNESVGRIEYTL
                     GGKLLYKCNIVAGEKIKSDKKSVSIFSAIGNLFS"
     CDS             2457..3206
                     /locus_tag="ctg24_10"
                     /transl_table=11
                     /translation="MAKIEPIRLQKFIAQCGIASRRKAEELILGGHVKVNGKTAILGDK
                     VLPTDKVFVRGKRIVVPKGGNYRYIMLNKPRGFITTMNDERGRKCVAQLVENVGERVYP
                     IGRLDKDSEGMLVFTNDGDFANKVMHPKNNVYKIYRVTVRPSIDEDQLVKLETGVELDG
                     RKTAPAYVHVIHKEQGRVVLEMILHEGKNREIRRMCEAVGLEVARLKRTQIGGVKMGML
                     KQGDWRDLTEQEVKKLLANPFLNGKQL"
     CDS             3416..4750
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CT_Vparvula"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_11"
                     /sec_met_domain="CT_Vparvula (E-value: 1.6e-76, bitscore:
                     248.2, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLEDFKMSIEKINQAKAEIAATSAYKTITAFFDADSFCEIDAFA
                     KSGEGFAEVVAGFGTVEGMPVYAFAQNSDICGGAMSKAQAAKLKKLYGLALKTGAPVVG
                     FYDSVGGRLNQGTELLAGCGDVLNAAASLSGVVPQISVVLGTCLGTNALNAASADVVIM
                     SKDAQLSLSVTGKHSDAAYNAENGIASIVCDDADKAIKAAKELILYLPSNNLTMAPQSF
                     EEAPAEDGCGCVVSRTVDGNSIVKLFNDYGKEANVRFARLGGQVVGIVVTKGNELGCKS
                     ANKVAKFVRFCDAFSLPVVTFVNCPGFESIKSATKASAAYAEATTVKISVVTGKAIGSG
                     YVALAGTGANADVVYALPDAVISPVNVEAAAFIMAPEVMNVATDKQAEVAQKFADENLS
                     AYNAAQNGYVDGIVEEAQLRQTLISALDMLSGKRVSTLSKKHSTI"
     CDS             4789..5154
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 65.7; E-value:
                     8.2e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_12"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.5e-21, bitscore:
                     65.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLRITVNGTAYDVQVEELGGSSAPAAAAPAPAAAPAPAAKPAA
                     PAGAQGSVVVKAPMPGTVVNVVVSAGQAVKAGDDLVFIEAMKMETPVKAPQDGTVATVD
                     VAKGESVDSGKVLVTLN"
     CDS             5185..6588
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PYC_OADA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_13"
                     /sec_met_domain="HMGL-like (E-value: 1.5e-49, bitscore:
                     159.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 3.7e-55, bitscore:
                     177.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKIRVTETALRDAHQSLIATRMTTEEMLPVLDKLDKIGYYSLE
                     CWGGATYDSCLRFLNEDPWDRLRTIREHCPNTKLQMLFRGQNMLGYRHYADDCVEYLVQ
                     RSIANGIDIIRIFDALNDIKNLKTAIKAANKEGGHAQVAISYTTGPVFTDEYYVEYAKR
                     IADAGADSICIKDMAALLTPTRTESLVKAIKAAVPELPLQLHTHYTSGLASMCLLKGVE
                     AGADGIDTAISPLALGTSHAPTESMVAALSGTEFDTGLDLKQFSDIRAYFMTLREKYIK
                     SGLLDPKMLATDANALIYQVPGGMLSNLLSQLKQAGKEDKLDEVLAEVPRVRKDSGYPP
                     LVTPTSQIVGTQAVFNVITGKRYSMCTNEFKGLVAGEYGTTPMPIDPAFQKKIIGDKKI
                     IKGRPADQLKPELDKLRGEIEQWIEQPEDVLSYAQFPKVALDFFEKRRNAKVGINGDKL
                     DKKNMVHPV"
     CDS             6783..7790
                     /locus_tag="ctg24_14"
                     /transl_table=11
                     /translation="MKKLLTALIAFVMCFSVVTTAFAATPDETSDSDLISDIKQAMLDT
                     YYGDEKPEYLNVEILLDDEDEVYFSFSDSFATSANRVYTEAGNYIVSYLENCPVALYKN
                     NRVYMIPDAYNSGIIDDDTLEGLTYCGHMDIVPKSDDSALVIEIKNKVIEECFDGKSPE
                     TLRIDIVGRTSDGGVCFRYSFGGGMDVIVEETIGDYTYSYNHGDDVMLYKNGNVYSIKE
                     AYESGVIDDSILEELSKMNFGLKSNKPNTTVSTEPTTTVATVDEPVTVPDTTSATSATK
                     PVSTSDTATKDTPNNSQNNSGAVQTGQNSVAVILLVAMLAGCAVIFAKRRNHFE"
     CDS             8240..9823
                     /locus_tag="ctg24_15"
                     /transl_table=11
                     /translation="MVDTTSTSYIDKDVSSGRNYTYTVRCISADGKSFTSGYDSKGTSV
                     KYVAAPEISKLENVNGGVKISWGKVSGATKYRVYYKGSKGWTKMVDTTSTSYIDKDVSS
                     GRNYTYTVRCITSDAKKFTSGYNPTGKSVKYVATPKISKLEVTYDGVKLTWNKVAGAEK
                     YRVYYKDRNGWTKLADTTGTTMLDMNVVSKEFDLSIDDIYYTVRCISNDAKSFTSGYDS
                     KGTPIGDHQDCPEIYSIGAVNNGVEMHWTGDAPKFRVYIKENGSWKRIAETYDNYYVHK
                     GAKSGSNTYTVRGVSKDGKKFTTMFNPTGVTYRYKTSDKTRDAYINYMMNHQSEWMPSL
                     GSNHNLSGVMFLDFDFDGVPELVAQKADSNEYSFHSVVYKFEDGKLKRVGNVNDGFAIY
                     YNKTAKKYEVHDLKISLNVDDGYYWSGNSIITYDGENLFANMYSARGVGEESNNNIYYN
                     YFDGNDKNISRAKYNEINLKQFNNCVNAHMFTQFIATGYGDASVWGENTTAENKQSLLD
                     AYNSFSYEKY"
     CDS             complement(10001..11041)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_16"
                     /sec_met_domain="IlvN (E-value: 1.2e-83, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 9.1e-61, bitscore: 194.7,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKLAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(11102..11593)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_17"
                     /sec_met_domain="ALS_ss_C (E-value: 2.6e-30, bitscore:
                     94.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQDPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRINTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             complement(11606..13228)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_18"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.1e-43, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKVYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             complement(13425..14474)
                     /locus_tag="ctg24_19"
                     /transl_table=11
                     /translation="VDTLNLYGLFKQIDNGFIYSKINKDSPNEMEYYRYYLDKKNSVKL
                     GSIKNWYMQIHDKAYVNNHLCFTASTGDITDEENRTLEFIDIDLNKNKMTTVFSDKGGF
                     PYDTVTGADNLVIITKVLDNGTSLELYDTETQKFKQLKYLEFDDKNSIGETIRKVSIDK
                     STKTISLLVLDCISQNEASLKIETYDYDMNFQKSYDISNISDDSNELIQGVQVFDFKNN
                     YLFYQNFSITRCIGYIDSDKLKKSDISEDVDDTFSIVSASEDDSDTNLLYKRAESSSEN
                     NYIYLFDTTNKTMKETKFNIEEKGYTIGGISRIGKDNLMIMMSPDNADKKSDLNPRIYF
                     TKLSDLKFQ"
ORIGIN
        1 aacatttcaa gtcttgacga actgcctccg ctccccgaga gtgaagagga caaggagtcc
       61 gaagaaaacg gtgaagaaca ggaaaagact gaaaacggca acgagcagat tgatttgttt
      121 gccgatcagc ctgttgacag gcagtaaaat ttagggggaa ttccctttgc tttggctata
      181 tatcctactc ggaattgtgc tgtttattgc gcttgtgatg tttattccga ttactttgcg
      241 tgcatcatat aaagagaagt tttggtgcgc tgtgtatatc ggatttgtaa agcttcagct
      301 tgtgccggca aaacccaaaa aggaaaagaa gaagaaaaaa gcaaaaaaac aaactcagaa
      361 aaccgaacaa cctaaaaaag cgacagaaaa aaagccgagc cttataaaaa aatacggtat
      421 tgagtggctt ttgaacctga taaaaaaagt ggcagagctt gcagtatctg cattgcagga
      481 ttttttcagc cacatactgg ttaaaaaatt gtcgctgagt atcagcgttg caggtgacga
      541 tgcggctgac acggctataa aatacggcaa atactgtgcc gttgtttatc cggcagtagg
      601 cacaattgtc cgtgttgtaa aatgcaaagg ctacggagtt gacataaatc cgaatttttc
      661 ggaaaaagca gaaacagaaa ttaactttga ctttgccgca agaattttcg cattccgact
      721 tatcggtctt gccgttaagc acggaatcaa gggaattaaa cttcttgcag aagttaaaaa
      781 tgattgatat aaatattgtt gaaaaaggag aatggctatg gaacatccta tcggcagttt
      841 aatggatacc acaatggaaa aaatcaagga aatgattgat gtcaatacga ttatcggcga
      901 gcctataact tcgcctgacg gcacacttat cattcctgtt tcaaaggtaa gctacggctt
      961 tgcggcaggc ggttcggatc tgcctaccaa aaaggaaaac aaagactgct ttggcggagg
     1021 cagcggtgca ggcgtgacaa ttcagcctgt tgcatttctt accgtttatc agggcgatgt
     1081 aaggcttgtt tccgttgaca gggaagaagg tacagccgac aagctcgtta atatgattcc
     1141 cgatgttctc aaaaaagtaa agggagtttt caaaaaggat aagagcgaat ccgcagacga
     1201 tttttccgaa atcacacagg acgatattga cggctgattc gtaatattgc aacacccctc
     1261 ggcatagatt tatgcagggg gtgtccttat gaaaaaaata atcttgcttg cggtgtgctt
     1321 tgttatgccg tttgtgctta tgggcgcaaa aactgcggag gatactcctc ccacaacttc
     1381 tgcacaggca tttgttcttt attgtcccga taacaacacg gttatctgtt ccaaaaatgc
     1441 agatgaaaaa atgaagcctg cgagtaccac aaagattatg acctcgctca taacgcttga
     1501 ggaggcggca tcctgtaaca gcgaagtaac cttcaaacag aaaatggttg ccgagggcag
     1561 ttcgatgtat cttaaagtcg gtgaaaaagt tcgattttca gaccttgcgt caggaatgat
     1621 gatggcgtct ggtaatgatg cggcgaatgc ggcggcatat acgatttcgg gcagtcccga
     1681 aaagttttca caacgaatga atgaaaaggc aaagcaaatc ggtatgacga atactaattt
     1741 tgtaacgccg agcggacttg acgatgacaa ccattactca agtgcaaagg atatggctct
     1801 gcttatgtca tatgcacttg aaaatgacga ttttgcaaat cttacggcta agaagagcgt
     1861 gaccgttgaa tttcttgaac cgaaatcaaa gaaaaccgca tatgcaaatc ataacaggct
     1921 tttgtcgctt tatccctact gtacaggcgg aaaaacaggc tatacaacgg cggcagggcg
     1981 gtgccttgtt tcctctgcaa aaaaagacgg tgtaacgctt gtgtgcgtca ctctgaatga
     2041 ccgcaacgat tggaatgacc atatttctct ttatgattac gcttttgaaa agtacagggg
     2101 agttgactgc aaggacgctg acttttgtgc cgatattccg tgcgtgggcg gtgataagga
     2161 cagcgtaacg gttacagggg agaagaacaa cacaatcgtt ttaaagcgtg aggactgcga
     2221 taaaatcaag aaaaaaatct tcatagacag ctttttgtat gctccgattg aaaagaacga
     2281 atcggtcggc agaattgaat acacactcgg cggaaagctg ctttataaat gcaacattgt
     2341 tgcaggcgaa aagattaaat cggataaaaa gagtgtgtca atattttcgg caataggaaa
     2401 tctgttttcg tgacagctta aatatacaga aaattttaat aaaaaggaat ttacatatgg
     2461 ctaaaattga acctataaga cttcagaaat tcatagcgca atgcggtatt gcgtcaaggc
     2521 gaaaggccga ggagcttatt ctcggcggtc atgtcaaggt gaacggcaaa accgcaattc
     2581 tcggcgataa ggttcttcct acagacaagg tgtttgtaag aggcaagagg attgttgtgc
     2641 cgaagggcgg taattaccga tatattatgc tcaacaagcc ccgtggattc attaccacaa
     2701 tgaatgatga gcgtggcaga aagtgtgttg cgcagcttgt tgagaatgtc ggtgagcgag
     2761 tttatccgat aggcagactt gacaaagaca gcgagggtat gcttgttttt acaaatgacg
     2821 gtgactttgc aaacaaggtt atgcacccga aaaacaatgt ttacaagatt tacagagtaa
     2881 ccgttcgacc gtcaattgac gaggatcagc ttgtaaagct tgaaacaggc gttgagcttg
     2941 acggcaggaa aaccgctcct gcatatgtcc atgtaattca caaggagcag ggcagagtag
     3001 ttcttgaaat gatccttcac gagggtaaga accgtgaaat cagaagaatg tgcgaggctg
     3061 tcgggcttga ggttgcaaga ctcaaacgca cccagattgg cggagtaaaa atgggtatgc
     3121 tcaaacaggg cgactggaga gatttgaccg aacaagaggt taaaaaactg cttgcaaacc
     3181 cgtttttgaa cggcaaacag ctttaatttt ccgtttttga aaaatacttc caaaacggtc
     3241 aataaaacta ttcgttaatt cgacaataaa tttacggttt tggtgtaata actattaaat
     3301 gtgttcaaaa ttgaaatagt acagcgtgtt tttcttgtac ttttgaagat tatagagtat
     3361 aatgtatggt gtagaaaatt agtatgcacg ctcagttttc gtgcatattc aatacatggt
     3421 attggaggat tttaagatga gtattgaaaa gatcaatcag gcaaaggctg aaattgccgc
     3481 aacttccgct tataagacaa ttacggcgtt ttttgatgca gacagctttt gtgaaattga
     3541 tgcctttgca aaatccggag aaggttttgc cgaggttgtt gcaggctttg gaacagtaga
     3601 aggtatgcct gtttatgcgt ttgcacagaa cagcgacatt tgcggcggtg ctatgagtaa
     3661 ggcacaggct gccaagctta aaaagctgta tggtcttgca ctcaagacag gcgctcctgt
     3721 tgtaggtttc tatgacagcg ttggcggcag acttaatcag ggtacagagc ttctcgcagg
     3781 ttgcggtgat gttctcaatg cggctgcgtc actttccggt gttgtaccgc agatctcggt
     3841 tgttctcggc acttgcctcg gaacaaacgc tcttaacgcc gcaagcgcag acgtcgttat
     3901 catgagcaaa gacgcacagc tttcactttc ggtaacaggc aagcattccg atgccgctta
     3961 caatgctgaa aacggtattg catcaatcgt ttgtgacgat gcagacaagg caatcaaggc
     4021 tgcaaaggaa cttatccttt atcttccgtc aaataacctc acaatggctc ctcagtcatt
     4081 tgaagaagct ccggcagagg acggttgcgg ttgtgtagtc agcagaacag ttgacggcaa
     4141 cagcattgta aagctcttca atgattatgg caaggaagca aatgttcgtt ttgcaagact
     4201 cggcggtcag gttgtaggta ttgttgttac aaagggcaat gagcttggtt gcaagtctgc
     4261 aaacaaggta gcaaagtttg ttcgtttctg cgacgctttc tcgctccctg ttgtaacatt
     4321 cgtaaactgc ccgggctttg agtcaatcaa gtcggcaaca aaggcatcag ccgcttatgc
     4381 tgaggcaaca acagttaaga tttctgttgt tacaggcaag gcaatcggtt caggctatgt
     4441 tgctcttgca ggcacaggcg ctaatgcaga tgttgtttac gcacttcccg atgcggttat
     4501 ttcacctgtt aatgttgagg ctgccgcatt cattatggct cccgaagtta tgaatgttgc
     4561 cacagataaa caggctgagg ttgctcagaa gtttgctgac gagaatcttt ctgcttacaa
     4621 tgccgctcag aacggctatg ttgacggtat tgttgaagaa gctcagctcc gtcagactct
     4681 tatttctgca cttgatatgc tctcgggcaa gcgtgtttca acactttcaa agaagcattc
     4741 aactatctga taaatgatta cttgttaaaa taaaagggga tactaaaaat gaagaattta
     4801 agaattacag ttaacggcac agcatatgat gttcaggttg aagaactcgg tggctcttca
     4861 gctcccgcag cagccgctcc tgctccggca gccgctcccg ctcctgcagc aaagccggca
     4921 gctcccgcag gcgctcaggg ttctgttgtt gtaaaggctc ctatgcccgg tacagttgtt
     4981 aatgttgttg tttcggcagg acaggctgtt aaggccggag atgacctcgt attcatcgag
     5041 gctatgaaga tggaaactcc cgttaaggct ccgcaggacg gcacagttgc aacagtcgat
     5101 gttgcaaagg gtgagtcagt tgactcaggt aaggttctcg taacacttaa ctaatcaata
     5161 attcggagaa agggatgctg taaaatggca aaaaaaatca gagttaccga aactgctctg
     5221 cgtgacgctc atcagtcact cattgcaaca agaatgacaa cagaggaaat gctccctgtt
     5281 cttgacaaac tcgataaaat cggttattac tcactcgaat gctggggcgg cgcaacatat
     5341 gactcatgcc tcagattctt aaacgaagat ccgtgggaca gactccgcac aatcagagag
     5401 cattgcccta acacaaagct ccagatgctt ttcagaggac agaatatgct cggttatcgt
     5461 cactatgccg atgactgcgt tgagtacctt gttcagcgtt caatcgcaaa cggtattgac
     5521 attatccgta tttttgatgc tcttaacgac atcaagaatc ttaaaacagc tatcaaggcc
     5581 gctaacaaag aaggcggtca tgcacaggtt gctatcagct acacaacagg tcccgtattc
     5641 acagatgaat actatgttga gtatgctaag agaattgcag acgcaggtgc agattcaatc
     5701 tgtatcaagg atatggctgc tcttcttact ccgacaagaa ccgaaagcct tgtaaaggct
     5761 atcaaagccg ctgttccgga gcttccgctt cagctccaca cccactacac atcaggtctt
     5821 gcatcaatgt gtcttttgaa gggtgttgag gcaggtgccg acggcattga cacagcaatc
     5881 agcccactcg ctctcggtac atcacacgca cctacagagt caatggttgc cgctctttca
     5941 ggcacagagt tcgacacagg tcttgacctt aaacagttct ctgacatccg tgcttacttt
     6001 atgactctcc gtgagaagta catcaagtca ggacttcttg atcctaagat gctcgcaaca
     6061 gacgctaacg ctcttatcta tcaggttccc ggcggtatgc tttccaacct tctttcacag
     6121 ctcaagcagg ccggtaagga agacaagctt gacgaagttc ttgcagaagt accccgtgtt
     6181 cgtaaggatt caggttatcc tccgcttgtt actccgacat cacagattgt cggcacacag
     6241 gctgtattca atgtaatcac aggcaagcgc tactcaatgt gcacaaacga gttcaaggga
     6301 cttgttgccg gtgagtacgg tacaactcca atgccgattg atcctgcgtt tcagaagaag
     6361 attatcggtg acaagaagat tatcaaaggt cgtcctgcag atcagcttaa gcctgagctt
     6421 gataagctcc gtggcgagat tgagcagtgg attgaacagc ctgaggatgt tctttcttat
     6481 gcacagttcc cgaaggttgc cctcgacttc tttgaaaaga gaagaaatgc caaggttggc
     6541 atcaacggcg acaagcttga caagaaaaat atggttcacc cagtttgatt tgacaacaaa
     6601 aattaacatt tatgccactt tcgctatgaa agtggcattt tcatttgagc agaattattt
     6661 tatgtgaatt tttagcaact atattgcatt acatatattt tagcagtata atgaagtaaa
     6721 ttgaatatct gttgcgtata ccattattac agatagaata aataaaaggt gaggaaataa
     6781 gaatgaaaaa attattaact gcattgatag catttgtaat gtgcttttcg gttgtaacaa
     6841 cagcttttgc ggctacacct gatgaaactt ctgattcaga cttgatttca gatattaaac
     6901 aggctatgtt agatacatat tatggtgatg aaaagcctga atatctgaat gtcgaaattc
     6961 ttttggacga tgaagacgag gtatatttca gtttttctga cagctttgct acttctgcaa
     7021 acagagttta caccgaggca ggcaattaca tagtttctta tctcgaaaat tgtcctgtgg
     7081 cactgtacaa aaacaacagg gtttatatga tccccgatgc ttataattcg ggcattattg
     7141 atgacgatac acttgagggc ttgacctatt gcggacatat ggatatagtt ccgaaaagcg
     7201 atgattcagc acttgttatc gaaataaaaa acaaagttat tgaagagtgt tttgacggca
     7261 aatcacctga aactttgaga attgatattg ttggcagaac aagtgacggc ggagtgtgtt
     7321 ttagatatag ttttggcggt ggtatggatg taattgttga agaaacaatt ggtgactata
     7381 cttatagtta caaccatggc gatgatgtta tgctttataa aaatggcaat gtttactcaa
     7441 tcaaagaggc ttatgaaagc ggagttattg acgatagtat tcttgaagaa ttgtcaaaaa
     7501 tgaattttgg tttgaaatct aataaaccga atacaactgt ttctactgag cctacaacta
     7561 cggttgcaac agttgacgaa cctgtaacag tacccgatac aacttctgca acttcggcaa
     7621 ctaagcctgt ttcaacaagc gacacagcta caaaggacac accgaacaat tcacagaata
     7681 acagcggtgc tgtacagaca ggacagaaca gcgttgcggt aattcttctt gttgcaatgc
     7741 ttgcaggttg tgcagtaatt tttgcaaaac gcagaaatca ttttgagtaa tttacaaatt
     7801 aaataatccc tataaaagcc gttctcgtta ttgagagcgg tttatttatt ttagcttaaa
     7861 aaatttgtga tagtttatca agatgtattg ctttttatat catttaatgt tacaattaac
     7921 ttgcataaaa atttagcgaa agtccttaat aatgcgtaga atttgaacaa agtgagggat
     7981 atatatgaaa aagtttttac ctatagccat ggcggcggta atgtcgatgt ctgcgattgc
     8041 ggtttcggca gtttctgcaa atgcggttga accgctaaac acacccgtgc agtatgcaca
     8101 ggttgcaagg gcaagcttgg caactccgaa aatttcaaaa gccgaaagtg tttacggcgg
     8161 tgtaaagctt acatggaaca aagtgaacgg tgcggctaaa tacagagttt actacaaggg
     8221 ccgtaaaggc tggacacgaa tggtcgatac aacttcaaca tcatatatcg acaaggatgt
     8281 ttcatcgggc aggaattaca cctatactgt aagatgtatt tctgctgacg gaaagagctt
     8341 tacaagcggt tatgattcaa aggggacaag cgtaaaatat gttgctgctc ccgaaatttc
     8401 aaagcttgaa aatgtaaacg gcggtgtgaa aatctcttgg ggcaaagtaa gcggtgcgac
     8461 taaatacaga gtttactaca agggcagtaa aggctggaca aaaatggttg atacaacttc
     8521 aacctcatat atcgacaagg atgtttcatc cggcagaaat tacacttata cggttagatg
     8581 tattacatca gacgcaaaga aatttacaag cggttataac ccaacaggca agtcggtaaa
     8641 gtatgttgcc acaccgaaaa tttcaaaact tgaggtcaca tatgacggcg taaagctgac
     8701 atggaacaag gttgcaggtg cagagaagta tcgtgtgtac tacaaggaca gaaacggttg
     8761 gacaaagctt gccgatacaa caggcacgac tatgcttgat atgaatgttg tttcaaagga
     8821 atttgattta agcattgatg atatttatta cacggttcgt tgtatcagca atgatgccaa
     8881 gagttttaca agcggctacg attcaaaggg tacgcccatt ggcgatcatc aggattgtcc
     8941 cgaaatttac agcattggtg cagtaaacaa cggtgttgaa atgcattgga cgggagatgc
     9001 gccaaagttc cgtgtttata ttaaagaaaa cggttcttgg aagaggatag cagaaactta
     9061 tgacaactat tatgttcaca agggtgcaaa gtccggcagt aacacttata cggtaagagg
     9121 tgtttcaaaa gacggtaaaa agtttactac gatgtttaac ccaaccggtg taacatacag
     9181 atataagaca tccgataaaa caagggatgc ttatatcaat tatatgatga atcatcagag
     9241 tgaatggatg ccaagcttgg gaagtaatca caatttgtca ggtgttatgt ttttggattt
     9301 cgactttgac ggagttccgg agcttgttgc acaaaaggct gattccaatg agtatagttt
     9361 ccattccgtt gtttacaaat ttgaagacgg taagttaaaa agagtgggaa atgttaacga
     9421 cggttttgcg atatactata ataaaactgc caaaaagtat gaggttcacg acctaaagat
     9481 atctttaaat gtagatgacg gttactattg gtcgggtaat tcaataatca catacgacgg
     9541 agagaatctt tttgcaaata tgtattcggc aagaggtgta ggcgaagaat caaataataa
     9601 tatttattat aattattttg acggtaatga caaaaatatt tcacgggcaa aatataacga
     9661 aattaacctt aaacagttta ataattgcgt aaatgcacat atgtttaccc aatttattgc
     9721 gacaggttat ggtgatgcca gcgtatgggg tgagaacact accgctgaga ataagcagtc
     9781 tttgcttgac gcatataatt ctttctccta tgagaagtat tgattattta aaaattgata
     9841 agttttaact gcaaaagggt tcagccgtaa aaagctgaac ccttttattg cacaacaaaa
     9901 aacggttcag ccaaattgac tgaaccgtta atctgtacta tgttaagctc gggtgacaga
     9961 agtttgaata tatcaaacta acttcacgaa ctaaaaaaca ttagttgttg atgagcttat
    10021 cttcgtcaga ccagctgtag agctttctaa cttccttacc gaatacttcg gcaggagctt
    10081 cggcagcgag ctttctcata gccttgaagt gaacctgtga accggcatcg ctcatgtcaa
    10141 ggaggaagtc cttagcaaat gtaccgtcct gaatgtcaga aagaaccttt ctcatagcct
    10201 tcttagtatc ctctgtgatg atctttggac ctgtgatgta gtcaccgtac tcagctgtgt
    10261 tagagattga atatctcatg cctgcaaaac ctgactgata gataaggtca acgatgagct
    10321 tcatctcatg gatacactca aagtaagcgt ttcttgggtc gtaaccggca tcgcaaagtg
    10381 tttcaaaacc tgcctgcata agtgcgcaaa caccgccgca aagaacagcc tgctcaccga
    10441 agaggtctgt ttctgtttct gttctgaatg ttgtttcaag aacgcctgct cttgcaccgc
    10501 cgataccgag tgcatatgca agtgcgagat ccttagcctg acctgtagca tcctgctcaa
    10561 cagcaacgag gcaaggtaca cccttaccaa cctgatactc tgaacgaact gtgtgacccg
    10621 gtcccttagg agctaccatt gtaacatcaa catcctttgg aggcttgatg caaccgaagt
    10681 gaatgttaaa gccgtgagcg aacataagca tattgcctgc ttcgaggttt ggctcgatgt
    10741 cgttcttgta aagagctgcc tgcttttcat cgttgataag aatcatgatg atgtcagcct
    10801 gctttgcagc ctctgctgat gtatatacct taaagccctg tgcctcagcc tttgcccagc
    10861 tcttgctgcc tttgtaaaga ccgatgatta catcgcaacc tgaatccttg aggttgagag
    10921 cgtgtgcatg accctggctg ccgtaaccga taatagcaat tttcttaccc ttgagaaggt
    10981 caaggttaca atctgactga tagtagattg gtgctgtcat gttttttgtg tagtctttca
    11041 tattaaagtc ctccttaccg caaacgcggc atataaatta aaatatatgc taactgtaag
    11101 attaaacgga aaccgaagct gtgcctctgt caatggcaac agtacctgtt cttacaatct
    11161 cacggatacc ataaggcttg agtaagtcaa caagcgtgtt gatgcggctt gcacattcgc
    11221 agtactcaac ggtaactgac gaaggggata catcaacgat ttttgcctgc ataatttcaa
    11281 ccgttttgac aatttcggct ctttttgagg cggcacagtg aaccttgatt aaaacaagct
    11341 cacggctgat aaattcgccc tcgttaagcc tttttacctt aataacggga atgagcttgt
    11401 tgagctgttt ttcaagctgt tcaacaatgt actcgtcacc gtttgcaacg attgtgattc
    11461 gggaaaccga cgggtcctga gtaacaccta ctgcgagtga gtcgatgtta aaacctcggc
    11521 gagagaaaag tcccgaaatt tttgaaagaa cgcccgcctg attttcaaca agtattgata
    11581 atgtatactg cattttatca cctcattaaa ttgacggagt gtcggggtga acatcgcaaa
    11641 caagaatgaa cggtttttcc gaatcaacaa tacccttgat gatgttttcg gcttccttgt
    11701 ttgaatgagc ctctgcatgg tcaatgccgt aagcatcggc aatcttcaag aagtcgggat
    11761 caccgttgag aattgttgca gagtgtctgc cgccgtagtg tttgtcctga agttcacgaa
    11821 ccattccgag tcgtgcgttt ttcataatga tgattttaat tccgagctga ttgcctgcaa
    11881 tagtcgcaag ctcattaagc cccatctgaa aactgccgtc accgcagatt acaataacat
    11941 cacggtctgg tcttgcaaac tttgcaccga ttgcagcggg aattgagtaa cccattgtac
    12001 ccataccgcc tgttgtgagg aatctgccct cacgaatacg gaagttgttt gcacaccaga
    12061 tttgattttg tcctacgtcg gcaacaagaa ttgcctttga gcggaacatt gcactgagat
    12121 gaccgacaag tgttctcggc tcaacaaagc cgtcaaaaac gggaggctca cggtaaaggt
    12181 cttttttcca gttctttacg gtttcgctcc acattgttgt aaccttgtaa tcgccgatgc
    12241 tgtcaagcag catattgatg acatttttca tatcgcctac aatcggaatt tctgttttaa
    12301 cattcttacc gatttcagca gggtcaatgt caatgtgaat tacctttgtg ttttcactca
    12361 tctggtcggg agccgcaaca gctctgtcac cgagtcttgc accgcatacg attacaaggt
    12421 cggcttcgtg aagagcacgg ttggcaacag ccttgccgtg agtgccgagc attccgagat
    12481 aaagctcatg ctcgctgggc ataacaccga tgcccatcat agttgaaata acggggatac
    12541 ccgtagtttc tgcaaatttt tgaagtttaa gcttgatacc cgaacttagt acgccgccgc
    12601 ctgatacgat aacaggacgc ttgcttgcgt tgatggcctc aacagccttt ttaacctgaa
    12661 ttgcgtgtcc cttagtgttc ggcttgtaac cgatgatgtt tacgctttcg ggatattcaa
    12721 aactttcaat ttcattttcc tgaatatcaa cgggaatgtc gataagtaca ggaccgggtc
    12781 tgccggttga ggcaatatgg aaagcctctt tgaaaactct cggaaggtct tctgttttgc
    12841 tgacgagata actgtgcttt acaaacggtt cacaagctcc cgtgatgtca gcttcctgaa
    12901 agacatctct gccgagaagg tcggaacgaa cctgacctgt aatggcaaca atcggaatag
    12961 agtccgtata ggcggtcgca atacctgtga tgaggttggt tgcaccggga ccggaagttg
    13021 ccacgcaaac accgggacga ttactgcatc ttgcatagcc gcttgccgca tgagcagcgt
    13081 tctgttcctg acgaacaaga atgtgggtaa tgctcgaatc gtaaacttta tcgtaaaatg
    13141 ggcaaatagc cgcaccggga taaccaaaga ctatgtcaac gccctcggct tccaaacatt
    13201 ttaccataat ttcagcaccg ctgatcatta tgttttgtcc ctcctatcct ttttactgtg
    13261 agcaaaaggt gttttgtaac attaaatata cctttttact ttaccgctaa ttatacaata
    13321 aataccttaa aaagtaaaga gcagtattgc ccataaatta aattttttgc aggattttga
    13381 cagataattt gcaaaatgaa ttttaattgt tttttactcc ctgcttactg aaattttaag
    13441 tcgcttagtt ttgtaaagta tattcttgga ttaaggtcac tttttttgtc tgcattatca
    13501 ggggacatca ttatcatcaa attatctttt cctatccgtg atataccgcc tatagtgtac
    13561 cctttttctt caatattaaa ttttgtttct ttcattgttt tgttggtcgt atcaaaaaga
    13621 tatatgtagt tattttctga acttgattcc gccctcttat acaataaatt tgtatcactg
    13681 tcatcttcag atgcggatac tattgaaaaa gtatcatcta catcttctga tatgtcggat
    13741 tttttcagct tatcgctgtc tatatatcct atacatcttg ttatgctgaa attttgatag
    13801 aatagataat tgtttttaaa atcaaaaacc tgtacgccct gaattaattc gtttgaatca
    13861 tctgaaatgt tagaaatatc atagcttttt tgaaaattca tatcatagtc ataagtttct
    13921 atttttaaag aagcttcgtt ctgtgaaatg caatccaaaa ccaaaagaga gattgttttt
    13981 gtacttttgt caattgaaac ttttcttata gtttccccga tactgttttt atcatcaaac
    14041 tctaaatatt ttaattgctt gaatttttga gtttcggtat catacagttc caaagaagta
    14101 ccgttgtcta gcacttttgt gattatgaca agattgtctg ctcctgtaac agtgtcatat
    14161 ggaaatccgc ctttgtcaga aaatacagtc gtcattttgt ttttattaag gtcgatatca
    14221 ataaattcaa gagttctgtt ttcttcgtct gtaatgtcgc ccgtgcttgc cgtaaagcaa
    14281 aggtgattat ttacataagc tttatcgtga atttgcatat accagttttt tattgaacca
    14341 agttttacac tgtttttttt atctaaataa tatctgtagt attccatttc atttggagag
    14401 tctttattga tttttgaata tatgaagccg ttatcaattt gtttaaataa gccgtaaaga
    14461 tttaaagtat ccaccttttt gccgttattg taaatttcta agttatgatt taattctgtt
    14521 gtttcaatat ctgaatcaag agataaatca tctgtatccg ttacggttgt ttgttcagtg
    14581 gggttattgc ttgatgaaga agtgttacat ccatataatg aaagtaaaaa taaagcggtt
    14641 actaataata aaaatatctt tttcaaatta atctctccga agtttattta
//
