LOCUS       c00004_gnlPro..        13668 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FLONLHCL_4.
ACCESSION   c00004_gnlPro..
VERSION     c00004_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 17:42:48
            Original ID  :: gnl|Prokka|FLONLHCL_4
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 34841
            Orig. end    :: 48509
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13668
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[44841:48069]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13228
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13668
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13668
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             648..1190
                     /locus_tag="ctg4_44"
                     /transl_table=11
                     /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIYTATDGEVI
                     FKKYSPVGELAEFASQYADVLAKISSMPTIITDRDHVIAAAGVSKREFLERRVTAVLEG
                     YMENRKTYSATQQTLGDIQPIEGIEHYASVIYPIIAAGDVSGAVVMLTGEQTKIPSNAE
                     IKLAQTAAAFLGKQMEE"
     CDS             complement(1353..1853)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_45"
                     /sec_met_domain="Isochorismatase (E-value: 8.5e-31,
                     bitscore: 99.3, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTLIVIDMQNDFIDGSLGTAEAVKIVPNVRKKIEEYRSNGDEI
                     IFTRDTHGEDYLSTPEGKKLPVVHCVKNTHGWQIADGLDVPDAIHIDKPSFGYTHWDKF
                     CFEKIELVGLCTDICVVSNALILKALFPNAEISVDSACCAGVTPETHNSALATMKMCQV
                     DVV"
     CDS             complement(1859..3601)
                     /locus_tag="ctg4_46"
                     /transl_table=11
                     /translation="MALDGIFLRHIKTEIEKEALGARVSQIYQPNREELVFGLRTFSGN
                     KKLLLSARANSPRVNFCSSTPENPAQPPMFCMLLRKRIGGGKLVGLRQNGCDRVLMLDF
                     ECVNELGDTVMITVVCEIMGMYSNIIIVDSNGVIIDSLKRVDLTMSSKRLVLPNIKYEL
                     PESQNKLNLLKCTALDVCTAVKNLDTEMPLNKALLRTIEGASPIVCREIEYKVMEGATN
                     RIEGVLFDRLAVEIERLKSICSDCSGKPVVVYREDGKPMDFCFMNVEQYGDFAKVESKE
                     SFSDLLDGFYEARDSRDRMRVKSQSLTKLLNNTLERLARKIAKQKSELERCADREHLRI
                     CGDLLQANIYRIERGAEYVDVENFYDENNAILRIKLNPAISPSANAQKYYKDYRKAKNA
                     EIMLKEQLEKGREELDYIDSVLDTVDRAENEKDIAQIREELTEQGYLKVQKGKKPRQTT
                     LPPLEFESSDGFKILVGRNNRQNDKLTLKTASKNDMWLHTKDIHGSHVIVVSDGKKISD
                     TAICEAAQLAAYHSKARNSSQVPVDYTLVRYVSKPNGSKPGMVIYVNNKTLYVKPSQFK
                     IKTE"
     CDS             complement(3616..4101)
                     /locus_tag="ctg4_47"
                     /transl_table=11
                     /translation="MIKINIICIGKIKEKYFTDAIAEYAKRLTAFCKFNIIELSEERIK
                     SNIPNRSQIDEVIFSEGKRIMQKISPSDYVVAMCIEGKPMSSEELSTLIDNASVSGKST
                     VDFIIGGSYGLDESVKKRADVRLSMSRMTFPHQMARMILSEQIYRAFEISSNGKYHK"
     CDS             complement(4123..4911)
                     /locus_tag="ctg4_48"
                     /transl_table=11
                     /translation="LARAVPLFSGSKGNSYYIGSATEGVLIDAGRSCKQIENAMLANGL
                     DMSSIGAVFITHEHTDHCSALRVLAKRYGFKVYSSLGTLNALRAGNKLDPNTDADVITD
                     EVVIGNMRVQRIDTPHDAAESCCYRVTAPDGKSALIATDMGVMLPDVRTAAEQSDFVVL
                     ESNHDINMLKNGIYPYPLKQRILSNRGHLSNEACAKELVNLVEKGTLRLMLGHLSEENN
                     TVPLAMSTSVDLLTSNGMKYKSDYSLDVAPSVSTTKAIIF"
     CDS             complement(5036..6328)
                     /locus_tag="ctg4_49"
                     /transl_table=11
                     /translation="LEKFVVTGGKPLSGEVTISGAKNAAVAIIPAVILCDEPCQIENIP
                     NISDVSLISRILQQMGANVRRINRSSLYIDPTKIRTCNAVTDLVRGMRASYYLLGALLG
                     KYGRAKVALPGGCNFGVRPIDQHLKGFEALGAATQLVDGAIIEAECDNLVGTHVYLDVV
                     SVGATMNIMLAASKAKGQTIIENAAREPHIVDLANFLNSMGADVRGAGTDVIKIRGVEY
                     LHGVTYSIIPDQIEAGTYMCAAAATRGCITVKNITPKHLESISAKLREMGVKITEYDEA
                     LKVDASSAPLKRCNIKTMPHPGFPTDCQPQFAALLMSVPGTSIINENVWDNRYQYVSEL
                     IRMGAQISVEGRLAIIEGGTPLTAAPVKATDLRAGAAMIIAALEINGTTEISNIQFIER
                     GYEDVVEKFRGLGADIKKVYFTGDNEQELGA"
     CDS             7048..7365
                     /locus_tag="ctg4_50"
                     /transl_table=11
                     /translation="MENKEKTTTPEMPDIDVLFELADLFKVFGDSTRLRIMYTISENEM
                     SVLNIAEALSMEQSTISHQLRVLRQNKLVRVRREGKQIYYSLDDDHVKRIIEMGLDHVL
                     E"
     CDS             7376..9700
                     /locus_tag="ctg4_51"
                     /transl_table=11
                     /translation="MRYKYQLDNLNCAHCAGKIEAKIAETNGFEDVNFNFATKLLNFKS
                     ERQNPVSEIQAICDSIEDGVTVVDKTPKTNLKKYTYTLDNLNCAHCAGKIEAKIAETDG
                     FEDVSFNFATKLLNFKSEKQNPVSEIQAICDSIEDGVTVVDKTPKNDITTKPEPEITKK
                     KINRDTIFLAISIVLAVVSEILHLTLDGVTAVHYVVLAACFVATLLSGYKVFIKGAKNI
                     LKLRIDETTLMSVAVIAAFCLGDFVEAAMVTILFSIGEIFEDRAVDASRRDIEKLANIR
                     PDTATIIVDGAEQIVPAESVEIGSIIEVKPYERVPLDGIIIKGKTTLDTSALTGESLPV
                     DAGEGSEVLSGAINGSNLITVKTTKHFGDSTATRILQLVEDAAAQKGNSEKLISKFASV
                     YTPVVVLIAVAIAVIPPLCGLGAFSEWLYRALVCLVASCPCAIVISVPLSYYSGIGAAS
                     EVGVLIKGGKYIEALAKADTFVFDKTGTLTSGKLSVNKVNTVGSYSADEVLALAAASEK
                     YSAHPIASAIREKANGLELPELSDYSESAGHGTSAVYNGKTIQCGGSKILSDEEKKIAN
                     KDDSVFVIYDGQLIGSLNVSDTVRPEAKEVISQLKALGVKNTVMLTGDRQQPAENVKNE
                     LGLSECHAELLPAQKLELFKGLKSKSKGACFVGDGINDAPVLSASDCGIAMGFGSEAAI
                     EASDAVLASGTLKQLPKAIKIARSVINTVKGNIIFALSIKALVIILAAFGLAQIWMSVI
                     ADTGVSVVCVLIAARLLKKKY"
     CDS             10001..11623
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_52"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-42, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKIYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             11636..12127
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_53"
                     /sec_met_domain="ALS_ss_C (E-value: 1.8e-29, bitscore:
                     93.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQEPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRVNTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             12188..13228
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_54"
                     /sec_met_domain="IlvN (E-value: 1.9e-83, bitscore: 269.8,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.4e-60, bitscore: 194.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLR
                     DSGCDVIVGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKIAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(13407..13667)
                     /locus_tag="ctg4_55"
                     /transl_table=11
                     /translation="MYSSRGVVEESNNIYYRYFDGNDKNISRAKYNEINLKQFNNCVNA
                     HMFTEFIAIGYGDTSVWGENTTAENKQSLLDAYNSFSYEKY"
ORIGIN
        1 gcagtgttga tgcaagactt cttgacgctc ttgctacata tggatattcg tcaaggcaaa
       61 ggacgattct tttgttctct gacaatttaa aaacatattc aagtgccgac tgaaagtttg
      121 aaaaagcagt atccgttttc atccctgttg aaaattcaag aatacactcg ctcaaatttt
      181 caagattttg ctttgcattt gtttcaactc ctgtgaaaca aattgcgttt ttatccttga
      241 caaactcgtt tatgatagcc gtttttccca cacggcggcg accgtatatg acggcaaatt
      301 caaattttcc gctgttatac aatctgttaa gctgtaaaag ctcatacttt ctgcctataa
      361 acaaaattct cacctctgac cgtttgcaaa ttactcatct acaatttagt tatttacgat
      421 taactaaatt ataaaccact gtttttgcta agtcaagatt attttgcaat ttaggtggtt
      481 acgattaact aaatcgtgat aaagttatat tctttatatg ttgtaaaaat atgtcaccaa
      541 agaaaatttc ggtataaaaa actgtatgaa tcaaacaata ttactgcaaa taatttgctg
      601 aatatgtatc agacaaggga cagaactgtc cgaagggagt tttaaatatg aaagcaacag
      661 gaatcgtcag aagaatcgac gatctcggca gagtggttat accgaaagaa atcaggcgga
      721 cgcttcgtat tcgtgaggga gatccgctcg aaatttatac cgcaacggac ggcgaggtta
      781 ttttcaaaaa atattcgcct gtcggagaac ttgcggagtt tgcgtcacaa tacgcagatg
      841 tgcttgccaa aatcagctca atgccgacaa tcataacaga ccgtgaccat gtaatcgcag
      901 ccgcaggagt ttcaaagcgt gaatttcttg agcgcagggt aacagctgtg cttgagggat
      961 atatggaaaa ccgcaaaact tattcggcaa cacagcagac gctaggcgat attcagccga
     1021 ttgagggcat tgaacattat gcatcggtaa tctatccgat tatcgccgcc ggagatgttt
     1081 cgggtgcggt agttatgctc acaggcgaac agaccaaaat cccgtcaaat gccgaaatca
     1141 agcttgcaca aacagccgcc gcattcctcg gcaagcaaat ggaagaatga tttttaaaaa
     1201 taggtaataa taaaaaatgc ggtcgggaag acaggtgtaa aacaatacac cgaattttct
     1261 cgaccgtatt tgtataatta tgcatttact tgtagcagag aacacggttt gccactactg
     1321 ttttttataa agtttgaatt ttcaaaccat tatcacacca catcaacctg gcacattttc
     1381 attgttgcga gggcggaatt atgggtttcg ggggttacgc cggcacagca agccgaatca
     1441 acgctgattt cagcgttcgg gaaaagtgcc tttagaatca acgcatttga cacaacgcag
     1501 atatcggtgc aaagtccgac aagctcgatt ttttcaaagc agaatttatc ccaatgagta
     1561 tagccgaatg acggcttgtc aatatgaatt gcatcaggaa catcaagtcc gtctgcaatc
     1621 tgccagccgt gagtattttt tacacaatgc acaacgggca gttttttgcc ctcgggagtg
     1681 cttaggtaat cttcaccgtg agtatccctt gtaaaaataa tttcatcacc gtttgaacgg
     1741 tattcttcaa tctttttgcg tacattaggc acaattttca cagcctcggc agtgccaaga
     1801 ctgccgtcaa taaaatcgtt ctgcatatct attacaatca aagttttctt catacaaatc
     1861 actccgtttt tattttgaac tgtgacggct taacatacag cgtcttgtta ttgacataaa
     1921 tcaccatacc gggttttgaa ccgtttggct ttgatacata acgaacgagt gtgtagtcaa
     1981 cgggaacctg actgctgttt ctcgccttgc tgtgatacgc cgcaagctgt gccgcctcac
     2041 agattgccgt gtcggaaatc tttttgccgt ccgaaacaac aattacatgc gaaccgtgaa
     2101 tgtcctttgt gtgcagccac atatcgttct ttgacgctgt ttttaaagtc agcttatcgt
     2161 tctgacggtt gtttcttccg acaaggattt taaagccgtc acttgattca aattcgagcg
     2221 gcggcaaagt tgtctgacgg ggctttttgc ctttttgaac cttgagatag ccctgctcgg
     2281 taagttcctc acgaatttgt gcaatgtctt tttcattctc cgcacggtca accgtatcaa
     2341 gaacggagtc tatataatca agctcttctc tgcccttttc aagctgttct ttgagcataa
     2401 tttcggcatt tttagccttg cggtaatcct tgtaatactt ctgagcattt gccgaaggtg
     2461 agattgccgg attaagcttt atgcgtaaaa ttgcgttgtt ctcatcgtaa aagttttcaa
     2521 catcaacata ctccgcacca cgctcaatgc gatagatatt tgcctgtaaa aggtcaccgc
     2581 atatgcgaag atgctcacgg tctgcacagc gttcaagctc actcttctgc tttgcaatct
     2641 ttcgtgcaag cctttcaagg gtgttgttca aaagctttgt aaggctttgt gatttcaccc
     2701 tcattctgtc acggctgtca cgagcctcat agaatccgtc aagcaaatcg gagaagcttt
     2761 ccttactctc aacctttgca aaatcgccgt actgctcaac attcataaag cagaagtcca
     2821 taggcttgcc gtcctcacga taaaccacaa caggcttgcc cgaacaatcg ctgcaaatgc
     2881 ttttcagcct ttcgatttca accgcgagtc ggtcaaaaag cacaccctca attctgttgg
     2941 ttgcgccctc cataaccttg tattcaatct cacggcatac aatcggagaa gcaccctcaa
     3001 ttgtccttaa cagtgccttg ttaagcggca tttccgtgtc aagatttttt accgccgtac
     3061 acacatcaag tgcagtacat ttaagcagat tcagcttgtt ctgcgattcg ggaagttcgt
     3121 attttatatt cggcagtaca agtcttttac tgctcattgt aagatctaca cgcttgagtg
     3181 aatcgatgat gacgccgttt gaatcaacaa taattatgtt gctgtacata cccataattt
     3241 cgcatacaac agttatcatc acagtatcgc cgagttcgtt cacgcactcg aaatcgagca
     3301 taagaacacg gtcgcaaccg ttctggcgaa gtcccacaag ctttccgccg ccgattcttt
     3361 ttcgcaaaag catacagaac atcggaggtt gtgcaggatt ttcgggtgtt gaggaacaaa
     3421 agttcactct cggtgaattt gctcgtgcag aaagcaacag ctttttgttg ccggaaaatg
     3481 ttctcagacc gaacacaagc tcctctctgt tcggctgata aatctgcgac acccttgcac
     3541 cgagagcctc tttttctatt tcagttttaa tatgtcttaa aaaaattccg tcaagcgcca
     3601 tagtaactcc gtaaattatt tgtgatattt accgtttgat gaaatctcaa acgcacggta
     3661 aatctgttcg cttaaaatca ttcttgccat ttggtgagga aaggtcattc tgctcattga
     3721 aagacggaca tccgcccgtt ttttaaccga ttcatcaagc ccgtagctgc cgccgattat
     3781 gaaatcaacg gtgctttttc cgcttacgga cgcattgtca atcaaagttg aaagctcctc
     3841 gctcgacata ggctttccct caatacacat tgcaacaaca taatccgaag gcgaaatttt
     3901 ttgcatgatt cgttttccct cagagaaaat aacctcatca atctgcgacc tattcggtat
     3961 gttgctctta atgcgttctt ccgaaagctc aataatattg aatttacaaa atgcggtcaa
     4021 gcgttttgca tactctgcaa ttgcgtcggt aaaatatttt tccttgattt ttccgatgca
     4081 gattatgtta attttaatca tatttctctt gtttgtttaa ggttaaaaga tgatggcttt
     4141 tgttgtgctt acactcggag caacatcaag cgaataatcg cttttgtact tcattccgtt
     4201 tgatgtgagc aggtcaacgg atgttgacat tgcaagcgga acagtgttat tttcttcgct
     4261 gaggtgaccg agcataagtc ttaatgttcc cttttcaaca aggttgacaa gctcctttgc
     4321 gcacgcctca tttgaaaggt gtcccctgtt tgaaaggatt ctctgcttta gcggataagg
     4381 ataaattccg tttttgagca tattgatatc gtgatttgac tcaagcacaa caaagtcgct
     4441 ctgctctgcg gcagttctga catcgggcag cataacaccc atatcggttg ctataagtgc
     4501 ggattttccg tcgggagcag taacacgata acagcagctt tccgccgcat cgtggggtgt
     4561 gtcaattcgc tgaacacgca tattgccgat tacaacctcg tcagttataa catctgcatc
     4621 cgtgtttgga tcaagcttat tacctgccct caaagcattg agcgtaccaa gacttgaata
     4681 caccttaaag ccgtaacgct ttgcaagcac acgcaaggca ctgcaatggt ctgtgtgttc
     4741 gtgagttata aaaactgccc cgatactgct catatcaagt ccgtttgcaa gcatagcgtt
     4801 ttcaatctgc ttacatgaac ggcctgcgtc aatcaaaacg ccctcggttg ccgaacctat
     4861 gtaataactg ttgcccttac ttccgctgaa cagcggtact gctcttgcca aaacaatcaa
     4921 tccttatcat tagtctgcca aatatgataa cacaaatttt atgatttgta aattttatct
     4981 cacaaaaaag ccgttctcac aaagaaaacg gctttgattt ctaattaagt tttaatcagg
     5041 caccgagctc ctgctcgttg tctcctgtaa aatacacctt tttaatgtct gcaccaagtc
     5101 ctctgaactt ttcaacaaca tcctcataac cgcgttcaat aaactgtatg ttcgaaatct
     5161 cggttgtgcc gttaatttca agagcggcaa taatcatagc cgcacctgca cgaaggtcgg
     5221 ttgccttaac gggagccgca gtgagcggag ttccgccctc aatgattgca agtctgccct
     5281 caacggaaat ctgcgcgccc attctgataa gctcgctgac atactgatag cggttatccc
     5341 agacattctc gttgatgata cttgttccgg gaacgctcat aagcaatgcg gcaaactgcg
     5401 gctgacagtc tgtcggaaag ccgggatgag gcatagtctt gatgttacag cgctttagcg
     5461 gagcagatga cgcgtcaacc ttgagagcct catcatattc cgtaatctta acacccattt
     5521 cacgcagctt tgcgctgatt gattcaaggt gcttcggtgt aatgttcttt accgtaatac
     5581 atcctcttgt tgcggcggcg gcacacatat atgttcctgc ctcaatctgg tcgggaataa
     5641 tcgaataggt aacgccgtga agatactcaa cgccacggat tttgataaca tcagtacctg
     5701 cacctctgac atccgcaccc attgaattaa gaaagttcgc aaggtcaaca atatgcggtt
     5761 ctcttgcggc attttcaata atagtctgac cctttgcctt tgatgcggca agcataatgt
     5821 tcattgttgc accaacggac acaacatcaa ggtacacatg tgtaccgaca aggttgtcgc
     5881 attctgcctc tataatcgca ccgtcaacaa gctgagttgc cgcaccgaga gcctcaaagc
     5941 ccttgagatg ctggtcaatc ggacgcacgc caaagttaca gccgcccgga agagccacct
     6001 tagccctgcc gtacttgccc aaaagtgcgc caagaagata gtatgacgct ctcatacctc
     6061 ttacaaggtc tgtaaccgca ttgcatgtgc ggatttttgt aggatcaata tataaagacg
     6121 aacggttgat tcgccttaca ttagcaccca tctgctgaag aatcctgctg atgagcgata
     6181 catcgctgat gttaggaata ttttcaatct ggcagggttc atcacaaaga ataactgccg
     6241 gaataattgc aacggctgca tttttcgcac cgctgattgt cacttcacct gataatggct
     6301 ttccgccggt aactacaaac ttctccaatt gttacacccc aattatgtgc aaaagatatt
     6361 aaaaaaatat ctgaaatata tatcaaataa gtaaaactca aaaataacac gaatttaaaa
     6421 ttcgcagcag gaactaattt gttacatttt attaaaaata aacctgctcg attacgcaga
     6481 tgtaacctat caattctctt acagaaaatg atactacaaa actgtagtaa agtcaacgga
     6541 ataataaaac tgtaatctat ttttgggcag gttgtactca atttattgat ttcttgctgt
     6601 ttttgttttt attataacca agcgtcattt tttgaattga ttttccttaa aaagaagtaa
     6661 taactcaacg gctttttttg taagattgtt acaaattgaa acaagtgtta ttttcgtgtt
     6721 atcatcagga gtctgagcat tttacaattc aaattgaata cagaaaaata tcattctgcc
     6781 gcttcggaat aactttgcac ctttaattct tccttttctc ccttttattt taagcttctc
     6841 ttcctatact atattatata tactctccaa acgaacacaa taaacaagcg aaatattagg
     6901 gtaaaaaaac ttgaaaatta ttacactttt tcgtgtgtgt ctattgactt ttttaaatgg
     6961 gaatgctata ttataattaa catatgagca tatcttcata tgttcaagta taacttttaa
     7021 cctgagagaa aattaaaggg gacgcctatg gaaaacaaag aaaaaacaac cactcccgaa
     7081 atgcccgaca ttgatgtgct gtttgagctt gcagaccttt ttaaggtttt cggtgattca
     7141 acccgacttc gcattatgta caccatttcg gaaaatgaaa tgtcggtgct caacattgct
     7201 gaagctctca gcatggagca aagcacaatt tcccaccaac tgcgtgtgtt aaggcagaac
     7261 aagctggtgc gtgttcgccg tgaaggaaaa cagatttatt acagccttga cgatgaccat
     7321 gtgaaacgaa tcatcgaaat gggacttgac catgttcttg aataaggggg aacatatgag
     7381 gtataaatat cagcttgaca atctcaattg cgctcattgt gcaggcaaga ttgaggctaa
     7441 aattgcagaa acaaacggct ttgaggatgt gaacttcaat tttgcgacaa aacttctcaa
     7501 cttcaaaagc gaaaggcaga atcctgtttc cgaaattcag gcaatctgcg acagcattga
     7561 ggacggtgta actgttgttg acaaaactcc gaaaaccaat ctcaaaaaat acacctacac
     7621 tttagacaat ctcaattgtg ctcattgtgc gggcaaaatt gaggctaaaa ttgcagaaac
     7681 agacggcttt gaggatgtaa gcttcaattt tgcgacaaaa cttctcaact tcaaaagcga
     7741 aaagcagaat cctgtttccg aaattcaggc aatctgcgac agcattgagg acggtgtaac
     7801 tgttgttgac aaaactccga aaaatgatat cacaacaaag ccagaacccg aaatcacaaa
     7861 aaagaaaatc aaccgtgaca caatcttcct tgcaatttca attgtacttg ctgtagtgtc
     7921 cgaaattctc caccttacac ttgacggtgt tacggctgtt cattatgttg tactcgcagc
     7981 gtgttttgtt gcaacacttc tttcgggtta caaggtattt atcaagggtg caaaaaacat
     8041 tctaaagctg agaattgacg aaacaacgct tatgtctgtt gcggtaattg cggcattctg
     8101 tcttggagat tttgttgagg cggcaatggt aacaatcctc ttttctatcg gtgaaatttt
     8161 tgaggatcga gcagttgacg catcccgccg tgacattgaa aagcttgcaa acattcgtcc
     8221 cgatacagca acaattattg ttgacggtgc ggaacagatt gttcctgccg aaagcgttga
     8281 aatcggaagt atcattgaag tcaagccata cgaaagagtt ccgcttgacg gcattattat
     8341 taaaggtaaa acaactctcg acacatcggc tctcacaggc gaaagccttc ctgttgatgc
     8401 aggcgagggc agtgaggtac tcagcggcgc aatcaacggc agtaacctta ttactgtcaa
     8461 aaccacaaaa catttcggcg acagtaccgc aacaaggatt cttcagcttg ttgaagatgc
     8521 cgccgctcaa aagggcaaca gcgaaaagct tatttcaaaa tttgcctctg tttacacacc
     8581 ggttgttgta ctcattgcag ttgcaatcgc agtaatccct ccgctttgcg gactcggagc
     8641 attcagcgag tggctatacc gtgcgcttgt ttgtcttgta gcgtcatgtc cgtgtgctat
     8701 tgttatttcc gtacctctct cctactattc gggtatcggc gcggcatccg aagtcggtgt
     8761 actcatcaag ggcggaaaat atattgaggc tcttgcaaaa gcagacacat tcgtattcga
     8821 taaaacaggc acgctcacaa gcggcaagct cagcgtaaac aaggttaata ctgtcggttc
     8881 atacagtgct gacgaagttc ttgctcttgc cgctgcaagc gaaaaatatt ccgctcatcc
     8941 gattgcctcc gcaatcagag aaaaggcaaa cggtcttgaa cttcccgagc tttccgacta
     9001 cagcgaaagt gccggtcacg gaacaagcgc agtttataac ggcaaaacta ttcagtgcgg
     9061 cggttcaaag attctttcgg acgaggagaa gaagattgca aataaagacg attctgtttt
     9121 cgtaatttat gacggtcagc ttatcggttc gctcaatgtc agcgacacag taagacctga
     9181 ggcaaaagag gttatctcac agcttaaagc gctcggtgtc aagaacacgg taatgctcac
     9241 aggcgacaga caacagcctg ccgaaaatgt taaaaacgaa ctcggacttt ccgaatgtca
     9301 cgcagaactt ctccctgctc aaaagcttga acttttcaag ggcttgaaat caaaatccaa
     9361 gggtgcttgc tttgtgggtg acggtatcaa tgatgcccct gttctttcgg caagcgactg
     9421 cggtattgca atgggatttg gcagtgaggc agctattgaa gcgtcagacg cagttctcgc
     9481 atcaggcaca ctcaaacagc ttccaaaggc aattaaaatt gcaagaagtg ttatcaacac
     9541 tgtcaagggc aacatcatct tcgccctctc aatcaaggct cttgtaatta tccttgccgc
     9601 attcggtctt gcacaaatct ggatgtctgt tatcgccgac acaggcgtca gcgtggtctg
     9661 cgtcctcata gccgcaagac tcctcaaaaa gaaatattga ttttctcaac aatcattact
     9721 gttcccgagc aggtaaaact gttcgggaat tttcttgtta ttactcttat acagatactt
     9781 ttatggtcag cattttgctt ttgttgttaa tcatttatta tatctttttc aggcgatgac
     9841 agaataattt aaaatcctgc aaaaaattta atttatggtc aatactgctc tttacttttt
     9901 aaggtattta ttgtataatt agcggtaaag taaaaaggta tatttaatgt tacaaaacac
     9961 cttttgctca cagtaaaaag gataggaggg acaaaacata atgatcagcg gtgctgaaat
    10021 tatggtaaaa tgtttggaag ccgagggcgt tgatatagtc tttggttatc caggtgcggc
    10081 tatctgccca ttttacgata aaatttacga ttcgagcatt acccacattc ttgttcgtca
    10141 ggaacagaac gctgctcatg cggcaagcgg ctatgcaaga tgcagtaatc gtcccggtgt
    10201 ttgcgtggca acttccggtc ccggtgcaac caacctcatc acaggcattg caaccgccta
    10261 tacggactct attccgattg ttgccattac aggtcaggtt cgttccgacc ttctcggcag
    10321 agatgtcttt caggaagctg acatcacggg agcttgtgaa ccgtttgtaa agcacagtta
    10381 tctcgtcagc aaaacagaag accttccgag agttttcaaa gaggcgttcc atattgcctc
    10441 aaccggcaga cccggtcctg tacttatcga cattcccgtt gatattcagg aaaatgaaat
    10501 tgaaagtttt gaatatcccg aaagcgtaaa cattatcggt tacaagccga acactaaggg
    10561 acacgcaatt caggttaaaa aggctgttga ggccatcaac gcaagcaagc gtcctgttat
    10621 cgtatcaggc ggcggcgtgc tgagttcggg tatcaagctt aaacttcaaa aatttgcaga
    10681 aactacgggt atccccgtta tttcaactat gatgggcatc ggtgttatgc ccagcgagca
    10741 tgagctttat ctcggaatgc tcggcactca cggcaaggct gttgccaacc gtgctcttca
    10801 cgaagccgac cttgtaatcg tatgcggtgc aagactcggt gacagagctg ttgcggctcc
    10861 cgaccagatg agtgaaaaca caaaggtaat tcacattgac attgaccctg ctgaaatcgg
    10921 taagaatgtt aaaacagaaa ttccgattgt aggcgatatg aaaaatgtca tcaatatgct
    10981 gcttgacagc atcggcgatt acaaggttac aacaatgtgg agcgaaaccg taaagaactg
    11041 gaaaaaagac ctttaccgtg agcctcccgt atttgacggc tttgttgagc cgagaacact
    11101 tgtcggtcat ctcagcgcaa tgttccgctc aaaggcaatt cttgttgccg atgtaggaca
    11161 aaatcaaatc tggtgtgcaa acaacttccg tattcgtgag ggcagatttc tcacaacagg
    11221 cggtatgggt acaatgggtt actcaattcc cgctgcaatc ggtgcaaagt ttgcaagacc
    11281 cgaccgtgat gttattgtaa tctgcggtga cggcagtttt cagatggggc ttaatgagct
    11341 tgcgactatt gcaggcaatc agctcggaat taaaatcatc attatgaaaa acgcacgact
    11401 cggaatggtt cgtgaacttc aggacaaaca ctacggcggc agacactccg caacaattct
    11461 caacggtgat cccgacttct tgaagattgc cgatgcttac ggcattgacc atgcagaggc
    11521 tcattcaaac aaggaagccg aaaacatcat caagggtatt gttgattcgg aaaagccgtt
    11581 cattcttgtt tgcgatgttc accccgacac tccgtcaatt taatgaggtg ataaaatgca
    11641 gtatacatta tcaatacttg ttgaaaatca ggcgggcgtt ctttcaaaga tttcgggact
    11701 tttctctcgc cgaggtttta acatcgactc acttgcagta ggtgttactc aggaaccgtc
    11761 ggtttcccga atcacaatcg ttgcaaacgg tgacgagtac attgttgaac agcttgaaaa
    11821 gcagctaaac aagctcattc ccgtcatcaa ggtaaaaagg cttaacgagg gcgaatttat
    11881 cagccgtgag cttgttttaa tcaaggttca ctgcgccgcc tcaaaaagag ccgaaattgt
    11941 caaaacggtt gaaattatgc aggcgaaaat cgttgatgta tccccttcgt cagttaccgt
    12001 tgagtactgc gaatgtgcaa gccgcgtcaa cacgcttgtt gacttactca agccttatgg
    12061 tatccgtgag attgtaagaa caggtactgt tgccattgac agaggcacag cttcggtttc
    12121 cgtttaatct tacagttagc atatatttta atttatatgc cgcgtttgcg gtaaggagga
    12181 ctttaatatg aaagactaca caaaaaacat gacagcacca atctactatc agtcagattg
    12241 caaccttgac cttctcaagg gtaagaaaat tgctattatc ggttacggca gccagggtca
    12301 tgcacacgct ctcaacctca gggattcagg ttgcgatgta atcgtcggtc tttacaaagg
    12361 cagcaagagc tgggcaaagg ctgaggcaca gggctttaag gtatatacat cggcagaggc
    12421 tgcaaagcag gctgacatca ttatgattct tatcaacgat gaaaagcagg cagctcttta
    12481 caagaacgac atcgagccaa acctcgaagc aggcaatatg cttatgttcg ctcacggctt
    12541 taacattcac ttcggttgca tcaagcctcc aaaggatgtt gatgttacaa tggtagctcc
    12601 taagggaccg ggtcacacag ttcgttcaga gtatcaggtt ggtaagggtg taccttgcct
    12661 cgttgctgtt gagcaggatg ctacaggtca ggctaaggat ctcgcacttg catatgcact
    12721 cggtatcggc ggtgcaagag ccggcgttct tgaaacaaca ttcagaacag aaacagaaac
    12781 agacctcttc ggtgagcagg ctgttctttg cggcggtgtt tgcgcactta tgcaggcagg
    12841 ttttgaaaca ctttgcgatg ccggttacga cccaagaaac gcttactttg agtgtatcca
    12901 tgagatgaag ctcatcgttg accttatcta tcagtcaggt tttgcaggca tgagatattc
    12961 aatctctaac acagctgagt acggtgacta catcacaggt ccaaagatca tcacagagga
    13021 tactaagaag gctatgagaa aggttctttc tgacattcag gacggtacat ttgctaagga
    13081 cttcctcctt gacatgagcg atgccggttc acaggttcac ttcaaggcta tgagaaagat
    13141 cgctgccgaa gctcctgccg aagtattcgg taaggaagtt agaaagctct acagctggtc
    13201 tgacgaagat aagctcatca acaactaatg ttttttagtt cgtgaagtta gtttgatata
    13261 ttcaaacttc tgtcacccga gcattacata gtatgaatta acggttcagt caatttggct
    13321 gaaccgtttt tttgttgtgc aataaaaggg ttcagctttt tacggctgaa cccttttgca
    13381 gttaaaactt atcaattttt aaataatcaa tacttctcat aggagaaaga attataagcg
    13441 tcaagcaaag actgcttatt ctcggctgtt gtattctcac cccatacgct ggtatcacca
    13501 taacctattg caataaattc ggtaaacata tgtgcattca cgcaattatt aaactgttta
    13561 aggttaattt cgttatattt tgcccgtgaa atatttttgt cattaccgtc aaaatatcta
    13621 taataaatat tatttgattc ttcgactacg cctcttgacg aatacata
//
