LOCUS       c00012_gnlPro..        23228 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AHIEHJEE_12.
ACCESSION   c00012_gnlPro..
VERSION     c00012_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 17:44:07
            Original ID  :: gnl|Prokka|AHIEHJEE_12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 42992
            Orig. end    :: 66220
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..23228
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[52992:56220]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13228
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..23228
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..23228
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(528..1676)
                     /locus_tag="ctg12_43"
                     /transl_table=11
                     /translation="LEKKKFRISGKLIFNLAVVAISIYLIIYFFVSEDGLIDLLKKPDG
                     CNMLIILAALLIYDLNILVDAVVTLIYVRSKYKDFSFIEALKVAFVGVFFSAITPSSTG
                     GQPMQLYLMSKKNISVGFGSACMTQKFIVYQIVMTAVSVIAVITRFNYFSDAFTNIWST
                     LFIAFGFTVQLAMTALFLLVSFSRKVTNKLINLIYKIMKKFKFIKNPEKKVERLQKEVD
                     MFHDTNKQLFSSVKRLVVIYVLVFIQVLLILSIPYLIYISFGMAPIARAAGQPTLSFYD
                     SICIQSFVLFTANLIPLPGASGGAELAFTMYFGSFFKIGAISKIKPAILMWRFITYYGA
                     ILISAPFSYFTKGKRRDDEIKQIEEELESEMKNKKSEEKLTQ"
     CDS             1973..2506
                     /locus_tag="ctg12_44"
                     /transl_table=11
                     /translation="VDTMSVNGKAFAVIKLLGKGKGGYSYLVSDGEHNYVLKQIHHEPC
                     SYYTFGNKIQSELNDYERLKNAGLRLPKLIDCDVENERILKDYIDGKTAYELVLQNEMK
                     PEYIEQVREMCRLLNPKGINIDYFPTNFILNNGLLWYIDYECNDYMEEWNFENWGIKYW
                     SKTKEFCEYHENNK"
     CDS             2519..2977
                     /locus_tag="ctg12_45"
                     /transl_table=11
                     /translation="MDFFSTNLFNWYGLAFAIALLVPDIVYIKSNRIDRTIFDNRAMLY
                     IERIGKYCSIFLMGINIGVLEGGFTKPIMETFWIISTCVLTVVALILWFLCFNRFSKLW
                     AYLLTAVTAVIFMMSGLLQVKTLLLTAGVVYLIGQLYVTNKYVKSKMQ"
     CDS             3077..3475
                     /locus_tag="ctg12_46"
                     /transl_table=11
                     /translation="MNVIMLLKHKDSLKYIYEDNTLRQGLEKMRAHSYTAIPVITRDGK
                     YVGTVSEGDFLWHIIDKKTSGDIEEQEEFRIRDILRPDFNPAVKISVGMDELLARAMNQ
                     NFIPVTDDLGTFIGIVTRQDIIRYFVNK"
     CDS             3495..4289
                     /locus_tag="ctg12_47"
                     /transl_table=11
                     /translation="MLKIASAVLVMAETEFLIYRNLHINFRLMYYNQSTVRKMYNILLV
                     EDDKNIREMLVEYFSKRDKDKFNITLAENGLKGLDKAYENSYDLLLLDVMLPEMDGFTL
                     CKEIRRYSDVPIMFITARTSEADMLNGYALGCDDYIVKPIALPVFYEKVKALIKRSKGL
                     VRHNLLTVGNVSLNPNNGVVVSDGEEVTLTAKEYAILKILLENKNSVVSREKIITAVWH
                     YDTMIDERVLDTHIKNIRKALGENASVLKTVIRRGYKAEDKK"
     CDS             4286..6004
                     /locus_tag="ctg12_48"
                     /transl_table=11
                     /translation="MKSRYIKRRKKFHYIIISVTIIVCLLGTVFTSLAILNSSKDLLVA
                     NAENELKMKMIDLEHNLGINLTDSQDDKVNGAYPYNDKVGLLNENVDKSNTYYQVTDKK
                     NLTITTDNVLTVYYISSNRNYISFDVIKNLLSDNEYKEICGYLNTPTDNDGNYYVLICK
                     KFYESEKYGYVPCQLEVVKTNKVNDWYVQDEVVKTYSFDLSKYDYLTIEELEATPFEND
                     EMHRNIIDKDFFLGKDKPKYSQKNVEQILKDNALSYIDIYESPAVVNDGIFKCYLLSSD
                     YYYNKENRLISDLDDSDYVYKVVQGSYLIVSLKEIDLLNDCLWKFITVFAVAFTIMAVV
                     ITVEIFSWKDFKRRTAQEETRLEMTNAIAHNLKTPLFVIGGFAENLKNEEDTEKKLHNI
                     EIIQQQTEEMDILIHRMLDLSRFDSPALKLNCEVFDFKPFIEKILENYYVHTEHEIIFI
                     YNSKAKIKADSAMLKTVLENLIDNAEKYSDYGSDITINVSDDVLSISNQCSSFDRENLS
                     KLWQPYFRAAKGDNKSGSGIGLSIVKSALEMHGFKYKAEFENGIITFKFRFTSLD"
     CDS             6612..7766
                     /locus_tag="ctg12_49"
                     /transl_table=11
                     /translation="MKKVMSFAIVLMLAFSCVFTAFAQTDDTATPDEAKKVTELKITKL
                     PDKLTYTAEDVIDPDIDLSKIADENATEESLIKYFSQFNFELKLDLTGIEVEAVYSDGT
                     TEKVDAKDCKAELADPFNYGEAIKALLEYEKNMPDFTEDMTEDEFEKIVTELNSKLYGM
                     IYREYTVNVSYQDAQTSYKIKFENINDVPQLDERYEVVSVKAPEKVNYTKADTDFFYEA
                     DMPYDGSPESKEYYDETYFYPEFKGLEVTVKDKITGKTYTKTFDGTEEDIVYISPVDVR
                     PDDTKTNLEVYVMGDVNEWLNLPEDEEYSTEVTGTFKVNYYANGVPSKGNSSTNDTATK
                     DTPSNSQNNSGAVQTGQNSVAIFLAAAMLAGCGVIFAKRRTRFE"
     CDS             8020..9813
                     /locus_tag="ctg12_50"
                     /transl_table=11
                     /translation="MSAVAVSAVSANAVEPLNTPVQYAQVARASFATPKISKAESVYGG
                     VKLTWNKVNGAAKYRVYYKGRKGWTRMVDTTSTSYIDKDVSSGRNYTYTVRCISADGKS
                     FTSGYDSKGTTVKYVAAPEISKLENVNGGVKISWGKVSGATKYRVYYKGSKGWTKMVDT
                     TSTSYTDKDVSSGRNYTYTVRCITSDAKKFTSGYNPTGKSVKYVATPKISKLEVTYDGV
                     KLTWNKVAGAEKYRVYYKDRNGWTKLGYTTGTTMLDMNVVSKEFDLSVDDIYYTVRCIS
                     KDAKSFTSGYDSKGKPIGDHQDCPEIYSIGAVKNGVEMHWTGDAPKFRVYIKENGSWKK
                     IAETYDNHYVHKGAKSGSNTYTVRGVSKDGKKFTTMFNPTGVTYRYKTSDKTRDAFINY
                     MMNHTDEWMPSLGSNHNLSGIMFLDFDFDGVPELVAQKSDSKEYGFHSVVYKFEDGKLK
                     RVGNVNDGFSIYYNKTAKKYEVHDLKISLNVDDGYYWSGNSIITYDGENLFANMYSSRG
                     VVEESNNIYYRYFDGNDKNISRAKYNEINLKQFNNCVNAHMFTEFIATGYGDTSAWGEK
                     TTAENKQSLLDAYNSFSYEKY"
     CDS             complement(10001..11041)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_51"
                     /sec_met_domain="IlvN (E-value: 2.4e-83, bitscore: 269.8,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3e-60, bitscore: 194.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLR
                     DSGCDVIVGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKIAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(11102..11593)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_52"
                     /sec_met_domain="ALS_ss_C (E-value: 2.3e-29, bitscore:
                     93.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQEPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRVNTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             complement(11606..13228)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_53"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-42, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKIYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNEEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             complement(13425..14666)
                     /locus_tag="ctg12_54"
                     /transl_table=11
                     /translation="LKKIFLLLVTALFLLSLYGCNTSSSSNNSTEQTTVTDTDDLSLDS
                     DIETTELNHNLEIYNNGKKVDTLNLYGLFKQIDNGFIYSKINKDSPNEMEYYRYYLDKK
                     SSVKLGSIKDWSMQIHDKAYVNNHLCFTASTGDITDEENRTLEFIDIDLNKNKMTTVFS
                     DKGGFPYDTVTGADNLVIITKVLNNGTSLELYDTETQKFKQLKYLEFDDKNSIGETIRK
                     VSIDKSTKTISLLVLDCISQNEASLKIETYDYNMNFQKSYDISNISDDSNELIQGVQEF
                     DFKNNYLFYQNFSITRCIGYIDSDKLKKSDISEDVDDTFSIVSASEDDSDTNLLYKRAE
                     SSSEDNYIYLFDTTNKTMKETKFNIEEKGYTIGSISRIGKDNLMIMMSPDNADEKSDLN
                     ARIYFTKLSDLNFQ"
     CDS             complement(14865..17189)
                     /locus_tag="ctg12_55"
                     /transl_table=11
                     /translation="MRYKYQLDNLNCAHCAGKIEAKIAETDGFEDVSFNFATKLLNFKS
                     ERQNPVSEIQAICDSIEDGVTVVDKTPKTNLKKYTYTLDNLNCAHCAGKIEAKIAETNG
                     FEDVSFNFATKLLNFKSEKQNPVSEIQAICDSIEDGVTVVDKTPKNDITTKAEPEITKK
                     KINRDTIFLAISIVLAVVSEILHLTLDGVTAVHYVVLAACFVATLLSGYKVFIKGAKNI
                     LKLRIDETTLMAVAVITAFCLGDFVEAAMVTILFSIGEIFEDRAVDASRRDIEKLANIR
                     PDTATIIVDGAEQIVPAESVEIGSIIEVKPYERVPLDGIIIKGKTTLDTSALTGESLPV
                     DAGEGSEVLSGAINGSNLITVKTTKHFGDSTATRILQLVEDAAAQKGNSEKLISRFASV
                     YTPVVVLIAAAIAVIPPLCGLGAFSEWLYRALVCLVASCPCAIVISVPLSYYSGIGAAS
                     EVGVLIKGGKYIEALAKADTFVFDKTGTLTSGKLSVNKVNTVGSYSADEVLALAAASEK
                     YSAHPIASAIREKANGLELPELSDYSESAGHGTSAVYNGKTIQCGGSKILSDEQKKIAN
                     KDDSVFVIYDGQLIGSLNVSDTVRPEAKEVISQLKALGVKNTVMLTGDRQQPAENVKNE
                     LGLSECHAELLPAQKLELFKGLKSKSKGACFVGDGINDAPVISASDCGIAMGFGSEAAI
                     EASDAVLASGTLKQLPKAIKIARSVINTVKGNIIFALSIKALVIILAAFGLAQIWMSVI
                     ADTGVSVVCVLIAARLLKKKY"
     CDS             complement(17200..17517)
                     /locus_tag="ctg12_56"
                     /transl_table=11
                     /translation="MENKEKTTTPEMPDIDVLFELADLFKVFGDSTRLRIMYTISENEM
                     SVLNIAEALSMEQSTISHQLRVLRQNKLVRVRREGKQIYYSLDDDHVKRIIEMGLDHVL
                     E"
     CDS             18237..19529
                     /locus_tag="ctg12_57"
                     /transl_table=11
                     /translation="LEKFVVTGGKPLSGEVTISGAKNAAVAIIPAVILCDEPCQIENIP
                     NISDVSLISRILQQMGANVRRINRSSLYIDPTKIRTCNAVTDLVRGMRASYYLLGALLG
                     KYGRAKVALPGGCNFGVRPIDQHLKGFEALGAATQLVDGAIIEAECDNLVGTHVYLDVV
                     SVGATMNIMLAASKAKGQTIIENAAREPHIVDLANFLNSMGADVRGAGTDVIKIRGVEY
                     LHGVTYSIIPDQIEAGTYMCAAAATRGCITVKNITPKHLESISAKLREMGVKITEYDEA
                     LKVDASSAPLKRCNIKTMPHPGFPTDCQPQFAALLMSVPGTSIINENVWDNRYQYVSEL
                     IRMGAQISVEGRLAIIEGGTPLTAAPVKATDLRAGAAMIIAALEINGTTEISNIQFIER
                     GYEDVVEKFRGLGADIKKVYFTGDNEQELGA"
     CDS             19654..20442
                     /locus_tag="ctg12_58"
                     /transl_table=11
                     /translation="LARAVPLFSGSKGNSYYIGSATEGVLIDAGRSCKQIENAMLANGL
                     DMSSIGAVFITHEHTDHCSALRVLAKRYGFKVYSSLGTLNALRAGNKLDPNTDADVITD
                     EVVIGNMRVQRIDTPHDAAESCCYRVTAPDGKSALIATDMGVMLPDVRTAAEQSDFVVL
                     ESNHDINMLKNGIYPYPLKQRILSNRGHLSNEACAKELVNLVEKGTLRLMLGHLSEENN
                     TVPLAMSTSVDLLTSNGMKYKSDYSLDVAPSVSTTKTIIF"
     CDS             20464..20949
                     /locus_tag="ctg12_59"
                     /transl_table=11
                     /translation="MIKINIICIGKIKEKYFTDAIAEYAKRLTAFCKFNIIELSEERIK
                     SNIPNQSQIDEVIFSEGKRIMQKISPSDYVVAMCIEGKPMSSEELSTLIDNASVSGKST
                     VDFVIGGSYGLDELVKKRADVRLSMSRMTFPHQMARMILSEQIYRAFEISSNGKYHK"
     CDS             20964..22706
                     /locus_tag="ctg12_60"
                     /transl_table=11
                     /translation="MALDGIFLRHIKTEIEKEALGARVSQIYQPNREKLVFGLRTFSGN
                     KKLLLSARANSPRVNFCSSTPENPAQPPMFCMLLRKRIGGGKLVGLRQNGCDRVLMLDF
                     ECVNELGDTVMITVVCEIMGMYSNIIIVDSNGVIIDSLKRVDLTMSSKRLVLPNIKYEL
                     PESQNKLNLLECTALDVCTAVKNLDTEMPLNKALLRTIEGVSPIVCREIEYKVMEGATN
                     KIKGVLFDRLAVEIENLKSVCSDCSGKPVVIYREDGKPMDFCFMNVEQYGDFAKVESKE
                     SFSDLLDGFYEARDSRDRMRVKSQSLTKLLNNTLERLARKIAKQQSELERCADREHLRI
                     CGDLLQANIYRIERGAEYVDVENFYDENNAILRIKLNPAISPSANAQKYYKDYRKAKNA
                     EIMLKEQLEKGREELDYIDSVLDTVDRAENEKDLAQIREELTEQGYLKVQKGKKPRQTT
                     LPPLEFESSDGFKILVGRNNRQNDKLTLKTASKNDMWLHTKDIHGSHVIVVSDGKEISD
                     TAICEAAQLAAYHSKARNSSQVPVDYTLVRYVSKPNGSKPGMVIYVNNKTLYVKPSQFK
                     IKTE"
     CDS             22712..23212
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_61"
                     /sec_met_domain="Isochorismatase (E-value: 2.9e-29,
                     bitscore: 94.6, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTLIVIDMQNDFIDGSLGTAEAVKIVPNVRKKIEEYRSNGDEI
                     IFTRDTHGEDYLSTPEGKKLPVVHCVKNTHGWQIADGLDVPDAIHIDKPSFGYTHWDKF
                     CFEKIELAGLCTDICVVSNALILNALFPYAEISVDSACCAGVTPETHNSALATMKMCQI
                     DVV"
ORIGIN
        1 tatgacgctt gcctgcggaa aataccgctt taacaagctc gaattcggtg acatcgacgg
       61 cttgccgaga ttactcgaca tcggtcagtg caacgatgtt tactccgcaa tctgtattgc
      121 cgtagcactt gccgatgcgt ttgatacaga tgtaaacggc ttgccgttgt cgctgattgt
      181 ttcgtggtat gagcaaaagg cggttgcaga tttgctggca cttttaagcc tcggaataaa
      241 gaatatctac ctcggcccga cactccctgc atttttaagc ccgaatgtgt tgcagtattt
      301 gtcagaaaca ttcggcttgc gtccaatcag caacgcagaa gatgacctga aaacctgcct
      361 taaacagaat gtttgatgat atactgtagc ggcgaacctc gttcgccact acaaattgtt
      421 tccaacaatt gaccgtaaaa aatggctaac ggtttgtcat acaacaaaaa acggagcaga
      481 ctgaattgtg tctgctccgc tttttgaaag agatatttat gaaaatacta ctgagttaat
      541 ttttcttccg attttttatt tttcatttcc gattcaagtt cttcttcaat ttgttttatt
      601 tcatcgtcac gccgtttgcc ctttgtaaag taggagaacg gggcagaaat caggattgct
      661 ccgtagtatg taatgaatct ccacataagg attgccggct tgattttgct tattgcaccg
      721 attttgaaga acgaaccgaa gtacattgtg aatgcaagct ccgcaccgcc cgatgcaccg
      781 gggagtggga taaggtttgc tgtaaacagt acgaatgact gaatgcagat tgaatcgtaa
      841 aatgacagtg tcggctgacc tgccgctctt gcaatcggag ccattccaaa tgaaatatag
      901 atgagatacg ggattgaaag aattaaaagc acctgtataa atacaagcac ataaatcaca
      961 acaagccgtt ttacgcttga aaaaagctgt ttgtttgtgt cgtgaaacat atcaacttct
     1021 ttttgaagtc tttcaacctt cttttcggga tttttaatga acttgaactt tttcataatc
     1081 ttataaataa gattgatgag cttgtttgta accttacggc tgaacgaaac aagcaggaac
     1141 aaagccgtca ttgcaagctg aacggtaaat ccgaaagcga tgaaaagcgt tgaccagatg
     1201 tttgtaaaag catcgctgaa atagttgaac cttgtgataa cggcaataac gctgacagcg
     1261 gtcattacta tctgatacac aatgaacttt tgcgtcatac aagccgaacc gaaacctacg
     1321 cttatgttct tttttgacat aaggtaaagc tgcataggct gtccgcctgt acttgacggt
     1381 gtaatcgcac tgaagaatac tccgacaaat gcgaccttca aagcctcaat aaagctgaaa
     1441 tccttatatt ttgaccgcac atatatcagc gtgacaacag cgtcaacaag gatgttcaaa
     1501 tcataaatca gcaaagccgc aaggataatc agcatattgc agccgtcagg ctttttgagc
     1561 aagtcgatca gaccgtcctc cgaaacaaag aagtagatga tcagataaat cgagattgcc
     1621 acaacagcga gattaaatat cagctttcca ctgattctga attttttctt ttccaaataa
     1681 atcttctcct gtgtgttaaa agttgttatt caattgtagc gggcatcaaa tgtcacatct
     1741 gtggcatttg cgcagaatta tatatcctaa tcatactttt ttttaataag aaaatcaaca
     1801 acaaatttgt aataaattgc cgcatgggaa aataaattta taaatccacg cttttttatt
     1861 ttatcgaatg tacttatttt agcatttgtt cattacacat aaagaattta aaacttgcac
     1921 ccaaacttta gctgtgataa aataatacgg taatatgtgc ggaggtgttc ttgtggatac
     1981 tatgagtgtg aacggaaaag cttttgccgt cattaagctt ctcggaaaag gcaagggcgg
     2041 ttattcctac cttgtgtcag acggagaaca caattatgtt ttaaagcaga ttcaccacga
     2101 gccgtgttca tactatacct tcggtaacaa aattcaaagt gagcttaacg attacgaacg
     2161 gctgaaaaat gccgggctaa gactgccgaa gcttattgac tgcgatgtgg aaaacgagag
     2221 gattcttaaa gattacattg acggcaaaac cgcatatgaa cttgttctgc agaatgagat
     2281 gaaacccgaa tacattgagc aggttcgtga aatgtgcaga ctgttgaatc caaaaggaat
     2341 taacatagat tatttcccga caaatttcat tttaaacaac ggacttttgt ggtacatcga
     2401 ctacgaatgt aacgattata tggaggagtg gaattttgaa aactggggaa taaagtattg
     2461 gagcaaaacg aaggaatttt gtgaatacca cgaaaacaat aaataacgga gtgaacttat
     2521 ggactttttc agtacaaatc tttttaactg gtacggactt gcttttgcaa ttgctttgct
     2581 tgtacccgac atcgtctata taaaaagcaa cagaatagac agaacaattt ttgataacag
     2641 ggctatgctt tacatagaaa gaatcggaaa atattgcagt attttcctta tgggaattaa
     2701 cattggcgtg cttgagggcg gttttacaaa gccgattatg gaaacctttt ggataatctc
     2761 aacctgtgtt ctgacggtcg ttgcacttat tttgtggttt ttatgcttta acagattttc
     2821 aaaattatgg gcatatcttc ttacagccgt aaccgcagta atttttatga tgagcggact
     2881 tttgcaggtt aaaacgcttt tgctcacggc aggcgtggtg taccttatcg gacagcttta
     2941 tgttacaaac aagtatgtaa aatcaaaaat gcaataattg tgtaaaatat tgtaaaaaga
     3001 tattgcaata ttgtttgttt ggtactataa tgacctttgg ctgacaaata cttgtttttt
     3061 gactggaggt gaaaagatga atgttattat gcttttaaag cataaagatt ctttaaaata
     3121 tatttatgag gacaataccc taagacaggg acttgaaaaa atgcgtgctc acagctacac
     3181 cgctatccct gttataaccc gtgacggaaa atatgtcggc acggtgagcg agggtgactt
     3241 cttgtggcat ataattgaca aaaagacttc gggcgatatt gaagaacagg aagaatttcg
     3301 tatccgtgac atactccgtc ccgactttaa tccggcagtt aaaatttcgg taggtatgga
     3361 cgagcttctt gcacgggcaa tgaatcagaa ctttatcccc gtaaccgatg acctcggtac
     3421 ttttatcggt atcgtaaccc gtcaggatat catcagatat tttgtcaata aataagatac
     3481 ataaaacaag gcggatgctg aaaattgcat ccgccgtttt agttatggca gaaactgaat
     3541 ttttaatata cagaaatcta catatcaact tcagattgat gtattacaat caaagtacgg
     3601 tgaggaaaat gtacaacatt cttttggttg aggacgataa aaatattcgt gaaatgcttg
     3661 tcgaatattt ttcaaaaaga gataaagata aatttaatat cacccttgcg gaaaacggct
     3721 taaagggact tgataaggca tatgagaaca gctatgacct tttgctcctt gatgtaatgc
     3781 tccccgaaat ggacggtttt acgctttgca aagaaatccg cagatacagc gatgtgccga
     3841 ttatgttcat cacggcaaga acaagcgagg ctgatatgct caacggctac gctctcggct
     3901 gtgacgatta cattgtgaag ccgattgctc tgcccgtatt ttatgaaaag gtgaaagccc
     3961 tcatcaagcg ttcaaaagga cttgtgcggc acaatttgct tacggtgggg aatgtttcgc
     4021 tcaatccgaa caacggtgtt gttgtgtccg acggtgaaga agtaaccctt accgcaaagg
     4081 aatatgctat tcttaaaatt ctgttagaga ataaaaacag cgttgtgtcc cgtgaaaaaa
     4141 tcatcacagc cgtttggcac tatgacacga tgattgatga aagagtgctt gacacgcata
     4201 tcaaaaatat ccgaaaagca ttgggcgaaa atgcgtctgt tttgaaaacg gtaatacggc
     4261 gagggtataa ggcggaggat aaaaaatgaa atcaagatat atcaaacgtc gaaaaaagtt
     4321 tcattacatt ataatttccg taacaataat tgtgtgtctg ctgggaacgg tttttacctc
     4381 tcttgcaata ctgaacagct ccaaagactt gttagttgcc aatgccgaaa atgagcttaa
     4441 aatgaagatg attgatctag agcataacct tggcataaat ttaacagatt ctcaagatga
     4501 taaggtgaat ggagcttatc catacaatga caaagtagga ttgctgaacg aaaatgttga
     4561 taaaagcaat acatactatc aggttactga taagaaaaat ttgacgataa ctacggataa
     4621 tgttcttacg gtgtattata tatcgagtaa cagaaattat ataagttttg atgtgattaa
     4681 aaatttgctc agtgataatg agtataaaga gatttgcgga tatctcaaca ctccgactga
     4741 taatgacgga aattactatg tcttgatttg caaaaagttt tatgaaagcg aaaaatacgg
     4801 ctatgtccct tgtcagcttg aggttgtaaa gaccaacaaa gtgaatgatt ggtatgttca
     4861 ggatgaagtt gttaaaacat atagctttga ccttagcaaa tatgattatt tgaccataga
     4921 agaattagag gctactccgt ttgaaaatga cgaaatgcac cgtaatataa ttgataaaga
     4981 tttttttctt ggaaaggaca aacctaaata ttctcaaaag aatgtagaac aaattcttaa
     5041 agataacgcc ttatcttata ttgatattta cgaatcacct gctgttgtaa atgacgggat
     5101 ttttaaatgt tatttgttga gcagtgatta ctattacaac aaagaaaatc gcttgataag
     5161 tgatctcgat gatagtgact atgtatataa agttgtacag gggtcttatt tgattgtttc
     5221 tttaaaagaa atagatttac tcaatgattg cctatggaag tttataacgg tatttgctgt
     5281 tgcgtttacg ataatggcgg tggtgattac ggttgaaatt ttctcgtgga aagattttaa
     5341 aaggcgaacc gcacaggagg aaacccgtct tgaaatgaca aatgcaattg cgcacaatct
     5401 caaaacccca ttgtttgtca taggcggttt tgcggaaaat cttaaaaatg aggaagatac
     5461 cgaaaagaaa cttcacaaca tagaaatcat tcagcaacag accgaggaaa tggacattct
     5521 tattcacaga atgctcgatt tgtcacgatt cgattcgccc gcattaaagc tgaattgcga
     5581 agtatttgac tttaaaccgt ttattgagaa aattcttgaa aattattatg ttcacacaga
     5641 acacgaaatt attttcattt acaactcaaa ggcaaaaata aaggctgact ctgccatgct
     5701 taaaacggtg cttgaaaatc ttattgacaa tgccgaaaaa tattccgatt acggttcgga
     5761 tatcacaatt aatgtttcgg atgatgtatt atcaatcagc aatcaatgct cgtcatttga
     5821 cagggaaaat ctctcaaaat tgtggcagcc ttatttcaga gccgcaaagg gagataataa
     5881 gagtggcagc ggaataggac tttcaatagt aaaatccgcc cttgaaatgc atggattcaa
     5941 atataaagcc gaatttgaaa acgggattat aacatttaag ttcagattta cttcactcga
     6001 ttgagttttt ctgcctaaaa aatcggaaca gccgtaaacc caatcacggc tgttccgatt
     6061 tttgttattt tgttatgtat aaaattctat ttttgtttat aatacatcag gcaatggcag
     6121 tatccctcaa attcgggatc ggcaattttt gccctgaaat cctcacacat acacagtgtt
     6181 gcagggcttc tgattaacat atacggacaa taaccgcccg tgcgtataag ctgtttgcga
     6241 acttctttta caatttcttt gtctggatta agcagaattt tcaatttaat caccatattt
     6301 gttgggtaga ttttatgccg attttcgggt attcggtaat cttttgattc cgcctacaat
     6361 tatatcagca atgacagaat tttacaatag aaaatttgca ataaatacaa atttatttga
     6421 ataattataa ttaaatctca aatgcaacaa tatactatat aaaaaaattc ataaaaaaca
     6481 gcaagtgaag aatttttgcg acaattattt gttgaaacag ttgatttttg caaaatagtg
     6541 tgctacaata gcgttgtgat tgtatataca tttatcatac aatgattttt agttttcagg
     6601 aggaaaattc tatgaaaaag gtaatgtcct ttgcaatcgt tctgatgctt gcattttcat
     6661 gcgtgttcac agcgtttgca cagacagacg acacagcgac acccgatgag gcaaaaaagg
     6721 taacagagct taaaattaca aagctccccg acaagcttac atacacagct gaggatgtga
     6781 ttgatcctga tattgattta tcaaaaatcg cagacgaaaa tgcaacagaa gaaagtctaa
     6841 tcaagtattt cagtcagttc aattttgaac tcaagcttga cctcacaggt attgaagttg
     6901 aggcagttta cagtgacggt acaaccgaaa aggttgatgc taaagactgc aaagctgagc
     6961 ttgctgatcc gtttaattac ggcgaagcaa ttaaggcatt gcttgaatat gagaaaaata
     7021 tgcctgattt tacagaagat atgaccgagg atgagtttga aaaaattgtt actgaattaa
     7081 actcaaagct ttacggtatg atttacagag agtatactgt aaatgtatca tatcaggatg
     7141 cacagacaag ctataagatt aaatttgaaa atattaacga tgtgcctcag cttgatgagc
     7201 gttacgaggt cgtttccgta aaagcacccg aaaaggtgaa ctacacaaag gctgatacag
     7261 atttcttcta tgaggctgat atgccgtatg acggaagccc cgaaagcaag gaatactacg
     7321 atgaaacata tttctatccc gaatttaaag gtcttgaagt tactgtaaag gataaaatta
     7381 caggcaaaac ttacacaaag acttttgacg gtacagagga agatattgta tatataagtc
     7441 ctgttgatgt tcgccccgat gacacaaaga caaatcttga agtttatgtt atgggtgatg
     7501 taaacgaatg gctcaatctt cccgaagatg aagagtattc aacagaggtt acaggtacat
     7561 tcaaggttaa ttactatgca aacggagttc cttcaaaggg caattcttca acaaatgata
     7621 cagcaactaa ggacacgccg agcaattcac agaacaacag cggtgcagtt cagacaggac
     7681 agaacagcgt tgcaatattc cttgcagctg caatgcttgc aggctgcggt gtaatttttg
     7741 caaaacgcag aactcgtttt gaataatatt aaataacatt attcagaaat aaatttataa
     7801 aaatgaccgc tttcactttt gtgagcggtc attttatttt gcgttttgtt taaaatgttc
     7861 caaaagttaa tcaagacata ttgctttttt aattatgaaa tgttacaatt aacttgcata
     7921 aaaaaataaa cgaattattt tataatgcgt agaatttgaa caaagtgagg gatagatatg
     7981 aaaaagtttt tacctatagc tatggcggcg gtaatgtcga tgtctgcggt tgcggtttcg
     8041 gcagtttctg caaatgcggt tgaaccgctt aacacacccg tgcagtatgc acaggttgca
     8101 agggcaagct ttgcaactcc gaaaatttca aaggctgaaa gcgtttacgg cggtgtaaag
     8161 cttacatgga acaaagtgaa cggtgcggct aaatacagag tttactacaa gggcagaaaa
     8221 ggctggacac gaatggttga tacaacttca acctcatata tcgacaagga tgtttcatcg
     8281 ggcaggaatt acacctatac tgtaagatgt atttctgctg acggaaagag ctttacaagc
     8341 ggttatgatt caaaggggac aactgtaaaa tatgttgctg ctcccgaaat ttcaaagctt
     8401 gaaaatgtaa acggcggtgt gaaaatctct tggggcaaag taagcggtgc gactaaatac
     8461 agagtctatt acaaaggcag taaaggctgg acaaaaatgg ttgatacaac ttcaacctca
     8521 tataccgata aggatgtttc atccggcaga aattacactt atactgtaag atgtattaca
     8581 tcagacgcaa agaaatttac aagcggttat aacccgacag gcaagtcggt aaagtatgta
     8641 gccacaccga aaatttcaaa acttgaggtc acatatgacg gagtaaagct gacatggaac
     8701 aaggttgcag gtgcagaaaa ataccgtgtg tactacaagg acagaaacgg ttggacaaag
     8761 cttggctaca caacgggtac aacaatgctt gatatgaatg ttgtttcaaa ggaatttgat
     8821 ttaagcgttg atgatattta ttacacggtt cgttgtatca gcaaggatgc caagagtttt
     8881 acaagcggct acgattcaaa gggtaagccc attggcgatc atcaggattg tcccgaaatt
     8941 tacagcattg gtgcagtaaa aaacggtgtt gaaatgcatt ggacgggaga tgcgccaaag
     9001 ttccgtgttt atattaaaga aaacggttct tggaagaaga tagcagaaac ttatgacaac
     9061 cattatgttc acaagggtgc aaagtccggc agtaacactt atacggtaag aggtgtttca
     9121 aaagacggta aaaagtttac tacgatgttt aacccaaccg gtgtaacata cagatataag
     9181 acatccgata aaacaaggga cgcttttatc aattatatga tgaatcatac tgatgaatgg
     9241 atgccaagtt tgggaagtaa tcacaatttg tcaggtatta tgtttttgga tttcgacttt
     9301 gacggagttc cggaacttgt tgcacaaaag tctgattcca aagagtatgg tttccattcc
     9361 gttgtttaca aatttgaaga cggtaagtta aaaagagtgg gaaatgttaa cgacggtttt
     9421 tcgatatact ataataaaac tgccaaaaag tatgaggttc acgacctaaa gatatcttta
     9481 aatgtagatg acggttacta ttggtcgggt aattcaataa tcacatacga cggagagaat
     9541 ctttttgcaa atatgtattc gtcaagaggc gtagtcgaag aatcaaataa tatttattat
     9601 agatattttg acggtaatga caaaaatatt tcacgggcaa aatataacga aattaacctt
     9661 aaacagttta ataattgcgt aaatgcacat atgtttaccg aatttattgc gacaggttat
     9721 ggtgatacca gcgcatgggg tgagaaaact accgctgaga ataagcagtc tttgcttgac
     9781 gcttataatt ctttctccta tgagaagtat tgattattta aaaattgata agttttaact
     9841 gcaaaagggt tcagctgtaa aaagctgaac ccttttattg cacaacaaaa aacggttcag
     9901 ccaaattgac tgaaccgtta attcgtacta tgtaatgctc gggtgacaga agtttgaata
     9961 tatcaaactg tcttcacgaa ctgtgtgcga gacactcgca ttagttgttg atgagcttat
    10021 cttcgtcaga ccagctgtag agctttctaa cttccttacc gaatacttcg gcaggagctt
    10081 cggcagcgat ctttctcata gccttgaagt gaacctgtga accggcatcg ctcatgtcaa
    10141 ggaggaagtc cttagcaaat gtaccgtcct gaatgtcaga aagaaccttt ctcatagcct
    10201 tcttagtatc ctctgtgatg atctttggac ctgtgatgta gtcaccgtac tcagctgtgt
    10261 tagagattga atatctcatg cctgcaaaac ctgactgata gataaggtca acgatgagct
    10321 tcatctcatg gatacactca aagtaagcgt ttcttgggtc gtaaccggca tcgcaaagtg
    10381 tttcaaaacc tgcctgcata agtgcgcaaa caccgccgca aagaacagcc tgttcaccga
    10441 agaggtctgt ttctgtttct gttctgaatg ttgtttcaag aacacctgct cttgcaccgc
    10501 cgataccgag tgcatatgca agtgcgagat ccttagcctg acctgtagca tcctgctcaa
    10561 cagcaacgag gcaaggtaca cccttaccaa cctgatactc tgaacgaact gtgtgacccg
    10621 gtcccttagg agctaccatt gtaacatcaa catcctttgg aggcttgatg caaccgaagt
    10681 gaatgttaaa gccgtgagcg aacataagca tattgcctgc ttcgaggttt ggctcgatgt
    10741 cgttcttgta aagagctgcc tgcttttcat cgttgataag aatcatgatg atgtcagcct
    10801 gctttgcagc ctctgccgat gtatatacct taaagccctg tgcttcagcc tttgcccagc
    10861 tcttgctgcc tttgtaaaga ccgacgatta catcgcaacc tgaatccctg aggttgagag
    10921 cgtgtgcatg accctggctg ccgtaaccga taatagcaat tttcttaccc ttgagaaggt
    10981 caaggttgca atctgactga tagtagattg gtgctgtcat gttttttgtg tagtctttca
    11041 tattaaagtc ctccttaccg caaacgcggc atataaatta aaatatatgc taactgtaag
    11101 attaaacgga aaccgaagct gtgcctctgt caatggcaac agtacctgtt cttacaatct
    11161 cacggatacc ataaggcttg agtaagtcaa caagcgtgtt gacgcggctt gcacattcgc
    11221 agtactcaac ggtaactgac gaaggggata catcaacgat tttcgcctgc ataatttcaa
    11281 ccgttttgac aatttcggct ctttttgagg cggcgcagtg aaccttgatt aaaacaagct
    11341 cacggctgat aaattcgccc tcgttaagcc tttttacctt gatgacggga atgagcttgt
    11401 ttagctgttt ttcaagctgt tcaacaatgt actcgtcacc gtttgcaacg attgtgattc
    11461 gggaaaccga cggttcctga gtaacaccta ctgcaagtga gtcgatgtta aaacctcggc
    11521 gagagaaaag tcccgaaatc tttgaaagaa cgcccgcctg attttcaaca agtattgata
    11581 atgtatactg cattttatca cctcattaaa ttgacggagt gtcggggtga acatcgcaaa
    11641 caagaatgaa cggtttttcc gaatcaacaa tacccttgat gatgttttcg gcttcctcgt
    11701 ttgaatgagc ctctgcatgg tcaatgccgt aagcatcggc aatcttcaag aagtcgggat
    11761 caccgttgag aattgttgcg gagtgtctgc caccgtagtg tttgtcctga agttcacgaa
    11821 ccattccgag tcgtgcgttt ttcataatga tgattttaat tccgagctga ttgcctgcaa
    11881 tagtcgcaag ctcattaagc cccatctgaa aactgccgtc accgcagatt acaataacat
    11941 cacggtcggg tcttgcaaac tttgcaccga ttgcggcagg aattgagtaa cccattgtac
    12001 ccataccgcc tgttgtgagg aatctgccct cacgaatacg gaagttgttt gcacaccaga
    12061 tttgattttg tcctacatcg gcaacgagaa ttgcctttga gcggaacatt gcactgagat
    12121 gaccgacaag tgttctcggc tcaacaaagc cgtcaaaaac gggaggctca cggtaaaggt
    12181 cttttttcca gttctttacg gtttcgctcc acattgttgt aaccttgtaa tcgccgatgc
    12241 tgtcaagcag catattgatg acatttttca tatcgcctac aatcggaatt tctgttttaa
    12301 cattcttacc gatttcagca gggtcaatgt caatgtgaat tacctttgtg ttttcactca
    12361 tctggtcggg agccgcaaca gctctgtcac cgagtcttgc accgcatacg attacaaggt
    12421 cggcttcgtg gagagcacgg ttggcaacag ccttgccgtg agtgccgagc attccgagat
    12481 aaagctcatg ctcgctgggc ataacaccga tgcccatcat agttgaaata acggggatac
    12541 ccgtagtttc tgcaaatttt tgaagtttaa gcttgatacc cgaactcagc acgccgccgc
    12601 ctgatacgat aacaggacgc ttgcttgcgt tgatggcctc aacagccttt ttaacctgaa
    12661 ttgcgtgtcc cttagtgttc ggcttgtaac cgataatgtt tacgctttcg ggatattcaa
    12721 aactttcaat ttcattttcc tgaatatcaa cgggaatgtc gataagtaca ggaccgggtc
    12781 tgccggttga ggcaatatgg aaagcctctt tgaaaactct cggaaggtct tctgttttgc
    12841 tgacgagata actgtgcttt acaaacggtt cacaagctcc cgtgatgtca gcttcctgaa
    12901 agacatctct gccgagaagg tcggaacgaa cctgacctgt aatggcaaca atcggaatag
    12961 agtccgtata ggcggttgca atacctgtga tgaggttggt tgcaccggga ccggaagttg
    13021 ccacgcaaac accgggacga ttactgcatc ttgcatagcc gcttgccgca tgagcagcgt
    13081 tctgttcctg acgaacaaga atgtgggtaa tgctcgaatc gtaaatttta tcgtaaaatg
    13141 ggcagatagc cgcaccggga taaccaaaga ctatgtcaac gccctcggct tccaaacatt
    13201 ttaccataat ttcagcaccg ctgatcatta tgttttgtcc ctcctatcct ttttattgtg
    13261 agcaaaaggt gttttgtaac attaaatata cccttttact ttaccgctaa ttatacaata
    13321 aataccttaa aaagtaaaga gcagtattgc ccataaatta aattttttgc aggattttga
    13381 cagataattt gcaaaatgaa ttttaattga tttttaccgc ctgtttactg aaaatttaag
    13441 tcgcttaatt ttgtaaagta tattcttgca ttaaggtcgc ttttttcatc tgcattatca
    13501 ggggacatca ttatcatcaa attatctttt cctattcgtg atatactgcc tatagtgtac
    13561 cctttttctt caatattgaa ttttgtttct ttcattgttt tgttggttgt atcaaaaaga
    13621 tatatgtagt tatcttctga acttgattcc gccctcttat acaataaatt tgtatcactg
    13681 tcatcttcag atgcggatac tattgaaaaa gtatcatcta catcttctga tatgtcggat
    13741 tttttcagtt tatcgctgtc tatatatcct atacatcttg ttatactgaa attttgatag
    13801 aatagataat tgtttttaaa atcaaattcc tgtacgccct gaattaactc gtttgaatca
    13861 tctgaaatgt tggaaatatc atagcttttt tgaaaattca tattatagtc ataagtttct
    13921 attttcaaag aagcttcgtt ctgtgaaatg caatccaaaa ccaaaagaga gattgttttt
    13981 gtacttttgt caattgaaac ttttcttata gtttccccga tactgttttt atcatcaaac
    14041 tctaaatatt ttaattgctt gaatttttga gtttcggtat catacagttc caaagaagta
    14101 ccgttgttta gcacttttgt gattatgaca agattgtctg ctcctgtaac agtgtcatat
    14161 ggaaatccgc ctttgtcaga aaatacagtt gtcattttgt ttttattaag gtcgatatca
    14221 ataaattcga gagttctgtt ttcttcgtct gtaatgtcac ctgtgcttgc cgtaaaacaa
    14281 aggtgattat ttacataagc tttatcgtga atttgcatag accagtcttt tattgagccg
    14341 agttttacac tgcttttttt atctaaataa tatctgtagt attccatttc atttggagag
    14401 tctttattga tttttgaata tatgaagccg ttatcaattt gtttaaataa gccgtaaaga
    14461 tttaaagtat ccaccttttt gccgttattg taaatttcta agttatgatt taattctgtt
    14521 gtttcaatat ctgaatcaag agataaatca tctgtatccg ttacggttgt ttgttcagtg
    14581 gaattattgc ttgatgaaga agtgttacat ccatataatg aaagtaaaaa taaagcggtt
    14641 actaataata aaaatatctt tttcaaatta atctctccga agtttattta tcagttacaa
    14701 gcgctgacaa aaatattata atttatataa ttataaaagt caatgatttt aaaatactat
    14761 aatataagat tatgtttaga aaaattttgg caaatgaaag caccgtgaaa cttgtgaaag
    14821 ctcacggtgc tttatcatga taaatgatat gatttgcaaa aaaatcaata tttctttttg
    14881 aggagtcttg cggcaatgag tacgcagact acgctgacgc ctgtgtcggc aataacggac
    14941 atccagattt gtgcaagacc gaatgcggcg agaatgatta caagagcctt gattgagagg
    15001 gcaaagatga tgttgccctt gacggtgttg ataacacttc ttgcaatttt aattgccttt
    15061 ggaagctgtt tgagtgtgcc tgatgcgaga actgcgtctg acgcttcaat agctgcctca
    15121 ctgccgaatc ccattgcgat accgcagtcg cttgccgaaa taacaggggc atcattgatg
    15181 ccgtcgccca caaagcaagc acccttggat tttgatttca agcccttgaa aagttcaagc
    15241 ttttgagcag ggagaagttc tgcgtgacat tcggaaagtc cgagttcatt tttaacattt
    15301 tcggcaggct gttgtctgtc gcctgtgagc attaccgtgt tcttgacacc gagcgcttta
    15361 agctgtgaga taacctcttt tgcctcaggt cttactgtat cgctgacatt gagcgaaccg
    15421 ataagctgac cgtcataaat tacgaaaaca gaatcgtctt tgtttgcaat cttcttctgc
    15481 tcgtccgaaa gaatctttga accgccgcac tgaatagttt tgccgttata aactgcgctt
    15541 gttccgtgac cggcactttc gctgtagtcg gaaagctcgg gaagttcaag accgtttgcc
    15601 ttttctctga ttgcggaggc aatcggatga gcggaatatt tttcgcttgc agcggcaaga
    15661 gcaagaactt cgtcagcact gtatgaaccg acagtattaa ccttgtttac gctgagcttg
    15721 ccgcttgtga gcgttcctgt tttatcgaat acgaatgtat ctgcttttgc aagagcctca
    15781 atatattttc cgcccttgat gagtacaccg acttcggatg ccgcaccgat acccgaatag
    15841 taggagagag gtacggaaat aacaatagca cacggacatg acgctacaag acaaacaagc
    15901 gcacggtata gccattcgct gaatgctccg agtccgcaaa gcggaggaat tactgcgatt
    15961 gcagctgcaa tgagtacaac aaccggtgtg taaacagagg caaatcttga aataagcttt
    16021 tcgctgttgc ccttttgagc ggcggcatct tcaacaagct gaagaattct tgttgcggta
    16081 ctgtcgccga aatgttttgt ggttttgacg gtaataaggt tactgccgtt gattgcgccg
    16141 ctgagtacct cactgccctc gcctgcatca acaggaaggc tttcgcctgt gagagccgat
    16201 gtgtcgagag tcgttttacc tttaataata atgccgtcaa gcggaactct ttcgtatggt
    16261 ttgacttcaa tgatacttcc gatttcaacg ctttcggcag gaacaatctg ttccgcaccg
    16321 tcaacaataa ttgttgctgt atcgggacga atgtttgcaa gcttttcaat gtcacggcgg
    16381 gacgcgtcaa ctgctcgatc ctcaaaaatt tcaccgatag aaaagaggat tgttaccatt
    16441 gccgcctcaa caaaatctcc aagacagaat gccgtaatta ccgcaacagc cataagcgtt
    16501 gtttcgtcaa ttctcagctt tagaatgttt tttgcaccct tgataaatac cttgtaaccc
    16561 gaaagaagtg ttgcaacaaa acacgctgcg agtacaacat aatgaacagc cgtaacaccg
    16621 tcaagtgtaa ggtggagaat ttcggacact acagcaagta caattgaaat tgcaaggaag
    16681 attgtgtcac ggttgatttt ctttttcgtg atttcgggtt ctgcctttgt tgtgatatca
    16741 tttttcggag ttttgtcaac aacagttaca ccgtcctcaa tgctgtcgca gatcgcctga
    16801 atttcggaaa caggattctg cttttcgctt ttgaaattga gaagttttgt cgcaaaattg
    16861 aagcttacat cttcaaagcc gtttgtttct gcaattttag cctcaatctt gcctgcacaa
    16921 tgagcgcagt tgagattgtc taaagtgtag gtgtattttt tgagattggt tttcggagtt
    16981 ttgtcaacaa cagttacacc gtcctcaatg ctgtcgcaga ttgcctgaat ttcggaaaca
    17041 ggattctgcc tttcgctttt gaagttgaga agttttgtcg caaaattaaa gctcacatcc
    17101 tcaaagccgt ctgtttctgc aattttagcc tcaatcttgc ctgcgcaatg agcgcaattg
    17161 agattgtcaa gctgatattt atacctcata tgttccccct tattcaagaa catggtcaag
    17221 tcccatttcg atgattcgtt tcacatggtc atcgtcaagg ctgtaataaa tctgctttcc
    17281 ttcacggcga acacgcacca gcttgttctg ccttaacaca cgcagttggt gggaaattgt
    17341 gctttgctcc atgctgagag cttcagcaat gttgagcacc gacatttcat tttccgaaat
    17401 ggtgtacata atgcgaagtc gtgttgaatc accgaaaacc ttaaaaaggt ctgcaagctc
    17461 aaacagcaca tcaatgtcgg gcatttcggg agtggttgtt ttttctttgt tttccatagg
    17521 cgtccccttt aattttccgt cagattaaaa gttatacttg aacatatgaa gatatgctca
    17581 tatgttaatt ataatatagc attcccattt aaaaaagtca atagacacac acgaaaaagt
    17641 gtaataattt tcaagttttt ttaccctaat atttcgcttg tttattgtgt tcgtttggag
    17701 agtatatata atatagtata ggaagtgaag cttaaaataa aagggagaaa aggaagaatt
    17761 aaaggtgcaa agttactccg aagcggcaga atgatatttt tctgtattca atttgaattg
    17821 taaaatgctc agactcctga tgataacacg aaaataacac ttgtttcaat ttgtaacaat
    17881 cttacaaaaa aagccgttga gtttttactt ctttttaatg aaaatcaatt caaaaaatga
    17941 cgcttggtta taataaaaac aaaaacagca agaaatcaat aaattgagta caacctgccc
    18001 aaaaatagat tacagtttta ttattccgtt gactttacta cagttttgta gtatcatttt
    18061 ctataagaga attgataggt tacatctgcg taatcgagca ggtttatttt taataaaatg
    18121 taacaaatta gttcctgctg cgaattttaa attcgtgtta tttttgactt ttacttattt
    18181 gatatatatt tcagatattt ttttaatatc ttttgcacat aattggggtg taacaattgg
    18241 agaagtttgt agttaccggc ggaaagccat tatcaggtga agtgacaatc agcggtgcga
    18301 aaaatgcagc cgttgcaatt attccggcag ttattctttg tgatgaaccc tgccagattg
    18361 aaaatattcc taacatcagc gatgtatcgc tcatcagcag gattcttcag cagatgggtg
    18421 ctaatgtaag gcgaatcaac cgttcgtctt tatatattga tcctacaaaa atccgcacat
    18481 gcaatgcggt tacagacctt gtaagaggta tgagagcatc atactatctt ctcggcgcac
    18541 ttttgggcaa gtacggcagg gctaaggtgg ctcttccggg cggctgtaac tttggcgtgc
    18601 gtccgattga ccagcatctc aagggctttg aggctctcgg tgcggcaact cagcttgttg
    18661 acggtgcgat tatagaggca gaatgcgaca accttgtcgg tacacatgtg taccttgatg
    18721 ttgtgtccgt tggtgcaaca atgaacatta tgcttgccgc atcaaaggca aagggtcaga
    18781 ctattattga aaatgccgca agagaaccgc atattgttga ccttgcgaac tttcttaatt
    18841 caatgggtgc ggatgtcaga ggtgcaggta ctgatgttat caaaatccgt ggcgttgagt
    18901 atcttcacgg cgttacctat tcgattattc ccgaccagat tgaggcagga acatatatgt
    18961 gtgccgccgc cgcaacaaga ggatgtatta cggtaaagaa cattacaccg aagcaccttg
    19021 aatcaatcag cgcaaagctg cgtgaaatgg gtgttaagat tacggaatat gatgaggctc
    19081 tcaaggttga cgcgtcatct gctccgctaa agcgctgtaa catcaagact atgcctcatc
    19141 ccggctttcc gacagactgt cagccgcagt ttgccgcatt gcttatgagt gttcccggaa
    19201 caagtatcat caacgagaat gtctgggata accgctatca gtatgtcagc gagcttatca
    19261 gaatgggcgc gcagatttcc gttgagggca gacttgcaat cattgagggc ggaactccgc
    19321 tcactgcggc tcccgttaag gcaaccgacc ttcgtgcagg tgcggctatg attattgccg
    19381 ctcttgaaat taacggcaca accgagattt cgaacataca gtttattgaa cgcggttatg
    19441 aggatgttgt tgaaaagttc agaggacttg gtgcagacat taaaaaggtg tattttacag
    19501 gagacaacga gcaggagctc ggtgcctgat taaaacttaa ttagaaatca aagccgtttt
    19561 ctttgtgaga acggcttttt tgtgagataa aatttacaaa tcataaaatt tgtgttatca
    19621 tatttggcag actaatgata aggattgatt gttttggcaa gagcagtacc gctgttcagc
    19681 ggaagtaagg gcaacagtta ttacataggt tcggcaaccg agggcgtttt gattgacgca
    19741 ggccgttcat gtaagcagat tgaaaacgct atgcttgcaa acggacttga tatgagcagt
    19801 atcggggcag tttttataac tcacgaacac acagaccatt gcagtgcctt gcgtgtgctt
    19861 gcaaagcgtt acggctttaa ggtgtattca agtcttggta cgctcaatgc tttgagggca
    19921 ggtaataagc ttgatccaaa cacggatgca gatgttataa ctgacgaggt tgtaatcggc
    19981 aatatgcgtg ttcagcgaat tgacacaccc cacgatgcgg cggaaagctg ctgttatcgt
    20041 gttactgctc ccgacggaaa atccgcactt atagcaaccg atatgggtgt tatgctgccc
    20101 gatgtcagaa ctgccgcaga gcagagcgac tttgttgtgc ttgagtcaaa tcacgatatc
    20161 aatatgctca aaaacggaat ttatccttat ccgctaaagc agagaatcct ttcaaacagg
    20221 ggacaccttt caaatgaggc gtgcgcaaag gagcttgtca accttgttga aaagggaaca
    20281 ttaagactta tgctcggtca cctcagcgaa gaaaataaca ctgttccgct tgcaatgtca
    20341 acatccgttg acctgctcac atcaaacgga atgaagtaca aaagcgatta ttcgcttgat
    20401 gttgcgccga gtgtcagcac aacaaaaact atcatctttt aaccttaaat aagcgagaaa
    20461 aatatgatta agattaacat aatctgcatc ggaaaaatca aggaaaaata ttttaccgac
    20521 gcaattgcag agtatgcaaa acgcttgacc gcattttgta aattcaacat tattgagctt
    20581 tcggaagaac gcataaagag caacataccg aaccaatcgc agattgatga ggttattttc
    20641 tctgagggaa aaagaatcat gcaaaaaatt tcgccttcag attatgttgt tgcaatgtgt
    20701 attgagggaa agcctatgtc gagcgaggag ctttcaactt tgattgacaa tgcgtccgta
    20761 agcggaaaaa gcaccgttga ttttgttatc ggcggcagct acggacttga cgaattggtt
    20821 aaaaaacggg cggatgtccg tctttcaatg agcagaatga cctttcctca ccaaatggca
    20881 agaatgattt taagcgaaca gatttaccgt gcgtttgaga tttcatcaaa cggtaaatat
    20941 cacaaataat ttacggagtt actatggcgc ttgacggaat ttttttaaga catattaaaa
    21001 ctgaaataga aaaagaggct ctcggtgcaa gggtgtcgca gatttatcag ccgaacagag
    21061 agaagcttgt gttcgggctg agaacatttt ccggcaacaa aaagctgttg ctttctgcac
    21121 gagcaaattc accgagagtg aacttttgtt cctcaacacc cgaaaatcct gcacaacctc
    21181 caatgttctg tatgcttttg cgaaaaagaa tcggcggcgg aaagcttgtg ggacttcgcc
    21241 agaacggttg cgaccgtgtt cttatgctcg atttcgagtg cgtgaacgaa ctcggcgata
    21301 ccgttatgat aactgttgta tgcgaaatta tgggtatgta cagcaacata attattgttg
    21361 attcaaacgg tgttatcatc gactcgctca agcgtgtaga tcttacaatg agcagtaaaa
    21421 gacttgtact gccaaatata aaatacgaac ttcccgaatc gcagaacaag ctgaatctgc
    21481 ttgaatgtac tgcacttgat gtgtgtacgg cggtaaaaaa tcttgacacg gaaatgccgc
    21541 ttaacaaggc actgttaagg acaattgagg gtgtttctcc aatcgtatgc cgtgagattg
    21601 aatacaaggt tatggagggc gcaaccaaca aaattaaggg tgtgcttttt gaccgactcg
    21661 cagttgaaat tgaaaatctg aaaagcgttt gcagcgattg ttcgggcaag cctgttgtga
    21721 tttatcgtga ggacggcaag cctatggact tctgctttat gaatgttgag cagtacggcg
    21781 attttgcaaa ggttgagagt aaggaaagct tctccgattt gcttgacgga ttctatgagg
    21841 ctcgtgacag tcgtgacaga atgagggtga aatcacaaag tcttacaaag cttttgaaca
    21901 atacccttga aaggcttgca cgaaagattg caaaacagca gagcgagctt gaacgctgtg
    21961 cagaccgtga gcatcttcgc atatgcggtg accttttaca ggcaaatatc tatcgcattg
    22021 agcgtggtgc ggagtatgtt gatgttgaaa acttttacga tgagaacaac gcaattttac
    22081 gcataaagct taatccggca atctcacctt cggcaaatgc tcagaagtat tacaaggatt
    22141 accgcaaggc taaaaatgcc gaaattatgc tcaaagaaca gcttgaaaag ggcagagaag
    22201 agcttgatta tatagactcc gttcttgata cggttgaccg tgcggagaat gaaaaagacc
    22261 ttgcacaaat tcgtgaggaa cttaccgagc agggctatct caaggttcaa aaaggcaaaa
    22321 agccccgtca gacaactttg ccgccgctcg aatttgaatc aagcgacggt tttaaaatcc
    22381 ttgtcggaag aaacaaccgc cagaacgata agctgacttt gaaaacagcg tcaaagaatg
    22441 atatgtggct gcacacaaag gacattcacg gttcgcatgt aattgttgtt tcggacggta
    22501 aagagatttc cgacacggca atctgtgagg cggcacagct tgcggcatat cacagcaagg
    22561 cgagaaacag tagtcaggtt cccgttgact acacactcgt tcgttatgta tcaaagccaa
    22621 acggttcaaa acccggtatg gtgatttatg tcaataacaa gacgctgtat gttaagccgt
    22681 cacagttcaa aataaaaacg gagtgatttg tatgaagaaa actttgattg taatagatat
    22741 gcagaacgat tttattgacg gcagtcttgg cactgccgag gctgtgaaaa ttgtgcctaa
    22801 tgtacgcaaa aagattgaag aataccgttc aaacggtgat gaaattattt ttacaaggga
    22861 tactcacggt gaagattacc taagcactcc cgagggcaaa aaactgcccg ttgtgcattg
    22921 cgtaaaaaat actcacggct ggcagattgc agacggactt gatgttcccg atgcaatcca
    22981 tattgacaag ccgtcattcg gctatactca ttgggataaa ttctgctttg aaaaaattga
    23041 gcttgcagga ctttgcaccg atatctgcgt tgtgtcaaat gcgttgattc taaacgcact
    23101 tttcccgtac gctgaaatca gcgttgattc ggcttgctgt gccggcgtaa cccccgaaac
    23161 ccataattcc gccctcgcaa caatgaaaat gtgccagatt gatgtggtat gataatggtt
    23221 tgaaaatt
//
