LOCUS       c00068_gnlPro..        13613 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GDFJMIIP_68.
ACCESSION   c00068_gnlPro..
VERSION     c00068_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 15:31:17
            Original ID  :: gnl|Prokka|GDFJMIIP_68
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13613
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13613
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[34:5007]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      35..5007
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13613
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13613
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             35..1459
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_1"
                     /sec_met_domain="CT_Vparvula (E-value: 7.4e-138, bitscore:
                     450.1, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNSKMNARERIDYLFDDHSFVEVGGYVSARNTDYNLGAKKVEGD
                     GVITGYGVINDRMVYVYSQDASALGGSVGEMHAKKIASLYDLAMKTGAPVIGMLDCAGL
                     RLQEATDALHAFGTIFNKQAQASGMIPQISAVFGMCGGGSAVMSAMSDFTLMEKENGSL
                     FINSPNALAGNEESRQNTAGAQFQSEQAGNVDFVCETEEALLDQLRILVDVLPSDYEAE
                     DVYFDNDDDLNRVIPELNDAAYDAAYILKSISDNNMYIETKAAYAKEMVTAFIRLNGET
                     VGAVANQPVDGESVLTRNGLEKAERFIKFCDAFSIPLLTVTNVTGLRANAHEERKQALA
                     LAKFTTTLAQVSVPRINLIAGEAYGTAAEVMNSKAIGADFVLAWPQASVGMMDAEQAVR
                     IMYAEEINTDKNKTALIAEKTAEYAEGQSSALAAAKRGYIDDIIEPDATRKRLIAAYEM
                     LYGKKVTPVTKKHTAV"
     CDS             1472..1816
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_2"
                     /sec_met_domain="OAD_gamma (E-value: 6.8e-28, bitscore:
                     87.2, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVFEQALLNTLMGMGTVFAVLIFISLLISLFVYIPSIERALKNR
                     SSKKEKKAAQEERPAPKRPILEEVVEEEELVDDGELVAVITAAIMAANGGAAVSADKLV
                     VRSIKRVKRR"
     CDS             1911..2279
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 66.6; E-value:
                     4.3e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1e-21, bitscore:
                     66.6, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNYRITVNGVAYDVAVEELGAGEASAAPVSTPAAVPAPAKKVAP
                     KTSGSAGAVKITAPMPGKIVAVKAQAGASVKKGDAVLVLEAMKMENEICAAQDGVIASV
                     EVAVGDMVEGGDVLATMN"
     CDS             2313..3437
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_4"
                     /sec_met_domain="OAD_beta (E-value: 1.4e-157, bitscore:
                     514.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVVETMTNLAAQTGFAFLKPGNFIMILVALVFLYLAIAKGYEP
                     LLLVPISFGMLLVNLYPSIMEEGGLLHYFYLLDEWSILPSLIFLGVGALTDFGPLIANP
                     ASFLLGAAAQFGIYSAYFLAMLMGFNGKAAAAISIIGGADGPTSIFLAGKLGQTDLMGP
                     IAVAAYSYMSLVPIIQPPIMKLLTTEKERQIKMEQLRTVTKTEKIMFPIVVTVVVCLIL
                     PTTAPLVGMLMLGNLFRESGVVKQLSETASNALMYIVVIILGTSVGATTSAEAFLNVST
                     IKIVVLGLVAFAVGTAAGVLFGKLMCKVTGGKVNPLIGSAGVSAVPMAARVSQKVGAEA
                     DPSNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             3595..5007
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_5"
                     /sec_met_domain="HMGL-like (E-value: 1.7e-43, bitscore:
                     139.0, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 4.6e-59, bitscore:
                     189.5, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIKKKPVKIVETVLRDAHQSLIATRMTTEEMLPIVDKMDQVGY
                     HAVECWGGATFDACLRFLKEDPWERLRKLRDGFKNTKLQMLFRGQNILGYKPYPDDVVE
                     YFVQKSIANGIDVIRIFDCLNDLRNLQTAVDATKKEGGHAQIALSYTIGDAYTLDYWKK
                     TAKNIEEMGADSICIKDMAGLLVPNEATRLVTALKQATDIPIELHTHYTSGVGGMTYLK
                     AVEAGVDIIDTAMSPFAMGTSQPATEVMAETFRGTEFDTGFDQKLLGEIADYFRPIREK
                     YIANGLMSPKVLGVNIKTLMYQVPGGMLSNLVSQLEQQGASDKFYEVLEEVPKVRKDFG
                     EPPLVTPSSQIVGTQAVLNVLTGERYKMITNESKALLRGEYGQTVKPMNKEVQKKAIGD
                     EKPITCRPADLLEPELSKIEAEMSQWKEQDEDVLTYALFPQVATEFFKYRAAQENKIDP
                     AKADVKNGAYPV"
     CDS             complement(5263..5652)
                     /locus_tag="ctg68_6"
                     /transl_table=11
                     /translation="MKKLFYPAVFHIAEEGGYWVTFPDFPECLTQGENMQEAYDMAIDA
                     LGLILTDDINDHKELPEPSNITHVDDGVVVIIPYDYLEYNRKYHNKSIKKTLTIPEWLN
                     NEALRLNLNFSQILQDALLNKIQSR"
     CDS             complement(5698..5886)
                     /locus_tag="ctg68_7"
                     /transl_table=11
                     /translation="MPMKPKEMIRLLKKNGFIKISQNGSHVKMKNFKTGKQTTVPLHSK
                     DLKKRLEDAILKQAGLK"
     CDS             6111..6254
                     /locus_tag="ctg68_8"
                     /transl_table=11
                     /translation="MNNAVSYAMDSQVIFQMFFSIVCIAAAIGVSILVLRFMRKFIDFL
                     LQ"
     CDS             complement(6303..7331)
                     /locus_tag="ctg68_9"
                     /transl_table=11
                     /translation="MIPIQNIYYMLSYAFQTLQAENYKDLATENFHNTAELCAAILDKG
                     IGIQLKHGLRRDYVSKSESLSTLQGKLNISESIKTQTMLKKQMICTYDEFSTNIQFNQI
                     IKSTVLLLLKANITNSRKKSLRKLLLFFSDVNEIDLHFVNWNQQYNRSNQNYQMLIGMC
                     YLVYKGLLTTQNNGTTKLMDFFDGQRMCRLYEKFLLEYYRKEHPELTANASQIAWQLDD
                     TENQMLPRMQTDIMLSKNNNILIIDAKYYSHMTQQQYGIHTLHSNNLYQIFTYVKNKEF
                     ELRNYEHTVSGMLLYAQTDEDIIPNNTYHMSGNQISVLALDLNQDFSKISRTLDDIAKN
                     FL"
     CDS             complement(7328..9196)
                     /locus_tag="ctg68_10"
                     /transl_table=11
                     /translation="MREIFGSIAGGAAYKFGLFFHKKTQSWTCGSPAKPVKLTENEAIQ
                     KAEEIRNDLVAGAEIISSFGPLNSTADYEQLYKQLEHISGINTVWRMKYYQMLFPILFA
                     PFYGQDIQLDVLHFLNQTPSEIPFIRMGQIALFSKKCNIPGIVFGHIWGRSTNHNNKSN
                     DSETNTLSDKKHKLHYWMYTVFDDTSWMECQQKEIMVLGMDDIGDYSQYDSKESLRQEL
                     ISTYDNSTSRKNQALMAWNFANKLAINDVIFAKRSNTLVGKGIVTGDYIFDDSRQEYKN
                     IRTVKWLQIGEWEHPGKSVAKRLTDITPYTDYIEKLITIFTPDELDDVDTQPEVDYPEY
                     SSADFLSDVYMSEQDYETLVNVLKMKKNIILQGAPGVGKTFTAKRLAYSIIGAKNPDRV
                     QMIQFHQSYSYEDFIEGYRPTENGFTIKKGSFYKFCKLAEDDDENDYFFIIDEINRGNL
                     SKIFGELFMLIEKDKRGIELQLLYSDENFSVPPNVYIIGMMNTADRSLAMLDYALRRRF
                     SFFTMKPGFNTIGFQTYQDSLKSDAFKKLISCIKQLNSKIAADISLGEGFCIGHSYFCG
                     LTAKTATVRTLTSIIEYELIPLLKEYWFDEPEKIIDWSDRLRSTVK"
     CDS             9409..10557
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg68_11"
                     /sec_met_domain="Aminotran_5 (E-value: 2.7e-79, bitscore:
                     256.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEIYFDNGATTRALPQVREIMDEVLEKEYGNPSSMHMKGFDAEK
                     YVNHAKEIIAKSLKVDPKEIYFTSGGTEANNLALIGTAFANKRERKHIITSCIEHASVY
                     NPLSFLEDEGFEVTYLPVDEHGIVDLEVLKKALRKDTLMVSIMCVNNEIGAIEPVEEIG
                     KIVKSFDPKILFHTDCIQAYGKLNCYPKKWKADMISVSGHKIHGPKGIGFIYIKNGTKI
                     KPIIWGGNQQKGMRSGTENVPGIAGLGKAAELIYENHEEKIAHIREIKDHFIKRVMEEI
                     PDVKDNSGDAPHVASISFLGVRSEVLLHALEEREIYVSAGSACSSNKPEVSGTLKGIGL
                     TKEYYESTLRFSFSIFNTVEEVDICVEALKELLPMLRRFTRR"
     CDS             10654..11838
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:Thiamine biosynthesis protein (Score: 226.6;
                     E-value: 6.8e-70)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg68_12"
                     /sec_met_domain="ThiI (E-value: 1.6e-70, bitscore: 226.6,
                     seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFKAFLIKYAEIGIKGNNRRFFEDALVRQMKYALKPVGDFSIRK
                     ESGRIFVHANEEYDFDEAVESLSHVFGIAGICPIVVEEDKDFEKIAEVVEKYVDEDYAD
                     KHFSFKVHVRRADKKYPIPSMEAAARLGERLLEKFEDLSVDVHNPDVMLTVEIRDKVYI
                     YSREIPGPGGMPVGTNGRAMLLLSGGIDSPVAGYMISKRGVSIDATYFHAPPYTSERAK
                     QKVVDLAKEIAKYTGPITLHVVNFTDIQMAIYEKCPHDELTIIMRRYMMKIAEHFANQD
                     NCLSLVTGESIGQVASQTMHSLYVTNEVCQMPVFRPCIGLDKNEIVKVAEKIGTYETSI
                     LPYEDCCTIFVAKHPVTKPRLDVIKRSERNLDDCIDELMKTAIETTEEIKINAH"
     CDS             11846..12040
                     /locus_tag="ctg68_13"
                     /transl_table=11
                     /translation="MDESIFKADISILIMFIMLADKCLFKRWEEEISLKIFVLSEDSYK
                     KNLSVKKEPRKVIFPRLIS"
     CDS             complement(12098..12334)
                     /locus_tag="ctg68_14"
                     /transl_table=11
                     /translation="MKTIKISLNSIDKVKTFVNVINRFDAEFDLVSGRYVIDAKSIMGI
                     FSLDISKPIDLNIHNADNLDEIMEQLQPYLVTE"
     CDS             12567..13613
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg68_15"
                     /sec_met_domain="Radical_SAM (E-value: 2e-30, bitscore:
                     96.3, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKRRAAFLTLGCKVNQYETDAMEEILEKAGYEIVSFKETADVYI
                     INTCSVTNMADRKSRQMIHRAKKNNPDAIIVAAGCYVQAAEEELAKKNEADILVGNNKK
                     KDIAQILEEYFAAKEPEQEVPVVSEVIDINHTKEYEDLTIHKVNEHTRAYIKIQDGCNQ
                     FCSYCIIPYTRGRIRSKNPEEVIEEVKNLAAQGYKEIVLTGIHLSSYGKDLGTVTLLDV
                     IKRIQQIEDVERIRLGSLEPRIITEEFVKELVKCDKVCPHFHLSLQSGCDETLKRMNRK
                     YTTEEYEEALNILRKYYEHPALTTDVIAGFVGETEEEFEKTRAYLEKINLYEMHIVKYS
                     VREGPRAQK"
ORIGIN
        1 gtatacaata tagcattttt atggaggaaa gaatatgggt aattcaaaaa tgaatgccag
       61 agagcgcatt gattatctgt ttgatgacca cagttttgtg gaagttggtg gatatgtttc
      121 cgctcgtaat accgattata atctcggtgc aaagaaagta gaaggtgatg gtgttatcac
      181 tggatacgga gttattaatg accgcatggt ttatgtttac agtcaggatg cttccgcact
      241 tggaggttcc gtaggtgaga tgcatgcgaa gaaaattgct tccctttatg atctggcgat
      301 gaaaacaggc gcgccagtca ttggaatgct ggattgtgca ggacttagat tacaggaagc
      361 gacagatgcc cttcacgcat ttggaacgat ttttaataag caggcacagg catctggaat
      421 gattccacag atttctgcag tatttggaat gtgtggagga ggaagtgccg taatgtccgc
      481 tatgtctgat tttacattga tggagaagga gaacggcagt ctctttatca acagtccgaa
      541 tgcattagcg gggaatgaag aatcccgtca gaatacggca ggagcacagt tccagtctga
      601 gcaggctggt aacgtagatt ttgtatgtga gacagaagaa gcacttcttg accagcttcg
      661 tattctcgtt gatgtacttc cttctgatta tgaagcagaa gatgtttact ttgataacga
      721 tgatgattta aatagggtta ttcctgagtt aaatgatgcc gcatatgatg ccgcttacat
      781 tttaaaatct atttctgaca acaatatgta catagagaca aaggcagcct atgccaaaga
      841 gatggtaact gcatttatcc gtctgaatgg agagacagta ggtgcggttg caaaccagcc
      901 agtagatggt gagtccgttt taacaagaaa tggtcttgaa aaagcagaaa gatttattaa
      961 gttctgtgat gcattttcga ttcctcttct tactgtaacg aacgtgacag gacttcgtgc
     1021 caacgcacat gaagagagaa agcaggcgct cgcattagcg aagtttacga caacacttgc
     1081 acaggttagt gtacctcgta ttaatctcat tgcaggcgag gcttatggaa ctgcagcgga
     1141 agtaatgaat tctaaagcta tcggagctga ctttgttctg gcatggccac aggcatctgt
     1201 aggaatgatg gatgcagaac aggcagttcg tatcatgtat gcagaggaaa tcaatacaga
     1261 taagaataag acagcactta tcgcagagaa aactgcggaa tatgcagaag gacagagcag
     1321 tgcattagca gctgcaaaga gaggatatat agatgacatc atcgagccgg acgcaacaag
     1381 aaagcgtctt atcgctgctt atgaaatgct ttacggaaag aaagtaactc cagtgacaaa
     1441 gaagcatacg gcagtatagt gaggtgagag tatgaacgta tttgaacaag ccttattaaa
     1501 tactttgatg ggtatgggaa ctgtatttgc agtactgatt ttcatttctt tactgatttc
     1561 tctttttgta tatatcccat ctattgaaag agcgttaaag aatcgttctt ctaagaaaga
     1621 gaaaaaggct gcgcaggaag aaagaccggc tccaaagcgt ccgattcttg aagaagttgt
     1681 ggaagaagag gaacttgtgg atgatggtga acttgtcgca gtaatcacag cggcaatcat
     1741 ggcagcgaat ggaggagcag cagtcagtgc agataagttg gtcgttcgtt caatcaagag
     1801 agtgaagaga agatagcaaa aatgtattct tggaatcttt ttataaagtt ttgaaaagtt
     1861 agttatagaa agattttaga agtacataaa atcattcagg aggatttaca atgaaaaatt
     1921 atagaattac agttaatggt gttgcttatg atgtagcagt agaagaatta ggtgcaggag
     1981 aagcaagtgc agcgccggta agtacaccag cagccgttcc ggctccagct aagaaagttg
     2041 ccccaaagac ttccggaagt gccggtgccg taaagattac agcaccaatg ccaggtaaga
     2101 tcgtagcagt aaaggcacag gcaggtgctt ctgtaaagaa gggcgacgct gttcttgtat
     2161 tagaggctat gaagatggag aatgaaatct gtgcagcaca ggatggtgtt atcgcaagtg
     2221 tggaagtagc agttggagat atggtagaag gcggagatgt actggctaca atgaactaga
     2281 gcatatttgc aaaataaaac ggaggaagat ttatgagtta tgttgtagag acaatgacga
     2341 atctcgcagc acagaccgga tttgcattct taaagccagg taacttcatt atgatactgg
     2401 ttgctttagt cttcttatat ctggccatcg ccaaaggata tgagccactt ttgttagtgc
     2461 cgatttcttt tggtatgctg ctggttaact tatatccgtc cattatggaa gaaggcggat
     2521 tattacatta tttttactta ttagatgaat ggagtattct cccttcactg attttcttag
     2581 gtgttggagc actaacagac ttcggtccgc tgattgccaa tccagcaagt ttcttgctgg
     2641 gagctgcggc gcagtttggt atttacagtg cgtatttcct tgcaatgctt atgggattta
     2701 acggaaaggc agcagcagca atttccatta ttggtggagc cgatggtcct acttctattt
     2761 tccttgccgg aaagcttggg cagacagact taatgggacc aattgcggta gcggcatatt
     2821 cttatatgtc acttgtacca attattcagc caccgatcat gaagctcctt actacagaaa
     2881 aggaacgtca gattaagatg gaacagttaa gaaccgttac aaaaacagag aaaattatgt
     2941 ttccgattgt cgtaacagtt gttgtatgtt tgattcttcc tacaacagcg ccattagttg
     3001 gtatgctgat gctcggtaac ctttttagag agtccggcgt agtaaaacag ctttcagaga
     3061 cagcgtctaa cgctcttatg tacatcgtag ttattattct tggtacatcc gttggtgcga
     3121 caacaagtgc agaggcattc ttaaatgtca gcacaatcaa gattgtagta ttaggtcttg
     3181 tagcttttgc tgttggtact gcagcaggtg tcctgtttgg taaacttatg tgtaaggtta
     3241 caggtggtaa ggtaaatcca ttaattggtt ctgccggggt atctgccgtt cctatggcag
     3301 cccgtgtatc ccagaaagtt ggtgcggaag cagatccatc aaacttctta ctgatgcatg
     3361 cgatgggacc aaatgttgcc ggagttatcg gtacagcggt agccgccgga acatttatgg
     3421 caatttttgg agtataattt agaattattt gattatttaa aattcattat ttatagggct
     3481 ataatctgta aaaaatgtta caggggatat ttataaatag tttacaagtt gaattttaga
     3541 taataacagt tgtaagcgca aatagttacg tgatttgaaa taaaaggaga tattatggcc
     3601 gaaattaaga aaaaaccggt taaaatagta gaaaccgttc tccgtgacgc acatcagtct
     3661 ctgattgcta caagaatgac aacagaggag atgctgccaa tcgtagataa gatggatcag
     3721 gttggttatc atgcagtaga atgctgggga ggtgcaacat ttgatgcctg cctgcgtttc
     3781 ttaaaggaag acccatggga gagacttcgt aaattaagag atggctttaa gaatacaaag
     3841 ttacagatgt tattccgtgg acagaacatc ttaggatata agccatatcc agacgatgtt
     3901 gtagaatatt tcgtacagaa atctattgca aacggaattg atgttattcg gatttttgac
     3961 tgtttaaatg accttagaaa cttacagact gctgtagatg caacaaagaa agagggagga
     4021 cacgcgcaga tcgccctctc ctatacaatc ggtgatgcat atacattaga ctactggaaa
     4081 aagactgcta agaatattga agagatggga gcagattcta tctgtatcaa agatatggca
     4141 ggacttttag tgccgaatga agcaacgcgt cttgtaactg cattaaagca ggcaacagac
     4201 attcctatcg agcttcatac acactataca agtggtgtcg gcggaatgac ttatttaaag
     4261 gcagtagagg caggagtaga tattatcgat acagccatgt ctccatttgc aatgggaaca
     4321 agccagccgg caacagaagt tatggcggag acattccgtg gtacagaatt tgacacagga
     4381 tttgaccaga agcttttagg tgaaatcgca gattacttcc gtccgatccg tgagaaatac
     4441 attgcaaatg gcttaatgag tccaaaggta cttggtgtaa acatcaagac tttaatgtat
     4501 caggttccag gtggaatgct ttctaacctt gtatctcagt tagagcagca gggagcatcc
     4561 gataagttct atgaagtatt agaggaagtt ccaaaagtac gtaaagactt cggtgagcca
     4621 ccattagtta caccatctag ccagattgtc ggaacacagg ctgtattaaa tgtacttacc
     4681 ggagagcgtt ataaaatgat tacaaacgag tcaaaagccc ttcttcgtgg agaatacggt
     4741 cagaccgtaa aaccaatgaa taaagaagta cagaaaaagg caatcggcga tgaaaagcca
     4801 attacctgtc gtccagccga ccttcttgaa ccggaattat ctaagatcga ggcagagatg
     4861 agccagtgga aagaacagga cgaagatgtg cttacatacg cattgttccc acaggtagca
     4921 accgaattct ttaaatacag agcggcacag gagaataaga ttgatcctgc aaaagccgat
     4981 gtaaagaatg gagcatatcc ggtgtaggat tgatttagat taaaaacaga cgaacccccg
     5041 caactttata gatagcacat gtgaagattt cgctgcgtag aaaatgctca gccgcatttt
     5101 tacttgctcc gacatcacat ttgctatcta taaagttgtg ggggttctgt tttttaacct
     5161 aaacttgccg gaaatggata ggtgaagcta tcgtattagc tgccttgtta agtatattat
     5221 aatctatgat tgcagtatta ccaaatgaaa gaattatagc cattaacgag attgaatttt
     5281 gtttaaaaga gcatcctgca aaatctgtga aaagtttaaa ttcaatcgca atgcttcgtt
     5341 attcaaccat tcagggattg ttaaagtttt tttgatagat ttattatgat actttcgatt
     5401 atattccaaa taatcatatg ggatgattac gacaactcca tcatcaacat gtgtgatgtt
     5461 agacggttct ggaagttctt tatggtcgtt aatgtcatca gttaagataa gtcctaaagc
     5521 atctatagcc atatcatagg cttcttgcat attttctccc tgagttagac attcgggaaa
     5581 gtcaggaaaa gtcacccaat aaccgccttc ttctgcaata tgaaatacag caggataaaa
     5641 taattttttc ataatggata cctccaatgt atgtgagtta ttatagatga aataaggcta
     5701 ttttaagccc gcttgtttta ggatggcatc ttctagtctt ttttttaaat ctttgctatg
     5761 aagaggaact gttgtttgtt tgccagtttt aaaattcttc attttcacat gggaaccatt
     5821 ttgacttatt tttatgaaac cattcttttt taataatctt atcatttctt ttggtttcat
     5881 tggcatagta tgccacccct ttctataatt atattataat acgtataata tacgtgtgtc
     5941 aagaactcgg tgatacaact ggtgaggaat agtatatcat atttaagaag aaaaacaact
     6001 aataaatgta aaataacata aaaaatgtaa ttttgaaaat gaaaaatttt tgataaaaat
     6061 acagagatat ggtaaaatga agtatcaaag gatagtcagg gggagataca atgaataacg
     6121 cagtttcata tgctatggat agtcaggtga tttttcagat gtttttttca attgtatgta
     6181 tagcggcagc tataggtgta tccattttgg tccttcgctt tatgaggaag tttatagatt
     6241 ttttgttaca ataggggtaa tagaagtaag gaagggatat taggtccctt cctttaaaaa
     6301 ttttaaagaa aatttttggc gatgtcatct aaagttctgg agatttttga aaaatcctgg
     6361 tttaaatcta atgcaagaac agaaatctga tttccgctca tatggtaggt gttattagga
     6421 ataatatctt catcggtttg tgcataaaga agcattcctg atacagtatg ttcatagttt
     6481 ctcaattcaa attccttatt ttttacatag gtaaaaatct gataaagatt attggaatgc
     6541 agagtatgta ttccgtattg ttgctgggtc atatgcgaat aatatttggc atcaataata
     6601 agtatgttat tgtttttgga taacataata tctgtctgca tcctaggaag catttgattt
     6661 tcagtatcat caagctgcca tgcaatttgt gatgcattgg cggtgagttc tggatgttct
     6721 ttccgataat attcaagcaa gaatttttca tataagcgac acattcgttg tccgtcaaaa
     6781 aaatccatga gtttagtagt gccgttattt tgtgttgtca gaagaccctt atagactaga
     6841 tagcacatac cgattaacat ttgatagttt tgattagagc gattatactg ttgattccaa
     6901 tttacaaaat gcaggtcaat ttcattaacg tcagaaaaaa atagcaatag ttttcttaga
     6961 ctcttttttc ggctgtttgt aatattcgct ttaagaagca gtaatacagt ggatttaata
     7021 atttggttaa attgtatatt ggttgagaat tcatcatagg tacaaatcat ttgttttttg
     7081 agcattgtct gggtcttgat ggattctgaa atgttaagtt ttccctgtag tgtagaaaga
     7141 gattcggatt ttgatacata atctcttctt aaaccatgtt ttaattgaat accaattcct
     7201 ttatcaagaa tcgctgcaca taattctgca gtattatgaa agttttctgt tgctaagtct
     7261 ttgtaattct ctgcctgtaa tgtttgaaaa gcataggaca gcatatagta aatattttga
     7321 atgggaatca tttgacggta ctccttaatc tatcagacca gtcgatgatt ttttcaggtt
     7381 catcaaacca atattctttt aaaagaggaa tcaattcata ttctataatg gatgtaagtg
     7441 ttcggacagt agctgttttg gcagttagtc cacaaaaata gctatgcccg atacaaaatc
     7501 cttctccaag agaaatatct gctgctattt ttgaatttaa ttgttttatg caagaaatca
     7561 attttttaaa agcgtcactt tttaaagaat cttggtaagt ctgaaaacca atagtattaa
     7621 atcccggttt catagtaaaa aatgaaaaac gtcgtcttaa agcataatct aacatggcaa
     7681 ggctacgatc agcagtattc atcatgccga taatatatac attgggtggt acagaaaaat
     7741 tctcatcaga atataataac tggagttcaa taccacgttt gtctttttca atcaacataa
     7801 ataattcacc gaatatttta cttaaattac cgcgattgat ttcatcaata ataaagaaat
     7861 aatcattttc atcgtcatcc tcagcaagtt tgcagaattt gtaaaaagac ccctttttga
     7921 ttgtaaaccc attttctgtc ggacgatatc cctcaataaa atcttcatag gaatagctct
     7981 ggtggaactg aatcatttga acacggtcag gattttttgc accaataata gaataggcaa
     8041 gacgtttggc agtaaatgtt tttccaacac caggtgcacc ctgtaaaatg atatttttct
     8101 tcatttttaa gacatttacc aatgtttcat aatcttgctc actcatatat acatcggaaa
     8161 gaaaatcagc agaagaatat tctggatagt ctacttcagg ttgtgtatct acatcatcca
     8221 attcatcagg agtaaagata gtaataagtt tttcgatata gtcggtatat ggggtaatat
     8281 cagttaagcg tttggcaaca gacttaccgg gatgttccca ttcgccaatt tgaagccact
     8341 ttacggtacg gatattttta tattcctggc gagaatcatc aaaaatataa tctccggtga
     8401 caataccttt accaacaaga gtattacttc gctttgcaaa aatgacatca ttgatcgcca
     8461 gcttgtttgc aaaattccat gccattaaag cctgattctt tcgagaggta ctgttgtcat
     8521 aagtgcttat caattcctga cgaagagatt ccttagaatc atattgagaa taatctccta
     8581 tgtcatccat gccgagaacc ataatttctt tttgctggca ttccatccaa ctggtatcgt
     8641 caaagaccgt gtacatccag tagtgaagtt tatgtttttt gtcggaaagc gtattagttt
     8701 cagaatcatt agatttatta ttgtgattag tggatcttcc ccaaatatga ccaaaaacaa
     8761 taccaggaat attacatttt tttgaaaaca gtgcgatttg tcccatgcgt ataaaaggaa
     8821 tctcgcttgg tgtttgattt agaaaatgta atacatccaa ttgtatatct tgtccataaa
     8881 atggtgcaaa caatattgga aataacattt gataatattt cattcgccat actgtattaa
     8941 ttccagaaat atgttccagt tgtttgtaga gttgttcata atctgctgtg gaatttaaag
     9001 gaccaaagga agatattatt tcagcacctg ctaccaaatc attacgtatt tcttctgcct
     9061 tttggattgc ctcattttca gtaagcttta caggttttgc aggtgagcca caagtccagc
     9121 tttgtgtttt tttgtgaaag aaaagtccaa atttataagc tgctccaccg gcaatacttc
     9181 caaatatttc gcgcatatct ttgtccattt caagtacata acaaagattc aatttatttc
     9241 ctttttcatt ttcgcctgtt tatccgcaaa atccatttta cttctctctc attttatgtt
     9301 atgtttatat acgattatgc cattttttat ggctgttttt tgagtgtaga gaatggaaca
     9361 aaaaaacaat aagacataat atattttttg aaggagttgt aaacgagaat gtcagagatt
     9421 tattttgaca atggcgcgac cacaagggcg ctgccgcagg tgcgtgagat tatggatgaa
     9481 gtacttgaga aggagtacgg caatccatct tctatgcata tgaaaggatt tgatgcagag
     9541 aagtatgtca atcatgcgaa agagattatt gcaaagagcc tgaaagttga tccaaaggag
     9601 atttatttta cttctggtgg tacagaggcg aataatcttg cattgatcgg tactgcattt
     9661 gcaaataaaa gagagagaaa gcacattatt acaagctgta ttgaacatgc ttctgtatat
     9721 aatccattat cttttttaga agatgaggga tttgaagtga cctatcttcc tgtcgatgaa
     9781 catggaatcg tagatttaga ggtattaaag aaggcgcttc gtaaagatac attgatggtt
     9841 tctattatgt gcgtgaataa tgagattggt gccatcgaac cggttgagga gattggaaag
     9901 attgtaaagt cttttgatcc aaagatttta ttccataccg attgtattca ggcatatggt
     9961 aagttgaatt gttaccctaa gaaatggaaa gcagatatga tttctgtaag tgggcataag
    10021 attcacggcc caaagggaat cggatttatt tatattaaga atggaacaaa gataaagcca
    10081 atcatctggg gtggaaatca acagaaggga atgcgttccg gaacagaaaa tgtaccggga
    10141 attgcagggc ttggtaaggc ggcagagttg atttatgaga atcatgagga aaagatcgca
    10201 catatcagag agataaaaga tcattttata aaaagagtga tggaagagat tccagatgtg
    10261 aaggataatt ccggagatgc tccgcatgtg gcgagtatca gctttttagg agtaagaagt
    10321 gaagtgcttc ttcacgcatt agaagaacgt gagatttatg tatcagcagg ttctgcctgt
    10381 tcatctaata aaccggaagt cagcggtact ttgaagggca ttggtcttac aaaggaatac
    10441 tatgaatcga cgcttcgttt ttcattctct atttttaata cggtagaaga agtagatatt
    10501 tgtgtggaag cgttaaaaga actgttgccg atgcttcgga gatttacaag acgataaaac
    10561 aattagaaca taatgtactc tcggaatctt tttgagcttg attttgtgac aagaaagact
    10621 acgagagtac atcatataaa aaaggagata tttatggaat tcaaagcatt tttgattaaa
    10681 tatgcagaaa ttggaatcaa gggaaataat cgccgtttct ttgaagatgc ccttgtccgt
    10741 cagatgaaat atgcattaaa accagtagga gacttttcta tcagaaagga atctggacgt
    10801 atttttgtac atgccaatga agagtatgat tttgatgagg cggtggaaag cttaagccat
    10861 gtattcggta ttgcaggtat ttgtccaatt gtagtagaag aagataaaga ttttgaaaag
    10921 attgcggaag tcgtagaaaa atatgtagat gaagattatg cagataagca tttttctttc
    10981 aaagtacatg taagaagagc agacaagaag tatccaattc cgtctatgga agcagctgcc
    11041 cgtcttggag agagattatt agagaagttt gaggacttaa gtgttgacgt gcataatcca
    11101 gatgttatgc ttacagtcga gattcgtgat aaggtttaca tttattccag agagattccg
    11161 ggaccgggtg gaatgccggt tggtacaaac ggaagagcaa tgcttcttct ttccggtggt
    11221 atcgacagcc cggtagctgg ttacatgatt tccaagcggg gtgtaagcat tgacgcaact
    11281 tacttccatg cacctcctta tacaagtgag agagcgaaac agaaagtagt agatcttgca
    11341 aaagagattg caaaatatac aggacctatt acattacatg ttgtaaactt tacagatatt
    11401 cagatggcaa tttatgagaa atgtcctcat gatgaattga caatcattat gcgtcgttac
    11461 atgatgaaga ttgcagagca tttcgcaaat caggataact gtctttccct tgttacaggt
    11521 gagagtatcg gacaggttgc cagtcagaca atgcacagtc tttatgtaac aaatgaagtg
    11581 tgccagatgc cagtattccg tccttgtatc ggacttgata aaaatgaaat cgtaaaagtt
    11641 gcagaaaaga ttggaacata tgagacatct attttaccat acgaagactg ctgtactatt
    11701 tttgtggcaa aacatccggt aacaaagcca agattagatg taattaagcg ttctgagaga
    11761 aatcttgatg attgtattga cgagctgatg aagacagcga ttgaaacaac agaagaaatt
    11821 aagattaacg ctcactaaag tattaatgga tgaaagcatt ttcaaggcag acataagtat
    11881 tttgataatg tttataatgc ttgcagataa gtgccttttt aaaaggtggg aagaagaaat
    11941 atcactaaaa atatttgttt tatctgaaga ttcatataag aaaaatttat ctgtaaagaa
    12001 agaaccgagg aaagtaatat ttcctcggtt gatttcataa atacatcaca ggttatatat
    12061 aatatatccg tataccagaa aacccgctct tatgtaatta ttcagttact aagtatggct
    12121 gtaactgttc cataatctca tcaagattat cagcgttatg gatatttaaa tcgataggtt
    12181 tagaaatatc taaactgaaa attcccatga tagactttgc atcaataacg taacgaccgg
    12241 aaactaaatc gaattctgca tcgaaacgat tgatgacatt aacaaatgtt tttaccttat
    12301 cgatggaatt taaagagatt ttaatcgttt tcatatacgc gctcctccta aaaatgtcta
    12361 tatatatttt aataatatag taccttttta gtgaaaaaaa gtcaatagat ttgaggaaga
    12421 tttggaaaat attatctaaa gataaagggg aattttttgg catgaatctg gagatgaatg
    12481 aagttagaaa aaataggatt gcaggtagga aataataaat aacagaaaaa acgaaaagga
    12541 gaaacggaaa aaggagattt gtttttatga gtaaaagaag agcggcgttc cttacactgg
    12601 gctgtaaagt aaatcagtat gagactgatg ccatggagga gattcttgaa aaggcaggat
    12661 acgagattgt cagttttaaa gagacagcgg atgtctatat tataaatacc tgttctgtaa
    12721 caaatatggc agacagaaag agccgtcaga tgattcatcg tgcaaagaaa aacaatccgg
    12781 atgcaattat cgtggcagcg gggtgttatg tgcaggcagc agaggaagaa ctggcaaaga
    12841 aaaatgaggc ggatattctt gtaggtaata ataaaaagaa agatatcgct cagattcttg
    12901 aggaatattt tgcggcaaaa gaaccagagc aggaggtacc agttgtctca gaagtaattg
    12961 atattaatca cacaaaagaa tatgaagatt taacaattca taaggtaaac gagcatacaa
    13021 gagcatatat taaaatacag gatggctgta atcagttctg ttcatattgt atcattcctt
    13081 acacaagagg aagaatccgc agtaaaaatc cagaggaagt cattgaagaa gtaaaaaatc
    13141 tggcagcaca gggttataaa gaaatcgtgc ttaccggaat tcatttaagt tcctatggga
    13201 aagatttagg aacagtgact cttcttgatg tgattaagag aatacagcag atagaggatg
    13261 tggagagaat ccgtcttggt tctttagagc ctagaattat cacagaggag tttgtaaaag
    13321 aacttgtgaa atgtgataaa gtatgtccac attttcatct ttctttacag agcggctgcg
    13381 acgagacatt aaagcgtatg aaccgcaaat atacaacaga agaatatgag gaagcattaa
    13441 atattttaag aaagtactat gagcatccgg cattaacaac tgatgttatt gcaggttttg
    13501 ttggagaaac tgaggaagaa tttgaaaaaa caagagcata tcttgagaaa atcaatctat
    13561 atgagatgca tattgttaag tattctgtac gagaaggacc aagagcacag aag
//
