## Sat Jul 20 02:04:53 2024
## emapper-2.1.12
## /d223NFS/m128030022/anaconda3/envs/eggnog/bin/emapper.py -i /d223NFS/m128030014/NGP/gene_list/prokka_results/GCA_958347485.1/GCA_958347485.1.faa --temp_dir /d223NFS/m128030022/NGPs/NGPs_new/databases/NGPs_DB/NGPs_db/GCA_958347485.1/2.eggNOGmapper --output_dir /d223NFS/m128030022/NGPs/NGPs_new/databases/NGPs_DB/NGPs_db/GCA_958347485.1/2.eggNOGmapper --output eggNOG_out --override --cpu 20 -m diamond --sensmode fast
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
PKFBICOC_00001	1211844.CBLM010000055_gene429	4.02e-40	140.0	COG1329@1|root,COG1329@2|Bacteria,1V7IF@1239|Firmicutes,3VRZS@526524|Erysipelotrichia	526524|Erysipelotrichia	K	CarD-like/TRCF domain	-	-	-	-	-	-	-	-	-	-	-	-	CarD_CdnL_TRCF
PKFBICOC_00003	552398.HMPREF0866_02539	9.01e-129	384.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,3WG7U@541000|Ruminococcaceae	186801|Clostridia	G	Hydrolase Family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
PKFBICOC_00004	97139.C824_03631	2.55e-64	200.0	COG1671@1|root,COG1671@2|Bacteria,1V9Z0@1239|Firmicutes,24HPW@186801|Clostridia,36J4K@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0178 family	-	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
PKFBICOC_00005	1410628.JNKS01000019_gene1298	1.63e-81	249.0	COG0652@1|root,COG0652@2|Bacteria,1V1SP@1239|Firmicutes,24G4H@186801|Clostridia,27MJD@186928|unclassified Lachnospiraceae	186801|Clostridia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
PKFBICOC_00006	411467.BACCAP_01604	6.14e-90	275.0	COG1682@1|root,COG1682@2|Bacteria,1UY8J@1239|Firmicutes,24CN9@186801|Clostridia,26ACB@186813|unclassified Clostridiales	186801|Clostridia	GM	ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
PKFBICOC_00007	1280696.ATVY01000002_gene3515	3.09e-131	391.0	COG1134@1|root,COG1134@2|Bacteria,1TQKK@1239|Firmicutes,24A5V@186801|Clostridia,4BYR2@830|Butyrivibrio	186801|Clostridia	GM	ATPases associated with a variety of cellular activities	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
PKFBICOC_00008	428125.CLOLEP_01588	4.28e-84	255.0	COG0860@1|root,COG3103@1|root,COG0860@2|Bacteria,COG3103@2|Bacteria,1TQ50@1239|Firmicutes,249IF@186801|Clostridia,3WIH3@541000|Ruminococcaceae	186801|Clostridia	MT	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3,SPOR
PKFBICOC_00009	755731.Clo1100_3749	1.17e-74	232.0	COG1139@1|root,COG1139@2|Bacteria,1TP90@1239|Firmicutes,249B6@186801|Clostridia,36FNS@31979|Clostridiaceae	186801|Clostridia	C	LUD domain	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
PKFBICOC_00011	1120746.CCNL01000011_gene1609	3.12e-154	451.0	COG0144@1|root,COG3270@1|root,COG0144@2|Bacteria,COG3270@2|Bacteria,2NPE2@2323|unclassified Bacteria	2|Bacteria	J	N-terminal domain of 16S rRNA methyltransferase RsmF	rsmF	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176,2.1.1.178	ko:K03500,ko:K11392	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI
PKFBICOC_00012	1235835.C814_02088	1.05e-124	363.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia,3WGWE@541000|Ruminococcaceae	186801|Clostridia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
PKFBICOC_00014	610130.Closa_3038	0.0	1134.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,21XE0@1506553|Lachnoclostridium	186801|Clostridia	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
PKFBICOC_00015	500632.CLONEX_01238	1.03e-28	104.0	2EI1I@1|root,330GJ@2|Bacteria,1VEJT@1239|Firmicutes,24SAX@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00016	1408436.JHXY01000049_gene263	5.04e-46	149.0	COG2026@1|root,COG2026@2|Bacteria,1VEQK@1239|Firmicutes,24P2K@186801|Clostridia,25YYK@186806|Eubacteriaceae	186801|Clostridia	DJ	addiction module toxin, RelE StbE family	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
PKFBICOC_00017	246199.CUS_5738	4.83e-83	249.0	COG0221@1|root,COG0221@2|Bacteria,1V2DF@1239|Firmicutes,24G1A@186801|Clostridia,3WI3Y@541000|Ruminococcaceae	186801|Clostridia	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
PKFBICOC_00019	428125.CLOLEP_01578	2.93e-114	337.0	COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,248TD@186801|Clostridia,3WHV2@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
PKFBICOC_00020	1121334.KB911066_gene526	1.53e-140	407.0	COG0564@1|root,COG0564@2|Bacteria,1TR1M@1239|Firmicutes,248W3@186801|Clostridia,3WH5D@541000|Ruminococcaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
PKFBICOC_00022	1105031.HMPREF1141_3016	3.71e-103	325.0	COG1388@1|root,COG1388@2|Bacteria,1TSVC@1239|Firmicutes,248VQ@186801|Clostridia,36EW2@31979|Clostridiaceae	186801|Clostridia	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3794,LysM
PKFBICOC_00023	428125.CLOLEP_02350	2.5e-244	684.0	COG5019@1|root,COG5019@2|Bacteria,1UHVS@1239|Firmicutes,25E4Q@186801|Clostridia,3WGJE@541000|Ruminococcaceae	186801|Clostridia	DZ	ATPase. Has a role at an early stage in the morphogenesis of the spore coat	spoIVA	-	-	ko:K06398	-	-	-	-	ko00000	-	-	-	Spore_IV_A
PKFBICOC_00025	1120746.CCNL01000010_gene1410	7.21e-200	564.0	COG1883@1|root,COG1883@2|Bacteria,2NP19@2323|unclassified Bacteria	2|Bacteria	C	Na+-transporting oxaloacetate decarboxylase beta subunit	gcdB	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
PKFBICOC_00026	333138.LQ50_22235	5.58e-12	71.2	COG3944@1|root,COG3944@2|Bacteria,1UZCR@1239|Firmicutes,4HE26@91061|Bacilli,1ZBJ4@1386|Bacillus	91061|Bacilli	M	biosynthesis protein	ywqC	-	-	ko:K19420	-	-	-	-	ko00000	-	-	-	GNVR,Wzz
PKFBICOC_00027	525378.HMPREF0793_0770	1.3e-37	138.0	COG0489@1|root,COG0489@2|Bacteria,1TS4R@1239|Firmicutes,4HCEN@91061|Bacilli,4GXUA@90964|Staphylococcaceae	91061|Bacilli	D	ATPase MipZ	capB	-	-	-	-	-	-	-	-	-	-	-	AAA_31
PKFBICOC_00028	1120746.CCNL01000011_gene1841	4.17e-194	551.0	COG1167@1|root,COG1167@2|Bacteria	2|Bacteria	K	transaminase activity	aspT	-	-	-	-	-	-	-	-	-	-	-	Aminotran_MocR
PKFBICOC_00029	877411.JMMA01000002_gene2315	5.67e-138	422.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1TQVT@1239|Firmicutes,247X8@186801|Clostridia,3WGN7@541000|Ruminococcaceae	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF
PKFBICOC_00030	428125.CLOLEP_02702	1.03e-104	317.0	COG0341@1|root,COG0341@2|Bacteria,1TSZE@1239|Firmicutes,249A3@186801|Clostridia,3WGWX@541000|Ruminococcaceae	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
PKFBICOC_00031	1292035.H476_2990	3.54e-92	285.0	COG0803@1|root,COG0803@2|Bacteria,1TPG7@1239|Firmicutes,249VZ@186801|Clostridia,25R39@186804|Peptostreptococcaceae	186801|Clostridia	P	Belongs to the bacterial solute-binding protein 9 family	adcA	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
PKFBICOC_00032	1280696.ATVY01000006_gene865	5.18e-85	261.0	COG1121@1|root,COG1121@2|Bacteria,1TQ68@1239|Firmicutes,248F1@186801|Clostridia,4BWZ2@830|Butyrivibrio	186801|Clostridia	P	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
PKFBICOC_00033	903814.ELI_0567	3.39e-108	321.0	COG1108@1|root,COG1108@2|Bacteria,1TR79@1239|Firmicutes,24875@186801|Clostridia,25V63@186806|Eubacteriaceae	186801|Clostridia	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
PKFBICOC_00034	873449.STRCR_1758	2.72e-34	120.0	COG3620@1|root,COG3620@2|Bacteria,1VD4K@1239|Firmicutes	1239|Firmicutes	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
PKFBICOC_00036	1105031.HMPREF1141_1524	1.04e-59	193.0	COG2323@1|root,COG2323@2|Bacteria,1V3NW@1239|Firmicutes,24H1Q@186801|Clostridia,36DZ1@31979|Clostridiaceae	186801|Clostridia	K	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
PKFBICOC_00037	428125.CLOLEP_01990	2.55e-176	512.0	COG0697@1|root,COG0697@2|Bacteria,1TP7K@1239|Firmicutes,248Q8@186801|Clostridia,3WHDF@541000|Ruminococcaceae	186801|Clostridia	EG	spore germination protein	-	-	-	ko:K06295	-	-	-	-	ko00000	-	-	-	GerA
PKFBICOC_00040	1105031.HMPREF1141_2476	2.77e-141	409.0	COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,24999@186801|Clostridia,36F8F@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
PKFBICOC_00041	428125.CLOLEP_00067	1.51e-103	311.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,3WGX6@541000|Ruminococcaceae	186801|Clostridia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
PKFBICOC_00042	411471.SUBVAR_05034	9.12e-94	285.0	COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia,3WGDD@541000|Ruminococcaceae	186801|Clostridia	S	Displays ATPase and GTPase activities	yvcJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
PKFBICOC_00043	641112.ACOK01000097_gene901	1.62e-62	207.0	COG1481@1|root,COG1481@2|Bacteria,1TP2X@1239|Firmicutes,2484M@186801|Clostridia,3WHUA@541000|Ruminococcaceae	186801|Clostridia	K	May be required for sporulation	whiA	-	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
PKFBICOC_00044	545264.KB898746_gene691	5.17e-05	45.1	COG1722@1|root,COG1722@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease VII activity	xseB	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
PKFBICOC_00045	537013.CLOSTMETH_02773	2.22e-83	259.0	COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,248DE@186801|Clostridia,3WINP@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iHN637.CLJU_RS05465	polyprenyl_synt
PKFBICOC_00046	1410670.JHXF01000010_gene442	8.19e-209	604.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,3WGVF@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
PKFBICOC_00047	1121334.KB911066_gene622	2.91e-125	364.0	COG1189@1|root,COG1189@2|Bacteria,1TPE4@1239|Firmicutes,247VH@186801|Clostridia,3WGGG@541000|Ruminococcaceae	186801|Clostridia	J	Ribosomal RNA large subunit methyltransferase J	rrmJ	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
PKFBICOC_00048	314285.KT71_14354	3.65e-43	156.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1J7TZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iEcSMS35_1347.EcSMS35_2767	NAD_kinase
PKFBICOC_00049	1230342.CTM_12810	5.69e-40	138.0	COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,24HGQ@186801|Clostridia,36IRA@31979|Clostridiaceae	186801|Clostridia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
PKFBICOC_00050	428125.CLOLEP_03158	4.85e-156	464.0	COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia,3WHDP@541000|Ruminococcaceae	186801|Clostridia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
PKFBICOC_00051	428125.CLOLEP_03099	1.21e-232	670.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,3WI09@541000|Ruminococcaceae	186801|Clostridia	L	exonuclease	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
PKFBICOC_00052	428125.CLOLEP_03100	0.0	892.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,3WGUK@541000|Ruminococcaceae	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
PKFBICOC_00053	1160721.RBI_II00337	7.9e-56	179.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia,3WJM2@541000|Ruminococcaceae	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
PKFBICOC_00054	1235835.C814_01424	1.25e-48	165.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia,3WHAR@541000|Ruminococcaceae	186801|Clostridia	S	Metallo-beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
PKFBICOC_00055	428125.CLOLEP_03103	1.87e-180	521.0	COG0635@1|root,COG0635@2|Bacteria,1TREM@1239|Firmicutes,247JT@186801|Clostridia,3WGA8@541000|Ruminococcaceae	186801|Clostridia	C	Coproporphyrinogen dehydrogenase	hemZ	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
PKFBICOC_00057	1232666.JANE01000034_gene1675	8.1e-15	86.3	COG2244@1|root,COG2244@2|Bacteria,1TNYX@1239|Firmicutes,4H9RY@91061|Bacilli,4GXVB@90964|Staphylococcaceae	91061|Bacilli	S	Polysaccharide biosynthesis protein	ytgP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt,Polysacc_synt_C
PKFBICOC_00058	1121334.KB911066_gene924	7.07e-102	305.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,3WHY1@541000|Ruminococcaceae	186801|Clostridia	S	MazG family	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
PKFBICOC_00059	500635.MITSMUL_04770	1.19e-31	113.0	COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,4H539@909932|Negativicutes	909932|Negativicutes	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
PKFBICOC_00060	1282887.AUJG01000003_gene536	3.82e-32	113.0	COG1188@1|root,COG1188@2|Bacteria,1VEI5@1239|Firmicutes,24QNF@186801|Clostridia	186801|Clostridia	J	S4 domain protein	hslR	-	-	-	-	-	-	-	-	-	-	-	S4
PKFBICOC_00061	428125.CLOLEP_03271	5.45e-19	81.3	2E3ZZ@1|root,32YWW@2|Bacteria,1VEIW@1239|Firmicutes,24QNQ@186801|Clostridia,3WKKJ@541000|Ruminococcaceae	186801|Clostridia	S	Sporulation protein YabP	yabP	-	-	-	-	-	-	-	-	-	-	-	YabP
PKFBICOC_00062	663278.Ethha_0352	8.82e-10	59.7	COG2919@1|root,COG2919@2|Bacteria,1VKC5@1239|Firmicutes,24WD9@186801|Clostridia,3WMB8@541000|Ruminococcaceae	186801|Clostridia	D	Septum formation initiator	-	-	-	ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
PKFBICOC_00063	1235835.C814_00754	1.03e-37	134.0	COG1098@1|root,COG1098@2|Bacteria,1V6FE@1239|Firmicutes,24MPT@186801|Clostridia,3WJUX@541000|Ruminococcaceae	186801|Clostridia	J	S1 RNA binding domain	yugI	-	-	ko:K07570,ko:K07571	-	-	-	-	ko00000	-	-	-	S1
PKFBICOC_00064	1410670.JHXF01000021_gene2399	7.22e-44	150.0	COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,24HDH@186801|Clostridia,3WIX8@541000|Ruminococcaceae	186801|Clostridia	J	Sigma 54 modulation/S30EA ribosomal protein C terminus	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
PKFBICOC_00065	246199.CUS_7776	1.7e-133	393.0	COG0116@1|root,COG0116@2|Bacteria,1TP0X@1239|Firmicutes,248MA@186801|Clostridia,3WGN5@541000|Ruminococcaceae	186801|Clostridia	L	Belongs to the methyltransferase superfamily	ypsC	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
PKFBICOC_00067	428125.CLOLEP_00564	4.05e-99	291.0	COG3481@1|root,COG3481@2|Bacteria,1TQEK@1239|Firmicutes,24BRR@186801|Clostridia,3WIKZ@541000|Ruminococcaceae	186801|Clostridia	S	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
PKFBICOC_00068	428125.CLOLEP_03177	9.12e-297	830.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,3WGTP@541000|Ruminococcaceae	186801|Clostridia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
PKFBICOC_00070	1410616.JHXE01000007_gene1972	1.19e-28	105.0	COG3077@1|root,COG3077@2|Bacteria,1VEDW@1239|Firmicutes,24QJN@186801|Clostridia,3NHHH@46205|Pseudobutyrivibrio	186801|Clostridia	L	RelB antitoxin	-	-	-	ko:K07473	-	-	-	-	ko00000,ko02048	-	-	-	RelB
PKFBICOC_00071	519989.ECTPHS_13984	7.71e-36	123.0	COG4115@1|root,COG4115@2|Bacteria,1MZBP@1224|Proteobacteria,1S99Z@1236|Gammaproteobacteria,1WYX1@135613|Chromatiales	1236|Gammaproteobacteria	S	TIGRFAM Addiction module toxin, Txe YoeB	-	-	-	-	-	-	-	-	-	-	-	-	YoeB_toxin
PKFBICOC_00072	428125.CLOLEP_03176	1.03e-83	263.0	COG3854@1|root,COG3854@2|Bacteria,1TQ23@1239|Firmicutes,248S2@186801|Clostridia,3WGH3@541000|Ruminococcaceae	186801|Clostridia	S	stage III sporulation protein AA	spoIIIAA	-	-	ko:K06390	-	-	-	-	ko00000	-	-	-	T2SSE
PKFBICOC_00074	509191.AEDB02000109_gene5020	7.04e-19	79.0	2E555@1|root,32ZY3@2|Bacteria,1VEM4@1239|Firmicutes,24QNR@186801|Clostridia,3WKGF@541000|Ruminococcaceae	186801|Clostridia	S	stage III sporulation protein AC	spoIIIAC	-	-	ko:K06392	-	-	-	-	ko00000	-	-	-	SpoIIIAC
PKFBICOC_00075	537013.CLOSTMETH_02786	6.87e-19	83.6	2CPUI@1|root,32SJW@2|Bacteria,1VA9Y@1239|Firmicutes,24NK6@186801|Clostridia	186801|Clostridia	S	Stage III sporulation protein AD	spoIIIAD	-	-	ko:K06393	-	-	-	-	ko00000	-	-	-	SpoIIIAC
PKFBICOC_00076	1120746.CCNL01000011_gene1594	3.21e-56	195.0	2C2CG@1|root,2Z7PW@2|Bacteria	2|Bacteria	S	stage III sporulation protein AE	spoIIIAE	-	-	ko:K06394	-	-	-	-	ko00000	-	-	-	Spore_III_AE
PKFBICOC_00078	1232452.BAIB02000005_gene883	4.98e-12	67.4	2E6BB@1|root,330Z5@2|Bacteria,1VF3M@1239|Firmicutes,24RAX@186801|Clostridia,26CBE@186813|unclassified Clostridiales	186801|Clostridia	S	Stage III sporulation protein AG	spoIIIAG	-	-	ko:K06396	-	-	-	-	ko00000	-	-	-	-
PKFBICOC_00079	1121344.JHZO01000004_gene1612	3.88e-08	58.5	2E3US@1|root,32YS3@2|Bacteria	2|Bacteria	S	Stage III sporulation protein	spoIIIAH	-	-	ko:K06397	-	-	-	-	ko00000	1.A.34.1.1	-	-	SpoIIIAH
PKFBICOC_00080	428126.CLOSPI_00327	7.23e-29	110.0	COG1846@1|root,COG1846@2|Bacteria,1V9N7@1239|Firmicutes,3VQT9@526524|Erysipelotrichia	526524|Erysipelotrichia	K	Transcriptional regulator, MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
PKFBICOC_00081	411474.COPEUT_00371	1.65e-102	311.0	COG2364@1|root,COG2364@2|Bacteria,1UXHA@1239|Firmicutes,24AJQ@186801|Clostridia	186801|Clostridia	F	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00082	658086.HMPREF0994_03117	1.04e-22	94.4	COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,24MQ3@186801|Clostridia,27NBK@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
PKFBICOC_00083	641112.ACOK01000048_gene3892	1e-109	328.0	COG0533@1|root,COG0533@2|Bacteria,1TRPY@1239|Firmicutes,24CN4@186801|Clostridia,3WG7R@541000|Ruminococcaceae	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	gcp1	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
PKFBICOC_00084	394503.Ccel_1904	1.14e-117	355.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia,36EU5@31979|Clostridiaceae	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
PKFBICOC_00085	1120746.CCNL01000011_gene1888	0.0	1443.0	COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
PKFBICOC_00086	411471.SUBVAR_05052	4.3e-137	399.0	COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,3WHHG@541000|Ruminococcaceae	186801|Clostridia	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
PKFBICOC_00087	1469948.JPNB01000001_gene2244	3.74e-132	385.0	COG4120@1|root,COG4120@2|Bacteria,1TPDJ@1239|Firmicutes,249P1@186801|Clostridia,36EMV@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	BPD_transp_2
PKFBICOC_00088	622312.ROSEINA2194_02621	2.39e-134	387.0	COG1101@1|root,COG1101@2|Bacteria,1TPAN@1239|Firmicutes,247WW@186801|Clostridia	186801|Clostridia	S	Abc transporter	-	-	-	ko:K05833	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
PKFBICOC_00092	411460.RUMTOR_01013	4.06e-30	119.0	28RJ8@1|root,2ZDY4@2|Bacteria,1V64R@1239|Firmicutes,24HMT@186801|Clostridia,3Y20R@572511|Blautia	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00093	411463.EUBVEN_02379	2.67e-228	630.0	COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,2480D@186801|Clostridia,25V2T@186806|Eubacteriaceae	186801|Clostridia	E	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
PKFBICOC_00094	246199.CUS_4928	1.15e-108	330.0	COG2954@1|root,COG3911@1|root,COG2954@2|Bacteria,COG3911@2|Bacteria,1TQK3@1239|Firmicutes,24FBY@186801|Clostridia,3WJKT@541000|Ruminococcaceae	186801|Clostridia	S	CYTH	-	-	-	-	-	-	-	-	-	-	-	-	AAA_28,CYTH
PKFBICOC_00099	1160721.RBI_II00300	1.25e-307	852.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,3WH8S@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs1	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
PKFBICOC_00100	661087.HMPREF1008_00694	2.44e-63	194.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	yphJ	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD,Cupin_2
PKFBICOC_00102	1121334.KB911069_gene1487	1.04e-87	264.0	COG1394@1|root,COG1394@2|Bacteria,1TQ4P@1239|Firmicutes,24Z7J@186801|Clostridia,3WH3C@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
PKFBICOC_00103	1120746.CCNL01000013_gene1968	8.62e-278	766.0	COG1156@1|root,COG1156@2|Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
PKFBICOC_00104	428125.CLOLEP_03321	0.0	935.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,3WGBK@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	ntpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
PKFBICOC_00106	428125.CLOLEP_03319	1.88e-49	159.0	COG1436@1|root,COG1436@2|Bacteria,1VEN1@1239|Firmicutes,24K2E@186801|Clostridia,3WJWV@541000|Ruminococcaceae	186801|Clostridia	C	Archaeal vacuolar-type H -ATPase subunit F	-	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
PKFBICOC_00107	697329.Rumal_3162	5.04e-17	79.7	COG0636@1|root,COG0636@2|Bacteria,1VF4U@1239|Firmicutes,25CR4@186801|Clostridia,3WJIE@541000|Ruminococcaceae	186801|Clostridia	C	ATP synthase subunit C	ntpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
PKFBICOC_00108	1105031.HMPREF1141_2648	2.99e-198	579.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,36EI6@31979|Clostridiaceae	186801|Clostridia	U	Belongs to the V-ATPase 116 kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
PKFBICOC_00109	1120746.CCNL01000013_gene1962	1.44e-81	259.0	COG1527@1|root,COG1527@2|Bacteria	2|Bacteria	C	subunit (C	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
PKFBICOC_00111	908340.HMPREF9406_1343	6.29e-232	649.0	COG2848@1|root,COG2848@2|Bacteria,1TQG8@1239|Firmicutes,247K4@186801|Clostridia,36DX6@31979|Clostridiaceae	186801|Clostridia	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
PKFBICOC_00112	1160721.RBI_I00718	7.43e-29	106.0	COG3830@1|root,COG3830@2|Bacteria,1VENW@1239|Firmicutes,24QNV@186801|Clostridia,3WJVR@541000|Ruminococcaceae	186801|Clostridia	T	Belongs to the UPF0237 family	-	-	-	ko:K07166	-	-	-	-	ko00000	-	-	-	ACT_6
PKFBICOC_00113	515622.bpr_I2051	1.05e-36	138.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,4BXA3@830|Butyrivibrio	186801|Clostridia	E	PHP domain	hisK	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
PKFBICOC_00114	663278.Ethha_2193	9.63e-129	374.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,3WH3P@541000|Ruminococcaceae	186801|Clostridia	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
PKFBICOC_00115	1507.HMPREF0262_03702	1.47e-24	109.0	2E0TS@1|root,32WBE@2|Bacteria,1VBFI@1239|Firmicutes,24M0A@186801|Clostridia,36NAB@31979|Clostridiaceae	186801|Clostridia	S	Prokaryotic RING finger family 1	-	-	-	-	-	-	-	-	-	-	-	-	DUF2628,Prok-RING_1,zinc_ribbon_2
PKFBICOC_00116	428125.CLOLEP_00523	1.63e-194	548.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,3WG91@541000|Ruminococcaceae	186801|Clostridia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
PKFBICOC_00117	428125.CLOLEP_00764	3.03e-208	585.0	COG3635@1|root,COG3635@2|Bacteria,1TQ5S@1239|Firmicutes,248U6@186801|Clostridia,3WH2J@541000|Ruminococcaceae	186801|Clostridia	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
PKFBICOC_00119	272562.CA_C2387	1.52e-24	94.7	2E3FD@1|root,32YE7@2|Bacteria,1VEE4@1239|Firmicutes,24QJ7@186801|Clostridia,36MNV@31979|Clostridiaceae	186801|Clostridia	S	TSCPD domain	-	-	-	-	-	-	-	-	-	-	-	-	TSCPD
PKFBICOC_00120	428125.CLOLEP_00529	4.5e-74	240.0	COG3935@1|root,COG3935@2|Bacteria,1TPR5@1239|Firmicutes,248E7@186801|Clostridia,3WJJV@541000|Ruminococcaceae	186801|Clostridia	L	DnaD domain protein	dnaD	-	-	-	-	-	-	-	-	-	-	-	DnaB_2
PKFBICOC_00121	1120746.CCNL01000010_gene1368	9.41e-92	283.0	COG1484@1|root,COG1484@2|Bacteria	2|Bacteria	L	DNA-dependent DNA replication	-	-	-	ko:K02315,ko:K07452	-	-	-	-	ko00000,ko01000,ko02048,ko03032	-	-	-	AAA_5,DUF4357,IstB_IS21
PKFBICOC_00125	428125.CLOLEP_01918	6.36e-313	878.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,3WGKX@541000|Ruminococcaceae	186801|Clostridia	L	ATP-dependent DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
PKFBICOC_00126	1499684.CCNP01000018_gene1805	1.48e-52	188.0	COG1680@1|root,COG1680@2|Bacteria,1TRR5@1239|Firmicutes,249KP@186801|Clostridia,36H4V@31979|Clostridiaceae	186801|Clostridia	V	beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase,Cu_amine_oxidN1,DUF3471
PKFBICOC_00127	428125.CLOLEP_01917	1.04e-69	224.0	28J28@1|root,2Z8YU@2|Bacteria,1UYKD@1239|Firmicutes,24GNR@186801|Clostridia,3WHPZ@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00128	574375.BAGA_29485	3.46e-84	273.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,4HB2U@91061|Bacilli,1ZB5R@1386|Bacillus	91061|Bacilli	K	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
PKFBICOC_00129	428125.CLOLEP_02021	2.69e-217	614.0	COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,3WG85@541000|Ruminococcaceae	186801|Clostridia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iHN637.CLJU_RS20420	Mur_ligase_C,Mur_ligase_M
PKFBICOC_00130	877411.JMMA01000002_gene1095	1.6e-87	273.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,24BAN@186801|Clostridia,3WG8E@541000|Ruminococcaceae	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
PKFBICOC_00131	877411.JMMA01000002_gene1096	8.38e-106	320.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,248D0@186801|Clostridia,3WGHW@541000|Ruminococcaceae	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Peptidase_M42
PKFBICOC_00133	428125.CLOLEP_02025	5.8e-207	583.0	COG4100@1|root,COG4100@2|Bacteria,1TQ88@1239|Firmicutes,247Y4@186801|Clostridia,3WGF6@541000|Ruminococcaceae	186801|Clostridia	P	Cystathionine beta-lyase family protein involved in aluminum resistance	ynbB	-	-	-	-	-	-	-	-	-	-	-	Met_gamma_lyase
PKFBICOC_00134	411483.FAEPRAA2165_00680	2.79e-51	167.0	COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,24JM2@186801|Clostridia,3WJHQ@541000|Ruminococcaceae	186801|Clostridia	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
PKFBICOC_00135	428125.CLOLEP_00048	1.11e-25	114.0	COG1266@1|root,COG1266@2|Bacteria,1VKW2@1239|Firmicutes,24QJG@186801|Clostridia,3WM89@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
PKFBICOC_00138	1121334.KB911072_gene2558	2.84e-133	381.0	COG0152@1|root,COG0152@2|Bacteria,1TP11@1239|Firmicutes,2483I@186801|Clostridia,3WGZE@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the SAICAR synthetase family	purC	-	4.3.2.2,6.3.2.6	ko:K01756,ko:K01923	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559,R04591	RC00064,RC00162,RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
PKFBICOC_00139	428125.CLOLEP_03229	1.1e-248	694.0	COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia,3WH6T@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
PKFBICOC_00140	428125.CLOLEP_03228	6.6e-279	770.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia,3WG9P@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
PKFBICOC_00141	428125.CLOLEP_03227	2.94e-259	716.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,3WGUF@541000|Ruminococcaceae	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
PKFBICOC_00142	641112.ACOK01000001_gene3581	7.68e-280	776.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,3WGXK@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
PKFBICOC_00143	1226325.HMPREF1548_00767	3.84e-42	143.0	COG4639@1|root,COG4639@2|Bacteria,1V2CI@1239|Firmicutes,24HR3@186801|Clostridia,36J7U@31979|Clostridiaceae	186801|Clostridia	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
PKFBICOC_00144	1000588.HMPREF9965_1829	1.01e-55	178.0	COG1051@1|root,COG1051@2|Bacteria,1V6PF@1239|Firmicutes,4HKTF@91061|Bacilli,2TPT6@28037|Streptococcus mitis	91061|Bacilli	F	NUDIX domain	mutX	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
PKFBICOC_00145	1506994.JNLQ01000003_gene3793	5.64e-112	334.0	28JAP@1|root,2Z95J@2|Bacteria,1V602@1239|Firmicutes,24C5F@186801|Clostridia,4C1RS@830|Butyrivibrio	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00146	748224.HMPREF9436_00728	2.25e-151	429.0	COG0730@1|root,COG0730@2|Bacteria,1TRFG@1239|Firmicutes,24AEX@186801|Clostridia,3WH0U@541000|Ruminococcaceae	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
PKFBICOC_00147	457396.CSBG_01643	7.57e-67	220.0	COG1609@1|root,COG1609@2|Bacteria,1TPZJ@1239|Firmicutes,248K0@186801|Clostridia,36FT7@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
PKFBICOC_00148	411462.DORLON_02853	2.29e-232	652.0	COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,247VA@186801|Clostridia	186801|Clostridia	G	Psort location CytoplasmicMembrane, score 10.00	lacS	-	-	ko:K03292,ko:K11104,ko:K16209	-	-	-	-	ko00000,ko02000	2.A.2,2.A.2.1,2.A.2.2	-	-	MFS_2
PKFBICOC_00149	1123075.AUDP01000038_gene223	1.32e-189	540.0	COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,247U8@186801|Clostridia,3WHNU@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the GHMP kinase family	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
PKFBICOC_00150	1232447.BAHW02000028_gene2239	2.28e-196	549.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,2689A@186813|unclassified Clostridiales	186801|Clostridia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
PKFBICOC_00151	1235802.C823_02334	6.45e-233	656.0	COG4468@1|root,COG4468@2|Bacteria,1TPBN@1239|Firmicutes,247ZN@186801|Clostridia,25VII@186806|Eubacteriaceae	186801|Clostridia	G	Psort location Cytoplasmic, score	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
PKFBICOC_00152	556261.HMPREF0240_04024	1.32e-89	280.0	COG2017@1|root,COG2017@2|Bacteria,1TQGJ@1239|Firmicutes,249DZ@186801|Clostridia,36F59@31979|Clostridiaceae	186801|Clostridia	G	Converts alpha-aldose to the beta-anomer	mro	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
PKFBICOC_00153	1469948.JPNB01000001_gene447	1.71e-79	256.0	2F3Y4@1|root,33WQ6@2|Bacteria,1UKAG@1239|Firmicutes,24JVD@186801|Clostridia	186801|Clostridia	M	Psort location CytoplasmicMembrane, score 9.99	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
PKFBICOC_00156	693746.OBV_32590	7.76e-31	138.0	28NUE@1|root,2ZBST@2|Bacteria,1V25Z@1239|Firmicutes,24H99@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00157	877411.JMMA01000002_gene1631	6.32e-106	317.0	COG1131@1|root,COG1131@2|Bacteria,1TRJH@1239|Firmicutes,247XQ@186801|Clostridia,3WHDX@541000|Ruminococcaceae	186801|Clostridia	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
PKFBICOC_00158	1120971.AUCA01000007_gene2156	2.87e-08	57.0	COG1585@1|root,COG1585@2|Bacteria,1VCUJ@1239|Firmicutes,4HPB4@91061|Bacilli	91061|Bacilli	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
PKFBICOC_00159	1105031.HMPREF1141_2114	7.53e-123	360.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia,36EWT@31979|Clostridiaceae	186801|Clostridia	O	SPFH domain Band 7 family	qmcA	-	-	-	-	-	-	-	-	-	-	-	Band_7
PKFBICOC_00160	1235800.C819_01113	4.16e-77	256.0	COG4905@1|root,COG4905@2|Bacteria,1TQUM@1239|Firmicutes,25CKD@186801|Clostridia,27J1N@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Putative ABC-transporter type IV	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_CmpB
PKFBICOC_00161	1384065.JAGS01000001_gene2814	2.51e-74	227.0	COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,24HCB@186801|Clostridia,3WITM@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
PKFBICOC_00162	1160721.RBI_II00080	1.5e-166	485.0	COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia,3WH6T@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
PKFBICOC_00163	428125.CLOLEP_02078	4.97e-184	519.0	COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,248BT@186801|Clostridia,3WHKH@541000|Ruminococcaceae	186801|Clostridia	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
PKFBICOC_00164	1120746.CCNL01000011_gene1814	4.52e-94	280.0	COG0299@1|root,COG0299@2|Bacteria,2NPFD@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2,6.3.2.6,6.3.4.13	ko:K11175,ko:K13713	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04144,R04325,R04326,R04591	RC00026,RC00064,RC00090,RC00162,RC00166,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04225	Formyl_trans_N,YjbR
PKFBICOC_00165	1160721.RBI_II00077	4.78e-129	371.0	COG3363@1|root,COG3363@2|Bacteria,1TRA7@1239|Firmicutes,249ZW@186801|Clostridia,3WGGF@541000|Ruminococcaceae	186801|Clostridia	F	IMP cyclohydrolase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	IMP_cyclohyd
PKFBICOC_00166	1122931.AUAE01000009_gene4706	2.33e-239	663.0	COG0138@1|root,COG0138@2|Bacteria,4NIY8@976|Bacteroidetes,2FMYP@200643|Bacteroidia	976|Bacteroidetes	F	AICARFT IMPCHase bienzyme	purH2	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas
PKFBICOC_00167	428125.CLOLEP_02083	2.76e-221	620.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,3WGPD@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
PKFBICOC_00168	428125.CLOLEP_03274	3.46e-108	320.0	COG2201@1|root,COG2201@2|Bacteria,1VQS3@1239|Firmicutes,25E3X@186801|Clostridia,3WGU4@541000|Ruminococcaceae	186801|Clostridia	NT	May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process	spo0A	-	-	ko:K03413,ko:K07699	ko02020,ko02024,ko02030,map02020,map02024,map02030	M00485,M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg,Spo0A_C
PKFBICOC_00169	509191.AEDB02000109_gene5077	4.91e-69	229.0	COG0750@1|root,COG0750@2|Bacteria,1TPIR@1239|Firmicutes,24AFA@186801|Clostridia,3WHID@541000|Ruminococcaceae	186801|Clostridia	M	Stage IV sporulation protein B	spoIVB	-	3.4.21.116	ko:K06399	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S55
PKFBICOC_00170	1120746.CCNL01000010_gene1377	9.88e-219	642.0	COG0474@1|root,COG0474@2|Bacteria	2|Bacteria	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	-	-	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
PKFBICOC_00171	537013.CLOSTMETH_01463	5.5e-127	381.0	COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,3WGBR@541000|Ruminococcaceae	186801|Clostridia	J	tRNA nucleotidyltransferase poly(A) polymerase	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
PKFBICOC_00172	457421.CBFG_01643	3.39e-122	354.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia,2689B@186813|unclassified Clostridiales	186801|Clostridia	E	Psort location CytoplasmicMembrane, score	glnQ	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
PKFBICOC_00173	1410625.JHWK01000002_gene560	3.05e-159	469.0	COG0765@1|root,COG0834@1|root,COG0765@2|Bacteria,COG0834@2|Bacteria,1TPM3@1239|Firmicutes,248UY@186801|Clostridia,27JFR@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Binding-protein-dependent transport system inner membrane component	ArtM	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1,SBP_bac_3
PKFBICOC_00174	693746.OBV_25700	3.89e-204	573.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,2N6WZ@216572|Oscillospiraceae	186801|Clostridia	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
PKFBICOC_00175	873513.HMPREF6485_0820	1.01e-144	459.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,SLH
PKFBICOC_00176	1120746.CCNL01000010_gene1247	1.36e-197	568.0	COG2509@1|root,COG2509@2|Bacteria	2|Bacteria	H	5-formyltetrahydrofolate cyclo-ligase activity	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_binding_3,GIDA,HI0933_like,Pyr_redox_2
PKFBICOC_00177	86416.Clopa_4831	3.55e-89	283.0	COG2081@1|root,COG2081@2|Bacteria,1TR7U@1239|Firmicutes,2497W@186801|Clostridia,36EA5@31979|Clostridiaceae	186801|Clostridia	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
PKFBICOC_00178	515620.EUBELI_00888	6.08e-70	215.0	COG2426@1|root,COG2426@2|Bacteria,1V3UW@1239|Firmicutes,24HSW@186801|Clostridia,25WA3@186806|Eubacteriaceae	186801|Clostridia	S	small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
PKFBICOC_00179	1304866.K413DRAFT_1842	1.77e-22	94.7	COG5652@1|root,COG5652@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	VanZ
PKFBICOC_00180	428125.CLOLEP_02353	1.24e-149	441.0	COG0534@1|root,COG0534@2|Bacteria,1TP5P@1239|Firmicutes,247PQ@186801|Clostridia,3WHF6@541000|Ruminococcaceae	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	MatE
PKFBICOC_00182	489825.LYNGBM3L_56700	0.000175	48.9	COG1994@1|root,COG1994@2|Bacteria,1G05Y@1117|Cyanobacteria,1H8MI@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the peptidase M50B family	-	-	-	ko:K06402	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
PKFBICOC_00183	1120746.CCNL01000011_gene1718	0.0	911.0	COG1032@1|root,COG1032@2|Bacteria,2NNKI@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
PKFBICOC_00184	1120746.CCNL01000011_gene1719	1.04e-66	211.0	COG5011@1|root,COG5011@2|Bacteria	2|Bacteria	C	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
PKFBICOC_00186	33035.JPJF01000008_gene1233	1.72e-123	362.0	COG1242@1|root,COG1242@2|Bacteria,1TQ57@1239|Firmicutes,247U3@186801|Clostridia,3XYHJ@572511|Blautia	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	ytqA	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
PKFBICOC_00189	1120746.CCNL01000011_gene1788	1.89e-136	390.0	COG0528@1|root,COG0528@2|Bacteria,2NNRY@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS06240	AA_kinase
PKFBICOC_00190	1160721.RBI_II00035	7.44e-67	209.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,3WIRX@541000|Ruminococcaceae	186801|Clostridia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
PKFBICOC_00191	1105031.HMPREF1141_0177	9.64e-109	320.0	COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,36DDR@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
PKFBICOC_00192	1235835.C814_01567	3.93e-39	145.0	COG0575@1|root,COG0575@2|Bacteria,1UPNB@1239|Firmicutes,248BP@186801|Clostridia,3WH2Z@541000|Ruminococcaceae	186801|Clostridia	I	Psort location CytoplasmicMembrane, score 10.00	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
PKFBICOC_00193	428125.CLOLEP_02963	7.04e-160	461.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,2483M@186801|Clostridia,3WGCN@541000|Ruminococcaceae	186801|Clostridia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06420	DXPR_C,DXP_redisom_C,DXP_reductoisom
PKFBICOC_00194	428125.CLOLEP_02964	1.17e-59	207.0	COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,3WGQW@541000|Ruminococcaceae	186801|Clostridia	M	Metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
PKFBICOC_00195	428125.CLOLEP_02965	5.12e-186	524.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,3WGBA@541000|Ruminococcaceae	186801|Clostridia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430	GcpE
PKFBICOC_00196	428125.CLOLEP_02966	0.0	1857.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,3WGJN@541000|Ruminococcaceae	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K02342,ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
PKFBICOC_00197	596315.HMPREF0634_0411	1.09e-61	212.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia,25QVB@186804|Peptostreptococcaceae	186801|Clostridia	S	AI-2E family transporter	yhhT	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
PKFBICOC_00198	1120746.CCNL01000011_gene1780	6.38e-132	390.0	COG3705@1|root,COG3705@2|Bacteria,2NQXE@2323|unclassified Bacteria	2|Bacteria	E	Histidyl-tRNA synthetase	hisZ	-	2.4.2.17,6.1.1.21	ko:K00765,ko:K01892,ko:K02502	ko00340,ko00970,ko01100,ko01110,ko01230,map00340,map00970,map01100,map01110,map01230	M00026,M00359,M00360	R01071,R03655	RC00055,RC00523,RC02819,RC03200	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_His
PKFBICOC_00199	1120746.CCNL01000011_gene1779	2.56e-108	316.0	COG0040@1|root,COG0040@2|Bacteria,2NPCD@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
PKFBICOC_00200	428125.CLOLEP_02970	6.18e-213	599.0	COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia,3WGCJ@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
PKFBICOC_00201	641112.ACOK01000104_gene601	1.11e-116	348.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,3WGEN@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
PKFBICOC_00202	428125.CLOLEP_02972	2.65e-87	261.0	COG0131@1|root,COG0131@2|Bacteria,1TRH7@1239|Firmicutes,247WC@186801|Clostridia,3WH5P@541000|Ruminococcaceae	186801|Clostridia	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
PKFBICOC_00203	1235835.C814_00219	8.86e-93	279.0	COG0106@1|root,COG0106@2|Bacteria,1V1IR@1239|Firmicutes,24GBJ@186801|Clostridia,3WH1N@541000|Ruminococcaceae	186801|Clostridia	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
PKFBICOC_00204	1232443.BAIA02000077_gene312	1.36e-60	187.0	COG0139@1|root,COG0139@2|Bacteria,1UYNA@1239|Firmicutes,247RS@186801|Clostridia	186801|Clostridia	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05760	His_biosynth,PRA-CH,PRA-PH
PKFBICOC_00205	428125.CLOLEP_02974	2.67e-55	174.0	COG0140@1|root,COG0140@2|Bacteria,1VB6S@1239|Firmicutes,24MP1@186801|Clostridia,3WJ8Q@541000|Ruminococcaceae	186801|Clostridia	E	Phosphoribosyl-ATP	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
PKFBICOC_00207	428125.CLOLEP_02630	5.06e-167	483.0	COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,3WG80@541000|Ruminococcaceae	186801|Clostridia	J	tRNA methylthiotransferase YqeV	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
PKFBICOC_00208	1120746.CCNL01000012_gene1927	5.83e-109	334.0	COG1649@1|root,COG1649@2|Bacteria,2NP67@2323|unclassified Bacteria	2|Bacteria	S	Glycosyl hydrolase-like 10	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,GHL10
PKFBICOC_00209	398512.JQKC01000007_gene1164	1.55e-17	78.2	COG3326@1|root,COG3326@2|Bacteria,1VEJY@1239|Firmicutes,24QJW@186801|Clostridia,3WKTD@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1294)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1294
PKFBICOC_00210	1410617.JHXH01000013_gene23	9.77e-68	219.0	COG0564@1|root,COG0564@2|Bacteria,1TS1T@1239|Firmicutes,249AH@186801|Clostridia,3WI75@541000|Ruminococcaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD_2	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
PKFBICOC_00212	5888.CAK75268	2e-06	60.1	KOG0032@1|root,KOG0032@2759|Eukaryota	2759|Eukaryota	T	protein serine/threonine kinase activity	-	GO:0000075,GO:0000077,GO:0000278,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007030,GO:0007049,GO:0007093,GO:0007095,GO:0007154,GO:0007165,GO:0007346,GO:0008150,GO:0008152,GO:0008361,GO:0009987,GO:0010256,GO:0010389,GO:0010564,GO:0010948,GO:0010972,GO:0016043,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018105,GO:0018107,GO:0018193,GO:0018209,GO:0018210,GO:0019538,GO:0022402,GO:0023052,GO:0031570,GO:0031572,GO:0032535,GO:0033554,GO:0035556,GO:0036211,GO:0042770,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0044773,GO:0044774,GO:0044818,GO:0045786,GO:0045792,GO:0045930,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051726,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0072395,GO:0072401,GO:0072413,GO:0072422,GO:0090066,GO:0140096,GO:1901564,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1902402,GO:1902403,GO:1902749,GO:1902750,GO:1903047	2.7.11.1	ko:K08269,ko:K13412	ko04136,ko04138,ko04139,ko04140,ko04150,ko04212,ko04626,ko05145,map04136,map04138,map04139,map04140,map04150,map04212,map04626,map05145	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03029,ko04131	-	-	-	DCX,EF-hand_1,EF-hand_5,EF-hand_7,Pkinase
PKFBICOC_00214	428125.CLOLEP_03125	1.41e-15	75.1	COG1862@1|root,COG1862@2|Bacteria	2|Bacteria	U	protein transport	yajC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
PKFBICOC_00215	1120746.CCNL01000011_gene1750	8.23e-215	599.0	COG0343@1|root,COG0343@2|Bacteria,2NNQS@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
PKFBICOC_00216	246199.CUS_6206	1.15e-179	508.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,3WGMR@541000|Ruminococcaceae	186801|Clostridia	H	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
PKFBICOC_00217	428125.CLOLEP_03139	4.31e-202	566.0	COG0136@1|root,COG0136@2|Bacteria,1TPC6@1239|Firmicutes,248ZR@186801|Clostridia,3WGVU@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the aspartate-semialdehyde dehydrogenase family	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
PKFBICOC_00218	1120746.CCNL01000011_gene1753	3.5e-128	374.0	COG0329@1|root,COG0329@2|Bacteria,2NP5Q@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1521	DHDPS
PKFBICOC_00219	428125.CLOLEP_03141	1.88e-105	312.0	COG0289@1|root,COG0289@2|Bacteria,1TR9D@1239|Firmicutes,248FY@186801|Clostridia,3WH3Y@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17035	DapB_C,DapB_N
PKFBICOC_00221	428125.CLOLEP_03096	1.31e-134	397.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,3WH06@541000|Ruminococcaceae	186801|Clostridia	E	cysteine desulfurase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
PKFBICOC_00222	411483.FAEPRAA2165_01954	2.95e-63	208.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,249K8@186801|Clostridia,3WGY9@541000|Ruminococcaceae	186801|Clostridia	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
PKFBICOC_00223	1235790.C805_00433	1.65e-09	68.2	COG4856@1|root,COG4856@2|Bacteria,1TSIV@1239|Firmicutes,24GKC@186801|Clostridia,25W2Z@186806|Eubacteriaceae	186801|Clostridia	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
PKFBICOC_00224	428125.CLOLEP_03338	5.28e-114	345.0	COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,247WS@186801|Clostridia,3WJ15@541000|Ruminococcaceae	186801|Clostridia	D	Belongs to the SEDS family	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
PKFBICOC_00225	428125.CLOLEP_03336	4.28e-312	861.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,3WHBU@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
PKFBICOC_00226	1120746.CCNL01000013_gene1976	2.34e-61	192.0	COG0802@1|root,COG0802@2|Bacteria,2NPU4@2323|unclassified Bacteria	2|Bacteria	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	yjeE	-	2.7.1.221	ko:K06925,ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	TsaE
PKFBICOC_00227	1105031.HMPREF1141_2858	1.27e-63	205.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,36EHE@31979|Clostridiaceae	186801|Clostridia	O	Glycoprotease	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
PKFBICOC_00228	428125.CLOLEP_03333	5.3e-71	217.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,3WJA1@541000|Ruminococcaceae	186801|Clostridia	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
PKFBICOC_00229	428125.CLOLEP_02009	3.01e-38	129.0	COG1396@1|root,COG1396@2|Bacteria,1VJNB@1239|Firmicutes,24TZB@186801|Clostridia	186801|Clostridia	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19
PKFBICOC_00230	1384065.JAGS01000001_gene3244	7.99e-155	456.0	COG2865@1|root,COG2865@2|Bacteria,1U8FY@1239|Firmicutes,24B8W@186801|Clostridia,3WJKE@541000|Ruminococcaceae	186801|Clostridia	K	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2,HATPase_c_4,HTH_24
PKFBICOC_00232	1095747.HMPREF1049_0631	7.28e-118	362.0	COG0732@1|root,COG0732@2|Bacteria,378P5@32066|Fusobacteria	32066|Fusobacteria	L	Type I restriction modification DNA specificity domain	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
PKFBICOC_00233	1122917.KB899676_gene150	1.02e-230	647.0	COG0286@1|root,COG0286@2|Bacteria,1TPGZ@1239|Firmicutes,4HDKR@91061|Bacilli,274X0@186822|Paenibacillaceae	91061|Bacilli	V	N-6 DNA Methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
PKFBICOC_00234	428125.CLOLEP_03823	0.0	1810.0	COG4096@1|root,COG4096@2|Bacteria,1UI7V@1239|Firmicutes,25ED3@186801|Clostridia,3WIR6@541000|Ruminococcaceae	186801|Clostridia	L	COG COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF4145,EcoEI_R_C,HSDR_N,HSDR_N_2,Helicase_C,ResIII
PKFBICOC_00235	428127.EUBDOL_02158	0.0	938.0	COG2909@1|root,COG4637@1|root,COG2909@2|Bacteria,COG4637@2|Bacteria,1TQ9X@1239|Firmicutes,3VPTX@526524|Erysipelotrichia	526524|Erysipelotrichia	K	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA-ATPase_like,PDDEXK_9
PKFBICOC_00236	585394.RHOM_15120	6.44e-19	78.6	2C3TZ@1|root,33DSH@2|Bacteria,1VM6H@1239|Firmicutes,254ZM@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00237	411463.EUBVEN_01864	3.75e-111	337.0	COG0571@1|root,COG0571@2|Bacteria,1UYIA@1239|Firmicutes,24CBC@186801|Clostridia,25Y4U@186806|Eubacteriaceae	186801|Clostridia	K	Double-stranded RNA binding motif	-	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
PKFBICOC_00238	1121334.KB911073_gene1924	2.77e-65	202.0	COG3773@1|root,COG3773@2|Bacteria,1V4KW@1239|Firmicutes,24GK5@186801|Clostridia,3WJ6D@541000|Ruminococcaceae	186801|Clostridia	M	cell wall hydrolase	-	-	3.5.1.28	ko:K01449	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Hydrolase_2
PKFBICOC_00239	428125.CLOLEP_03844	7.71e-28	111.0	2E8BQ@1|root,332QD@2|Bacteria,1VH5U@1239|Firmicutes,24R1P@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00241	1519439.JPJG01000058_gene2064	1.14e-99	306.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,2N6V9@216572|Oscillospiraceae	186801|Clostridia	H	HemN C-terminal domain	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
PKFBICOC_00242	1105031.HMPREF1141_1128	1.24e-295	816.0	COG4108@1|root,COG4108@2|Bacteria,1TPYT@1239|Firmicutes,247X3@186801|Clostridia,36DUQ@31979|Clostridiaceae	186801|Clostridia	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
PKFBICOC_00243	1232452.BAIB02000021_gene2819	9.6e-113	347.0	COG1982@1|root,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia	186801|Clostridia	E	Orn Lys Arg decarboxylase major	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
PKFBICOC_00244	97138.C820_02724	1.28e-10	57.0	2EGRK@1|root,33AHS@2|Bacteria,1VK9R@1239|Firmicutes,24UM0@186801|Clostridia,36N0I@31979|Clostridiaceae	186801|Clostridia	S	Six-cysteine peptide SCIFF	scfA	-	-	-	-	-	-	-	-	-	-	-	SCIFF
PKFBICOC_00245	411483.FAEPRAA2165_01520	6.16e-279	769.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,3WGAH@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM	scfB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
PKFBICOC_00246	1268240.ATFI01000013_gene1110	3.28e-110	326.0	COG1234@1|root,COG1234@2|Bacteria,4NH9K@976|Bacteroidetes,2FP6X@200643|Bacteroidia,4AP3W@815|Bacteroidaceae	976|Bacteroidetes	S	Psort location Cytoplasmic, score 8.96	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
PKFBICOC_00247	445972.ANACOL_03047	4.5e-211	613.0	COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,3WH9H@541000|Ruminococcaceae	186801|Clostridia	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB2	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
PKFBICOC_00248	1232446.BAIE02000048_gene178	7.31e-12	62.4	COG1918@1|root,COG1918@2|Bacteria,1VK8Z@1239|Firmicutes	1239|Firmicutes	P	Fe2 transport system protein A	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
PKFBICOC_00249	411474.COPEUT_00855	1.87e-104	351.0	COG1657@1|root,COG3209@1|root,COG4733@1|root,COG1657@2|Bacteria,COG3209@2|Bacteria,COG4733@2|Bacteria,1UZVS@1239|Firmicutes,24DV2@186801|Clostridia	186801|Clostridia	I	Leucine-rich repeat (LRR) protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,DUF4430,Prenyltrans,SLH,SQHop_cyclase_C
PKFBICOC_00250	1121289.JHVL01000037_gene3042	1.76e-76	241.0	COG1657@1|root,COG1657@2|Bacteria,1VBUR@1239|Firmicutes,24F29@186801|Clostridia,36HXY@31979|Clostridiaceae	186801|Clostridia	I	Domain of unknown function (DUF4430)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4430
PKFBICOC_00251	138119.DSY3852	3.34e-107	320.0	COG0619@1|root,COG0619@2|Bacteria,1TSB5@1239|Firmicutes,24AN7@186801|Clostridia,2616E@186807|Peptococcaceae	186801|Clostridia	P	PFAM Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
PKFBICOC_00252	138119.DSY3851	0.0	950.0	COG1129@1|root,COG4720@1|root,COG1129@2|Bacteria,COG4720@2|Bacteria,1TQRP@1239|Firmicutes,24YCF@186801|Clostridia,267B9@186807|Peptococcaceae	186801|Clostridia	G	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,ECF-ribofla_trS,ECF_trnsprt
PKFBICOC_00253	411474.COPEUT_02205	9.87e-308	843.0	COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia	186801|Clostridia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF_1	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
PKFBICOC_00254	1203606.HMPREF1526_02111	5.3e-161	456.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,36DNY@31979|Clostridiaceae	186801|Clostridia	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24,SEC-C
PKFBICOC_00255	1462527.CCDM010000001_gene2293	1.45e-15	82.8	COG0860@1|root,COG3103@1|root,COG0860@2|Bacteria,COG3103@2|Bacteria,1UYPW@1239|Firmicutes,4HBVT@91061|Bacilli,23J9E@182709|Oceanobacillus	91061|Bacilli	MT	Ami_3	lytC_3	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3
PKFBICOC_00256	1120746.CCNL01000011_gene1739	1.48e-227	638.0	COG1066@1|root,COG1066@2|Bacteria,2NNQG@2323|unclassified Bacteria	2|Bacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
PKFBICOC_00257	1105031.HMPREF1141_3059	4.28e-35	131.0	28NR9@1|root,2ZBQJ@2|Bacteria,1UZEN@1239|Firmicutes,24G0V@186801|Clostridia,36I0Y@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00258	1120746.CCNL01000011_gene1743	5.25e-136	396.0	COG4974@1|root,COG4974@2|Bacteria,2NP4H@2323|unclassified Bacteria	2|Bacteria	L	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
PKFBICOC_00259	742765.HMPREF9457_01771	9.5e-255	706.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,27V70@189330|Dorea	186801|Clostridia	C	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
PKFBICOC_00260	537013.CLOSTMETH_00988	1.02e-15	71.6	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,252JX@186801|Clostridia,3WKI0@541000|Ruminococcaceae	186801|Clostridia	K	Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
PKFBICOC_00261	1280698.AUJS01000005_gene2807	1.38e-108	318.0	COG3619@1|root,COG3619@2|Bacteria,1V1VQ@1239|Firmicutes,24DUE@186801|Clostridia,27VY4@189330|Dorea	186801|Clostridia	S	Protein of unknown function (DUF1275)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1275
PKFBICOC_00262	1121334.KB911066_gene589	3.08e-210	592.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,3WHCB@541000|Ruminococcaceae	186801|Clostridia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS18870	Orn_Arg_deC_N,Orn_DAP_Arg_deC
PKFBICOC_00263	1507.HMPREF0262_00789	2.25e-58	189.0	COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,36EDR@31979|Clostridiaceae	186801|Clostridia	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
PKFBICOC_00264	1120746.CCNL01000011_gene1732	2.73e-301	853.0	COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
PKFBICOC_00265	1121334.KB911066_gene586	6.42e-198	562.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,3WGYG@541000|Ruminococcaceae	186801|Clostridia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
PKFBICOC_00266	428125.CLOLEP_02375	6.23e-107	311.0	COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,247QY@186801|Clostridia,3WGQP@541000|Ruminococcaceae	186801|Clostridia	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
PKFBICOC_00267	428125.CLOLEP_02374	6.13e-148	434.0	COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia,3WGS8@541000|Ruminococcaceae	186801|Clostridia	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
PKFBICOC_00268	1235835.C814_00651	6.41e-91	274.0	COG1768@1|root,COG1768@2|Bacteria,1V3XB@1239|Firmicutes,249BN@186801|Clostridia,3WIIA@541000|Ruminococcaceae	186801|Clostridia	S	Ser Thr phosphatase family protein	-	-	-	ko:K07099	-	-	-	-	ko00000	-	-	-	Metallophos
PKFBICOC_00269	428125.CLOLEP_02372	1.23e-228	645.0	COG0498@1|root,COG0498@2|Bacteria,1TPR0@1239|Firmicutes,248YY@186801|Clostridia,3WGWF@541000|Ruminococcaceae	186801|Clostridia	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS16355	PALP,Thr_synth_N
PKFBICOC_00270	1378168.N510_03492	1.6e-52	182.0	COG2355@1|root,COG2355@2|Bacteria,1UA7M@1239|Firmicutes	1239|Firmicutes	E	Dipeptidase	dp2	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
PKFBICOC_00271	272562.CA_C1763	5.1e-20	85.9	COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,36MV2@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
PKFBICOC_00272	1507.HMPREF0262_00800	6.05e-71	221.0	COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,248IT@186801|Clostridia,36DHX@31979|Clostridiaceae	186801|Clostridia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
PKFBICOC_00273	428125.CLOLEP_02368	3.3e-143	411.0	COG1161@1|root,COG1161@2|Bacteria,1TQGK@1239|Firmicutes,2490H@186801|Clostridia,3WGB7@541000|Ruminococcaceae	186801|Clostridia	S	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity	ylqF	-	-	ko:K14540	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1
PKFBICOC_00274	634956.Geoth_2156	1.09e-12	70.9	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,4HIQ4@91061|Bacilli	91061|Bacilli	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
PKFBICOC_00275	1410670.JHXF01000010_gene542	1.19e-30	120.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24MVR@186801|Clostridia,3WSDM@541000|Ruminococcaceae	186801|Clostridia	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
PKFBICOC_00276	428125.CLOLEP_02366	4.03e-59	184.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia,3WJ8U@541000|Ruminococcaceae	186801|Clostridia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
PKFBICOC_00277	1121334.KB911070_gene1291	4.02e-125	367.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,3WGKV@541000|Ruminococcaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
PKFBICOC_00278	644966.Tmar_0892	8.96e-27	107.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia,3WDCK@538999|Clostridiales incertae sedis	186801|Clostridia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
PKFBICOC_00279	428125.CLOLEP_01959	0.0	1390.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,3WG9B@541000|Ruminococcaceae	186801|Clostridia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
PKFBICOC_00280	411471.SUBVAR_05058	3.32e-21	97.1	COG3599@1|root,COG3599@2|Bacteria,1VGCY@1239|Firmicutes,24TVY@186801|Clostridia,3WM0J@541000|Ruminococcaceae	186801|Clostridia	D	DivIVA domain protein	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
PKFBICOC_00281	386415.NT01CX_1947	4.33e-26	109.0	COG2302@1|root,COG2302@2|Bacteria,1U5V2@1239|Firmicutes,24GDV@186801|Clostridia,36IWC@31979|Clostridiaceae	186801|Clostridia	S	S4 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	S4
PKFBICOC_00282	1105031.HMPREF1141_2200	2.35e-62	196.0	COG1799@1|root,COG1799@2|Bacteria,1VER3@1239|Firmicutes,24I9Y@186801|Clostridia,36I3V@31979|Clostridiaceae	186801|Clostridia	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	-	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
PKFBICOC_00283	428125.CLOLEP_01955	4.81e-92	278.0	COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,3WGKD@541000|Ruminococcaceae	186801|Clostridia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	ylmE	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
PKFBICOC_00284	1121334.KB911070_gene1297	9.1e-62	213.0	COG0845@1|root,COG0845@2|Bacteria,1V9GB@1239|Firmicutes,24HX2@186801|Clostridia,3WJMC@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00285	877411.JMMA01000002_gene1215	5.96e-101	306.0	COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia,3WGGD@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
PKFBICOC_00286	1105031.HMPREF1141_2196	2.71e-219	636.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,36EVN@31979|Clostridiaceae	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
PKFBICOC_00287	1120746.CCNL01000011_gene1863	0.0	1054.0	COG0249@1|root,COG0249@2|Bacteria,2NNN6@2323|unclassified Bacteria	2|Bacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
PKFBICOC_00289	1507.HMPREF0262_00298	1.39e-26	98.6	2BRIM@1|root,32KHM@2|Bacteria,1US5F@1239|Firmicutes,24S12@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00291	759913.SDSE_0284	2.82e-30	107.0	COG1476@1|root,COG1476@2|Bacteria,1VERT@1239|Firmicutes,4HNID@91061|Bacilli,1MA5A@119603|Streptococcus dysgalactiae group	91061|Bacilli	K	Cro/C1-type HTH DNA-binding domain	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
PKFBICOC_00292	428125.CLOLEP_01481	1.22e-150	425.0	COG0822@1|root,COG0822@2|Bacteria,1TQEQ@1239|Firmicutes,248ID@186801|Clostridia,3WGYK@541000|Ruminococcaceae	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	NifU_N
PKFBICOC_00293	428125.CLOLEP_01479	1.82e-202	565.0	2C4R5@1|root,2Z7JK@2|Bacteria,1TQIE@1239|Firmicutes,24879@186801|Clostridia,3WGV8@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	GGGtGRT
PKFBICOC_00294	410358.Mlab_0596	1.87e-16	82.8	arCOG07861@1|root,arCOG07861@2157|Archaea	2157|Archaea	S	CpXC protein	-	-	-	-	-	-	-	-	-	-	-	-	CpXC
PKFBICOC_00296	428125.CLOLEP_02467	0.0	1382.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,3WGW6@541000|Ruminococcaceae	186801|Clostridia	I	CoA-substrate-specific enzyme activase	hgdC2	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
PKFBICOC_00297	428125.CLOLEP_02468	2.72e-203	575.0	COG3581@1|root,COG3581@2|Bacteria,1TRVV@1239|Firmicutes,24947@186801|Clostridia,3WH15@541000|Ruminococcaceae	186801|Clostridia	I	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
PKFBICOC_00298	702459.BBPR_1112	3.98e-89	273.0	COG2865@1|root,COG2865@2|Bacteria,2IF0U@201174|Actinobacteria,4D0I9@85004|Bifidobacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00299	411473.RUMCAL_00604	4.23e-67	234.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,3WH0E@541000|Ruminococcaceae	186801|Clostridia	O	Trypsin-like serine proteases typically periplasmic contain C-terminal PDZ domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
PKFBICOC_00300	1121115.AXVN01000099_gene787	6.48e-186	519.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,3XZ5J@572511|Blautia	186801|Clostridia	G	Psort location Cytoplasmic, score 8.87	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
PKFBICOC_00301	397287.C807_02623	3.26e-53	174.0	COG1268@1|root,COG1268@2|Bacteria,1VAY6@1239|Firmicutes,24HPU@186801|Clostridia,27NIJ@186928|unclassified Lachnospiraceae	186801|Clostridia	S	BioY family	bioY	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
PKFBICOC_00303	428125.CLOLEP_03718	9.19e-180	525.0	COG0772@1|root,COG0772@2|Bacteria,1TQ82@1239|Firmicutes,248QS@186801|Clostridia,3WI08@541000|Ruminococcaceae	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FHA,FTSW_RODA_SPOVE
PKFBICOC_00304	1120746.CCNL01000008_gene473	8.31e-153	449.0	COG0768@1|root,COG0768@2|Bacteria	2|Bacteria	M	penicillin binding	-	-	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
PKFBICOC_00305	428125.CLOLEP_00213	0.0	1325.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,3WGPN@541000|Ruminococcaceae	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
PKFBICOC_00307	1410670.JHXF01000012_gene2098	6.34e-10	68.6	COG4932@1|root,COG4932@2|Bacteria,1UXYC@1239|Firmicutes,24GBW@186801|Clostridia,3WKET@541000|Ruminococcaceae	186801|Clostridia	M	Gram-positive pilin backbone subunit 2, Cna-B-like domain	-	-	-	-	-	-	-	-	-	-	-	-	GramPos_pilinBB,Gram_pos_anchor
PKFBICOC_00308	742741.HMPREF9475_00291	1.81e-62	205.0	COG3764@1|root,COG3764@2|Bacteria,1UN9R@1239|Firmicutes,24CEQ@186801|Clostridia,2215Z@1506553|Lachnoclostridium	186801|Clostridia	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
PKFBICOC_00309	180332.JTGN01000005_gene3042	1.03e-37	140.0	COG3764@1|root,COG3764@2|Bacteria,1V3I1@1239|Firmicutes,24IU2@186801|Clostridia	186801|Clostridia	M	Sortase family	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
PKFBICOC_00314	1121344.JHZO01000006_gene1882	2.48e-200	569.0	COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,2481R@186801|Clostridia,3WHBI@541000|Ruminococcaceae	186801|Clostridia	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
PKFBICOC_00315	411473.RUMCAL_02159	3.16e-131	380.0	COG0685@1|root,COG0685@2|Bacteria,1TQFE@1239|Firmicutes,247ZK@186801|Clostridia,3WH1U@541000|Ruminococcaceae	186801|Clostridia	E	5,10-methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
PKFBICOC_00316	515620.EUBELI_01383	7.36e-65	207.0	COG1410@1|root,COG1410@2|Bacteria,1V7JJ@1239|Firmicutes,24AE1@186801|Clostridia,25WR6@186806|Eubacteriaceae	186801|Clostridia	E	NOG21937 non supervised orthologous group	metH2	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_synt_B12
PKFBICOC_00317	246199.CUS_7787	0.0	979.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,3WH5Y@541000|Ruminococcaceae	186801|Clostridia	E	Psort location Cytoplasmic, score	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
PKFBICOC_00318	875454.BAEW01000002_gene430	7.28e-14	71.2	COG4416@1|root,COG4416@2|Bacteria,1VEMD@1239|Firmicutes,24MRR@186801|Clostridia,22HV7@1570339|Peptoniphilaceae	186801|Clostridia	S	COG NOG18757 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00319	428125.CLOLEP_02455	0.0	1914.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia,3WH0Y@541000|Ruminococcaceae	186801|Clostridia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
PKFBICOC_00320	515620.EUBELI_00022	1.2e-71	235.0	COG1376@1|root,COG1376@2|Bacteria,1UK0I@1239|Firmicutes,249X8@186801|Clostridia,25W21@186806|Eubacteriaceae	186801|Clostridia	V	L,D-transpeptidase catalytic domain	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Cu_amine_oxidN1,DUF5011,YkuD
PKFBICOC_00321	483218.BACPEC_02832	6.83e-74	226.0	2943S@1|root,2ZRIE@2|Bacteria,1V3J6@1239|Firmicutes,24HEP@186801|Clostridia,26B99@186813|unclassified Clostridiales	186801|Clostridia	S	Psort location Cytoplasmic, score	KatE	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00322	1196322.A370_05925	2.23e-58	186.0	COG1713@1|root,COG1713@2|Bacteria,1UJ6P@1239|Firmicutes,25EWR@186801|Clostridia,36UST@31979|Clostridiaceae	186801|Clostridia	H	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
PKFBICOC_00323	1256908.HMPREF0373_02733	0.0	1319.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,25VH6@186806|Eubacteriaceae	186801|Clostridia	C	Psort location Cytoplasmic, score	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
PKFBICOC_00324	1256908.HMPREF0373_02731	1.45e-137	393.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,247NA@186801|Clostridia,25VM2@186806|Eubacteriaceae	186801|Clostridia	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
PKFBICOC_00325	931626.Awo_c13900	3.67e-86	288.0	COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,2491Y@186801|Clostridia,25X42@186806|Eubacteriaceae	186801|Clostridia	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
PKFBICOC_00328	991.IW20_13940	1.97e-47	160.0	COG1045@1|root,COG1045@2|Bacteria,4NUIU@976|Bacteroidetes,1I56E@117743|Flavobacteriia	976|Bacteroidetes	E	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
PKFBICOC_00329	1282887.AUJG01000006_gene267	4.86e-81	260.0	COG1035@1|root,COG1143@1|root,COG1035@2|Bacteria,COG1143@2|Bacteria,1TQGA@1239|Firmicutes,249BE@186801|Clostridia	186801|Clostridia	C	Coenzyme F420-reducing hydrogenase beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7,FrhB_FdhB_C,FrhB_FdhB_N
PKFBICOC_00330	357809.Cphy_3682	1.2e-79	255.0	COG2327@1|root,COG2327@2|Bacteria,1V4VX@1239|Firmicutes,24C2N@186801|Clostridia,223PJ@1506553|Lachnoclostridium	186801|Clostridia	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
PKFBICOC_00331	272134.KB731324_gene4066	1.68e-67	220.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PKFBICOC_00332	77635.BISU_1988	1.13e-75	254.0	COG2244@1|root,COG2244@2|Bacteria,2I92W@201174|Actinobacteria,4D06Y@85004|Bifidobacteriales	201174|Actinobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00333	1410638.JHXJ01000020_gene934	9.51e-44	162.0	COG1143@1|root,COG1143@2|Bacteria,1UIAW@1239|Firmicutes,24MKT@186801|Clostridia,3WRCB@541000|Ruminococcaceae	186801|Clostridia	C	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
PKFBICOC_00334	411463.EUBVEN_01479	1.44e-20	100.0	COG3307@1|root,COG3307@2|Bacteria,1VGVE@1239|Firmicutes,24SDV@186801|Clostridia	186801|Clostridia	M	Psort location CytoplasmicMembrane, score 9.99	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
PKFBICOC_00335	326426.Bbr_0445	2.81e-42	156.0	COG0463@1|root,COG0463@2|Bacteria,2I2GT@201174|Actinobacteria,4D2Y3@85004|Bifidobacteriales	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PKFBICOC_00336	470145.BACCOP_00205	1.35e-92	290.0	COG1035@1|root,COG1035@2|Bacteria,4NG86@976|Bacteroidetes,2FMH7@200643|Bacteroidia,4AQUN@815|Bacteroidaceae	976|Bacteroidetes	C	coenzyme F420-reducing hydrogenase beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,Fer4_7,FrhB_FdhB_C,FrhB_FdhB_N
PKFBICOC_00337	1077285.AGDG01000029_gene1266	7.05e-83	265.0	COG2327@1|root,COG2327@2|Bacteria,4P3VK@976|Bacteroidetes,2FPPT@200643|Bacteroidia,4AKBI@815|Bacteroidaceae	976|Bacteroidetes	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
PKFBICOC_00338	180332.JTGN01000005_gene3065	9.11e-153	446.0	COG0438@1|root,COG0438@2|Bacteria,1V0JW@1239|Firmicutes,24CKB@186801|Clostridia	186801|Clostridia	M	Glycosyltransferase, group 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
PKFBICOC_00339	1230342.CTM_10046	1.23e-62	209.0	COG1442@1|root,COG1442@2|Bacteria,1VD1B@1239|Firmicutes,25BZQ@186801|Clostridia,36WMD@31979|Clostridiaceae	1239|Firmicutes	M	COG1442 Lipopolysaccharide biosynthesis proteins, LPS glycosyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_8
PKFBICOC_00340	1123288.SOV_3c03190	1.06e-99	293.0	COG1898@1|root,COG1898@2|Bacteria,1V2VG@1239|Firmicutes,4H7IN@909932|Negativicutes	909932|Negativicutes	M	dTDP-4-dehydrorhamnose 3,5-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	dTDP_sugar_isom
PKFBICOC_00341	1235803.C825_04476	1.15e-108	325.0	COG0451@1|root,COG0451@2|Bacteria,4NT4N@976|Bacteroidetes,2FU55@200643|Bacteroidia	976|Bacteroidetes	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
PKFBICOC_00342	931276.Cspa_c54140	7.81e-193	541.0	COG0451@1|root,COG0451@2|Bacteria,1TQW7@1239|Firmicutes,24BI6@186801|Clostridia,36EA9@31979|Clostridiaceae	186801|Clostridia	M	CDP-glucose 4,6-dehydratase	rfbG	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
PKFBICOC_00343	483216.BACEGG_01568	7.93e-133	382.0	COG1208@1|root,COG1208@2|Bacteria,4NG3V@976|Bacteroidetes,2FMH2@200643|Bacteroidia,4ANN2@815|Bacteroidaceae	976|Bacteroidetes	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon)	rfbF	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
PKFBICOC_00344	1294142.CINTURNW_0470	4.93e-88	266.0	COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,24870@186801|Clostridia,36EMM@31979|Clostridiaceae	186801|Clostridia	M	sugar transferase	-	-	2.7.8.6	ko:K00996	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Bac_transf,CoA_binding_3
PKFBICOC_00345	1385520.N802_00195	6.26e-32	129.0	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,4FFZV@85021|Intrasporangiaceae	201174|Actinobacteria	DM	biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,ParA,Wzz
PKFBICOC_00346	1120972.AUMH01000027_gene1575	7.64e-22	97.4	COG3944@1|root,COG3944@2|Bacteria,1UZCR@1239|Firmicutes,4HE26@91061|Bacilli,27A55@186823|Alicyclobacillaceae	91061|Bacilli	M	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
PKFBICOC_00348	537013.CLOSTMETH_00769	6.97e-69	218.0	COG3764@1|root,COG3764@2|Bacteria,1V9CM@1239|Firmicutes,24UPX@186801|Clostridia,3WMIS@541000|Ruminococcaceae	186801|Clostridia	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
PKFBICOC_00350	428125.CLOLEP_02541	1.17e-98	295.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,3WGAW@541000|Ruminococcaceae	186801|Clostridia	L	Hydrolase, TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
PKFBICOC_00351	1160721.RBI_I01468	0.0	1045.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,3WGEI@541000|Ruminococcaceae	186801|Clostridia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
PKFBICOC_00352	483218.BACPEC_00627	1.23e-221	623.0	COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,268FU@186813|unclassified Clostridiales	186801|Clostridia	S	Sodium:neurotransmitter symporter family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
PKFBICOC_00353	428125.CLOLEP_01967	0.0	936.0	COG0855@1|root,COG0855@2|Bacteria,1TNZM@1239|Firmicutes,248XY@186801|Clostridia,3WGAB@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
PKFBICOC_00354	428125.CLOLEP_01968	1.41e-184	521.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia,3WGG1@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
PKFBICOC_00356	1507.HMPREF0262_01420	7.36e-39	134.0	COG2315@1|root,COG2315@2|Bacteria,1V4K7@1239|Firmicutes,25AZA@186801|Clostridia,36W6P@31979|Clostridiaceae	186801|Clostridia	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
PKFBICOC_00358	1105031.HMPREF1141_1414	1.98e-117	349.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,36E02@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
PKFBICOC_00359	428125.CLOLEP_03259	5.39e-250	692.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,3WGJK@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
PKFBICOC_00361	1460634.JCM19037_1588	1.02e-14	72.0	COG0758@1|root,COG0758@2|Bacteria,1VNFT@1239|Firmicutes,4HZZP@91061|Bacilli	91061|Bacilli	LU	Protein of unknown function (DUF2493)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2493
PKFBICOC_00362	1487921.DP68_09690	5.76e-07	55.8	COG0671@1|root,COG0671@2|Bacteria,1VF2U@1239|Firmicutes,24D98@186801|Clostridia,36I34@31979|Clostridiaceae	186801|Clostridia	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,SNARE_assoc
PKFBICOC_00363	1507.HMPREF0262_02714	1.03e-128	379.0	COG0183@1|root,COG0183@2|Bacteria,1UHVW@1239|Firmicutes,248BM@186801|Clostridia,36DQK@31979|Clostridiaceae	186801|Clostridia	I	Stage V sporulation protein AD	spoVAD	-	-	ko:K06406	-	-	-	-	ko00000	-	-	-	SpoVAD
PKFBICOC_00364	1094508.Tsac_2492	1.35e-28	127.0	COG2720@1|root,COG2720@2|Bacteria,1TSH8@1239|Firmicutes,2493X@186801|Clostridia,42EY6@68295|Thermoanaerobacterales	186801|Clostridia	V	PFAM VanW family protein	-	-	-	ko:K18346	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01504	-	-	-	G5,PG_binding_4,VanW
PKFBICOC_00365	428125.CLOLEP_00385	1.95e-91	286.0	COG0707@1|root,COG0707@2|Bacteria,1UQ6A@1239|Firmicutes,248FR@186801|Clostridia,3WIYK@541000|Ruminococcaceae	186801|Clostridia	M	UDP-N-acetylglucosamine LPS N-acetylglucosamine transferase	-	-	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,MGDG_synth
PKFBICOC_00366	509191.AEDB02000042_gene4898	1.41e-20	101.0	COG4826@1|root,COG4826@2|Bacteria,1UYKX@1239|Firmicutes,24B76@186801|Clostridia,3WGCD@541000|Ruminococcaceae	186801|Clostridia	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Dockerin_1,Serpin
PKFBICOC_00367	428125.CLOLEP_01561	6.26e-278	768.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,3WGJQ@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
PKFBICOC_00368	1120746.CCNL01000011_gene1544	0.0	927.0	COG0008@1|root,COG0008@2|Bacteria,2NNRW@2323|unclassified Bacteria	2|Bacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECIAI39_1322.ECIAI39_0637	tRNA-synt_1c,tRNA-synt_1c_C
PKFBICOC_00369	1121334.KB911067_gene286	7.67e-94	283.0	COG1028@1|root,COG1028@2|Bacteria,1TZY6@1239|Firmicutes,248QZ@186801|Clostridia,3WIP8@541000|Ruminococcaceae	186801|Clostridia	IQ	Oxidoreductase, short chain dehydrogenase reductase family protein	fabG5	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
PKFBICOC_00370	1121334.KB911077_gene2436	5.21e-206	586.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,3WHE3@541000|Ruminococcaceae	186801|Clostridia	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
PKFBICOC_00371	1499683.CCFF01000016_gene785	3.55e-74	245.0	COG2182@1|root,COG2182@2|Bacteria,1VRPK@1239|Firmicutes,24Y63@186801|Clostridia,36W96@31979|Clostridiaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K15770	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	SBP_bac_8
PKFBICOC_00372	1499683.CCFF01000016_gene784	9.07e-173	502.0	COG1175@1|root,COG1175@2|Bacteria,1TR2A@1239|Firmicutes,247MA@186801|Clostridia,36E1M@31979|Clostridiaceae	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
PKFBICOC_00373	699246.HMPREF0868_0183	2.81e-119	350.0	COG3833@1|root,COG3833@2|Bacteria,1TRB7@1239|Firmicutes,248A7@186801|Clostridia	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15772	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
PKFBICOC_00374	1408416.JNJT01000013_gene455	3.01e-108	341.0	COG0366@1|root,COG0366@2|Bacteria,3WSUF@544448|Tenericutes	544448|Tenericutes	G	alpha-amylase	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
PKFBICOC_00375	428125.CLOLEP_03944	5.61e-87	256.0	COG0048@1|root,COG0048@2|Bacteria,1V1FJ@1239|Firmicutes,24FQT@186801|Clostridia,3WIHG@541000|Ruminococcaceae	186801|Clostridia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
PKFBICOC_00376	1232443.BAIA02000045_gene2222	1.9e-94	277.0	COG0049@1|root,COG0049@2|Bacteria,1V1GG@1239|Firmicutes,24FQN@186801|Clostridia,268CC@186813|unclassified Clostridiales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
PKFBICOC_00377	428125.CLOLEP_03946	0.0	1149.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,3WGEG@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
PKFBICOC_00378	1120746.CCNL01000011_gene1565	2.07e-264	727.0	COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria	2|Bacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
PKFBICOC_00379	1410632.JHWW01000005_gene745	3.44e-134	385.0	COG1476@1|root,COG1476@2|Bacteria,1UUSK@1239|Firmicutes,247YW@186801|Clostridia,27KQ6@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Putative zinc ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Zn_ribbon_2
PKFBICOC_00380	428125.CLOLEP_02456	7.05e-52	169.0	2ANER@1|root,31DDD@2|Bacteria,1V46U@1239|Firmicutes,24JDI@186801|Clostridia,3WJNA@541000|Ruminococcaceae	186801|Clostridia	S	stage V sporulation protein AC	spoVAC	-	-	ko:K06405	-	-	-	-	ko00000	-	-	-	SpoVAC_SpoVAEB
PKFBICOC_00381	1120746.CCNL01000004_gene82	2.67e-135	398.0	COG1104@1|root,COG1104@2|Bacteria	2|Bacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
PKFBICOC_00382	428125.CLOLEP_01204	5.4e-175	500.0	COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia,3WGMK@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
PKFBICOC_00383	1120746.CCNL01000004_gene85	7.46e-70	238.0	COG4509@1|root,COG4509@2|Bacteria	2|Bacteria	S	Sortase family	srtB	-	3.4.22.70	ko:K08600	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	CinA,MoCF_biosynth,Sortase,SpoIID
PKFBICOC_00385	411473.RUMCAL_01858	6.27e-255	702.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,25E6I@186801|Clostridia,3WIMR@541000|Ruminococcaceae	186801|Clostridia	E	Cys Met metabolism	megL	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
PKFBICOC_00387	428125.CLOLEP_03255	2.71e-126	372.0	COG0739@1|root,COG0739@2|Bacteria,1TQMQ@1239|Firmicutes,24B3J@186801|Clostridia,3WHG5@541000|Ruminococcaceae	186801|Clostridia	M	Peptidase, M23	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
PKFBICOC_00388	218140.BPSY_2072	3.18e-06	52.0	2B7HD@1|root,320MD@2|Bacteria,2H4CZ@201174|Actinobacteria,4D264@85004|Bifidobacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF4854)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4854
PKFBICOC_00389	742738.HMPREF9460_00707	1.1e-171	497.0	COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,248V4@186801|Clostridia,268JH@186813|unclassified Clostridiales	186801|Clostridia	M	MBOAT, membrane-bound O-acyltransferase family	algI	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
PKFBICOC_00390	1408437.JNJN01000003_gene1583	5.8e-72	236.0	28IAA@1|root,2Z8CW@2|Bacteria,1TQHP@1239|Firmicutes,248TG@186801|Clostridia,25WPI@186806|Eubacteriaceae	186801|Clostridia	S	DHHW protein	-	-	-	-	-	-	-	-	-	-	-	-	DHHW
PKFBICOC_00391	1121296.JONJ01000015_gene150	1.27e-36	132.0	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia,220HY@1506553|Lachnoclostridium	186801|Clostridia	H	ATP corrinoid adenosyltransferase	btuR	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
PKFBICOC_00392	1121334.KB911071_gene2124	5.19e-61	188.0	COG0051@1|root,COG0051@2|Bacteria,1V6C9@1239|Firmicutes,24JDC@186801|Clostridia,3WJB6@541000|Ruminococcaceae	186801|Clostridia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
PKFBICOC_00393	1121334.KB911071_gene2123	2.86e-114	331.0	COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,3WHH0@541000|Ruminococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
PKFBICOC_00394	428125.CLOLEP_01035	3.25e-114	331.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,3WGQT@541000|Ruminococcaceae	186801|Clostridia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
PKFBICOC_00395	411467.BACCAP_02877	6.99e-34	119.0	COG0089@1|root,COG0089@2|Bacteria,1VA4W@1239|Firmicutes,24MN8@186801|Clostridia,269KV@186813|unclassified Clostridiales	186801|Clostridia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
PKFBICOC_00396	428125.CLOLEP_01033	9.27e-168	471.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,3WGQK@541000|Ruminococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
PKFBICOC_00397	537013.CLOSTMETH_00184	9.8e-56	174.0	COG0185@1|root,COG0185@2|Bacteria,1V6CX@1239|Firmicutes,24JN3@186801|Clostridia,3WJ9F@541000|Ruminococcaceae	186801|Clostridia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
PKFBICOC_00398	428125.CLOLEP_01031	2.1e-53	169.0	COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,24JF4@186801|Clostridia,3WJ9K@541000|Ruminococcaceae	186801|Clostridia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
PKFBICOC_00399	411473.RUMCAL_00581	6.3e-113	330.0	COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,24833@186801|Clostridia,3WGIF@541000|Ruminococcaceae	186801|Clostridia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
PKFBICOC_00400	428125.CLOLEP_01029	1.13e-86	256.0	COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,3WIIZ@541000|Ruminococcaceae	186801|Clostridia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
PKFBICOC_00401	1121334.KB911071_gene2115	1.12e-21	86.3	COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,24QV1@186801|Clostridia,3WKVV@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
PKFBICOC_00402	97138.C820_00864	6.8e-42	138.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,36KIV@31979|Clostridiaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
PKFBICOC_00403	428125.CLOLEP_01026	4.07e-76	228.0	COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,24H98@186801|Clostridia,3WITX@541000|Ruminococcaceae	186801|Clostridia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
PKFBICOC_00404	428125.CLOLEP_01025	4.2e-59	183.0	COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,24MY0@186801|Clostridia,3WJBH@541000|Ruminococcaceae	186801|Clostridia	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
PKFBICOC_00405	1121334.KB911071_gene2111	6.02e-110	318.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,247X0@186801|Clostridia,3WGYQ@541000|Ruminococcaceae	186801|Clostridia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
PKFBICOC_00406	1280694.AUJQ01000004_gene453	7.72e-35	119.0	COG0199@1|root,COG0199@2|Bacteria,1VEF6@1239|Firmicutes,24QR1@186801|Clostridia,3NHEX@46205|Pseudobutyrivibrio	186801|Clostridia	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
PKFBICOC_00407	428125.CLOLEP_01022	2.44e-75	226.0	COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,24HCP@186801|Clostridia,3WIYN@541000|Ruminococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
PKFBICOC_00408	428125.CLOLEP_01021	1.26e-96	284.0	COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,2496R@186801|Clostridia,3WIFT@541000|Ruminococcaceae	186801|Clostridia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
PKFBICOC_00409	1203606.HMPREF1526_02681	2.82e-52	167.0	COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,24JCS@186801|Clostridia,36JQ0@31979|Clostridiaceae	186801|Clostridia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
PKFBICOC_00410	1105031.HMPREF1141_0331	1.6e-89	265.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,24G5D@186801|Clostridia,36DG4@31979|Clostridiaceae	186801|Clostridia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
PKFBICOC_00411	537013.CLOSTMETH_00170	8.27e-24	90.9	COG1841@1|root,COG1841@2|Bacteria,1UG5U@1239|Firmicutes,24RUS@186801|Clostridia,3WKJT@541000|Ruminococcaceae	186801|Clostridia	J	ribosomal protein	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
PKFBICOC_00412	1121334.KB911071_gene2105	1.39e-65	203.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia,3WIV7@541000|Ruminococcaceae	186801|Clostridia	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
PKFBICOC_00413	1105031.HMPREF1141_0328	1.71e-208	588.0	COG0201@1|root,COG0201@2|Bacteria,1TPHB@1239|Firmicutes,248T9@186801|Clostridia,36F8Y@31979|Clostridiaceae	186801|Clostridia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
PKFBICOC_00414	1235835.C814_02981	2.92e-100	296.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,3WHQ6@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
PKFBICOC_00415	428125.CLOLEP_01014	1.61e-140	401.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,3WGEW@541000|Ruminococcaceae	186801|Clostridia	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
PKFBICOC_00416	537013.CLOSTMETH_00165	3.13e-14	68.6	COG2163@1|root,COG2163@2|Bacteria,1VEPA@1239|Firmicutes,24UP0@186801|Clostridia,3WMRS@541000|Ruminococcaceae	186801|Clostridia	J	COG2163 Ribosomal protein L14E L6E L27E	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00417	500635.MITSMUL_05084	1.51e-33	117.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,4H53Q@909932|Negativicutes	909932|Negativicutes	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
PKFBICOC_00418	999415.HMPREF9943_00576	9.35e-15	66.6	COG0257@1|root,COG0257@2|Bacteria,1VK4F@1239|Firmicutes,3VSAE@526524|Erysipelotrichia	526524|Erysipelotrichia	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_L36
PKFBICOC_00419	428125.CLOLEP_01010	3.22e-73	220.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,3WJ08@541000|Ruminococcaceae	186801|Clostridia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
PKFBICOC_00420	1120746.CCNL01000017_gene2989	6.28e-70	213.0	COG0100@1|root,COG0100@2|Bacteria,2NPCN@2323|unclassified Bacteria	2|Bacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
PKFBICOC_00421	1519439.JPJG01000018_gene271	2.09e-95	283.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,2N67X@216572|Oscillospiraceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
PKFBICOC_00422	428125.CLOLEP_01007	6.18e-185	519.0	COG0202@1|root,COG0202@2|Bacteria,1TPR8@1239|Firmicutes,248DS@186801|Clostridia,3WGUM@541000|Ruminococcaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
PKFBICOC_00423	428125.CLOLEP_01006	8.13e-56	176.0	COG0203@1|root,COG0203@2|Bacteria,1V6JQ@1239|Firmicutes,24J9T@186801|Clostridia,3WIRR@541000|Ruminococcaceae	186801|Clostridia	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
PKFBICOC_00425	658086.HMPREF0994_01376	6.32e-33	142.0	COG1705@1|root,COG1705@2|Bacteria,1UMKN@1239|Firmicutes,25GKA@186801|Clostridia,27IXC@186928|unclassified Lachnospiraceae	186801|Clostridia	NU	CotH kinase protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH
PKFBICOC_00426	521460.Athe_1266	3.55e-124	381.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,42F1S@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
PKFBICOC_00427	289377.HL41_01960	3.75e-19	87.0	COG0703@1|root,COG0703@2|Bacteria,2GI06@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
PKFBICOC_00428	665956.HMPREF1032_03995	4.57e-67	213.0	COG1191@1|root,COG1191@2|Bacteria,1V296@1239|Firmicutes,24GTU@186801|Clostridia,3WGPV@541000|Ruminococcaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family	sigF	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
PKFBICOC_00429	1410670.JHXF01000005_gene1020	5.04e-56	179.0	COG2172@1|root,COG2172@2|Bacteria,1V6V2@1239|Firmicutes,24JPT@186801|Clostridia,3WJC6@541000|Ruminococcaceae	186801|Clostridia	T	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition	spoIIAB	-	2.7.11.1	ko:K06379	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c_2
PKFBICOC_00430	445972.ANACOL_01712	1.16e-22	92.0	COG1366@1|root,COG1366@2|Bacteria,1VENG@1239|Firmicutes,24R0X@186801|Clostridia,3WKRQ@541000|Ruminococcaceae	186801|Clostridia	T	Belongs to the anti-sigma-factor antagonist family	spoIIAA	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS
PKFBICOC_00431	1121334.KB911066_gene768	1.99e-133	398.0	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,3WGH0@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
PKFBICOC_00432	1120746.CCNL01000017_gene3223	2.74e-130	377.0	COG0313@1|root,COG0313@2|Bacteria,2NP98@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
PKFBICOC_00433	411473.RUMCAL_01800	2.97e-52	176.0	COG4123@1|root,COG4123@2|Bacteria,1TQ25@1239|Firmicutes,24J47@186801|Clostridia,3WRTS@541000|Ruminococcaceae	186801|Clostridia	S	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	MTS
PKFBICOC_00434	645991.Sgly_0634	5.05e-11	58.5	COG4231@1|root,COG4231@2|Bacteria,1UIUE@1239|Firmicutes,25ES8@186801|Clostridia,267EQ@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
PKFBICOC_00435	428125.CLOLEP_03761	2.8e-148	424.0	COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,247Q6@186801|Clostridia,3WHA4@541000|Ruminococcaceae	186801|Clostridia	S	PSP1 C-terminal domain protein	yaaT	-	-	-	-	-	-	-	-	-	-	-	PSP1
PKFBICOC_00436	1111732.AZOD01000005_gene866	5.88e-05	52.4	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1X34V@135614|Xanthomonadales	135614|Xanthomonadales	L	the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
PKFBICOC_00437	1121423.JONT01000001_gene1864	6.44e-24	98.2	COG0622@1|root,COG0622@2|Bacteria,1VA0U@1239|Firmicutes,24MMK@186801|Clostridia,262XS@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM phosphodiesterase, MJ0936	yfcE1	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
PKFBICOC_00439	428125.CLOLEP_01049	3.38e-12	66.6	2EH2J@1|root,33AUH@2|Bacteria,1VP6D@1239|Firmicutes,24QT3@186801|Clostridia,3WM9M@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00441	1120746.CCNL01000017_gene3264	7.04e-193	547.0	COG0014@1|root,COG0014@2|Bacteria,2NQM3@2323|unclassified Bacteria	2|Bacteria	E	Aldehyde dehydrogenase family	proA	GO:0003674,GO:0003824,GO:0004350,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iB21_1397.B21_00243,iECBD_1354.ECBD_3376,iECB_1328.ECB_00240,iECD_1391.ECD_00240,iLJ478.TM0293,iYL1228.KPN_00280,iYO844.BSU13130	Aldedh
PKFBICOC_00442	428125.CLOLEP_01053	1.66e-118	347.0	COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia,3WGZ7@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
PKFBICOC_00443	428125.CLOLEP_02491	2.49e-159	453.0	COG1897@1|root,COG1897@2|Bacteria,1TQVR@1239|Firmicutes,247NP@186801|Clostridia,3WGY0@541000|Ruminococcaceae	186801|Clostridia	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metAA	-	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS11970	AA_kinase,HTS
PKFBICOC_00445	592027.CLG_B0490	1.45e-258	719.0	COG0441@1|root,COG0441@2|Bacteria,1UHT4@1239|Firmicutes,25E98@186801|Clostridia,36UJY@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
PKFBICOC_00446	96561.Dole_2083	4.75e-15	70.1	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,42V9M@68525|delta/epsilon subdivisions,2WRDW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
PKFBICOC_00447	428125.CLOLEP_03750	1.38e-97	295.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,3WGF4@541000|Ruminococcaceae	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI,Shikimate_DH,Shikimate_dh_N
PKFBICOC_00448	118163.Ple7327_1447	1.59e-28	111.0	COG0703@1|root,COG0703@2|Bacteria,1G5QW@1117|Cyanobacteria,3VJSF@52604|Pleurocapsales	1117|Cyanobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
PKFBICOC_00449	428125.CLOLEP_03746	3.3e-186	524.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,3WG9J@541000|Ruminococcaceae	186801|Clostridia	E	synthase	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS14395	DAHP_synth_1
PKFBICOC_00450	428125.CLOLEP_03745	4.58e-120	351.0	COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia,3WI06@541000|Ruminococcaceae	186801|Clostridia	E	prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
PKFBICOC_00451	537013.CLOSTMETH_02791	4.02e-122	362.0	COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia,3WGPK@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
PKFBICOC_00452	1120746.CCNL01000017_gene3029	1.8e-147	432.0	COG0128@1|root,COG0128@2|Bacteria,2NNZ5@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
PKFBICOC_00453	428125.CLOLEP_03741	3.89e-153	442.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,3WG94@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
PKFBICOC_00454	428125.CLOLEP_03740	4.54e-128	380.0	COG0077@1|root,COG0077@2|Bacteria,1TPDN@1239|Firmicutes,248G7@186801|Clostridia,3WI13@541000|Ruminococcaceae	186801|Clostridia	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
PKFBICOC_00455	1280676.AUJO01000002_gene1682	3.73e-211	602.0	COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,4BW9U@830|Butyrivibrio	186801|Clostridia	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K01176,ko:K05343	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459
PKFBICOC_00457	1378168.N510_01349	1.61e-19	80.1	2EJ02@1|root,33CR7@2|Bacteria,1VPEQ@1239|Firmicutes	1239|Firmicutes	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Arc
PKFBICOC_00458	877414.ATWA01000045_gene1862	8.77e-48	155.0	COG0758@1|root,COG0758@2|Bacteria	2|Bacteria	LU	DNA mediated transformation	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A,DUF2493,MoCo_carrier
PKFBICOC_00460	428125.CLOLEP_02484	0.0	1298.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,3WHFT@541000|Ruminococcaceae	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
PKFBICOC_00461	1235792.C808_02438	4.3e-233	644.0	COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,2493N@186801|Clostridia,27TH1@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Glucose dehydrogenase C-terminus	-	-	1.1.1.103,1.1.1.14	ko:K00008,ko:K00060	ko00040,ko00051,ko00260,ko01100,map00040,map00051,map00260,map01100	M00014	R00875,R01465,R01896	RC00085,RC00102,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
PKFBICOC_00462	1232447.BAHW02000009_gene333	3.56e-142	404.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,268XI@186813|unclassified Clostridiales	186801|Clostridia	G	Ribulose-phosphate 3 epimerase family	-	-	5.1.3.1	ko:K01783,ko:K17195	ko00030,ko00040,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529,R09031	RC00540,RC03111	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
PKFBICOC_00463	1235792.C808_02440	5.08e-268	741.0	COG2271@1|root,COG2271@2|Bacteria,1UHSG@1239|Firmicutes,249UT@186801|Clostridia,27RBF@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Sugar (and other) transporter	-	-	-	ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	MFS_1,Sugar_tr
PKFBICOC_00464	1232453.BAIF02000087_gene258	6.03e-216	600.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24FHS@186801|Clostridia	186801|Clostridia	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
PKFBICOC_00465	1232447.BAHW02000009_gene336	1.1e-191	533.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,268GH@186813|unclassified Clostridiales	186801|Clostridia	G	Fructose-bisphosphate aldolase class-II	-	-	-	-	-	-	-	-	-	-	-	-	F_bP_aldolase
PKFBICOC_00466	411460.RUMTOR_00803	2.47e-159	454.0	COG0524@1|root,COG0524@2|Bacteria,1UYF8@1239|Firmicutes,25MKN@186801|Clostridia,3Y0ZH@572511|Blautia	186801|Clostridia	G	Phosphomethylpyrimidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
PKFBICOC_00467	411460.RUMTOR_00802	4.37e-219	606.0	COG0667@1|root,COG0667@2|Bacteria,1TPIY@1239|Firmicutes,24AVD@186801|Clostridia,3XZZ3@572511|Blautia	186801|Clostridia	C	Aldo/keto reductase family	-	-	-	ko:K18471	ko00640,map00640	-	R10718	RC00739	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
PKFBICOC_00468	537013.CLOSTMETH_03415	9.37e-68	217.0	COG1349@1|root,COG1349@2|Bacteria,1UZ6T@1239|Firmicutes,24B16@186801|Clostridia,3WPVF@541000|Ruminococcaceae	186801|Clostridia	K	transcriptional regulator DeoR family	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
PKFBICOC_00469	1235792.C808_02449	1.23e-238	666.0	COG1301@1|root,COG1301@2|Bacteria,1TPME@1239|Firmicutes,247UX@186801|Clostridia,27JSN@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Sodium:dicarboxylate symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
PKFBICOC_00470	1160721.RBI_I00653	8.01e-216	602.0	COG0371@1|root,COG0371@2|Bacteria,1TQFU@1239|Firmicutes,248KH@186801|Clostridia,3WMZC@541000|Ruminococcaceae	186801|Clostridia	C	Iron-containing alcohol dehydrogenase	gldA	-	1.1.1.6	ko:K00005	ko00561,ko00640,ko01100,map00561,map00640,map01100	-	R01034,R10715,R10717	RC00029,RC00117,RC00670	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
PKFBICOC_00471	1519439.JPJG01000055_gene2199	3.68e-265	744.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,2N6Y1@216572|Oscillospiraceae	186801|Clostridia	F	Adenine deaminase C-terminal domain	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
PKFBICOC_00473	1385512.N784_13830	1.69e-25	108.0	28KBJ@1|root,2Z9YJ@2|Bacteria,1V10F@1239|Firmicutes,4HDQW@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00476	1235799.C818_01939	1.31e-91	274.0	COG1131@1|root,COG1131@2|Bacteria,1V1P4@1239|Firmicutes,249VI@186801|Clostridia,27K3J@186928|unclassified Lachnospiraceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PKFBICOC_00478	742738.HMPREF9460_03543	1.21e-31	120.0	28MKK@1|root,2ZAWR@2|Bacteria,1UYAT@1239|Firmicutes,24GI2@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Viral_Rep
PKFBICOC_00479	1507.HMPREF0262_00034	2.41e-37	129.0	2C5R4@1|root,2ZC1N@2|Bacteria,1V292@1239|Firmicutes,24IHH@186801|Clostridia,36J4J@31979|Clostridiaceae	186801|Clostridia	S	Transposon-encoded protein TnpV	-	-	-	-	-	-	-	-	-	-	-	-	TnpV
PKFBICOC_00480	1161902.HMPREF0378_0101	1.18e-218	617.0	COG3550@1|root,COG3620@1|root,COG3550@2|Bacteria,COG3620@2|Bacteria,1TPEC@1239|Firmicutes,24DHI@186801|Clostridia	186801|Clostridia	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00482	511680.BUTYVIB_01124	9.89e-138	390.0	COG5340@1|root,COG5340@2|Bacteria,1TQSK@1239|Firmicutes,247JC@186801|Clostridia,4C065@830|Butyrivibrio	186801|Clostridia	K	Psort location Cytoplasmic, score	abiGI	-	-	-	-	-	-	-	-	-	-	-	AbiEi_4
PKFBICOC_00483	796945.HMPREF1145_1670	1.22e-171	484.0	COG2253@1|root,COG2253@2|Bacteria,1TT98@1239|Firmicutes,25CI9@186801|Clostridia,2PTZ7@265975|Oribacterium	186801|Clostridia	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
PKFBICOC_00484	1160721.RBI_II00414	0.0	1119.0	COG0286@1|root,COG0286@2|Bacteria,1USEH@1239|Firmicutes,24BYM@186801|Clostridia	186801|Clostridia	V	type II restriction modification enzyme methyltransferase K00571	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
PKFBICOC_00485	746697.Aeqsu_2308	4.78e-161	462.0	COG0286@1|root,COG0286@2|Bacteria,4PP04@976|Bacteroidetes,1IKCU@117743|Flavobacteriia	976|Bacteroidetes	L	Type I restriction modification DNA specificity domain	-	-	-	-	-	-	-	-	-	-	-	-	Methylase_S
PKFBICOC_00486	411459.RUMOBE_00677	1.75e-200	573.0	COG5635@1|root,COG5635@2|Bacteria,1TVV2@1239|Firmicutes,25MSE@186801|Clostridia,3Y1YV@572511|Blautia	186801|Clostridia	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00487	1235799.C818_01369	3.75e-14	69.3	2C5R4@1|root,2ZBQ6@2|Bacteria,1V1T6@1239|Firmicutes,25CQN@186801|Clostridia,27TQE@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Transposon-encoded protein TnpV	-	-	-	-	-	-	-	-	-	-	-	-	TnpV
PKFBICOC_00488	1123250.KB908379_gene1092	7.89e-65	207.0	COG0582@1|root,COG0582@2|Bacteria,1V7JF@1239|Firmicutes,4H4XA@909932|Negativicutes	909932|Negativicutes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
PKFBICOC_00489	469604.HMPREF0946_01125	1.4e-07	53.1	COG0582@1|root,COG0582@2|Bacteria,379GZ@32066|Fusobacteria	32066|Fusobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
PKFBICOC_00490	500632.CLONEX_00837	7.58e-16	71.2	2E5UB@1|root,330IM@2|Bacteria,1VFEC@1239|Firmicutes,24R3P@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00491	566552.BIFCAT_00993	1.06e-27	100.0	COG1396@1|root,COG1396@2|Bacteria,2GPYV@201174|Actinobacteria,4D18X@85004|Bifidobacteriales	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00492	97139.C824_00006	2.48e-23	94.7	28NID@1|root,2ZBJU@2|Bacteria,1V1MS@1239|Firmicutes,24IQU@186801|Clostridia,36K6D@31979|Clostridiaceae	186801|Clostridia	S	Cysteine-rich VLP	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_VLP
PKFBICOC_00494	478749.BRYFOR_08678	3.09e-05	49.3	COG0468@1|root,COG0468@2|Bacteria,1V9SB@1239|Firmicutes,25E2S@186801|Clostridia	186801|Clostridia	L	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	AAA_25
PKFBICOC_00495	1321372.AQQB01000003_gene1497	4.28e-20	85.5	2CDK1@1|root,32G0D@2|Bacteria,1V6YH@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MobC
PKFBICOC_00496	1507.HMPREF0262_00054	3.08e-94	287.0	COG1475@1|root,COG1475@2|Bacteria,1TR7C@1239|Firmicutes,247TW@186801|Clostridia,36HAM@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the ParB family	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
PKFBICOC_00497	861530.ALOZ01000072_gene1848	0.000893	40.4	2A1SG@1|root,30Q14@2|Bacteria,1TY6Z@1239|Firmicutes,4I7A7@91061|Bacilli,4H08N@90964|Staphylococcaceae	91061|Bacilli	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
PKFBICOC_00498	935837.JAEK01000030_gene2720	0.000143	46.6	COG1910@1|root,COG1910@2|Bacteria,1TRH3@1239|Firmicutes,4HAJV@91061|Bacilli,1ZC11@1386|Bacillus	91061|Bacilli	P	COG1910 Periplasmic molybdate-binding protein domain	yvgK	-	-	ko:K07219	-	-	-	-	ko00000	-	-	-	HTH_17,HTH_3,PBP_like
PKFBICOC_00499	641112.ACOK01000115_gene2264	1.25e-08	53.1	COG3311@1|root,COG3311@2|Bacteria,1VKNA@1239|Firmicutes	1239|Firmicutes	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
PKFBICOC_00500	1045004.OKIT_0929	1.17e-29	126.0	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,4HDG6@91061|Bacilli,4AWJ3@81850|Leuconostocaceae	91061|Bacilli	L	Belongs to the 'phage' integrase family	sip	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
PKFBICOC_00501	742738.HMPREF9460_01405	1.58e-161	477.0	COG1961@1|root,COG1961@2|Bacteria,1TPBH@1239|Firmicutes,25B5K@186801|Clostridia,26AKE@186813|unclassified Clostridiales	186801|Clostridia	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
PKFBICOC_00502	428125.CLOLEP_03016	4.14e-99	291.0	COG1961@1|root,COG1961@2|Bacteria,1UZ76@1239|Firmicutes,24G2D@186801|Clostridia	186801|Clostridia	L	resolvase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_7,Resolvase
PKFBICOC_00504	1077285.AGDG01000039_gene3997	1.06e-14	73.6	COG4640@1|root,COG4640@2|Bacteria,4PIJG@976|Bacteroidetes,2FTJN@200643|Bacteroidia,4ATWX@815|Bacteroidaceae	976|Bacteroidetes	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
PKFBICOC_00506	1169144.KB910924_gene359	2.42e-08	56.2	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,4HRBT@91061|Bacilli,1ZISZ@1386|Bacillus	91061|Bacilli	K	Helix-turn-helix XRE-family like proteins	xre	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
PKFBICOC_00508	1294265.JCM21738_732	5.44e-109	359.0	COG1241@1|root,COG3378@1|root,COG1241@2|Bacteria,COG3378@2|Bacteria,1UFMD@1239|Firmicutes,4IEUR@91061|Bacilli,1ZMIK@1386|Bacillus	91061|Bacilli	L	Phage plasmid primase P4 family	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00510	500632.CLONEX_00758	9.74e-17	73.2	2DPYU@1|root,33404@2|Bacteria,1VEMP@1239|Firmicutes,24UUX@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00511	469596.HMPREF9488_02215	1.33e-139	400.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,3VPAB@526524|Erysipelotrichia	526524|Erysipelotrichia	D	CobQ CobB MinD ParA nucleotide binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
PKFBICOC_00512	1321372.AQQB01000003_gene1485	2.06e-155	444.0	COG1475@1|root,COG1475@2|Bacteria,1TR7C@1239|Firmicutes,4IJ2M@91061|Bacilli,1WTIK@1307|Streptococcus suis	91061|Bacilli	K	ParB-like nuclease domain	parB_1	-	-	-	-	-	-	-	-	-	-	-	ParBc
PKFBICOC_00513	1408437.JNJN01000042_gene780	0.0	1511.0	COG4932@1|root,COG4932@2|Bacteria,1TRG6@1239|Firmicutes,2492K@186801|Clostridia,25VZ7@186806|Eubacteriaceae	186801|Clostridia	M	Cna protein B-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Sortase
PKFBICOC_00515	1321372.AQQB01000003_gene1490	6.29e-19	80.1	2C6KJ@1|root,33B28@2|Bacteria,1VKZ3@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00517	665956.HMPREF1032_02552	5.5e-86	268.0	2DBK7@1|root,2Z9RA@2|Bacteria,1UC8U@1239|Firmicutes,24EYV@186801|Clostridia,3WJ2J@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4313
PKFBICOC_00518	469596.HMPREF9488_02220	0.0	2591.0	COG0553@1|root,COG0827@1|root,COG4646@1|root,COG0553@2|Bacteria,COG0827@2|Bacteria,COG4646@2|Bacteria,1TPQA@1239|Firmicutes,3VNX4@526524|Erysipelotrichia	526524|Erysipelotrichia	L	Helicase C-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
PKFBICOC_00519	1226325.HMPREF1548_01694	0.0	1266.0	COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia,36DU1@31979|Clostridiaceae	186801|Clostridia	L	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	DUF4368,Recombinase,Resolvase,Zn_ribbon_recom
PKFBICOC_00520	1226325.HMPREF1548_01692	4.09e-221	610.0	COG1686@1|root,COG1686@2|Bacteria,1UYI0@1239|Firmicutes,24A51@186801|Clostridia	186801|Clostridia	M	serine-type D-Ala-D-Ala carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S11
PKFBICOC_00521	1226325.HMPREF1548_01690	6.98e-241	662.0	COG3598@1|root,COG3598@2|Bacteria,1UIBK@1239|Firmicutes,24K1Q@186801|Clostridia,36UQ1@31979|Clostridiaceae	186801|Clostridia	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_25,Prim-Pol
PKFBICOC_00524	397290.C810_03653	3.07e-257	722.0	COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia,27J4S@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Domain of unknown function (DUF4368)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4368,Recombinase,Resolvase,Zn_ribbon_recom
PKFBICOC_00526	479437.Elen_2186	3.28e-75	241.0	COG2755@1|root,COG2755@2|Bacteria,2HUFA@201174|Actinobacteria,4CUEM@84998|Coriobacteriia	84998|Coriobacteriia	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00527	1123313.ATUT01000031_gene1457	9.18e-184	533.0	COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,3VP7P@526524|Erysipelotrichia	526524|Erysipelotrichia	M	MBOAT, membrane-bound O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
PKFBICOC_00528	883114.HMPREF9709_01432	1.86e-30	108.0	COG0236@1|root,COG0236@2|Bacteria,1VEX6@1239|Firmicutes,24QWP@186801|Clostridia	186801|Clostridia	IQ	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
PKFBICOC_00529	700015.Corgl_0446	5.8e-112	340.0	COG0019@1|root,COG0019@2|Bacteria,2GIT5@201174|Actinobacteria,4CUJG@84998|Coriobacteriia	84998|Coriobacteriia	E	Pyridoxal-dependent decarboxylase, C-terminal sheet domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
PKFBICOC_00530	883114.HMPREF9709_01434	4.36e-202	578.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,22GKH@1570339|Peptoniphilaceae	186801|Clostridia	Q	AMP-binding enzyme	-	-	6.1.1.13	ko:K03367,ko:K04784	ko00473,ko01053,ko01503,ko02020,ko05150,map00473,map01053,map01503,map02020,map05150	M00725	R02718	RC00037,RC00094	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008,ko01504	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
PKFBICOC_00531	1540257.JQMW01000009_gene2929	1.5e-24	114.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36DKF@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
PKFBICOC_00532	525379.HMPREF0819_0942	3.85e-66	211.0	COG0745@1|root,COG0745@2|Bacteria,1TR8K@1239|Firmicutes,4HBSB@91061|Bacilli	91061|Bacilli	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	srrA3	-	-	ko:K07775	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
PKFBICOC_00533	1160721.RBI_II00013	4.52e-74	226.0	2CAVT@1|root,304CC@2|Bacteria,1V4J6@1239|Firmicutes,24HQA@186801|Clostridia,3WK7E@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2798
PKFBICOC_00534	1499685.CCFJ01000046_gene3155	7.49e-15	69.3	2DR1Y@1|root,339TZ@2|Bacteria,1VK7M@1239|Firmicutes,4HR6A@91061|Bacilli,1ZKCJ@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF3006)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3006
PKFBICOC_00535	767817.Desgi_1323	1.28e-80	256.0	COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,2617G@186807|Peptococcaceae	186801|Clostridia	S	PFAM Metallo-beta-lactamase superfamily	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Ada_Zn_binding,LTD,Lactamase_B
PKFBICOC_00536	397290.C810_04095	0.0	892.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,27I9D@186928|unclassified Lachnospiraceae	186801|Clostridia	V	overlaps another CDS with the same product name	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
PKFBICOC_00537	622312.ROSEINA2194_02623	2.42e-266	747.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia	186801|Clostridia	V	Abc transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
PKFBICOC_00538	1400520.LFAB_08920	1.53e-07	55.5	COG1846@1|root,COG1846@2|Bacteria,1TTKD@1239|Firmicutes,4HQ62@91061|Bacilli,3F7T9@33958|Lactobacillaceae	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
PKFBICOC_00540	622312.ROSEINA2194_03846	2.44e-57	194.0	COG1295@1|root,COG1295@2|Bacteria,1U7HM@1239|Firmicutes,24A2Q@186801|Clostridia	186801|Clostridia	H	Belongs to the UPF0761 family	yihY	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
PKFBICOC_00541	1105031.HMPREF1141_0695	8.04e-83	256.0	COG0300@1|root,COG0300@2|Bacteria,1UZHA@1239|Firmicutes,248C8@186801|Clostridia,36IDY@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
PKFBICOC_00542	1384066.JAGT01000001_gene409	1.04e-48	165.0	COG0500@1|root,COG2226@2|Bacteria,1V53X@1239|Firmicutes,24IQW@186801|Clostridia	186801|Clostridia	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1653,Methyltransf_11,Methyltransf_25
PKFBICOC_00544	411463.EUBVEN_00557	2.59e-136	407.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,25UR4@186806|Eubacteriaceae	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
PKFBICOC_00545	428125.CLOLEP_01540	4.48e-225	633.0	COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,2484K@186801|Clostridia,3WGQ1@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
PKFBICOC_00547	903814.ELI_0802	8.01e-18	95.1	COG3290@1|root,COG3290@2|Bacteria,1VC62@1239|Firmicutes,25FKE@186801|Clostridia,25ZJW@186806|Eubacteriaceae	186801|Clostridia	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_5
PKFBICOC_00548	545696.HOLDEFILI_02110	2.04e-17	85.9	COG3279@1|root,COG3279@2|Bacteria,1VC9Q@1239|Firmicutes,3VS40@526524|Erysipelotrichia	526524|Erysipelotrichia	KT	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
PKFBICOC_00549	903814.ELI_2078	1.83e-98	312.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,25UX6@186806|Eubacteriaceae	186801|Clostridia	O	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
PKFBICOC_00551	717606.PaecuDRAFT_3233	1.92e-05	54.7	COG1199@1|root,COG2176@1|root,COG1199@2|Bacteria,COG2176@2|Bacteria,1TQHQ@1239|Firmicutes,4HB2Y@91061|Bacilli,26T6Z@186822|Paenibacillaceae	91061|Bacilli	L	helicase involved in DNA repair and perhaps also replication	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2,RNase_T,ResIII
PKFBICOC_00552	428125.CLOLEP_01573	0.0	991.0	COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,248EB@186801|Clostridia,3WGEU@541000|Ruminococcaceae	186801|Clostridia	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
PKFBICOC_00553	1410617.JHXH01000004_gene1288	0.0	1007.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia,3WG9R@541000|Ruminococcaceae	186801|Clostridia	C	aconitate hydratase	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
PKFBICOC_00554	1160721.RBI_I01385	9.29e-246	680.0	COG0538@1|root,COG0538@2|Bacteria,1TSKB@1239|Firmicutes,247KX@186801|Clostridia,3WGXI@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the isocitrate and isopropylmalate dehydrogenases family	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
PKFBICOC_00555	1105031.HMPREF1141_1654	8.71e-86	259.0	COG2344@1|root,COG2344@2|Bacteria,1TSMR@1239|Firmicutes,247RQ@186801|Clostridia,36EUI@31979|Clostridiaceae	186801|Clostridia	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
PKFBICOC_00556	632245.CLP_2315	6.41e-166	510.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia,36E5I@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	pulA	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3372,PUD
PKFBICOC_00557	657322.FPR_10150	3.88e-169	515.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia,3WGSN@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	pulA	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,PUD
PKFBICOC_00558	457421.CBFG_01177	5.5e-181	518.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,268GV@186813|unclassified Clostridiales	186801|Clostridia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
PKFBICOC_00559	673839.D2J077_9CAUD	8.11e-08	56.2	4QAK6@10239|Viruses,4QUP9@35237|dsDNA viruses  no RNA stage,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae	10699|Siphoviridae	S	peptidoglycan catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00560	742738.HMPREF9460_00778	1.95e-21	89.7	COG3824@1|root,COG3824@2|Bacteria,1VFAZ@1239|Firmicutes,24RK0@186801|Clostridia,2693S@186813|unclassified Clostridiales	186801|Clostridia	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Maf,Zincin_1
PKFBICOC_00561	428125.CLOLEP_03935	5.43e-204	571.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,3WGMV@541000|Ruminococcaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
PKFBICOC_00562	537013.CLOSTMETH_02105	4.39e-169	501.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,3WGFW@541000|Ruminococcaceae	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
PKFBICOC_00563	1121334.KB911066_gene1113	2.81e-74	230.0	COG1739@1|root,COG1739@2|Bacteria,1V6MQ@1239|Firmicutes,248W7@186801|Clostridia,3WIHN@541000|Ruminococcaceae	186801|Clostridia	S	YigZ family	yvyE	-	-	-	-	-	-	-	-	-	-	-	DUF1949,UPF0029
PKFBICOC_00564	1235797.C816_00840	6.21e-39	129.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,2N7PC@216572|Oscillospiraceae	186801|Clostridia	J	Ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
PKFBICOC_00566	1514668.JOOA01000002_gene2989	0.0	1052.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,3WGVM@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
PKFBICOC_00571	180332.JTGN01000001_gene5260	5.85e-188	538.0	COG0534@1|root,COG0534@2|Bacteria,1TP5P@1239|Firmicutes,247PQ@186801|Clostridia	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	MatE
PKFBICOC_00572	397288.C806_00777	1.3e-13	78.2	COG0860@1|root,COG1705@1|root,COG5632@1|root,COG0860@2|Bacteria,COG1705@2|Bacteria,COG5632@2|Bacteria,1V7JY@1239|Firmicutes,24C0T@186801|Clostridia,27M0W@186928|unclassified Lachnospiraceae	186801|Clostridia	NU	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,Amidase_3,CW_7,CW_binding_1,Cu_amine_oxidN1,Glucosaminidase,PG_binding_1
PKFBICOC_00574	633147.Olsu_1195	5.78e-06	47.4	2B2D6@1|root,31UXQ@2|Bacteria,2HWBK@201174|Actinobacteria,4CY7Q@84998|Coriobacteriia	84998|Coriobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00575	1120746.CCNL01000011_gene1768	0.0	1467.0	COG0178@1|root,COG0178@2|Bacteria,2NNT3@2323|unclassified Bacteria	2|Bacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
PKFBICOC_00576	1121334.KB911071_gene2085	4.42e-274	773.0	COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,3WG86@541000|Ruminococcaceae	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
PKFBICOC_00577	386415.NT01CX_1039	1.17e-65	206.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,36HYM@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
PKFBICOC_00578	1158318.ATXC01000002_gene1468	5.01e-62	214.0	COG0037@1|root,COG0037@2|Bacteria,2G41C@200783|Aquificae	200783|Aquificae	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
PKFBICOC_00579	428125.CLOLEP_02597	2.91e-208	589.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,3WH8B@541000|Ruminococcaceae	186801|Clostridia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
PKFBICOC_00580	428125.CLOLEP_02596	1.8e-64	200.0	COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,24MT6@186801|Clostridia,3WJCC@541000|Ruminococcaceae	186801|Clostridia	J	binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
PKFBICOC_00581	1105031.HMPREF1141_0312	8.38e-182	538.0	COG3887@1|root,COG3887@2|Bacteria,1TPGP@1239|Firmicutes,2484R@186801|Clostridia,36E60@31979|Clostridiaceae	186801|Clostridia	T	domain protein	yybT	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
PKFBICOC_00582	428125.CLOLEP_02592	1.53e-300	841.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,3WH9M@541000|Ruminococcaceae	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
PKFBICOC_00583	663278.Ethha_2290	2.36e-68	210.0	COG0328@1|root,COG0328@2|Bacteria,1V4A0@1239|Firmicutes,24FSS@186801|Clostridia,3WISH@541000|Ruminococcaceae	186801|Clostridia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
PKFBICOC_00584	1120746.CCNL01000013_gene2029	1.2e-206	580.0	COG1104@1|root,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
PKFBICOC_00585	1120746.CCNL01000013_gene2030	1.79e-87	258.0	COG0822@1|root,COG0822@2|Bacteria,2NPRS@2323|unclassified Bacteria	2|Bacteria	C	NifU-like N terminal domain	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
PKFBICOC_00586	478749.BRYFOR_06424	1.19e-19	92.4	COG4464@1|root,COG4464@2|Bacteria,1TQ1T@1239|Firmicutes,24JQU@186801|Clostridia	186801|Clostridia	GM	capsular polysaccharide biosynthesis protein	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
PKFBICOC_00587	428125.CLOLEP_02914	7.35e-199	557.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,3WG9H@541000|Ruminococcaceae	186801|Clostridia	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
PKFBICOC_00588	428125.CLOLEP_02913	1.25e-83	254.0	COG0406@1|root,COG0406@2|Bacteria,1V6G1@1239|Firmicutes,24JP4@186801|Clostridia,3WJCY@541000|Ruminococcaceae	186801|Clostridia	G	Psort location Cytoplasmic, score	cobC	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
PKFBICOC_00589	428125.CLOLEP_02912	1.23e-54	181.0	COG1396@1|root,COG1396@2|Bacteria,1V2ZX@1239|Firmicutes,24EC9@186801|Clostridia,3WIEA@541000|Ruminococcaceae	186801|Clostridia	K	Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
PKFBICOC_00590	428125.CLOLEP_02095	1.57e-56	178.0	COG2337@1|root,COG2337@2|Bacteria,1V6DK@1239|Firmicutes,24JE1@186801|Clostridia,3WJE1@541000|Ruminococcaceae	186801|Clostridia	L	Toxic component of a toxin-antitoxin (TA) module	ndoA	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
PKFBICOC_00592	511680.BUTYVIB_02389	2.33e-98	289.0	COG0655@1|root,COG0655@2|Bacteria,1UHW0@1239|Firmicutes,24N5N@186801|Clostridia,4BZ31@830|Butyrivibrio	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
PKFBICOC_00593	679192.HMPREF9013_0827	2.85e-229	643.0	COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,3VP3M@526524|Erysipelotrichia	526524|Erysipelotrichia	P	MgtE intracellular N domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE,MgtE_N
PKFBICOC_00595	411474.COPEUT_01919	1.06e-70	215.0	2DU3D@1|root,32UWH@2|Bacteria,1V6ZJ@1239|Firmicutes,24PSR@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4829
PKFBICOC_00596	1410650.JHWL01000009_gene1895	2.03e-94	280.0	COG2206@1|root,COG2206@2|Bacteria,1UZ46@1239|Firmicutes,25FEK@186801|Clostridia,4BYSY@830|Butyrivibrio	186801|Clostridia	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HDOD
PKFBICOC_00597	1120746.CCNL01000011_gene1801	1.26e-70	233.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2NNR2@2323|unclassified Bacteria	2|Bacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
PKFBICOC_00599	1514668.JOOA01000002_gene1723	7.85e-193	541.0	COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,3WGWV@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
PKFBICOC_00600	1280694.AUJQ01000005_gene1380	0.0	1084.0	COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,3NGHV@46205|Pseudobutyrivibrio	186801|Clostridia	J	B3/4 domain	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
PKFBICOC_00601	445972.ANACOL_03424	9.22e-36	122.0	COG4472@1|root,COG4472@2|Bacteria,1VAC4@1239|Firmicutes,24QVQ@186801|Clostridia,3WJXE@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the UPF0297 family	yrzL	-	-	-	-	-	-	-	-	-	-	-	DUF965
PKFBICOC_00602	1120746.CCNL01000011_gene1810	8.58e-36	124.0	2DG94@1|root,337GI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00603	411471.SUBVAR_07417	6.7e-13	63.5	COG3041@1|root,COG3041@2|Bacteria,1VENE@1239|Firmicutes,24MW1@186801|Clostridia,3WJV4@541000|Ruminococcaceae	186801|Clostridia	S	addiction module toxin, RelE StbE family	-	-	-	ko:K19157	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	YafQ_toxin
PKFBICOC_00604	1321782.HMPREF1986_01587	3.33e-20	84.7	COG3077@1|root,COG3077@2|Bacteria,1VDWV@1239|Firmicutes,24T0S@186801|Clostridia	186801|Clostridia	L	RelB antitoxin	-	-	-	ko:K07473	-	-	-	-	ko00000,ko02048	-	-	-	RelB
PKFBICOC_00605	478749.BRYFOR_08890	0.0	1093.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	actP	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
PKFBICOC_00606	411462.DORLON_02320	1.21e-47	154.0	COG1937@1|root,COG1937@2|Bacteria,1VEF5@1239|Firmicutes,24QRR@186801|Clostridia,27VQM@189330|Dorea	186801|Clostridia	S	Metal-sensitive transcriptional repressor	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
PKFBICOC_00607	936596.HMPREF1495_1676	1.15e-11	62.4	COG3077@1|root,COG3077@2|Bacteria,1VIMK@1239|Firmicutes,25CY2@186801|Clostridia	186801|Clostridia	L	RelB antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	RelB
PKFBICOC_00608	887325.HMPREF0381_0765	1.51e-25	97.8	COG3041@1|root,COG3041@2|Bacteria,1VENE@1239|Firmicutes,24MW1@186801|Clostridia,1HWDT@1164882|Lachnoanaerobaculum	186801|Clostridia	S	Bacterial toxin of type II toxin-antitoxin system, YafQ	-	-	-	ko:K19157	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	YafQ_toxin
PKFBICOC_00609	1120746.CCNL01000010_gene1362	1.23e-36	125.0	COG0238@1|root,COG0238@2|Bacteria,2NQ53@2323|unclassified Bacteria	2|Bacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
PKFBICOC_00610	713605.ADHG01000001_gene405	1.5e-29	112.0	COG0629@1|root,COG0629@2|Bacteria,1V3WT@1239|Firmicutes,4HH8I@91061|Bacilli,3F66N@33958|Lactobacillaceae	91061|Bacilli	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
PKFBICOC_00611	428125.CLOLEP_00519	2.95e-42	140.0	COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,24QZQ@186801|Clostridia,3WK85@541000|Ruminococcaceae	186801|Clostridia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
PKFBICOC_00612	246199.CUS_7705	1.52e-70	220.0	COG0135@1|root,COG0135@2|Bacteria,1V6Y0@1239|Firmicutes,24HBQ@186801|Clostridia,3WM7Q@541000|Ruminococcaceae	186801|Clostridia	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
PKFBICOC_00613	1410674.JNKU01000024_gene1981	2.05e-154	441.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,4HAMU@91061|Bacilli,3F4VD@33958|Lactobacillaceae	91061|Bacilli	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PKFBICOC_00614	1160721.RBI_I00452	2.78e-246	684.0	COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,247XK@186801|Clostridia,3WGNF@541000|Ruminococcaceae	186801|Clostridia	E	O-acetylhomoserine	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
PKFBICOC_00615	246199.CUS_8114	1.8e-59	187.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,3WJN5@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
PKFBICOC_00616	665956.HMPREF1032_01860	1.03e-173	502.0	COG2252@1|root,COG2252@2|Bacteria,1TQC6@1239|Firmicutes,2483Q@186801|Clostridia,3WP2F@541000|Ruminococcaceae	186801|Clostridia	S	Permease family	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
PKFBICOC_00617	445972.ANACOL_00781	1.07e-87	266.0	COG1191@1|root,COG1191@2|Bacteria,1TPJ5@1239|Firmicutes,247XH@186801|Clostridia,3WG7B@541000|Ruminococcaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigK	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
PKFBICOC_00623	1235799.C818_02530	4.77e-252	700.0	COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,27J6E@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Sodium:neurotransmitter symporter family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
PKFBICOC_00624	553973.CLOHYLEM_05329	1.97e-33	122.0	COG1340@1|root,COG1340@2|Bacteria,1V7S0@1239|Firmicutes,24KZW@186801|Clostridia	186801|Clostridia	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
PKFBICOC_00625	1235793.C809_04026	2.26e-80	244.0	COG1180@1|root,COG1180@2|Bacteria,1UK6G@1239|Firmicutes,25FMZ@186801|Clostridia,27UKC@186928|unclassified Lachnospiraceae	186801|Clostridia	O	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
PKFBICOC_00626	1341157.RF007C_09930	3.84e-34	125.0	COG4720@1|root,COG4720@2|Bacteria,1VF2R@1239|Firmicutes,24QR3@186801|Clostridia,3WMJA@541000|Ruminococcaceae	186801|Clostridia	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
PKFBICOC_00627	1232453.BAIF02000002_gene1241	6.03e-94	286.0	COG2240@1|root,COG2240@2|Bacteria,1TRCR@1239|Firmicutes,24ABV@186801|Clostridia,267IY@186813|unclassified Clostridiales	186801|Clostridia	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.35	ko:K00868	ko00750,ko01100,map00750,map01100	-	R00174,R01909,R02493	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	Phos_pyr_kin
PKFBICOC_00628	1511.CLOST_0741	6.65e-32	126.0	28HFF@1|root,2Z7RI@2|Bacteria,1UQFG@1239|Firmicutes,24MHK@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00630	622312.ROSEINA2194_03060	1.58e-47	154.0	COG1917@1|root,COG1917@2|Bacteria,1UK9X@1239|Firmicutes,24P6I@186801|Clostridia	186801|Clostridia	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
PKFBICOC_00631	1235800.C819_00658	8.92e-69	213.0	COG1247@1|root,COG1247@2|Bacteria,1V3XH@1239|Firmicutes,24HCN@186801|Clostridia,27N0Z@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PKFBICOC_00632	428125.CLOLEP_01532	4.71e-219	614.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,3WGI3@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
PKFBICOC_00633	1160721.RBI_I01660	9.08e-67	204.0	COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,24J8Y@186801|Clostridia,3WJG0@541000|Ruminococcaceae	186801|Clostridia	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
PKFBICOC_00634	411473.RUMCAL_00117	3.27e-211	592.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,3WH1M@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
PKFBICOC_00635	411467.BACCAP_01256	2.26e-65	204.0	COG0716@1|root,COG0716@2|Bacteria,1V6D7@1239|Firmicutes,24J7W@186801|Clostridia,269HS@186813|unclassified Clostridiales	186801|Clostridia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1
PKFBICOC_00636	1336241.JAEB01000011_gene2108	8.34e-66	206.0	2BYWB@1|root,32SGE@2|Bacteria,1V4H1@1239|Firmicutes,25CVU@186801|Clostridia,25ZJB@186806|Eubacteriaceae	186801|Clostridia	S	Protein of unknown function (DUF3793)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3793
PKFBICOC_00637	1268072.PSAB_06350	5.64e-10	68.6	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V13G@1239|Firmicutes,4I9SE@91061|Bacilli,271XK@186822|Paenibacillaceae	91061|Bacilli	T	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
PKFBICOC_00638	742735.HMPREF9467_02854	1.18e-35	125.0	COG2608@1|root,COG2608@2|Bacteria,1VEMB@1239|Firmicutes,24REK@186801|Clostridia,220T7@1506553|Lachnoclostridium	186801|Clostridia	P	Heavy-metal-associated domain	-	-	-	-	-	-	-	-	-	-	-	-	HMA,P12
PKFBICOC_00640	1160721.RBI_I00823	0.0	1239.0	COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,3WGIX@541000|Ruminococcaceae	186801|Clostridia	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
PKFBICOC_00641	748224.HMPREF9436_02504	6.41e-37	125.0	COG1918@1|root,COG1918@2|Bacteria,1VEHC@1239|Firmicutes,24QKE@186801|Clostridia,3WKEJ@541000|Ruminococcaceae	186801|Clostridia	P	Fe2 transport system protein A	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
PKFBICOC_00642	693746.OBV_37940	1.1e-29	106.0	COG1918@1|root,COG1918@2|Bacteria,1VEYA@1239|Firmicutes,24QKX@186801|Clostridia,2N7Q6@216572|Oscillospiraceae	186801|Clostridia	P	FeoA	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
PKFBICOC_00643	1378168.N510_01416	2.51e-37	130.0	COG1321@1|root,COG1321@2|Bacteria,1V3IS@1239|Firmicutes	1239|Firmicutes	K	Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon	mntR_1	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repr_C,Fe_dep_repress
PKFBICOC_00644	1121289.JHVL01000064_gene299	1.21e-20	90.1	2ED9K@1|root,33761@2|Bacteria,1VEHV@1239|Firmicutes,24S9B@186801|Clostridia,36MUZ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00645	537013.CLOSTMETH_02184	1.65e-94	280.0	COG1073@1|root,COG1073@2|Bacteria,1U9AI@1239|Firmicutes,24B6Z@186801|Clostridia,3WHN9@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
PKFBICOC_00646	1120746.CCNL01000017_gene3231	0.0	915.0	COG2183@1|root,COG2183@2|Bacteria,2NP2S@2323|unclassified Bacteria	2|Bacteria	K	Tex-like protein N-terminal domain	yhgF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
PKFBICOC_00647	97139.C824_05257	4.63e-102	306.0	COG2116@1|root,COG2116@2|Bacteria,1TRTT@1239|Firmicutes,24BU5@186801|Clostridia,36F4N@31979|Clostridiaceae	186801|Clostridia	P	Formate nitrite	fnt	-	-	ko:K21993	-	-	-	-	ko00000,ko02000	1.A.16.2	-	-	Form_Nir_trans
PKFBICOC_00648	411471.SUBVAR_05881	3.38e-43	152.0	COG3859@1|root,COG3859@2|Bacteria,1V1WX@1239|Firmicutes,24JF9@186801|Clostridia,3WJRT@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K16789	-	-	-	-	ko00000,ko02000	2.A.88.3	-	-	Thia_YuaJ
PKFBICOC_00649	411470.RUMGNA_03224	3.2e-08	51.6	2EHCX@1|root,33B4S@2|Bacteria,1VKA0@1239|Firmicutes	1239|Firmicutes	S	Spore coat associated protein JA (CotJA)	-	-	-	-	-	-	-	-	-	-	-	-	CotJA
PKFBICOC_00650	272563.CD630_05970	1.87e-12	64.3	2E34J@1|root,32Y4N@2|Bacteria,1VESM@1239|Firmicutes,24QZX@186801|Clostridia	186801|Clostridia	S	COG NOG18028 non supervised orthologous group	cotJB	-	-	ko:K06333	-	-	-	-	ko00000	-	-	-	CotJB
PKFBICOC_00651	1121335.Clst_2046	3.66e-08	50.8	COG3546@1|root,COG3546@2|Bacteria	2|Bacteria	P	catalase activity	cotJC	-	-	ko:K06334,ko:K07217	-	-	-	-	ko00000	-	-	-	Mn_catalase
PKFBICOC_00652	457412.RSAG_02474	2.62e-140	404.0	COG0583@1|root,COG0583@2|Bacteria,1TRYW@1239|Firmicutes,249AX@186801|Clostridia,3WJR3@541000|Ruminococcaceae	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
PKFBICOC_00653	457412.RSAG_02475	2.87e-277	763.0	COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,3WHBC@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
PKFBICOC_00654	1410630.JNKP01000004_gene255	2.31e-10	60.1	COG0454@1|root,COG0456@2|Bacteria,1V77V@1239|Firmicutes,24MDJ@186801|Clostridia,27MDF@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PKFBICOC_00655	633697.EubceDRAFT1_1287	5.34e-111	332.0	COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,249SF@186801|Clostridia,25V8W@186806|Eubacteriaceae	186801|Clostridia	E	Psort location Cytoplasmic, score	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
PKFBICOC_00656	537013.CLOSTMETH_00694	1.16e-62	199.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia,3WJIZ@541000|Ruminococcaceae	186801|Clostridia	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
PKFBICOC_00657	411463.EUBVEN_00590	8.73e-144	423.0	COG0523@1|root,COG0523@2|Bacteria,1TPCG@1239|Firmicutes,248XD@186801|Clostridia,25VUJ@186806|Eubacteriaceae	186801|Clostridia	S	CobW P47K family protein	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
PKFBICOC_00659	97139.C824_02520	9.59e-111	327.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia,36E89@31979|Clostridiaceae	186801|Clostridia	E	ABC transporter	glnQ	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
PKFBICOC_00660	1121344.JHZO01000001_gene519	3.2e-82	251.0	COG0765@1|root,COG0765@2|Bacteria,1V280@1239|Firmicutes,25C2S@186801|Clostridia,3WHKU@541000|Ruminococcaceae	186801|Clostridia	P	ABC transporter, permease protein	tcyB	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
PKFBICOC_00661	411469.EUBHAL_00834	5.95e-73	232.0	COG0834@1|root,COG0834@2|Bacteria,1TQNR@1239|Firmicutes,249Y5@186801|Clostridia,25VIV@186806|Eubacteriaceae	186801|Clostridia	ET	ABC transporter, substrate-binding protein, family 3	fliY1	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
PKFBICOC_00662	1519439.JPJG01000060_gene1861	1.16e-94	299.0	COG1961@1|root,COG1961@2|Bacteria,1TPBH@1239|Firmicutes,25B5K@186801|Clostridia,2N6BB@216572|Oscillospiraceae	186801|Clostridia	L	Resolvase, N terminal domain	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
PKFBICOC_00663	1121334.KB911080_gene1244	2.04e-78	238.0	COG3546@1|root,COG3546@2|Bacteria,1TQVQ@1239|Firmicutes,247YJ@186801|Clostridia,3WHS3@541000|Ruminococcaceae	186801|Clostridia	P	PFAM Manganese containing catalase	cotJC	-	-	ko:K06334	-	-	-	-	ko00000	-	-	-	Mn_catalase
PKFBICOC_00664	1410653.JHVC01000002_gene4516	7.12e-30	121.0	COG3475@1|root,COG3475@2|Bacteria,1VBSV@1239|Firmicutes,24C5H@186801|Clostridia,36EWJ@31979|Clostridiaceae	186801|Clostridia	M	LICD family	licD	-	-	ko:K07271	-	-	-	-	ko00000,ko01000	-	-	-	LicD
PKFBICOC_00665	272559.BF9343_2708	7.62e-26	112.0	COG1215@1|root,COG1215@2|Bacteria,4NKV9@976|Bacteroidetes,2G04J@200643|Bacteroidia,4ARE4@815|Bacteroidaceae	976|Bacteroidetes	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PKFBICOC_00666	1280668.ATVT01000008_gene587	3.98e-26	112.0	COG1035@1|root,COG3955@1|root,COG1035@2|Bacteria,COG3955@2|Bacteria,1TQGA@1239|Firmicutes,249BE@186801|Clostridia,4BZCS@830|Butyrivibrio	186801|Clostridia	C	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7,FrhB_FdhB_C,FrhB_FdhB_N
PKFBICOC_00667	1294265.JCM21738_879	2.49e-54	187.0	COG1216@1|root,COG1216@2|Bacteria,1VATJ@1239|Firmicutes,4HCW0@91061|Bacilli,1ZFI5@1386|Bacillus	91061|Bacilli	S	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PKFBICOC_00668	1449342.JQMR01000001_gene86	4.85e-33	133.0	COG3274@1|root,COG3274@2|Bacteria,1V0QX@1239|Firmicutes,4HFH3@91061|Bacilli,27FV5@186828|Carnobacteriaceae	91061|Bacilli	S	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
PKFBICOC_00669	1304284.L21TH_1874	1.6e-113	353.0	COG2244@1|root,COG2244@2|Bacteria,1TQ51@1239|Firmicutes,24DRX@186801|Clostridia,36G90@31979|Clostridiaceae	186801|Clostridia	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
PKFBICOC_00670	411476.BACOVA_05510	1.65e-86	274.0	COG1035@1|root,COG1143@1|root,COG1035@2|Bacteria,COG1143@2|Bacteria,4NG86@976|Bacteroidetes,2FMH7@200643|Bacteroidia,4AQUN@815|Bacteroidaceae	976|Bacteroidetes	C	coenzyme F420-reducing hydrogenase beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7,FrhB_FdhB_C,FrhB_FdhB_N,Hexapep
PKFBICOC_00671	445973.CLOBAR_02315	2.26e-120	361.0	COG2327@1|root,COG2327@2|Bacteria,1UZDY@1239|Firmicutes,24BCV@186801|Clostridia	186801|Clostridia	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
PKFBICOC_00672	411467.BACCAP_01611	2.33e-70	228.0	COG1216@1|root,COG1216@2|Bacteria,1VATJ@1239|Firmicutes,24H9J@186801|Clostridia,268VP@186813|unclassified Clostridiales	186801|Clostridia	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PKFBICOC_00673	411462.DORLON_01611	1.16e-113	339.0	COG0463@1|root,COG0463@2|Bacteria,1VVRP@1239|Firmicutes	1239|Firmicutes	M	Glycosyltransferase group 2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PKFBICOC_00674	1235803.C825_04479	8.96e-138	404.0	COG0438@1|root,COG0438@2|Bacteria,4NJ8R@976|Bacteroidetes,2G2SM@200643|Bacteroidia,230Q6@171551|Porphyromonadaceae	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
PKFBICOC_00675	742722.HMPREF9463_01431	8.62e-46	155.0	COG1045@1|root,COG1045@2|Bacteria,2GQAY@201174|Actinobacteria	201174|Actinobacteria	E	Bacterial transferase hexapeptide (six repeats)	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2
PKFBICOC_00676	411477.PARMER_01961	1.73e-123	362.0	COG0463@1|root,COG0463@2|Bacteria,4NGTD@976|Bacteroidetes,2FPNS@200643|Bacteroidia,22ZF2@171551|Porphyromonadaceae	976|Bacteroidetes	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PKFBICOC_00677	1131730.BAVI_17107	3.62e-110	333.0	COG0438@1|root,COG0438@2|Bacteria,1TRCM@1239|Firmicutes,4HC0S@91061|Bacilli,1ZEMI@1386|Bacillus	91061|Bacilli	M	Glycosyl transferases group 1	-	-	-	ko:K19424	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
PKFBICOC_00679	877420.ATVW01000034_gene1473	1.23e-150	436.0	COG0438@1|root,COG0438@2|Bacteria,1UVD4@1239|Firmicutes,25KG1@186801|Clostridia,27KNU@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glycos_transf_1
PKFBICOC_00680	1095750.HMPREF9970_3027	2.2e-174	493.0	COG2232@1|root,COG2232@2|Bacteria,1TPT6@1239|Firmicutes,24DWY@186801|Clostridia	186801|Clostridia	S	ATP-grasp domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_3,HAD_2
PKFBICOC_00681	1095750.HMPREF9970_3026	1.19e-86	262.0	COG2148@1|root,COG2148@2|Bacteria,1TP49@1239|Firmicutes,249F1@186801|Clostridia,1HWD6@1164882|Lachnoanaerobaculum	186801|Clostridia	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,Glycos_transf_2
PKFBICOC_00682	97139.C824_03239	1.74e-204	575.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,36FSU@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
PKFBICOC_00685	471875.RUMLAC_01578	8.56e-34	117.0	2E7EE@1|root,331XF@2|Bacteria,1VFH0@1239|Firmicutes,24SHY@186801|Clostridia,3WQU7@541000|Ruminococcaceae	186801|Clostridia	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_26
PKFBICOC_00686	1410674.JNKU01000043_gene109	2.81e-69	226.0	28MI8@1|root,2ZAV0@2|Bacteria,1V08P@1239|Firmicutes,4HNC7@91061|Bacilli,3FAU5@33958|Lactobacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00687	1235790.C805_02854	1.78e-148	440.0	COG1196@1|root,COG1196@2|Bacteria,1TS8E@1239|Firmicutes,24YF5@186801|Clostridia	186801|Clostridia	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00689	1410632.JHWW01000005_gene791	2.57e-250	693.0	COG0270@1|root,COG3655@1|root,COG0270@2|Bacteria,COG3655@2|Bacteria,1TSNX@1239|Firmicutes,2490C@186801|Clostridia,27IIV@186928|unclassified Lachnospiraceae	186801|Clostridia	H	C-5 cytosine-specific DNA methylase	haeIIIM	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
PKFBICOC_00690	1410632.JHWW01000005_gene792	7.79e-260	727.0	COG1401@1|root,COG1401@2|Bacteria,1TPIP@1239|Firmicutes,249RD@186801|Clostridia,27K0Q@186928|unclassified Lachnospiraceae	186801|Clostridia	V	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5,EVE
PKFBICOC_00691	1410632.JHWW01000005_gene793	2.64e-198	561.0	2DFWF@1|root,2ZTFK@2|Bacteria	2|Bacteria	S	McrBC 5-methylcytosine restriction system component	-	-	-	ko:K19147	-	-	-	-	ko00000,ko02048	-	-	-	McrBC
PKFBICOC_00692	1235790.C805_00343	8.68e-39	140.0	29HRM@1|root,304NV@2|Bacteria,1V8FB@1239|Firmicutes,25DZR@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF1837)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1837
PKFBICOC_00693	698758.AXY_14020	6.17e-311	863.0	COG2856@1|root,COG2856@2|Bacteria,1TSNE@1239|Firmicutes,4HTDJ@91061|Bacilli	91061|Bacilli	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Peptidase_M78
PKFBICOC_00694	698758.AXY_14010	9.76e-91	280.0	2CAII@1|root,33WU1@2|Bacteria,1VWAP@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00696	1111454.HMPREF1250_1729	2.57e-29	113.0	COG1595@1|root,COG1595@2|Bacteria,1V8TR@1239|Firmicutes	1239|Firmicutes	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF,UPF0122
PKFBICOC_00697	706434.HMPREF9429_01141	3.2e-131	378.0	COG3617@1|root,COG3645@1|root,COG3617@2|Bacteria,COG3645@2|Bacteria,1TPKA@1239|Firmicutes,4H48X@909932|Negativicutes	909932|Negativicutes	K	BRO family, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ANT,Bro-N
PKFBICOC_00698	203119.Cthe_1648	4.4e-49	161.0	2CGYE@1|root,31NJV@2|Bacteria,1V7Z1@1239|Firmicutes,24GBB@186801|Clostridia,3WJFH@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4406
PKFBICOC_00699	767817.Desgi_4526	0.0	1011.0	COG3378@1|root,COG3378@2|Bacteria,1TQP9@1239|Firmicutes,24AY6@186801|Clostridia,265ZW@186807|Peptococcaceae	186801|Clostridia	S	Phage plasmid primase, P4	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	D5_N,Pox_D5,PriCT_1
PKFBICOC_00700	1408311.JNJM01000040_gene945	4.48e-37	127.0	2E38J@1|root,32Y88@2|Bacteria,1VAXK@1239|Firmicutes,24N7K@186801|Clostridia,2PSYA@265975|Oribacterium	186801|Clostridia	S	VRR_NUC	-	-	-	-	-	-	-	-	-	-	-	-	VRR_NUC
PKFBICOC_00701	1118057.CAGX01000043_gene505	1.36e-228	640.0	COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,22GDX@1570339|Peptoniphilaceae	186801|Clostridia	L	snf2 family	-	-	-	-	-	-	-	-	-	-	-	-	SNF2_N
PKFBICOC_00702	203119.Cthe_1732	1.31e-46	154.0	COG1191@1|root,COG1191@2|Bacteria	2|Bacteria	K	sigma factor activity	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	DUF1492,Sigma70_r2,Sigma70_r4
PKFBICOC_00703	1408415.JHXL01000003_gene1144	3.13e-54	172.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HNH
PKFBICOC_00705	1122146.AUHP01000010_gene1049	3.59e-103	301.0	28IR9@1|root,2Z8QS@2|Bacteria,1TV6T@1239|Firmicutes,4HCA9@91061|Bacilli,3F5G5@33958|Lactobacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_4
PKFBICOC_00707	1235802.C823_05288	2.97e-246	682.0	COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1TPHP@1239|Firmicutes,249MR@186801|Clostridia,25VBW@186806|Eubacteriaceae	186801|Clostridia	KL	ParB-like nuclease domain	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase,ParBc
PKFBICOC_00708	1235799.C818_01027	3.89e-313	872.0	COG0270@1|root,COG0270@2|Bacteria,1TR36@1239|Firmicutes,249XY@186801|Clostridia,27JR6@186928|unclassified Lachnospiraceae	186801|Clostridia	L	C-5 cytosine-specific DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	DNA_methylase
PKFBICOC_00709	552396.HMPREF0863_01430	1.76e-32	114.0	COG2105@1|root,COG2105@2|Bacteria,1VGQA@1239|Firmicutes	1239|Firmicutes	S	Domain of unknown function (DUF4314)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4314
PKFBICOC_00710	573061.Clocel_3982	3.91e-187	524.0	28HR1@1|root,2Z7YI@2|Bacteria,1TRNR@1239|Firmicutes,2486X@186801|Clostridia,36DIM@31979|Clostridiaceae	186801|Clostridia	S	amidoligase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Amidoligase_2
PKFBICOC_00711	1121334.KB911068_gene2285	3.39e-80	241.0	COG2105@1|root,COG2105@2|Bacteria,1V56T@1239|Firmicutes,24IPE@186801|Clostridia,3WJQF@541000|Ruminococcaceae	186801|Clostridia	S	Gamma-glutamyl cyclotransferase, AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
PKFBICOC_00712	1235790.C805_01783	1.06e-26	99.0	2EU67@1|root,33MNT@2|Bacteria,1VFUR@1239|Firmicutes,24SZQ@186801|Clostridia,25Z0M@186806|Eubacteriaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00713	1434325.AZQN01000008_gene2856	5.2e-17	85.9	COG1715@1|root,COG1715@2|Bacteria	2|Bacteria	V	Restriction endonuclease	-	-	-	ko:K07448,ko:K07452	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Abi_C,Mrr_N,Mrr_cat,zf-C4_Topoisom
PKFBICOC_00714	243164.DET1088	0.0	972.0	COG4626@1|root,COG4626@2|Bacteria	2|Bacteria	S	Terminase	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_1
PKFBICOC_00715	1235802.C823_05278	2.72e-254	704.0	COG4695@1|root,COG4695@2|Bacteria,1TP8B@1239|Firmicutes,2497C@186801|Clostridia,25VW6@186806|Eubacteriaceae	186801|Clostridia	S	Phage portal protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal
PKFBICOC_00716	573061.Clocel_3976	2.73e-101	301.0	COG0740@1|root,COG0740@2|Bacteria,1TR2H@1239|Firmicutes,249NC@186801|Clostridia,36DUJ@31979|Clostridiaceae	186801|Clostridia	OU	Belongs to the peptidase S14 family	-	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
PKFBICOC_00717	1235802.C823_01519	1.94e-177	507.0	COG4653@1|root,COG4653@2|Bacteria,1TS6A@1239|Firmicutes,24994@186801|Clostridia,25VGC@186806|Eubacteriaceae	186801|Clostridia	S	Phage capsid family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_capsid
PKFBICOC_00718	665950.HMPREF1025_02654	7.98e-54	170.0	2B963@1|root,322H6@2|Bacteria,1V6QQ@1239|Firmicutes,24JTZ@186801|Clostridia	186801|Clostridia	S	phage protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_connect_1
PKFBICOC_00719	665950.HMPREF1025_02655	3.05e-44	146.0	COG5614@1|root,COG5614@2|Bacteria,1V4JY@1239|Firmicutes,24IZC@186801|Clostridia	186801|Clostridia	S	phage head-tail	-	-	-	-	-	-	-	-	-	-	-	-	Phage_H_T_join
PKFBICOC_00720	994573.T472_0210740	6.59e-60	188.0	28PXU@1|root,2ZCHP@2|Bacteria,1V4NB@1239|Firmicutes,24FJY@186801|Clostridia,36IHI@31979|Clostridiaceae	186801|Clostridia	S	TIGRFAM phage protein, HK97 gp10 family	-	-	-	-	-	-	-	-	-	-	-	-	HK97-gp10_like
PKFBICOC_00721	1216932.CM240_1385	2.93e-42	142.0	29CFW@1|root,2ZZE9@2|Bacteria,1V5DV@1239|Firmicutes,24HE3@186801|Clostridia,36KK6@31979|Clostridiaceae	186801|Clostridia	S	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00722	573061.Clocel_3970	3.58e-115	332.0	COG5492@1|root,COG5492@2|Bacteria,1TR3H@1239|Firmicutes,249EK@186801|Clostridia,36G88@31979|Clostridiaceae	186801|Clostridia	N	phage major tail protein, phi13 family	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00723	509191.AEDB02000020_gene3251	5.42e-56	177.0	2AEGM@1|root,314BS@2|Bacteria,1V9FD@1239|Firmicutes,24K8A@186801|Clostridia,3WPBR@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00725	1216932.CM240_0625	6.72e-168	516.0	COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,1TPR1@1239|Firmicutes,24NN1@186801|Clostridia,36F0M@31979|Clostridiaceae	186801|Clostridia	D	tape measure	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00727	1120933.ATUY01000002_gene164	1.66e-18	99.0	COG4926@1|root,COG4926@2|Bacteria,2H2BV@201174|Actinobacteria	201174|Actinobacteria	S	Prophage endopeptidase tail	-	-	-	-	-	-	-	-	-	-	-	-	Prophage_tail
PKFBICOC_00729	1232449.BAHV02000021_gene1073	5.37e-70	213.0	COG4824@1|root,COG4824@2|Bacteria,1V3TR@1239|Firmicutes,24HQ9@186801|Clostridia,269WJ@186813|unclassified Clostridiales	186801|Clostridia	S	Bacteriophage holin family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_4_1
PKFBICOC_00730	411490.ANACAC_00721	3.01e-123	360.0	COG0860@1|root,COG3023@1|root,COG0860@2|Bacteria,COG3023@2|Bacteria,1TRDG@1239|Firmicutes,24ABM@186801|Clostridia	186801|Clostridia	MV	Cpl-7 lysozyme C-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,CW_7,Glucosaminidase,SH3_5,SPOR
PKFBICOC_00731	394503.Ccel_2861	1.03e-21	86.7	2CI33@1|root,3347K@2|Bacteria,1VH48@1239|Firmicutes,24QY1@186801|Clostridia,36MG3@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00732	649747.HMPREF0083_00682	9.99e-19	82.0	2E6I4@1|root,31M4X@2|Bacteria,1VE2X@1239|Firmicutes,4HPIW@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00733	1035184.HMPREF1042_1370	6.89e-205	575.0	COG2887@1|root,COG2887@2|Bacteria,1TPIC@1239|Firmicutes,4HCNN@91061|Bacilli	91061|Bacilli	L	Protein of unknown function (DUF2800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2800
PKFBICOC_00734	748727.CLJU_c03380	4.18e-107	311.0	28J2E@1|root,2Z8YX@2|Bacteria,1TRF9@1239|Firmicutes,249U3@186801|Clostridia,36EHP@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF2815)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2815
PKFBICOC_00736	1118055.CAGU01000013_gene800	0.0	985.0	COG0749@1|root,COG0749@2|Bacteria,1TPTJ@1239|Firmicutes,2487V@186801|Clostridia,22GI8@1570339|Peptoniphilaceae	186801|Clostridia	L	DNA-directed DNA polymerase	-	-	2.7.7.7	ko:K02334	-	-	-	-	ko00000,ko01000	-	-	-	DNA_pol_A
PKFBICOC_00737	397290.C810_01273	3.6e-43	145.0	COG1961@1|root,COG1961@2|Bacteria,1VA99@1239|Firmicutes,24MZH@186801|Clostridia,27NMC@186928|unclassified Lachnospiraceae	186801|Clostridia	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r4_2
PKFBICOC_00738	1235802.C823_06048	7.66e-17	79.7	COG4626@1|root,COG4626@2|Bacteria	2|Bacteria	S	Terminase	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_1
PKFBICOC_00739	658088.HMPREF0987_02702	1.03e-10	59.3	2E6TY@1|root,331DR@2|Bacteria,1VFGY@1239|Firmicutes,24ST4@186801|Clostridia,27QMF@186928|unclassified Lachnospiraceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Tn916-Xis
PKFBICOC_00740	476272.RUMHYD_01496	7.29e-218	611.0	COG0582@1|root,COG0582@2|Bacteria,1TPCB@1239|Firmicutes,2485Y@186801|Clostridia,3XZ4E@572511|Blautia	186801|Clostridia	L	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Integrase_DNA,Phage_integrase
PKFBICOC_00741	246199.CUS_5574	2.33e-258	816.0	COG3188@1|root,COG3188@2|Bacteria,1UJ1B@1239|Firmicutes,25EU6@186801|Clostridia,3WHU7@541000|Ruminococcaceae	186801|Clostridia	NU	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2
PKFBICOC_00744	203119.Cthe_2034	6.98e-182	537.0	COG0515@1|root,COG0515@2|Bacteria,1VT4Y@1239|Firmicutes,24XWW@186801|Clostridia,3WHTE@541000|Ruminococcaceae	186801|Clostridia	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
PKFBICOC_00746	720554.Clocl_0862	1.01e-34	122.0	COG4842@1|root,COG4842@2|Bacteria,1VXZF@1239|Firmicutes,252DA@186801|Clostridia,3WQ09@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the WXG100 family	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00747	720554.Clocl_0861	7.75e-194	562.0	COG1674@1|root,COG1674@2|Bacteria,1VSCH@1239|Firmicutes,24ZW5@186801|Clostridia,3WMY8@541000|Ruminococcaceae	186801|Clostridia	D	FtsK/SpoIIIE family	-	-	-	-	-	-	-	-	-	-	-	-	FtsK_SpoIIIE
PKFBICOC_00748	1341157.RF007C_01900	0.0	1113.0	COG1674@1|root,COG1674@2|Bacteria,1VU03@1239|Firmicutes,24Y4S@186801|Clostridia,3WNJ6@541000|Ruminococcaceae	186801|Clostridia	D	FtsK/SpoIIIE family	-	-	-	-	-	-	-	-	-	-	-	-	FtsK_SpoIIIE
PKFBICOC_00750	720554.Clocl_0858	9.8e-22	89.0	2FFTK@1|root,347QR@2|Bacteria,1VZBJ@1239|Firmicutes,252SP@186801|Clostridia,3WQ3C@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00752	720554.Clocl_0856	1.34e-30	111.0	2CBBN@1|root,34AGF@2|Bacteria,1VYWQ@1239|Firmicutes,2532X@186801|Clostridia,3WQ2E@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00753	411463.EUBVEN_00677	1.26e-114	349.0	COG0457@1|root,COG0457@2|Bacteria,1V1A4@1239|Firmicutes,24BA1@186801|Clostridia	186801|Clostridia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_8
PKFBICOC_00754	411463.EUBVEN_00676	1.09e-25	108.0	COG1372@1|root,COG1372@2|Bacteria,1V120@1239|Firmicutes,24CZG@186801|Clostridia	186801|Clostridia	L	SMART Hedgehog intein hint domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,WHH
PKFBICOC_00756	420246.GTNG_0423	1.63e-35	131.0	COG3209@1|root,COG3209@2|Bacteria,1UKBK@1239|Firmicutes,4ITH1@91061|Bacilli,1WHZC@129337|Geobacillus	91061|Bacilli	M	Pre-toxin TG	-	-	-	-	-	-	-	-	-	-	-	-	PT-TG
PKFBICOC_00760	411902.CLOBOL_04119	5.86e-33	117.0	COG2105@1|root,COG2105@2|Bacteria,1VGQA@1239|Firmicutes,25MCJ@186801|Clostridia,221G7@1506553|Lachnoclostridium	186801|Clostridia	S	Domain of unknown function (DUF4314)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4314
PKFBICOC_00761	697329.Rumal_1386	1.51e-103	311.0	COG0270@1|root,COG0270@2|Bacteria,1TS3G@1239|Firmicutes,249Q9@186801|Clostridia,3WH3U@541000|Ruminococcaceae	186801|Clostridia	H	Psort location Cytoplasmic, score	dcm	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
PKFBICOC_00762	1321778.HMPREF1982_04233	7e-102	308.0	COG0338@1|root,COG0338@2|Bacteria,1UBIY@1239|Firmicutes,248RN@186801|Clostridia,268GE@186813|unclassified Clostridiales	186801|Clostridia	L	D12 class N6 adenine-specific DNA methyltransferase	dam	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
PKFBICOC_00765	742735.HMPREF9467_02757	4.84e-10	60.5	COG2088@1|root,COG2088@2|Bacteria,1V43Z@1239|Firmicutes,24IZB@186801|Clostridia,2233E@1506553|Lachnoclostridium	186801|Clostridia	M	SpoVG	-	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
PKFBICOC_00768	397288.C806_04305	3.05e-83	252.0	COG2105@1|root,COG2105@2|Bacteria,1UY8U@1239|Firmicutes,24BB2@186801|Clostridia,27THB@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00769	999413.HMPREF1094_00600	2.92e-283	849.0	COG4932@1|root,COG4932@2|Bacteria,1TRG6@1239|Firmicutes,3VPYG@526524|Erysipelotrichia	526524|Erysipelotrichia	M	Psort location Cellwall, score	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
PKFBICOC_00770	411490.ANACAC_00754	4.68e-20	86.7	2CGYE@1|root,31NJV@2|Bacteria,1V7Z1@1239|Firmicutes,24GBB@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4406
PKFBICOC_00771	411473.RUMCAL_00224	1.22e-39	135.0	2B05D@1|root,31SFX@2|Bacteria,1V79U@1239|Firmicutes,24KBJ@186801|Clostridia,3WK1Y@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF3852)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3852
PKFBICOC_00772	411473.RUMCAL_00218	4.39e-119	351.0	28I46@1|root,2Z87R@2|Bacteria,1TQ13@1239|Firmicutes,249S3@186801|Clostridia,3WGFY@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00773	1519439.JPJG01000029_gene2293	1.82e-24	95.1	2BXEN@1|root,32R17@2|Bacteria,1V7Y8@1239|Firmicutes,24K6T@186801|Clostridia,2N7RF@216572|Oscillospiraceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00774	411473.RUMCAL_00216	3.98e-63	200.0	28HKG@1|root,2Z7VB@2|Bacteria,1TZFI@1239|Firmicutes,24BXG@186801|Clostridia,3WJN9@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00775	411459.RUMOBE_02253	2.33e-44	157.0	COG4509@1|root,COG4509@2|Bacteria,1V7UG@1239|Firmicutes,24KBR@186801|Clostridia,3Y2BT@572511|Blautia	186801|Clostridia	S	Sortase family	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
PKFBICOC_00776	411473.RUMCAL_00215	0.0	886.0	COG3451@1|root,COG3451@2|Bacteria,1TS2J@1239|Firmicutes,25EI6@186801|Clostridia,3WH1D@541000|Ruminococcaceae	186801|Clostridia	U	Type IV secretory pathway, VirB4 components	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10,DUF87
PKFBICOC_00778	742741.HMPREF9475_01610	1.85e-21	102.0	COG0791@1|root,COG3757@1|root,COG0791@2|Bacteria,COG3757@2|Bacteria,1UK1T@1239|Firmicutes,25FHH@186801|Clostridia,223S9@1506553|Lachnoclostridium	186801|Clostridia	M	Glycosyl hydrolases family 25	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CW_binding_1,Glyco_hydro_25,fn3
PKFBICOC_00779	411489.CLOL250_01214	1.21e-08	54.3	2EA8K@1|root,32VQS@2|Bacteria,1VEBZ@1239|Firmicutes,25D73@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00780	1449050.JNLE01000003_gene1771	2.02e-139	406.0	28HR1@1|root,2Z7YI@2|Bacteria,1TRNR@1239|Firmicutes,2486X@186801|Clostridia,36DIM@31979|Clostridiaceae	186801|Clostridia	S	amidoligase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Amidoligase_2
PKFBICOC_00781	445972.ANACOL_02316	4.71e-66	207.0	COG2105@1|root,COG2105@2|Bacteria,1VDAD@1239|Firmicutes,24G9Y@186801|Clostridia,3WK7N@541000|Ruminococcaceae	186801|Clostridia	S	PFAM AIG2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2,GGACT
PKFBICOC_00784	1226322.HMPREF1545_00379	1.47e-93	296.0	COG0790@1|root,COG0790@2|Bacteria,1TS5X@1239|Firmicutes,248TS@186801|Clostridia,2N6P1@216572|Oscillospiraceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.96	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
PKFBICOC_00785	1449050.JNLE01000005_gene4511	4.04e-38	132.0	2F789@1|root,33ZPI@2|Bacteria,1VXPF@1239|Firmicutes,24TP1@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00786	755731.Clo1100_3503	2.13e-81	262.0	COG0358@1|root,COG0358@2|Bacteria,1TQKP@1239|Firmicutes,247WJ@186801|Clostridia,36FQT@31979|Clostridiaceae	186801|Clostridia	L	Protein of unknown function (DUF3991)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_25,DUF3991,Toprim_2
PKFBICOC_00787	1449126.JQKL01000007_gene676	4.41e-268	755.0	COG3505@1|root,COG3505@2|Bacteria,1TPCF@1239|Firmicutes,2489C@186801|Clostridia,268KX@186813|unclassified Clostridiales	186801|Clostridia	U	TraM recognition site of TraD and TraG	-	-	-	ko:K03205	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	T4SS-DNA_transf
PKFBICOC_00788	431943.CKL_3860	1.21e-26	100.0	COG1846@1|root,COG1846@2|Bacteria,1VAGH@1239|Firmicutes,24N7S@186801|Clostridia,36KHE@31979|Clostridiaceae	186801|Clostridia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_36
PKFBICOC_00789	457412.RSAG_01368	3.6e-51	186.0	COG0642@1|root,COG0642@2|Bacteria,1UICJ@1239|Firmicutes,24NYC@186801|Clostridia	186801|Clostridia	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_5
PKFBICOC_00790	411474.COPEUT_02804	3.17e-37	137.0	COG3279@1|root,COG3279@2|Bacteria,1V140@1239|Firmicutes,24C89@186801|Clostridia	186801|Clostridia	KT	Psort location Cytoplasmic, score	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
PKFBICOC_00791	645991.Sgly_1205	8.38e-25	99.4	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,24JVC@186801|Clostridia,26298@186807|Peptococcaceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
PKFBICOC_00793	411473.RUMCAL_00518	4.25e-11	67.0	COG4512@1|root,COG4512@2|Bacteria,1VJAH@1239|Firmicutes,25BJD@186801|Clostridia	186801|Clostridia	KOT	Psort location CytoplasmicMembrane, score	-	-	-	ko:K07813	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	AgrB
PKFBICOC_00795	1214101.BN159_8020	2.56e-26	108.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	-	2.1.1.45,2.7.4.9	ko:K00560,ko:K00943	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02094,R02098,R02101	RC00002,RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_3363	AAA_33,Thymidylate_kin
PKFBICOC_00797	996637.SGM_4908	9.73e-24	111.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
PKFBICOC_00800	1296415.JACC01000032_gene630	2.91e-65	239.0	COG1020@1|root,COG1020@2|Bacteria,4NDV5@976|Bacteroidetes,1HXHR@117743|Flavobacteriia,2YJ4E@290174|Aquimarina	976|Bacteroidetes	Q	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
PKFBICOC_00801	1501230.ET33_30785	1.01e-15	84.3	2C1YU@1|root,32R9F@2|Bacteria,1VY2Q@1239|Firmicutes,4HT07@91061|Bacilli,276U4@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00802	1123299.AUKZ01000002_gene598	1.64e-125	369.0	COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,4H9NR@91061|Bacilli	91061|Bacilli	S	abc transporter atp-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PKFBICOC_00803	1282665.H353_00985	9.71e-68	218.0	COG4587@1|root,COG4587@2|Bacteria,1TSAN@1239|Firmicutes,4HBVU@91061|Bacilli	91061|Bacilli	S	ABC transporter (permease)	M1-956	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
PKFBICOC_00804	1282665.H353_00980	4.88e-94	284.0	COG3694@1|root,COG3694@2|Bacteria,1US4C@1239|Firmicutes,4IRS2@91061|Bacilli	91061|Bacilli	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
PKFBICOC_00807	357808.RoseRS_0664	2.54e-08	63.5	COG1404@1|root,COG1404@2|Bacteria,2G7HM@200795|Chloroflexi,375CA@32061|Chloroflexia	32061|Chloroflexia	M	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
PKFBICOC_00810	1230342.CTM_17177	5.42e-15	73.6	COG1396@1|root,COG1396@2|Bacteria,1VG62@1239|Firmicutes,24NEA@186801|Clostridia,36KT5@31979|Clostridiaceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31
PKFBICOC_00811	742765.HMPREF9457_01059	4.1e-41	142.0	COG1595@1|root,COG1595@2|Bacteria,1VBST@1239|Firmicutes,259M7@186801|Clostridia,27VYH@189330|Dorea	186801|Clostridia	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r4_2
PKFBICOC_00814	1235797.C816_00571	7.13e-150	447.0	COG1961@1|root,COG1961@2|Bacteria,1TRVQ@1239|Firmicutes,249AZ@186801|Clostridia,2N746@216572|Oscillospiraceae	186801|Clostridia	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
PKFBICOC_00816	180332.JTGN01000003_gene2019	1.19e-139	442.0	COG2932@1|root,COG4694@1|root,COG2932@2|Bacteria,COG4694@2|Bacteria,1TQ19@1239|Firmicutes,25B75@186801|Clostridia	186801|Clostridia	K	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_13
PKFBICOC_00817	931626.Awo_c08830	1.43e-115	365.0	COG0232@1|root,COG0232@2|Bacteria,1TPEI@1239|Firmicutes,247Q1@186801|Clostridia,25VFP@186806|Eubacteriaceae	186801|Clostridia	F	Psort location Cytoplasmic, score	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
PKFBICOC_00819	318161.Sden_2704	1.19e-72	238.0	COG1820@1|root,COG1820@2|Bacteria,1MW8Y@1224|Proteobacteria,1RMRV@1236|Gammaproteobacteria,2QB4P@267890|Shewanellaceae	1236|Gammaproteobacteria	G	TIGRFAM N-acetylglucosamine-6-phosphate deacetylase	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
PKFBICOC_00822	1519439.JPJG01000008_gene1197	6.2e-147	424.0	COG2110@1|root,COG2110@2|Bacteria,1TPCU@1239|Firmicutes,24ARG@186801|Clostridia,2N7GX@216572|Oscillospiraceae	186801|Clostridia	S	Macro domain	-	-	-	-	-	-	-	-	-	-	-	-	Macro
PKFBICOC_00823	1519439.JPJG01000007_gene1206	2.3e-107	314.0	COG2304@1|root,COG2304@2|Bacteria,1TRPP@1239|Firmicutes,249HV@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00824	397291.C804_04364	6.5e-39	154.0	COG5305@1|root,COG5305@2|Bacteria,1UXXF@1239|Firmicutes,25Q2P@186801|Clostridia,27NZC@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
PKFBICOC_00825	1408422.JHYF01000003_gene675	1.89e-37	129.0	COG1695@1|root,COG1695@2|Bacteria,1VAKA@1239|Firmicutes,24MVF@186801|Clostridia,36M0F@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator PadR family	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
PKFBICOC_00829	1235835.C814_01774	1.48e-282	794.0	COG3855@1|root,COG3855@2|Bacteria,1TPFU@1239|Firmicutes,248ZC@186801|Clostridia,3WGTB@541000|Ruminococcaceae	186801|Clostridia	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3	fbp	-	3.1.3.11	ko:K04041	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_2
PKFBICOC_00830	1235797.C816_02297	8.37e-288	805.0	COG0326@1|root,COG0326@2|Bacteria,1TQEU@1239|Firmicutes,247ND@186801|Clostridia,2N70B@216572|Oscillospiraceae	186801|Clostridia	O	Hsp90 protein	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
PKFBICOC_00831	1378168.N510_02309	2.12e-95	317.0	COG1368@1|root,COG1368@2|Bacteria,1TRMA@1239|Firmicutes	1239|Firmicutes	M	Belongs to the LTA synthase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
PKFBICOC_00832	1280681.AUJZ01000004_gene2925	2.07e-13	80.9	COG0810@1|root,COG3210@1|root,COG5279@1|root,COG5492@1|root,COG0810@2|Bacteria,COG3210@2|Bacteria,COG5279@2|Bacteria,COG5492@2|Bacteria,1V4SN@1239|Firmicutes,24HXN@186801|Clostridia,4BXIE@830|Butyrivibrio	186801|Clostridia	DU	Leucine rich repeats (6 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Flg_new,LRR_5,Transglut_core
PKFBICOC_00833	1256908.HMPREF0373_02590	6.87e-32	136.0	COG3209@1|root,COG5279@1|root,COG3209@2|Bacteria,COG5279@2|Bacteria,1V8TE@1239|Firmicutes,24CI3@186801|Clostridia,25XC1@186806|Eubacteriaceae	186801|Clostridia	D	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CW_binding_2,Cu_amine_oxidN1,Transglut_core
PKFBICOC_00834	1297617.JPJD01000034_gene748	2.32e-60	198.0	COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,268T1@186813|unclassified Clostridiales	186801|Clostridia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
PKFBICOC_00835	428125.CLOLEP_00361	5.64e-174	490.0	COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,248CQ@186801|Clostridia,3WGC5@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
PKFBICOC_00836	552398.HMPREF0866_02334	1.06e-51	175.0	COG2323@1|root,COG2323@2|Bacteria,1TRWQ@1239|Firmicutes,24CFP@186801|Clostridia,3WJQE@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
PKFBICOC_00837	357809.Cphy_3785	1.83e-270	764.0	COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,24A10@186801|Clostridia,222FN@1506553|Lachnoclostridium	186801|Clostridia	G	Galactose mutarotase-like	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF5110,Gal_mutarotas_2,Glyco_hydro_31
PKFBICOC_00838	1232446.BAIE02000015_gene1253	1.75e-32	127.0	COG1476@1|root,COG1476@2|Bacteria,1V36C@1239|Firmicutes,24933@186801|Clostridia,26980@186813|unclassified Clostridiales	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
PKFBICOC_00839	428125.CLOLEP_02426	1.04e-246	691.0	COG1109@1|root,COG1109@2|Bacteria,1TS6S@1239|Firmicutes,2491F@186801|Clostridia,3WN8S@541000|Ruminococcaceae	186801|Clostridia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
PKFBICOC_00840	428125.CLOLEP_02423	3.42e-38	129.0	2E6AD@1|root,330Y9@2|Bacteria,1VGZN@1239|Firmicutes,2589N@186801|Clostridia,3WM9E@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00841	718252.FP2_09220	1.69e-18	80.1	2CF79@1|root,32RHV@2|Bacteria,1V7CD@1239|Firmicutes,24QYF@186801|Clostridia,3WMFW@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1292)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1292
PKFBICOC_00843	428125.CLOLEP_02625	1.93e-204	594.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,3WGHX@541000|Ruminococcaceae	186801|Clostridia	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
PKFBICOC_00846	411473.RUMCAL_00474	7.21e-36	124.0	COG1476@1|root,COG1476@2|Bacteria,1VHE1@1239|Firmicutes,24SCN@186801|Clostridia	186801|Clostridia	K	Bacteriophage CI repressor helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
PKFBICOC_00847	641112.ACOK01000071_gene2988	3.53e-196	566.0	COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia,3WG90@541000|Ruminococcaceae	186801|Clostridia	L	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4368,Recombinase,Resolvase,Zn_ribbon_recom
PKFBICOC_00849	1392491.JIAE01000001_gene2212	1.06e-95	302.0	COG3843@1|root,COG3843@2|Bacteria,1V2SB@1239|Firmicutes,24GQD@186801|Clostridia,3WGDT@541000|Ruminococcaceae	186801|Clostridia	U	Relaxase/Mobilisation nuclease domain	-	-	-	-	-	-	-	-	-	-	-	-	Relaxase
PKFBICOC_00850	1392491.JIAE01000001_gene260	9.3e-26	99.4	2DPJA@1|root,332BZ@2|Bacteria,1VFXE@1239|Firmicutes,25GFZ@186801|Clostridia,3WREI@541000|Ruminococcaceae	186801|Clostridia	S	Bacterial mobilisation protein (MobC)	-	-	-	-	-	-	-	-	-	-	-	-	MobC
PKFBICOC_00851	1121334.KB911069_gene1734	8.28e-77	247.0	COG1066@1|root,COG1066@2|Bacteria,1UHUE@1239|Firmicutes,25E2V@186801|Clostridia,3WGAV@541000|Ruminococcaceae	186801|Clostridia	O	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_25
PKFBICOC_00853	397287.C807_03076	5.18e-07	50.8	2DR02@1|root,339M9@2|Bacteria,1VKYZ@1239|Firmicutes,25IHK@186801|Clostridia,27S9U@186928|unclassified Lachnospiraceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00855	537013.CLOSTMETH_01821	0.0	989.0	COG4990@1|root,COG4990@2|Bacteria,1V6EZ@1239|Firmicutes,24IBA@186801|Clostridia,3WK2H@541000|Ruminococcaceae	186801|Clostridia	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2
PKFBICOC_00856	537013.CLOSTMETH_01821	3.05e-21	93.2	COG4990@1|root,COG4990@2|Bacteria,1V6EZ@1239|Firmicutes,24IBA@186801|Clostridia,3WK2H@541000|Ruminococcaceae	186801|Clostridia	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2
PKFBICOC_00859	180332.JTGN01000005_gene2811	4.28e-164	484.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	tRNA_U5-meth_tr
PKFBICOC_00860	1160721.RBI_II00514	2.84e-307	843.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,2490X@186801|Clostridia,3WGBX@541000|Ruminococcaceae	186801|Clostridia	C	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
PKFBICOC_00861	1160721.RBI_II00513	0.0	2651.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,3WHE2@541000|Ruminococcaceae	186801|Clostridia	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
PKFBICOC_00862	1120746.CCNL01000017_gene2937	0.0	948.0	COG3968@1|root,COG3968@2|Bacteria,2NP30@2323|unclassified Bacteria	2|Bacteria	S	Glutamine synthetase type III N terminal	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
PKFBICOC_00863	397287.C807_02916	9.43e-265	742.0	COG0004@1|root,COG0347@1|root,COG0004@2|Bacteria,COG0347@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,27ITM@186928|unclassified Lachnospiraceae	186801|Clostridia	EP	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
PKFBICOC_00864	515620.EUBELI_20604	1.25e-28	112.0	2C0W2@1|root,306ZY@2|Bacteria,1V5YY@1239|Firmicutes,24I0Q@186801|Clostridia,25YGF@186806|Eubacteriaceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,HTH_7,MqsA_antitoxin
PKFBICOC_00865	1121115.AXVN01000079_gene2738	6.61e-79	246.0	2BYUU@1|root,2Z7P3@2|Bacteria,1UYDK@1239|Firmicutes,249UN@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00866	246199.CUS_5563	2.92e-33	124.0	COG3707@1|root,COG3707@2|Bacteria,1V9FH@1239|Firmicutes,24JZU@186801|Clostridia,3WJ90@541000|Ruminococcaceae	186801|Clostridia	K	ANTAR domain protein	-	-	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
PKFBICOC_00867	1160721.RBI_II00014	9.3e-185	522.0	COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,247Q8@186801|Clostridia,3WH1G@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
PKFBICOC_00868	428125.CLOLEP_02638	0.0	2135.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,2498I@186801|Clostridia,3WG9X@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,DAP_epimerase,MGS
PKFBICOC_00869	500632.CLONEX_00534	8.2e-296	818.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
PKFBICOC_00870	1160721.RBI_II00016	1.5e-205	578.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,24969@186801|Clostridia,3WGFU@541000|Ruminococcaceae	186801|Clostridia	H	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
PKFBICOC_00871	1160721.RBI_I02050	2.38e-309	845.0	COG0423@1|root,COG0423@2|Bacteria,1TP94@1239|Firmicutes,248FB@186801|Clostridia,3WGTU@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
PKFBICOC_00873	406124.ACPC01000022_gene4114	8.76e-21	92.8	COG1878@1|root,COG1878@2|Bacteria,1UFUJ@1239|Firmicutes,4HD9U@91061|Bacilli,1ZQPZ@1386|Bacillus	91061|Bacilli	S	Putative cyclase	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
PKFBICOC_00874	1414720.CBYM010000030_gene1692	1.24e-59	193.0	COG0546@1|root,COG0546@2|Bacteria,1V3YI@1239|Firmicutes,24CRF@186801|Clostridia,36I2K@31979|Clostridiaceae	186801|Clostridia	C	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
PKFBICOC_00875	457412.RSAG_02996	2.21e-92	276.0	COG1636@1|root,COG1636@2|Bacteria,1TT7H@1239|Firmicutes,248EA@186801|Clostridia,3WGWP@541000|Ruminococcaceae	186801|Clostridia	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
PKFBICOC_00876	1280671.AUJH01000010_gene3518	2.03e-237	672.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,4BXQH@830|Butyrivibrio	186801|Clostridia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsP	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
PKFBICOC_00877	1042156.CXIVA_17750	5.87e-35	121.0	COG1925@1|root,COG1925@2|Bacteria,1VA0R@1239|Firmicutes,24QIP@186801|Clostridia,36KJQ@31979|Clostridiaceae	186801|Clostridia	G	HPr family	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
PKFBICOC_00878	471855.Shel_13280	9.68e-261	738.0	COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,2GJU4@201174|Actinobacteria,4CUBT@84998|Coriobacteriia	84998|Coriobacteriia	G	TIGRFAM PTS system, fructose subfamily, IIC	-	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
PKFBICOC_00879	1410661.JNKW01000008_gene2116	1.02e-118	350.0	COG1105@1|root,COG1105@2|Bacteria,1TQ36@1239|Firmicutes,249RK@186801|Clostridia	186801|Clostridia	H	Belongs to the carbohydrate kinase PfkB family. LacC subfamily	pfkB	-	2.7.1.56	ko:K00882	ko00051,map00051	-	R02071	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
PKFBICOC_00880	411467.BACCAP_02217	1.66e-88	270.0	COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,2498W@186801|Clostridia,269MK@186813|unclassified Clostridiales	186801|Clostridia	K	DeoR C terminal sensor domain	fruR	-	-	ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
PKFBICOC_00881	1410617.JHXH01000009_gene1645	9.28e-44	152.0	COG0664@1|root,COG0664@2|Bacteria,1V8K7@1239|Firmicutes,24JZ5@186801|Clostridia,3WPPC@541000|Ruminococcaceae	186801|Clostridia	K	COG COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
PKFBICOC_00882	246199.CUS_7762	0.0	1225.0	COG1327@1|root,COG1328@1|root,COG1327@2|Bacteria,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,3WHPK@541000|Ruminococcaceae	186801|Clostridia	F	Ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
PKFBICOC_00883	1504823.CCMM01000012_gene2171	5.16e-88	263.0	COG0602@1|root,COG0602@2|Bacteria	2|Bacteria	H	queuosine metabolic process	nrdG	-	1.97.1.4	ko:K04068	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
PKFBICOC_00884	1280682.AUKA01000010_gene106	2.09e-13	71.6	2EFW8@1|root,339NG@2|Bacteria,1VI6U@1239|Firmicutes,24UK7@186801|Clostridia,4C05M@830|Butyrivibrio	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00885	428125.CLOLEP_02735	3.84e-222	620.0	COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,3WHC9@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
PKFBICOC_00886	428125.CLOLEP_02733	5.5e-182	519.0	COG0460@1|root,COG0460@2|Bacteria,1TQ2H@1239|Firmicutes,248MU@186801|Clostridia,3WGG4@541000|Ruminococcaceae	186801|Clostridia	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
PKFBICOC_00887	536232.CLM_3488	1.18e-73	265.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,248A4@186801|Clostridia,36E3C@31979|Clostridiaceae	186801|Clostridia	M	penicillin-binding protein 1A	mrcB	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
PKFBICOC_00889	877420.ATVW01000013_gene1889	2.17e-138	401.0	COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,24831@186801|Clostridia,27IQ1@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Nitronate monooxygenase	fabK	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iHN637.CLJU_RS20775	NMO
PKFBICOC_00890	428125.CLOLEP_02717	3.08e-126	369.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,247UF@186801|Clostridia,3WGWD@541000|Ruminococcaceae	186801|Clostridia	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
PKFBICOC_00891	97139.C824_01712	5.43e-80	248.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,36EGR@31979|Clostridiaceae	186801|Clostridia	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
PKFBICOC_00892	1120746.CCNL01000006_gene340	2.2e-187	533.0	COG0304@1|root,COG0304@2|Bacteria,2NNSX@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179,2.3.1.41	ko:K00647,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
PKFBICOC_00893	35841.BT1A1_2172	1.12e-28	110.0	COG0511@1|root,COG0511@2|Bacteria,1VAB7@1239|Firmicutes,4HKCS@91061|Bacilli,1ZGFF@1386|Bacillus	91061|Bacilli	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
PKFBICOC_00894	877420.ATVW01000013_gene1893	8.1e-48	157.0	COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,24JAW@186801|Clostridia,27MSY@186928|unclassified Lachnospiraceae	186801|Clostridia	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
PKFBICOC_00895	394503.Ccel_0934	1.41e-215	608.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,25E48@186801|Clostridia,36DJ8@31979|Clostridiaceae	186801|Clostridia	I	acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
PKFBICOC_00896	428125.CLOLEP_02724	4.92e-125	367.0	COG0777@1|root,COG0777@2|Bacteria,1TP4U@1239|Firmicutes,248QK@186801|Clostridia,3WGZ8@541000|Ruminococcaceae	186801|Clostridia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
PKFBICOC_00897	428125.CLOLEP_02725	7.68e-130	375.0	COG0825@1|root,COG0825@2|Bacteria,1UHNS@1239|Firmicutes,25E47@186801|Clostridia,3WSKG@541000|Ruminococcaceae	186801|Clostridia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
PKFBICOC_00899	1121115.AXVN01000104_gene843	2.44e-239	673.0	COG0437@1|root,COG4624@1|root,COG0437@2|Bacteria,COG4624@2|Bacteria,1TQIR@1239|Firmicutes,248BS@186801|Clostridia,3XYSR@572511|Blautia	186801|Clostridia	C	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Fe_hyd_lg_C,Fer4,Fer4_6
PKFBICOC_00900	641112.ACOK01000055_gene3805	4.21e-43	154.0	COG1434@1|root,COG1434@2|Bacteria,1VA42@1239|Firmicutes,24HKK@186801|Clostridia,3WIGF@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
PKFBICOC_00903	718252.FP2_12630	6.75e-20	82.0	COG1396@1|root,COG1396@2|Bacteria,1UHV9@1239|Firmicutes,25E41@186801|Clostridia,3WRJQ@541000|Ruminococcaceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
PKFBICOC_00905	1120746.CCNL01000009_gene1026	1.03e-277	775.0	COG0018@1|root,COG0018@2|Bacteria,2NNSE@2323|unclassified Bacteria	2|Bacteria	J	Arginyl tRNA synthetase N terminal dom	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_1434	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
PKFBICOC_00906	1121335.Clst_2422	3.37e-12	67.4	COG4506@1|root,COG4506@2|Bacteria,1U49U@1239|Firmicutes,259FV@186801|Clostridia,3WKB8@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF1934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1934
PKFBICOC_00907	537013.CLOSTMETH_01149	2e-84	260.0	COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,3WGBW@541000|Ruminococcaceae	186801|Clostridia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
PKFBICOC_00908	428125.CLOLEP_02928	6.72e-55	185.0	2C2S8@1|root,33RGY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00909	428125.CLOLEP_02929	6.59e-26	97.1	COG0267@1|root,COG0267@2|Bacteria,1VEJ4@1239|Firmicutes,24QK0@186801|Clostridia,3WKQN@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
PKFBICOC_00911	428125.CLOLEP_02931	6.72e-84	251.0	COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,248XB@186801|Clostridia,3WJ0G@541000|Ruminococcaceae	186801|Clostridia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
PKFBICOC_00912	1121334.KB911074_gene2488	2.78e-83	247.0	COG0080@1|root,COG0080@2|Bacteria,1V1BS@1239|Firmicutes,24FSQ@186801|Clostridia,3WICR@541000|Ruminococcaceae	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
PKFBICOC_00913	1121334.KB911074_gene2487	3.35e-135	386.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,247JB@186801|Clostridia,3WH4A@541000|Ruminococcaceae	186801|Clostridia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
PKFBICOC_00914	1378168.N510_00681	6.26e-44	151.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes	1239|Firmicutes	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
PKFBICOC_00915	428125.CLOLEP_02936	4.41e-44	147.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia,3WJAG@541000|Ruminococcaceae	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
PKFBICOC_00916	1160721.RBI_II00479	0.0	989.0	COG1866@1|root,COG1866@2|Bacteria,1TPQV@1239|Firmicutes,248JE@186801|Clostridia,3WGXZ@541000|Ruminococcaceae	186801|Clostridia	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
PKFBICOC_00917	760011.Spico_0552	2.74e-122	363.0	COG0338@1|root,COG3177@1|root,COG0338@2|Bacteria,COG3177@2|Bacteria,2J6G2@203691|Spirochaetes	203691|Spirochaetes	H	Site-specific DNA-methyltransferase (Adenine-specific)	dam	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
PKFBICOC_00918	877411.JMMA01000002_gene197	9.47e-157	445.0	arCOG06575@1|root,2Z7V5@2|Bacteria,1UZHZ@1239|Firmicutes,247UQ@186801|Clostridia,3WJBC@541000|Ruminococcaceae	186801|Clostridia	L	Recognizes the double-stranded unmethylated sequence GATC and cleaves before G-1	dpnB	-	3.1.21.4	ko:K01155	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DpnII
PKFBICOC_00919	546271.Selsp_0628	2.87e-165	463.0	COG0863@1|root,COG0863@2|Bacteria,1TPR7@1239|Firmicutes,4H6UR@909932|Negativicutes	909932|Negativicutes	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
PKFBICOC_00920	553973.CLOHYLEM_06959	2.88e-11	65.1	2BVD7@1|root,32QT8@2|Bacteria,1V6S8@1239|Firmicutes,24JJP@186801|Clostridia,2215X@1506553|Lachnoclostridium	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00921	1034807.FBFL15_1362	2.26e-32	126.0	COG2819@1|root,COG2819@2|Bacteria,4NH6C@976|Bacteroidetes,1HY0J@117743|Flavobacteriia,2NUQN@237|Flavobacterium	976|Bacteroidetes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
PKFBICOC_00922	1140001.I571_00989	1.62e-42	147.0	COG0454@1|root,COG0456@2|Bacteria,1V1RG@1239|Firmicutes,4HFN7@91061|Bacilli,4B31W@81852|Enterococcaceae	91061|Bacilli	K	Protease synthase and sporulation negative regulatory protein pai 1	paiA	-	2.3.1.57	ko:K22441	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
PKFBICOC_00923	428125.CLOLEP_00762	4.62e-96	283.0	COG4869@1|root,COG4869@2|Bacteria,1V242@1239|Firmicutes,24EHP@186801|Clostridia,3WRUR@541000|Ruminococcaceae	186801|Clostridia	Q	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate	-	-	2.3.1.8	ko:K15024	ko00430,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00720,map01100,map01120,map01200	M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTAC
PKFBICOC_00924	428125.CLOLEP_00759	3.58e-106	309.0	COG1573@1|root,COG1573@2|Bacteria,1V267@1239|Firmicutes,24DFW@186801|Clostridia,3WIGX@541000|Ruminococcaceae	186801|Clostridia	L	Uracil-DNA glycosylase	udgA	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
PKFBICOC_00925	903814.ELI_1949	1.72e-115	336.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,25V4X@186806|Eubacteriaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PKFBICOC_00926	1280692.AUJL01000014_gene3250	1.87e-164	525.0	COG0577@1|root,COG1511@1|root,COG0577@2|Bacteria,COG1511@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia,36E94@31979|Clostridiaceae	186801|Clostridia	V	Permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
PKFBICOC_00927	1121334.KB911066_gene492	0.0	877.0	COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,247Z3@186801|Clostridia,3WHZH@541000|Ruminococcaceae	186801|Clostridia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
PKFBICOC_00928	1308866.J416_14497	4.68e-08	53.5	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli,470W4@74385|Gracilibacillus	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
PKFBICOC_00929	1120746.CCNL01000014_gene2197	2.17e-244	683.0	COG0154@1|root,COG0154@2|Bacteria,2NNSD@2323|unclassified Bacteria	2|Bacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
PKFBICOC_00930	1120746.CCNL01000014_gene2198	2.71e-222	626.0	COG0064@1|root,COG0064@2|Bacteria,2NNPK@2323|unclassified Bacteria	2|Bacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.12,6.3.5.6,6.3.5.7	ko:K01876,ko:K02434	ko00970,ko01100,map00970,map01100	M00359,M00360	R03905,R04212,R05577	RC00010,RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GatB_N,GatB_Yqey
PKFBICOC_00932	1280679.ATVX01000002_gene807	4.44e-295	809.0	COG1350@1|root,COG1350@2|Bacteria,1UI01@1239|Firmicutes,25E8Q@186801|Clostridia,4BWG1@830|Butyrivibrio	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PKFBICOC_00933	658088.HMPREF0987_00941	1.51e-94	289.0	COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia,27IMT@186928|unclassified Lachnospiraceae	186801|Clostridia	P	PBP superfamily domain	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
PKFBICOC_00934	1232443.BAIA02000126_gene1111	8e-134	387.0	COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia,267YJ@186813|unclassified Clostridiales	186801|Clostridia	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
PKFBICOC_00935	622312.ROSEINA2194_04398	1.34e-124	365.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia	186801|Clostridia	P	phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
PKFBICOC_00936	1121115.AXVN01000010_gene2779	3.71e-146	415.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,3XYGV@572511|Blautia	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
PKFBICOC_00937	877421.AUJT01000010_gene524	1.84e-54	181.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,27KAH@186928|unclassified Lachnospiraceae	186801|Clostridia	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
PKFBICOC_00938	476272.RUMHYD_02676	9.62e-87	263.0	COG0745@1|root,COG0745@2|Bacteria,1TQY9@1239|Firmicutes,24EFS@186801|Clostridia,3XYU2@572511|Blautia	186801|Clostridia	KT	Psort location Cytoplasmic, score 9.98	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
PKFBICOC_00939	1304880.JAGB01000002_gene1714	1.24e-119	370.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia	186801|Clostridia	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,sCache_like
PKFBICOC_00940	140626.JHWB01000009_gene1467	1.41e-220	634.0	COG1283@1|root,COG1283@2|Bacteria,1TP4K@1239|Firmicutes,247KT@186801|Clostridia	186801|Clostridia	P	Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
PKFBICOC_00941	1160721.RBI_I01635	3.88e-93	278.0	COG1272@1|root,COG1272@2|Bacteria,1TSFK@1239|Firmicutes,24CPT@186801|Clostridia,3WIMP@541000|Ruminococcaceae	186801|Clostridia	S	protein, hemolysin III	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
PKFBICOC_00942	633697.EubceDRAFT1_1554	2.16e-128	370.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia,25W6H@186806|Eubacteriaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PKFBICOC_00943	469596.HMPREF9488_00022	1.94e-60	215.0	COG2898@1|root,COG2898@2|Bacteria,1U5FR@1239|Firmicutes,3VQ4S@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00944	585394.RHOM_10215	0.0	946.0	COG0369@1|root,COG1151@2|Bacteria,1TP8X@1239|Firmicutes,247IN@186801|Clostridia	186801|Clostridia	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
PKFBICOC_00945	1232453.BAIF02000051_gene1068	3.43e-18	92.8	COG0392@1|root,COG0392@2|Bacteria,1TXG8@1239|Firmicutes,24A1A@186801|Clostridia,268DZ@186813|unclassified Clostridiales	186801|Clostridia	S	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
PKFBICOC_00946	1280663.ATVR01000034_gene1406	1.77e-84	253.0	2DBP0@1|root,2ZA6P@2|Bacteria,1V58E@1239|Firmicutes,24GG5@186801|Clostridia,4BZ73@830|Butyrivibrio	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00948	1226322.HMPREF1545_02484	4.03e-50	163.0	COG0517@1|root,COG0517@2|Bacteria,1V7XE@1239|Firmicutes,24HF5@186801|Clostridia,2N7DV@216572|Oscillospiraceae	186801|Clostridia	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
PKFBICOC_00949	1410638.JHXJ01000018_gene565	3.85e-59	192.0	COG0745@1|root,COG0745@2|Bacteria,1V5YC@1239|Firmicutes,25BJK@186801|Clostridia,3WSAK@541000|Ruminococcaceae	186801|Clostridia	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
PKFBICOC_00950	404380.Gbem_2153	5.33e-12	77.4	COG4251@1|root,COG4936@1|root,COG4251@2|Bacteria,COG4936@2|Bacteria	2|Bacteria	KT	Sensory domain found in PocR	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,GAF_2,GGDEF,HAMP,HATPase_c,HD,HD_5,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,PocR,Response_reg
PKFBICOC_00952	1282887.AUJG01000001_gene1541	1.72e-94	279.0	COG3760@1|root,COG3760@2|Bacteria,1V1JF@1239|Firmicutes,24FVD@186801|Clostridia	186801|Clostridia	J	YbaK proline--tRNA ligase associated domain protein	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
PKFBICOC_00953	1120746.CCNL01000017_gene2947	1.43e-22	111.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
PKFBICOC_00954	411463.EUBVEN_02376	4.24e-94	287.0	COG1131@1|root,COG1131@2|Bacteria,1TPQW@1239|Firmicutes,248F7@186801|Clostridia,25VUY@186806|Eubacteriaceae	186801|Clostridia	V	ABC-type multidrug transport system, ATPase component	ytrB	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PKFBICOC_00955	580331.Thit_0786	1.13e-13	73.9	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,42FJC@68295|Thermoanaerobacterales	186801|Clostridia	K	aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2,GntR
PKFBICOC_00956	1121334.KB911066_gene504	7.07e-141	403.0	COG1191@1|root,COG1191@2|Bacteria,1TPDD@1239|Firmicutes,24A1H@186801|Clostridia,3WGQ0@541000|Ruminococcaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigG	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
PKFBICOC_00957	428125.CLOLEP_02383	7.57e-30	109.0	COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,24MX9@186801|Clostridia,3WKB9@541000|Ruminococcaceae	186801|Clostridia	S	protein, YerC YecD	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
PKFBICOC_00958	1514668.JOOA01000002_gene3489	1.87e-72	229.0	COG2227@1|root,COG2227@2|Bacteria,1V218@1239|Firmicutes,25EUC@186801|Clostridia,3WSKE@541000|Ruminococcaceae	186801|Clostridia	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
PKFBICOC_00959	1120746.CCNL01000011_gene1736	2.38e-107	320.0	COG1281@1|root,COG1281@2|Bacteria,2NPFF@2323|unclassified Bacteria	2|Bacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0031647,GO:0036506,GO:0042026,GO:0042802,GO:0043167,GO:0043169,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0065007,GO:0065008	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
PKFBICOC_00960	1226325.HMPREF1548_01689	5.99e-239	662.0	COG1196@1|root,COG1196@2|Bacteria,1UQCD@1239|Firmicutes,24AY9@186801|Clostridia,36FC6@31979|Clostridiaceae	186801|Clostridia	D	Plasmid recombination enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Mob_Pre
PKFBICOC_00961	469596.HMPREF9488_02220	4.87e-120	383.0	COG0553@1|root,COG0827@1|root,COG4646@1|root,COG0553@2|Bacteria,COG0827@2|Bacteria,COG4646@2|Bacteria,1TPQA@1239|Firmicutes,3VNX4@526524|Erysipelotrichia	526524|Erysipelotrichia	L	Helicase C-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
PKFBICOC_00962	999413.HMPREF1094_00594	1.35e-91	303.0	COG0553@1|root,COG0827@1|root,COG4646@1|root,COG0553@2|Bacteria,COG0827@2|Bacteria,COG4646@2|Bacteria,1TPQA@1239|Firmicutes,3VNX4@526524|Erysipelotrichia	526524|Erysipelotrichia	L	Helicase C-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
PKFBICOC_00963	1226322.HMPREF1545_03225	4.39e-08	57.0	29Y2U@1|root,30JVS@2|Bacteria,1URRW@1239|Firmicutes,257ZI@186801|Clostridia,2N8M5@216572|Oscillospiraceae	186801|Clostridia	S	Protein of unknown function (DUF3848)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3848,DUF3849
PKFBICOC_00964	483218.BACPEC_01733	7.16e-134	390.0	COG0358@1|root,COG0358@2|Bacteria,1TSIU@1239|Firmicutes,2495Y@186801|Clostridia,26958@186813|unclassified Clostridiales	186801|Clostridia	L	Protein of unknown function (DUF3991)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3991,Toprim_2
PKFBICOC_00965	483218.BACPEC_01734	8.22e-47	159.0	COG4734@1|root,COG4734@2|Bacteria,1V4EF@1239|Firmicutes,2509P@186801|Clostridia,2690C@186813|unclassified Clostridiales	186801|Clostridia	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	DUF3846
PKFBICOC_00967	1321372.AQQB01000003_gene1497	1.69e-50	162.0	2CDK1@1|root,32G0D@2|Bacteria,1V6YH@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MobC
PKFBICOC_00968	742735.HMPREF9467_03136	3.24e-203	577.0	COG3843@1|root,COG3843@2|Bacteria,1TPRX@1239|Firmicutes,248VT@186801|Clostridia,222MK@1506553|Lachnoclostridium	186801|Clostridia	U	Relaxase/Mobilisation nuclease domain	-	-	-	-	-	-	-	-	-	-	-	-	Relaxase
PKFBICOC_00969	1504823.CCMM01000007_gene543	4.73e-26	109.0	295P2@1|root,2ZT0F@2|Bacteria	2|Bacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF3801
PKFBICOC_00970	469596.HMPREF9488_02227	1.64e-124	364.0	COG4227@1|root,COG4227@2|Bacteria,1V3C4@1239|Firmicutes,3VUM7@526524|Erysipelotrichia	526524|Erysipelotrichia	L	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00971	469596.HMPREF9488_02228	1.87e-17	75.5	2DIMJ@1|root,303N8@2|Bacteria,1TUWK@1239|Firmicutes,3VTZW@526524|Erysipelotrichia	526524|Erysipelotrichia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00972	1321372.AQQB01000003_gene1502	0.0	995.0	COG3505@1|root,COG3505@2|Bacteria,1TPCF@1239|Firmicutes,4H9ZN@91061|Bacilli,1WU5I@1307|Streptococcus suis	91061|Bacilli	U	Type IV secretory system Conjugative DNA transfer	traK	-	-	ko:K03205	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	T4SS-DNA_transf
PKFBICOC_00973	1321372.AQQB01000003_gene1503	6.31e-48	156.0	2DMPF@1|root,32SVU@2|Bacteria,1VA0M@1239|Firmicutes	1239|Firmicutes	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00974	999413.HMPREF1094_00583	1.53e-154	439.0	2DB6V@1|root,2Z7IJ@2|Bacteria,1TRNS@1239|Firmicutes,3VUMK@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00975	1321372.AQQB01000003_gene1505	1.26e-65	201.0	COG3451@1|root,COG3451@2|Bacteria,1V6F7@1239|Firmicutes	1239|Firmicutes	U	PrgI family protein	-	-	-	-	-	-	-	-	-	-	-	-	PrgI
PKFBICOC_00976	1321372.AQQB01000003_gene1506	0.0	1338.0	COG3451@1|root,COG3451@2|Bacteria,1TPDR@1239|Firmicutes,4HUB9@91061|Bacilli,1WSV1@1307|Streptococcus suis	91061|Bacilli	U	'COG3451 Type IV secretory pathway, VirB4 components'	XK27_00545	-	-	-	-	-	-	-	-	-	-	-	DUF87
PKFBICOC_00977	483218.BACPEC_01740	1.65e-79	247.0	COG4509@1|root,COG4509@2|Bacteria,1V7UG@1239|Firmicutes,24KBR@186801|Clostridia,2692U@186813|unclassified Clostridiales	186801|Clostridia	S	Sortase family	srtB	-	3.4.22.70	ko:K08600	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
PKFBICOC_00979	1203602.HMPREF1527_01443	6.81e-112	348.0	COG3593@1|root,COG3593@2|Bacteria	2|Bacteria	L	DNA synthesis involved in DNA repair	-	-	-	ko:K07459	-	-	-	-	ko00000	-	-	-	AAA_15,DUF2813
PKFBICOC_00980	742738.HMPREF9460_02040	3.5e-136	417.0	COG0741@1|root,COG0741@2|Bacteria,1V3F0@1239|Firmicutes,249C4@186801|Clostridia,26ADA@186813|unclassified Clostridiales	186801|Clostridia	M	CHAP domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,Lysozyme_like
PKFBICOC_00981	1280698.AUJS01000094_gene606	2e-50	162.0	COG1396@1|root,COG1396@2|Bacteria,1V7XY@1239|Firmicutes,24M2R@186801|Clostridia	186801|Clostridia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
PKFBICOC_00982	1408437.JNJN01000043_gene814	1.28e-38	134.0	2EJ5W@1|root,33CX3@2|Bacteria,1UPWT@1239|Firmicutes,25HQU@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_00983	397287.C807_01005	1.16e-15	77.0	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,24B23@186801|Clostridia,27M2S@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
PKFBICOC_00984	718252.FP2_31760	1.97e-24	105.0	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,24B23@186801|Clostridia,3WID1@541000|Ruminococcaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
PKFBICOC_00985	1050201.KB913034_gene800	1.35e-21	98.2	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,3VQ2Y@526524|Erysipelotrichia	526524|Erysipelotrichia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	-	-	-	-	-	-	-	-	-	LGT
PKFBICOC_00988	861454.HMPREF9099_02880	0.0	1361.0	COG1674@1|root,COG1674@2|Bacteria,1V7UZ@1239|Firmicutes,24PWS@186801|Clostridia	186801|Clostridia	D	FtsK SpoIIIE family protein	-	-	-	-	-	-	-	-	-	-	-	-	FtsK_SpoIIIE
PKFBICOC_00991	861454.HMPREF9099_02878	0.0	1790.0	COG0433@1|root,COG0433@2|Bacteria,1TQPR@1239|Firmicutes,249UU@186801|Clostridia,27J8W@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Domain of unknown function DUF87	-	-	-	-	-	-	-	-	-	-	-	-	DUF87
PKFBICOC_00992	861454.HMPREF9099_02877	4.81e-28	129.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CW_binding_1,VCBS
PKFBICOC_00997	1042163.BRLA_c018370	1.25e-28	113.0	COG0317@1|root,COG0317@2|Bacteria,1VC5K@1239|Firmicutes,4HKVH@91061|Bacilli,26YMH@186822|Paenibacillaceae	91061|Bacilli	KT	COG0317 Guanosine polyphosphate pyrophosphohydrolases synthetases	-	-	-	-	-	-	-	-	-	-	-	-	HD_4
PKFBICOC_00998	1122992.CBQQ010000029_gene1646	4.79e-294	817.0	COG2189@1|root,COG2189@2|Bacteria,4NFKE@976|Bacteroidetes,2FNVJ@200643|Bacteroidia	976|Bacteroidetes	L	COG2189 Adenine specific DNA methylase Mod	-	-	2.1.1.72	ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
PKFBICOC_00999	1235835.C814_01268	0.0	1048.0	COG1061@1|root,COG1061@2|Bacteria,1UQNX@1239|Firmicutes,249J9@186801|Clostridia,3WH11@541000|Ruminococcaceae	186801|Clostridia	KL	Type III restriction enzyme, res subunit	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
PKFBICOC_01001	742735.HMPREF9467_03112	2.77e-30	116.0	2DRUK@1|root,33D4I@2|Bacteria,1VMYD@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01003	1410633.JHWR01000011_gene153	3.53e-08	52.4	2BJF8@1|root,32DRV@2|Bacteria,1TUYI@1239|Firmicutes,25J06@186801|Clostridia,27T1B@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
PKFBICOC_01004	272563.CD630_20660	2.42e-36	143.0	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,247V6@186801|Clostridia,25QY8@186804|Peptostreptococcaceae	186801|Clostridia	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K14059	-	-	-	-	ko00000	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
PKFBICOC_01006	556261.HMPREF0240_03860	7.65e-10	60.5	COG1396@1|root,COG1397@1|root,COG1396@2|Bacteria,COG1397@2|Bacteria,1TSKF@1239|Firmicutes,25DA4@186801|Clostridia,36VE3@31979|Clostridiaceae	186801|Clostridia	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
PKFBICOC_01011	1122217.KB899613_gene1458	2.12e-273	756.0	COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,4H2WK@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
PKFBICOC_01012	883081.HMPREF9698_01490	8.19e-10	61.2	COG1396@1|root,COG2932@1|root,COG1396@2|Bacteria,COG2932@2|Bacteria,1VEVT@1239|Firmicutes,4HNRR@91061|Bacilli,27GX9@186828|Carnobacteriaceae	91061|Bacilli	K	Peptidase S24-like	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Peptidase_S24
PKFBICOC_01013	1121115.AXVN01000071_gene3936	6.69e-13	81.3	COG5492@1|root,COG5492@2|Bacteria,1VUQN@1239|Firmicutes,24CDA@186801|Clostridia,3Y0E9@572511|Blautia	186801|Clostridia	N	endoglucanase-related protein, glucosyl hydrolase family 9 protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,DUF11,DUF4430,Flg_new
PKFBICOC_01014	1160721.RBI_I01407	4.93e-94	284.0	COG1351@1|root,COG1351@2|Bacteria,1TRAA@1239|Firmicutes,249DJ@186801|Clostridia,3WGNR@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
PKFBICOC_01015	1120746.CCNL01000010_gene1423	3.34e-84	256.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.1.1.45,2.7.4.9,4.1.1.19	ko:K00560,ko:K00943,ko:K01585	ko00240,ko00330,ko00670,ko01100,ko01523,map00240,map00330,map00670,map01100,map01523	M00053,M00133	R00566,R02094,R02098,R02101	RC00002,RC00219,RC00299,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iNJ661.Rv3247c	Thymidylate_kin
PKFBICOC_01016	471870.BACINT_00694	1.36e-59	199.0	COG4866@1|root,COG4866@2|Bacteria,4NGJE@976|Bacteroidetes,2FNB2@200643|Bacteroidia,4AK9E@815|Bacteroidaceae	976|Bacteroidetes	S	Conserved protein	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	Acetyltransf_9,DUF2156
PKFBICOC_01017	762968.HMPREF9441_00004	1.54e-05	54.3	COG4552@1|root,COG4866@1|root,COG4552@2|Bacteria,COG4866@2|Bacteria,4NGJE@976|Bacteroidetes,2FNB2@200643|Bacteroidia	976|Bacteroidetes	S	Psort location Cytoplasmic, score 8.96	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	Acetyltransf_9,DUF2156
PKFBICOC_01018	1203550.HMPREF1475_01179	8.79e-51	168.0	COG0693@1|root,COG0693@2|Bacteria,4NPUE@976|Bacteroidetes,2FMXF@200643|Bacteroidia	976|Bacteroidetes	S	DJ-1 family	thiJ	-	3.5.1.124	ko:K03152	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
PKFBICOC_01019	945021.TEH_19900	1.33e-19	89.4	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,4HM35@91061|Bacilli,4B32U@81852|Enterococcaceae	91061|Bacilli	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0030272,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
PKFBICOC_01020	1120746.CCNL01000010_gene1427	2.92e-105	327.0	COG1559@1|root,COG1559@2|Bacteria,2NP75@2323|unclassified Bacteria	2|Bacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
PKFBICOC_01021	1235835.C814_00095	4.23e-154	448.0	COG0826@1|root,COG0826@2|Bacteria,1TPRE@1239|Firmicutes,248I3@186801|Clostridia,3WGFB@541000|Ruminococcaceae	186801|Clostridia	O	Peptidase U32	yhbU_1	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
PKFBICOC_01022	428125.CLOLEP_01892	0.0	1159.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,3WGEX@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
PKFBICOC_01025	457396.CSBG_00890	1.59e-137	395.0	COG0648@1|root,COG0648@2|Bacteria,1TP1D@1239|Firmicutes,2499E@186801|Clostridia,36F6F@31979|Clostridiaceae	186801|Clostridia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
PKFBICOC_01026	336407.RBE_0002	2.25e-25	99.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2UCCR@28211|Alphaproteobacteria,47FJQ@766|Rickettsiales	766|Rickettsiales	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
PKFBICOC_01027	479437.Elen_1892	3.94e-78	247.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4CVBT@84998|Coriobacteriia	84998|Coriobacteriia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
PKFBICOC_01028	445973.CLOBAR_02029	2.79e-74	238.0	COG0697@1|root,COG0697@2|Bacteria,1TRH8@1239|Firmicutes,24B85@186801|Clostridia	186801|Clostridia	EG	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	EamA
PKFBICOC_01029	500632.CLONEX_01450	1.05e-69	219.0	COG0637@1|root,COG0637@2|Bacteria,1VA5Z@1239|Firmicutes,24JNY@186801|Clostridia	186801|Clostridia	G	IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Mannitol_dh_C
PKFBICOC_01030	742733.HMPREF9469_03138	5.94e-206	585.0	COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,21YBJ@1506553|Lachnoclostridium	186801|Clostridia	E	amino acid carrier protein	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
PKFBICOC_01031	1235798.C817_01523	5.74e-98	289.0	COG1896@1|root,COG1896@2|Bacteria,1V3MK@1239|Firmicutes,24IBW@186801|Clostridia,27VN6@189330|Dorea	186801|Clostridia	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
PKFBICOC_01032	1336241.JAEB01000008_gene1087	0.0	896.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,25VFE@186806|Eubacteriaceae	186801|Clostridia	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
PKFBICOC_01033	428125.CLOLEP_01614	0.0	1046.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia,3WGA7@541000|Ruminococcaceae	186801|Clostridia	J	translation elongation	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
PKFBICOC_01034	411489.CLOL250_00996	2.91e-133	386.0	COG1284@1|root,COG1284@2|Bacteria,1TQTP@1239|Firmicutes,25CBN@186801|Clostridia,36WSY@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
PKFBICOC_01035	445972.ANACOL_01687	4.51e-145	424.0	COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia,3WGK3@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
PKFBICOC_01036	1507.HMPREF0262_02365	1.56e-234	666.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E4P@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
PKFBICOC_01037	428125.CLOLEP_00392	5.81e-244	690.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,3WGTD@541000|Ruminococcaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
PKFBICOC_01038	428125.CLOLEP_01129	2.33e-290	801.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,3WGBI@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
PKFBICOC_01039	697329.Rumal_0090	1.79e-133	384.0	COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,3WGWY@541000|Ruminococcaceae	186801|Clostridia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS19265	TIM
PKFBICOC_01040	1160721.RBI_II00637	4.38e-245	678.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,3WGM9@541000|Ruminococcaceae	186801|Clostridia	G	Phosphoglycerate kinase	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
PKFBICOC_01041	428125.CLOLEP_01125	2.57e-93	275.0	COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,24HVV@186801|Clostridia,3WIDH@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
PKFBICOC_01043	1410670.JHXF01000005_gene997	6.21e-36	147.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,3WGCB@541000|Ruminococcaceae	186801|Clostridia	D	Peptidase, M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
PKFBICOC_01044	523794.Lebu_1770	3.12e-37	132.0	COG1854@1|root,COG1854@2|Bacteria,379PQ@32066|Fusobacteria	32066|Fusobacteria	H	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)	luxS	-	4.4.1.21	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	M00609	R01291	RC00069,RC01929	ko00000,ko00001,ko00002,ko01000	-	-	-	LuxS
PKFBICOC_01045	1408322.JHYK01000022_gene1741	2.03e-56	193.0	COG3757@1|root,COG3757@2|Bacteria,1V5MP@1239|Firmicutes,24HFV@186801|Clostridia,27JZA@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Glycosyl hydrolases family 25	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_25
PKFBICOC_01047	573061.Clocel_1295	3.26e-34	141.0	COG1376@1|root,COG1376@2|Bacteria,1TQMA@1239|Firmicutes,248H0@186801|Clostridia,36DSK@31979|Clostridiaceae	186801|Clostridia	S	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,YkuD
PKFBICOC_01050	469596.HMPREF9488_02964	8.45e-17	81.6	COG4767@1|root,COG4767@2|Bacteria,1TU1G@1239|Firmicutes,3VRKC@526524|Erysipelotrichia	526524|Erysipelotrichia	V	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
PKFBICOC_01051	742738.HMPREF9460_03210	8.32e-82	253.0	COG0726@1|root,COG0726@2|Bacteria,1UZGG@1239|Firmicutes,249C9@186801|Clostridia,268VM@186813|unclassified Clostridiales	186801|Clostridia	G	Polysaccharide deacetylase	pdaB	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
PKFBICOC_01052	411467.BACCAP_02437	8.61e-252	701.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,2684B@186813|unclassified Clostridiales	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
PKFBICOC_01053	428125.CLOLEP_01986	1.59e-96	287.0	COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,249SF@186801|Clostridia,3WHD9@541000|Ruminococcaceae	186801|Clostridia	E	serine O-acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
PKFBICOC_01054	994573.T472_0203155	8.68e-41	144.0	COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,24J7Y@186801|Clostridia,36FYW@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
PKFBICOC_01055	1160721.RBI_II00118	2.13e-190	543.0	COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,3WH46@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
PKFBICOC_01056	428125.CLOLEP_01983	2.78e-68	214.0	COG2137@1|root,COG2137@2|Bacteria,1VAFI@1239|Firmicutes,25DPI@186801|Clostridia,3WSGY@541000|Ruminococcaceae	186801|Clostridia	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
PKFBICOC_01057	428125.CLOLEP_01982	1.15e-196	554.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,3WGST@541000|Ruminococcaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
PKFBICOC_01058	697329.Rumal_2214	1.96e-69	223.0	COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia,3WGK1@541000|Ruminococcaceae	186801|Clostridia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
PKFBICOC_01059	1120746.CCNL01000017_gene3067	4.08e-125	368.0	COG3872@1|root,COG3872@2|Bacteria,2NP59@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF1385)	prmC	-	-	-	-	-	-	-	-	-	-	-	DUF1385
PKFBICOC_01060	445972.ANACOL_01032	1.84e-123	375.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,3WGC1@541000|Ruminococcaceae	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
PKFBICOC_01061	428125.CLOLEP_01977	4.45e-139	396.0	COG0745@1|root,COG0745@2|Bacteria,1TPN8@1239|Firmicutes,248UA@186801|Clostridia,3WGQR@541000|Ruminococcaceae	186801|Clostridia	K	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
PKFBICOC_01062	428125.CLOLEP_01976	2.72e-37	149.0	COG0457@1|root,COG0457@2|Bacteria,1V0WM@1239|Firmicutes,24D57@186801|Clostridia,3WS6H@541000|Ruminococcaceae	186801|Clostridia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
PKFBICOC_01063	1514668.JOOA01000002_gene3410	3.43e-84	256.0	COG0220@1|root,COG0220@2|Bacteria,1TQCA@1239|Firmicutes,248YR@186801|Clostridia,3WIGB@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
PKFBICOC_01064	879212.DespoDRAFT_03262	3.72e-33	128.0	COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,42MHJ@68525|delta/epsilon subdivisions,2WM6S@28221|Deltaproteobacteria,2MJJ3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	NGG1p interacting factor 3	-	-	3.5.4.16	ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	NIF3
PKFBICOC_01065	1105031.HMPREF1141_2696	1.81e-41	147.0	COG2384@1|root,COG2384@2|Bacteria,1V3I4@1239|Firmicutes,24BJI@186801|Clostridia,36FNA@31979|Clostridiaceae	186801|Clostridia	S	SAM-dependent methyltransferase	trmK	-	2.1.1.217	ko:K06967	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_18,TrmK
PKFBICOC_01066	411473.RUMCAL_01098	2.27e-25	95.5	COG1251@1|root,COG1251@2|Bacteria,1W1DD@1239|Firmicutes,25EHF@186801|Clostridia,3WSM6@541000|Ruminococcaceae	186801|Clostridia	C	Hydrid cluster protein-associated redox disulfide domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
PKFBICOC_01067	428125.CLOLEP_02672	6.18e-212	603.0	COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia,3WH36@541000|Ruminococcaceae	186801|Clostridia	O	chelatase subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
PKFBICOC_01068	861450.HMPREF0080_01893	1.26e-24	103.0	COG1595@1|root,COG1595@2|Bacteria,1TP55@1239|Firmicutes,4H2TH@909932|Negativicutes	909932|Negativicutes	K	Belongs to the sigma-70 factor family	sigH	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	GerE,Sigma70_r2,Sigma70_r4_2
PKFBICOC_01069	1410617.JHXH01000018_gene1171	1.52e-46	150.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia,3WK5C@541000|Ruminococcaceae	186801|Clostridia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
PKFBICOC_01070	546271.Selsp_0701	3.84e-195	553.0	2DB9A@1|root,2Z7VI@2|Bacteria,1TT2W@1239|Firmicutes	1239|Firmicutes	S	Adenine-specific methyltransferase EcoRI	-	-	-	-	-	-	-	-	-	-	-	-	EcoRI_methylase
PKFBICOC_01071	457415.HMPREF1006_02508	1.97e-228	634.0	COG1403@1|root,COG1479@1|root,COG1403@2|Bacteria,COG1479@2|Bacteria,3TBZ6@508458|Synergistetes	508458|Synergistetes	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF262,HNH
PKFBICOC_01077	1507.HMPREF0262_00628	3.22e-51	167.0	COG4463@1|root,COG4463@2|Bacteria,1VAXT@1239|Firmicutes,24JH3@186801|Clostridia,36JKR@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the CtsR family	ctsR	-	-	ko:K03708	-	-	-	-	ko00000,ko03000	-	-	-	CtsR
PKFBICOC_01078	1382305.AZUC01000007_gene1475	3.06e-13	71.6	COG3880@1|root,COG3880@2|Bacteria,1V6YM@1239|Firmicutes,4HNM5@91061|Bacilli,26ICG@186818|Planococcaceae	91061|Bacilli	S	UvrB/uvrC motif	-	GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
PKFBICOC_01079	1449063.JMLS01000035_gene6327	4.16e-92	285.0	COG3869@1|root,COG3869@2|Bacteria,1TPBA@1239|Firmicutes,4HC6U@91061|Bacilli,26T89@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the specific phosphorylation of arginine residues in proteins	mcsB	GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
PKFBICOC_01080	1121334.KB911069_gene1714	0.0	1043.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,3WGYI@541000|Ruminococcaceae	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
PKFBICOC_01082	1121334.KB911069_gene1759	2.07e-28	103.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,3WKWP@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
PKFBICOC_01083	649747.HMPREF0083_02695	7.97e-32	113.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,4HKNN@91061|Bacilli,26Y76@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
PKFBICOC_01084	428125.CLOLEP_02173	3.97e-219	617.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,3WH5J@541000|Ruminococcaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
PKFBICOC_01085	1121334.KB911069_gene1756	6.65e-27	103.0	COG2739@1|root,COG2739@2|Bacteria,1VEGP@1239|Firmicutes,24QNM@186801|Clostridia,3WKPX@541000|Ruminococcaceae	186801|Clostridia	S	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein	-	-	-	ko:K09787	-	-	-	-	ko00000	-	-	-	UPF0122
PKFBICOC_01086	1105031.HMPREF1141_0230	2.23e-182	514.0	COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia,36UI2@31979|Clostridiaceae	186801|Clostridia	T	PhoH-like protein	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
PKFBICOC_01087	1121334.KB911069_gene1749	1.67e-82	248.0	COG0319@1|root,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,24MQZ@186801|Clostridia,3WIDY@541000|Ruminococcaceae	186801|Clostridia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	3.5.4.5	ko:K01489,ko:K07042	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000,ko03009	-	-	-	UPF0054
PKFBICOC_01088	1121423.JONT01000001_gene1980	2.08e-11	65.1	COG0818@1|root,COG0818@2|Bacteria,1VEGR@1239|Firmicutes,248FD@186801|Clostridia,262TJ@186807|Peptococcaceae	186801|Clostridia	M	Diacylglycerol kinase	dgkA	-	2.7.1.107,2.7.1.66	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240,R05626	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar,PAP2
PKFBICOC_01089	428125.CLOLEP_02165	9.94e-148	424.0	COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,24876@186801|Clostridia,3WGJ2@541000|Ruminococcaceae	186801|Clostridia	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
PKFBICOC_01091	1120746.CCNL01000010_gene1088	1.87e-80	249.0	COG1381@1|root,COG1381@2|Bacteria	2|Bacteria	L	Involved in DNA repair and RecF pathway recombination	recO	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
PKFBICOC_01092	1105031.HMPREF1141_0222	2.57e-298	845.0	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia,36EFY@31979|Clostridiaceae	186801|Clostridia	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
PKFBICOC_01093	411473.RUMCAL_01279	6.36e-59	188.0	COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia,3WIMH@541000|Ruminococcaceae	186801|Clostridia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
PKFBICOC_01094	428125.CLOLEP_02178	3.32e-124	358.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,247JF@186801|Clostridia,3WH8Z@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
PKFBICOC_01095	537013.CLOSTMETH_02429	8.8e-48	153.0	COG1925@1|root,COG1925@2|Bacteria,1VA0R@1239|Firmicutes,24QIP@186801|Clostridia,3WK5I@541000|Ruminococcaceae	186801|Clostridia	G	phosphocarrier, HPr family	ptsH	-	-	ko:K11184,ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
PKFBICOC_01096	1121334.KB911069_gene1763	4.05e-272	764.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,3WH2A@541000|Ruminococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
PKFBICOC_01097	1121334.KB911069_gene1764	3.39e-70	218.0	COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia,3WJC4@541000|Ruminococcaceae	186801|Clostridia	L	RNA methyltransferase, RsmD family	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
PKFBICOC_01098	445972.ANACOL_00440	1.83e-61	194.0	COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia,3WJBF@541000|Ruminococcaceae	186801|Clostridia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
PKFBICOC_01099	1120746.CCNL01000010_gene1105	3.1e-32	119.0	COG0711@1|root,COG0711@2|Bacteria	2|Bacteria	C	ATP synthesis coupled proton transport	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01100	1105031.HMPREF1141_1547	3.29e-28	109.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,36I1C@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
PKFBICOC_01101	1120746.CCNL01000010_gene1107	1.92e-132	385.0	COG0275@1|root,COG0275@2|Bacteria,2NP8Y@2323|unclassified Bacteria	2|Bacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
PKFBICOC_01103	1121334.KB911066_gene759	7.65e-228	662.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,3WGI4@541000|Ruminococcaceae	186801|Clostridia	M	Penicillin-binding Protein	spoVD	-	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
PKFBICOC_01104	428125.CLOLEP_02197	5.5e-124	366.0	COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,247S7@186801|Clostridia,3WHMP@541000|Ruminococcaceae	186801|Clostridia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
PKFBICOC_01105	1121334.KB911066_gene756	2.49e-124	373.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,3WHWW@541000|Ruminococcaceae	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
PKFBICOC_01106	428125.CLOLEP_02200	9.01e-176	500.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,3WGFH@541000|Ruminococcaceae	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
PKFBICOC_01107	428125.CLOLEP_02201	4.89e-183	523.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,3WG8Y@541000|Ruminococcaceae	186801|Clostridia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA2	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
PKFBICOC_01109	428125.CLOLEP_02204	3.23e-155	448.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,3WH3G@541000|Ruminococcaceae	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
PKFBICOC_01110	411469.EUBHAL_01060	1.46e-98	300.0	COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,2489U@186801|Clostridia,25VC0@186806|Eubacteriaceae	186801|Clostridia	S	TRAP transporter solute receptor, TAXI family	bcsP	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
PKFBICOC_01111	411469.EUBHAL_01061	2.33e-212	595.0	COG0786@1|root,COG0786@2|Bacteria,1TQA4@1239|Firmicutes,247WX@186801|Clostridia,25V8Y@186806|Eubacteriaceae	186801|Clostridia	P	Catalyzes the sodium-dependent transport of glutamate	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter,NMT1_3
PKFBICOC_01113	585394.RHOM_14915	6.86e-170	481.0	COG3049@1|root,COG3049@2|Bacteria,1TPZS@1239|Firmicutes,24B0E@186801|Clostridia	186801|Clostridia	M	Linear amide C-N hydrolase, choloylglycine hydrolase family protein	cbh	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CBAH
PKFBICOC_01114	457396.CSBG_03069	1.23e-115	350.0	COG0038@1|root,COG0038@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia,36FR4@31979|Clostridiaceae	186801|Clostridia	P	Chloride channel	eriC	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
PKFBICOC_01117	742738.HMPREF9460_03414	3.86e-19	79.3	2EG1V@1|root,339TV@2|Bacteria,1VKAZ@1239|Firmicutes,24UGV@186801|Clostridia,269V4@186813|unclassified Clostridiales	186801|Clostridia	S	Domain of unknown function (DUF4250)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4250
PKFBICOC_01118	1160721.RBI_I01220	2.8e-176	511.0	COG0029@1|root,COG0029@2|Bacteria,1UHSP@1239|Firmicutes,25E6F@186801|Clostridia,3WGEV@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
PKFBICOC_01119	428125.CLOLEP_03693	6.24e-134	387.0	COG0157@1|root,COG0157@2|Bacteria,1TPQC@1239|Firmicutes,248P2@186801|Clostridia,3WGJ1@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12010	QRPTase_C,QRPTase_N
PKFBICOC_01120	1321782.HMPREF1986_02722	4.51e-214	601.0	COG1373@1|root,COG1373@2|Bacteria,1TP7X@1239|Firmicutes,249UX@186801|Clostridia,2PR9I@265975|Oribacterium	186801|Clostridia	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
PKFBICOC_01121	398512.JQKC01000005_gene5374	2.24e-55	187.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,3WGKR@541000|Ruminococcaceae	186801|Clostridia	S	PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
PKFBICOC_01122	1235835.C814_01868	2.28e-85	268.0	COG2348@1|root,COG2348@2|Bacteria,1TRZU@1239|Firmicutes,24AU8@186801|Clostridia,3WI7M@541000|Ruminococcaceae	186801|Clostridia	V	Methicillin resistance	femX	-	2.3.2.10,2.3.2.16	ko:K05363,ko:K11693	ko00550,ko01100,map00550,map01100	-	R08776,R08779	RC00055,RC00096	ko00000,ko00001,ko01000,ko01011	-	-	-	FemAB
PKFBICOC_01124	537013.CLOSTMETH_01407	2.89e-77	256.0	COG0642@1|root,COG2205@2|Bacteria,1TRD2@1239|Firmicutes,247M3@186801|Clostridia,3WJ0M@541000|Ruminococcaceae	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
PKFBICOC_01125	1232446.BAIE02000018_gene1461	8.46e-87	263.0	COG0745@1|root,COG0745@2|Bacteria,1TT73@1239|Firmicutes,2487E@186801|Clostridia	186801|Clostridia	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
PKFBICOC_01127	1196322.A370_01710	2.03e-24	109.0	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,25E7B@186801|Clostridia,36GAX@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.113,2.6.1.55,2.6.1.62,2.6.1.77	ko:K00833,ko:K03851,ko:K12256,ko:K15372	ko00330,ko00410,ko00430,ko00780,ko01100,map00330,map00410,map00430,map00780,map01100	M00123,M00573,M00577	R00908,R01684,R03231,R05652,R08714	RC00006,RC00008,RC00062,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
PKFBICOC_01129	626939.HMPREF9443_00821	1.09e-69	217.0	COG0503@1|root,COG0503@2|Bacteria,1V1DU@1239|Firmicutes,4H42H@909932|Negativicutes	909932|Negativicutes	F	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis	xpt	-	2.4.2.22	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
PKFBICOC_01130	428125.CLOLEP_02052	1.21e-194	560.0	COG0591@1|root,COG0591@2|Bacteria,1TPVE@1239|Firmicutes,248NQ@186801|Clostridia,3WGAA@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	ko:K03307,ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21,2.A.21.2	-	-	SSF
PKFBICOC_01131	1105031.HMPREF1141_0022	8.67e-137	405.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,36ES8@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1,5.1.1.18	ko:K01775,ko:K18348	ko00473,ko01100,ko01502,ko02020,map00473,map01100,map01502,map02020	M00652	R00401	RC00285	ko00000,ko00001,ko00002,ko01000,ko01011,ko01504	-	-	-	Acyl_transf_3,Ala_racemase_C,Ala_racemase_N
PKFBICOC_01132	428125.CLOLEP_03726	0.0	987.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,3WGRT@541000|Ruminococcaceae	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
PKFBICOC_01133	663278.Ethha_2634	1.22e-26	104.0	COG0394@1|root,COG0394@2|Bacteria,1V6SG@1239|Firmicutes,24MMZ@186801|Clostridia,3WSE6@541000|Ruminococcaceae	186801|Clostridia	T	Low molecular weight phosphatase family	-	-	3.1.3.48,5.3.1.6	ko:K01104,ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LMWPc,LacAB_rpiB
PKFBICOC_01134	1235835.C814_00269	3.78e-40	139.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia,3WKHF@541000|Ruminococcaceae	186801|Clostridia	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
PKFBICOC_01135	1120746.CCNL01000004_gene59	7.88e-179	505.0	COG0533@1|root,COG0533@2|Bacteria,2NNXP@2323|unclassified Bacteria	2|Bacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	R10648	RC00070,RC00416	ko00000,ko00001,ko00002,ko01000,ko02044,ko03016	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Peptidase_M22
PKFBICOC_01136	1336241.JAEB01000005_gene1429	1.02e-101	296.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,247XN@186801|Clostridia,25W2U@186806|Eubacteriaceae	186801|Clostridia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
PKFBICOC_01137	1410670.JHXF01000020_gene2216	6.68e-172	488.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,3WGSG@541000|Ruminococcaceae	186801|Clostridia	M	UDP-glucose 4-epimerase	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
PKFBICOC_01142	428125.CLOLEP_00448	3.37e-34	117.0	COG0227@1|root,COG0227@2|Bacteria,1VEI2@1239|Firmicutes,24QNA@186801|Clostridia,3WKM9@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
PKFBICOC_01143	428125.CLOLEP_00447	2.31e-75	234.0	COG1994@1|root,COG1994@2|Bacteria,1V6D4@1239|Firmicutes,24K0D@186801|Clostridia,3WJN0@541000|Ruminococcaceae	186801|Clostridia	S	peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
PKFBICOC_01144	1120746.CCNL01000011_gene1688	2.44e-81	251.0	COG1354@1|root,COG1354@2|Bacteria,2NPM8@2323|unclassified Bacteria	2|Bacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
PKFBICOC_01145	1120746.CCNL01000011_gene1689	4.41e-69	216.0	COG1386@1|root,COG1386@2|Bacteria,2NPPM@2323|unclassified Bacteria	2|Bacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
PKFBICOC_01146	428125.CLOLEP_00444	1.47e-24	103.0	2EMWG@1|root,33FIR@2|Bacteria,1VN82@1239|Firmicutes,24UV8@186801|Clostridia,3WR68@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF2953)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2953
PKFBICOC_01147	428125.CLOLEP_00443	6.11e-47	156.0	COG3874@1|root,COG3874@2|Bacteria,1V6H7@1239|Firmicutes,24JJ5@186801|Clostridia,3WJU2@541000|Ruminococcaceae	186801|Clostridia	S	Sporulation protein YtfJ	ytfJ	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
PKFBICOC_01148	428125.CLOLEP_00442	3.1e-101	311.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,3WGET@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
PKFBICOC_01149	1514668.JOOA01000002_gene3224	1.07e-94	285.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,3WHAC@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
PKFBICOC_01150	1120746.CCNL01000011_gene1695	4.16e-117	357.0	COG4799@1|root,COG4799@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	mdcD	-	2.1.3.10,4.1.1.87	ko:K13932,ko:K13933,ko:K20510,ko:K20511	-	-	-	-	ko00000,ko01000,ko02000	3.B.1.1.4	-	-	Carboxyl_trans,MdcE
PKFBICOC_01151	237368.SCABRO_01762	0.000279	47.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2J0WT@203682|Planctomycetes	203682|Planctomycetes	C	Conserved carboxylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
PKFBICOC_01152	428125.CLOLEP_00436	9.36e-276	761.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,3WH2N@541000|Ruminococcaceae	186801|Clostridia	C	Pyruvate carboxylase, C-terminal domain subunit K01960	oadA	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
PKFBICOC_01155	877414.ATWA01000007_gene201	2.37e-32	142.0	COG4733@1|root,COG4733@2|Bacteria,1VU1V@1239|Firmicutes,24Y5S@186801|Clostridia,26CE8@186813|unclassified Clostridiales	2|Bacteria	G	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_48,Peptidase_M43,fn3
PKFBICOC_01156	877414.ATWA01000007_gene201	2.09e-36	154.0	COG4733@1|root,COG4733@2|Bacteria,1VU1V@1239|Firmicutes,24Y5S@186801|Clostridia,26CE8@186813|unclassified Clostridiales	2|Bacteria	G	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_48,Peptidase_M43,fn3
PKFBICOC_01157	411490.ANACAC_01419	4.9e-221	612.0	COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,247RH@186801|Clostridia	186801|Clostridia	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
PKFBICOC_01158	428125.CLOLEP_00059	1.43e-71	219.0	COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia,3WJ0F@541000|Ruminococcaceae	186801|Clostridia	E	Acetolactate synthase small	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
PKFBICOC_01159	428125.CLOLEP_00060	2.81e-279	776.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,3WHFZ@541000|Ruminococcaceae	186801|Clostridia	H	acetolactate synthase large subunit	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
PKFBICOC_01162	1120746.CCNL01000009_gene991	3.5e-187	550.0	COG2217@1|root,COG2217@2|Bacteria,2NNT4@2323|unclassified Bacteria	2|Bacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
PKFBICOC_01164	386415.NT01CX_2411	2.27e-215	613.0	COG3410@1|root,COG3410@2|Bacteria,1TT74@1239|Firmicutes,24CMS@186801|Clostridia,36HRC@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized conserved protein (DUF2075)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2075
PKFBICOC_01165	290402.Cbei_2021	9.96e-132	393.0	COG3410@1|root,COG3410@2|Bacteria,1TT74@1239|Firmicutes,24CMS@186801|Clostridia,36HRC@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized conserved protein (DUF2075)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2075
PKFBICOC_01166	1232449.BAHV02000008_gene631	8.78e-05	48.1	2DQ5Z@1|root,334WJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GP20
PKFBICOC_01167	1235799.C818_04221	1.88e-37	129.0	2E3WI@1|root,32YTQ@2|Bacteria,1VHE5@1239|Firmicutes,25IYB@186801|Clostridia,27SYM@186928|unclassified Lachnospiraceae	186801|Clostridia	S	YjcQ protein	-	-	-	-	-	-	-	-	-	-	-	-	YjcQ
PKFBICOC_01168	511680.BUTYVIB_00504	2.21e-54	200.0	2DBJI@1|root,2Z9M2@2|Bacteria,1V4CA@1239|Firmicutes,24IGG@186801|Clostridia,4BYMF@830|Butyrivibrio	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_7TM
PKFBICOC_01169	1280681.AUJZ01000003_gene1919	4.58e-47	174.0	COG4585@1|root,COG4585@2|Bacteria,1V4GJ@1239|Firmicutes,24M3N@186801|Clostridia,4BYYX@830|Butyrivibrio	186801|Clostridia	T	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01170	246199.CUS_7978	8.68e-74	229.0	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,24E7M@186801|Clostridia,3WJQ7@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K07694	ko02020,map02020	M00480	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
PKFBICOC_01173	592026.GCWU0000282_002052	3.51e-56	185.0	2A1UJ@1|root,30Q3Q@2|Bacteria,1V50E@1239|Firmicutes,24ITX@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01175	548479.HMPREF0573_10770	3.18e-34	137.0	2C1YG@1|root,2ZAA0@2|Bacteria,2GV42@201174|Actinobacteria,4D7DB@85005|Actinomycetales	201174|Actinobacteria	S	Domain of unknown function (DUF4428)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4428
PKFBICOC_01177	537011.PREVCOP_05487	6.68e-45	152.0	COG0071@1|root,COG0071@2|Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	hsp20	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
PKFBICOC_01178	1160721.RBI_I00834	1.33e-235	677.0	COG0514@1|root,COG0514@2|Bacteria,1TPN5@1239|Firmicutes,247ZA@186801|Clostridia,3WHAU@541000|Ruminococcaceae	186801|Clostridia	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
PKFBICOC_01179	545695.TREAZ_1436	9.23e-96	298.0	COG0400@1|root,COG0400@2|Bacteria,2J6EZ@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF2974)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2974
PKFBICOC_01180	411474.COPEUT_00176	1.41e-152	432.0	COG0708@1|root,COG0708@2|Bacteria,1TPFB@1239|Firmicutes,24849@186801|Clostridia	186801|Clostridia	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
PKFBICOC_01181	626939.HMPREF9443_01862	1.87e-29	104.0	COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes	1239|Firmicutes	C	rubredoxin	rubR2	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
PKFBICOC_01182	1410631.JHWZ01000003_gene1467	6.24e-94	277.0	COG1592@1|root,COG1592@2|Bacteria,1TSUY@1239|Firmicutes,248GY@186801|Clostridia,27IW7@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Rubrerythrin	rbr3A	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
PKFBICOC_01183	545695.TREAZ_0035	1.38e-40	139.0	COG0735@1|root,COG0735@2|Bacteria	2|Bacteria	P	belongs to the Fur family	fur	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
PKFBICOC_01184	1249480.B649_02635	8.93e-26	114.0	COG0726@1|root,COG1649@1|root,COG0726@2|Bacteria,COG1649@2|Bacteria,1MWR2@1224|Proteobacteria,43AG1@68525|delta/epsilon subdivisions,2YT1V@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	G	Hypothetical glycosyl hydrolase family 13	-	-	-	ko:K11931	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000	-	-	-	GHL13,Polysacc_deac_1
PKFBICOC_01185	411489.CLOL250_02176	5.02e-46	177.0	COG3307@1|root,COG3307@2|Bacteria,1UK9W@1239|Firmicutes,25FS0@186801|Clostridia,36KWE@31979|Clostridiaceae	186801|Clostridia	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
PKFBICOC_01186	713586.KB900536_gene296	6.51e-12	70.1	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,1WVZ9@135613|Chromatiales	135613|Chromatiales	S	subfamily IA, variant 1	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
PKFBICOC_01187	1443125.Z962_00255	1.85e-10	68.2	COG1595@1|root,COG1595@2|Bacteria,1VACS@1239|Firmicutes,24KS7@186801|Clostridia,36KH6@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
PKFBICOC_01188	428125.CLOLEP_03218	1.13e-63	196.0	2C5R4@1|root,31VPY@2|Bacteria,1V8EP@1239|Firmicutes,24JPJ@186801|Clostridia,3WJKA@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	TnpV
PKFBICOC_01189	1341157.RF007C_16260	0.0	1266.0	COG0507@1|root,COG0507@2|Bacteria,1TSBF@1239|Firmicutes,24D5A@186801|Clostridia	186801|Clostridia	L	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	AAA_30,UvrD_C_2,Viral_helicase1
PKFBICOC_01190	1235796.C815_01330	5.46e-166	471.0	COG0270@1|root,COG0270@2|Bacteria,1TS3G@1239|Firmicutes	1239|Firmicutes	H	Methyltransferase	dcm	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
PKFBICOC_01191	1175306.GWL_02420	6.59e-16	83.6	COG3440@1|root,COG3440@2|Bacteria,1N4JP@1224|Proteobacteria,2VVU0@28216|Betaproteobacteria,478C4@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	HNH endonuclease	-	-	-	ko:K07454	-	-	-	-	ko00000	-	-	-	HNH_2
PKFBICOC_01192	1401065.HMPREF2130_02765	4.18e-85	269.0	28HT5@1|root,2Z803@2|Bacteria,1PTN2@1224|Proteobacteria,2W23G@28216|Betaproteobacteria,3T5YM@506|Alcaligenaceae	28216|Betaproteobacteria	L	HpaII restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RE_HpaII
PKFBICOC_01193	445971.ANASTE_00885	8.44e-195	545.0	COG0270@1|root,COG0270@2|Bacteria,1TS3G@1239|Firmicutes,249Q9@186801|Clostridia,25VMQ@186806|Eubacteriaceae	186801|Clostridia	H	Psort location Cytoplasmic, score	dcm	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
PKFBICOC_01194	445971.ANASTE_00886	1.36e-68	210.0	COG3727@1|root,COG3727@2|Bacteria,1V3S8@1239|Firmicutes,24MYE@186801|Clostridia,25WIB@186806|Eubacteriaceae	186801|Clostridia	L	DNA mismatch endonuclease Vsr	vsr	-	-	ko:K07458	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF559,Vsr
PKFBICOC_01195	641112.ACOK01000108_gene1770	4.47e-16	72.8	COG3655@1|root,COG3655@2|Bacteria,1VEM0@1239|Firmicutes,24QPN@186801|Clostridia,3WKPK@541000|Ruminococcaceae	186801|Clostridia	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_26
PKFBICOC_01196	1203606.HMPREF1526_01052	1.6e-15	70.5	2CBNR@1|root,331FY@2|Bacteria,1VG69@1239|Firmicutes,24SAG@186801|Clostridia,36NT2@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01197	1507.HMPREF0262_00462	1.49e-50	162.0	2DBC6@1|root,2Z8BZ@2|Bacteria,1UHUS@1239|Firmicutes,25E39@186801|Clostridia	186801|Clostridia	S	Replication initiator protein A (RepA) N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	RepA_N
PKFBICOC_01198	1507.HMPREF0262_00461	1.85e-87	269.0	COG1475@1|root,COG1475@2|Bacteria,1TR7C@1239|Firmicutes,247TW@186801|Clostridia,36HAM@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the ParB family	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
PKFBICOC_01200	1507.HMPREF0262_01019	4.6e-177	516.0	COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia,36DU1@31979|Clostridiaceae	186801|Clostridia	L	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	DUF4368,Recombinase,Resolvase,Zn_ribbon_recom
PKFBICOC_01202	1161902.HMPREF0378_0144	8.21e-57	198.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase
PKFBICOC_01206	397290.C810_03845	1.27e-81	263.0	294J7@1|root,2ZRYS@2|Bacteria,1V478@1239|Firmicutes,24SKA@186801|Clostridia	186801|Clostridia	S	Replication initiation factor	-	-	-	-	-	-	-	-	-	-	-	-	Rep_trans
PKFBICOC_01212	1392491.JIAE01000001_gene123	8.56e-36	149.0	COG1595@1|root,COG1595@2|Bacteria,1V8Z0@1239|Firmicutes,24MIS@186801|Clostridia,3WM1J@541000|Ruminococcaceae	186801|Clostridia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
PKFBICOC_01216	97139.C824_05139	1.11e-30	129.0	COG3475@1|root,COG3475@2|Bacteria,1VBSV@1239|Firmicutes,24C5H@186801|Clostridia,36EWJ@31979|Clostridiaceae	186801|Clostridia	M	LICD family	-	-	-	ko:K07271	-	-	-	-	ko00000,ko01000	-	-	-	LicD
PKFBICOC_01217	877411.JMMA01000002_gene2599	2.32e-63	213.0	COG0451@1|root,COG0451@2|Bacteria,1TS59@1239|Firmicutes,247JP@186801|Clostridia,3WJ79@541000|Ruminococcaceae	186801|Clostridia	GM	epimerase dehydratase	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
PKFBICOC_01218	1160721.RBI_I00539	3.06e-108	319.0	COG1134@1|root,COG1134@2|Bacteria,1TQKK@1239|Firmicutes,24A5V@186801|Clostridia,3WHVP@541000|Ruminococcaceae	186801|Clostridia	GM	Psort location CytoplasmicMembrane, score	tagH	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
PKFBICOC_01219	1160721.RBI_I00538	8.07e-88	270.0	COG1682@1|root,COG1682@2|Bacteria,1TQZF@1239|Firmicutes,248R0@186801|Clostridia,3WKBW@541000|Ruminococcaceae	186801|Clostridia	GM	ABC-2 type transporter	tagG	-	-	ko:K09692	ko02010,map02010	M00251	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.104	-	-	ABC2_membrane
PKFBICOC_01220	1120746.CCNL01000011_gene1905	5.98e-100	308.0	COG0687@1|root,COG0687@2|Bacteria,2NPSD@2323|unclassified Bacteria	2|Bacteria	E	Bacterial extracellular solute-binding protein	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1,SBP_bac_6,SBP_bac_8
PKFBICOC_01221	411467.BACCAP_02123	1.34e-77	244.0	COG1177@1|root,COG1177@2|Bacteria,1V0VD@1239|Firmicutes,25E3C@186801|Clostridia,267MN@186813|unclassified Clostridiales	186801|Clostridia	E	Binding-protein-dependent transport system inner membrane component	potC	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
PKFBICOC_01222	1203606.HMPREF1526_02247	3.97e-75	237.0	COG1176@1|root,COG1176@2|Bacteria,1TQ7Z@1239|Firmicutes,247Y8@186801|Clostridia,36EF3@31979|Clostridiaceae	186801|Clostridia	P	ABC-type spermidine putrescine transport system, permease component I	potB	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
PKFBICOC_01223	1507.HMPREF0262_00678	7.87e-148	432.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,36EAA@31979|Clostridiaceae	186801|Clostridia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
PKFBICOC_01224	1216932.CM240_0788	4.92e-87	317.0	COG0366@1|root,COG0860@1|root,COG3664@1|root,COG0366@2|Bacteria,COG0860@2|Bacteria,COG3664@2|Bacteria,1TQSE@1239|Firmicutes,24C4V@186801|Clostridia,36GZS@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Big_2,CBM26,CBM53,CW_binding_1,Y_Y_Y
PKFBICOC_01226	1507.HMPREF0262_00544	1.4e-81	258.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,36DUP@31979|Clostridiaceae	186801|Clostridia	D	Cell shape determining protein, MreB Mrl family	mbl	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
PKFBICOC_01227	1121334.KB911070_gene1357	7.4e-43	151.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia	186801|Clostridia	S	ComF family	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
PKFBICOC_01228	428125.CLOLEP_01537	2.18e-285	808.0	COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,3WGP3@541000|Ruminococcaceae	186801|Clostridia	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
PKFBICOC_01229	428125.CLOLEP_00456	9.66e-68	216.0	COG3442@1|root,COG3442@2|Bacteria,1U7I9@1239|Firmicutes,24A80@186801|Clostridia,3WKVW@541000|Ruminococcaceae	186801|Clostridia	S	glutamine amidotransferase	-	-	-	ko:K07009	-	-	-	-	ko00000	-	-	-	GATase_3
PKFBICOC_01230	428125.CLOLEP_00455	3.8e-194	551.0	COG0769@1|root,COG0769@2|Bacteria,1UHY9@1239|Firmicutes,25E6X@186801|Clostridia,3WHF5@541000|Ruminococcaceae	186801|Clostridia	M	Domain of unknown function (DUF1727)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1727,Mur_ligase_M
PKFBICOC_01232	754027.HMPREF9554_03119	1.8e-77	237.0	COG0110@1|root,COG0110@2|Bacteria,2J8I3@203691|Spirochaetes	203691|Spirochaetes	S	Bacterial transferase hexapeptide (six repeats)	wbbJ	-	2.3.1.18,2.3.1.79	ko:K00633,ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2,Mac
PKFBICOC_01233	428125.CLOLEP_01459	1.34e-187	534.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,3WH00@541000|Ruminococcaceae	186801|Clostridia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
PKFBICOC_01234	588581.Cpap_2408	5.41e-36	131.0	COG0671@1|root,COG0671@2|Bacteria,1V7XD@1239|Firmicutes,25BF5@186801|Clostridia,3WS6D@541000|Ruminococcaceae	186801|Clostridia	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
PKFBICOC_01236	1410632.JHWW01000004_gene1539	8.65e-104	306.0	COG1207@1|root,COG1207@2|Bacteria,1UR9G@1239|Firmicutes,257VV@186801|Clostridia,27IDQ@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
PKFBICOC_01237	483218.BACPEC_01832	1.58e-289	795.0	COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,2688C@186813|unclassified Clostridiales	186801|Clostridia	S	'oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4
PKFBICOC_01238	1105031.HMPREF1141_1004	2.97e-177	521.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,36DBN@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
PKFBICOC_01239	1121334.KB911072_gene2672	2.27e-52	167.0	COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,3WJW1@541000|Ruminococcaceae	186801|Clostridia	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
PKFBICOC_01240	697329.Rumal_1263	1.34e-91	273.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,3WHNZ@541000|Ruminococcaceae	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
PKFBICOC_01241	1121334.KB911072_gene2674	5.4e-78	235.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,3WIZR@541000|Ruminococcaceae	186801|Clostridia	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
PKFBICOC_01244	1267005.KB911256_gene1623	2.94e-28	124.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,3N6J2@45401|Hyphomicrobiaceae	1224|Proteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
PKFBICOC_01245	33035.JPJF01000135_gene5078	1.36e-21	97.1	COG1802@1|root,COG3935@1|root,COG1802@2|Bacteria,COG3935@2|Bacteria,1VX1Z@1239|Firmicutes,25EAV@186801|Clostridia	186801|Clostridia	K	Conserved phage C-terminus (Phg_2220_C)	-	-	-	-	-	-	-	-	-	-	-	-	Phg_2220_C
PKFBICOC_01251	428125.CLOLEP_01534	1.28e-26	102.0	2CARW@1|root,33CNX@2|Bacteria,1W1RF@1239|Firmicutes,24X6E@186801|Clostridia,3WQR2@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01252	1120746.CCNL01000008_gene857	3.48e-17	74.3	2C3DI@1|root,33B22@2|Bacteria	2|Bacteria	S	Domain of Unknown Function (DUF1540)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1540
PKFBICOC_01253	1232446.BAIE02000072_gene3459	8.83e-16	84.0	COG0679@1|root,COG0679@2|Bacteria,1UY4N@1239|Firmicutes,24ACC@186801|Clostridia,26AFB@186813|unclassified Clostridiales	186801|Clostridia	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
PKFBICOC_01254	1211844.CBLM010000028_gene1902	4.03e-66	207.0	COG0778@1|root,COG0778@2|Bacteria,1V3ZT@1239|Firmicutes,3VQKT@526524|Erysipelotrichia	526524|Erysipelotrichia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PKFBICOC_01255	883156.HMPREF9282_01288	6.19e-87	259.0	COG0778@1|root,COG0778@2|Bacteria,1V4K6@1239|Firmicutes,4H4AS@909932|Negativicutes	909932|Negativicutes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
PKFBICOC_01256	742765.HMPREF9457_01906	1.39e-146	421.0	COG0583@1|root,COG0583@2|Bacteria,1TP3E@1239|Firmicutes,248HI@186801|Clostridia,27WHM@189330|Dorea	186801|Clostridia	K	Psort location Cytoplasmic, score 9.98	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
PKFBICOC_01257	1160721.RBI_I01026	5.97e-203	569.0	COG0620@1|root,COG0620@2|Bacteria,1TPDQ@1239|Firmicutes,248U0@186801|Clostridia,3WH02@541000|Ruminococcaceae	186801|Clostridia	E	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
PKFBICOC_01258	1408321.JNJD01000009_gene1864	1.74e-67	220.0	COG0842@1|root,COG0842@2|Bacteria,1TSH0@1239|Firmicutes,24BEN@186801|Clostridia,27MHV@186928|unclassified Lachnospiraceae	186801|Clostridia	V	ABC-2 type transporter	-	-	-	ko:K01992,ko:K11051	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC2_membrane,ABC2_membrane_3
PKFBICOC_01259	1410650.JHWL01000001_gene975	1.32e-104	314.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,4BY83@830|Butyrivibrio	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990,ko:K11050	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC_tran,DUF4162
PKFBICOC_01261	693746.OBV_28900	1.42e-39	137.0	COG3279@1|root,COG3279@2|Bacteria,1VA36@1239|Firmicutes,24NJ5@186801|Clostridia	186801|Clostridia	K	LytTr DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	LytTR
PKFBICOC_01264	1211844.CBLM010000103_gene2292	4.52e-26	122.0	COG1305@1|root,COG1305@2|Bacteria,1TP8K@1239|Firmicutes,3VRFE@526524|Erysipelotrichia	526524|Erysipelotrichia	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
PKFBICOC_01265	411474.COPEUT_00441	1.38e-08	63.9	COG1721@1|root,COG1721@2|Bacteria,1UZHY@1239|Firmicutes,24DE8@186801|Clostridia	186801|Clostridia	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
PKFBICOC_01266	1410638.JHXJ01000012_gene2628	1.02e-113	338.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia,3WGAD@541000|Ruminococcaceae	186801|Clostridia	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
PKFBICOC_01267	1519439.JPJG01000019_gene338	3.71e-122	357.0	COG0560@1|root,COG0560@2|Bacteria,1TRRS@1239|Firmicutes,249NX@186801|Clostridia,2N6BI@216572|Oscillospiraceae	186801|Clostridia	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
PKFBICOC_01268	1121334.KB911069_gene1717	1.83e-58	197.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,2504A@186801|Clostridia	186801|Clostridia	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
PKFBICOC_01269	428125.CLOLEP_02938	3.27e-125	367.0	COG0539@1|root,COG0539@2|Bacteria,1UV93@1239|Firmicutes,249P6@186801|Clostridia,3WH6M@541000|Ruminococcaceae	186801|Clostridia	J	S1 RNA binding domain protein	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
PKFBICOC_01270	545696.HOLDEFILI_01435	7.62e-131	391.0	COG1322@1|root,COG1322@2|Bacteria,1TPWI@1239|Firmicutes,3VQCE@526524|Erysipelotrichia	526524|Erysipelotrichia	S	RmuC domain protein	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
PKFBICOC_01272	397291.C804_05571	1.85e-15	85.9	COG4219@1|root,COG4219@2|Bacteria,1TQ0K@1239|Firmicutes,24AVI@186801|Clostridia,27JIN@186928|unclassified Lachnospiraceae	186801|Clostridia	KT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
PKFBICOC_01274	1203606.HMPREF1526_02400	2.29e-101	301.0	COG1738@1|root,COG1738@2|Bacteria,1TSAY@1239|Firmicutes,24EFG@186801|Clostridia,36Q0T@31979|Clostridiaceae	186801|Clostridia	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
PKFBICOC_01275	1029718.SFBM_1150	1.66e-114	333.0	COG1244@1|root,COG1244@2|Bacteria,1UZ5M@1239|Firmicutes,24AIM@186801|Clostridia,36G6G@31979|Clostridiaceae	186801|Clostridia	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01276	411470.RUMGNA_02867	3.29e-18	84.3	COG1399@1|root,COG1399@2|Bacteria,1VEXU@1239|Firmicutes,24RKT@186801|Clostridia,3Y029@572511|Blautia	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
PKFBICOC_01277	883081.HMPREF9698_00103	2.8e-12	62.0	COG0333@1|root,COG0333@2|Bacteria,1VEFI@1239|Firmicutes,4HNIZ@91061|Bacilli,27GR9@186828|Carnobacteriaceae	91061|Bacilli	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0003674,GO:0003735,GO:0005198	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
PKFBICOC_01278	428125.CLOLEP_00452	6.04e-169	488.0	COG1625@1|root,COG1625@2|Bacteria,1TSFU@1239|Firmicutes,247JK@186801|Clostridia,3WGI9@541000|Ruminococcaceae	186801|Clostridia	C	FeS-containing Cyanobacterial-specific oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
PKFBICOC_01279	428125.CLOLEP_00451	8.13e-231	645.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,3WGNU@541000|Ruminococcaceae	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
PKFBICOC_01280	428125.CLOLEP_00450	2.61e-62	202.0	COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,24JA2@186801|Clostridia,3WJFE@541000|Ruminococcaceae	186801|Clostridia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
PKFBICOC_01281	1196322.A370_05779	4.07e-47	154.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,36JIP@31979|Clostridiaceae	186801|Clostridia	FG	Hit family	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
PKFBICOC_01282	428125.CLOLEP_01895	1.05e-83	252.0	COG0503@1|root,COG0503@2|Bacteria,1V1XS@1239|Firmicutes,25QBJ@186801|Clostridia,3WIP6@541000|Ruminococcaceae	186801|Clostridia	F	Psort location Cytoplasmic, score	-	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
PKFBICOC_01284	428125.CLOLEP_01896	1.22e-53	206.0	COG0658@1|root,COG0658@2|Bacteria,1VGSX@1239|Firmicutes,249H4@186801|Clostridia,3WKE7@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence
PKFBICOC_01285	1262449.CP6013_2186	5.13e-28	119.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,24ASN@186801|Clostridia,36FMH@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
PKFBICOC_01286	1121334.KB911072_gene2649	3.2e-62	198.0	COG1658@1|root,COG1658@2|Bacteria,1V3K3@1239|Firmicutes,24I8W@186801|Clostridia,3WIWX@541000|Ruminococcaceae	186801|Clostridia	L	Ribonuclease M5	rnmV	-	3.1.26.8	ko:K05985	-	-	-	-	ko00000,ko01000	-	-	-	DUF4093,Toprim,Toprim_4
PKFBICOC_01287	357809.Cphy_3715	2.1e-21	90.5	COG4905@1|root,COG4905@2|Bacteria,1VA0H@1239|Firmicutes,24NAK@186801|Clostridia,2210T@1506553|Lachnoclostridium	186801|Clostridia	S	Psort location CytoplasmicMembrane, score 9.26	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_CmpB
PKFBICOC_01288	428125.CLOLEP_02644	1.45e-124	375.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3WGDS@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
PKFBICOC_01289	428125.CLOLEP_02951	4.81e-107	318.0	COG0740@1|root,COG0740@2|Bacteria,1TPX2@1239|Firmicutes,249QX@186801|Clostridia,3WGED@541000|Ruminococcaceae	186801|Clostridia	OU	Psort location Cytoplasmic, score	tepA	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
PKFBICOC_01290	1105031.HMPREF1141_2936	5.19e-93	285.0	COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,36EFN@31979|Clostridiaceae	186801|Clostridia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
PKFBICOC_01291	428125.CLOLEP_02952	2.21e-222	660.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia,3WGRB@541000|Ruminococcaceae	186801|Clostridia	D	Belongs to the FtsK SpoIIIE SftA family	spoIIIE	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
PKFBICOC_01292	428125.CLOLEP_02954	1.38e-310	863.0	COG1032@1|root,COG1032@2|Bacteria,1TQ8X@1239|Firmicutes,248IW@186801|Clostridia,3WGM7@541000|Ruminococcaceae	186801|Clostridia	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
PKFBICOC_01293	260799.BAS3966	2.04e-20	97.1	COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,4H9N3@91061|Bacilli,1ZGQD@1386|Bacillus	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,LTD,Lactamase_B
PKFBICOC_01294	1121115.AXVN01000001_gene1052	1.94e-227	634.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,3XYHR@572511|Blautia	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
PKFBICOC_01295	428125.CLOLEP_01583	9.37e-55	176.0	COG1970@1|root,COG1970@2|Bacteria,1VA14@1239|Firmicutes,24JAB@186801|Clostridia,3WISA@541000|Ruminococcaceae	186801|Clostridia	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
PKFBICOC_01296	515620.EUBELI_01018	1.79e-19	85.9	COG0671@1|root,COG0671@2|Bacteria,1VB2R@1239|Firmicutes,24MQ9@186801|Clostridia,25X1V@186806|Eubacteriaceae	186801|Clostridia	I	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
PKFBICOC_01297	1499683.CCFF01000017_gene1801	1.4e-265	747.0	COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia,36ERR@31979|Clostridiaceae	186801|Clostridia	E	asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
PKFBICOC_01298	693746.OBV_35770	5.34e-25	110.0	COG3314@1|root,COG3314@2|Bacteria,1TR0V@1239|Firmicutes,247XA@186801|Clostridia,2N6DP@216572|Oscillospiraceae	186801|Clostridia	S	Sporulation integral membrane protein YlbJ	ylbJ	-	-	-	-	-	-	-	-	-	-	-	Gate
PKFBICOC_01300	946235.CAER01000056_gene2928	5.33e-20	99.0	COG0561@1|root,COG0561@2|Bacteria,1TR3N@1239|Firmicutes,4HC8P@91061|Bacilli,23J2M@182709|Oceanobacillus	91061|Bacilli	S	Putative stage IV sporulation protein YqfD	yqfD	-	-	ko:K06438	-	-	-	-	ko00000	-	-	-	YqfD
PKFBICOC_01301	663278.Ethha_0207	7.38e-91	276.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,24967@186801|Clostridia,3WHB0@541000|Ruminococcaceae	186801|Clostridia	S	metallophosphoesterase	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
PKFBICOC_01302	428125.CLOLEP_03963	5.26e-231	655.0	COG1461@1|root,COG1461@2|Bacteria,1TQMX@1239|Firmicutes,247XI@186801|Clostridia,3WH9C@541000|Ruminococcaceae	186801|Clostridia	S	DAK2 domain fusion protein YloV	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
PKFBICOC_01303	411483.FAEPRAA2165_01818	3.53e-178	531.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,3WG7A@541000|Ruminococcaceae	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
PKFBICOC_01304	1120746.CCNL01000009_gene1037	1.34e-118	361.0	COG1686@1|root,COG1686@2|Bacteria,2NPJT@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
PKFBICOC_01305	665956.HMPREF1032_01357	2.01e-68	211.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,3WJ07@541000|Ruminococcaceae	186801|Clostridia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
PKFBICOC_01306	411469.EUBHAL_01639	1.54e-81	245.0	COG0716@1|root,COG0716@2|Bacteria,1V465@1239|Firmicutes,24DQZ@186801|Clostridia,25W9A@186806|Eubacteriaceae	186801|Clostridia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
PKFBICOC_01307	515620.EUBELI_00188	4.3e-89	264.0	COG1917@1|root,COG1917@2|Bacteria,1TRVH@1239|Firmicutes,249JY@186801|Clostridia,25VK4@186806|Eubacteriaceae	186801|Clostridia	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,CMD,Cupin_2
PKFBICOC_01308	411470.RUMGNA_00127	1.49e-47	158.0	COG0716@1|root,COG0716@2|Bacteria,1UUUV@1239|Firmicutes,25KCS@186801|Clostridia,3Y0VS@572511|Blautia	186801|Clostridia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
PKFBICOC_01309	1235799.C818_02530	2.97e-170	488.0	COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,27J6E@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Sodium:neurotransmitter symporter family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
PKFBICOC_01310	1410628.JNKS01000056_gene562	6.96e-49	157.0	COG2963@1|root,COG2963@2|Bacteria,1VHFV@1239|Firmicutes,25BV6@186801|Clostridia,27TEF@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
PKFBICOC_01311	1410626.JHXB01000038_gene80	4.66e-51	170.0	COG2801@1|root,COG2801@2|Bacteria,1TRUP@1239|Firmicutes,24AJD@186801|Clostridia,27KEC@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
PKFBICOC_01312	1410670.JHXF01000019_gene81	2.69e-61	197.0	COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,249HN@186801|Clostridia,3WJSC@541000|Ruminococcaceae	186801|Clostridia	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
PKFBICOC_01313	1410670.JHXF01000020_gene2215	1.77e-33	117.0	COG2963@1|root,COG2963@2|Bacteria,1VC5D@1239|Firmicutes,25AWW@186801|Clostridia,3WMPU@541000|Ruminococcaceae	1239|Firmicutes	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
PKFBICOC_01314	999413.HMPREF1094_00592	8.24e-38	136.0	COG0358@1|root,COG0358@2|Bacteria,1TSIU@1239|Firmicutes,3VQJE@526524|Erysipelotrichia	526524|Erysipelotrichia	L	Protein of unknown function (DUF3991)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3991,Toprim_2
PKFBICOC_01317	97139.C824_04415	4.24e-21	97.1	2AIFZ@1|root,32WHS@2|Bacteria,1VBMM@1239|Firmicutes,25HS6@186801|Clostridia,36UA2@31979|Clostridiaceae	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01320	318464.IO99_05385	7.27e-85	258.0	COG1131@1|root,COG1131@2|Bacteria,1V1P4@1239|Firmicutes,249VI@186801|Clostridia,36I6U@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter, ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
PKFBICOC_01322	97139.C824_04658	2.6e-18	84.0	COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia,36DU1@31979|Clostridiaceae	186801|Clostridia	L	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	DUF4368,Recombinase,Resolvase,Zn_ribbon_recom
PKFBICOC_01323	552396.HMPREF0863_00485	8.37e-30	117.0	COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,3VNR9@526524|Erysipelotrichia	526524|Erysipelotrichia	L	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	DUF4368,Recombinase,Resolvase,Zn_ribbon_recom
PKFBICOC_01324	1235799.C818_02530	1.59e-236	660.0	COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,27J6E@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Sodium:neurotransmitter symporter family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
PKFBICOC_01325	1120998.AUFC01000012_gene527	7.04e-101	298.0	COG0745@1|root,COG0745@2|Bacteria,1TPU2@1239|Firmicutes,24B71@186801|Clostridia,3WCI4@538999|Clostridiales incertae sedis	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	dltR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
PKFBICOC_01327	537013.CLOSTMETH_01392	1.4e-37	151.0	2CZ00@1|root,32T59@2|Bacteria,1VJ9C@1239|Firmicutes,24NTD@186801|Clostridia,3WPP0@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01328	1120998.AUFC01000012_gene527	7.04e-101	298.0	COG0745@1|root,COG0745@2|Bacteria,1TPU2@1239|Firmicutes,24B71@186801|Clostridia,3WCI4@538999|Clostridiales incertae sedis	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	dltR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
PKFBICOC_01329	1410625.JHWK01000004_gene666	7.35e-123	369.0	COG0642@1|root,COG2205@2|Bacteria,1UHUJ@1239|Firmicutes,25E2Z@186801|Clostridia,27KM4@186928|unclassified Lachnospiraceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	dltS	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
PKFBICOC_01331	78346.BRUM_0492	9.69e-55	183.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4CYTA@85004|Bifidobacteriales	201174|Actinobacteria	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PKFBICOC_01333	1235793.C809_00466	0.0	949.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia,27J01@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Alpha amylase, catalytic domain	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
PKFBICOC_01334	537013.CLOSTMETH_00841	3.6e-217	620.0	COG0366@1|root,COG4728@1|root,COG0366@2|Bacteria,COG4728@2|Bacteria,1TQFJ@1239|Firmicutes,249Y3@186801|Clostridia,3WGMX@541000|Ruminococcaceae	186801|Clostridia	G	Alpha amylase, catalytic domain protein	-	-	3.2.1.133,3.2.1.135,3.2.1.54,3.5.4.33	ko:K01208,ko:K11991	ko00500,ko01100,map00500,map01100	-	R02112,R03122,R10223,R11262	RC00477	ko00000,ko00001,ko01000,ko03016	-	GH13	-	Alpha-amylase,Alpha-amylase_C,DUF1653,Malt_amylase_C
PKFBICOC_01338	411473.RUMCAL_00965	1.05e-59	190.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,3WIS5@541000|Ruminococcaceae	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
PKFBICOC_01339	1203606.HMPREF1526_00607	5.32e-46	157.0	COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia,36IEQ@31979|Clostridiaceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
PKFBICOC_01340	428125.CLOLEP_02989	2.52e-199	558.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,3WGXE@541000|Ruminococcaceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
PKFBICOC_01341	428125.CLOLEP_02990	7.01e-213	600.0	COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,2499P@186801|Clostridia,3WGDW@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
PKFBICOC_01342	1120746.CCNL01000008_gene588	5.32e-171	481.0	COG1092@1|root,COG1092@2|Bacteria	2|Bacteria	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
PKFBICOC_01343	428125.CLOLEP_02992	1.33e-139	401.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,3WG9K@541000|Ruminococcaceae	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
PKFBICOC_01344	428125.CLOLEP_02993	1.89e-135	391.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,3WG8V@541000|Ruminococcaceae	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	cbiO	-	-	ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
PKFBICOC_01345	1120746.CCNL01000008_gene591	1.22e-100	301.0	COG0619@1|root,COG0619@2|Bacteria	2|Bacteria	P	transmembrane transporter activity	ecfT	-	-	ko:K16783,ko:K16785	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
PKFBICOC_01346	428125.CLOLEP_02995	1.1e-124	362.0	COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia,3WIKF@541000|Ruminococcaceae	186801|Clostridia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
PKFBICOC_01349	909943.HIMB100_00013920	0.000396	47.8	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2TUI7@28211|Alphaproteobacteria,4BQK8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	CDP-alcohol phosphatidyltransferase	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
PKFBICOC_01350	428125.CLOLEP_02998	0.0	956.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,2486F@186801|Clostridia,3WGI2@541000|Ruminococcaceae	186801|Clostridia	O	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03697	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small
PKFBICOC_01351	411463.EUBVEN_02432	3.11e-120	353.0	COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,24A48@186801|Clostridia,25UYF@186806|Eubacteriaceae	186801|Clostridia	P	sugar transport system permease	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
PKFBICOC_01352	1504822.CCNO01000011_gene91	5.23e-123	359.0	COG1175@1|root,COG1175@2|Bacteria,2NQWJ@2323|unclassified Bacteria	2|Bacteria	G	Binding-protein-dependent transport system inner membrane component	msmF	-	-	ko:K10118,ko:K15771	ko02010,map02010	M00196,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2,3.A.1.1.28	-	-	BPD_transp_1
PKFBICOC_01353	665956.HMPREF1032_01809	8.16e-202	572.0	COG1653@1|root,COG1653@2|Bacteria,1TQHT@1239|Firmicutes,249J6@186801|Clostridia,3WICE@541000|Ruminococcaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	amyE	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8,TAT_signal
PKFBICOC_01354	1105031.HMPREF1141_3054	6.09e-11	70.1	COG5578@1|root,COG5578@2|Bacteria,1V87X@1239|Firmicutes,24PJA@186801|Clostridia	186801|Clostridia	S	Protein of unknown function, DUF624	-	-	-	-	-	-	-	-	-	-	-	-	DUF624
PKFBICOC_01356	873448.STRPO_0013	0.00091	45.4	COG1396@1|root,COG2932@1|root,COG1396@2|Bacteria,COG2932@2|Bacteria,1V758@1239|Firmicutes,4HIKZ@91061|Bacilli	91061|Bacilli	K	DNA-binding helix-turn-helix protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,Peptidase_S24
PKFBICOC_01357	1120945.ATUW01000004_gene432	2.88e-38	130.0	COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4D5ZB@85005|Actinomycetales	201174|Actinobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
PKFBICOC_01358	1121334.KB911075_gene1802	0.0	1132.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,3WGQZ@541000|Ruminococcaceae	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
PKFBICOC_01359	411483.FAEPRAA2165_00683	2.1e-19	80.9	2CBNP@1|root,33J1I@2|Bacteria,1VP33@1239|Firmicutes,24WEX@186801|Clostridia,3WQQK@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01360	537013.CLOSTMETH_00282	5.45e-28	103.0	COG2026@1|root,COG2026@2|Bacteria,1UHB7@1239|Firmicutes,24T4T@186801|Clostridia,3WMC8@541000|Ruminococcaceae	186801|Clostridia	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
PKFBICOC_01361	397290.C810_02057	2.15e-195	551.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,27I60@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Flavodoxin_5,Lactamase_B
PKFBICOC_01362	1121344.JHZO01000001_gene443	1.02e-33	120.0	COG0640@1|root,COG0640@2|Bacteria,1VA6G@1239|Firmicutes,24JCN@186801|Clostridia,3WK18@541000|Ruminococcaceae	186801|Clostridia	K	regulatory protein, arsR	ziaR	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
PKFBICOC_01363	428125.CLOLEP_02666	4.3e-201	570.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,3WGXG@541000|Ruminococcaceae	186801|Clostridia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
PKFBICOC_01364	411473.RUMCAL_02677	3.87e-56	188.0	COG1235@1|root,COG1235@2|Bacteria,1TQ8E@1239|Firmicutes,249U2@186801|Clostridia,3WIBU@541000|Ruminococcaceae	186801|Clostridia	S	Metallo-beta-lactamase domain protein	yycJ	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
PKFBICOC_01365	537013.CLOSTMETH_01536	4.91e-56	180.0	COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia,3WIDB@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
PKFBICOC_01366	428125.CLOLEP_02682	3.83e-219	627.0	COG1293@1|root,COG1293@2|Bacteria,1TQ8A@1239|Firmicutes,248RK@186801|Clostridia,3WG7T@541000|Ruminococcaceae	186801|Clostridia	K	Fibronectin-binding protein	FbpA	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
PKFBICOC_01367	689781.AUJX01000010_gene419	1.27e-89	275.0	COG1313@1|root,COG1313@2|Bacteria,1TRUV@1239|Firmicutes,247VW@186801|Clostridia,2PRSD@265975|Oribacterium	186801|Clostridia	C	Radical SAM superfamily	PflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
PKFBICOC_01369	1499683.CCFF01000014_gene3594	5.44e-182	558.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia,36E5I@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	pulA	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
PKFBICOC_01370	888727.HMPREF9092_1451	6.79e-154	444.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,3WCEM@538999|Clostridiales incertae sedis	186801|Clostridia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
PKFBICOC_01371	1514668.JOOA01000002_gene968	7.68e-156	444.0	COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,247IJ@186801|Clostridia,3WGEP@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12020	NadA
PKFBICOC_01373	479437.Elen_1677	1.49e-58	194.0	COG4509@1|root,COG4509@2|Bacteria,2HVXP@201174|Actinobacteria,4CXPZ@84998|Coriobacteriia	84998|Coriobacteriia	S	Sortase family	-	-	3.4.22.70	ko:K08600	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
PKFBICOC_01374	180332.JTGN01000001_gene4588	1.5e-46	171.0	COG1316@1|root,COG1316@2|Bacteria,1UY3P@1239|Firmicutes,24H37@186801|Clostridia	186801|Clostridia	K	Cell envelope-like function transcriptional attenuator common domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
PKFBICOC_01375	1540257.JQMW01000011_gene1500	4.63e-37	144.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,248RH@186801|Clostridia,36EYW@31979|Clostridiaceae	186801|Clostridia	K	Cell envelope-related transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
PKFBICOC_01376	1105031.HMPREF1141_0987	6.8e-78	238.0	COG1896@1|root,COG1896@2|Bacteria,1TSDU@1239|Firmicutes,24FT8@186801|Clostridia,36IZU@31979|Clostridiaceae	186801|Clostridia	S	HD containing hydrolase-like enzyme	yfbR	-	3.1.3.89	ko:K07023,ko:K08722	ko00240,ko01100,map00240,map01100	-	R01569,R01664,R01968,R02088,R02102,R10776	RC00017	ko00000,ko00001,ko01000	-	-	-	HD_2,HD_3
PKFBICOC_01377	1105031.HMPREF1141_0986	1.5e-242	704.0	COG4485@1|root,COG4485@2|Bacteria,1TPVY@1239|Firmicutes,24C9R@186801|Clostridia,36VYV@31979|Clostridiaceae	186801|Clostridia	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
PKFBICOC_01378	796606.BMMGA3_13435	3.42e-72	242.0	COG0624@1|root,COG0624@2|Bacteria,1TPEG@1239|Firmicutes,4HC14@91061|Bacilli,1ZBI2@1386|Bacillus	91061|Bacilli	E	Dipeptidase	ytjP	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
PKFBICOC_01380	195103.CPF_0913	1.65e-100	307.0	COG1215@1|root,COG1215@2|Bacteria,1U4ZW@1239|Firmicutes,25P1E@186801|Clostridia,36EAF@31979|Clostridiaceae	186801|Clostridia	M	Succinoglycan biosynthesis protein exoa	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PKFBICOC_01381	997830.HMPREF1124_0933	2.58e-82	256.0	COG3475@1|root,COG3475@2|Bacteria,1TT6A@1239|Firmicutes,4HE2E@91061|Bacilli,43FUW@68892|Streptococcus infantis	91061|Bacilli	M	LicD family	licD3	-	-	ko:K07271	-	-	-	-	ko00000,ko01000	-	-	-	LicD
PKFBICOC_01382	272563.CD630_16850	3.63e-68	217.0	COG4912@1|root,COG4912@2|Bacteria,1TQII@1239|Firmicutes,248N8@186801|Clostridia,25RFD@186804|Peptostreptococcaceae	186801|Clostridia	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
PKFBICOC_01383	537007.BLAHAN_04528	1.29e-62	201.0	COG3601@1|root,COG3601@2|Bacteria,1V4BW@1239|Firmicutes,24E4V@186801|Clostridia,3XZK2@572511|Blautia	186801|Clostridia	S	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins	ribU	-	-	-	-	-	-	-	-	-	-	-	ECF_trnsprt
PKFBICOC_01384	1121335.Clst_2135	3.35e-23	98.2	COG3275@1|root,COG3275@2|Bacteria,1VB87@1239|Firmicutes,24UWN@186801|Clostridia,3WKXZ@541000|Ruminococcaceae	186801|Clostridia	T	Pfam:DUF3816	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS,ECF_trnsprt
PKFBICOC_01385	428125.CLOLEP_00515	1.63e-227	640.0	COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,248G1@186801|Clostridia,3WGRA@541000|Ruminococcaceae	186801|Clostridia	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
PKFBICOC_01386	1121334.KB911072_gene2599	2.9e-98	303.0	COG0448@1|root,COG0448@2|Bacteria,1TPZ3@1239|Firmicutes,2482Q@186801|Clostridia,3WGWM@541000|Ruminococcaceae	186801|Clostridia	G	Glucose-1-phosphate adenylyltransferase, GlgD subunit	glgD	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
PKFBICOC_01387	428125.CLOLEP_00513	7.13e-192	544.0	COG0448@1|root,COG0448@2|Bacteria,1TNZW@1239|Firmicutes,24943@186801|Clostridia,3WGWG@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
PKFBICOC_01388	428125.CLOLEP_00512	2.59e-282	793.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,3WGDM@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
PKFBICOC_01389	1160721.RBI_II00643	1.28e-218	606.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,3WGXW@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
PKFBICOC_01390	428125.CLOLEP_03967	1.15e-232	656.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,3WGE5@541000|Ruminococcaceae	186801|Clostridia	D	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
PKFBICOC_01391	411473.RUMCAL_00859	4.3e-218	611.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,3WGAK@541000|Ruminococcaceae	186801|Clostridia	U	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
PKFBICOC_01392	500632.CLONEX_00518	5.1e-50	162.0	COG0347@1|root,COG0347@2|Bacteria,1V9Z5@1239|Firmicutes,24MNA@186801|Clostridia	186801|Clostridia	K	Belongs to the P(II) protein family	glnB	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
PKFBICOC_01393	887929.HMP0721_0242	6.74e-33	127.0	2CWIF@1|root,32SZQ@2|Bacteria,1VBXK@1239|Firmicutes,24RR3@186801|Clostridia,25YTZ@186806|Eubacteriaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01394	994573.T472_0205785	9.25e-27	104.0	COG0824@1|root,COG0824@2|Bacteria,1VAGM@1239|Firmicutes,24NBX@186801|Clostridia,36JT8@31979|Clostridiaceae	186801|Clostridia	S	acyl-CoA thioester hydrolase, YbgC YbaW family	FcbC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
PKFBICOC_01395	1123405.AUMM01000016_gene2465	7.41e-258	723.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HE02@91061|Bacilli	91061|Bacilli	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
PKFBICOC_01396	1203606.HMPREF1526_03160	9.87e-170	488.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,36E5Q@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
PKFBICOC_01397	1002367.HMPREF0673_02461	1.17e-18	92.0	COG0583@1|root,COG0583@2|Bacteria,4NJY4@976|Bacteroidetes,2G2WS@200643|Bacteroidia	976|Bacteroidetes	K	LysR substrate binding domain	-	-	-	ko:K11921	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
PKFBICOC_01398	411473.RUMCAL_00791	2.06e-257	710.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,3WHK1@541000|Ruminococcaceae	186801|Clostridia	C	belongs to the iron- containing alcohol dehydrogenase family	adh	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
PKFBICOC_01399	596328.HMPREF0578_1303	2.38e-10	58.2	COG3077@1|root,COG3077@2|Bacteria,2GSWF@201174|Actinobacteria	201174|Actinobacteria	L	Addiction module antitoxin, RelB DinJ family	-	-	-	ko:K07473	-	-	-	-	ko00000,ko02048	-	-	-	RelB
PKFBICOC_01400	1504822.CCNO01000011_gene176	2.9e-198	562.0	COG0366@1|root,COG0366@2|Bacteria,2NPAG@2323|unclassified Bacteria	2|Bacteria	G	PFAM Alpha amylase, catalytic	malS	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
PKFBICOC_01401	1121115.AXVN01000001_gene1113	1.59e-95	300.0	COG0038@1|root,COG0038@2|Bacteria,1UZ4F@1239|Firmicutes,24921@186801|Clostridia	186801|Clostridia	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
PKFBICOC_01402	411463.EUBVEN_00894	7.82e-185	531.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,25VAA@186806|Eubacteriaceae	186801|Clostridia	V	CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	MatE
PKFBICOC_01404	500633.CLOHIR_01481	9.03e-186	521.0	COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,248MV@186801|Clostridia,25T34@186804|Peptostreptococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
PKFBICOC_01405	411470.RUMGNA_03389	3.35e-110	318.0	COG1592@1|root,COG1592@2|Bacteria,1V1FF@1239|Firmicutes,248V2@186801|Clostridia,3XZBD@572511|Blautia	186801|Clostridia	C	Psort location Cytoplasmic, score 8.87	rbr	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Rubrerythrin
PKFBICOC_01406	411473.RUMCAL_00439	1.23e-189	533.0	COG1613@1|root,COG1613@2|Bacteria,1TS25@1239|Firmicutes,24B9S@186801|Clostridia,3WGXR@541000|Ruminococcaceae	186801|Clostridia	P	Extracellular solute-binding protein	sbp	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
PKFBICOC_01407	411473.RUMCAL_00438	3.16e-150	428.0	COG0555@1|root,COG0555@2|Bacteria,1TQHR@1239|Firmicutes,24ACM@186801|Clostridia,3WIAX@541000|Ruminococcaceae	186801|Clostridia	P	Sulfate ABC transporter, permease protein CysT	cysT	-	-	ko:K02046,ko:K15496	ko00920,ko02010,map00920,map02010	M00185,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.6.5	-	-	BPD_transp_1
PKFBICOC_01408	59374.Fisuc_0151	4.3e-147	419.0	COG4208@1|root,COG4208@2|Bacteria	2|Bacteria	P	ATPase-coupled sulfate transmembrane transporter activity	cysW	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
PKFBICOC_01409	59374.Fisuc_0152	1.94e-180	510.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE_2,TOBE_3
PKFBICOC_01410	720554.Clocl_1557	2.14e-137	393.0	COG1179@1|root,COG1179@2|Bacteria,1TQ7A@1239|Firmicutes,248RA@186801|Clostridia,3WG8S@541000|Ruminococcaceae	186801|Clostridia	H	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1	thiF	-	-	ko:K22132	-	-	-	-	ko00000,ko03016	-	-	-	ThiF
PKFBICOC_01411	484770.UFO1_0016	9.74e-47	172.0	COG0373@1|root,COG0373@2|Bacteria,1TQN9@1239|Firmicutes,4H34I@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
PKFBICOC_01412	1160721.RBI_I00191	4.18e-43	150.0	COG1648@1|root,COG1648@2|Bacteria,1VA2E@1239|Firmicutes,24N6M@186801|Clostridia,3WKZJ@541000|Ruminococcaceae	186801|Clostridia	H	Putative NAD(P)-binding	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M
PKFBICOC_01413	1385515.N791_02050	4.51e-59	197.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1X4A7@135614|Xanthomonadales	135614|Xanthomonadales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
PKFBICOC_01414	1160721.RBI_I00189	2.09e-159	468.0	COG0007@1|root,COG0007@2|Bacteria,1TQNH@1239|Firmicutes,2487I@186801|Clostridia,3WHWX@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the precorrin methyltransferase family	cobA	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15755	HEM4,Porphobil_deam,Porphobil_deamC,TP_methylase
PKFBICOC_01415	1160721.RBI_I00188	1.19e-168	478.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,3WGUW@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS15750	ALAD
PKFBICOC_01416	1226325.HMPREF1548_06739	5.17e-197	558.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,36FBX@31979|Clostridiaceae	186801|Clostridia	H	Aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
PKFBICOC_01417	1384065.JAGS01000001_gene1529	1.58e-36	130.0	COG1959@1|root,COG1959@2|Bacteria,1V6RP@1239|Firmicutes,24KGB@186801|Clostridia,3WKDJ@541000|Ruminococcaceae	186801|Clostridia	K	transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
PKFBICOC_01418	1160721.RBI_I01810	8.17e-226	630.0	COG2873@1|root,COG2873@2|Bacteria,1TXZ1@1239|Firmicutes,248M7@186801|Clostridia,3WH3A@541000|Ruminococcaceae	186801|Clostridia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
PKFBICOC_01419	1160721.RBI_I01809	3.6e-171	481.0	COG2221@1|root,COG2221@2|Bacteria,1TR7P@1239|Firmicutes,2493K@186801|Clostridia,3WHZF@541000|Ruminococcaceae	186801|Clostridia	C	PFAM nitrite and sulphite reductase 4Fe-4S	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr
PKFBICOC_01420	1160721.RBI_I01808	4.73e-47	151.0	COG0425@1|root,COG0425@2|Bacteria,1VBET@1239|Firmicutes,24NV0@186801|Clostridia,3WJTK@541000|Ruminococcaceae	186801|Clostridia	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
PKFBICOC_01421	411473.RUMCAL_01835	2.12e-41	139.0	COG0526@1|root,COG0526@2|Bacteria,1UG1U@1239|Firmicutes,24SF7@186801|Clostridia,3WKHR@541000|Ruminococcaceae	186801|Clostridia	O	Thioredoxin-like domain	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
PKFBICOC_01422	1514668.JOOA01000002_gene1873	1.16e-30	108.0	COG2104@1|root,COG2104@2|Bacteria,1VFJR@1239|Firmicutes,24SEU@186801|Clostridia,3WKGM@541000|Ruminococcaceae	186801|Clostridia	H	TIGRFAM thiamine biosynthesis protein ThiS	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
PKFBICOC_01423	1160721.RBI_I01805	5.77e-178	497.0	COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,25CJC@186801|Clostridia,3WGRI@541000|Ruminococcaceae	186801|Clostridia	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
PKFBICOC_01424	411473.RUMCAL_01838	1.01e-76	230.0	COG1310@1|root,COG1310@2|Bacteria,1V6TY@1239|Firmicutes,24JI8@186801|Clostridia,3WJ1M@541000|Ruminococcaceae	186801|Clostridia	S	Mov34 MPN PAD-1 family	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
PKFBICOC_01425	1235802.C823_02218	2.15e-105	316.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,25VWS@186806|Eubacteriaceae	186801|Clostridia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
PKFBICOC_01426	411473.RUMCAL_01840	2.62e-313	864.0	COG1053@1|root,COG1053@2|Bacteria,1TRE8@1239|Firmicutes,247TH@186801|Clostridia,3WNS7@541000|Ruminococcaceae	186801|Clostridia	C	Fumarate reductase flavoprotein C-term	aprA	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
PKFBICOC_01427	411473.RUMCAL_01841	5.97e-47	152.0	COG1146@1|root,COG1146@2|Bacteria,1VADW@1239|Firmicutes,24MQA@186801|Clostridia,3WQFA@541000|Ruminococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_9
PKFBICOC_01428	59374.Fisuc_0146	1.5e-199	554.0	COG0175@1|root,COG0175@2|Bacteria	2|Bacteria	EH	sulfate reduction	cysD	-	1.8.4.10,1.8.4.8,2.7.7.4	ko:K00390,ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R02021,R04929	RC00007,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
PKFBICOC_01429	411473.RUMCAL_01843	1.82e-305	844.0	COG2895@1|root,COG2895@2|Bacteria,1UI8R@1239|Firmicutes,249BX@186801|Clostridia,3WSPE@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysN	-	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
PKFBICOC_01430	1298598.JCM21714_4747	5.1e-05	44.3	COG2314@1|root,COG2314@2|Bacteria,1VF2F@1239|Firmicutes,4HP9Y@91061|Bacilli,471ZJ@74385|Gracilibacillus	91061|Bacilli	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
PKFBICOC_01432	887929.HMP0721_0893	2.82e-80	243.0	COG0350@1|root,COG0350@2|Bacteria,1V2MB@1239|Firmicutes,24HJ0@186801|Clostridia,25W3N@186806|Eubacteriaceae	186801|Clostridia	H	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
PKFBICOC_01433	272563.CD630_05760	1.2e-09	68.6	COG0642@1|root,COG0642@2|Bacteria,1V7G1@1239|Firmicutes,25ER0@186801|Clostridia	186801|Clostridia	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_5
PKFBICOC_01434	1384057.CD33_13020	2.4e-07	58.9	COG3947@1|root,COG3947@2|Bacteria,1V85E@1239|Firmicutes,4HWPH@91061|Bacilli,3IW0K@400634|Lysinibacillus	91061|Bacilli	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Response_reg,Trans_reg_C
PKFBICOC_01436	1423816.BACQ01000037_gene1562	6.07e-06	53.5	COG4767@1|root,COG4767@2|Bacteria,1V04Y@1239|Firmicutes,4HDS5@91061|Bacilli,3F3SH@33958|Lactobacillaceae	91061|Bacilli	V	RDD family	ysaA	-	-	-	-	-	-	-	-	-	-	-	RDD,VanZ
PKFBICOC_01437	97139.C824_00379	0.0	2187.0	COG1020@1|root,COG3320@1|root,COG1020@2|Bacteria,COG3320@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae	186801|Clostridia	Q	TIGRFAM amino acid adenylation domain	-	-	6.1.1.13	ko:K03367	ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150	M00725	R02718	RC00037,RC00094	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding
PKFBICOC_01438	386456.JQKN01000009_gene1214	7.69e-101	324.0	COG0534@1|root,COG2172@1|root,arCOG01732@2157|Archaea,arCOG06892@2157|Archaea,2XVF5@28890|Euryarchaeota,23PHB@183925|Methanobacteria	183925|Methanobacteria	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
PKFBICOC_01439	1280664.AUIX01000037_gene2627	2.91e-22	90.1	COG1366@1|root,COG1366@2|Bacteria,1VB77@1239|Firmicutes,24NE7@186801|Clostridia,4BZWP@830|Butyrivibrio	186801|Clostridia	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
PKFBICOC_01440	410358.Mlab_1452	5.76e-23	100.0	COG2172@1|root,arCOG06892@2157|Archaea	2157|Archaea	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
PKFBICOC_01441	622312.ROSEINA2194_04008	2.87e-102	304.0	COG1296@1|root,COG1296@2|Bacteria,1TSXD@1239|Firmicutes,24CRN@186801|Clostridia	186801|Clostridia	E	branched-chain amino acid permease (azaleucine resistance)	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
PKFBICOC_01442	411483.FAEPRAA2165_02425	2.04e-37	128.0	2CCD5@1|root,32RVD@2|Bacteria,1UPQI@1239|Firmicutes,25HM0@186801|Clostridia,3WREV@541000|Ruminococcaceae	186801|Clostridia	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
PKFBICOC_01443	1408322.JHYK01000002_gene1254	3.88e-97	302.0	COG0420@1|root,COG0420@2|Bacteria,1TQY6@1239|Firmicutes,248VE@186801|Clostridia,27JDN@186928|unclassified Lachnospiraceae	186801|Clostridia	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
PKFBICOC_01444	1449335.JQLG01000004_gene618	1.75e-83	300.0	COG0419@1|root,COG0419@2|Bacteria,1TPCS@1239|Firmicutes,4H9Q3@91061|Bacilli,27FS7@186828|Carnobacteriaceae	91061|Bacilli	L	Putative exonuclease SbcCD, C subunit	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,AAA_29,SbcCD_C
PKFBICOC_01445	658655.HMPREF0988_00619	2.34e-119	348.0	COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,247Q2@186801|Clostridia,27IU0@186928|unclassified Lachnospiraceae	186801|Clostridia	P	ZIP Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
PKFBICOC_01446	411473.RUMCAL_02985	5.03e-33	116.0	2EGCF@1|root,33A48@2|Bacteria,1TV0R@1239|Firmicutes,2586M@186801|Clostridia,3WM1Y@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01447	1160721.RBI_I00794	0.0	886.0	COG2217@1|root,COG2217@2|Bacteria,1TPB8@1239|Firmicutes,247RZ@186801|Clostridia,3WHGR@541000|Ruminococcaceae	186801|Clostridia	P	Psort location CytoplasmicMembrane, score	copA_1	-	-	ko:K12950	-	-	-	-	ko00000,ko01000	3.A.3.32	-	-	E1-E2_ATPase,Hydrolase
PKFBICOC_01448	511680.BUTYVIB_01772	6.31e-30	118.0	COG5658@1|root,COG5658@2|Bacteria,1VBIT@1239|Firmicutes,24PFZ@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
PKFBICOC_01449	1499683.CCFF01000017_gene1562	2.31e-34	119.0	COG0640@1|root,COG0640@2|Bacteria,1VA3M@1239|Firmicutes,24NEC@186801|Clostridia,36KQM@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
PKFBICOC_01450	1211844.CBLM010000110_gene3478	1.06e-87	282.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,3VNYJ@526524|Erysipelotrichia	526524|Erysipelotrichia	V	Polysaccharide biosynthesis C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MatE
PKFBICOC_01451	1423724.BAMM01000002_gene415	4.25e-30	115.0	COG0454@1|root,COG0456@2|Bacteria,1VEW7@1239|Firmicutes,4HPE4@91061|Bacilli,3FBRU@33958|Lactobacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
PKFBICOC_01453	1392493.JIAB01000001_gene1584	3.15e-62	211.0	COG3274@1|root,COG3274@2|Bacteria,1V9EN@1239|Firmicutes,25CM5@186801|Clostridia,27U5U@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
PKFBICOC_01454	552396.HMPREF0863_00660	4.34e-283	815.0	COG1215@1|root,COG1887@1|root,COG1215@2|Bacteria,COG1887@2|Bacteria,1UYH3@1239|Firmicutes	1239|Firmicutes	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Glyphos_transf
PKFBICOC_01455	411463.EUBVEN_01214	9.54e-94	277.0	COG4475@1|root,COG4475@2|Bacteria,1V3H0@1239|Firmicutes,24HEU@186801|Clostridia,25WKB@186806|Eubacteriaceae	186801|Clostridia	S	Protein of unknown function (DUF436)	-	-	-	-	-	-	-	-	-	-	-	-	DUF436
PKFBICOC_01456	1235793.C809_01817	8.22e-68	209.0	COG0454@1|root,COG0456@2|Bacteria,1V77V@1239|Firmicutes,24MDJ@186801|Clostridia,27MDF@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
PKFBICOC_01457	1121115.AXVN01000092_gene77	0.0	997.0	COG0480@1|root,COG0480@2|Bacteria,1TPQH@1239|Firmicutes,247X4@186801|Clostridia,3XYMW@572511|Blautia	186801|Clostridia	J	Psort location Cytoplasmic, score 9.98	tetP	-	-	-	-	-	-	-	-	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,NYN_YacP
PKFBICOC_01458	460265.Mnod_0129	4e-64	216.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3
PKFBICOC_01459	509191.AEDB02000096_gene3503	2.57e-179	512.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,2491B@186801|Clostridia,3WGIG@541000|Ruminococcaceae	186801|Clostridia	E	Aminotransferase class I and II	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
PKFBICOC_01463	1235797.C816_02616	1.47e-49	162.0	COG0242@1|root,COG0242@2|Bacteria,1V73T@1239|Firmicutes,24FT0@186801|Clostridia,2N7D7@216572|Oscillospiraceae	186801|Clostridia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins	def2	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
PKFBICOC_01464	938293.CAJU020000020_gene285	6.96e-06	54.3	COG5660@1|root,COG5660@2|Bacteria,1VKXY@1239|Firmicutes,24UK9@186801|Clostridia,22I02@1570339|Peptoniphilaceae	186801|Clostridia	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
PKFBICOC_01465	1519439.JPJG01000058_gene2043	4.91e-42	144.0	COG1595@1|root,COG1595@2|Bacteria,1V8GV@1239|Firmicutes,24JEH@186801|Clostridia,2N7FS@216572|Oscillospiraceae	186801|Clostridia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
PKFBICOC_01467	97139.C824_05395	3.34e-69	212.0	COG0789@1|root,COG0789@2|Bacteria,1V3QI@1239|Firmicutes,25B3D@186801|Clostridia	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
PKFBICOC_01469	515620.EUBELI_20326	4.22e-70	225.0	COG4667@1|root,COG4667@2|Bacteria,1TQ9W@1239|Firmicutes,2485C@186801|Clostridia,25VW9@186806|Eubacteriaceae	186801|Clostridia	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
PKFBICOC_01470	189426.PODO_29870	8.15e-09	60.8	COG1309@1|root,COG1309@2|Bacteria,1V45P@1239|Firmicutes,4HHJU@91061|Bacilli,26VXN@186822|Paenibacillaceae	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_8,TetR_N
PKFBICOC_01471	1410638.JHXJ01000001_gene1913	1.28e-84	258.0	COG0655@1|root,COG0655@2|Bacteria,1TRKM@1239|Firmicutes,24AD6@186801|Clostridia,3WJYP@541000|Ruminococcaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_2,SCP2
PKFBICOC_01472	515620.EUBELI_20279	2.97e-60	190.0	COG0764@1|root,COG0764@2|Bacteria,1VWSM@1239|Firmicutes,252FM@186801|Clostridia	186801|Clostridia	I	K02372 3R-hydroxymyristoyl ACP dehydrase	-	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
PKFBICOC_01473	1410638.JHXJ01000001_gene1912	1.75e-106	314.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,3WGIW@541000|Ruminococcaceae	186801|Clostridia	IQ	reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
PKFBICOC_01474	1410638.JHXJ01000001_gene1911	1.19e-262	750.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,3WGGB@541000|Ruminococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
PKFBICOC_01475	1410638.JHXJ01000001_gene1910	3.98e-26	98.6	COG0236@1|root,COG0236@2|Bacteria,1W4GV@1239|Firmicutes,255Z4@186801|Clostridia	186801|Clostridia	IQ	Phosphopantetheine attachment site	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
PKFBICOC_01476	1313421.JHBV01000138_gene1215	7.66e-10	66.6	COG0204@1|root,COG2227@1|root,COG4258@1|root,COG0204@2|Bacteria,COG2227@2|Bacteria,COG4258@2|Bacteria,4PKBM@976|Bacteroidetes,1IQPB@117747|Sphingobacteriia	976|Bacteroidetes	I	Phosphate acyltransferases	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	Acyltransferase,MMPL,Methyltransf_25,Methyltransf_31
PKFBICOC_01477	411473.RUMCAL_00834	5.37e-232	641.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia,3WGS4@541000|Ruminococcaceae	186801|Clostridia	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
PKFBICOC_01478	903814.ELI_0510	3.58e-147	426.0	COG3049@1|root,COG3049@2|Bacteria,1TRTI@1239|Firmicutes,24AFG@186801|Clostridia,25X6F@186806|Eubacteriaceae	186801|Clostridia	M	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT,CBAH
PKFBICOC_01479	478749.BRYFOR_09130	2.7e-139	413.0	COG3290@1|root,COG3290@2|Bacteria,1UY02@1239|Firmicutes,24BV9@186801|Clostridia	186801|Clostridia	T	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_5
PKFBICOC_01480	478749.BRYFOR_09129	4.09e-77	240.0	COG3279@1|root,COG3279@2|Bacteria,1VA5A@1239|Firmicutes,24DB9@186801|Clostridia	186801|Clostridia	T	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
PKFBICOC_01481	97139.C824_00384	0.0	949.0	COG2015@1|root,COG2015@2|Bacteria,1TR7Q@1239|Firmicutes,248SN@186801|Clostridia,36K01@31979|Clostridiaceae	186801|Clostridia	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
PKFBICOC_01486	457421.CBFG_04902	3.79e-93	279.0	COG1394@1|root,COG1394@2|Bacteria,1TQ1Y@1239|Firmicutes,247TC@186801|Clostridia,268C8@186813|unclassified Clostridiales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
PKFBICOC_01487	1232443.BAIA02000097_gene3413	1.07e-288	793.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,267RU@186813|unclassified Clostridiales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
PKFBICOC_01488	641112.ACOK01000082_gene3311	2.12e-316	874.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,3WGBK@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	ntpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
PKFBICOC_01489	1232443.BAIA02000097_gene3411	1.72e-31	114.0	COG1436@1|root,COG1436@2|Bacteria,1VAX7@1239|Firmicutes,24MXC@186801|Clostridia	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
PKFBICOC_01492	1151292.QEW_3577	5.39e-38	134.0	COG0636@1|root,COG0636@2|Bacteria,1V786@1239|Firmicutes,24HBF@186801|Clostridia,25TT6@186804|Peptostreptococcaceae	186801|Clostridia	C	ATP synthase subunit C	ntpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
PKFBICOC_01493	1235835.C814_00054	3.93e-145	444.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,3WHFQ@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the V-ATPase 116 kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
PKFBICOC_01495	887929.HMP0721_0588	1.71e-21	98.6	COG2932@1|root,COG2932@2|Bacteria,1TQWX@1239|Firmicutes,24CWA@186801|Clostridia,25VQA@186806|Eubacteriaceae	186801|Clostridia	K	Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,Peptidase_S24
PKFBICOC_01496	1216932.CM240_2575	4.64e-05	47.0	COG1813@1|root,COG1813@2|Bacteria,1V7HU@1239|Firmicutes,24BDX@186801|Clostridia,36EZN@31979|Clostridiaceae	186801|Clostridia	K	Helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31
PKFBICOC_01499	445972.ANACOL_00518	4.73e-247	704.0	COG2801@1|root,COG2801@2|Bacteria,1UPNA@1239|Firmicutes,25DR7@186801|Clostridia,3WSH1@541000|Ruminococcaceae	186801|Clostridia	L	Mu transposase, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	DDE_2,HTH_Tnp_Mu_2,Mu-transpos_C,rve
PKFBICOC_01500	1160721.RBI_II00554	1.29e-66	218.0	COG2842@1|root,COG2842@2|Bacteria,1UZ2M@1239|Firmicutes,24DN9@186801|Clostridia,3WH73@541000|Ruminococcaceae	186801|Clostridia	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
PKFBICOC_01502	445972.ANACOL_00522	8.77e-30	111.0	2DP5S@1|root,330N4@2|Bacteria,1VH2J@1239|Firmicutes,24RDY@186801|Clostridia,3WM4I@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01506	552398.HMPREF0866_03127	6.7e-36	129.0	2CKR3@1|root,32SCV@2|Bacteria,1VBB0@1239|Firmicutes,24QB4@186801|Clostridia,3WJYD@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1018)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1018
PKFBICOC_01507	1499689.CCNN01000007_gene1847	5.6e-22	89.4	COG5566@1|root,COG5566@2|Bacteria,1VC4T@1239|Firmicutes,24NUM@186801|Clostridia,36VCM@31979|Clostridiaceae	186801|Clostridia	S	Mor transcription activator family	-	-	-	-	-	-	-	-	-	-	-	-	Mor
PKFBICOC_01509	742733.HMPREF9469_02885	9.35e-16	74.3	2EQRH@1|root,323WZ@2|Bacteria,1UQBG@1239|Firmicutes,25822@186801|Clostridia,222QT@1506553|Lachnoclostridium	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01510	411902.CLOBOL_06314	2.92e-47	159.0	28J2K@1|root,2Z8Z1@2|Bacteria,1UYFR@1239|Firmicutes,24IKK@186801|Clostridia,221M3@1506553|Lachnoclostridium	186801|Clostridia	S	Protein of unknown function (DUF3486)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3486
PKFBICOC_01513	693746.OBV_18030	2.02e-157	457.0	COG1783@1|root,COG1783@2|Bacteria,1TT2C@1239|Firmicutes,24A7T@186801|Clostridia,2N88R@216572|Oscillospiraceae	186801|Clostridia	S	Phage terminase large subunit	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_3C,Terminase_6,Terminase_6C
PKFBICOC_01514	411490.ANACAC_00782	3.12e-112	346.0	2BX0Z@1|root,2Z88Q@2|Bacteria,1UYMH@1239|Firmicutes,249U4@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Phage_prot_Gp6
PKFBICOC_01515	645991.Sgly_0338	3.74e-74	255.0	COG2369@1|root,COG2369@2|Bacteria,1UZ30@1239|Firmicutes,24D0A@186801|Clostridia	186801|Clostridia	M	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	ADPrib_exo_Tox,Phage_min_cap2
PKFBICOC_01517	1042156.CXIVA_00560	4.67e-21	84.3	2EC8I@1|root,33670@2|Bacteria,1VNEP@1239|Firmicutes,25DQM@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01518	1232449.BAHV02000010_gene2713	4.84e-09	60.8	2DQ5Z@1|root,334WJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GP20
PKFBICOC_01519	935836.JAEL01000021_gene1494	5.47e-120	355.0	2DBIJ@1|root,2Z9G2@2|Bacteria,1UXMJ@1239|Firmicutes,4HUNJ@91061|Bacilli,1ZH4G@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01522	883114.HMPREF9709_01190	3.83e-35	124.0	2C38D@1|root,3391N@2|Bacteria,1VIRX@1239|Firmicutes,25E0F@186801|Clostridia,22ISE@1570339|Peptoniphilaceae	186801|Clostridia	S	Minor capsid protein	-	-	-	-	-	-	-	-	-	-	-	-	Minor_capsid_2
PKFBICOC_01524	931276.Cspa_c07510	2.62e-53	173.0	2E26P@1|root,32XD4@2|Bacteria,1VDPV@1239|Firmicutes,24FU2@186801|Clostridia,36I7R@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01525	536233.CLO_1573	1.51e-16	77.0	2DK5T@1|root,308NQ@2|Bacteria,1VPRS@1239|Firmicutes,24PW2@186801|Clostridia,36KPN@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01526	411460.RUMTOR_02091	5.55e-32	121.0	2DJHU@1|root,32UD1@2|Bacteria,1V9ZS@1239|Firmicutes,24ECK@186801|Clostridia,3Y0TS@572511|Blautia	186801|Clostridia	S	COG NOG24969 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	Phage_Gp15
PKFBICOC_01528	536233.CLO_2822	3.98e-122	413.0	COG1196@1|root,COG5283@1|root,COG5412@1|root,COG1196@2|Bacteria,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,247QT@186801|Clostridia	186801|Clostridia	E	Phage tail tape measure protein, TP901 family	-	-	-	-	-	-	-	-	-	-	-	-	PhageMin_Tail
PKFBICOC_01529	411459.RUMOBE_00925	2.07e-12	72.4	COG4722@1|root,COG4722@2|Bacteria,1VB56@1239|Firmicutes,24P9X@186801|Clostridia	186801|Clostridia	S	phage tail	-	-	-	-	-	-	-	-	-	-	-	-	Sipho_tail
PKFBICOC_01530	903814.ELI_3101	5.21e-38	159.0	COG4926@1|root,COG4926@2|Bacteria,1TQHW@1239|Firmicutes,249SU@186801|Clostridia,25XMU@186806|Eubacteriaceae	186801|Clostridia	S	Phage minor structural protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74,Prophage_tail
PKFBICOC_01535	1511.CLOST_1503	1.13e-19	81.3	2EFVX@1|root,339N4@2|Bacteria,1VN74@1239|Firmicutes,24VSA@186801|Clostridia,25U6N@186804|Peptostreptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01536	696747.NIES39_A05270	1.07e-11	70.1	COG0791@1|root,COG0791@2|Bacteria,1G5E1@1117|Cyanobacteria,1HAUV@1150|Oscillatoriales	1117|Cyanobacteria	M	CHAP domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAP
PKFBICOC_01537	445972.ANACOL_00560	1.63e-77	241.0	COG0338@1|root,COG0338@2|Bacteria,1UBIY@1239|Firmicutes,248RN@186801|Clostridia,3WIFW@541000|Ruminococcaceae	186801|Clostridia	L	D12 class N6 adenine-specific DNA methyltransferase	dam	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
PKFBICOC_01538	931276.Cspa_c31510	1.63e-27	102.0	COG3655@1|root,COG3655@2|Bacteria,1VHK7@1239|Firmicutes,24R05@186801|Clostridia,36N4H@31979|Clostridiaceae	186801|Clostridia	K	Cro/C1-type HTH DNA-binding domain	-	-	-	ko:K07727	-	-	-	-	ko00000,ko03000	-	-	-	HTH_26
PKFBICOC_01539	665956.HMPREF1032_02805	7.94e-65	203.0	COG2606@1|root,COG2606@2|Bacteria,1V6JF@1239|Firmicutes,24I4E@186801|Clostridia,3WIUH@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	ybaK	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
PKFBICOC_01540	1123075.AUDP01000014_gene2999	1.47e-289	863.0	COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,3WGTT@541000|Ruminococcaceae	186801|Clostridia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	czcA	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
PKFBICOC_01541	1423734.JCM14202_3512	1.89e-17	84.7	COG1309@1|root,COG1309@2|Bacteria,1V6CF@1239|Firmicutes,4HJIC@91061|Bacilli,3FCEJ@33958|Lactobacillaceae	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
PKFBICOC_01542	411459.RUMOBE_00569	4.13e-61	192.0	COG0394@1|root,COG0394@2|Bacteria,1V6SG@1239|Firmicutes,24MMZ@186801|Clostridia,3Y08X@572511|Blautia	186801|Clostridia	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	yfkJ	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
PKFBICOC_01544	411463.EUBVEN_00676	3.44e-19	97.1	COG1372@1|root,COG1372@2|Bacteria,1V120@1239|Firmicutes,24CZG@186801|Clostridia	186801|Clostridia	L	SMART Hedgehog intein hint domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,WHH
PKFBICOC_01546	411463.EUBVEN_00676	5.64e-21	104.0	COG1372@1|root,COG1372@2|Bacteria,1V120@1239|Firmicutes,24CZG@186801|Clostridia	186801|Clostridia	L	SMART Hedgehog intein hint domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,WHH
PKFBICOC_01549	1392491.JIAE01000001_gene898	2.2e-27	105.0	2E7I7@1|root,3320M@2|Bacteria,1VIYI@1239|Firmicutes,24WZC@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01552	742765.HMPREF9457_02977	5.38e-24	102.0	COG0664@1|root,COG0664@2|Bacteria,1TSP9@1239|Firmicutes,24FRD@186801|Clostridia,27WBF@189330|Dorea	186801|Clostridia	K	COG COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
PKFBICOC_01553	658086.HMPREF0994_05067	9.93e-79	239.0	COG1971@1|root,COG1971@2|Bacteria,1V4QK@1239|Firmicutes,24FY0@186801|Clostridia,27MTS@186928|unclassified Lachnospiraceae	186801|Clostridia	P	Probably functions as a manganese efflux pump	mntP	-	-	-	-	-	-	-	-	-	-	-	Mntp
PKFBICOC_01554	428125.CLOLEP_02890	2.55e-139	405.0	COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,248DH@186801|Clostridia,3WH12@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the LDH MDH superfamily. LDH family	ldh	-	1.1.1.27	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	-	R00703,R01000,R03104	RC00031,RC00044	ko00000,ko00001,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
PKFBICOC_01555	641112.ACOK01000105_gene634	2.97e-155	441.0	COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,3WGGC@541000|Ruminococcaceae	186801|Clostridia	C	domain protein	nfnA	-	1.18.1.2,1.19.1.1	ko:K00528,ko:K16951	ko00920,ko01120,map00920,map01120	-	R00858,R10146,R10159	RC00065	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
PKFBICOC_01556	641112.ACOK01000105_gene633	1.73e-255	709.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3WGEA@541000|Ruminococcaceae	186801|Clostridia	C	glutamate synthase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
PKFBICOC_01557	1280679.ATVX01000008_gene2065	2.53e-136	406.0	COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia,4BW25@830|Butyrivibrio	186801|Clostridia	P	TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
PKFBICOC_01558	1160721.RBI_I00829	4.76e-188	540.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,3WGU8@541000|Ruminococcaceae	186801|Clostridia	P	Psort location CytoplasmicMembrane, score 10.00	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
PKFBICOC_01559	411489.CLOL250_02890	2.04e-21	102.0	COG0860@1|root,COG0860@2|Bacteria,1TSFS@1239|Firmicutes,2488U@186801|Clostridia,36F21@31979|Clostridiaceae	186801|Clostridia	M	stage II sporulation protein P	spoIIP	-	-	ko:K06385	-	-	-	-	ko00000	-	-	-	SpoIIP
PKFBICOC_01560	428125.CLOLEP_02521	2.35e-108	323.0	COG0680@1|root,COG0680@2|Bacteria,1TPFY@1239|Firmicutes,248TE@186801|Clostridia,3WGVA@541000|Ruminococcaceae	186801|Clostridia	C	Initiates the rapid degradation of small, acid-soluble proteins during spore germination	gpr	-	3.4.24.78	ko:K06012	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_A25
PKFBICOC_01561	1151292.QEW_3406	5.79e-53	200.0	COG2247@1|root,COG4870@1|root,COG2247@2|Bacteria,COG4870@2|Bacteria,1TVCW@1239|Firmicutes,25B7E@186801|Clostridia,25S9K@186804|Peptostreptococcaceae	186801|Clostridia	M	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,CW_binding_2,Flg_new,Peptidase_C1
PKFBICOC_01562	428125.CLOLEP_03258	4.51e-207	586.0	COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,247X2@186801|Clostridia,3WGT0@541000|Ruminococcaceae	186801|Clostridia	L	ATPase, AAA family	yrvN	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
PKFBICOC_01563	1214166.ALLG01000001_gene1573	5.46e-12	77.8	COG0366@1|root,COG5492@1|root,COG0366@2|Bacteria,COG5492@2|Bacteria,1V0U1@1239|Firmicutes,4HV3E@91061|Bacilli	91061|Bacilli	G	alpha-amylase	aml1	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM26,CBM53,CBM_35,CHB_HEX_C_1
PKFBICOC_01564	1449050.JNLE01000003_gene2028	6.03e-218	645.0	COG0366@1|root,COG3291@1|root,COG0366@2|Bacteria,COG3291@2|Bacteria,1V0U1@1239|Firmicutes,24ZQ4@186801|Clostridia	186801|Clostridia	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
PKFBICOC_01566	1340434.AXVA01000004_gene2579	4.21e-05	48.9	COG0454@1|root,COG0454@2|Bacteria,1V78S@1239|Firmicutes,4HJMM@91061|Bacilli,1ZIJF@1386|Bacillus	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
PKFBICOC_01567	1345695.CLSA_c26760	2.77e-11	64.3	2DETX@1|root,2ZP8Z@2|Bacteria,1W4UB@1239|Firmicutes,24VW4@186801|Clostridia	186801|Clostridia	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_36
PKFBICOC_01568	1089550.ATTH01000001_gene2110	4.5e-34	120.0	COG3118@1|root,COG3118@2|Bacteria,4NQ5B@976|Bacteroidetes,1FJEP@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
PKFBICOC_01569	1160721.RBI_II00396	1.66e-17	81.6	2EQ5U@1|root,33HS4@2|Bacteria,1V3H5@1239|Firmicutes,24VF0@186801|Clostridia,3WKPZ@541000|Ruminococcaceae	186801|Clostridia	S	Terminase small subunit	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_2
PKFBICOC_01570	1121334.KB911067_gene273	8.79e-201	568.0	COG1783@1|root,COG1783@2|Bacteria,1TT2C@1239|Firmicutes,24A7T@186801|Clostridia,3WHDS@541000|Ruminococcaceae	186801|Clostridia	S	Phage terminase, large subunit, PBSX family	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
PKFBICOC_01571	1105031.HMPREF1141_0089	1.96e-106	325.0	28KHP@1|root,2ZA34@2|Bacteria,1TQEJ@1239|Firmicutes,249F6@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Phage_portal
PKFBICOC_01572	428125.CLOLEP_03662	3.57e-81	256.0	28MWX@1|root,2ZB45@2|Bacteria,1UZ34@1239|Firmicutes,24EV8@186801|Clostridia,3WIEZ@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01574	411467.BACCAP_00296	1.24e-141	411.0	28IS3@1|root,2Z8R9@2|Bacteria,1TSHH@1239|Firmicutes,24CQ6@186801|Clostridia,268KW@186813|unclassified Clostridiales	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Phage_capsid
PKFBICOC_01584	1007096.BAGW01000017_gene812	7.9e-50	177.0	COG3299@1|root,COG3299@2|Bacteria,1UYY1@1239|Firmicutes,24FCN@186801|Clostridia,2N6VA@216572|Oscillospiraceae	186801|Clostridia	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
PKFBICOC_01586	585501.HMPREF6123_1456	3.85e-274	758.0	COG1672@1|root,COG1672@2|Bacteria,1TR21@1239|Firmicutes,24ADD@186801|Clostridia,2PQYT@265975|Oribacterium	186801|Clostridia	S	cog cog1672	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2,DUF234
PKFBICOC_01587	1235802.C823_04981	0.0	1542.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,25VEG@186806|Eubacteriaceae	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
PKFBICOC_01588	941824.TCEL_02147	5.82e-65	216.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,36EN8@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
PKFBICOC_01589	1120746.CCNL01000017_gene3207	1.74e-171	485.0	COG0462@1|root,COG0462@2|Bacteria,2NNP6@2323|unclassified Bacteria	2|Bacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2848	Pribosyl_synth,Pribosyltran_N
PKFBICOC_01590	457421.CBFG_05521	6.09e-68	227.0	28JZ6@1|root,2Z9PA@2|Bacteria,1UQ35@1239|Firmicutes,24F3U@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01591	1514668.JOOA01000002_gene2338	1.25e-85	258.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,3WIEP@541000|Ruminococcaceae	186801|Clostridia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
PKFBICOC_01592	428125.CLOLEP_00295	0.0	1333.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,3WGVW@541000|Ruminococcaceae	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
PKFBICOC_01595	1158607.UAU_04291	2.56e-05	45.4	COG4224@1|root,COG4224@2|Bacteria,1VEKJ@1239|Firmicutes,4HNIB@91061|Bacilli,4B3FF@81852|Enterococcaceae	91061|Bacilli	S	Bacterial protein of unknown function (DUF896)	ynzC	-	-	-	-	-	-	-	-	-	-	-	DUF896
PKFBICOC_01596	1384066.JAGT01000001_gene320	1.11e-129	398.0	COG0249@1|root,COG0249@2|Bacteria,1UYBJ@1239|Firmicutes,249T9@186801|Clostridia,3WSH2@541000|Ruminococcaceae	186801|Clostridia	L	ATPase domain of DNA mismatch repair MUTS family	-	-	-	-	-	-	-	-	-	-	-	-	MutS_V
PKFBICOC_01597	318464.IO99_13040	5.22e-85	265.0	COG0679@1|root,COG0679@2|Bacteria,1TR9W@1239|Firmicutes,24AQF@186801|Clostridia,36FZA@31979|Clostridiaceae	186801|Clostridia	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
PKFBICOC_01599	1378168.N510_00350	6.17e-28	102.0	COG2155@1|root,COG2155@2|Bacteria,1VEQJ@1239|Firmicutes	1239|Firmicutes	S	Conserved protein	yuzA	-	-	ko:K09779	-	-	-	-	ko00000	-	-	-	DUF378
PKFBICOC_01600	428125.CLOLEP_03328	1.64e-185	527.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,3WH48@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
PKFBICOC_01601	1122217.KB899572_gene1163	1.96e-49	179.0	COG1323@1|root,COG1323@2|Bacteria,1TPP2@1239|Firmicutes,4H3EU@909932|Negativicutes	909932|Negativicutes	S	Belongs to the UPF0348 family	-	-	-	-	-	-	-	-	-	-	-	-	HIGH_NTase1
PKFBICOC_01603	203119.Cthe_0423	0.0	1391.0	COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,3WHK1@541000|Ruminococcaceae	186801|Clostridia	C	belongs to the iron- containing alcohol dehydrogenase family	adhE	-	1.1.1.1,1.2.1.10	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
PKFBICOC_01604	1280390.CBQR020000120_gene3147	2.08e-112	330.0	COG0510@1|root,COG0510@2|Bacteria,1TQW6@1239|Firmicutes,4HC1S@91061|Bacilli	91061|Bacilli	M	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
PKFBICOC_01605	767817.Desgi_3550	4.67e-07	60.8	COG0791@1|root,COG0791@2|Bacteria,1VS0A@1239|Firmicutes,24CV4@186801|Clostridia,264BM@186807|Peptococcaceae	186801|Clostridia	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01607	515622.bpr_I0245	3.18e-52	194.0	COG2208@1|root,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,249WB@186801|Clostridia,4BWYS@830|Butyrivibrio	186801|Clostridia	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE,dCache_1
PKFBICOC_01608	641112.ACOK01000025_gene2768	6.54e-192	541.0	COG0037@1|root,COG0607@1|root,COG0037@2|Bacteria,COG0607@2|Bacteria,1TQ0Y@1239|Firmicutes,247RP@186801|Clostridia,3WGZH@541000|Ruminococcaceae	186801|Clostridia	D	Belongs to the TtcA family	ttcA	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3,Rhodanese
PKFBICOC_01610	1514668.JOOA01000002_gene1442	1.95e-21	89.7	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,25KIW@186801|Clostridia,3WMDA@541000|Ruminococcaceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
PKFBICOC_01613	428125.CLOLEP_03941	0.0	1956.0	COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,3WH6H@541000|Ruminococcaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
PKFBICOC_01614	428125.CLOLEP_03943	0.0	1875.0	COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,3WGVS@541000|Ruminococcaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
PKFBICOC_01615	1160721.RBI_I00132	9.52e-25	94.0	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,252JX@186801|Clostridia,3WKI0@541000|Ruminococcaceae	186801|Clostridia	K	Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
PKFBICOC_01616	1121334.KB911067_gene255	6.99e-51	166.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,3WJ8E@541000|Ruminococcaceae	186801|Clostridia	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
PKFBICOC_01617	428125.CLOLEP_02533	6e-185	555.0	COG2208@1|root,COG2208@2|Bacteria,1TQ92@1239|Firmicutes,247XG@186801|Clostridia,3WH68@541000|Ruminococcaceae	186801|Clostridia	KT	stage II sporulation protein E	spoIIE	-	3.1.3.16	ko:K06382	-	-	-	-	ko00000,ko01000	-	-	-	SpoIIE
PKFBICOC_01618	1280686.AUKE01000008_gene2622	5.97e-15	82.8	2DWQB@1|root,341EH@2|Bacteria,1VX2Y@1239|Firmicutes,25AYC@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01619	764299.STRIC_1753	0.000624	42.7	COG1476@1|root,COG1476@2|Bacteria,1VEGF@1239|Firmicutes,4HNVM@91061|Bacilli	91061|Bacilli	K	Transcriptional	lanR	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
PKFBICOC_01620	1235799.C818_03247	3.01e-204	567.0	COG3177@1|root,COG3177@2|Bacteria,1V3AX@1239|Firmicutes,248VF@186801|Clostridia,27NE7@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
PKFBICOC_01622	428125.CLOLEP_01062	1.1e-210	593.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,3WK6T@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
PKFBICOC_01623	931276.Cspa_c25100	2.9e-36	129.0	COG3467@1|root,COG3467@2|Bacteria,1V7MR@1239|Firmicutes,25B09@186801|Clostridia,36W93@31979|Clostridiaceae	186801|Clostridia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
PKFBICOC_01624	457570.Nther_2650	6.07e-11	70.9	COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia	186801|Clostridia	EJ	L-asparaginase	ansA	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
PKFBICOC_01625	1226325.HMPREF1548_04814	5.66e-155	451.0	COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia,36DM6@31979|Clostridiaceae	186801|Clostridia	P	Transporter, CPA2 family	napA	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
PKFBICOC_01626	290402.Cbei_0271	0.000102	49.3	COG1309@1|root,COG1309@2|Bacteria,1V59K@1239|Firmicutes,24BGP@186801|Clostridia,36HTF@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_8,TetR_N
PKFBICOC_01627	1121334.KB911072_gene2601	3.2e-286	807.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,3WGDM@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
PKFBICOC_01628	1232453.BAIF02000102_gene3673	3.94e-36	149.0	2AHKI@1|root,317YB@2|Bacteria,1V965@1239|Firmicutes,24MIW@186801|Clostridia,26BP7@186813|unclassified Clostridiales	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
PKFBICOC_01629	545694.TREPR_3601	5.97e-18	90.1	COG1752@1|root,COG1752@2|Bacteria,2J6JW@203691|Spirochaetes	203691|Spirochaetes	M	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,Patatin
PKFBICOC_01630	698758.AXY_19270	5.2e-41	145.0	28JM5@1|root,2Z9DQ@2|Bacteria,1TS2D@1239|Firmicutes,4HRPU@91061|Bacilli	91061|Bacilli	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01631	643648.Slip_2351	8.88e-17	73.6	COG4481@1|root,COG4481@2|Bacteria,1VEQ7@1239|Firmicutes,24QKA@186801|Clostridia,42K83@68298|Syntrophomonadaceae	186801|Clostridia	S	Bacterial protein of unknown function (DUF951)	-	-	-	-	-	-	-	-	-	-	-	-	DUF951
PKFBICOC_01632	428125.CLOLEP_03918	6.51e-177	502.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,3WGA4@541000|Ruminococcaceae	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
PKFBICOC_01633	428125.CLOLEP_03920	1.01e-134	394.0	COG0009@1|root,COG0009@2|Bacteria,1TP1I@1239|Firmicutes,248HS@186801|Clostridia,3WGIY@541000|Ruminococcaceae	186801|Clostridia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
PKFBICOC_01634	1484460.JSWG01000015_gene1099	1.72e-15	79.0	COG0237@1|root,COG0237@2|Bacteria,4NQKS@976|Bacteroidetes,1I1XH@117743|Flavobacteriia	976|Bacteroidetes	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
PKFBICOC_01635	1096546.WYO_0710	7e-11	68.9	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2TRDB@28211|Alphaproteobacteria,1JRDW@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	PFAM Lytic transglycosylase catalytic	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
PKFBICOC_01636	428125.CLOLEP_03923	4.62e-229	643.0	COG1362@1|root,COG1362@2|Bacteria,1TP6G@1239|Firmicutes,2486Y@186801|Clostridia,3WHAH@541000|Ruminococcaceae	186801|Clostridia	E	M18 family aminopeptidase	apeA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M18
PKFBICOC_01638	749222.Nitsa_1646	2.37e-24	97.8	2CCSR@1|root,32RWC@2|Bacteria,1MZFP@1224|Proteobacteria,42U6B@68525|delta/epsilon subdivisions,2YQ44@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
PKFBICOC_01639	931626.Awo_c23170	2.81e-29	126.0	COG3942@1|root,COG3942@2|Bacteria,1VFAV@1239|Firmicutes,25BXN@186801|Clostridia	186801|Clostridia	N	CHAP domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CHAP,CW_binding_1,GBS_Bsp-like,RicinB_lectin_2
PKFBICOC_01640	1235793.C809_04307	1.77e-82	267.0	COG3290@1|root,COG3290@2|Bacteria,1V0KZ@1239|Firmicutes,25BG0@186801|Clostridia,27TX7@186928|unclassified Lachnospiraceae	186801|Clostridia	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_5
PKFBICOC_01641	478749.BRYFOR_09532	4.07e-18	89.4	COG3279@1|root,COG3279@2|Bacteria,1V7ED@1239|Firmicutes,24K36@186801|Clostridia	186801|Clostridia	T	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
PKFBICOC_01643	411463.EUBVEN_02823	2.73e-100	304.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia,25VNT@186806|Eubacteriaceae	186801|Clostridia	C	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	hprA	-	1.1.1.29,1.1.1.399,1.1.1.95	ko:K00018,ko:K00058	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020,M00346	R00717,R01388,R01513	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
PKFBICOC_01644	471875.RUMLAC_01710	6.17e-56	186.0	COG0546@1|root,COG0546@2|Bacteria,1V3MH@1239|Firmicutes,25F06@186801|Clostridia	186801|Clostridia	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
PKFBICOC_01645	428125.CLOLEP_01772	0.0	1850.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,3WGRN@541000|Ruminococcaceae	186801|Clostridia	F	phosphoribosylformylglycinamidine synthase	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
PKFBICOC_01647	1216362.B437_07212	6.15e-54	183.0	COG4185@1|root,COG4185@2|Bacteria,378KI@32066|Fusobacteria	32066|Fusobacteria	S	Zeta toxin	-	-	2.7.1.176	ko:K16214	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Zeta_toxin
PKFBICOC_01648	1410661.JNKW01000002_gene1616	2.08e-71	231.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
PKFBICOC_01649	1410638.JHXJ01000016_gene228	1.17e-37	136.0	COG4684@1|root,COG4684@2|Bacteria,1V2M1@1239|Firmicutes,249YQ@186801|Clostridia,3WK03@541000|Ruminococcaceae	186801|Clostridia	S	ECF transporter, substrate-specific component	-	-	-	-	-	-	-	-	-	-	-	-	ECF_trnsprt
PKFBICOC_01650	428125.CLOLEP_02571	4.58e-84	258.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,3WHZV@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
PKFBICOC_01651	1120746.CCNL01000008_gene578	2.11e-138	397.0	COG3959@1|root,COG3959@2|Bacteria,2NP12@2323|unclassified Bacteria	2|Bacteria	G	Transketolase, thiamine diphosphate binding domain	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
PKFBICOC_01652	1120746.CCNL01000008_gene579	1.91e-157	449.0	COG3958@1|root,COG3958@2|Bacteria,2NQFH@2323|unclassified Bacteria	2|Bacteria	G	Transketolase, pyrimidine binding domain	tklB	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
PKFBICOC_01654	428125.CLOLEP_03768	1.35e-207	580.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,3WG9I@541000|Ruminococcaceae	186801|Clostridia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
PKFBICOC_01655	756499.Desde_2535	4.59e-18	81.3	COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,24MWR@186801|Clostridia,262M7@186807|Peptococcaceae	186801|Clostridia	S	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
PKFBICOC_01656	411461.DORFOR_01437	3.25e-41	146.0	COG0546@1|root,COG0546@2|Bacteria,1V1FQ@1239|Firmicutes,24G1U@186801|Clostridia,27VI1@189330|Dorea	186801|Clostridia	S	HAD-hyrolase-like	nt5e	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
PKFBICOC_01658	537013.CLOSTMETH_01071	4.41e-70	222.0	COG1187@1|root,COG1187@2|Bacteria,1TQZ2@1239|Firmicutes,248HC@186801|Clostridia,3WHTI@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rsuA	-	5.4.99.19	ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
PKFBICOC_01659	1120746.CCNL01000017_gene3154	2.19e-204	572.0	COG3842@1|root,COG3842@2|Bacteria,2NNU0@2323|unclassified Bacteria	2|Bacteria	E	ATPases associated with a variety of cellular activities	msmX	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
PKFBICOC_01660	428125.CLOLEP_01620	3.19e-216	602.0	COG3835@1|root,COG3835@2|Bacteria,1TQWD@1239|Firmicutes,24ZMW@186801|Clostridia,3WHDV@541000|Ruminococcaceae	186801|Clostridia	KT	Psort location Cytoplasmic, score	-	-	-	ko:K02647	-	-	-	-	ko00000,ko03000	-	-	-	Diacid_rec,HTH_30
PKFBICOC_01661	1507.HMPREF0262_03282	1.05e-96	289.0	COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,36DHJ@31979|Clostridiaceae	186801|Clostridia	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
PKFBICOC_01662	1120746.CCNL01000017_gene3151	1.26e-90	278.0	COG2177@1|root,COG2177@2|Bacteria	2|Bacteria	D	cell division	ftsX	GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009274,GO:0009276,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0032506,GO:0034097,GO:0040007,GO:0042173,GO:0042221,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0090529,GO:1902531	-	ko:K09811,ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
PKFBICOC_01663	428125.CLOLEP_01623	6.48e-53	191.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,3WGCB@541000|Ruminococcaceae	186801|Clostridia	D	Peptidase, M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
PKFBICOC_01665	1120746.CCNL01000017_gene3148	8.5e-50	164.0	COG0782@1|root,COG0782@2|Bacteria,2NPT2@2323|unclassified Bacteria	2|Bacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624,ko:K06140	-	-	-	-	ko00000,ko03000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
PKFBICOC_01666	478749.BRYFOR_06776	0.0	969.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
PKFBICOC_01667	411463.EUBVEN_02147	1.11e-299	820.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,25VVF@186806|Eubacteriaceae	186801|Clostridia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
PKFBICOC_01668	1121334.KB911070_gene1301	3.54e-27	105.0	COG3679@1|root,COG3679@2|Bacteria,1VDFJ@1239|Firmicutes,24MY6@186801|Clostridia,3WJJP@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the UPF0342 family	-	-	-	-	-	-	-	-	-	-	-	-	Com_YlbF
PKFBICOC_01669	1120746.CCNL01000011_gene1865	3.29e-231	649.0	COG0621@1|root,COG0621@2|Bacteria,2NNUN@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
PKFBICOC_01670	537013.CLOSTMETH_02581	7.23e-24	102.0	2B51H@1|root,31XUS@2|Bacteria,1V6KA@1239|Firmicutes,24JQP@186801|Clostridia,3WKHP@541000|Ruminococcaceae	186801|Clostridia	S	sporulation protein YunB	yunB	-	-	-	-	-	-	-	-	-	-	-	Spore_YunB
PKFBICOC_01671	1105031.HMPREF1141_0769	4.91e-28	108.0	2E3FE@1|root,32YE8@2|Bacteria,1VFR0@1239|Firmicutes,24MNV@186801|Clostridia,36W39@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01672	1105031.HMPREF1141_0768	8.22e-120	343.0	COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,249DV@186801|Clostridia,36DS4@31979|Clostridiaceae	186801|Clostridia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
PKFBICOC_01673	697284.ERIC2_c33050	2.2e-84	267.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,4HAT7@91061|Bacilli,26QP9@186822|Paenibacillaceae	91061|Bacilli	E	Xaa-Pro dipeptidase	yqhT	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
PKFBICOC_01674	1120746.CCNL01000011_gene1643	2.91e-75	227.0	COG0757@1|root,COG0757@2|Bacteria,2NPMW@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0349	DHquinase_II
PKFBICOC_01675	720554.Clocl_2790	1.03e-22	88.2	COG0828@1|root,COG0828@2|Bacteria,1VEHU@1239|Firmicutes,24QP9@186801|Clostridia,3WKHJ@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
PKFBICOC_01676	1120746.CCNL01000012_gene1931	0.0	1351.0	COG0495@1|root,COG0495@2|Bacteria,2NNQH@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
PKFBICOC_01677	1105031.HMPREF1141_2678	3.75e-38	131.0	COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,24MVA@186801|Clostridia,36KHS@31979|Clostridiaceae	186801|Clostridia	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
PKFBICOC_01678	235909.GK2521	5.14e-39	139.0	COG1713@1|root,COG1713@2|Bacteria,1V6Y1@1239|Firmicutes,4HHRY@91061|Bacilli,1WFI5@129337|Geobacillus	91061|Bacilli	H	Metal dependent phosphohydrolases with conserved 'HD' motif.	yqeK	-	-	-	-	-	-	-	-	-	-	-	HD
PKFBICOC_01679	338963.Pcar_2578	2.4e-29	115.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,42SD9@68525|delta/epsilon subdivisions,2WPPN@28221|Deltaproteobacteria,43TRZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Cytidylyltransferase-like	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3200	CTP_transf_like
PKFBICOC_01680	1410670.JHXF01000009_gene296	4.68e-33	117.0	COG1534@1|root,COG1534@2|Bacteria,1VEGM@1239|Firmicutes,24QZB@186801|Clostridia,3WKIM@541000|Ruminococcaceae	186801|Clostridia	J	RNA-binding protein, YhbY family	yhbY	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
PKFBICOC_01681	1514668.JOOA01000002_gene3188	9.11e-64	202.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,3WIUM@541000|Ruminococcaceae	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
PKFBICOC_01682	428125.CLOLEP_03292	3.52e-157	447.0	COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia,3WGFT@541000|Ruminococcaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
PKFBICOC_01683	1120746.CCNL01000012_gene1938	0.0	991.0	COG1196@1|root,COG1196@2|Bacteria,2NNYZ@2323|unclassified Bacteria	2|Bacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
PKFBICOC_01684	246199.CUS_7441	1.49e-90	283.0	COG1243@1|root,COG1243@2|Bacteria,1TS1F@1239|Firmicutes,248YV@186801|Clostridia,3WGUJ@541000|Ruminococcaceae	186801|Clostridia	BK	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,Radical_SAM_C
PKFBICOC_01685	428125.CLOLEP_03295	8.05e-108	317.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,3WG7D@541000|Ruminococcaceae	186801|Clostridia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
PKFBICOC_01686	1105031.HMPREF1141_2669	8.96e-134	390.0	COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia,36E96@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
PKFBICOC_01687	1120746.CCNL01000012_gene1942	1.84e-211	596.0	COG1206@1|root,COG1206@2|Bacteria,2NS4B@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
PKFBICOC_01688	428125.CLOLEP_03298	0.0	926.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,3WGDZ@541000|Ruminococcaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
PKFBICOC_01689	935948.KE386494_gene301	2.14e-43	162.0	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,42FQZ@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
PKFBICOC_01690	428125.CLOLEP_03300	4.51e-83	256.0	COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,248DV@186801|Clostridia,3WIQ9@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
PKFBICOC_01691	428125.CLOLEP_03301	2.22e-66	202.0	COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia,3WIYY@541000|Ruminococcaceae	186801|Clostridia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
PKFBICOC_01692	428125.CLOLEP_03302	5.89e-34	117.0	COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia,3WKKQ@541000|Ruminococcaceae	186801|Clostridia	J	Ribosomal protein L35	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
PKFBICOC_01693	428125.CLOLEP_03303	4.52e-97	286.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,3WIZW@541000|Ruminococcaceae	186801|Clostridia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
PKFBICOC_01694	428125.CLOLEP_02105	2.26e-141	408.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,3WGCR@541000|Ruminococcaceae	186801|Clostridia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
PKFBICOC_01695	428125.CLOLEP_02104	1.51e-144	410.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia,3WGT4@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
PKFBICOC_01697	663278.Ethha_1626	9.46e-17	75.9	COG1873@1|root,COG1873@2|Bacteria,1VGWH@1239|Firmicutes,259AU@186801|Clostridia,3WKPN@541000|Ruminococcaceae	186801|Clostridia	S	sporulation protein, YlmC YmxH family	-	-	-	-	-	-	-	-	-	-	-	-	PRC
PKFBICOC_01698	318464.IO99_15925	6.85e-98	296.0	COG1307@1|root,COG1307@2|Bacteria,1TQDI@1239|Firmicutes,24ADT@186801|Clostridia,36EZJ@31979|Clostridiaceae	186801|Clostridia	S	DegV family	-	-	-	-	-	-	-	-	-	-	-	-	DegV
PKFBICOC_01699	1120746.CCNL01000011_gene1798	6.17e-41	149.0	2APHB@1|root,31EKA@2|Bacteria,2NRSM@2323|unclassified Bacteria	2|Bacteria	S	Sporulation factor SpoIIGA	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_U4
PKFBICOC_01700	428125.CLOLEP_02097	1.29e-109	321.0	COG1191@1|root,COG1191@2|Bacteria,1TP3T@1239|Firmicutes,24A4T@186801|Clostridia,3WGM5@541000|Ruminococcaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigE	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
PKFBICOC_01702	1120746.CCNL01000010_gene1198	1.01e-53	182.0	COG0668@1|root,COG0668@2|Bacteria,2NP91@2323|unclassified Bacteria	2|Bacteria	M	Mechanosensitive ion channel	mscS	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022607,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055082,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
PKFBICOC_01704	428125.CLOLEP_00557	1.46e-165	471.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia,3WH67@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
PKFBICOC_01705	1280673.AUJJ01000011_gene1980	4.02e-145	419.0	COG0463@1|root,COG0463@2|Bacteria,1TPR3@1239|Firmicutes,248Q5@186801|Clostridia,4BYPC@830|Butyrivibrio	186801|Clostridia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
PKFBICOC_01707	500632.CLONEX_00165	8.25e-102	329.0	COG3274@1|root,COG3274@2|Bacteria,1UYCP@1239|Firmicutes,24FH8@186801|Clostridia	186801|Clostridia	S	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
PKFBICOC_01708	428125.CLOLEP_00237	8.1e-251	707.0	COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,3WGEY@541000|Ruminococcaceae	186801|Clostridia	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain	pgcA	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
PKFBICOC_01709	1235797.C816_02156	2.01e-68	214.0	COG1247@1|root,COG1247@2|Bacteria,1V6X5@1239|Firmicutes,24IB5@186801|Clostridia,2N7A2@216572|Oscillospiraceae	186801|Clostridia	M	Acetyltransferase (GNAT) domain	pat	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
PKFBICOC_01710	1286171.EAL2_c20090	6.36e-39	152.0	COG3475@1|root,COG3475@2|Bacteria,1VBSV@1239|Firmicutes,24C5H@186801|Clostridia,25X1J@186806|Eubacteriaceae	186801|Clostridia	M	LicD family	-	-	-	ko:K07271	-	-	-	-	ko00000,ko01000	-	-	-	LicD
PKFBICOC_01711	877411.JMMA01000002_gene2599	3.94e-158	454.0	COG0451@1|root,COG0451@2|Bacteria,1TS59@1239|Firmicutes,247JP@186801|Clostridia,3WJ79@541000|Ruminococcaceae	186801|Clostridia	GM	epimerase dehydratase	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
PKFBICOC_01712	877411.JMMA01000002_gene2598	3.3e-156	440.0	COG1211@1|root,COG1211@2|Bacteria,1TS1B@1239|Firmicutes,2484P@186801|Clostridia,3WJ9I@541000|Ruminococcaceae	186801|Clostridia	I	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
PKFBICOC_01713	1410670.JHXF01000010_gene522	2.15e-145	422.0	COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia,3WG83@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N,PyrI_C
PKFBICOC_01714	1410630.JNKP01000001_gene1813	2.05e-05	51.6	COG3247@1|root,COG3247@2|Bacteria,1VFKP@1239|Firmicutes,24RBX@186801|Clostridia,27NK8@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
PKFBICOC_01715	1121334.KB911069_gene1504	1.73e-277	821.0	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,3WGE1@541000|Ruminococcaceae	186801|Clostridia	L	ATP-dependent helicase nuclease subunit A	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
PKFBICOC_01716	428125.CLOLEP_03305	2.24e-251	749.0	COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia,3WG8U@541000|Ruminococcaceae	186801|Clostridia	L	ATP-dependent helicase deoxyribonuclease subunit B	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
PKFBICOC_01717	411460.RUMTOR_02734	4.15e-36	133.0	2AUKD@1|root,31K93@2|Bacteria,1V6PK@1239|Firmicutes,24J91@186801|Clostridia,3Y092@572511|Blautia	186801|Clostridia	S	Stage II sporulation protein R (spore_II_R)	spoIIR	-	-	ko:K06387	-	-	-	-	ko00000	-	-	-	Spore_II_R
PKFBICOC_01718	521460.Athe_1538	3.12e-54	184.0	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,42GD3@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
PKFBICOC_01719	428125.CLOLEP_03309	2.56e-209	587.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,3WGAJ@541000|Ruminococcaceae	186801|Clostridia	E	Aminotransferase	aspC	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
PKFBICOC_01720	1444309.JAQG01000172_gene446	1.84e-36	130.0	COG1522@1|root,COG1522@2|Bacteria,1V3PB@1239|Firmicutes,4HH9K@91061|Bacilli,26RX2@186822|Paenibacillaceae	91061|Bacilli	K	AsnC family transcriptional regulator	alaR	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
PKFBICOC_01722	641112.ACOK01000112_gene2108	5.67e-283	793.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,3WH2R@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
PKFBICOC_01723	428125.CLOLEP_01530	1.23e-49	185.0	COG3307@1|root,COG3307@2|Bacteria,1VK2G@1239|Firmicutes,24S8D@186801|Clostridia	186801|Clostridia	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
PKFBICOC_01724	411459.RUMOBE_02905	2.24e-79	244.0	COG2148@1|root,COG2148@2|Bacteria,1TP7V@1239|Firmicutes,25AZD@186801|Clostridia,3Y00N@572511|Blautia	186801|Clostridia	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
PKFBICOC_01725	1121334.KB911074_gene2538	3.9e-30	110.0	COG3906@1|root,COG3906@2|Bacteria,1VF5Z@1239|Firmicutes,24V04@186801|Clostridia	186801|Clostridia	S	Belongs to the UPF0473 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1292
PKFBICOC_01726	357809.Cphy_3205	1.07e-130	382.0	COG0240@1|root,COG0240@2|Bacteria,1TQ5P@1239|Firmicutes,248JT@186801|Clostridia,21Z7T@1506553|Lachnoclostridium	186801|Clostridia	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
PKFBICOC_01727	1280673.AUJJ01000009_gene2990	6.97e-34	143.0	2A1D0@1|root,30PK1@2|Bacteria,1UKEI@1239|Firmicutes,25G46@186801|Clostridia,4C2AI@830|Butyrivibrio	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01728	521003.COLINT_02710	5.26e-36	138.0	COG1307@1|root,COG1307@2|Bacteria,2GIUV@201174|Actinobacteria,4CVJC@84998|Coriobacteriia	84998|Coriobacteriia	S	EDD domain protein, DegV family	-	-	-	-	-	-	-	-	-	-	-	-	DegV
PKFBICOC_01729	485916.Dtox_2894	4.38e-57	199.0	28NW3@1|root,2ZBU0@2|Bacteria,1V2IM@1239|Firmicutes,24GA1@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
PKFBICOC_01730	665950.HMPREF1025_02156	2.15e-23	96.7	COG0681@1|root,COG0681@2|Bacteria,1VFKY@1239|Firmicutes,24RQG@186801|Clostridia,27SM3@186928|unclassified Lachnospiraceae	186801|Clostridia	U	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
PKFBICOC_01731	658088.HMPREF0987_00084	4.93e-20	83.6	2E5V7@1|root,330JA@2|Bacteria,1VFNT@1239|Firmicutes,24RD2@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
PKFBICOC_01732	428125.CLOLEP_02071	1.32e-297	823.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,3WGUG@541000|Ruminococcaceae	186801|Clostridia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
PKFBICOC_01733	537013.CLOSTMETH_00658	6.1e-40	134.0	COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,24MMM@186801|Clostridia,3WJT1@541000|Ruminococcaceae	186801|Clostridia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
PKFBICOC_01734	1120746.CCNL01000014_gene2042	6.39e-105	333.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria	2|Bacteria	G	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,TIR_2
PKFBICOC_01736	1291050.JAGE01000002_gene3742	4.47e-23	99.4	COG1564@1|root,COG1564@2|Bacteria,1VA0W@1239|Firmicutes,24NG6@186801|Clostridia,3WJUT@541000|Ruminococcaceae	186801|Clostridia	H	thiamine pyrophosphokinase	thiN	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
PKFBICOC_01737	428125.CLOLEP_02345	4.21e-109	325.0	COG1162@1|root,COG1162@2|Bacteria,1TPSQ@1239|Firmicutes,248R5@186801|Clostridia,3WGGY@541000|Ruminococcaceae	186801|Clostridia	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
PKFBICOC_01738	1121334.KB911066_gene645	2.25e-220	638.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3WGK8@541000|Ruminococcaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
PKFBICOC_01739	1380390.JIAT01000009_gene1779	6.87e-41	152.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4CQ6E@84995|Rubrobacteria	84995|Rubrobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
PKFBICOC_01740	428125.CLOLEP_02342	5.63e-152	438.0	COG0820@1|root,COG0820@2|Bacteria,1TPVF@1239|Firmicutes,248BC@186801|Clostridia,3WGYF@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
PKFBICOC_01741	1304284.L21TH_0671	3.25e-109	337.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,36DEN@31979|Clostridiaceae	186801|Clostridia	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
PKFBICOC_01742	1203606.HMPREF1526_00451	5.27e-74	231.0	COG2738@1|root,COG2738@2|Bacteria,1TPD3@1239|Firmicutes,2490Y@186801|Clostridia,36FA7@31979|Clostridiaceae	186801|Clostridia	S	zinc metallopeptidase	yugP	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
PKFBICOC_01743	883156.HMPREF9282_01919	2.85e-95	291.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,4H2M2@909932|Negativicutes	909932|Negativicutes	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
PKFBICOC_01744	1507.HMPREF0262_02227	1.56e-60	191.0	COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,24JET@186801|Clostridia,36IPZ@31979|Clostridiaceae	186801|Clostridia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
PKFBICOC_01745	428125.CLOLEP_02337	0.0	912.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,3WGTG@541000|Ruminococcaceae	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
PKFBICOC_01747	1229172.JQFA01000004_gene1565	2.45e-50	168.0	COG0194@1|root,COG0194@2|Bacteria,1G515@1117|Cyanobacteria,1HAKW@1150|Oscillatoriales	1117|Cyanobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
PKFBICOC_01748	1514668.JOOA01000002_gene2086	1.14e-24	95.1	COG2052@1|root,COG2052@2|Bacteria,1VA40@1239|Firmicutes,24MXV@186801|Clostridia,3WJWB@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the UPF0296 family	NPD7_560	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
PKFBICOC_01749	1120746.CCNL01000011_gene1698	1.38e-119	351.0	COG1561@1|root,COG1561@2|Bacteria,2NPG5@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF1732)	yicC	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	DUF1732,YicC_N
PKFBICOC_01750	428125.CLOLEP_02910	6.07e-129	371.0	COG0217@1|root,COG0217@2|Bacteria,1TPP5@1239|Firmicutes,247NK@186801|Clostridia,3WHDN@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulatory protein	yebC	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
PKFBICOC_01752	1120746.CCNL01000011_gene1583	4.05e-281	790.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,2NNTP@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein S1	ispH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.4,2.7.4.25	ko:K00945,ko:K02945,ko:K03527	ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010	M00052,M00096,M00178	R00158,R00512,R01665,R05884,R08210	RC00002,RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	iECIAI1_1343.ECIAI1_0030,iECW_1372.ECW_m0028,iEKO11_1354.EKO11_3884,iEcHS_1320.EcHS_A0031,iEcolC_1368.EcolC_3626,iIT341.HP0400,iLJ478.TM1444,iPC815.YPO0477,iSFV_1184.SFV_0023,iSF_1195.SF0026,iSFxv_1172.SFxv_0027,iS_1188.S0028,iWFL_1372.ECW_m0028,iYL1228.KPN_00024	LYTB,S1
PKFBICOC_01753	883114.HMPREF9709_00773	1.4e-20	92.4	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,25B02@186801|Clostridia,22HER@1570339|Peptoniphilaceae	186801|Clostridia	I	Acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
PKFBICOC_01754	478749.BRYFOR_09888	5.39e-65	207.0	COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,24HEF@186801|Clostridia	186801|Clostridia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
PKFBICOC_01755	1120746.CCNL01000011_gene1579	3.11e-173	497.0	COG2081@1|root,COG2081@2|Bacteria,2NPCB@2323|unclassified Bacteria	2|Bacteria	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
PKFBICOC_01756	428125.CLOLEP_03186	3.16e-127	370.0	COG1737@1|root,COG1737@2|Bacteria,1TP7H@1239|Firmicutes,248ZD@186801|Clostridia,3WGRZ@541000|Ruminococcaceae	186801|Clostridia	K	transcriptional regulator RpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
PKFBICOC_01757	428125.CLOLEP_03235	1.17e-96	286.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,3WGIA@541000|Ruminococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
PKFBICOC_01758	1120746.CCNL01000011_gene1679	9.55e-129	372.0	COG0107@1|root,COG0107@2|Bacteria,2NNMK@2323|unclassified Bacteria	2|Bacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
PKFBICOC_01759	1693.BMIN_1092	7.95e-60	228.0	COG0366@1|root,COG5492@1|root,COG0366@2|Bacteria,COG5492@2|Bacteria,2GM4Q@201174|Actinobacteria,4CYYI@85004|Bifidobacteriales	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Big_2,CBM26,CBM_25,SLH
PKFBICOC_01762	511680.BUTYVIB_01595	2.25e-191	560.0	COG0366@1|root,COG0366@2|Bacteria,1TQSE@1239|Firmicutes,24C4V@186801|Clostridia,4BWVW@830|Butyrivibrio	186801|Clostridia	G	Starch-binding module 26	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Big_2,CBM26,CW_binding_1,Y_Y_Y
PKFBICOC_01763	1410624.JNKK01000002_gene895	2.4e-57	198.0	COG0463@1|root,COG0463@2|Bacteria,1TQ8C@1239|Firmicutes,248MK@186801|Clostridia,27KKC@186928|unclassified Lachnospiraceae	186801|Clostridia	M	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
PKFBICOC_01764	537013.CLOSTMETH_02817	2.22e-74	237.0	COG1284@1|root,COG1284@2|Bacteria,1TRAU@1239|Firmicutes,249DE@186801|Clostridia,3WSC6@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
PKFBICOC_01765	397290.C810_01780	1.84e-30	114.0	COG1939@1|root,COG1939@2|Bacteria,1VA5V@1239|Firmicutes,24MR1@186801|Clostridia,27NXY@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)	mrnC	-	-	ko:K11145	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Ribonuclease_3
PKFBICOC_01766	428125.CLOLEP_02657	1.79e-233	650.0	COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,3WH1H@541000|Ruminococcaceae	186801|Clostridia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
PKFBICOC_01767	1280689.AUJC01000001_gene2246	1.83e-51	163.0	COG0211@1|root,COG0211@2|Bacteria,1V6HW@1239|Firmicutes,24N3D@186801|Clostridia,36JKM@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
PKFBICOC_01768	428125.CLOLEP_02655	4.07e-27	102.0	COG2868@1|root,COG2868@2|Bacteria,1VKWQ@1239|Firmicutes,24TYG@186801|Clostridia,3WJZE@541000|Ruminococcaceae	186801|Clostridia	J	Cysteine protease Prp	-	-	-	ko:K07584	-	-	-	-	ko00000	-	-	-	Peptidase_Prp
PKFBICOC_01769	931276.Cspa_c51980	5.26e-31	112.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,24MRS@186801|Clostridia,36JGP@31979|Clostridiaceae	186801|Clostridia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
PKFBICOC_01770	428125.CLOLEP_02649	4.46e-145	415.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,248DB@186801|Clostridia,3WGHP@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
PKFBICOC_01771	1120746.CCNL01000011_gene1765	5.31e-170	490.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	ymfH	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
PKFBICOC_01772	394503.Ccel_0471	1.56e-66	225.0	COG0612@1|root,COG0612@2|Bacteria,1TPN6@1239|Firmicutes,248J8@186801|Clostridia,36G8B@31979|Clostridiaceae	186801|Clostridia	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16_C
PKFBICOC_01773	511680.BUTYVIB_00897	4.39e-117	359.0	COG3209@1|root,COG3291@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CBM_6,Flg_new,LRR_5,PKD,SLH
PKFBICOC_01776	1160721.RBI_I00554	1.82e-221	631.0	COG2197@1|root,COG2197@2|Bacteria,1U63E@1239|Firmicutes,24F84@186801|Clostridia,3WKYE@541000|Ruminococcaceae	186801|Clostridia	KT	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01777	1121334.KB911078_gene1195	2.57e-212	613.0	COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia,3WGCV@541000|Ruminococcaceae	186801|Clostridia	G	Alpha amylase, catalytic domain protein	apu	-	2.4.1.25,3.2.1.133,3.2.1.135,3.2.1.20,3.2.1.54	ko:K00705,ko:K01187,ko:K01208	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R02112,R03122,R05196,R06087,R06088,R11262	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH13,GH31,GH77	-	Alpha-amylase,Alpha-amylase_N,Glyco_hydro_77,Malt_amylase_C
PKFBICOC_01779	394503.Ccel_0176	5.23e-78	273.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,36DQX@31979|Clostridiaceae	186801|Clostridia	O	peptidase U32	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
PKFBICOC_01780	428125.CLOLEP_01236	2.65e-59	187.0	COG0756@1|root,COG0756@2|Bacteria,1V6HX@1239|Firmicutes,24K3X@186801|Clostridia,3WK0P@541000|Ruminococcaceae	186801|Clostridia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
PKFBICOC_01781	428125.CLOLEP_01234	1.77e-184	519.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,3WGF8@541000|Ruminococcaceae	186801|Clostridia	D	Cell shape determining protein, MreB Mrl family	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
PKFBICOC_01782	1507.HMPREF0262_01942	5.22e-29	117.0	COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia,36EKP@31979|Clostridiaceae	186801|Clostridia	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
PKFBICOC_01784	1105031.HMPREF1141_1472	6.7e-177	528.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia,36DW0@31979|Clostridiaceae	186801|Clostridia	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
PKFBICOC_01785	118173.KB235910_gene4709	5.74e-37	138.0	COG2894@1|root,COG2894@2|Bacteria,1G2A5@1117|Cyanobacteria,1H745@1150|Oscillatoriales	1117|Cyanobacteria	D	Belongs to the ParA family	minD	GO:0000910,GO:0007049,GO:0008150,GO:0009987,GO:0022402,GO:0032506,GO:0036214,GO:0051179,GO:0051301,GO:0061640	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA,ParA
PKFBICOC_01786	428125.CLOLEP_01229	4.36e-85	251.0	COG1803@1|root,COG1803@2|Bacteria,1V3KQ@1239|Firmicutes,24FUQ@186801|Clostridia,3WII3@541000|Ruminococcaceae	186801|Clostridia	G	methylglyoxal synthase	mgsA	-	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120	-	R01016	RC00424	ko00000,ko00001,ko01000	-	-	-	MGS
PKFBICOC_01787	1121334.KB911078_gene1208	1.87e-197	560.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,3WHGY@541000|Ruminococcaceae	186801|Clostridia	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
PKFBICOC_01788	1514668.JOOA01000002_gene3012	0.0	896.0	COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,247Z3@186801|Clostridia,3WGX1@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
PKFBICOC_01789	689781.AUJX01000037_gene2163	4.17e-31	122.0	2EN4B@1|root,33FSE@2|Bacteria,1VPF9@1239|Firmicutes,24SXK@186801|Clostridia,2PS4P@265975|Oribacterium	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Tim44,zinc_ribbon_2
PKFBICOC_01790	397290.C810_03926	1.95e-146	430.0	COG4260@1|root,COG4260@2|Bacteria,1TRYU@1239|Firmicutes,24901@186801|Clostridia,27ICK@186928|unclassified Lachnospiraceae	186801|Clostridia	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1
PKFBICOC_01791	180332.JTGN01000025_gene1558	7.33e-94	291.0	COG1594@1|root,COG1594@2|Bacteria,1UHVH@1239|Firmicutes,25E4D@186801|Clostridia	186801|Clostridia	K	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01793	411489.CLOL250_01571	1.57e-154	444.0	COG0502@1|root,COG0502@2|Bacteria,1TPYQ@1239|Firmicutes,248H8@186801|Clostridia,36DIQ@31979|Clostridiaceae	186801|Clostridia	C	radical SAM domain protein	hydE	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
PKFBICOC_01794	585394.RHOM_04680	5.3e-273	755.0	COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia	186801|Clostridia	C	biosynthesis protein ThiH	hydG	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
PKFBICOC_01795	877411.JMMA01000002_gene1715	3.77e-176	503.0	COG1160@1|root,COG1160@2|Bacteria,1UI84@1239|Firmicutes,25EDI@186801|Clostridia,3WSKW@541000|Ruminococcaceae	186801|Clostridia	S	Ferrous iron transport protein B	hydF	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
PKFBICOC_01796	537013.CLOSTMETH_02396	3.67e-222	632.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,25AZ5@186801|Clostridia,3WH41@541000|Ruminococcaceae	186801|Clostridia	I	AMP-dependent synthetase and ligase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C,Cupin_2,HTH_3
PKFBICOC_01797	585394.RHOM_02225	9.75e-124	367.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia	186801|Clostridia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
PKFBICOC_01798	1282887.AUJG01000005_gene174	8.32e-146	431.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
PKFBICOC_01799	411902.CLOBOL_04492	1.25e-214	609.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,21XU4@1506553|Lachnoclostridium	186801|Clostridia	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
PKFBICOC_01800	1304866.K413DRAFT_0116	4.94e-90	268.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia,36I54@31979|Clostridiaceae	186801|Clostridia	EH	Glutamine amidotransferase of anthranilate synthase	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
PKFBICOC_01801	556261.HMPREF0240_04079	4.91e-133	389.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,36ERC@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,Glycos_trans_3N,Glycos_transf_3
PKFBICOC_01802	1226325.HMPREF1548_04439	3.21e-105	312.0	COG0134@1|root,COG0134@2|Bacteria,1TR94@1239|Firmicutes,249ZY@186801|Clostridia,36EKM@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
PKFBICOC_01803	509191.AEDB02000098_gene3535	1.36e-241	669.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,3WGIV@541000|Ruminococcaceae	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
PKFBICOC_01804	871968.DESME_07805	7.75e-124	359.0	COG0159@1|root,COG0159@2|Bacteria,1TPXA@1239|Firmicutes,248M2@186801|Clostridia,261H4@186807|Peptococcaceae	186801|Clostridia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
PKFBICOC_01805	1160721.RBI_I01463	1.23e-129	372.0	COG0846@1|root,COG0846@2|Bacteria,1TQKD@1239|Firmicutes,2491J@186801|Clostridia,3WGSY@541000|Ruminococcaceae	186801|Clostridia	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
PKFBICOC_01806	1120746.CCNL01000017_gene3190	2.66e-26	99.4	COG0268@1|root,COG0268@2|Bacteria	2|Bacteria	J	rRNA binding	rpsT	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
PKFBICOC_01808	445973.CLOBAR_00924	6.68e-17	75.9	2E7YJ@1|root,33A8K@2|Bacteria,1VQP8@1239|Firmicutes,24QA7@186801|Clostridia,25U19@186804|Peptostreptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01809	632245.CLP_3839	3.08e-49	176.0	COG0727@1|root,COG0727@2|Bacteria,1TSB6@1239|Firmicutes,24AQ9@186801|Clostridia,36EKJ@31979|Clostridiaceae	186801|Clostridia	S	N-methylation of lysine residues in flagellin K00599	-	-	-	ko:K18475	-	-	-	-	ko00000,ko01000,ko02035	-	-	-	CxxCxxCC
PKFBICOC_01810	1291050.JAGE01000001_gene1916	7.1e-137	412.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,3WH1I@541000|Ruminococcaceae	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
PKFBICOC_01811	428125.CLOLEP_00265	4.07e-126	362.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,3WGIQ@541000|Ruminococcaceae	186801|Clostridia	K	response regulator receiver	-	-	-	ko:K07775	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
PKFBICOC_01812	428125.CLOLEP_00267	7.13e-144	412.0	COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,3WH30@541000|Ruminococcaceae	186801|Clostridia	C	Hydrolyase, tartrate alpha subunit fumarate domain protein, Fe-S type	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
PKFBICOC_01813	428125.CLOLEP_00268	1.87e-93	276.0	COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,24FRK@186801|Clostridia,3WI2S@541000|Ruminococcaceae	186801|Clostridia	C	Hydrolyase, tartrate beta subunit fumarate domain protein, Fe-S type	fumB	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
PKFBICOC_01815	1033837.WANG_0423	8.02e-56	183.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,4HBHA@91061|Bacilli,3F3JG@33958|Lactobacillaceae	91061|Bacilli	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
PKFBICOC_01816	1408436.JHXY01000049_gene257	1.99e-114	331.0	COG2184@1|root,COG2184@2|Bacteria,1TPUZ@1239|Firmicutes,248XF@186801|Clostridia,25W8Z@186806|Eubacteriaceae	186801|Clostridia	D	Fic/DOC family	fic	-	-	ko:K04095	-	-	-	-	ko00000,ko03036	-	-	-	Bro-N,Fic
PKFBICOC_01818	1321778.HMPREF1982_04002	1.52e-51	181.0	COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,267M7@186813|unclassified Clostridiales	186801|Clostridia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
PKFBICOC_01819	1120746.CCNL01000017_gene3180	9.3e-45	154.0	COG0576@1|root,COG0576@2|Bacteria,2NPSS@2323|unclassified Bacteria	2|Bacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
PKFBICOC_01820	1105031.HMPREF1141_3189	0.0	943.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,36DJ7@31979|Clostridiaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
PKFBICOC_01821	428125.CLOLEP_00077	1.01e-186	529.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,3WH82@541000|Ruminococcaceae	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
PKFBICOC_01822	1105031.HMPREF1141_2184	2.95e-136	396.0	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia,36FBU@31979|Clostridiaceae	186801|Clostridia	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
PKFBICOC_01824	1384066.JAGT01000001_gene872	1.11e-129	375.0	COG0489@1|root,COG0489@2|Bacteria,1TQ34@1239|Firmicutes,24817@186801|Clostridia,3WGBQ@541000|Ruminococcaceae	186801|Clostridia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	-	-	-	-	-	-	-	-	-	ParA
PKFBICOC_01827	1385514.N782_12495	3.12e-38	133.0	COG1476@1|root,COG1476@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,MazE_antitoxin
PKFBICOC_01828	1114972.AUAW01000001_gene1568	2.76e-05	48.5	COG1131@1|root,COG1131@2|Bacteria,1TPJE@1239|Firmicutes,4HB5U@91061|Bacilli,3F58G@33958|Lactobacillaceae	91061|Bacilli	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,HTH_3
PKFBICOC_01829	1262915.BN574_01425	2.98e-40	146.0	COG3503@1|root,COG3503@2|Bacteria,1V8H3@1239|Firmicutes	1239|Firmicutes	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
PKFBICOC_01831	428125.CLOLEP_03652	1.77e-167	474.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,3WG9U@541000|Ruminococcaceae	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
PKFBICOC_01832	428125.CLOLEP_03651	2.96e-167	483.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,3WGQA@541000|Ruminococcaceae	186801|Clostridia	E	acetylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iHN637.CLJU_RS10560	Aminotran_3
PKFBICOC_01833	742733.HMPREF9469_01580	3.87e-34	123.0	COG0454@1|root,COG0456@2|Bacteria,1V4GU@1239|Firmicutes,24IME@186801|Clostridia,2209N@1506553|Lachnoclostridium	186801|Clostridia	K	Psort location Cytoplasmic, score 8.87	RimI	-	2.3.1.1	ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
PKFBICOC_01834	742738.HMPREF9460_03351	2.64e-44	151.0	COG1943@1|root,COG1943@2|Bacteria,1VCIB@1239|Firmicutes,24MZS@186801|Clostridia,26BW3@186813|unclassified Clostridiales	186801|Clostridia	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
PKFBICOC_01835	428125.CLOLEP_03650	8.82e-150	427.0	COG0548@1|root,COG0548@2|Bacteria,1TP0N@1239|Firmicutes,2486J@186801|Clostridia,3WGF0@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10565	AA_kinase
PKFBICOC_01836	428125.CLOLEP_03649	6.07e-181	516.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,3WGSI@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
PKFBICOC_01837	1121334.KB911067_gene360	3.87e-181	511.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,3WGZJ@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
PKFBICOC_01838	1120746.CCNL01000017_gene3125	1.14e-230	646.0	COG0165@1|root,COG0165@2|Bacteria,2NP70@2323|unclassified Bacteria	2|Bacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,4.3.2.1	ko:K01755,ko:K14681	ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230	M00028,M00029,M00844,M00845	R00259,R01086	RC00004,RC00064,RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Acetyltransf_1,Lyase_1
PKFBICOC_01839	428125.CLOLEP_03644	2.34e-240	667.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,3WGG9@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
PKFBICOC_01840	585394.RHOM_04365	5.84e-73	219.0	COG1598@1|root,COG1598@2|Bacteria,1VAII@1239|Firmicutes,24I04@186801|Clostridia	186801|Clostridia	S	HicB family	-	-	-	ko:K18843	-	-	-	-	ko00000,ko02048	-	-	-	HicB,HicB_lk_antitox
PKFBICOC_01841	522772.Dacet_0298	2.16e-60	192.0	COG1853@1|root,COG1853@2|Bacteria,2GFRT@200930|Deferribacteres	200930|Deferribacteres	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
PKFBICOC_01842	1216932.CM240_0787	2.76e-174	566.0	COG0366@1|root,COG3934@1|root,COG4733@1|root,COG0366@2|Bacteria,COG3934@2|Bacteria,COG4733@2|Bacteria,1TP9E@1239|Firmicutes,248DX@186801|Clostridia,36DSD@31979|Clostridiaceae	186801|Clostridia	G	Alpha-amylase domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,CBM26
PKFBICOC_01843	246199.CUS_5839	1.5e-59	203.0	COG0642@1|root,COG2205@2|Bacteria,1TT7F@1239|Firmicutes,247UJ@186801|Clostridia,3WJ10@541000|Ruminococcaceae	186801|Clostridia	T	Histidine kinase- DNA gyrase B	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
PKFBICOC_01844	562743.JH976442_gene682	1.82e-61	199.0	COG0745@1|root,COG0745@2|Bacteria,1TT12@1239|Firmicutes,4HDD2@91061|Bacilli	91061|Bacilli	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
PKFBICOC_01845	1410633.JHWR01000009_gene1907	3.84e-105	353.0	COG0577@1|root,COG0577@2|Bacteria,1TRAS@1239|Firmicutes,248SQ@186801|Clostridia,27K7N@186928|unclassified Lachnospiraceae	186801|Clostridia	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
PKFBICOC_01846	203119.Cthe_0539	2.49e-106	312.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,3WH0X@541000|Ruminococcaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PKFBICOC_01847	1120746.CCNL01000017_gene3269	1.2e-102	309.0	COG0130@1|root,COG0130@2|Bacteria,2NP9J@2323|unclassified Bacteria	2|Bacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177,ko:K03483	-	-	-	-	ko00000,ko01000,ko03000,ko03016	-	-	iSB619.SA_RS06305	TruB-C_2,TruB_C_2,TruB_N
PKFBICOC_01848	428125.CLOLEP_01752	9.31e-98	298.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,3WGKS@541000|Ruminococcaceae	186801|Clostridia	S	domain protein	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
PKFBICOC_01849	428125.CLOLEP_01751	1.26e-53	171.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,3WJYA@541000|Ruminococcaceae	186801|Clostridia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
PKFBICOC_01850	428125.CLOLEP_01750	0.0	1014.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,3WHTD@541000|Ruminococcaceae	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
PKFBICOC_01851	1449063.JMLS01000018_gene5928	2.18e-13	68.2	COG1358@1|root,COG1358@2|Bacteria,1VEYG@1239|Firmicutes,4HNY7@91061|Bacilli,26Y6Y@186822|Paenibacillaceae	91061|Bacilli	J	ribosomal protein	ylxQ	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_L7Ae
PKFBICOC_01852	428125.CLOLEP_01748	4.72e-35	122.0	COG2740@1|root,COG2740@2|Bacteria	2|Bacteria	K	Nucleic-acid-binding protein implicated in transcription termination	ylxR	-	-	ko:K02600,ko:K07742	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	DUF448
PKFBICOC_01853	1105031.HMPREF1141_1871	3.93e-153	443.0	COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia,36DXE@31979|Clostridiaceae	186801|Clostridia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
PKFBICOC_01854	428125.CLOLEP_01746	1.5e-62	198.0	COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,24N1G@186801|Clostridia,3WJSY@541000|Ruminococcaceae	186801|Clostridia	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
PKFBICOC_01856	428125.CLOLEP_01608	1.35e-75	236.0	28P0Q@1|root,2ZBX8@2|Bacteria,1V22P@1239|Firmicutes,248XV@186801|Clostridia,3WJK7@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01857	1121334.KB911071_gene2146	1.88e-98	296.0	COG0122@1|root,COG0122@2|Bacteria,1TQAF@1239|Firmicutes,2495X@186801|Clostridia,3WGHY@541000|Ruminococcaceae	186801|Clostridia	L	8-oxoguanine DNA glycosylase	alkA	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
PKFBICOC_01858	1345697.M493_16510	1.6e-10	71.2	COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,1TT2K@1239|Firmicutes,4ISYS@91061|Bacilli,1WF59@129337|Geobacillus	91061|Bacilli	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,PG_binding_1
PKFBICOC_01859	428125.CLOLEP_02036	7.35e-151	442.0	COG2607@1|root,COG2607@2|Bacteria,1TQDJ@1239|Firmicutes,2483S@186801|Clostridia,3WH9K@541000|Ruminococcaceae	186801|Clostridia	S	ATPase (AAA superfamily)	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
PKFBICOC_01860	1203606.HMPREF1526_00041	3.72e-109	330.0	COG1086@1|root,COG1086@2|Bacteria,1U3RH@1239|Firmicutes,24K9I@186801|Clostridia,36KEF@31979|Clostridiaceae	186801|Clostridia	GM	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
PKFBICOC_01861	428125.CLOLEP_01183	8.06e-79	243.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,3WISD@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
PKFBICOC_01863	428125.CLOLEP_01611	5.61e-103	306.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia,3WGPU@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
PKFBICOC_01865	471856.Jden_2236	4.64e-05	52.0	COG0494@1|root,COG2062@1|root,COG0494@2|Bacteria,COG2062@2|Bacteria,2GNRV@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the NUDIX hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
PKFBICOC_01866	428125.CLOLEP_02548	1.8e-53	190.0	28IAA@1|root,2Z8CW@2|Bacteria,1TQHP@1239|Firmicutes,24GSB@186801|Clostridia,3WHJM@541000|Ruminococcaceae	186801|Clostridia	S	DHHW protein	-	-	-	-	-	-	-	-	-	-	-	-	DHHW
PKFBICOC_01867	428125.CLOLEP_00283	5.8e-205	579.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,3WGG5@541000|Ruminococcaceae	186801|Clostridia	EK	Aminotransferase, class I	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
PKFBICOC_01868	428125.CLOLEP_00284	8.28e-183	515.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia,3WGS4@541000|Ruminococcaceae	186801|Clostridia	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
PKFBICOC_01869	1121296.JONJ01000005_gene1237	1.1e-46	179.0	COG4346@1|root,COG5542@1|root,COG4346@2|Bacteria,COG5542@2|Bacteria,1TSHX@1239|Firmicutes,24AN2@186801|Clostridia	186801|Clostridia	M	PFAM glycosyl transferase family 39	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	GT87,PMT,PMT_2,PMT_4TMC
PKFBICOC_01870	1123313.ATUT01000016_gene634	1.49e-175	506.0	COG0534@1|root,COG0534@2|Bacteria,1TP5P@1239|Firmicutes	1239|Firmicutes	V	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	MatE
PKFBICOC_01871	411460.RUMTOR_01409	3.43e-66	234.0	COG4805@1|root,COG4805@2|Bacteria,1TREN@1239|Firmicutes,249U9@186801|Clostridia,3XYKE@572511|Blautia	186801|Clostridia	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
PKFBICOC_01872	1052684.PPM_4821	2.15e-17	87.0	COG4760@1|root,COG4760@2|Bacteria,1TQ9Z@1239|Firmicutes,4HEPV@91061|Bacilli,26SQG@186822|Paenibacillaceae	91061|Bacilli	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	BaxI_1
PKFBICOC_01873	1280689.AUJC01000001_gene2401	9.85e-48	163.0	COG0637@1|root,COG0637@2|Bacteria,1VA5Z@1239|Firmicutes,24JNY@186801|Clostridia,36JHH@31979|Clostridiaceae	186801|Clostridia	G	IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
PKFBICOC_01874	1391646.AVSU01000026_gene2342	2.6e-114	350.0	COG0534@1|root,COG0534@2|Bacteria,1TPPJ@1239|Firmicutes,25AZE@186801|Clostridia,25SUZ@186804|Peptostreptococcaceae	186801|Clostridia	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
PKFBICOC_01875	1121334.KB911067_gene247	3.29e-160	462.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia,3WGQB@541000|Ruminococcaceae	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase	pdxB	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
PKFBICOC_01876	428125.CLOLEP_03881	7.95e-210	585.0	COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,247SM@186801|Clostridia,3WGD1@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
PKFBICOC_01877	1160721.RBI_I00681	2.45e-158	451.0	COG0284@1|root,COG0284@2|Bacteria,1TQ7P@1239|Firmicutes,247SZ@186801|Clostridia,3WH6X@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17585	OMPdecase
PKFBICOC_01878	1336241.JAEB01000005_gene1441	3.38e-157	449.0	COG0119@1|root,COG0119@2|Bacteria,1TS0A@1239|Firmicutes,247MU@186801|Clostridia,25V7F@186806|Eubacteriaceae	186801|Clostridia	E	HMGL-like	-	-	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
PKFBICOC_01879	1120746.CCNL01000017_gene2970	8.43e-192	545.0	COG0044@1|root,COG0044@2|Bacteria,2NNWP@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
PKFBICOC_01881	411473.RUMCAL_01644	6.85e-299	832.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,3WGUC@541000|Ruminococcaceae	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
PKFBICOC_01882	1410670.JHXF01000001_gene2655	3.52e-247	703.0	COG1086@1|root,COG1086@2|Bacteria,1TR3W@1239|Firmicutes,247PW@186801|Clostridia,3WGZ4@541000|Ruminococcaceae	186801|Clostridia	GM	Polysaccharide biosynthesis protein	capD	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
PKFBICOC_01883	742733.HMPREF9469_01977	3.1e-44	165.0	COG1215@1|root,COG1408@1|root,COG1215@2|Bacteria,COG1408@2|Bacteria,1UU17@1239|Firmicutes,248PS@186801|Clostridia,21XRU@1506553|Lachnoclostridium	186801|Clostridia	M	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
PKFBICOC_01884	1408823.AXUS01000007_gene2970	1.17e-10	70.1	COG2207@1|root,COG3664@1|root,COG2207@2|Bacteria,COG3664@2|Bacteria,1TQGI@1239|Firmicutes,2490Q@186801|Clostridia	186801|Clostridia	G	PFAM glycoside hydrolase family 39	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	AraC_binding,Cupin_2,Glyco_hydro_39,HTH_18
PKFBICOC_01885	1514668.JOOA01000002_gene2327	1.01e-60	198.0	COG0062@1|root,COG0062@2|Bacteria,1VE29@1239|Firmicutes,24JS0@186801|Clostridia,3WJPQ@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX	nnrE	-	5.1.99.6	ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	YjeF_N
PKFBICOC_01886	1410617.JHXH01000001_gene806	1.31e-45	159.0	28RJ8@1|root,2ZDY4@2|Bacteria,1V64R@1239|Firmicutes,25GI1@186801|Clostridia,3WSFI@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01887	1469948.JPNB01000001_gene447	3.22e-87	276.0	2F3Y4@1|root,33WQ6@2|Bacteria,1UKAG@1239|Firmicutes,24JVD@186801|Clostridia	186801|Clostridia	M	Psort location CytoplasmicMembrane, score 9.99	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
PKFBICOC_01889	1226325.HMPREF1548_01693	1.21e-21	89.4	2C5R4@1|root,33UE0@2|Bacteria,1VUS0@1239|Firmicutes,25QAI@186801|Clostridia,36SYX@31979|Clostridiaceae	186801|Clostridia	S	Transposon-encoded protein TnpV	-	-	-	-	-	-	-	-	-	-	-	-	TnpV
PKFBICOC_01894	448385.sce3123	4.02e-05	57.0	COG0457@1|root,COG0515@1|root,COG3899@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3899@2|Bacteria,1QA6R@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
PKFBICOC_01895	997884.HMPREF1068_01785	1.38e-63	215.0	COG0641@1|root,COG0641@2|Bacteria,4NVVA@976|Bacteroidetes,2FRE1@200643|Bacteroidia,4ANKC@815|Bacteroidaceae	976|Bacteroidetes	C	radical SAM domain protein	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
PKFBICOC_01899	448385.sce3123	3.8e-05	57.0	COG0457@1|root,COG0515@1|root,COG3899@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3899@2|Bacteria,1QA6R@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
PKFBICOC_01903	428125.CLOLEP_03808	5.36e-60	206.0	2DM9Q@1|root,329N9@2|Bacteria,1VQK9@1239|Firmicutes,24UVD@186801|Clostridia,3WRZH@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01904	1034345.CAEM01000014_gene260	2e-210	590.0	COG1373@1|root,COG1373@2|Bacteria,2IBJT@201174|Actinobacteria,4CVRT@84998|Coriobacteriia	84998|Coriobacteriia	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
PKFBICOC_01905	411459.RUMOBE_00372	1.71e-93	289.0	2DB8G@1|root,2Z7RT@2|Bacteria,1US26@1239|Firmicutes,24B9G@186801|Clostridia,3Y166@572511|Blautia	186801|Clostridia	-	-	-	-	-	ko:K18640	-	-	-	-	ko00000,ko04812	-	-	-	StbA
PKFBICOC_01907	1507.HMPREF0262_00053	1.26e-34	122.0	2CDK1@1|root,32G0D@2|Bacteria,1V6YH@1239|Firmicutes,24K20@186801|Clostridia,36T6Q@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MobC,RHH_1
PKFBICOC_01908	742735.HMPREF9467_03136	8.42e-148	436.0	COG3843@1|root,COG3843@2|Bacteria,1TPRX@1239|Firmicutes,248VT@186801|Clostridia,222MK@1506553|Lachnoclostridium	186801|Clostridia	U	Relaxase/Mobilisation nuclease domain	-	-	-	-	-	-	-	-	-	-	-	-	Relaxase
PKFBICOC_01909	1203606.HMPREF1526_01072	2.74e-14	79.0	COG3935@1|root,COG3935@2|Bacteria,1TPPF@1239|Firmicutes,249NG@186801|Clostridia,36HWH@31979|Clostridiaceae	186801|Clostridia	L	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	HTH_36,RepA_N
PKFBICOC_01911	665956.HMPREF1032_03348	3.24e-19	97.1	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,24B23@186801|Clostridia,3WID1@541000|Ruminococcaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
PKFBICOC_01915	1507.HMPREF0262_01199	1.52e-34	137.0	COG3583@1|root,COG3584@1|root,COG3583@2|Bacteria,COG3584@2|Bacteria,1TTIK@1239|Firmicutes,24997@186801|Clostridia,36DTZ@31979|Clostridiaceae	186801|Clostridia	S	G5 domain protein	yabE	-	-	-	-	-	-	-	-	-	-	-	3D,DUF348,G5
PKFBICOC_01916	1123311.KB904449_gene273	1.44e-25	109.0	COG2207@1|root,COG2207@2|Bacteria,1UZ0Q@1239|Firmicutes,4IPX1@91061|Bacilli	91061|Bacilli	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
PKFBICOC_01917	1410658.JHWI01000013_gene803	5.06e-19	91.7	COG2207@1|root,COG2207@2|Bacteria,1V27P@1239|Firmicutes,3VUDX@526524|Erysipelotrichia	526524|Erysipelotrichia	K	COG COG2207 AraC-type DNA-binding domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
PKFBICOC_01918	1403819.BATR01000092_gene2664	1.78e-49	175.0	COG0657@1|root,COG0657@2|Bacteria,46TVH@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,EF-hand_5
PKFBICOC_01919	877415.JNJQ01000067_gene1796	9.02e-20	98.2	COG5492@1|root,COG5492@2|Bacteria,1TS8J@1239|Firmicutes,3VRCS@526524|Erysipelotrichia	526524|Erysipelotrichia	N	Leucine rich repeats (6 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,FIVAR,LRR_5,SdrD_B
PKFBICOC_01920	1449338.JQLU01000005_gene1801	2.47e-17	85.1	COG0664@1|root,COG0664@2|Bacteria,1VD7I@1239|Firmicutes,4HMTP@91061|Bacilli	91061|Bacilli	K	cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
PKFBICOC_01921	428125.CLOLEP_00224	2.71e-249	691.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,3WG9G@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35,4.2.1.85	ko:K01703,ko:K20452	ko00290,ko00660,ko00760,ko00966,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map00966,map01100,map01110,map01120,map01210,map01230	M00432,M00535	R03069,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00843,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04465	Aconitase
PKFBICOC_01922	428125.CLOLEP_00223	5.46e-90	266.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,3WIGV@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35,4.2.1.85	ko:K01704,ko:K20453	ko00290,ko00660,ko00760,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map01100,map01110,map01120,map01210,map01230	M00432,M00535	R03069,R03896,R03898,R03968,R04001,R10170	RC00843,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
PKFBICOC_01923	476272.RUMHYD_00816	1.63e-19	102.0	COG1196@1|root,COG5492@1|root,COG1196@2|Bacteria,COG5492@2|Bacteria,1U4RJ@1239|Firmicutes,25K63@186801|Clostridia,3Y24N@572511|Blautia	186801|Clostridia	N	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
PKFBICOC_01924	1499683.CCFF01000016_gene781	0.0	934.0	COG0058@1|root,COG0058@2|Bacteria,1TQAJ@1239|Firmicutes,248E1@186801|Clostridia,36E5W@31979|Clostridiaceae	186801|Clostridia	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
PKFBICOC_01925	1391647.AVSV01000018_gene766	5.8e-216	612.0	COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,36DWR@31979|Clostridiaceae	186801|Clostridia	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
PKFBICOC_01926	665956.HMPREF1032_00709	6.15e-43	155.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,3WGRD@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
PKFBICOC_01927	663278.Ethha_2612	9.52e-63	203.0	COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia,3WIFN@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
PKFBICOC_01928	1134413.ANNK01000048_gene1009	6.27e-33	126.0	COG0775@1|root,COG0775@2|Bacteria,1U7WK@1239|Firmicutes,4HB8K@91061|Bacilli,1ZB7T@1386|Bacillus	91061|Bacilli	E	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
PKFBICOC_01929	428125.CLOLEP_00230	1.03e-248	701.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,3WHFZ@541000|Ruminococcaceae	186801|Clostridia	H	acetolactate synthase large subunit	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
PKFBICOC_01930	411463.EUBVEN_01765	2.96e-176	510.0	COG2233@1|root,COG2233@2|Bacteria,1TQKX@1239|Firmicutes,2485Z@186801|Clostridia,25VSJ@186806|Eubacteriaceae	186801|Clostridia	F	Psort location CytoplasmicMembrane, score 10.00	uraA	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
PKFBICOC_01931	411469.EUBHAL_03061	8.46e-116	336.0	COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,248FV@186801|Clostridia,25V9I@186806|Eubacteriaceae	186801|Clostridia	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
PKFBICOC_01932	1449050.JNLE01000003_gene2058	5.8e-36	134.0	COG3279@1|root,COG3279@2|Bacteria,1UYV2@1239|Firmicutes,24J31@186801|Clostridia,36VM5@31979|Clostridiaceae	186801|Clostridia	KT	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
PKFBICOC_01934	428125.CLOLEP_02436	4.14e-92	298.0	COG3225@1|root,COG3225@2|Bacteria,1V597@1239|Firmicutes,25DA0@186801|Clostridia,3WSG9@541000|Ruminococcaceae	186801|Clostridia	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
PKFBICOC_01935	411471.SUBVAR_05541	9.65e-26	108.0	COG1277@1|root,COG1277@2|Bacteria,1UZXS@1239|Firmicutes,248ME@186801|Clostridia,3WI9V@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_2,ABC2_membrane_3
PKFBICOC_01936	428125.CLOLEP_02434	1.01e-128	378.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,3WH5S@541000|Ruminococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
PKFBICOC_01937	1507.HMPREF0262_02715	2.68e-47	154.0	2ANER@1|root,315MJ@2|Bacteria,1V6SU@1239|Firmicutes,24JBZ@186801|Clostridia,36JME@31979|Clostridiaceae	186801|Clostridia	S	stage V sporulation protein	spoVAE	-	-	ko:K06407	-	-	-	-	ko00000	-	-	-	SpoVAC_SpoVAEB
PKFBICOC_01939	1341157.RF007C_14565	6.78e-168	521.0	COG4485@1|root,COG4485@2|Bacteria,1TRR1@1239|Firmicutes,24BHM@186801|Clostridia,3WHJ5@541000|Ruminococcaceae	186801|Clostridia	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	GtrA,YfhO
PKFBICOC_01940	511680.BUTYVIB_01614	3.9e-132	385.0	COG0463@1|root,COG0463@2|Bacteria,1TPR3@1239|Firmicutes,248Q5@186801|Clostridia,4BXYN@830|Butyrivibrio	186801|Clostridia	M	Glycosyltransferase like family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
PKFBICOC_01941	1235835.C814_01664	2.35e-42	144.0	COG2246@1|root,COG2246@2|Bacteria,1V7CF@1239|Firmicutes,24KKV@186801|Clostridia,3WKZZ@541000|Ruminococcaceae	186801|Clostridia	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
PKFBICOC_01942	428125.CLOLEP_00277	6.25e-83	246.0	COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,24H94@186801|Clostridia,3WIS1@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
PKFBICOC_01943	537013.CLOSTMETH_01390	2.41e-63	197.0	COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia,3WIWI@541000|Ruminococcaceae	186801|Clostridia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
PKFBICOC_01944	1121334.KB911066_gene970	4.33e-30	113.0	COG0642@1|root,COG2205@2|Bacteria,1VNVZ@1239|Firmicutes,24VI6@186801|Clostridia	186801|Clostridia	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Usp
PKFBICOC_01948	1410670.JHXF01000004_gene1724	9.42e-133	387.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,3WHCD@541000|Ruminococcaceae	186801|Clostridia	GK	ROK family	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
PKFBICOC_01949	428125.CLOLEP_01281	2.4e-284	785.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,3WGWJ@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
PKFBICOC_01951	585394.RHOM_02160	1.88e-28	107.0	2DNQ7@1|root,32YJ2@2|Bacteria,1VFJY@1239|Firmicutes,24S09@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
PKFBICOC_01952	411467.BACCAP_00164	5.76e-25	98.2	COG4640@1|root,COG4640@2|Bacteria,1VB94@1239|Firmicutes,24N0R@186801|Clostridia,269MN@186813|unclassified Clostridiales	186801|Clostridia	S	Domain of unknown function (DUF4234)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4234,zinc_ribbon_2
PKFBICOC_01953	411469.EUBHAL_00349	4.8e-265	731.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,25VBF@186806|Eubacteriaceae	186801|Clostridia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
PKFBICOC_01954	1121334.KB911079_gene449	4.83e-107	319.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,3WHV1@541000|Ruminococcaceae	186801|Clostridia	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
PKFBICOC_01955	1121334.KB911079_gene450	1.29e-124	361.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,3WGTZ@541000|Ruminococcaceae	186801|Clostridia	D	CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
PKFBICOC_01956	428125.CLOLEP_01273	1.62e-95	289.0	COG1475@1|root,COG1475@2|Bacteria,1TP0I@1239|Firmicutes,2488X@186801|Clostridia,3WINS@541000|Ruminococcaceae	186801|Clostridia	K	Belongs to the ParB family	noc	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
PKFBICOC_01957	484770.UFO1_4489	2.52e-86	263.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,4H2EW@909932|Negativicutes	909932|Negativicutes	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
PKFBICOC_01958	428125.CLOLEP_01270	0.0	954.0	COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,3WGGQ@541000|Ruminococcaceae	186801|Clostridia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
PKFBICOC_01959	428125.CLOLEP_01269	6.35e-195	556.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia,3WGHG@541000|Ruminococcaceae	186801|Clostridia	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
PKFBICOC_01960	428125.CLOLEP_01268	4.87e-90	276.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,3WHR4@541000|Ruminococcaceae	186801|Clostridia	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
PKFBICOC_01961	622312.ROSEINA2194_02514	6.71e-15	84.0	COG0706@1|root,COG1887@1|root,COG0706@2|Bacteria,COG1887@2|Bacteria,1V0BX@1239|Firmicutes,24DWH@186801|Clostridia	186801|Clostridia	M	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase	-	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,Glyphos_transf
PKFBICOC_01962	996637.SGM_3529	9.69e-26	98.6	COG0759@1|root,COG0759@2|Bacteria,2GQZG@201174|Actinobacteria	201174|Actinobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
PKFBICOC_01963	485916.Dtox_4369	1.57e-11	63.5	COG0594@1|root,COG0594@2|Bacteria,1VA78@1239|Firmicutes,24QK5@186801|Clostridia,262VE@186807|Peptococcaceae	186801|Clostridia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
PKFBICOC_01964	1105031.HMPREF1141_2304	9.02e-18	74.7	COG0230@1|root,COG0230@2|Bacteria,1VK90@1239|Firmicutes,24UGN@186801|Clostridia,36P8G@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
PKFBICOC_01965	428125.CLOLEP_01262	4.13e-199	566.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,3WGJH@541000|Ruminococcaceae	186801|Clostridia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
PKFBICOC_01966	428125.CLOLEP_01258	7.17e-141	414.0	COG0592@1|root,COG0592@2|Bacteria,1TQ7J@1239|Firmicutes,248EG@186801|Clostridia,3WGZ2@541000|Ruminococcaceae	186801|Clostridia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
PKFBICOC_01967	1519439.JPJG01000095_gene930	6.04e-25	94.7	COG2501@1|root,COG2501@2|Bacteria,1TU9W@1239|Firmicutes,25NDU@186801|Clostridia,2N7QR@216572|Oscillospiraceae	186801|Clostridia	S	S4 domain	-	-	-	ko:K14761	-	-	-	-	ko00000,ko03009	-	-	-	S4_2
PKFBICOC_01968	1235797.C816_01896	1.8e-85	270.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia,2N6MG@216572|Oscillospiraceae	186801|Clostridia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
PKFBICOC_01969	428125.CLOLEP_01255	4.52e-31	112.0	2E36Q@1|root,32Y6E@2|Bacteria,1VEZV@1239|Firmicutes,24MQP@186801|Clostridia,3WKJK@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF370)	-	-	-	-	-	-	-	-	-	-	-	-	DUF370
PKFBICOC_01971	428125.CLOLEP_01253	0.0	998.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,3WGZ0@541000|Ruminococcaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
PKFBICOC_01972	632335.Calkr_1248	2.1e-31	116.0	COG0824@1|root,COG0824@2|Bacteria,1VAGM@1239|Firmicutes,24NBX@186801|Clostridia	186801|Clostridia	S	acyl-CoA thioester hydrolase, YbgC YbaW family	FcbC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
PKFBICOC_01973	428125.CLOLEP_01250	0.0	1075.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,3WGW0@541000|Ruminococcaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
PKFBICOC_01975	428125.CLOLEP_01486	8.82e-56	183.0	COG0283@1|root,COG0283@2|Bacteria,1VB1M@1239|Firmicutes,24YPD@186801|Clostridia,3WSQB@541000|Ruminococcaceae	186801|Clostridia	F	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
PKFBICOC_01977	445972.ANACOL_03704	6.89e-38	132.0	COG0433@1|root,COG0433@2|Bacteria,1VF8X@1239|Firmicutes,24N9T@186801|Clostridia,3WJSW@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01978	428125.CLOLEP_00566	9.51e-256	709.0	COG0166@1|root,COG0166@2|Bacteria,1TP29@1239|Firmicutes,2487A@186801|Clostridia,3WHJX@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
PKFBICOC_01979	428125.CLOLEP_00565	2.68e-150	436.0	COG1686@1|root,COG1686@2|Bacteria,1TQN0@1239|Firmicutes,249B3@186801|Clostridia,3WHE1@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the peptidase S11 family	dacF	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
PKFBICOC_01980	1410630.JNKP01000001_gene1953	3.07e-74	226.0	COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,27M94@186928|unclassified Lachnospiraceae	186801|Clostridia	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
PKFBICOC_01981	865861.AZSU01000010_gene729	1.29e-56	187.0	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,36EIP@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS20335	IspD
PKFBICOC_01982	518637.EUBIFOR_00899	1.19e-245	681.0	COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,3VPVX@526524|Erysipelotrichia	526524|Erysipelotrichia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Cys_Met_Meta_PP
PKFBICOC_01984	411473.RUMCAL_00130	6.48e-11	73.2	COG3291@1|root,COG3291@2|Bacteria,1UK83@1239|Firmicutes,25FQ5@186801|Clostridia	186801|Clostridia	S	Leucine rich repeats (6 copies)	-	-	-	-	-	-	-	-	-	-	-	-	LRR_5
PKFBICOC_01985	768710.DesyoDRAFT_1911	3.45e-24	92.8	COG1476@1|root,COG1476@2|Bacteria,1VEIS@1239|Firmicutes,24R6J@186801|Clostridia,265K6@186807|Peptococcaceae	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
PKFBICOC_01987	1105031.HMPREF1141_0806	2.94e-79	241.0	COG0452@1|root,COG0452@2|Bacteria,1TQPT@1239|Firmicutes,24HE6@186801|Clostridia,36I49@31979|Clostridiaceae	186801|Clostridia	H	Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)	spoVFB	-	-	ko:K06411	-	-	-	-	ko00000	-	-	-	Flavoprotein
PKFBICOC_01988	877414.ATWA01000002_gene1127	1.48e-53	183.0	COG0111@1|root,COG0111@2|Bacteria,1TPUC@1239|Firmicutes,253BG@186801|Clostridia,26810@186813|unclassified Clostridiales	186801|Clostridia	EH	Dipicolinate synthase subunit A N-terminal domain	spoVFA	-	-	ko:K06410	-	-	-	-	ko00000	-	-	-	2-Hacid_dh_C,AlaDh_PNT_C,DpaA_N
PKFBICOC_01990	483218.BACPEC_02714	4.17e-169	474.0	COG1028@1|root,COG1028@2|Bacteria,1TRYD@1239|Firmicutes,248RG@186801|Clostridia,267M6@186813|unclassified Clostridiales	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
PKFBICOC_01995	500632.CLONEX_00758	1.89e-16	72.4	2DPYU@1|root,33404@2|Bacteria,1VEMP@1239|Firmicutes,24UUX@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_01996	469596.HMPREF9488_02215	3.82e-132	382.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,3VPAB@526524|Erysipelotrichia	526524|Erysipelotrichia	D	CobQ CobB MinD ParA nucleotide binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
PKFBICOC_01997	1321372.AQQB01000003_gene1485	5.27e-163	463.0	COG1475@1|root,COG1475@2|Bacteria,1TR7C@1239|Firmicutes,4IJ2M@91061|Bacilli,1WTIK@1307|Streptococcus suis	91061|Bacilli	K	ParB-like nuclease domain	parB_1	-	-	-	-	-	-	-	-	-	-	-	ParBc
PKFBICOC_01999	394503.Ccel_2751	4.77e-282	790.0	COG1403@1|root,COG3344@1|root,COG1403@2|Bacteria,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,248M4@186801|Clostridia,36F7Z@31979|Clostridiaceae	186801|Clostridia	L	Reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
PKFBICOC_02000	457412.RSAG_00331	1.13e-166	513.0	COG4932@1|root,COG4932@2|Bacteria,1TRG6@1239|Firmicutes,2492K@186801|Clostridia,3WHHA@541000|Ruminococcaceae	186801|Clostridia	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
PKFBICOC_02001	938289.CAJN020000007_gene263	1.19e-42	143.0	COG2156@1|root,COG2156@2|Bacteria,1V4GE@1239|Firmicutes,24G0R@186801|Clostridia	186801|Clostridia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
PKFBICOC_02002	478749.BRYFOR_06073	2.6e-61	196.0	COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia	186801|Clostridia	P	domain protein	ktrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
PKFBICOC_02004	511680.BUTYVIB_02236	1.36e-129	377.0	COG0598@1|root,COG0598@2|Bacteria,1TPSV@1239|Firmicutes,24DE3@186801|Clostridia,4BXPM@830|Butyrivibrio	186801|Clostridia	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
PKFBICOC_02005	1123075.AUDP01000005_gene940	3.7e-84	273.0	COG0642@1|root,COG2205@2|Bacteria,1TQHB@1239|Firmicutes,247S4@186801|Clostridia,3WG8P@541000|Ruminococcaceae	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD
PKFBICOC_02006	411462.DORLON_01369	2.65e-54	189.0	COG0642@1|root,COG2205@2|Bacteria,1TQHB@1239|Firmicutes,247S4@186801|Clostridia,27WKD@189330|Dorea	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD
PKFBICOC_02007	411463.EUBVEN_00903	1.53e-64	219.0	COG0642@1|root,COG2205@2|Bacteria,1TQHB@1239|Firmicutes,247S4@186801|Clostridia,25UXP@186806|Eubacteriaceae	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD
PKFBICOC_02008	883113.HMPREF9708_01016	4.51e-54	175.0	COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,4HA8Q@91061|Bacilli,27DDF@186827|Aerococcaceae	91061|Bacilli	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667,ko:K07668	ko02020,ko02024,map02020,map02024	M00454,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
PKFBICOC_02009	511680.BUTYVIB_02251	2.35e-56	178.0	2C5R4@1|root,2ZC1N@2|Bacteria,1V292@1239|Firmicutes,25CQM@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	TnpV
PKFBICOC_02010	742735.HMPREF9467_03153	9.83e-13	63.2	2DIMN@1|root,303NN@2|Bacteria,1TUX8@1239|Firmicutes,25I11@186801|Clostridia,223GZ@1506553|Lachnoclostridium	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_02011	999411.HMPREF1092_03001	7.14e-103	314.0	28Q4T@1|root,2ZCMX@2|Bacteria,1VSDM@1239|Firmicutes,24HWR@186801|Clostridia,36RTM@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_02013	398512.JQKC01000001_gene2271	3.79e-39	139.0	COG2856@1|root,COG2856@2|Bacteria,1V1KH@1239|Firmicutes,24GHH@186801|Clostridia,3WKN6@541000|Ruminococcaceae	186801|Clostridia	E	IrrE N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M78
PKFBICOC_02014	871963.Desdi_1391	1.2e-48	159.0	COG1476@1|root,COG1476@2|Bacteria,1VAJB@1239|Firmicutes,24N2Z@186801|Clostridia	186801|Clostridia	K	DNA-binding helix-turn-helix protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19
PKFBICOC_02015	742735.HMPREF9467_03117	3.88e-219	613.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,21XPT@1506553|Lachnoclostridium	186801|Clostridia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
PKFBICOC_02017	742735.HMPREF9467_03115	3.78e-34	118.0	2E5HW@1|root,33098@2|Bacteria,1VFFD@1239|Firmicutes,24QMD@186801|Clostridia,223J3@1506553|Lachnoclostridium	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_02018	742735.HMPREF9467_03114	4.82e-71	224.0	COG2856@1|root,COG2856@2|Bacteria,1UY38@1239|Firmicutes,24DU5@186801|Clostridia,21Z40@1506553|Lachnoclostridium	186801|Clostridia	E	IrrE N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M78
PKFBICOC_02021	1321372.AQQB01000051_gene1445	1.16e-62	199.0	COG2337@1|root,COG2337@2|Bacteria,1V6DK@1239|Firmicutes,4HGXF@91061|Bacilli	91061|Bacilli	L	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
PKFBICOC_02022	478749.BRYFOR_09165	1.84e-23	92.0	COG3311@1|root,COG3311@2|Bacteria,1V8AE@1239|Firmicutes,24KDT@186801|Clostridia	186801|Clostridia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
PKFBICOC_02023	397290.C810_04784	9.48e-48	157.0	29YMG@1|root,30KGY@2|Bacteria,1V4T3@1239|Firmicutes,24I7T@186801|Clostridia,27N4H@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
PKFBICOC_02024	999413.HMPREF1094_02160	4.15e-190	543.0	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,3VQ03@526524|Erysipelotrichia	526524|Erysipelotrichia	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
PKFBICOC_02025	1280698.AUJS01000042_gene3267	4.97e-97	282.0	COG1846@1|root,COG1846@2|Bacteria,1V8KT@1239|Firmicutes,24B99@186801|Clostridia	186801|Clostridia	K	Transcriptional regulator, MarR family	mgrA	-	-	-	-	-	-	-	-	-	-	-	MarR
PKFBICOC_02026	748224.HMPREF9436_03129	1.52e-173	483.0	COG4422@1|root,COG4422@2|Bacteria,1TPRY@1239|Firmicutes,247VT@186801|Clostridia,3WI0I@541000|Ruminococcaceae	186801|Clostridia	F	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF5131
PKFBICOC_02027	622312.ROSEINA2194_01462	1.18e-227	625.0	COG1533@1|root,COG1533@2|Bacteria,1TRIS@1239|Firmicutes,25CEW@186801|Clostridia	186801|Clostridia	L	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
PKFBICOC_02028	411474.COPEUT_00066	8.35e-164	458.0	COG0745@1|root,COG0745@2|Bacteria,1UDAQ@1239|Firmicutes,249RQ@186801|Clostridia	186801|Clostridia	KT	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
PKFBICOC_02029	411474.COPEUT_00067	0.0	1242.0	COG0642@1|root,COG2205@2|Bacteria,1TQHB@1239|Firmicutes,247S4@186801|Clostridia	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD
PKFBICOC_02030	411474.COPEUT_00068	1.47e-45	147.0	2FJ5Y@1|root,34AW2@2|Bacteria,1W1C4@1239|Firmicutes,253GU@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_02031	411474.COPEUT_00069	3.26e-143	405.0	COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia	186801|Clostridia	P	domain protein	ktrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
PKFBICOC_02032	411474.COPEUT_00070	5.66e-296	810.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia	186801|Clostridia	P	Potassium uptake protein	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
PKFBICOC_02033	1280694.AUJQ01000014_gene1156	6.83e-90	268.0	COG0406@1|root,COG0406@2|Bacteria,1V25J@1239|Firmicutes,24FZT@186801|Clostridia,3NGMI@46205|Pseudobutyrivibrio	186801|Clostridia	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
PKFBICOC_02034	1392493.JIAB01000001_gene1643	2.8e-84	252.0	COG1335@1|root,COG1335@2|Bacteria,1V1CY@1239|Firmicutes,24HQM@186801|Clostridia,27MPZ@186928|unclassified Lachnospiraceae	186801|Clostridia	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
PKFBICOC_02035	1035197.HMPREF9999_02353	2.88e-25	110.0	COG3680@1|root,COG3680@2|Bacteria,4NJA4@976|Bacteroidetes	976|Bacteroidetes	O	regulation of methylation-dependent chromatin silencing	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_02036	428125.CLOLEP_01742	1.65e-82	248.0	COG2002@1|root,COG2002@2|Bacteria,1V02A@1239|Firmicutes,248XR@186801|Clostridia,3WITH@541000|Ruminococcaceae	186801|Clostridia	K	stage V sporulation protein T	spoVT	-	-	ko:K04769	-	-	-	-	ko00000,ko03000	-	-	-	MazE_antitoxin,SpoVT_C
PKFBICOC_02037	742735.HMPREF9467_03198	1.29e-258	717.0	COG1672@1|root,COG1672@2|Bacteria,1TR21@1239|Firmicutes,24ADD@186801|Clostridia,21ZF4@1506553|Lachnoclostridium	186801|Clostridia	S	ATPase domain predominantly from Archaea	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2,DUF234
PKFBICOC_02038	742765.HMPREF9457_02237	3.05e-196	554.0	COG1457@1|root,COG1457@2|Bacteria,1TTBN@1239|Firmicutes,248EP@186801|Clostridia,27VZ9@189330|Dorea	186801|Clostridia	F	COG COG1457 Purine-cytosine permease and related proteins	cytX	-	-	-	-	-	-	-	-	-	-	-	Transp_cyt_pur
PKFBICOC_02039	411461.DORFOR_02063	1.11e-145	416.0	COG0351@1|root,COG0351@2|Bacteria,1TQ4A@1239|Firmicutes,2483H@186801|Clostridia,27UR1@189330|Dorea	186801|Clostridia	H	Carbohydrate kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
PKFBICOC_02040	536232.CLM_4044	4.34e-41	146.0	COG0637@1|root,COG0637@2|Bacteria,1V1DF@1239|Firmicutes,24FYY@186801|Clostridia,36F85@31979|Clostridiaceae	186801|Clostridia	S	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
PKFBICOC_02041	411468.CLOSCI_03983	5.09e-105	308.0	COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,24DG3@186801|Clostridia,21ZN5@1506553|Lachnoclostridium	186801|Clostridia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
PKFBICOC_02042	1392493.JIAB01000001_gene949	1.4e-159	451.0	COG2145@1|root,COG2145@2|Bacteria,1V1R6@1239|Firmicutes,248AC@186801|Clostridia,27IRB@186928|unclassified Lachnospiraceae	186801|Clostridia	H	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)	thiM	-	2.7.1.50	ko:K00878	ko00730,ko01100,map00730,map01100	M00127	R04448	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HK
PKFBICOC_02044	1195236.CTER_4781	1.41e-10	61.2	COG1396@1|root,COG1396@2|Bacteria,1UVSQ@1239|Firmicutes,25KMH@186801|Clostridia,3WQXA@541000|Ruminococcaceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
PKFBICOC_02045	428125.CLOLEP_03715	5.98e-56	192.0	COG0110@1|root,COG0110@2|Bacteria,1V23V@1239|Firmicutes,24GGM@186801|Clostridia,3WJ74@541000|Ruminococcaceae	186801|Clostridia	S	COG COG0110 Acetyltransferase (isoleucine patch superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	ATPgrasp_ST
PKFBICOC_02046	702450.CUW_1624	1.31e-65	220.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,3VPKC@526524|Erysipelotrichia	526524|Erysipelotrichia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
PKFBICOC_02047	697329.Rumal_1534	4.13e-49	189.0	COG5279@1|root,COG5279@2|Bacteria	2|Bacteria	D	protein involved in cytokinesis, contains TGc (transglutaminase protease-like) domain	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like,LRR_5,Transglut_core
PKFBICOC_02048	411473.RUMCAL_03074	4.09e-28	104.0	COG1609@1|root,COG1609@2|Bacteria,1VADF@1239|Firmicutes,24MXI@186801|Clostridia,3WKHX@541000|Ruminococcaceae	186801|Clostridia	K	sporulation transcriptional regulator SpoIIID	spoIIID	-	-	ko:K06283	-	-	-	-	ko00000,ko03000	-	-	-	SpoIIID
PKFBICOC_02049	435591.BDI_1838	1.44e-192	545.0	COG0399@1|root,COG0399@2|Bacteria,4NFQ8@976|Bacteroidetes,2FMKJ@200643|Bacteroidia,22ZYB@171551|Porphyromonadaceae	976|Bacteroidetes	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.59	ko:K02805	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	DegT_DnrJ_EryC1
PKFBICOC_02050	1410638.JHXJ01000001_gene1756	6.74e-12	64.7	arCOG12654@1|root,330YI@2|Bacteria,1VGQU@1239|Firmicutes,24N61@186801|Clostridia,3WQ3R@541000|Ruminococcaceae	186801|Clostridia	S	HIRAN domain	-	-	-	-	-	-	-	-	-	-	-	-	HIRAN
PKFBICOC_02052	663952.SDD27957_04550	3.11e-28	117.0	COG2207@1|root,COG2207@2|Bacteria,1UZG6@1239|Firmicutes,4HCQS@91061|Bacilli,1M9XV@119603|Streptococcus dysgalactiae group	91061|Bacilli	K	AraC-type DNA-binding domain-containing proteins	bglC	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
PKFBICOC_02053	1232443.BAIA02000143_gene1661	1.13e-117	350.0	COG2378@1|root,COG2378@2|Bacteria,1TSA2@1239|Firmicutes,247S2@186801|Clostridia,26844@186813|unclassified Clostridiales	186801|Clostridia	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	WYL
PKFBICOC_02054	457412.RSAG_02538	1.74e-37	142.0	COG0679@1|root,COG0679@2|Bacteria,1UYFH@1239|Firmicutes,24AI3@186801|Clostridia,3WRXJ@541000|Ruminococcaceae	186801|Clostridia	S	Transporter, auxin efflux carrier (AEC) family protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
PKFBICOC_02055	471875.RUMLAC_02541	0.000996	45.8	2DQHF@1|root,336V9@2|Bacteria,1VIX0@1239|Firmicutes,24T9J@186801|Clostridia,3WKRP@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_02056	658088.HMPREF0987_02627	1.8e-211	597.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia,27I6Q@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
PKFBICOC_02057	1449050.JNLE01000003_gene2028	7.8e-275	788.0	COG0366@1|root,COG3291@1|root,COG0366@2|Bacteria,COG3291@2|Bacteria,1V0U1@1239|Firmicutes,24ZQ4@186801|Clostridia	186801|Clostridia	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
PKFBICOC_02058	398511.BpOF4_18570	2.21e-72	230.0	COG0561@1|root,COG0561@2|Bacteria,1TR16@1239|Firmicutes,4HCZ6@91061|Bacilli,1ZCPY@1386|Bacillus	91061|Bacilli	S	hydrolases of the HAD superfamily	yxeH	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
PKFBICOC_02065	246199.CUS_7883	4.18e-181	525.0	COG1401@1|root,COG1401@2|Bacteria,1TRK1@1239|Firmicutes,24EKG@186801|Clostridia,3WI4A@541000|Ruminococcaceae	186801|Clostridia	V	ATPase associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_02066	877411.JMMA01000002_gene466	5.5e-30	119.0	COG0681@1|root,COG0681@2|Bacteria,1VH6F@1239|Firmicutes,259NA@186801|Clostridia,3WGDR@541000|Ruminococcaceae	186801|Clostridia	U	Peptidase S24-like	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
PKFBICOC_02068	1410617.JHXH01000001_gene722	4.1e-42	152.0	2EV14@1|root,33NG8@2|Bacteria,1VU24@1239|Firmicutes,24Z1N@186801|Clostridia,3WHPM@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_02070	394503.Ccel_2580	1.6e-17	75.1	2EGE3@1|root,33A60@2|Bacteria,1VMF7@1239|Firmicutes,24UMV@186801|Clostridia,36PXP@31979|Clostridiaceae	186801|Clostridia	S	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_02071	411489.CLOL250_01350	9.75e-67	209.0	COG1611@1|root,COG1611@2|Bacteria,1UKED@1239|Firmicutes,24DSN@186801|Clostridia,36GYE@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the LOG family	yvdD	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
PKFBICOC_02072	1321778.HMPREF1982_04106	3.86e-106	330.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,268JM@186813|unclassified Clostridiales	186801|Clostridia	V	MatE	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
PKFBICOC_02073	1688.BCUN_0929	1.58e-79	248.0	COG1708@1|root,COG1708@2|Bacteria,2I2HJ@201174|Actinobacteria,4D03E@85004|Bifidobacteriales	201174|Actinobacteria	S	Domain of unknown function (DUF4037)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4037,NTP_transf_2
PKFBICOC_02074	1120746.CCNL01000017_gene3268	3.66e-90	278.0	COG0196@1|root,COG0196@2|Bacteria,2NPCV@2323|unclassified Bacteria	2|Bacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
PKFBICOC_02075	428125.CLOLEP_01760	6e-86	257.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,3WJNN@541000|Ruminococcaceae	186801|Clostridia	L	Psort location Cytoplasmic, score	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
PKFBICOC_02076	428125.CLOLEP_01759	2.71e-105	316.0	COG2866@1|root,COG2866@2|Bacteria,1TP3K@1239|Firmicutes,249MT@186801|Clostridia,3WHJW@541000|Ruminococcaceae	186801|Clostridia	EM	Carboxypeptidase	-	-	3.4.19.11	ko:K01308	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	LysM,PG_binding_1,Peptidase_M14
PKFBICOC_02077	428125.CLOLEP_03720	0.0	978.0	COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia,3WGJR@541000|Ruminococcaceae	186801|Clostridia	E	Asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
PKFBICOC_02078	203119.Cthe_1399	2.24e-52	171.0	COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,24J98@186801|Clostridia,3WJY6@541000|Ruminococcaceae	186801|Clostridia	S	TIGRFAM C_GCAxxG_C_C family	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
PKFBICOC_02079	428125.CLOLEP_01451	0.0	988.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,3WGRU@541000|Ruminococcaceae	186801|Clostridia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
PKFBICOC_02080	658088.HMPREF0987_00851	2.04e-28	107.0	2DSCR@1|root,33FK0@2|Bacteria,1VKCD@1239|Firmicutes,24QWS@186801|Clostridia,27NWD@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Domain of unknown function (DUF3783)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3783
PKFBICOC_02081	471875.RUMLAC_02584	8.06e-43	154.0	COG0561@1|root,COG0561@2|Bacteria,1U3W2@1239|Firmicutes,2486H@186801|Clostridia,3WJGV@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
PKFBICOC_02082	428125.CLOLEP_03261	8.86e-100	295.0	COG0177@1|root,COG0177@2|Bacteria,1TRAK@1239|Firmicutes,24899@186801|Clostridia,3WGWR@541000|Ruminococcaceae	186801|Clostridia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
PKFBICOC_02083	189426.PODO_29465	7.11e-49	167.0	COG1011@1|root,COG1011@2|Bacteria,1UIG9@1239|Firmicutes,4HX5U@91061|Bacilli,26VJY@186822|Paenibacillaceae	91061|Bacilli	S	HAD family hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
PKFBICOC_02086	428125.CLOLEP_02601	0.0	1046.0	COG0187@1|root,COG0187@2|Bacteria,1TQ6U@1239|Firmicutes,249NI@186801|Clostridia,3WH8Y@541000|Ruminococcaceae	186801|Clostridia	L	DNA topoisomerase	-	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
PKFBICOC_02087	428125.CLOLEP_03191	0.0	1038.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,3WGH5@541000|Ruminococcaceae	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
PKFBICOC_02088	445972.ANACOL_02977	4.03e-55	183.0	COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia,3WJ3Y@541000|Ruminococcaceae	186801|Clostridia	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	HHH,RadC
PKFBICOC_02089	476272.RUMHYD_02454	1.45e-143	407.0	COG0461@1|root,COG0461@2|Bacteria,1TREW@1239|Firmicutes,248WM@186801|Clostridia,3XYW9@572511|Blautia	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
PKFBICOC_02091	428125.CLOLEP_00589	1.47e-175	503.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,3WGV5@541000|Ruminococcaceae	186801|Clostridia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
PKFBICOC_02092	1232449.BAHV02000020_gene1353	4.68e-19	80.5	2E5HW@1|root,33098@2|Bacteria,1VFFD@1239|Firmicutes	1239|Firmicutes	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_02093	1321778.HMPREF1982_00514	5.75e-140	403.0	COG1533@1|root,COG1533@2|Bacteria,1TSS2@1239|Firmicutes,248SB@186801|Clostridia,268M6@186813|unclassified Clostridiales	186801|Clostridia	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
PKFBICOC_02096	1304880.JAGB01000002_gene1652	1.16e-07	60.5	COG5578@1|root,COG5578@2|Bacteria,1V3G3@1239|Firmicutes,24H3P@186801|Clostridia	186801|Clostridia	S	Protein of unknown function, DUF624	-	-	-	-	-	-	-	-	-	-	-	-	DUF624
PKFBICOC_02098	428125.CLOLEP_03121	2.98e-88	270.0	COG0345@1|root,COG0345@2|Bacteria,1TP1E@1239|Firmicutes,247SR@186801|Clostridia,3WGT7@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
PKFBICOC_02099	1121334.KB911069_gene1531	8.45e-08	65.1	COG3772@1|root,COG5492@1|root,COG3772@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	3.2.1.17,3.2.1.89	ko:K01185,ko:K01224,ko:K11904	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.23.1	-	-	Big_2,CW_binding_1,PG_binding_1,Phage_lysozyme
PKFBICOC_02100	553973.CLOHYLEM_06652	9.46e-05	49.3	2DQ8Z@1|root,335CG@2|Bacteria,1V9R5@1239|Firmicutes,24I50@186801|Clostridia,2237K@1506553|Lachnoclostridium	186801|Clostridia	S	Psort location CytoplasmicMembrane, score 9.99	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_02101	428125.CLOLEP_03188	7.74e-61	196.0	COG0484@1|root,COG0484@2|Bacteria,1V1GK@1239|Firmicutes,2494E@186801|Clostridia,3WITE@541000|Ruminococcaceae	186801|Clostridia	O	DnaJ domain protein	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,TPR_2
PKFBICOC_02102	642492.Clole_0404	7.76e-31	124.0	2A16J@1|root,30PCK@2|Bacteria,1UPNY@1239|Firmicutes,25HKA@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_02103	1121874.KB892380_gene1569	2.18e-52	172.0	COG0560@1|root,COG0560@2|Bacteria,1V8Y8@1239|Firmicutes,3VQNW@526524|Erysipelotrichia	526524|Erysipelotrichia	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
PKFBICOC_02105	545697.HMPREF0216_02278	6.7e-66	209.0	COG0546@1|root,COG0546@2|Bacteria,1V4W6@1239|Firmicutes,24C82@186801|Clostridia,36IKK@31979|Clostridiaceae	186801|Clostridia	S	IA, variant 1	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
PKFBICOC_02107	33035.JPJF01000014_gene4811	6.12e-14	66.2	2DJ8W@1|root,30516@2|Bacteria,1TUX7@1239|Firmicutes,25I10@186801|Clostridia,3Y21N@572511|Blautia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_02108	428125.CLOLEP_03205	2.33e-45	150.0	2C5R4@1|root,31VPY@2|Bacteria,1V8EP@1239|Firmicutes,24JPJ@186801|Clostridia,3WJKA@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	TnpV
PKFBICOC_02109	1195236.CTER_1507	1.26e-169	495.0	COG3344@1|root,COG3344@2|Bacteria,1V0M0@1239|Firmicutes,24DGA@186801|Clostridia	186801|Clostridia	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
PKFBICOC_02110	478749.BRYFOR_08202	8.95e-172	488.0	COG4268@1|root,COG4268@2|Bacteria,1TQJI@1239|Firmicutes,24AAV@186801|Clostridia	186801|Clostridia	V	Psort location Cytoplasmic, score	mcrC	-	-	ko:K19147	-	-	-	-	ko00000,ko02048	-	-	-	McrBC
PKFBICOC_02111	1321782.HMPREF1986_01775	1.6e-71	235.0	COG1401@1|root,COG1401@2|Bacteria,1TPIP@1239|Firmicutes,249RD@186801|Clostridia,2PST6@265975|Oribacterium	186801|Clostridia	V	AAA domain (dynein-related subfamily)	mcrB	-	-	ko:K07452	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	AAA_5,EVE,Mrr_N
PKFBICOC_02112	511680.BUTYVIB_00899	4.5e-52	192.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	csn	-	3.2.1.132	ko:K01233	ko00520,ko01100,map00520,map01100	-	R02833	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_46
PKFBICOC_02113	1160721.RBI_I00590	2.1e-128	366.0	COG1309@1|root,COG1309@2|Bacteria,1VE7E@1239|Firmicutes,24Q2X@186801|Clostridia,3WQE9@541000|Ruminococcaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
PKFBICOC_02114	1504822.CCNO01000014_gene1593	7.67e-168	481.0	COG5002@1|root,COG5002@2|Bacteria,2NS51@2323|unclassified Bacteria	2|Bacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
PKFBICOC_02115	411483.FAEPRAA2165_01776	5.48e-124	357.0	COG0745@1|root,COG0745@2|Bacteria,1TSRR@1239|Firmicutes,24AG3@186801|Clostridia,3WH9J@541000|Ruminococcaceae	186801|Clostridia	K	Psort location Cytoplasmic, score	cutR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
PKFBICOC_02116	411483.FAEPRAA2165_01778	1.14e-166	472.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,3WI0F@541000|Ruminococcaceae	186801|Clostridia	C	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
PKFBICOC_02117	742741.HMPREF9475_01908	2.11e-118	351.0	COG0526@1|root,COG0526@2|Bacteria,1UY9A@1239|Firmicutes,24C03@186801|Clostridia,2214Q@1506553|Lachnoclostridium	186801|Clostridia	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
PKFBICOC_02118	1256908.HMPREF0373_00344	1.98e-27	104.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
PKFBICOC_02123	485916.Dtox_1930	5.31e-25	102.0	2E20R@1|root,32X8R@2|Bacteria,1VE8M@1239|Firmicutes,24IA0@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKFBICOC_02125	1408436.JHXY01000010_gene886	3.56e-68	209.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,25WT8@186806|Eubacteriaceae	186801|Clostridia	C	SUF system FeS assembly protein, NifU family	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
PKFBICOC_02126	742733.HMPREF9469_05810	8.84e-199	561.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,21Z26@1506553|Lachnoclostridium	186801|Clostridia	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
PKFBICOC_02127	626939.HMPREF9443_01188	1.17e-88	278.0	COG0719@1|root,COG0719@2|Bacteria,1TRQJ@1239|Firmicutes,4H43G@909932|Negativicutes	909932|Negativicutes	O	SufB sufD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	UPF0051
PKFBICOC_02128	411489.CLOL250_02466	2.37e-295	811.0	COG0719@1|root,COG0719@2|Bacteria,1TQ21@1239|Firmicutes,249IU@186801|Clostridia,36G21@31979|Clostridiaceae	186801|Clostridia	O	FeS assembly protein SufB	sufB	-	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
PKFBICOC_02129	887929.HMP0721_1836	1.14e-125	363.0	COG0396@1|root,COG0396@2|Bacteria,1TQ98@1239|Firmicutes,2489I@186801|Clostridia,25VGE@186806|Eubacteriaceae	186801|Clostridia	O	FeS assembly ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
PKFBICOC_02130	445975.COLSTE_02427	1.11e-43	148.0	COG1959@1|root,COG1959@2|Bacteria,2INF3@201174|Actinobacteria,4CW6P@84998|Coriobacteriia	84998|Coriobacteriia	K	transcriptional regulator, Rrf2 family	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
PKFBICOC_02131	1121334.KB911071_gene2074	8.42e-43	149.0	COG3432@1|root,COG3432@2|Bacteria,1VDQ8@1239|Firmicutes,24R9Q@186801|Clostridia,3WK5T@541000|Ruminococcaceae	186801|Clostridia	K	Domain of unknown function (DUF4364)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4364
PKFBICOC_02132	1120746.CCNL01000013_gene2015	7.72e-09	55.1	2FBQ5@1|root,343V3@2|Bacteria	2|Bacteria	S	SigmaK-factor processing regulatory protein BofA	-	-	-	-	-	-	-	-	-	-	-	-	BofA
PKFBICOC_02133	1105031.HMPREF1141_0303	7.81e-22	87.8	COG1314@1|root,COG1314@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
PKFBICOC_02134	428125.CLOLEP_02604	6.99e-142	426.0	COG0188@1|root,COG0188@2|Bacteria,1TPPU@1239|Firmicutes,24CU3@186801|Clostridia,3WG8X@541000|Ruminococcaceae	186801|Clostridia	L	PFAM DNA gyrase topoisomerase IV, subunit A	-	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
## 1716 queries scanned
## Total time (seconds): 598.9207053184509
## Rate: 2.87 q/s