LOCUS       c00047_gnlPro..        12172 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DDDCDFAK_47.
ACCESSION   c00047_gnlPro..
VERSION     c00047_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 22:47:43
            Original ID  :: gnl|Prokka|DDDCDFAK_47
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12172
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12172
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4745:8992]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4746..8992
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..12172
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12172
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             146..667
                     /locus_tag="ctg47_1"
                     /transl_table=11
                     /translation="MGEKYYWVIGFCCGFIAVVIVTLIIANIKRKKNTYTEYDERQVLA
                     RGKAYKSAFFVLIGYIIACALVNVLEINWAELSVQMFIGLFLSTAVFVGISIFNDAYFT
                     SNKGRKSLLGVLAFIAGAEYLGIAFGNKTFVTNGIANLDIIPIIVMIWAISIFVMVVIK
                     TIIDKKAVEE"
     CDS             664..858
                     /locus_tag="ctg47_2"
                     /transl_table=11
                     /translation="MKNLRLKSARAAKDLSQQQLAELVKVSRQTISAIEKGDYNPTINL
                     CIAICKALDKTLDELFWEE"
     CDS             1072..1764
                     /locus_tag="ctg47_3"
                     /transl_table=11
                     /translation="MIYSKEVENMCTVAKGPKHGPAPIPEEGKWVKSYDIKDISGLSHG
                     IGWCAPQQGACKLTLNVKDGIVEEALVETIGCSGMTHSAAMAAEILPNKTLLECLNTDL
                     VCDAINTAMKNIFEQLVYGRSQTAFSEGGLPIGAGMEDLGKGLRSQVGTMYSTNAKGVR
                     YMEMAEGYVLKTALDENDEVIGYQFVKLGKMLEDIRHGVEPNEAYKNNIGQYGRFDGAA
                     KYIDPREE"
     CDS             1786..2790
                     /locus_tag="ctg47_4"
                     /transl_table=11
                     /translation="MAVTFEGMERRMPKIEKCLAEYGIANLEEARKICNDLGFDPYDIV
                     KGVQPIAFENAGWAYTLGCAVAVKKGAKTASEAAEAIGIGLEAFCIPGSVAEQRNVGRG
                     HGNLGAMLLRDETKCFAFLAGHESFAAAEGAIGIARNANKARKEPLRVILNGLGKDAAY
                     IISRINGFTYVKTQFDYFTSELKIVEERAFSDGERAAVRCYGADDVREGVAIMQHENVG
                     VSITGNSTNPTRFQHLVAGTYKKWANENGVKYFSVASGGGTGRTLHPDNMGAGPASYGL
                     TDSMGRMHGDAQFAGSSSVPAHVEMMGLIGMGNNPMVGATVACAVAVYEAVNK"
     CDS             complement(2964..3662)
                     /locus_tag="ctg47_5"
                     /transl_table=11
                     /translation="MPEKKITKAIVCPMCGEMSKADVYTSINPSVTKGVRRRALDGELF
                     AWKCPSCGYSARLTYPILYNDMKNRFMVYFIPKIDHFQLCDNELEEKYSNLRNISKRIV
                     PTFNSFKEKIFIFESGLDDMSVELTKLAISQTVSKKLNGAEIHDGYLSMYDRERNTMGF
                     TYFTGEKHTPYVQTARLEIYVKSKKIVDSLAYKDKKLKGFLKIDREWAENILYRYKRMK
                     HIEKLNKLKE"
     CDS             3807..4460
                     /locus_tag="ctg47_6"
                     /transl_table=11
                     /translation="MCQSVCAKAVLKEKFTMTILDSVKGTVNTAVDTISSVAQTIVEKN
                     RTNAKLNRLRLVMKSESELMNRAYIALGKVMYDSRKKGTEINDAECEKLLKVIDTSKAK
                     IAKARECYRKIVNSSNDIFYGNPEVAPEVKEDDIVDITVACSNEGDYKSSPFKEEKPVE
                     KQPEAVTEEKAEPEHLTNICDLKAELEAKREEGFSESADSDEADDGEAPHGELF"
     CDS             4746..7649
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_7"
                     /sec_met_domain="HGD-D (E-value: 4e-18, bitscore: 55.6,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 4.3e-39, bitscore:
                     123.9, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKLGLDIGSTTIKCVVLDDENKLIYSTYERHYSRITEKIAEILAL
                     VRTRIDGVENASVALSGSAGMGVAESVGVDFIQEVYATRVAANTFIPGTDVIIELGGED
                     AKILFLTNGLEVRMNGTCAGGTGAFIDQMATLLNVKLEDMDELAKQHEKTYTIASRCGV
                     FAKTDIQPLLNQGARKSDIAESIFNAVVSQTVAGLAQGREIEGQIVYLGGPLTFMSELR
                     NCFDRTLGTKGICPENSLYYVACGAALCAEKTIDFDEVIEKVKNYRGSGNFAFNQPLFK
                     NEEEYREFCDRHAKADVKQKELKGYTGKAYIGMDAGSTTVKGVVLNDDGELLYSKYLPS
                     KGNPVEIMKQFLDEVYEINPEINVVSSAVTGYGEDIVKNAFAVDYGIVETIAHFTAAKY
                     FMPDVEFIIDIGGQDIKCFKIHNGAIDNIFLNEACSSGCGSFLQTFANALGYEIADFAK
                     LGLFAKRPVDLGSRCTVFMNSSVKQAQKDGATIEDISAGLSLSVVKNALYKVIRASSPD
                     ELGKRVVVQGGTFLNDAVLRAFEQEMGVEVVRPNIAGLMGAYGAALYAKKKSKGVGKST
                     ITDKKGLDEFVHEIKVANCGMCNNNCRLTINSFGKGRKFVAGNRCERPITKKAPANDMN
                     MYAYKLNLIDSYKPVEGIRGKLGIPMALNMYELYPFWYRFFTELKFEVFHSPYSTRKLY
                     QRGQQTIPSDTVCFPAKLVHGHIQTLIDMGAETIFYPCLSYNFDEHLGDNHYNCPVVAY
                     YPEVIKNNMKDIRKVHFIKEYFGIHRPNDFPKKAYERLSFHFPDLTLNEVRNAAKLAYQ
                     EQENYRKKVIDKGSEIIAKAEKEGKKIFVLAGRPYHIDPEINHGIDRLISGFDVAIVSE
                     DVISPRVEHFRTHVLNQWTYHARLYAAAKYVTTRKDMELVQLVSFGCGVDAITTDEVRE
                     ILESKNKIYTQIKIDEITNLGAVKIRIRSLLAALEND"
     CDS             7649..8992
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_8"
                     /sec_met_domain="HGD-D (E-value: 1e-27, bitscore: 87.1,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGNSVMAELKYDKKTGRLLFTKQMKKEYTILMPNMAPIHFKILE
                     KVFNYYGYKSDLLDTTGPEIAQTGLKYVHNDTCYPALLVIGQFINALQSGKYDVHKVAL
                     MITQTGGGCRASNYIFLLRKALKKAGFEFVPVISLSFGMEHNSGFSLTLPLIRRFVGGL
                     VYGDQLMLLSNQTKPYEVNKGESMALVDEWTDKISDMLIQGKGYTLEEIDETLDRITKS
                     FTKIELNKVPKVKVGIVGEIYVKYSKMANNGLEDFLADQDCEVCVPGLMGFASFKVDNR
                     IEDYKMFGGSRVKYKFCSMLLNYLTKLEGLMVDAAEKYGFVPPHRYAHTKELVNGVIGY
                     GSKMGEGWLLTAEMIELADTGYENIVCTQPFGCLPNHINGKGAIRKIKEIRPNANIVTI
                     DYDPGAPKVNQENRIKLMLAVGKEELKKKLEAEKNGEKAESSEKSEKK"
     CDS             9195..9932
                     /locus_tag="ctg47_9"
                     /transl_table=11
                     /translation="MRQHKVKAGVYIIIRLILVSLLTAGILNGKWENVMTCVLTLGLLM
                     LPLFIDRKLSVALPSVLETIVVLFVFAANVMGELGAFYEKIPIWDSLLHTVNGFICAGV
                     GFGLTDILNRSERVKLSLSPMFVCLFSFCFSMTVGVVWEFFEFGADMLFEKDMQKDTVI
                     TAIHSGLISGKPNVIMHIRDITSTVVNGENLGINGYLDIGLIDTMKDLLVNFVGAVVFD
                     TIGWFYLKGRSAGFLRNFIPVKK"
     CDS             complement(10137..11876)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trypsin_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1057:Trypsin-like peptidase (Score: 122.8; E-value:
                     7.2e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg47_10"
                     /sec_met_domain="Trypsin_2 (E-value: 1.2e-38, bitscore:
                     122.8, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNFDNNNMGGFEPQKPFTEKPVQNNNMNTEQTIPVSEPETQEEQ
                     AQNVQPQNGNTPYGDYIFGNNNQNTANNANPTENVPPYQQNQNPNPNTYAQPWQYGYGQ
                     YPYSGQNPQYNQNNQQYGQYQNNTGYNQNVPPYQQNMYGQPPYGNNGTYNQQYNPQMFA
                     QYPQKKTKGGIIALIIVLCSLLTIGFIGMMVYGFSADIKEDLNNDRSDSGNSFRLPNKD
                     STTPFETLPNTSSQGKTHDESDYSDKVNKDYSGMKLESNPKDAKTNNSYTAAKASEKVS
                     DSVVGILCYSDDVPDQADTTTASSQGSGIIFSQDGYVITNAHVIGNSKTAYAIRVVTSD
                     GKEYKAGVVGYDSRTDIAVLKMDDAKGLTPATFGDSSQLEVGQDIIVVGNPGGLDYQNT
                     TTKGVISALDRKLSTSSLTKYIQTDAAINPGNSGGPLVNYYGQVVGITTSKIVSETYEG
                     MGFAIPSQTVKSIVDTLVKNGYVEGRVKIGISGIAVTSDQASNYNIPQGIYVQSIVSGG
                     PCDGTSLEEGDIITEVDGETITSFADVYAILETHKPGDKIKVKYYSSSSGDGEVEITLQ
                     EDK"
ORIGIN
        1 ataatggtac agaaagcttt ttgtacgcat tgtggatttt ttaagtattc acatctaaac
       61 acataaaatt ttttaatatt atttgcggat tatcggttgt acgaataaat ctgcaaattg
      121 gctgatttat tttggagatg ttattatggg agaaaaatac tattgggtga ttggtttttg
      181 ttgcggtttt attgccgtag ttatcgtaac gctcattatt gcaaacatta aaaggaaaaa
      241 gaacacttac acagaatacg atgaacgaca ggttcttgca cggggcaagg cttataaatc
      301 ggcatttttt gtgcttatcg ggtacataat tgcctgcgct ttagttaatg ttttggagat
      361 taattgggct gaactcagcg ttcaaatgtt cataggactg tttctttcaa ctgccgtatt
      421 cgttgggata agcattttca atgacgcata ttttacatca aataaaggca gaaagagtct
      481 tttaggcgtt ttggcattta ttgcgggagc agaatatttg ggaattgctt tcggcaacaa
      541 aacctttgtt acaaacggaa tagcaaatct tgacattatt cctatcattg taatgatttg
      601 ggcaataagt atttttgtga tggttgtcat caaaacaata attgacaaaa aggcagttga
      661 agaatgaaga atttaagatt aaaaagcgcc cgtgccgcaa aggatttgtc acagcaacag
      721 cttgcggaac ttgtaaaggt gtcaagacag acaataagcg caattgaaaa gggcgactac
      781 aatcccacaa ttaacctttg catagcaata tgtaaagcgc ttgacaaaac ccttgacgaa
      841 ttgttttggg aagaataagt aaactttaac ggcaatcggt gatttgtttc acggttgccg
      901 tttttatttt taccgtttca aaatcaaacg gtaaattgct acgggaaata ttacaatgtg
      961 ggggaattgt aaaaattaac gaaaaatgct tgaaaaatgt cgggttaagc cgtataatat
     1021 aggtgtttga ggatttcgga ctcatacaat ttattgaaag gagaagtaca catgatttat
     1081 tcaaaagaag ttgaaaatat gtgcactgta gcaaagggac ctaagcacgg tcctgcacct
     1141 attcccgaag agggcaaatg ggtaaaatct tatgacatta aagacatttc aggtctttca
     1201 cacggcattg gctggtgtgc tcctcagcag ggtgcctgca agcttacact taatgttaaa
     1261 gacggtatcg ttgaagaggc tcttgttgaa acaatcggtt gttcgggtat gactcactct
     1321 gcagctatgg cagcagaaat tcttcctaac aaaacactcc ttgagtgtct taacacagac
     1381 ctcgtttgtg acgctatcaa cacagctatg aagaacatct tcgagcagct cgtttacggc
     1441 agaagccaga cagctttctc agagggcggt cttccgatcg gcgcaggtat ggaggatctc
     1501 ggtaagggtc ttcgcagcca ggttggtaca atgtacagca caaacgctaa gggcgttcgt
     1561 tacatggaaa tggctgaagg ctatgttctc aagacagcac ttgacgagaa cgatgaagtt
     1621 atcggctatc agttcgtaaa gctcggcaaa atgctcgagg acattcgtca cggcgttgag
     1681 ccaaacgaag catacaagaa caacatcggt cagtacggtc gttttgacgg cgcagctaag
     1741 tacattgacc ctcgtgaaga ataattcggt aaggaggaca ccataatggc agtaacattt
     1801 gaaggtatgg aaagaagaat gcctaaaatt gagaagtgcc ttgccgaata cggtattgca
     1861 aatcttgaag aggcaagaaa aatttgtaac gatctcggtt ttgaccccta cgacatcgta
     1921 aagggcgttc agccgatcgc atttgaaaac gcaggctggg cttacacact cggttgtgca
     1981 gttgcagtta agaagggcgc aaagactgct tcagaggcag cagaagctat cggtatcggt
     2041 cttgaggctt tctgtattcc cggctcagta gctgagcaga gaaatgttgg ccgtggtcac
     2101 ggtaacctcg gcgcaatgct cctcagagat gaaacaaagt gctttgcatt cctcgcaggt
     2161 cacgaaagct ttgcagcagc agagggtgct atcggtatcg ctcgtaacgc taacaaagca
     2221 agaaaagagc cgctccgtgt tatccttaac ggtcttggca aggacgctgc ttacattatt
     2281 tcaagaatca acggctttac atatgtaaag actcagtttg actatttcac atcagagctt
     2341 aaaatcgttg aagagagagc tttctcagac ggtgaaagag ctgcagttcg ctgctatggc
     2401 gctgacgatg ttcgtgaagg tgttgcaatc atgcagcatg aaaatgtagg tgtatctatc
     2461 acaggtaact ctactaaccc gactcgtttc cagcacctcg ttgcaggtac atacaagaag
     2521 tgggcaaatg agaacggcgt taagtatttc tcggttgcat caggcggcgg tacaggccgt
     2581 acacttcacc ccgataacat gggtgcaggt cctgcatcat acggtcttac agactcaatg
     2641 ggcagaatgc acggtgacgc tcagttcgca ggttcatctt ctgttcctgc tcatgttgaa
     2701 atgatgggcc ttatcggtat gggtaacaac ccgatggttg gtgctacagt tgcttgcgca
     2761 gttgcagttt atgaagctgt taacaagtaa ttaccaatct tttcaataaa ttaaaaaggg
     2821 gtcggctctt tgagtcgatc cctgattttt tttgtgcatt ttattttaac gagtttatgt
     2881 ttacggatat tctttacagt gtatatgtta cttgtttgca gatttttttt aaaccaaaag
     2941 aatcgactga ctacagtaac agcttactct ttcagcttgt taagcttttc aatatgcttc
     3001 atgcgcttgt agcggtagag aatgttttct gcccattcac ggtcaatttt aagaaagccc
     3061 tttaactttt tgtccttata tgcaagcgaa tcgacaattt tcttcgattt aacataaatt
     3121 tcaagtcttg ctgtctgaac atacggtgta tgcttttcac ctgtaaaata tgtaaatccc
     3181 attgtgttgc gttcacgatc gtacattgaa aggtatccgt catgaatttc cgcaccgtta
     3241 agcttttttg aaaccgtttg gctgattgca agctttgtaa gctcaaccga catatcgtca
     3301 agtcccgact caaagataaa aattttctcc ttgaacgaat tgaaggtcgg aacaattcgt
     3361 ttgcttatgt tgcggagatt gctgtatttt tcttcaagct cgttgtcgca gagctgaaaa
     3421 tgatcaattt tgggaatgaa atacaccata aaacgattct tcatatcatt gtagagaatc
     3481 ggatatgtga gccttgcgga gtatccgcat gacggacatt tccacgcaaa aagctcaccg
     3541 tcaagcgctc ttctgcgcac accctttgtt acggacgggt tgatgctggt gtaaacatca
     3601 gccttgctca tttcaccgca cattgggcag acgattgcct tggtaatttt cttttcaggc
     3661 atccaaacca cctctttaac actctatgaa actaattata gcaattgacc gtgattttaa
     3721 caagtaaatt ttaaaaaaat gttgatttta tcaaaaaaat ctgtcataat aatagaaata
     3781 agtttaatat tattcgccac ggcagaatgt gtcagagtgt ttgtgccaaa gcggttttaa
     3841 aggagaaatt tactatgacg atacttgaca gtgtaaaagg aacagtaaat acagccgttg
     3901 atacaatttc atcggtagct cagacaatag tagaaaagaa cagaacaaac gcaaagctca
     3961 acagattaag acttgttatg aaaagcgaaa gcgagcttat gaacagagca tatattgctc
     4021 tcggaaaggt tatgtacgac agcagaaaga aaggcactga aattaatgac gccgagtgcg
     4081 aaaagctttt gaaggttatt gacacttcaa aggccaaaat cgcaaaagca agagagtgtt
     4141 acagaaagat tgtcaacagc tcaaacgata ttttttacgg caatcccgag gttgctcccg
     4201 aggttaaaga ggatgatatt gttgatatta cagtagcttg ctcaaatgag ggcgactaca
     4261 agtcctctcc ttttaaagag gaaaagcctg ttgaaaaaca gcccgaggct gttaccgaag
     4321 aaaaggcaga acccgagcat cttacaaaca tctgcgacct caaggcagag cttgaggcaa
     4381 agcgtgaaga aggattctcc gagtccgcag attcagacga ggcagatgac ggtgaagctc
     4441 ctcacggtga acttttctga taatgtaaat acttaaagct aaagacctgc cgatttcggc
     4501 aggtttttct gcatttttaa gatatattaa agtcggaaca atgctccgct ttgcttttga
     4561 gggcaaatta tatgcagtag attatacatt atgcccttta tgtgtattga atttttgtga
     4621 taaaaatggt aaaattcatc aaaggtgaaa atattccaaa ttagaattat tttcttgaca
     4681 aaaaatacta taattaatta gatatgcaca atgagattac tatgtattga tttcggaggc
     4741 acaagttgaa attaggattg gatattggct caacaacaat aaaatgtgtt gtgcttgacg
     4801 acgaaaacaa attaatatac agcacatatg aaaggcatta ttcccgaatt acggaaaaga
     4861 ttgcagaaat tcttgcactt gtacggacaa ggattgacgg cgttgaaaat gcctcggtgg
     4921 ctctttcggg ttctgccgga atgggtgttg ccgagtctgt cggcgttgat tttattcagg
     4981 aggtttacgc aacaagagtt gccgccaata cttttattcc gggtacagac gttataattg
     5041 aactcggcgg tgaggatgca aagatattgt tcctcacaaa cggacttgag gtaagaatga
     5101 acggtacctg cgccggcggc acgggtgcgt ttattgacca gatggcaaca cttctgaatg
     5161 ttaagcttga ggatatggac gagcttgcaa aacagcacga aaagacatac acaatcgcat
     5221 caagatgcgg tgtgtttgca aagaccgata ttcagccgct ccttaatcag ggtgcgagga
     5281 agagcgacat cgcagagagt attttcaatg cggttgtaag ccagactgtt gcaggtcttg
     5341 cacagggcag agaaattgaa ggtcagattg tatatcttgg cggacctctt acatttatga
     5401 gcgaactgcg aaactgcttt gaccgcacgc tcggaacaaa gggcatctgc cccgaaaatt
     5461 cactttatta tgttgcctgc ggtgcggctt tgtgtgccga aaagactatt gattttgacg
     5521 aggttatcga aaaggtaaag aactaccgtg gaagcggtaa ctttgcgttc aatcagcccc
     5581 tctttaaaaa cgaagaggag tacagggaat tctgcgaccg tcatgcaaag gctgatgtta
     5641 agcagaagga gctaaaggga tacacaggca aggcttatat aggaatggac gcaggttcaa
     5701 caaccgtaaa gggcgttgtc ctcaatgatg acggcgagct gctctattca aaatatctgc
     5761 catcaaaggg aaaccccgtt gagattatga agcaattcct tgacgaggtt tacgaaataa
     5821 atcccgaaat aaatgttgtt tcttctgccg taacaggtta cggagaggac attgtaaaga
     5881 acgcatttgc ggttgattac ggcattgttg aaacaatcgc ccactttacc gccgcaaaat
     5941 actttatgcc cgatgttgaa tttatcatcg atatcggcgg acaggatatc aaatgcttta
     6001 agatacataa cggtgcaatt gacaatatat tccttaatga ggcttgttca tcgggttgcg
     6061 gaagcttttt gcagactttt gcaaacgctc tcggatatga gattgccgac tttgcaaagc
     6121 tcggactttt tgcaaagcgt cccgttgacc tcggctcacg ctgtaccgta tttatgaatt
     6181 caagcgttaa gcaggctcag aaagacggtg ctacaattga agatatctcg gcaggccttt
     6241 cactcagcgt tgtaaagaat gccctttaca aggttattcg tgcgtcaagc cccgacgaac
     6301 tcggcaagcg tgttgtagtt cagggcggta ctttccttaa cgacgctgtt ttgcgtgcat
     6361 ttgaacagga aatgggcgtt gaagttgtgc gtcctaacat tgcaggactt atgggtgctt
     6421 acggtgcggc tctttacgca aagaaaaagt caaagggcgt tggcaagagt acaattaccg
     6481 acaaaaaggg acttgatgaa ttcgttcacg aaatcaaggt tgcaaactgc ggtatgtgca
     6541 acaacaactg ccgtcttaca ataaattcat tcggcaaggg cagaaagttt gttgcaggaa
     6601 accgttgtga aagaccgatc acaaagaaag ctcctgcaaa cgatatgaat atgtatgcct
     6661 ataagctgaa tctcattgat tcctacaagc ctgttgaagg cataagaggt aagcttggaa
     6721 ttcctatggc gctcaatatg tatgagcttt atccgttctg gtacagattc tttacagaac
     6781 ttaaatttga ggtgttccac tcaccgtatt caacaagaaa gctttatcag agaggtcagc
     6841 agacaattcc gagcgatacc gtttgcttcc ctgcaaagct tgttcacggt cacattcaga
     6901 ctcttattga tatgggtgca gaaacaattt tctacccctg tctttcctat aattttgacg
     6961 agcatctcgg agataaccat tacaactgtc ctgttgttgc ttactatccc gaggttatca
     7021 aaaacaatat gaaggatata cgcaaggttc acttcataaa ggaatacttt ggtattcacc
     7081 gcccgaacga ttttccgaag aaagcctatg aaagactttc gttccacttc cccgacctca
     7141 ctcttaacga ggtaagaaat gcggctaagc ttgcatatca ggaacaggaa aattacagaa
     7201 aaaaggttat cgacaagggc agcgagatta ttgccaaggc tgaaaaagag ggcaaaaaga
     7261 tttttgttct tgcaggcaga ccatatcata ttgatcccga aattaaccac ggaatcgaca
     7321 gacttatctc aggctttgat gttgcaatcg tcagcgaaga tgttatttct ccgagagttg
     7381 aacatttccg gactcatgtt cttaaccagt ggacatacca cgcaagactt tatgcggcgg
     7441 caaaatatgt tacaacaaga aaggacatgg agcttgttca gcttgtatcc ttcggctgcg
     7501 gtgttgatgc gattacaacc gatgaggtaa gagaaattct tgaaagcaaa aataagattt
     7561 acactcagat taagatagat gaaattacaa acctcggagc agttaaaatc cgaatccgca
     7621 gtttgcttgc tgcgcttgaa aacgattgat gaaaggaaat tctgttatgg cagagttgaa
     7681 gtatgacaaa aaaacaggtc gtttgctgtt tacaaagcag atgaaaaagg aatacacaat
     7741 tcttatgccc aatatggcgc ctattcattt taaaatactt gaaaaggtgt tcaactacta
     7801 cggctataag tctgatttgc tcgacacaac gggtccggag attgcgcaga caggtcttaa
     7861 atatgttcac aacgatacct gttatccggc tttgctggtt ataggtcagt tcatcaatgc
     7921 tctgcaaagc ggaaagtatg atgttcacaa ggttgccctg atgattactc agacaggcgg
     7981 cggatgtcgt gcgtcaaact acattttcct tttgagaaag gctctcaaaa aggcaggctt
     8041 tgagttcgtt cccgtaattt cactttcgtt cggtatggag cacaacagcg gcttttcgct
     8101 cacacttccg cttatccgca gatttgtcgg cggtcttgtg tacggcgacc agttaatgct
     8161 gctttcaaat cagacaaagc cttatgaagt gaacaagggc gaaagtatgg cgcttgttga
     8221 tgagtggacg gataagattt ccgatatgct catacagggc aagggctaca ctcttgaaga
     8281 aattgacgaa actcttgacc gaattacaaa gtcatttaca aaaatagagc ttaacaaagt
     8341 gccgaaggtt aaagtcggta ttgtcggcga aatctatgta aaatactcca aaatggctaa
     8401 caacggtctt gaggactttc ttgcagatca ggattgcgag gtttgcgtac ccggtcttat
     8461 gggttttgca tcatttaagg ttgataaccg tattgaggac tacaagatgt tcggaggaag
     8521 cagagttaaa tacaaattct gttcgatgct tcttaactac ctcacaaagc ttgagggact
     8581 tatggttgat gccgctgaaa agtacggctt tgttccgcct cacagatatg ctcacacaaa
     8641 ggagcttgta aacggtgtta tcggctacgg cagtaagatg ggcgagggtt ggttgctgac
     8701 agccgagatg attgaacttg ccgatacagg ctatgagaat atcgtatgca cacagccttt
     8761 cggttgtctg ccgaatcata tcaacggtaa gggcgcaatc agaaagatta aagaaatcag
     8821 accgaatgcc aatatcgtta ccatcgacta tgatccgggt gcgccgaagg taaatcagga
     8881 gaaccgtatc aagctgatgc ttgctgtcgg caaagaggaa ctcaagaaaa agcttgaggc
     8941 tgaaaaaaat ggcgaaaaag ccgaatcgtc agagaagtca gagaaaaagt aatttaatat
     9001 caatgcttat gagtcatcgc agatggcggt ggctttttta ttttgcggta atatcaggca
     9061 gaaaaagcta atacaatttt acaggggttt atctcgtttt taaggaaaaa ataagtgtaa
     9121 aaatcggggg atattatgaa aaaacgactt aaaggatttt tcaaaggctt gcacggtggc
     9181 tgaatgtgcg tgaaatgcga cagcacaagg ttaaggcagg cgtttacatc attataaggc
     9241 tcatacttgt gtcacttttg actgccggca ttttaaacgg aaaatgggag aatgtcatga
     9301 cctgcgtgtt aacgctcgga ctgttgatgc ttccgttgtt catcgaccga aagctgtcgg
     9361 tagcgttgcc gagtgtgctt gaaacgattg ttgtgctgtt cgtgtttgcg gcaaatgtta
     9421 tgggtgagct cggtgcgttc tacgaaaaga ttccgatatg ggattcattg ctccatactg
     9481 tgaacggctt tatctgtgca ggcgttggtt ttggactgac cgatattttg aacagaagcg
     9541 agcgggtgaa attgagcctc tcgcccatgt ttgtgtgcct gttttcgttc tgcttttcaa
     9601 tgacagtcgg tgttgtgtgg gagttttttg agtttggtgc ggatatgctt tttgaaaagg
     9661 atatgcaaaa ggacaccgta atcacggcaa tacattcggg tttgatttcg ggcaagccga
     9721 atgtgataat gcacatcaga gatataacat caaccgttgt gaacggtgaa aatctcggta
     9781 ttaacggtta ccttgacatc ggtctgatcg atacaatgaa agatttgctt gttaattttg
     9841 taggagcggt agtttttgac accataggtt ggttttacct gaaaggaaga agtgcaggat
     9901 ttttgcggaa ttttatcccc gttaaaaaat aatgacgcaa tgtttatgta aaatcaaatt
     9961 atataaatga gttgcatatg atatttgaac gctatgcgtt caatcgtgtg catcgcacac
    10021 gaacgggcga acacggttca cccctgcaat tttttacttt taattttcaa ttagcaagag
    10081 ggcagtcaca ttgccgtgac tgccctcttg cttttggtga tattcttata ttaaaattac
    10141 ttatcttcct gaagtgtgat ttcaacctca ccgtcgcccg atgatgagct gtaatattta
    10201 accttgattt tgtcccccgg cttgtgggtt tcaagaatcg cataaacatc tgcaaagctt
    10261 gtaattgttt cgccgtcaac ctctgtgatg atatcgcctt cttcaaggct tgtgccgtca
    10321 cacgggccgc ccgatacgat actctgaaca taaatgccct gcggaatgtt gtaatttgat
    10381 gcctgatcgg aggttactgc aatgcccgaa atgccgattt ttactctgcc ttcaacatag
    10441 ccgttcttta caagtgtgtc aacaatgctt tttactgtct gtgacggaat tgcaaagccc
    10501 ataccttcgt aagtttcgga aacaatcttt gaagttgtaa ttccgacaac ctgaccgtag
    10561 tagtttacaa gcggaccgcc cgagttgccc ggattgattg cggcatctgt ctgaatgtac
    10621 tttgtaaggc ttgatgttga aagctttctg tcaagcgccg aaataacgcc cttggttgtt
    10681 gtgttctgat agtcaagacc gccgggattg ccgactacga taatatcctg accaacctca
    10741 agctgtgacg aatcgccgaa tgttgcaggg gtaagtccct ttgcatcgtc cattttgaga
    10801 actgcaatat cggttcttga atcgtaacct acaacacctg ccttgtattc cttgccgtca
    10861 gatgttacaa ctctgattgc ataggctgtt ttgctgttgc cgattacatg agcgtttgtg
    10921 ataacatagc cgtcctgtga gaagataatt ccgcttccct gtgaagatgc ggttgttgtg
    10981 tcagcctgat cgggtacatc gtccgagtaa cagagaatgc cgactaccga gtcggaaacc
    11041 ttttctgacg cttttgcggc tgtgtagctg ttgtttgttt ttgcgtcttt cggattgctt
    11101 tcaagcttca tacccgagta atccttgttc accttgtcac tgtagtcaga ctcatcgtga
    11161 gttttaccct gcgaagatgt gttgggaagg gtttcaaacg gtgttgtgct gtctttattc
    11221 ggaagtctga acgaattgcc cgaatcactt cggtcgttgt tcaaatcttc ttttatgtca
    11281 gccgaaaatc catacaccat catgccgata aaaccgattg taagaagtga acagagaacg
    11341 ataatcaacg caattattcc gccctttgtt ttcttttggg ggtactgtgc gaacatctga
    11401 ggattgtatt gctgattgta tgtaccgttg ttgccgtagg gaggctgtcc gtacatattc
    11461 tgctgatacg gaggtacatt ctgattgtat cctgtgttgt tttgatactg tccgtactgc
    11521 tgattgttct gattatactg cggattctgt ccgctgtagg gatactgacc gtaaccgtac
    11581 tgccacggct gagcgtaggt gttcggattc ggattttgat tctgctgata cggcggaaca
    11641 ttttcagtcg gatttgcatt gtttgccgta ttttgattgt tgttgccgaa aatataatca
    11701 ccgtaaggtg tgttgccgtt ctgcggctga acattctgag cctgttcttc ctgtgtttcg
    11761 ggttcggaaa cgggaattgt ctgttccgtg ttcatattat tgttttgtac gggcttttcg
    11821 gtgaacggct tttgcggttc aaacccaccc atattgttgt tgtcaaaatt gtccataaaa
    11881 gttactccta catttatttg ttaccgtggg gtacaaactg cgtttgtcct taagtaatga
    11941 aacaaaattt tttgcaagca aattgccgaa atgaacaaat atttcgtagg ggcagatatc
    12001 atccgcccgc cactatatcg gttgttttgt tatatttata aaactttgtt tgcaataaaa
    12061 tatctgtcat tacttacggt cgcaagacta cccctacggg atagtttaca aaaaatatta
    12121 tcatacaacg cttgaccaaa atcaagtatt gtaatttaca tttatattat ac
//
