LOCUS       c00072_gnlPro..        11293 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FHBFGMDF_72.
ACCESSION   c00072_gnlPro..
VERSION     c00072_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 22:55:12
            Original ID  :: gnl|Prokka|FHBFGMDF_72
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11293
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11293
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1420:11292]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /neighbourhood="10000"
                     /product="GR_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1421..11292
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /neighbourhood="10000"
                     /product="GR_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..11293
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /kind="single"
                     /product="GR_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11293
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="GR_AA_metabolism"
                     /region_number="1"
                     /rules="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(275..1219)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AA_kinase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg72_1"
                     /sec_met_domain="AA_kinase (E-value: 4.7e-37, bitscore:
                     116.9, seeds: 128, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFTRKRIVIALGGNALGNTLPEQMVAVKTTAKALCDLIEEGHQVV
                     VVHGNGPQVGMINNAMSALSREDENQPNTPLSVCVAMSQAYIGYDLQNALREELRIRGF
                     VRTPVVTVVTQVRVDPNDPAFENPSKPIGKFLTKEEADHQAKAYGHIMKEDAGRGYRRV
                     VASPKPVEIVEQDAINSLVDANKIVICCGGGGIPVVLNGHHLKGASAVIDKDYASCLLA
                     KELDADMLIILTAVEKVAVNFGKENEEWLDDITVDDAKKYINEGQFAPGSMLPKVQAAV
                     DFASSKEGRTAMITLLQKAKDGIQGKTGTKIHL"
     CDS             complement(1421..2614)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     GR_AA_metabolism: OTCace"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OTCace_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg72_2"
                     /sec_met_domain="OTCace (E-value: 9.9e-50, bitscore: 157.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="OTCace_N (E-value: 2.7e-31, bitscore:
                     97.7, seeds: 1463, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLQDYIDKLNSLNFKEMYNNDFFWTWDKTDDELEAVFTVADAL
                     RFMRENNISTKVFESGLGISIFRDNSTRTRFSFASACNLLGLEVQDLDEKKSQIAHGET
                     VRETANMVSFMADVIGIRDDMYIGKGHAYQKEFMEAVTEGNKDGILEQRPTLVNLQCDV
                     DHPTQCMADMLHIIHEFGGVENLKGKKIAMTWAYSPSYGKPLSVPQGVIGLMTRFGMDV
                     VLAHPEGYDVMPEVEEIAKKNAEKNGGSFTKTNDMAEAFKDADIVYPKSWAPFAAMEKR
                     TDLYAEGDFDGIDKLEKELLAQNAQHKDWACTEELMKTTKDGKALYLHCLPADITGVSC
                     ETGEVDASVFDRYRIPLYKEASFKPYIIAAMIMLSKFENPQDILKKLEVKAAPRILK"
     CDS             complement(2821..4131)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M20"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg72_3"
                     /sec_met_domain="Peptidase_M20 (E-value: 2.3e-25, bitscore:
                     78.6, seeds: 360, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYAKINEAAMGYKDDMTKFLRDLVRIPGESCGEKGHIMRIKEEM
                     EKVGFDKVQIDPMGNILGYMGTGKTLIGFDAHIDTVGIGNIKNWEFDPYEGFESDEEIG
                     GRGTSDQMGGIVSAVYGAKIMKDLGLLNDKYQVLVTGTVQEEDCDGLCWQYIIHEDGVR
                     PEFVVSTEPTDGGIYRGQRGRMEIRVDVKGVSCHGSAPERGDNAIYKMADILQDIRALN
                     ENDAADTTEIKGLVKMLDEKYNPEWEEARFLGRGTVTTSEIFFTSPSRCAVADSCSVSL
                     DRRMTAGETWESCLDEIRALPAVQKYGDDVTVSMYEYNRPSYTDLVYPIECYFPTWVIP
                     KDHKVTQALEEAYKGLYGEERLGNAETEGMRKARPLTDKWTFSTNGVTIMGRNSIPCIG
                     FGPGAEAQAHAPNEKTWKIDLVRCAAVYAALPTAYCK"
     CDS             complement(4276..5505)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     GR_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg72_4"
                     /sec_met_domain="PALP (E-value: 4.1e-52, bitscore: 166.4,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEGLKWTVNEVPKSDDKHLELMSEENVKKANEFHRSFPQYSVTP
                     LQNLSSLAKYLGVKNIFCKDESYRFGLNAFKVLGGSYAMGRYIAKELGRDISELPYNVL
                     SSDKLREEFGQATFFTATDGNHGRGVAWAANRLGQKAVVRMPKGTTKTRFDNIVKEGAT
                     VTIEEVNYDDCVRMAAAEAAKTEHGIIVQDTAWDGYEEIPSWIMQGYGTLVLEADQQLK
                     EMGVERPTHVFVQAGVGSLAGAVVGYFAHKYKDNPPVMAVCEASAADCLYRSAVAKTGN
                     LVNVTGDLQTIMAGLACGEGNTIGWDILKNHVDVFASCPDWMSAKATRIYANPLGDDPH
                     VVSGESGSVPLGFCFTALHDEDAKDLKEALKLDENSVVLVISTEGDTDPVRYREIVWDG
                     LYGTNESLSK"
     CDS             5764..7005
                     /locus_tag="ctg72_5"
                     /transl_table=11
                     /translation="MAVFHAFRALRPTPEKAADVAALPYDVVNREEAKSIGDENPLSFL
                     HIDRPEMDLEPETDLYDDRVYEKAKENLDNMEEKGILVQDQKACYYIYELVRKGKTQTG
                     IVGCSSIDDYMNGVVKKHELTREDKEQDRIHHVDSCNANTGPIFLACRYPDSLLTLMNN
                     WKDHHEAAYDFTEEDQITHRVWVIDEDEVISEINKEFAGIDSLYIADGHHRAASAVKVG
                     LKRREQNPGYTGKEAFNYFLSVVFPYDQLCILPYNRIVKDLNGLTVKAFLGALKFNFEL
                     MLMPGFPCKPVEKHCMGMYVDGQWYHLKAWPDIYEKKDVVGQLDVSILQEKVLRPVLGI
                     EDPRTDQRISFVGGSHKAAELAEIADRTGGVAFVMYPTSMEDLMKIADENKLMPPKSTW
                     FEPKLRSGLFIHKL"
     CDS             7130..7603
                     /locus_tag="ctg72_6"
                     /transl_table=11
                     /translation="VEDAELRNILFSIQGSIAGFQNDMSDVKNDIADMRTDIANMKTDI
                     TNMKADITNMKTDIANMKTDITNMKADITNMKTDITNMKADITNMKSDIVQLKGSVKTI
                     ELKLENEIDRKISALFDARMDELRYRKENKETREKVFELDMRVDNLEKAIMPA"
     CDS             8287..9942
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg72_7"
                     /sec_met_domain="HMGL-like (E-value: 1.7e-76, bitscore:
                     246.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNPSKYQRQYFMPPVKCMKWAEKEYVDKAPVWCSVDLRDGNQAL
                     VIPMSLEQKIEFFKLLVKIGFKEIEVGFPAASETEYEFLRTLIEQNLIPQDVTIQVLTQ
                     AREHIIRKTFEAVKGAPKAIVHVYNSTSVAQREQVFKKSKEEILKIAVDGAALLKKLAD
                     ETEGNFQFEYSPESFTGTEPEYALEVCNAVLDVWQPTADNKCIINLPVTVQHSMPHVYA
                     SQVEYMCENLKYRENVIVSLHPHNDRGCGVADSEMGLLAGADRIEGTLFGNGERTGNVD
                     IVTLGMNMYSQGVDPKLDFSDMPHICEIYEECTGMKVGERSPYSGALVFAAFSGSHQDA
                     IAKGMHWRDDKDPDHWNVPYLPIDPTDVGRNYDADVIRINSQSGKGGVGYILETKFGLN
                     LPPKMREAMGYATKAVSDHKHKELHPDEIFNLFKQTFENITEPYSINEVHFQQKDGGIV
                     TKVTSTFRGKTITTEASGNGRLDAVSNALKKAYELKYSLETYQEHALERSSSSKAIAYV
                     GIKKPDGTLAWGAGVNADIIRASIDALVTAINNR"
     CDS             10348..11292
                     /gene_functions="biosynthetic (rule-based-clusters)
                     GR_AA_metabolism: PFL_acetate2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg72_8"
                     /sec_met_domain="PFL_acetate2 (E-value: 2.2e-124, bitscore:
                     405.1, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNFEQWNGFKGNRWKEKIDVRNFIGMNYTPYDGDASFLEGPTEA
                     TNKLWGKLQALQKEERAKGGVLDMETEVVTSLTAYGPGYIDEETKDLEKVVGLQTDKPL
                     KRAFMPYGGIKMAEQACETYGYKVSDKIKDVFHNYEFKTHNQGVFDIYTPEMKVARHNK
                     ILTGLPDTYGRGRIVGDYRRVALYGIDALIEGKQKDFAACDRQGMRRYDFQLREEIADQ
                     IRALKGMKVMAESYGYDISKPAKDAREAFQWLYFGYLAAIKTQNGAAMSVGRISTFLDI
                     YIERDLQNGTLTEKEAQELVDHMVMKFRMVKFAR"
ORIGIN
        1 tggtatagtt atttcgaaaa cgatgtacta gagcgtgtct gaaaaatgct ttccgcaaga
       61 tgtatgtcaa aatataccga aaagtggggc gtgcagattg caggaatgat tttccagaca
      121 ctctggtcca ctcatcacaa aaaaagttcc gggcgaggtc accggaactt tttttgcgca
      181 attattttgc tatatggcag atatcctgaa tatgtggcag ttatatatat cagtattaaa
      241 cagctgatat ataataagat atctgctgaa cagattaaag atggattttg gttccggttt
      301 ttccctggat accgtctttg gctttctgaa gtaaagtgat catggcagtt cttccttctt
      361 tggagcttgc aaaatcaacg gcagcctgaa ctttcgggag catggaacct ggggcaaact
      421 gtccctcatt aatatatttc ttagcgtcat ctacagtgat gtcatccagc cattcttcgt
      481 tttccttgcc gaagtttaca gcaaccttct ccactgctgt aagaatgata agcatatctg
      541 catccagctc tttggccagg agacagcttg cataatcctt atcaataact gctgatgcac
      601 ctttgagatg atgtccgtta agaacaacgg gaattccgcc gccaccgcag cagataacga
      661 ttttatttgc atccacgaga ctgttgatcg catcctgttc aacgatttca acaggctttg
      721 gagatgcaac tacacgacga taaccacgcc ctgcgtcttc tttcatgata tgtccatatg
      781 ccttggcctg atggtctgct tcctcttttg tcaggaattt gccgatcggc ttggatggat
      841 tttcaaaagc aggatcattg ggatctacac gaacctgagt gacaacagtg acgacaggtg
      901 tgcggacaaa tcctctgatt cgaagttcct ctctcaaagc attctgcaga tcatatccga
      961 tgtaagcctg actcatggca acacagacag agagaggagt gtttggttga ttctcatctt
     1021 ctctggagag agcagacatg gcattgttga tcatgccaac ctgtggcccg tttccatgta
     1081 caacaacaac ctgatgacct tcttcgatca gatcgcataa tgcttttgca gtagttttta
     1141 cagctaccat ctgttccggg agagtatttc ccagagcgtt cccaccgagc gcaataacga
     1201 ttctttttct tgtaaacatt tgtaaaaacc tcctgatttt aaaggcaaag agggccgccg
     1261 caataaagat tgtgtgcttt ctgcgacagc cccgcctgct atacaatatg atgagtacta
     1321 tttttcaata tatttaaatt ctgaaactgc tttcaaaatt aaatatctgt ttgaaagcag
     1381 ctggaatatt actgcaatcc aactgttaat ctgcgcctga ttatttcagg attcttggag
     1441 ctgctttgac ttcaagtttc ttcaggatat cctgtggatt ttcaaatttg gaaagcatga
     1501 tcatagcagc gatgatgtat ggtttgaagc ttgcttcttt gtataacggg attctgtaac
     1561 gatcgaatac agaagcgtca acctcacctg tttcgcagct tacacctgta atatcagccg
     1621 gcaggcagtg caggtaaaga gcttttccgt cttttgttgt tttcataagt tcttctgtgc
     1681 aggcccagtc tttgtgctgt gcattctgtg caagaagttc tttctctaat ttatcgattc
     1741 cgtcgaagtc gccttctgca taaaggtctg tacgtttttc catagctgca aatggagccc
     1801 agctctttgg atatacgata tcagcatctt tgaaagcttc agccatatcg tttgtttttg
     1861 tgaaagatcc gccgtttttc tcagcattct tcttggcaat ctcttcaact tccggcatta
     1921 catcatatcc ttccggatga gcaagaacaa cgtccatgcc gaaacgtgtc atcagaccga
     1981 taacgccctg cggaacggag agtggtttac cataggatgg agagtaagcc catgtcatag
     2041 cgatcttttt gcctttcaga ttctcaacac cgccgaattc atggatgatg tgcagcatat
     2101 ctgccataca ctgtgtcgga tggtcaacgt cgcactgaag gtttacaaga gtaggtctct
     2161 gctcaaggat accgtctttg tttccttctg taacagcttc catgaattct ttctggtaag
     2221 catgtccttt tccgatgtac atatcatcac ggataccgat cacatcagcc atgaaagaca
     2281 ccatgtttgc tgtttcacga acagtttcac catgagcgat ctgagatttc ttttcatcaa
     2341 gatcctgtac ttccagacca agaaggttac atgcggaagc aaaagagaaa cgtgtacgtg
     2401 tggagttatc gcggaagata gagattccaa gaccactctc gaatactttt gtggagatat
     2461 tgttttctct catgaaacgg agagcatcag caactgtgaa aacagcttcc agttcatcat
     2521 ctgttttgtc ccatgtccag aagaaatcgt tgttgtacat ttctttgaag tttaagctgt
     2581 ttaatttatc aatgtaatcc tgtaatgttt tcataaaatc aatacctgct atgctttgat
     2641 agcttatcct ttcctgatat gaaataattg aatctctgcg tttggcagaa caccggttat
     2701 ccggctgtat ctgtttatct tgtgtccctg cctgttacag cagggattct gtccggacac
     2761 atattaagcc tttaggatga taggaaatcc gtcgcctaaa aaaatttgaa aatttattta
     2821 ttatttgcag tatgcagttg gaagagcagc gtatacagca gcgcatctta caaggtcgat
     2881 cttccatgtt ttttcgttcg gagcatgagc ctgtgcttct gcaccaggtc cgaatccgat
     2941 acaaggaatg ctgttacgtc ccatgattgt tacaccgtta gtagagaatg tccatttgtc
     3001 tgtaagcgga cgagcttttc tcatgccttc tgtctcagca tttccgagac gctcttcgcc
     3061 gtacagtcct ttatatgctt cttccagagc ctgtgttact ttgtgatctt tcggaattac
     3121 ccatgtcggg aagtagcact cgatcggata tacaaggtct gtataggacg gacggttgta
     3181 ttcatacatg gatactgtta cgtcgtcgcc atatttctgt acagccggaa gagcacggat
     3241 ctcatccagg cagctttccc atgtttcgcc tgctgtcata cgacggtcaa gagatacaga
     3301 gcaggagtca gctactgcac agcggcttgg ggatgtgaag aagatttcgg aagtagtaac
     3361 agtgccacgt ccaaggaaac gtgcttcttc ccattcaggg ttgtatttct catcaagcat
     3421 ttttacaaga cctttgatct ctgtggtatc agcagcatcg ttttcgttta atgcgcgaat
     3481 atcctgaaga atatcagcca ttttgtagat tgcattgtca ccacgttccg gagcggaacc
     3541 atggcaggaa acccccttta catctacgcg gatttccata cgtccacgct gtcctctgta
     3601 gataccgccg tctgttggtt ctgtggaaac aacgaattca ggacgaacac catcttcatg
     3661 gatgatgtac tgccagcaga gaccgtcaca gtcttcttcc tgtacagtac ctgtcacaag
     3721 tacctgatat ttatcgttta aaagaccaag gtctttcatg atcttagcac cgtatactgc
     3781 agaaacaata cctcccatct ggtcagatgt tccacgtccg ccgatttctt catcagattc
     3841 gaaaccttcg tatggatcaa attcccagtt cttgatatta ccgataccga ctgtatcaat
     3901 atgagcgtca aaaccaatga gagttttacc tgttcccatg tagccgagga tattgcccat
     3961 cggatcgatc tgaactttgt cgaatccgac tttttccatt tcctctttga ttctcatgat
     4021 atgtcctttt tctccgcagc tttcgccagg aatgcgaacc agatcgcgaa ggaacttagt
     4081 catatcatcc ttataaccca ttgcagcttc gttaattttt gcgtaatcca ttttttaccc
     4141 tcccaatatg tataaaatat tatgatgtta gggtcaaaag gtattttgcc cctaatctga
     4201 tatcatatta ttagttactg gtatatcatt ttcgagataa ccatactact tacctgtctg
     4261 tgttcaccaa aaacatcatt tgcttaaaga ttcgtttgtt ccgtataatc cgtcccatac
     4321 gatctcgcgg tagcgaacag ggtcagtgtc accttctgtg gaaataacaa gtactacgga
     4381 attctcatcc agtttcagcg cttcttttaa gtcttttgca tcttcatcgt gaagagcagt
     4441 gaagcagaaa ccaagcggaa cggaaccgga ttcaccggag acaacgtgtg gatcatctcc
     4501 cagtggatta gcgtagatac gtgttgcctt tgcgctcatc cagtcaggac aggatgcaaa
     4561 tacatctacg tgatttttca ggatatccca tccgatcgta tttccctcac cgcatgcaag
     4621 accggccata attgtctgaa gatcacctgt aacatttacc agatttcctg tctttgcaac
     4681 agcggagcgg tacaggcagt cagcagcact tgcttcacag acagccataa ccggcgggtt
     4741 atctttatat ttatgagcga aataaccgac tacggcacct gctaaagaac caacaccggc
     4801 ctgaacaaat acatgtgtcg gacgttcaac acccatttct tttaactgct ggtcagcctc
     4861 aagaaccagt gttccgtatc cctgcatgat ccaggatgga atttcttcat atccgtccca
     4921 tgcggtatcc tgaacgatga taccatgttc tgttttggca gcttctgctg cagccattct
     4981 tacgcagtca tcatagttta cttcttcgat cgtaacagta gcaccttctt tgacaatgtt
     5041 atcgaaacga gtctttgttg ttcccttagg cattcttaca actgctttct gtccaaggcg
     5101 gttagctgcc catgcaactc cacgtccatg attaccgtct gttgcagtaa agaatgtagc
     5161 ctgtccgaat tcttctctta atttatcaga agagagaaca ttgtatggca gctcgctgat
     5221 atcacgtcca agttcttttg cgatatagcg gcccattgca taagaacctc caagtacttt
     5281 gaaagcattt aagccaaagc gataggattc atccttacag aaaatatttt ttactcctaa
     5341 atatttcgca agggatgaaa ggttctgaag aggcgtcaca ctgtactgtg ggaaacttct
     5401 gtggaactca tttgctttct ttacattttc ttcggacatc agttccaggt gtttatcatc
     5461 tgatttcgga acctcgttta cagtccattt taatccttct gtcataaaat gacctccctt
     5521 aaaaattatc atttggtttc cttaacttgt gattctatca taccatatat tttaaaaatt
     5581 gcaatagaaa aatacaaaaa tttttaggtt tttcaaaaaa aaattaggtt tcataatttg
     5641 tacattgata taaggatttg gatatgataa aataatgagt aatgttcgtt ttatttttac
     5701 aggatagaca gtaaagtggg tataaaagag caataaaaaa gatacagaag aggagaaaat
     5761 attatggcag tatttcatgc attccgggca cttcgaccta caccggaaaa ggctgctgat
     5821 gtggcagcac ttccatatga tgtggtaaac cgggaagaag caaaatcaat cggagatgag
     5881 aatcccctgt cctttcttca tattgacaga ccggaaatgg atctggaacc tgagacagat
     5941 ctgtatgatg atcgggttta tgaaaaagca aaagaaaatc ttgacaatat ggaagaaaag
     6001 ggaattcttg ttcaggatca gaaggcctgt tactatatat atgaacttgt aagaaaagga
     6061 aagacacaga ccggtatcgt aggatgcagt tccattgatg attatatgaa tggtgtagtg
     6121 aagaaacatg agcttaccag agaagataag gagcaggaca ggatccacca tgtagattcc
     6181 tgtaatgcaa ataccggtcc tatttttctg gcatgcagat atccggattc tctgcttaca
     6241 ctgatgaata actggaaaga tcatcatgaa gcagcatatg attttacaga agaggatcag
     6301 atcacacaca gagtatgggt gattgatgaa gatgaggtca tttctgaaat aaataaggaa
     6361 tttgcaggga ttgattctct gtacatcgca gatggacatc accgcgcagc ttccgctgta
     6421 aaagtaggtt taaagagaag agaacagaat ccgggatata cagggaagga agcgtttaat
     6481 tatttcctgt ctgttgtatt tccctatgac cagctctgca ttcttcctta taacaggatt
     6541 gtaaaagatt tgaacggcct gactgtaaag gcatttctgg gcgccctgaa gttcaacttt
     6601 gaactgatgc tgatgccggg atttccatgc aagcctgtag agaagcattg tatgggaatg
     6661 tatgtggacg gacagtggta tcacctgaaa gcatggccgg atatctatga gaagaaggac
     6721 gtggtcggac agctggatgt atccattctt caggaaaaag tcctcagacc agtcctggga
     6781 atcgaagatc cgcgcacaga ccagagaatc tcctttgtgg gcggaagcca taaggcagca
     6841 gagctggcag agattgcgga cagaaccggc ggtgtagcct ttgtcatgta cccgacatct
     6901 atggaagacc tgatgaagat tgcagacgag aacaaattaa tgcctccaaa atccacctgg
     6961 tttgagccaa agcttcggag tgggctgttt atacataaat tataatttgc cgaagatgtc
     7021 ttataaaaat attataataa tttcgctgta gactttttct tccttcaatg gtacaattgg
     7081 ttctatacag aagagaacga gacgtactat aacgaaagga gggaagaatg tggaagatgc
     7141 ggaattgaga aatatccttt tttctataca gggaagcatt gccggttttc aaaatgatat
     7201 gtccgatgta aagaacgata tcgcagatat gaggacagat attgcaaaca tgaagacgga
     7261 tatcacgaac atgaaggcag atatcacaaa catgaagaca gatattgcga acatgaagac
     7321 ggatatcacg aacatgaagg cagatatcac aaacatgaag acggatatca caaacatgaa
     7381 ggcagatatc acgaacatga aatcagatat tgtgcaactc aagggaagcg taaaaactat
     7441 agaacttaaa ctggaaaatg aaattgacag aaaaatatct gccctatttg atgcacgtat
     7501 ggatgagctt cgctatagaa aagagaataa ggaaactcgc gagaaagttt ttgaactgga
     7561 tatgcgtgta gacaatttgg aaaaagccat catgccagcg taactgtaac agatgattgt
     7621 aaggcttgta cataggataa acaggaagaa attttataac ataaaaagta catgaaattt
     7681 cttcctgcta aatttgtata atttttgtaa atttttcaaa aaacagttga aatcacagaa
     7741 ataatttgtt atactaactt gcgttacggg gtatggcgta gcttggtagc gcgcacggct
     7801 gggggccgtg aggtcgcagg ttcaaatcct gttgccccga ctgacatatg gttaaatcgt
     7861 ttgtagtata tttacaatga atgattcaga cgtatgttca ttttaaaaaa gccaaataaa
     7921 gttataagta aaatgcaatg ataaggaata gtacacccgg accggagcac agagaactgc
     7981 tggttgctga gaagcagtgg aaggaaattg tggaactcgc ctttgagcag ctgcctgaaa
     8041 ttatacaaga gtaggtgcag acggtttcca ccgttatatg gagaggatat aagaataccg
     8101 gatatccgga gattccgtat cccatgagtg tatgacattg ttcataaata agagtggtac
     8161 cgcgtaagat gataatatct ttcgtctctt gcagataagt ctgtggagat ggaagatttt
     8221 tttatgtctt tttacagtca atccccacag tccaaacata atatttacat aacggaggaa
     8281 gaaaaaatga tgaatccaag caaatatcag agacagtatt ttatgccgcc tgttaaatgc
     8341 atgaaatggg cagaaaaaga atatgtggac aaagcacctg tctggtgttc tgtagacctt
     8401 cgtgacggta atcaggcact ggtgattccg atgagtctgg aacagaaaat tgaattcttt
     8461 aaacttcttg taaaaatcgg tttcaaagaa attgaagtag gtttcccggc tgcttctgaa
     8521 acagaatatg aatttctgcg taccctgatc gagcagaatc tgatcccaca ggatgtaact
     8581 attcaggttc tgactcaggc cagagagcat atcatccgca aaacttttga agctgtcaaa
     8641 ggcgcaccga aggcaattgt acatgtgtac aattccacct ctgtagctca gagagaacag
     8701 gtatttaaga aatccaaaga agaaatctta aagattgcag tggatggtgc cgcattatta
     8761 aagaaactgg ctgatgaaac agaaggaaat ttccagtttg agtacagccc tgaaagcttt
     8821 acaggcacag aaccggaata cgctctggaa gtatgcaatg cagttcttga tgtatggcag
     8881 cctacagcag ataacaaatg catcatcaat ctgcctgtaa ctgtacagca ttccatgccg
     8941 catgtatatg caagccaggt agaatatatg tgtgaaaatc tgaaataccg cgagaatgta
     9001 atcgtatctc tccatccgca caatgacaga ggatgcggtg ttgcagattc tgaaatggga
     9061 ttacttgcag gtgcagacag aatcgagggt actctgttcg gaaacggtga gcgtaccgga
     9121 aatgtagata ttgttacact tggtatgaat atgtattctc agggtgtaga tccaaaactt
     9181 gacttctctg atatgccgca tatctgtgaa atatatgaag aatgtaccgg aatgaaagta
     9241 ggcgaaagaa gtccgtacag tggtgcactt gtatttgccg cattttccgg ctctcatcag
     9301 gatgcaattg ccaagggtat gcactggaga gatgacaagg atccggatca ctggaatgtt
     9361 ccgtatcttc cgattgaccc gacagatgtg ggaagaaatt atgacgcaga tgttatccgc
     9421 atcaacagcc agtccggtaa aggtggcgtg ggatatatcc ttgagaccaa attcggtctt
     9481 aaccttcctc cgaaaatgcg tgaggcaatg ggatatgcca caaaagctgt ttcagaccac
     9541 aaacataaag agcttcatcc tgacgaaatt ttcaatctgt ttaaacagac ctttgagaat
     9601 atcacagaac cgtacagtat caatgaagta catttccagc agaaagatgg cggtattgta
     9661 acaaaagtta cctctacttt ccgcggaaag acaatcacta cagaggcatc cggtaacgga
     9721 cgtcttgatg cagtcagcaa tgcactgaag aaggcatatg agctgaaata ttccctggaa
     9781 acatatcagg agcatgcgct ggagcgcagt tcaagttcca aagctattgc ttatgtcggt
     9841 atcaaaaagc cggatggaac ccttgcctgg ggtgcaggcg taaacgcgga tatcattcgc
     9901 gcatctattg atgcacttgt aacagcgatc aataaccgtt agattgttcc gacacgcccg
     9961 attttttcct gctgtttttt gacttctgca ggtcagacta atatccgctt ggcagggaat
    10021 aatatagttt acataaaata tcaaaaatca gataccggtc agattgtcca gaggacttcc
    10081 tgaccggtat ttttttgtat ttataaaaat acaagaaagt cttaatgtac gcgataaagt
    10141 acaataaaga agcaaactcc gatgaaaagc tatcagaatt gtatttaatt aaaatcataa
    10201 aggaaattaa ttgacataac actcatgttt acgtatactg acagcgtggg cagaaaagtg
    10261 tcctaaataa gtacaattta cattttatta tctcactcca ggccagtgag aaatgcgcgg
    10321 aaatatttta gagaaagagg taaaagaatg aaaaatttcg aacagtggaa tggctttaag
    10381 ggcaaccgtt ggaaagaaaa aatcgatgta cgtaacttta ttggaatgaa ctatacacca
    10441 tatgacggtg atgcttcttt cctggaagga cctacagaag ctacaaacaa actgtggggc
    10501 aagctccagg cacttcagaa agaagaacgt gccaaaggcg gagttcttga tatggagaca
    10561 gaggtagtta catctctgac agcatatggt cccggatata ttgatgaaga aacaaaagac
    10621 cttgaaaaag ttgttggtct tcagacagat aaacctctga aacgtgcttt catgccatac
    10681 ggcggtatca aaatggcaga gcaggcttgt gaaacttatg gatataaagt aagtgacaag
    10741 attaaagatg ttttccacaa ctatgaattt aaaactcaca accagggtgt atttgatatc
    10801 tacacacctg agatgaaagt agcacgtcac aacaagatcc ttacaggtct tccggatact
    10861 tacggacgtg gacgtatcgt tggcgactac agacgtgtgg ctctgtacgg aatcgacgct
    10921 ctgatcgaag gaaaacagaa agacttcgca gcatgcgacc gtcagggtat gagacgttat
    10981 gacttccagc ttcgtgaaga gatcgctgat cagatccgtg ctctgaaagg catgaaagtt
    11041 atggctgaat cttatggata tgatatctcc aaaccggcca aagatgcaag agaagctttc
    11101 cagtggctgt acttcggata tcttgcagcc atcaaaactc agaacggtgc tgcaatgagt
    11161 gtcggacgta tttccacatt ccttgatatt tatattgaaa gagatcttca gaacggaact
    11221 cttacagaga aagaagctca ggagcttgtt gaccacatgg taatgaaatt ccgtatggtt
    11281 aaatttgcac gta
//
