LOCUS       gnlProkkaIGCMKJBP_79   11385 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IGCMKJBP_79.
ACCESSION   gnlProkkaIGCMKJBP_79
VERSION     gnlProkkaIGCMKJBP_79
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 04:58:37
            Original ID  :: gnl|Prokka|IGCMKJBP_79
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 2769
            Orig. end    :: 14154
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11385
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:11383]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11383
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..11385
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11385
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             complement(750..2003)
                     /locus_tag="ctg79_3"
                     /transl_table=11
                     /translation="MFENIRLSFRGIWAHKMRSFLTMLGIIIGIAAIIAIVSTIKGTNE
                     QIKQNLVGAGENTVEISLYQGEWEYEMEYNGIPEGVPLVADEVVEQLKEIPHVENVSRY
                     LSRQDYNGVYHLNTGLSGGYVKGVDTAYFDTCNYIMKEGRGFTQQDFDQYHKVAILDED
                     SADALFQGEEAVGETIEIQQEPYVVVGIVTKAKKFEPVINSIDDYYTYAQDSAGSVYVP
                     ATTWPIIYQYDEPQNVVLRVESTDDMTSAGKAGADLLNGYLSVSDTTIQYKAKDLMEQA
                     QQIQELSSSTNTMLIWIAGISLIVGGIGVMNIMLVSVTERTQEIGLKKAIGARKSRILG
                     QFLTEAAVLTSLGGLIGVLVGIILAQVISYVTTTPVAISVPAAVGAVAFSMVIGIVFGV
                     FPSYKAANLNPIDALRHE"
     CDS             complement(2017..3693)
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 44.6; E-value:
                     1.5e-13)"
                     /gene_kind="transport"
                     /locus_tag="ctg79_4"
                     /transl_table=11
                     /translation="MKIKKVIAVIAGIAVTLSAAVGGVYGYKSYQDKKLIAEVQPVSNL
                     NWGYWGDTETSYGTVTNDSSQEIYLDDSRMIKEIYVEKGDEVQKGDPLLAYDTAELQIE
                     IERKKLDISTIENNIERQKYKYEMLKTQTPVKKDPPKLNEEQLAWYQHMDEENRLTETD
                     KNDSRIYNYLTAASIPYNVTTNAAGELVYPAGTAEEPYIYYVNQNAYAYGGFFNAIRPT
                     AEGGSGKHVRVIVCKKDADGKMVLDTDEATGRQTPVADDTVSPNTVELNGSDFPADYDE
                     SRMWYLFSGKEYIPTSLADEYMQAYEDFMADWEVPKGYTSEELYQEAAEIEEKLKTLDI
                     QRRQEQLALESMEKSATDGVVYAEVDGVVKTLGDPDEKPEQGQAFLVITGDDGLYVKGT
                     ISELLLDDVKMGTVVSANSWESGMTFDATITEISDYPVSGNSWGDGNPNVSYYEYTAYI
                     EDSSALRNGEAVDLSISTNQSDGGGIFIEKAYVRSEDGKAYCMIADENNRLKKQYVVTG
                     RTVYGSAVEIKSGLTEDDRIAFPYGKNAVEGAAVTDESSNY"
     CDS             complement(3690..4379)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 222.5; E-value:
                     9.6e-68)"
                     /gene_kind="transport"
                     /locus_tag="ctg79_5"
                     /transl_table=11
                     /translation="MILNLQNIYKDYQQEKLVVPVLKDVSLTVEEGEYVAIMGPSGSGK
                     TTLMNIIGCLDRPTSGTYELAGENVLKLKDRELSDLRLKSIGFVFQSFQLMPRESAVEN
                     VALPLSYAGVRKKERRGRATKALERVGLGDRVNFRPTQLSGGQKQRVAIARAMVNHPKI
                     LLADEPTGALDSKSGEQIMELFDSLNEEGVTIVMITHDPKIAAKAKRIVRIIDGEIYEG
                     EEDGAVS"
     CDS             complement(4376..5749)
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 80.4; E-value:
                     1.9e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg79_6"
                     /transl_table=11
                     /translation="MGKKSVGILIGVAAVAAVLGGTGYYFRDDIRQMIPIFDDGSSEDK
                     VYVEKVSRIMNQYAGVSNRYNGVVETQDSYEVNVDSSRTISEIKVEAGDEVEEGQTLVT
                     YDTSDLTMKIEQAKLELEGIQNEIDNYNKQIDTLTKEMEKVEESERYDYTTQIQNIQNS
                     IAQKQFDMESKKLEISKEQKQVSSSSVVSKVAGVVKEINEKGVDSNGNSAPFMTILQTG
                     EYRIKGSIDEQNVWMLSEGQEVVIRSRVDSTKTWSGTIGKIDTESPQQGNDNGYYSTSS
                     AGDTQSASKYPFYVDLDSVDGLILGQHVYIELDQGQEEVKEGLWLYGSYIVQDEDTPYV
                     WAANEKNRLEKRYIELGEYDADMDEYEIVSGLAEDDYIAWPMAGLYEGVTTVTDEAEVD
                     YSSPLYNQPADENLYDTEGVYDTELLYNVLDSVYDTELPDEMYDSMDVGEGTEAEVAE"
     CDS             complement(5928..7166)
                     /NRPS_PKS="Domain: Aminotran_1_2 (76-364). E-value: 3e-14.
                     Score: 44.8. Matches aSDomain:
                     nrpspksdomains_ctg79_7_Aminotran_1_2.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg79_7"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.4e-15, bitscore:
                     44.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTMEDIEAVDMEIAQAIKDEFDRQNSHIELIASENWVSPAVMSA
                     MGSVLTNKYAEGYPGKRYYGGCDCVDVVEELARERAKKLFGCDYVNVQPHSGAQANMAV
                     QFAVLKPGDTVMGMNLDHGGHLTHGSPVNFSGTYFHIVPYGVNDEGFIDYDKVMEIALE
                     CKPKMIIAGASAYARTIDFKKFREIADACGAVLMVDMAHIAGLVAAGLHPSPIPYADVV
                     TTTTHKTLRGPRGGMILCNQEAADKYNFNKAIFPGIQGGPLMHVIAAKAVCFKEALQPE
                     FKVYQQNIIDNAQALCKGLMNRGIKIVSGGTDNHLMLVDLTNFDQTGTAVEKLLDSVNI
                     TCNKNTIPNDPKSPFVTSGVRLGTPAVTSRGFNTGDMDQIAEAIAMMIKEGEPAADRAR
                     AIVAELTAKYPLK"
     aSDomain        complement(6075..6938)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg79_7_Aminotran_1_2.1"
                     /evalue="3.00E-14"
                     /label="ctg79_7_Aminotran_1_2.1"
                     /locus_tag="ctg79_7"
                     /protein_end="364"
                     /protein_start="76"
                     /score="44.8"
                     /tool="antismash"
                     /translation="ARERAKKLFGCDYVNVQPHSGAQANMAVQFAVLKPGDTVMGMNLD
                     HGGHLTHGSPVNFSGTYFHIVPYGVNDEGFIDYDKVMEIALECKPKMIIAGASAYARTI
                     DFKKFREIADACGAVLMVDMAHIAGLVAAGLHPSPIPYADVVTTTTHKTLRGPRGGMIL
                     CNQEAADKYNFNKAIFPGIQGGPLMHVIAAKAVCFKEALQPEFKVYQQNIIDNAQALCK
                     GLMNRGIKIVSGGTDNHLMLVDLTNFDQTGTAVEKLLDSVNITCNKNTIPNDPKSPFVT
                     SGVRLGT"
     CDS             complement(7304..7585)
                     /locus_tag="ctg79_8"
                     /transl_table=11
                     /translation="MDGMKLFAIYLVVMNVLGVAVMWSDKRRARLHRWRIPEKVLFGVS
                     LLGGSAGTWAGMYLFRHKTKHWYFVVGMPLILVCQAALAIYLVHLYVL"
     CDS             complement(7852..10014)
                     /locus_tag="ctg79_9"
                     /transl_table=11
                     /translation="MKKSKAIVILIVILGALAGLAYYASIILSSTGIGEEMSIPLGLDL
                     SGGVSITYQVVDDNPSAEDMSDTIYKLQKRVEGYSTEASVYQVGDDRITVEIPGVSDAN
                     AILEDLGNPGSLEFQLPDGTVYMTGDQVADAQAGTTTDSYGNKQYVVQLKLTDDGAKLF
                     ADATTDNVGNYLPIVYDGETISYPQVKEAITGGTAQISGMKTYEDAETLATQIRIGSLS
                     LKLQELESSVVGAQLGSQAISSSLKAAAIGLVIVMIFMIVMYQIPGLAAAIALAIYTCL
                     VIATLYLFEITLTLPGIAGIILSIGMAVDANVIIFARIREEIATGKTVNSSMKIGFKKA
                     MSAILDGNITTIIAALVLIALGSGTVKGFAYTLMIGIVLSMFTALVVTRWILYSFYAIG
                     IRDEKFYGRAKERRTLNFLGKRGVFFTVSLAMIAAGFIGMGVHAAKGSGALNYGLDFVG
                     GTSTTADYGKDYTIEEIENTIVPVVADVIGDKDIMANKVEGTTQITVKTRTLTLDERDT
                     LEQALVDQLGADESSITSQSISSTVSSEMRSDAIVAVIVSSICMLIYIWFRFKDIRFGA
                     SAIIALLHDVLVVLAVYSLLRISVGNTFIACMLTIIGYSVNDTIVIFDRIRENLGRTAA
                     KQTPELLAEVANKSLTQTLSRSINTSLTTFIMVFMLFLLGVASIREFALPLMAGLLCGA
                     YSSICIATELWYIMRLHLGKNRLIKK"
     CDS             complement(10001..11383)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Quinohemoprotein_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg79_10"
                     /sec_met_domain="Quinohemoprotein_rSAM_RRE (E-value:
                     3.7e-10, bitscore: 29.3, seeds: 15, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 3.5e-35,
                     bitscore: 109.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.6e-16, bitscore: 50.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 8.3e-14, bitscore: 41.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.2e-19, bitscore:
                     58.3, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIIVVHQYKNNGYDIVLDVNSGAIHVVDDVTYDVIALYEGHTRE
                     EIVNSLRERYPETEVEEALDEVQMLVDNEELFTKDTYENYIMDFKKRPTVVKALCLHIA
                     HDCNLACQYCFAEEGEYHGRRALMSFEVGKKALDFLIANSGNRRNLEVDFFGGEPLMNW
                     QVVKDLVAYGREQEKLHDKKFRFTLTTNGVLLNDEVMEFCNREMGNVVLSIDGRKEVHD
                     KMRPFRKGAGSYDLIVPKFQQFAESRHQDKYYVRGTFTHYNLDFSEDVLHLADLGFKQI
                     SVEPVVAEPKEPYAIREEDLPKLFEEYDKLAVEMIRHHKSGEDFNFFHFMIDLEGGPCV
                     AKRLSGCGSGTEYLAVTPWGDFYPCHQFVGNEKFLLGNVDEGILNTDIRDEFKCCNVYA
                     KEKCRKCFARFYCSGGCAANAYNFSGDICGAYDIGCELQKKRIECAIMIKAAEEEQKNE
                     EE"
ORIGIN
        1 ctcgcagtgg gcaagcgcca cttcctccac cgtgcacgcc ggatgttcca acagatcgtc
       61 tatgatcccc cggtaaaatg ccgcgtactc ctcattgatc cagttgatat agggttcaaa
      121 aaaggaaagc tttgtgtaat ttccggtcag gatcacgtca tagcaggacg ccgcctgttc
      181 tgctgcgccc tgcgctccag cttctcccgt ctcaactgcg gcgccctgcg ctcgcgcttt
      241 tccctgctca gcttcgcctt cctcttctgc ctgccgcaat ccggttcccg caagcggcag
      301 aaagccacgc gacacatact ccggataaaa ctcttcaaaa tatgccttct gtctccggtc
      361 tatactgata tgccggtatt tttccggcag atcttttaac ctgtcatcgt aaaagtacgg
      421 atggtcggcg gcaatattat aacagggaat gtggtaggta tcccagagat aaccgatccc
      481 ctcgcggtac acgcccgcct ccttttccag tccctgaaaa ttgaaggtca caagcaccgt
      541 ctcgcgcggt ctgataaact tgcgcagctt tccagcgctg ctctcctcct gttttagatc
      601 atagaaaaat actgcgtatc ccagtttttg aaactctcct gccatctgat gggagaagta
      661 ggatagtgtc tccactccgc cctccatcat gacaattctt tttatcatgc cagctccttt
      721 ctgtccgcag cgctgtcatt attttttgct tactcatgcc gcagcgcatc gatcggattt
      781 aaattcgccg ccttgtagga cgggaacaca ccgaatacga ttccgataac catggaaaac
      841 gccaccgctc ccacggctgc cggaacactg atcgccaccg gcgtcgtcgt cacatacgag
      901 atcacctgcg ccagaataat gccgaccagc acgccgatga gaccgcccag gctggtgagc
      961 accgccgcct ccgtcagaaa ctgtcccagg atccgggact tgcgtgcccc gatcgccttt
     1021 ttcagaccga tctcctgcgt ccgctccgtc accgatacca gcatgatgtt catgacgccg
     1081 ataccgccga caatcaatga aatgccggca atccagatca gcatggtgtt ggtggagctg
     1141 ctaagttcct gaatctgctg tgcctgctcc atcagatctt ttgccttata ctggatcgtc
     1201 gtatccgaca ccgacagata cccgtttagc agatccgctc ccgcttttcc ggcgctggtc
     1261 atatcatccg tactctccac gcgcagcacc acattctgcg gctcgtcgta ctgatagatg
     1321 atcggccagg tcgtcgccgg cacatacaca gagccggcgg aatcctgcgc gtaggtataa
     1381 tagtcatcaa ttgagttgat gaccggttca aactttttcg cctttgtcac aattcccacc
     1441 acaacatacg gctcctgctg aatctcaatc gtctccccga cagcttcctc tccctggaac
     1501 agtgcgtccg ccgaatcctc atccagaatc gcgaccttgt gatactggtc aaaatcctgc
     1561 tgcgtgaacc cacgcccttc cttcataata taattgcagg tgtcaaaata agccgtgtca
     1621 acgcccttga cataaccacc ggaaagcccg gtattcagat gatagactcc gttgtaatcc
     1681 tgccggctca gatagcgcga cacattttcc acatgcggga tctccttgag ctgttcaacc
     1741 acctcatccg ccacaagcgg cacgccctcc ggtatgccgt tgtactccat ctcatattcc
     1801 cactctccct gatacaggga aatctcgacg gtattctcac cggctccgac caggttctgc
     1861 ttgatctgct catttgttcc cttaattgta gatacaatcg caataatagc tgcaataccg
     1921 ataataattc ccagcatcgt caggaaggaa cgcatcttgt gagcccagat tccgcggaaa
     1981 gataatctta tattttcaaa catctccgtt cctcctttaa taattggatg attcgtccgt
     2041 gacggcagcg ccctccaccg catttttccc gtacgggaat gcgatgcggt cgtcctccgt
     2101 cagacccgac ttgatctcta ccgcagatcc gtacaccgtt cttccggtca ccacatactg
     2161 ttttttcagc cggttattct catctgcaat catacagtac gcctttccat cctccgacct
     2221 cacatacgct ttttctataa aaatgccgcc gccatcggac tgattggtcg atatggacag
     2281 atctaccgcc tccccgttgc ggagcgcgga actgtcctcg atataagccg tgtactcata
     2341 ataggagaca ttgggatttc catcgcccca cgagttgccc gaaaccggat aatccgatat
     2401 ttccgtgatt gtggcatcga acgtcatacc gctctcccag gaattggcac tcaccacggt
     2461 tcccatcttc acatcatcca aaagcagctc gctgatcgtc ccctttacat agagcccgtc
     2521 atctccggtt atcaccagaa acgcctgccc ctgctcgggc ttctcgtccg gatcaccgag
     2581 cgtcttgacg acaccgtcca cctccgcgta gaccacaccg tccgtcgcac ttttctccat
     2641 ggactcgagc gccagctgtt cctgtctgcg ctgaatatcg agcgtcttta atttttcttc
     2701 aatctcggca gcctcctgat agagttcctc ggaagtatat ccctttggca cctcccagtc
     2761 cgccataaaa tcctcgtagg cctgcatgta ctcatccgca agggaggtcg gtatgtattc
     2821 ttttcccgaa aacagatacc acatgcggct ctcatcgtaa tccgccggaa aatcgctgcc
     2881 gtttaactcg acggtattcg gggacactgt atcatccgca accggcgtct gccgcccggt
     2941 cgcttcatcg gtgtcaagca ccatcttacc gtccgcatcc ttcttgcaga cgatcacgcg
     3001 cacatgtttt ccgctgcctc cctccgcggt aggacggatg gcattgaaaa agccgccgta
     3061 ggcgtatgca ttctggttga cataataaat atacggttct tccgctgttc ctgccggata
     3121 caccagttcc cccgccgcat tggttgtcac gttgtaggga atggaggccg ccgtcagata
     3181 gttgtagatt ctgctgtcgt tcttatctgt ctctgtcagg cggttttcct cgtccatgtg
     3241 ctgataccag gcaagctgct cctcgttcag cttcggcgga tcttttttca ccggcgtctg
     3301 cgtctttaac atttcatact tgtatttttg tctctcgatg ttattctcga tcgtgctgat
     3361 atcgagtttt ttgcgttcaa tctctatctg gagttccgcc gtgtcatagg cgagcaacgg
     3421 gtctcccttt tgcacctcat cccccttctc cacatagatc tccttgatca ttctggaatc
     3481 atccagatag atctcctgtg aggaatcgtt cgtgacggtg ccgtaacttg tctccgtgtc
     3541 tccccagtat ccccagttga ggttggaaac cggctgcact tccgcgataa gctttttgtc
     3601 ctgataggac ttatacccgt atacgcctcc caccgcagcc gagagggtga ccgcaatacc
     3661 tgcgatgacc gcaatcactt tcttaatctt catgatactg ctccgtcctc ctccccctca
     3721 tagatctcac cgtcgatgat ccggacaatc cgcttggctt tcgccgcgat cttgggatca
     3781 tgcgtaatca tgacaatagt aacgccctct tcgttcaaac tgtcaaaaag ctccatgatc
     3841 tgctcgccgg atttggagtc cagggctcct gtcggctcat ccgccagcag aatcttagga
     3901 tggttgacca tcgcgcgggc gatggcgaca cgctgcttct gtccgccgga aagctgtgtc
     3961 ggcctgaaat tgacacgatc cccgagtcct actctctcga gcgctttcgt cgcgcggccc
     4021 cgtctctcct ttttgcgcac tccggcatag ctgagcggaa gcgccacatt ttccacggca
     4081 ctctcccgcg gcatcagctg aaagctctgg aacacgaacc cgatactttt taagcggaga
     4141 tccgagagct ccctgtcttt taatttgagc acgttctccc ctgccagctc ataagtaccg
     4201 ctcgtcgggc ggtcgagaca cccgataata ttcatcagtg tggtcttacc agaaccggac
     4261 ggtcccataa tggcgacata ctctccttcc tcgaccgtca gcgatacatc ctttaacacc
     4321 ggcacaacca gcttctcctg ctgatagtct ttgtagatat tctgcagatt cagtatcatt
     4381 ctgccacctc cgcctctgtc ccttctccga catccatgct gtcatacatt tcatccggca
     4441 gttctgtatc atagacgctg tccaacacat tatagagcag ttccgtatca tagacaccct
     4501 ctgtatcgta cagattctcg tccgccggct gattgtaaag cggagaagaa taatccactt
     4561 ccgcctcgtc agtcacggtc gtcacaccct catagagacc agccatcggc caggcaatgt
     4621 aatcgtcctc ggcaagccct gatacgatct catactcgtc catatccgca tcgtactctc
     4681 ccagctcgat gtagcgcttc tccagacggt ttttctcatt agccgcccac acgtacggag
     4741 tatcttcgtc ctgcacgatg taggagccgt acagccacag accttccttc acttcctcct
     4801 gtccctgatc cagctcgatg tacacatgct gccccaggat cagtccgtcc accgagtcga
     4861 gatccacata gaacggatac ttggacgctg actgcgtgtc tcccgccgaa gaggtgctgt
     4921 aataaccgtt gtcattcccc tgctgcggac tctccgtgtc aattttcccg atcgttccgc
     4981 tccacgtctt cgtactgtct acacgcgaac ggatcacaac ctcctgcccc tcggaaagca
     5041 tccagacatt ctgctcatcg atgcttccct tgatccggta ctctccggtc tgtaagatcg
     5101 tcataaacgg cgcgctgttc ccgttgctgt ccacgccttt ctcattgatc tccttgacca
     5161 ctcccgccac cttgctcaca acggaagaac tgctgacctg tttctgctcc ttggagatct
     5221 caagcttctt gctctccata tcgaactgct tctgtgcgat ggagttctgg atattctgga
     5281 tctgcgtggt gtaatcgtaa cgttccgatt cttccacctt ctccatctct ttcgtcagtg
     5341 tgtcgatctg tttgttgtaa ttatctatct cattctgaat gccttccagt tccagcttcg
     5401 cctgctcaat cttcatggta agatcactgg tgtcgtaagt gaccagggtc tgtccctcct
     5461 cgacctcatc gcctgcctcc actttgatct cgctgatcgt ccgggaagaa tccacattca
     5521 cctcgtatga atcctgcgtc tccaccacac cgttataccg gttggaaaca cctgcatact
     5581 gattcataat acgggatacc ttttccacat agaccttgtc ctctgaactt ccatcatcaa
     5641 agatcggtat catctgcctg atatcatccc ggaaataata accggttcct cccagaacag
     5701 cagccactgc tgccacaccg atcagaattc caacgctctt tttgcccata gctcctcctc
     5761 tgccccagac gggttacttt cttttcttta ttctatcatc ttttcagacc cgatacatag
     5821 tgtttaattc ttaataattt ttgtagagta gaacattaaa aaagcctccg cgcatattga
     5881 acactcacaa tatgcacgga agcctagtct acacactttg aaagatttta ttttaacgga
     5941 tactttgcgg tgagctccgc cacaatcgct ctggcgcgat ctgccgccgg ctctccctcc
     6001 ttgatcatca tggcaatcgc ctccgcaatc tgatccatat ccccggtatt gaatccgcgg
     6061 gatgtcaccg ccggcgtacc gagacgcaca ccactcgtca cgaacggaga cttcggatcg
     6121 ttcggaatcg tatttttatt acaggtgata tttacggaat ccagaagctt ctccaccgct
     6181 gttccggtct gatcaaaatt cgtcaggtcg acaagcatca ggtgattgtc ggtgcctccc
     6241 gatacgatct tgataccgcg gttcatcagt cctttgcaca gcgcctgcgc attgtcgatg
     6301 atgttctgct ggtacacctt gaactccggc tgcagtgctt ccttgaagca gactgccttc
     6361 gccgcgatca catgcatcag cggacctccc tggattcccg ggaagatcgc cttgttaaag
     6421 ttgtacttgt ctgctgcttc ctgattgcag agaatcattc cgccgcgcgg tccgcgcaga
     6481 gtcttgtgcg tggtcgttgt cacgacatcc gcatacggga tcgggcttgg atgaagtccc
     6541 gccgcaacca gaccggcgat gtgcgccatg tcaaccatga gcacagcacc gcaggcgtcc
     6601 gcgatctcac ggaatttctt aaagtcgatc gtgcgcgcgt aggcactggc accggcaatg
     6661 atcatcttcg gcttgcactc aagggcaatc tccatcacct tgtcgtaatc gatgaatccc
     6721 tcgtcattta caccgtacgg tacgatatga aaataggttc cggaaaaatt gactggtgag
     6781 ccatgcgtaa ggtgtccgcc atgatccagg ttcataccca tcacggtgtc gcccggcttt
     6841 aaaacagcga actgcactgc catattcgcc tgtgctccgg aatgtggctg cacgttgaca
     6901 tagtcacagc cgaatagctt cttcgcgcgc tctcttgcca gctcctccac gacatccaca
     6961 cagtcgcatc cgccgtaata gcgcttcccc ggatagcctt ccgcatattt attagtcaaa
     7021 acgcttccca tcgcagacat caccgccggg cttacccagt tctccgatgc gatcagctcg
     7081 atatgactgt tctgtctgtc aaactcatcc tttattgcct gtgcgatttc catatctacc
     7141 gcttcgatat cttccattgt atacatcgta tgtattctcc cttcctgaac cgccgcagtg
     7201 tctttctacg aagaacattt gtctttctac ggctatgcta ctcattataa atgactttgt
     7261 atctttattc aatcagaaaa cacataccgt ctataacaat ttgttataaa acatataagt
     7321 gcaccagata aattgcaagt gccgcctggc aaaccagaat gagcggcatt ccgaccacaa
     7381 aataccagtg cttcgtcttg tggcggaaca aatacattcc tgcccaggtt cccgcgcttc
     7441 ccccgagcag gctcacgcca aagagcacct tctccggaat ccgccaccgg tgcagtctgg
     7501 cgcgcctctt atccgaccac atgaccgcca caccgagcac attcataacc accaaataga
     7561 ttgcaaacaa cttcatccca tccatctcat ttctcctcaa tgaccgtttt catgtcactc
     7621 cacaaactgg acatccagat ctaccgctcc ctcaattcca tccacacttc cctttttcac
     7681 tgtactgcca gaaggtaaat atggcagggt caatctctgc gtcatgccat tatacacgct
     7741 atcctacgtt tcttcatgcc tgcttcccgt tattttcctt tttcctgcag ggaaatagaa
     7801 aggactgcaa atacatcttt ggtcaatgta ttgcagcccc taatatttgt tttatttctt
     7861 gatcagtctg ttcttgccaa gatgcagtct catgatgtac cacagctccg ttgcaataca
     7921 gatggaagaa tatgctccgc agagcaggcc tgccatcaac ggaagtgcaa actcacggat
     7981 acttgcaaca ccgagtaaaa acaacatgaa taccatgata aaggttgtca gagacgtatt
     8041 gatgcttcgt gaaagcgtct gtgtcaagct cttgttggca acctccgcca gaagctccgg
     8101 cgtctgcttt gctgctgtcc tgcccaggtt ctcacggata cggtcaaaaa taacgatcgt
     8161 atcattgaca gagtaaccga tgatcgtcag catacatgcg ataaaggtat ttccgacgga
     8221 aatacgaagc agtgaataaa ccgcaagcac taccagcaca tcgtgcagca gcgcaataat
     8281 cgcacttgca ccgaaacgga tatccttgaa ccggaaccag atataaatca acatgcagat
     8341 cgaagatacg atcacggcaa caatggcatc ggaacgcatc tcactgctga cagtcgagct
     8401 gatactctgt gatgtgatgg aagactcatc tgctccaagc tgatccacca atgcctgctc
     8461 cagcgtatct ctctcatcca gcgtcagggt acgcgttttc accgtaatct gtgtcgtacc
     8521 ttccactttg ttcgccatga tgtccttgtc gccgatcaca tccgcaacaa caggaacgat
     8581 ggtattctca atctcttcaa tcgtgtaatc cttgccatag tctgctgtcg ttgaagtacc
     8641 tcctacgaag tcaagaccat agttcaatgc tccgcttccc tttgctgcat gaacacccat
     8701 tccgataaat cccgctgcaa tcattgccag ggaaactgta aagaatacgc ctctctttcc
     8761 gaggaagttc aacgtcctgc gctcttttgc acggccatag aacttctcgt cacggatacc
     8821 gatggcatag aaggaataca ggatccatct cgtcacaaca agtgccgtaa acatggaaag
     8881 cacaatacca atcatcagag tgtatgcaaa gcccttgact gttccggaac ccagcgcaat
     8941 cagtaccagc gccgcgatga tcgttgtgat gttaccgtca aggatggctg acattgcctt
     9001 cttaaaaccg atcttcattg aagaattgac cgtcttgccc gtcgcaatct cctcacggat
     9061 acgcgcgaag ataatgacgt tcgcatcgac cgccataccg atacttaaga tgatacccgc
     9121 aatacccggc agtgtcagtg taatctcaaa taagtataat gtagcaatta ccagacaggt
     9181 atagattgcc agcgcgatgg ctgccgccag acccggaatc tgatacatca ctatcatgaa
     9241 gatcatgacg atcactaatc cgatggctgc tgcctttaag ctggaagaga tcgcctgact
     9301 tcccagctgt gctcctacaa cgctggattc cagctcctgc agctttaagg aaagagaacc
     9361 gatacggatc tgtgttgcca gtgtctcggc atcctcatac gtcttcatgc cggaaatctg
     9421 tgcagtaccg ccggtgatgg cttcctttac ctgcggatag ctgatcgtct cgccatcata
     9481 cacgatcggc agataattgc cgacattgtc tgtggtggcg tccgcaaaca gctttgctcc
     9541 gtcgtctgtg agctttaact gtaccacata ctgcttgttg ccgtagctgt ctgtcgtggt
     9601 tcccgcctgc gcatccgcaa cctggtcacc cgtcatgtaa accgttccgt ccggaagctg
     9661 gaactccaga gaacccggat taccgagatc ctccagaatc gcattggcat ccgatacgcc
     9721 agggatctca accgtaatac ggtcatctcc cacctggtag acagacgcct ccgtgctgta
     9781 gccctctaca cgcttctgca gcttgtagat cgtatcactc atatcctccg cactcggatt
     9841 gtcatccaca acctgatagg taatggaaac accgccggat aaatccagac caagcggaat
     9901 gctcatctct tccccgattc ccgtcgaaga aagaatgatg gatgcataat aagcaagtcc
     9961 cgccagtgca ccaaggatca cgatcaaaat aacaatcgct ttactcttct tcattctttt
    10021 gttcctcctc tgcagctttt atcataatcg cacattcgat gcgctttttc tgaagctcac
    10081 atccgatgtc atatgctcca cagatgtcgc cgctgaaatt ataggcattc gccgcgcagc
    10141 cgccactgca gtagaatctt gcgaaacact tgcggcattt ctccttcgca tagacattgc
    10201 agcatttaaa ctcgtcgcga atgtctgtat ttaagatgcc ctcatcgaca tttccgagaa
    10261 ggaacttttc atttccgaca aactgatggc acggatagaa atcgccccac ggggtgaccg
    10321 ccagatactc ggttcccgaa ccgcagccag aaagccgctt cgccacacac ggaccgccct
    10381 caagatcgat cataaagtgg aagaaattaa aatcttctcc gctcttatga tgtctgatca
    10441 tctcaactgc cagcttgtca tactcctcga agagcttcgg cagatcctcc tcccggattg
    10501 cgtacggctc cttcggctcc gccacaaccg gctccaccga aatctgcttg aatccgagat
    10561 ctgcaagatg cagcacatcc tccgagaaat caagattata atgtgtaaag gttcctctca
    10621 cataatactt atcctgatgt ctgctctccg cgaactgctg gaacttcggc acgatcagat
    10681 catagcttcc cgcacccttg cggaacggcc gcatcttatc gtgaacttcc ttccgtccgt
    10741 caatacttaa aacgacattc cccatctcgc ggttacagaa ttccataacc tcatcattta
    10801 aaagtacacc gtttgttgtc agcgtaaagc gaaacttctt gtcgtgaagc ttctcctgct
    10861 ctctgccgta tgccacaaga tccttgacca cctgccagtt cataagcggt tccccgccga
    10921 agaaatccac ctccaggttg cgtctgttgc cggaattggc aatcagaaaa tcaagtgcct
    10981 tcttcccgac ttcaaaggac ataagagccc ttcttccgtg gtactcaccc tcctcggcaa
    11041 agcaatactg acaggcaagg ttgcagtcat gcgcaatgtg caggcacaga gccttcacaa
    11101 ccgtcgggcg ctttttgaaa tccatgatat agttctcgta ggtatccttc gtaaaaagct
    11161 cctcattgtc gaccagcatc tgcacctcat caagtgcctc ttccacttca gtctccggat
    11221 agcgctcccg cagagaattc acaatctcct ctcttgtatg tccttcatac agggcaatga
    11281 catcgtatgt cacgtcatcc accacatgaa tcgcgccgct gtttacatcc agaacaatat
    11341 catagccgtt gttcttatac tgatgaacca ctataatatt tcctc
//
