GCA_958347485.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaPKFBICOC_1 (original name was: gnl|Prokka|PKFBICOC_1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	ranthipeptide	245,187	266,794

gnlProkkaPKFBICOC_4 (original name was: gnl|Prokka|PKFBICOC_4)

Region	Type	From	To	Most similar known cluster		Similarity
Region 4.1	NRPS-like,cyclic-lactone-autoinducer	15,346	57,064

gnlProkkaPKFBICOC_7 (original name was: gnl|Prokka|PKFBICOC_7)

Region	Type	From	To	Most similar known cluster		Similarity
Region 7.1	NRPS,HR-T2PKS	62,898	149,260	leucomycin	Polyketide	3%

gnlProkkaPKFBICOC_9 (original name was: gnl|Prokka|PKFBICOC_9)

Region	Type	From	To	Most similar known cluster		Similarity
Region 9.1	RRE-containing	63,004	83,267

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	ranthipeptide	245,187	266,794
Region 4.1	NRPS-like,cyclic-lactone-autoinducer	15,346	57,064
Region 7.1	NRPS,HR-T2PKS	62,898	149,260	leucomycin	Polyketide	3%
Region 9.1	RRE-containing	63,004	83,267

No secondary metabolite regions were found in these records:: gnlProkkaPKFBICOC_2 (original name was: gnl|Prokka|PKFBICOC_2); gnlProkkaPKFBICOC_3 (original name was: gnl|Prokka|PKFBICOC_3); gnlProkkaPKFBICOC_5 (original name was: gnl|Prokka|PKFBICOC_5); gnlProkkaPKFBICOC_6 (original name was: gnl|Prokka|PKFBICOC_6); gnlProkkaPKFBICOC_8 (original name was: gnl|Prokka|PKFBICOC_8); gnlProkkaPKFBICOC_10 (original name was: gnl|Prokka|PKFBICOC_10); gnlProkkaPKFBICOC_11 (original name was: gnl|Prokka|PKFBICOC_11); gnlProkkaPKFBICOC_12 (original name was: gnl|Prokka|PKFBICOC_12); gnlProkkaPKFBICOC_13 (original name was: gnl|Prokka|PKFBICOC_13); gnlProkkaPKFBICOC_14 (original name was: gnl|Prokka|PKFBICOC_14); gnlProkkaPKFBICOC_15 (original name was: gnl|Prokka|PKFBICOC_15); gnlProkkaPKFBICOC_16 (original name was: gnl|Prokka|PKFBICOC_16); gnlProkkaPKFBICOC_17 (original name was: gnl|Prokka|PKFBICOC_17)

Compact view

gnlProkkaPKFBICOC_1 - Region 1 - ranthipeptide

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Location: 245,187 - 266,794 nt. (total: 21,608 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaPKFBICOC_4 - Region 1 - NRPS-like,cyclic-lactone-autoinducer

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Location: 15,346 - 57,064 nt. (total: 41,719 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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core biosynthetic genes

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Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

No matches found.

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 15345 - 57064:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg4_40

AMP-binding (19..357): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: AAGCASVPRK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

ctg4_43

Search NORINE for peptide: strict or relaxed

AMP-binding (25..385): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQMGMIWK
Nearest Stachelhaus code(s):: Gly DILQMGMVWK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

gnlProkkaPKFBICOC_7 - Region 1 - HR-T2PKS,NRPS

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Location: 62,898 - 149,260 nt. (total: 86,363 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 62897 - 149260:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 62897 - 110229:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg7_77

Search NORINE for peptide: strict or relaxed

AMP-binding (457..845): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASFLGGVYK
Nearest Stachelhaus code(s):: Ile DALFMGGVYK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1479..1869): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMKNLGTVSK
Nearest Stachelhaus code(s):: Asp DMKDLGMVDK (53% 8Å match)
Stachelhaus code match:: 70% (weak)

gnlProkkaPKFBICOC_9 - Region 1 - RRE-containing

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Location: 63,004 - 83,267 nt. (total: 20,264 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.