LOCUS       gnlProkkaFLONLHCL_63    9947 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FLONLHCL_63.
ACCESSION   gnlProkkaFLONLHCL_63
VERSION     gnlProkkaFLONLHCL_63
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 11:08:08
            Original ID  :: gnl|Prokka|FLONLHCL_63
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9947
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..9947
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5534:7142]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5535..7142
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..9947
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9947
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             151..1050
                     /locus_tag="ctg63_1"
                     /transl_table=11
                     /translation="MKFCKYCGAQLEDNAVCNCEKSRAAQAQAQQANAQAQPQYQQPVQ
                     PQQPQYQNPVQQQYAQPQNPQTQQSPYAVNNTAPIGENAFVKALKNIPVVFTSFFKDSK
                     TVIKTAKAEKDIILGALFSAIFFIALILGNMFLMLSMSALDFPKTLLVSLVTTVLIGGF
                     YSVILFAYVKKYKTEENTAKAFIDSFITFSIESIPASIGWILAGLCALISVYMFLFFFV
                     IVMLYLVISLVNQVKANVPEEKNSALFTLILTLIVAVAFMIVFFIGAELTMWSFNTSTF
                     ATSVLTSLIGGGSYSSLY"
     CDS             complement(1110..2294)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg63_2"
                     /sec_met_domain="PF04055 (E-value: 1.3e-20, bitscore: 63.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFPIFSYTFQIEAETCVSASKSFMRFFMSNSIGLYIHIPFCKHK
                     CPYCDFFSGNADENAFDNYVIELKDKIKYWSEKAKRDVATVYFGGGTPSVLGADRLCDI
                     LDFIKFNFNIQNNAEITVEVNPDSAKTIDFEKMYACGFNRISMGMQTAVEDELRLLGRI
                     HSIDDAKISVQRAKSAGFNNISLDLMMGIPNQTIESLEKSISFCADCKVTHISSYILKI
                     EENTPFYKVQNKLKLADDDMQAEMYLKAVEMLDSLGYKQYEISNFAKQGYESRHNTNYW
                     RCGEYIGIGPSAHSFFEGKRFFYSRSMDDFNNNKLSFEGTGGDEEEFIMLSLRLKSGLN
                     YYEFEEKFGYTLPSYIIKKAKEYEKYGYTNVTDKSISFTPKGFLVSNSIISELI"
     CDS             2460..4046
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190:GTP-binding protein LepA (Score: 109.2; E-value:
                     4e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg63_3"
                     /transl_table=11
                     /translation="MSSFKEEISKRRTFAIISHPDAGKTTLTEKLLLYGGAINLAGSVK
                     GKRTAKHAVSDWMEIEKQRGISVTSSVLQFKYNGYCINILDTPGHEDFSEDTYRTLMAA
                     DSAVMVIDGSKGVEKQTIKLFKVCVMRNIPIITFINKMDRDAKNSFDLLEDIENVLGIH
                     TYPVNWPIGSGKEFKGVYDRNSKKILAFTANNGQKEVEKKELTLDDPALEDTIGYYHKQ
                     DLFDEIELLDGAGDEFDLEAVRNGQLTPVFFGSALTNFGVEPFLEQFLQLTTPPLPRET
                     VDEKVEPMSDFFSAFVFKIQANMNKAHRDRVAFMRICSGKFEKNMEVFHVQGNKKMRLS
                     QPQQIMAQEREIVDEAYAGDIIGVFDPGIFSIGDTICSPGHKVRFRGIPTFAPEHFALV
                     RQKDTMKRKQFIKGTSQIAQEGAIQIFQELDAGMEEVIVGVVGVLQFDVLKYRLQNEYN
                     CDIIMETLPYEFIRWIVNDDLDPKTLDLASDTKKIQDLKGNHLLLFTSYWSINWALEHN
                     KGLELAEFGTN"
     CDS             4070..5473
                     /NRPS_PKS="Domain: Aminotran_5 (54-217). E-value: 4.4e-13.
                     Score: 40.7. Matches aSDomain:
                     nrpspksdomains_ctg63_4_Aminotran_5.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg63_4"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.1e-12, bitscore:
                     36.8, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 8.2e-10,
                     bitscore: 27.5, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 7.4e-14, bitscore:
                     40.4, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYDKLKNYSKSGIYPFHMPGHKRTDITEEGIIPYNIDITEIHDF
                     DNLHSPNGVIDEIQKKAAKLYNAKNAFILINGSTGGILSAIRSMTNQGDKILMARNCHK
                     SVYNSAELFNLNVDYIFPDTDSRYNILTSVSPCDIEDKLTKHNNEIRLVIITSPTYEGV
                     VSDIKSISEICHKHGAKLLVDEAHGAHFPFSDSFPDEALNCGADAAVLSLHKTLPSLTQ
                     TALLITNDSELSEIFAENLAVFETSSPSYILMSSIEKCLDFCENSKDKFKEYCCNLKTV
                     REKLKNLKYLKIYDKSDTDFDYDIGKIVISTANANISGTKLAEILRNNYQIETEMAYSD
                     YVIAMTSVCDTEKAFDMLSDALISIDSELSKGADTERVPLKNLYTGKNFNACELYKFNK
                     ETIPFQNSEFRTSAEYIWAYPPGIPLIVPGEIISKELINYIEYLSACKVEIMSTKGGMT
                     NYISVVKKD"
     aSDomain        4232..4720
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg63_4_Aminotran_5.1"
                     /evalue="4.40E-13"
                     /label="ctg63_4_Aminotran_5.1"
                     /locus_tag="ctg63_4"
                     /protein_end="217"
                     /protein_start="54"
                     /score="40.7"
                     /tool="antismash"
                     /translation="IDEIQKKAAKLYNAKNAFILINGSTGGILSAIRSMTNQGDKILMA
                     RNCHKSVYNSAELFNLNVDYIFPDTDSRYNILTSVSPCDIEDKLTKHNNEIRLVIITSP
                     TYEGVVSDIKSISEICHKHGAKLLVDEAHGAHFPFSDSFPDEALNCGADAAVLSLHKTL
                     "
     CDS             5535..5687
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_5"
                     /sec_met_domain="TIGR03973 (E-value: 1.1e-27, bitscore:
                     84.9, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 5.2e-27, bitscore: 82.7,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIKTIETRDLKKSVKTGGCGECQTSCQSACKTSCGVANQQCEK
                     CMSEK"
     CDS             5769..7142
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_6"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.1e-31,
                     bitscore: 98.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.8e-15, bitscore: 46.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.8e-15, bitscore: 46.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 6.4e-21, bitscore:
                     63.8, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYKLNGYNIVLDVYSGSVHAVDDLAYDVIAMYKNATKEQIID
                     EMLSKYADNPEITKEEISDCIDDVKELEKQGKLFTDDKYENLAFDFKKRNTVIKALCLH
                     IAHTCNLNCEYCFASQGKYHGERALMSFEVGKRAIDFLIENSGSRVNLEVDFFGGEPLM
                     NFDVVKQIVAYARSIEKEHNKNFRFTLTTNGMLVDDDVIEFANKECHNVVLSLDGRKEV
                     HDHLRKTVNGKGSYDIIVPKFQEFVKKRGNKGYYVRGTYTHNNTDFTNDIFHMADLGFT
                     ELSMEPVVCAPDDPYALTYDDLPILFEQYEILAKEMLKREKEGRPLTFYHYMIDLTGGP
                     CIYKRISGCGSGTEYMAVTPWGDLYPCHQFVGDEKYKLGDIFNGVSNTKIQDEFKLCNA
                     YARPDCKDCWARLYCSGGCAANAYHATGSITGIYEYGCELFRKRMECAIMMKVAEAEE"
     CDS             7208..8017
                     /locus_tag="ctg63_7"
                     /transl_table=11
                     /translation="MNEKIIMLGTGSAMVTDCYNTCFLLKSENDCLLVDAGGGNGILSA
                     IKKSGVAWNSIKTMFITHSHTDHILGAVWVIRQISALMNSGKYDGNFNIYCHDECVDSI
                     TAICNHTLAPKFLKNINTKIFINEVKDSEKQNAGSIQLTFFDIFSDKTKQFGFKAVFPS
                     GKVLACLGDEPFNEKCRNFVQNCDYLMCEAFCLYSQKDIFKPYEKFHSTALDAGKLAES
                     LFAKNLILYHTEDETLQTRKRTYTSEARTVFNGNIFVPDDFEVIDLK"
     CDS             complement(8009..9922)
                     /locus_tag="ctg63_8"
                     /transl_table=11
                     /translation="MFSTDKSSFNKKDVSDCDYKISLAGNPNVGKSTIFNELTGLRQHT
                     GNWTGKTVDFARGCCKIKDARFCITDLPGCYSLLSFSGEEAVTRECLIQNQNDCVVIVV
                     DCGVIERNLSFALQVLSVTKNAVLCLNLCDEAEKNGIKIDCDELSLNLGIPVVKTCATD
                     KKGLDELKEAIYDVCSGKTKCFRVKRNFEGVDILSEKNYKQNIEKLSQIGNKISSDCVK
                     YEKSELNACTRKLDKILTSKAAGIPIMLAMLGILFWITVVGANYPSEWLSNLFGFIKEK
                     LYILFDFLHAPDVVTGLLIDGVYTTLSWVVSVMLPPMAIFFPLFSLVEDSGYLPRIAFN
                     LDRHFSKCGAHGKQSLTMAMGLGCNACGVTGCRIIESPKERLIAILTNNFMPCNGRFPT
                     IIALLLMFFAGTAFTLSSSLEVAALLIGIIVFCVFITLVISKVLSVTILKGEQSGFVLE
                     LPPYRKPQILKTIVRSLLDRTLFVLGRAVAVAAPAGAIIWILANVHISDISLLKYCTDF
                     LDPFGRFIGVDGVIIMAFILGFPANETVIPIIIMSYMASGTLVDYSSYDQLFQLLSMNG
                     WTITTAVCTIILCILHYPCSTTCLTIKKETGSLKWTLVSMALPTAMGIVLCMITAGVMR
                     LF"
ORIGIN
        1 gtagtgtaaa aaattaaaaa attgtaagaa atattgaatt attgctgtaa tttggatata
       61 atgtgagcgt tgatgttatc acttctcaat aaacaaacaa caggtagcta taagacctgt
      121 tacatattat tttatcttgg aggaatcacc atgaaattct gtaaatattg cggagcacag
      181 cttgaagaca atgctgtttg caactgcgaa aagtcaagag ccgctcaagc acaggctcag
      241 caggcaaatg cacaggcaca gcctcagtat cagcagcctg ttcaaccaca acagccacag
      301 tatcagaacc ctgttcagca acagtatgca cagccgcaaa accctcagac acagcagtcg
      361 ccttatgccg taaataacac agcacccatt ggggaaaatg cttttgttaa ggctttaaag
      421 aacattcctg ttgtgttcac ttcattcttt aaggattcca aaactgttat caaaacagca
      481 aaggctgaaa aggacatcat tctcggcgct cttttctcgg caattttctt tattgcactc
      541 attcttggca atatgtttct tatgctttct atgagcgcac ttgattttcc gaaaacactt
      601 cttgtaagtc ttgttactac tgtccttatc ggcggcttct attctgttat tctctttgca
      661 tatgtaaaga aatacaaaac cgaagaaaac acagccaaag catttattga ttcattcatc
      721 acattttcaa ttgaatctat tccggcatca atcggttgga ttttggcagg tctttgcgct
      781 ttaatcagcg tatatatgtt cctgttcttc ttcgtaatcg ttatgcttta ccttgttatt
      841 tcacttgtaa atcaggtaaa agctaatgtt cccgaagaaa agaactctgc attattcact
      901 ttaattctca cactcatcgt tgccgttgca tttatgattg tattcttcat cggcgcagaa
      961 cttactatgt ggtcatttaa cacaagtaca tttgcaacaa gtgttcttac atcgcttatc
     1021 ggcggcggtt catactcttc attgtattaa tctgacatac aaattcataa cataaaatta
     1081 acgctccgaa tttattctcg gagcgttttt tatatcagtt cactgattat tgaatttgaa
     1141 acaagaaaac ctttcggtgt aaagcttatt gacttgtccg taacatttgt atagccgtat
     1201 ttttcatact ctttagcttt tttgataatg taagagggga gggtgtatcc gaatttttcc
     1261 tcaaattcat aataattaag accgcttttc agcctgagag agagcataat aaattcctcc
     1321 tcatctccgc ccgtaccttc aaaagacagc ttattgttat taaaatcgtc catgcttctc
     1381 gaataaaaga accttttgcc ctcaaaaaat gagtgtgcag acggacctat gccgatatat
     1441 tcaccgcatc tccagtaatt ggtattatgt cggctttcgt aaccctgttt tgcaaaatta
     1501 gaaatttcat attgcttgta tccgagagaa tcaagcattt caacagcttt cagatacatt
     1561 tcagcctgca tatcatcatc ggcaagctta agtttatttt gcaccttata aaacggagta
     1621 ttctcctcga ttttcaaaat gtatgatgaa atatgagtaa ctttgcaatc ggcacagaaa
     1681 ctgattgatt tttcaaggct ttcaattgtc tgattaggga ttcccatcat caaatcaagt
     1741 gaaatattat taaatcccgc acttttagcc ctttgaacag aaatctttgc atcatcaatg
     1801 ctgtgaattc tcccaagcag ccttaattca tcttcaacag cagtctgcat tcccattgaa
     1861 atgcgattga atccgcaggc atacattttt tcaaaatcaa tagttttggc ggagtcggga
     1921 ttgacttcaa ccgtaatctc ggcattattt tgaatattaa aattaaactt gataaaatca
     1981 agaatatcac aaagtctgtc tgcacccaaa acactcggcg taccgccgcc gaaatatacg
     2041 gttgcaacat ctcttttggc tttttcagac cagtatttta ttttatcttt taattcaatc
     2101 acataattat cgaaagcgtt ttcatctgca ttgccgctga aaaaatcgca atacggacat
     2161 ttgtgcttac aaaacggtat gtgaatgtaa agaccgatag aattactcat aaaaaacctc
     2221 ataaatgatt ttgaggcaga aacacaagtt tctgcctcga tttggaaggt atatgaaaaa
     2281 ataggaaaaa tcacattaag tccttctgta ccaatatatt acaatatatt tacaaatttg
     2341 tcaagttttt gtagcaatta tttttctcac attttcttca ttctttattg acatatacca
     2401 tccaaaaata gtaaaatata gaattgtgga tatacttaac ctccgaaagg aagaaagata
     2461 tgagttcatt taaagaagaa atcagcaagc gcagaacctt tgcgattatt tcgcatcctg
     2521 atgcgggtaa aacaacactt acggaaaagc tcttgctcta cggcggagca attaaccttg
     2581 caggttcggt aaaaggcaaa agaaccgcaa agcatgctgt gtccgactgg atggaaattg
     2641 aaaaacagcg tggtatttct gttacatcat cggttttgca gtttaaatat aacggttatt
     2701 gcataaatat tcttgacaca ccgggacatg aggacttctc tgaagatacc taccgtacac
     2761 ttatggcggc agactctgcc gtaatggtaa ttgacggttc aaagggtgtt gagaaacaga
     2821 ctatcaaact tttcaaggtc tgtgtaatgc gtaatattcc tatcattaca ttcatcaaca
     2881 agatggacag agatgcaaaa aattcttttg accttcttga agacattgaa aatgttctcg
     2941 gaattcacac ctatcctgta aactggccaa tcggttcagg taaggaattc aagggtgtgt
     3001 atgacagaaa ttctaagaaa atccttgctt tcaccgctaa taacggtcag aaagaagttg
     3061 aaaagaaaga acttacgctt gacgatcctg cccttgaaga tacaataggc tactatcata
     3121 agcaggattt gtttgatgaa atagaacttc ttgacggtgc aggcgatgaa tttgaccttg
     3181 aagcagtccg caacggtcag cttactcctg tattcttcgg ttcggctctt acaaactttg
     3241 gtgttgaacc attccttgaa cagttcttac agctcacaac tccacctctg ccaagagaaa
     3301 cagttgatga aaaggttgag cctatgtcag actttttctc tgcatttgtc ttcaaaattc
     3361 aggcaaacat gaataaggct caccgtgaca gagttgcatt tatgcgcatc tgcagcggca
     3421 agtttgaaaa gaatatggaa gtgttccatg ttcagggcaa caaaaaaatg cgtctttcac
     3481 agccacagca gattatggct caggaaagag aaattgttga cgaggcatat gcgggcgaca
     3541 tcatcggtgt gttcgatccg ggcattttct caatcggtga cacaatctgt tcaccgggac
     3601 acaaggtacg gttcagggga attcctacat ttgctcccga acactttgca cttgtccgtc
     3661 agaaagacac aatgaagcgc aaacagttca tcaagggtac aagtcagatt gcacaggaag
     3721 gtgcaattca gattttccag gagcttgacg caggtatgga ggaagttatc gttggcgttg
     3781 taggcgtact tcagtttgat gttcttaaat acagacttca aaacgaatac aactgcgata
     3841 tcatcatgga aacactccca tatgaattta tccgttggat tgtaaacgat gaccttgatc
     3901 cgaaaactct cgaccttgca tccgatacta agaaaattca ggaccttaaa ggcaatcatc
     3961 ttttgctctt tacaagctac tggagcataa actgggcgct tgaacacaac aagggacttg
     4021 aactcgctga gttcggtaca aactaaatat ttaaaatatc ggaggatata tgctgtacga
     4081 caagcttaaa aattattcaa aaagcggcat atatcctttt catatgcccg gacataagag
     4141 aacggacatt acagaagagg gtataatacc gtataatatc gacataaccg aaattcatga
     4201 ttttgacaat ctccattcgc caaacggagt tattgatgaa attcagaaaa aggctgcaaa
     4261 actttacaat gcaaaaaatg ctttcattct gattaacggt tcaacaggcg gaatactttc
     4321 agcaattcgc tcaatgacaa atcaaggcga caagatctta atggctcgta actgccacaa
     4381 atctgtatat aattcagcag aactgtttaa tctcaatgtc gattacattt ttcccgatac
     4441 agacagcaga tacaatattc ttacatcggt ttcaccttgc gatatagaag ataaacttac
     4501 aaaacacaat aatgaaatca gacttgtaat cataacttcg cctacatatg aaggagttgt
     4561 ttcggatata aagtcaatct ccgaaatctg tcacaaacac ggagcaaaat tacttgttga
     4621 cgaagctcac ggagcgcatt ttccgttttc ggacagtttt cccgatgaag cacttaactg
     4681 cggtgcagac gccgcagtat tgagtctgca caaaactttg ccgtcattaa ctcaaactgc
     4741 attgctcata acaaatgaca gcgagctttc tgaaattttt gctgaaaatt tagctgtatt
     4801 tgaaacaagc agtccgtcat atattttaat gagttcaatt gaaaaatgtc ttgatttctg
     4861 cgaaaacagc aaagataaat tcaaggaata ttgttgcaat cttaaaacgg tcagagaaaa
     4921 acttaaaaat ctgaaatatc tgaaaattta tgataaaagc gatactgatt ttgattatga
     4981 tatcggcaaa attgtaattt caacagcgaa cgcaaatatt tcgggaacaa agcttgccga
     5041 aatactgcga aataattatc agattgaaac cgaaatggca tattcggact atgtaattgc
     5101 catgacatct gtttgtgaca ccgaaaaagc ttttgatatg ctttcagacg ctctgatttc
     5161 aattgacagc gaactttcaa aaggagccga caccgagcgt gttccgttaa aaaatctcta
     5221 tacaggtaaa aatttcaatg cctgcgagtt gtacaaattc aacaaagaaa ctattccgtt
     5281 tcaaaattcg gaattcagaa cttctgccga atatatctgg gcatatccac ccggaattcc
     5341 cctcatcgta cccggtgaaa ttataagcaa ggaacttata aattacattg aatatctttc
     5401 agcctgcaag gttgagatta tgtcaacaaa aggcggtatg acgaactaca taagcgtagt
     5461 taaaaaagat tgacaaatca atgactgtgt gataatatta aactaacaaa atctaacaag
     5521 gagtttgatt tattatgaag agaattaaaa ctatcgaaac tcgtgacctt aagaagagcg
     5581 ttaagacagg cggttgcggc gagtgccaga cttcatgcca gtcagcttgt aagacatctt
     5641 gcggcgttgc taaccagcag tgcgaaaagt gcatgagcga gaaataattc tattttaatt
     5701 tgattattaa ggattatcgc cgttttccca aagggttaac ggctttcctt ttgtctaatg
     5761 gagatattat gattcatcag tataaactta acggatacaa catagttctt gatgtttaca
     5821 gcggcagtgt acacgcagtc gatgaccttg cttatgatgt tattgcaatg tacaaaaacg
     5881 caacaaaaga acagataatc gacgaaatgc tttcaaaata tgcagacaat cctgagatta
     5941 caaaagaaga aatctccgac tgcattgatg atgtaaaaga gcttgagaaa cagggaaagc
     6001 tctttacaga cgacaagtat gaaaaccttg catttgactt taaaaagaga aacacagtaa
     6061 tcaaagcact ttgtctgcac attgctcaca cctgtaacct taactgcgaa tactgctttg
     6121 caagtcaggg caaataccac ggcgagagag cgcttatgag ctttgaagtg ggcaagagag
     6181 caattgactt tctcattgaa aattcaggca gcagagtaaa ccttgaggtt gacttcttcg
     6241 gcggagaacc tcttatgaac tttgacgttg taaagcagat tgttgcctat gcaagaagca
     6301 ttgaaaagga acacaacaaa aacttccgtt ttacacttac aacaaacggt atgcttgttg
     6361 atgacgatgt aattgaattt gcaaacaaag aatgtcataa tgtagttctt agccttgacg
     6421 gcagaaaaga agtgcatgac catcttcgca aaactgtaaa cggcaagggc agttacgaca
     6481 ttatcgttcc gaaatttcag gaatttgtca aaaaaagagg caacaagggt tactatgtaa
     6541 gaggcactta cacacataat aacacagact tcacaaacga tattttccat atggcggatt
     6601 tgggatttac agagctttca atggagccgg ttgtatgtgc tcccgatgac ccatatgcac
     6661 ttacatatga cgatttgcct atcctttttg aacagtacga aattcttgca aaggaaatgc
     6721 tcaagcgtga aaaagagggc agaccactca ccttctatca ttacatgatt gaccttacag
     6781 gcggtccgtg catttataag agaatctcgg gttgcggttc gggtacagaa tatatggctg
     6841 taacaccttg gggcgacctc tatccctgtc atcaatttgt aggcgatgaa aagtacaagc
     6901 tcggcgatat ctttaacggt gtttcaaaca cgaaaattca ggacgaattt aagctttgta
     6961 acgcatacgc ccgtcccgac tgcaaagact gctgggcaag actttattgc agcggcggtt
     7021 gtgccgcaaa cgcttatcac gcaacaggct caatcacagg tatttacgaa tacggctgtg
     7081 agcttttcag aaaaagaatg gaatgtgcca ttatgatgaa ggttgcagaa gcggaagaat
     7141 aaaattacaa taaatttttc aggcagatac atttttcttg tatctgcctg tattttcgag
     7201 gtgctgtatg aacgaaaaaa ttattatgct cggtacagga agtgcgatgg ttaccgactg
     7261 ttataatacc tgttttcttc tgaaatccga aaacgactgt cttcttgttg acgcaggcgg
     7321 cggaaacgga attttatccg caattaagaa atccggagta gcttggaaca gcataaagac
     7381 aatgtttatt actcattctc acaccgatca tattttaggt gccgtgtggg taataaggca
     7441 aataagcgct cttatgaatt caggcaaata tgacggtaat tttaatattt actgccacga
     7501 tgaatgtgtt gattcaatca cggcaatttg caaccacaca cttgcaccga aatttctcaa
     7561 aaatatcaat acaaaaattt tcatcaatga agtaaaagac agcgaaaaac aaaatgccgg
     7621 cagtatccaa ctcactttct ttgatatatt ttcagacaaa acaaagcaat tcggattcaa
     7681 ggctgttttt ccgtcaggaa aagttctcgc ctgtctcggt gatgaaccgt tcaatgaaaa
     7741 atgcagaaat tttgttcaaa actgtgatta tcttatgtgt gaagcttttt gtctttacag
     7801 tcaaaaagat atttttaagc cctacgaaaa attccacagc acagcgcttg atgcaggaaa
     7861 acttgcagag agtctttttg caaaaaatct tatcctgtat cacaccgagg acgaaacact
     7921 tcaaacacgc aaaagaacat atacttcaga ggcaagaaca gtttttaacg gaaatatatt
     7981 tgttcccgat gattttgaag ttattgactt aaaataatct cataacacct gctgtaatca
     8041 tacaaagcac aattcccatt gcagtaggca atgccataga aacaagcgtc catttaaggc
     8101 tgcctgtttc tttttttatt gtcagacagg ttgttgaaca cggataatga agaatgcaaa
     8161 gaataatcgt gcatacagcc gttgtgatcg tccagccgtt catactgagt agctgaaaca
     8221 gctggtcgta gcttgaataa tcaacaagag taccgcttgc catatatgac ataattataa
     8281 tcggaataac ggtttcattc gcaggaaatc caagtataaa tgccattatt ataacaccgt
     8341 caaccccgat aaatctgccg aacggatcta aaaaatcagt acaatatttt aaaagtgaaa
     8401 tatcgcttat atgcacattt gcaagaatcc agattatcgc acctgccgga gcggcaaccg
     8461 caacagccct tcctaaaaca aataaagttc tgtccaacag cgaacggacg atagttttta
     8521 aaatctgcgg ttttctgtac ggcggaagtt caagcacaaa tccggactgt tcacctttca
     8581 atattgtgac tgaaagcacc ttagatataa caagtgttat aaaaacgcag aaaactatta
     8641 ttccaatcaa caatgctgct acctcaagcg aactgctcag cgtaaatgcc gtacctgcaa
     8701 agaacattag cagtaatgca ataattgtgg gaaaccgtcc gttacacggc ataaaattat
     8761 ttgtaagaat tgcaatcagc cgttcctttg gcgactcaat aattctgcat cccgtaactc
     8821 cacaggcatt acagccaaga cccattgcca ttgtaaggct ctgctttccg tgagcaccgc
     8881 actttgaaaa atgcctgtca agattaaatg caattctcgg cagatatccc gaatcctcaa
     8941 caagcgaaaa tagcggaaag aatatagcca taggcggcag cattacagat accacccatg
     9001 acagagttgt ataaactccg tcaatcaaaa gtcccgttac aacatcggga gcgtgtaaga
     9061 aatcaaaaag gatatacagc ttctctttta taaagccaaa caaattgctt aaccattcgc
     9121 tcggataatt tgctccgaca accgttatcc agaacaatat gccaagcatt gcaagcataa
     9181 tcggtattcc tgcggctttg cttgtaagta ttttatcaag ctttcttgta caagcattta
     9241 actctgattt ttcatatttt acgcagtcac ttgaaatttt gttaccaatt tgcgaaagct
     9301 tttcaatatt ctgtttgtag tttttttcgg atagtatatc aacaccttca aaattccttt
     9361 ttaccctaaa acattttgtt tttccactgc atacatcata gattgcttct tttaattcat
     9421 ccagaccttt tttgtctgtt gcacaggttt ttacaacagg tattccgagg ttaagcgata
     9481 actcgtcgca gtcgattttt atgccgttct tttcagcctc atcacaaaga ttaagacaaa
     9541 gaacagcatt ctttgtgaca gataatacct gcaatgcaaa cgaaagattt ctttcaataa
     9601 ctccgcagtc aacaactatt acaacgcagt cattttgatt ttgtataagg cactcccttg
     9661 ttaccgcctc ttcgcccgaa aatgaaagca gggaatagca tcccggtaag tccgtaatac
     9721 aaaatcttgc gtctttgatt ttgcaacaac ctctggcaaa atcaactgtt ttgcccgtcc
     9781 agtttcccgt gtgctgtctt aatcctgtca gttcgttaaa aattgtactc ttgcctacat
     9841 taggattacc ggcaagtgaa attttgtaat cgcaatccga tacatccttt ttattaaaag
     9901 atgatttatc cgtagaaaac aataaatagc ctccttttat tcaggag
//
