LOCUS       c00078_gnlPro..        14519 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IGCMKJBP_78.
ACCESSION   c00078_gnlPro..
VERSION     c00078_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 19:22:12
            Original ID  :: gnl|Prokka|IGCMKJBP_78
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14519
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14519
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1583:6814]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1584..6814
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14519
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14519
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             190..1398
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_1"
                     /sec_met_domain="Peptidase_S11 (E-value: 2.4e-51, bitscore:
                     164.3, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYRRFLSLLLSMSLLIFSPVRVRAQDVPAESELYAKSAVLMDADS
                     GRILYEKNGHEAMANASTTKILTCIVALENCDPASVVTVSKNAASQPKVHLGMHEGQQF
                     YLRDLLYGLMLESYNDCAVAIAEFAAGEVQGFAALMNAKAEELGCEDSYFITPNGLDAK
                     DDAGVHHTTAADLAKIMKYCIKESLKSDEFLEITRTAQYSFSDAEGKCTYQCTNHNAFL
                     QMMEGALSGKTGFTGTAGYCYVGALQREDKTLIVALLACGWPNNKTYKWSDTRKLMNYG
                     LEQFKKIDLLQIEPDEAELAPIEVRDGQGGQIGETVYLKPVVRNYAGEESILAPLSSEV
                     TLKYEIADQLYAPVKSGDYIGKIRYMLGEETLAERCVVAGETIGKIDYPWCLGQVLRLL
                     WIE"
     CDS             1584..3020
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_2"
                     /sec_met_domain="CT_Vparvula (E-value: 3.5e-125, bitscore:
                     408.3, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSSNDSLAMQRITRLVDENSFIEIGSLVTARSTDFNLAATDTPS
                     DGVITGHGLIDGNLVFIYSQDASVLNGTIGEMHAKKIAAVYDMAMKMGAPVIGFIDCAG
                     VRLQESVDALDGFGLIYAKEVAASGVVPQISAVFGSCGGGLAVVPALSDFAFIEESKGK
                     MFVNSPNAIDGNRIEKCDTSSAAFQADENGCIDATGTEDEILADIRELVGMLPLNNEGD
                     VYTDECADDLNRACESMDAMKGDPRYLLSEISDSHTFFETKAGYARDMVTGFIKLNGMT
                     VGAVANCTTVYDEEGKESEKFDNVLSAKGCEKAAEFVSFCDAFEIPVLTLTNVKGYKAC
                     KCSEKRLAKALAHLTSAFAGATCPKVNLITGEAYGTAYVAMNSKSIGADFVYAWPDAKV
                     GMMDADLAVKIMYADASADELAEKAKEYDALQGSVMTAARRGYVDLIVDPADTRKYLVD
                     AFELLYTKCAYTPDKKHGTK"
     CDS             3007..3759
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_3"
                     /sec_met_domain="OAD_gamma (E-value: 5.7e-26, bitscore:
                     81.0, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQNRKVKFMKKKLSLILCLCFMALGLAACGTDPTTVDYFGMTYD
                     ELQSSMEQEVSALVGLTDDNRTYIQSYGSDTAMKLVESWDEATSDVGAYQGLGEFNITK
                     AQKTLTVDQYVEYQNREVIVSYIYTYNYETEQPELTDASADKVYTLGEKMEKAALNTLM
                     GMGTVFVVLILISLIIYCFRFISVIQNKAAGKGKKNEAEAGAVVEQIGQREEQLTDDLE
                     LVAVISAAVAASTGASADSFVVRSIRRR"
     CDS             3801..4166
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 61.7; E-value:
                     1.5e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 3.3e-20, bitscore:
                     61.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGNVYDVTVEENGAVSAPAAAPRRAAAPAAAPAAKPA
                     AAAGAGSVKIEAGAAGKVFKLEKSVGDAVKKGDSIMVLEIMKMETPVVATQDGTVASIN
                     VSVGDMVEAGALLATLN"
     CDS             4182..5330
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_5"
                     /sec_met_domain="OAD_beta (E-value: 3.1e-157, bitscore:
                     512.8, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYFSETMGNLLHQTAFFNLTWGNFVMIIVACFFLYLAIAKGFEP
                     LLLVPIAFGMLLVNIYPDIFADPEQMSNGVGGLFHYFYVLDEWSILPSLIFLGVGAMTD
                     FGPLIANPISFLLGAAAQFGIFGAYFLAIMMGFNDKAAAAVSIIGGADGPTSIFLAGKL
                     GQSGLMGPIAVAAYSYMALVPIIQPPIMKLFTTKKERAIKMENLRPVSKLEKILFPIVV
                     TVVVCTILPTTAPLVGMLMLGNLFRESGVVRQLTDTASNALMYIVVILLGTSVGASTSA
                     EAFLNTTTLKIVALGLIAFMFGTAAGVLFGKLLCFLTKGKINPLIGSAGVSAVPMAARV
                     SQKVGAEEDPTNFLLMHAMGPNVAGVIGTAVAAGVFMAIFGI"
     CDS             5396..6814
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_6"
                     /sec_met_domain="HMGL-like (E-value: 1.1e-45, bitscore:
                     146.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 1.4e-59, bitscore:
                     191.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEVVKKPLKITETVLRDAHQSLIATRMTTEQMLPIVDKMDKVGY
                     NAVECWGGATFDACLRFLKEDPWDRLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSIANGIDIIRIFDCLNDVRNLQTAVTACNKEKGHAQVALSYTLGDAYTLDYWME
                     MAKKVEDMGADSLCIKDMAGLLVPTKATELIQALKSATNLPIELHTHYTSGVASMTYMK
                     AVEAGCDIIDTAMSPFSMGTSQPATEVMVEAFKGTEFDTGLDQNLLAEIADYFRPMREE
                     ALESGLMNPKVLGVNIKTLLYQVPGGMLSNLLSQLKEQGKEDKFEEVLAEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKVATKETKDVLLGKYGQTVKPFNPEIVDKVLGE
                     EKKNAITCRPADLLEPELDKIEAEMKQWKQQDEDVLSYALFPQVATEFFKYREAQQKKV
                     DASVADTKNGAYPV"
     CDS             complement(6878..7360)
                     /locus_tag="ctg78_7"
                     /transl_table=11
                     /translation="MRDITPATNFIHTLMQSPPDASAWIAGGNNFPSISGLARFYATEY
                     EGTLVEVEVFGLPNVAAPGSSNFYGMHIHENGVCVSPFTSAGAHYSRTPAEHPNHSGDM
                     PPLLGNQGYAWMAFYDKRFTIPEIIGKSLIIHRMPDNFTTQPAGDSGERIACGVIK"
     CDS             7522..8454
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_8"
                     /sec_met_domain="SIS (E-value: 1.6e-24, bitscore: 76.1,
                     seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNTNDLSNRINDAYSKLSKGQKRLATYITDNYDKAVFLTAAKLG
                     EVVGVSESTVVRFATHLGYKGYPEFQSALEELVRNKLNSIQRMEVTYGRISQSKILETV
                     LKSDADKIHSTLEKIDQNAFELAVDTILHAKHIYIIGIRSCAPLASFMAFYFTLMFPNV
                     HLIQTSSSSEIFEQMVRIGKEDVIIGISFPRYSMRTLKAMEFANNRSAKVITLTDSVHS
                     PMNLYSSCNLIADSDMASIVDSLVAPLSVINALIVALCMKKQNEVAKTLEMLEDIWDEY
                     QVYENDEINYIDDSIKMRYGKVGDAELYE"
     CDS             8447..9676
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 58.4; E-value:
                     2.2e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_9"
                     /sec_met_domain="HI0933_like (E-value: 5.6e-137, bitscore:
                     446.5, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVIVVGGGPAGMFAAIAAAERGHEVVLLEKNEKLGKKLYITGK
                     GRCNITNAGDMDTLFANVMTNPKFLYSAFYDYDNQRVIDFFEENGLATKVERGNRVFPV
                     SDHSSDVIATLQRVLKRTGVMVQLHAEVRQILTGEGAVRGVKLADGSVLEAERVILATG
                     GFSYQTTGSTGDGYRFARELGHTVTQITPSLVPFYVKETCAARMQGLALKNVQVRIRDG
                     KKLLYDEFGEMLFTHFGVSGPLILSASAAIKPGRVEKELAMEIDLKPALTEEQLDARLL
                     REFEEAKNKQFKNAVVHLFPAKMIPVMLEAGAIDPEKKVNEITREERMGFVHLIKAFPL
                     TLCGVRDFNEAIITRGGVSVKEVNPSTMESKLVPGLYFCGELLDLDAMTGGFNLQIAWS
                     TGHLAGESIE"
     CDS             9695..10357
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytidylate_kin"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_10"
                     /sec_met_domain="Cytidylate_kin (E-value: 5.9e-81,
                     bitscore: 261.1, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMNIAIDGPAGAGKSTIAKKLAKKLAFVYVDTGAMYRAMAYYFL
                     QNGIAPDDEQAIAAACPKVDVTIVYENGEQQVLLNGENVNGVIRTEEVGNMASATSVYP
                     VVRTKLVELQRQLATKTDVIMDGRDIGTCVLPDAQVKIYLTASVATRAKRRYDELTAKG
                     TQCNLEEIEKDIEDRDYRDMHRETSPLKQAKDAVLVDSSEMNIDEVVDAIYQIYARV"
     CDS             10363..11214
                     /locus_tag="ctg78_11"
                     /transl_table=11
                     /translation="MNVILAKSAGFCFGVKRAVDTVYERILEKEPLYTFGPIIHNEEVV
                     RDLEEKGVVVVNDVDELAGKPQGTVIIRAHGVERGVCEKIQALGFSIVDATCPFVLKIH
                     RLVERYSGEDCHIVIVGNASHPEVKGIKSWSNAEDTRVIGTREEAEKYDASHGKKVCIV
                     SQTTFNYNKFQELVEIIKEKGYDIIVLNTICNATEERQTEARAIAEQVDAMIVIGGRNS
                     SNTQKLFEICKNECKNTYYIQTVKDLDLAEVRSVDNVGITAGASTPNNIIEEVQKNVRN
                     EL"
     CDS             11195..12313
                     /locus_tag="ctg78_12"
                     /transl_table=11
                     /translation="MSEMSFEQMLEESFKTIRNGEVVEGTVIDVKPDEIVLNIGYKADG
                     IITRNEYTNEANVDLTTLVSVGDTMEAKVLKVNDGEGQVLLTYKRLAAEKGSKRLEEAF
                     ENKEVLTAKVAQVLDGGLCVNVDETRVFIPASLVSDTYEKDLSKYKDQEIEFVISEFNP
                     KRRRIIGDRKQLLVAKKLEQQKELFARIKIGDVLEGTVKNVTDFGAFIDLGGADGLLHI
                     SEMSWGRVESPKKVFKVGDQVRVFIKDINENKIALSMKFPAENPWNGAAEKFAIGNVVK
                     GKVARMTDFGAFVELAPGVDALLHVSQISKEHVEKPSDVLKVGQEIEAKIVDFNEEEKK
                     ISLSMKALLAPEEDADADVADVDIDAVAKEEE"
     CDS             12420..13202
                     /locus_tag="ctg78_13"
                     /transl_table=11
                     /translation="MLETDNYEKFKKDILALAKIDLNSYKEKQMRRRINTLITKNHIAT
                     YDEYVALIKKDKEKFEQFINFLTINVSEFYRNPDQWKILENEVFPKLIQKFGKNLKIWS
                     AACSTGDEPYSLVMALSRHLPLANIKVIATDIDKQVIDTARMGLYNEKSIASVPDDLKK
                     KYFTKVGNSYQISDEIKKRVEFKEHDLLKDPYPGGCNLIVCRNVVIYFTEEAKDEIYAK
                     FYKALATGGVLFIGSTEQIMNYREIGFERDKSFFFEKA"
     CDS             complement(13328..14518)
                     /locus_tag="ctg78_14"
                     /transl_table=11
                     /translation="REIYAFPDLHCGKIGTLTLILHTEDFQMITWHEELTFDFSDPVSN
                     EVFTENCIFFDIETTGFSPARTDLYLIGCATRRDSLLCIDQFFSENAADQKNVLSAFLE
                     LLSGYDTILTFNGIGFDIPYLKAKCKALHLSDPFDAHSYIDLYKEVSRFKFLFALTSYK
                     QKSIELFLGIDRIDAYSGGELIEVYKEYVRHPAKDSLALLKQHNYEDVLYMPKLLPVLS
                     YPKLWEQAFSLQSLQASEYRSMDGASGNKELFFTLALQYPVPKPVSFSYDDCYLSMSGS
                     TARLRVRLFEGELRFFYDGSPKDYYYLPAEDIAVHKSIASAVDKEHRVQANASNCYGKK
                     YAIFLPQYDAMFSPVFREQPRGRKCYFELSADFAADPAMQTDYVLHLLETMRSHRK"
ORIGIN
        1 aatgctcaca tttttctcca acgaatattc catctgcatt tccacatgaa atccccaagt
       61 gtgtttctaa taatattact tatcaaagca cgatatgctt attgcggcag ttccttttta
      121 cataccgttt ctgttctgca aaaaatgagg gacgcatata catcagtgaa gtcattttgg
      181 gagaatggca tgtatcgacg ctttctttct ctattgttaa gtatgagctt acttattttt
      241 tcgcctgtgc gtgtccgggc gcaggatgtg ccggcagagt cggaactgta cgcaaaatct
      301 gccgttttga tggatgcgga ttccggaaga attctctatg agaaaaacgg gcatgaagcg
      361 atggcgaatg cgagcacgac aaagattcta acctgtatcg tggcactgga aaactgtgat
      421 ccggcgagcg tggttacggt gtcaaaaaat gcggcgtccc agccgaaggt acatctgggg
      481 atgcacgagg gacaacagtt ttatctgagg gatcttttat atggcctgat gctggaatcc
      541 tacaatgact gtgcggtggc catcgcggaa tttgcggcgg gggaggtgca gggatttgcc
      601 gcgctgatga atgcgaaggc agaggaactc ggctgtgagg acagctactt tattacaccg
      661 aacggactgg atgcgaagga tgatgccggg gttcatcaca cgacggcggc agaccttgct
      721 aagattatga aatattgtat taaggaatcg ttaaaaagcg acgaatttct cgagattaca
      781 cggacggcgc agtattcttt ttctgatgca gaggggaaat gcacgtacca gtgcacgaac
      841 cacaatgcat ttttgcagat gatggaaggg gcgctttccg gaaaaacggg atttaccgga
      901 accgccggat actgctatgt cggagcgttg cagcgggagg acaaaacgct gatcgtggcg
      961 ctgctcgcct gcggatggcc gaacaacaag acctataagt ggtccgacac cagaaaactc
     1021 atgaattacg gattggagca gttcaaaaag atcgacctgt tgcagattga gccggacgaa
     1081 gcggagcttg cgcccataga ggtgcgggac ggacagggcg gacaaatcgg cgaaacggtg
     1141 tatttaaaac cggttgtcag gaactatgca ggggaggaga gtatcctggc gccgctaagc
     1201 agtgaggtta cgcttaagta tgagattgca gaccagctgt atgcaccggt gaagagcggc
     1261 gattacatcg ggaagattcg ttatatgctg ggggaggaga cgctcgcgga gcgatgtgtg
     1321 gtagccgggg agacaatcgg aaagatcgat tatccgtggt gtctggggca ggtgcttcgg
     1381 cttctctgga tcgaataaaa aacacaaaca aaaagcgtca aaaaattaac aatttacttg
     1441 aaatattgca gaaaagcaat tataatttaa catagcgtaa tttgttgaat ttttatacaa
     1501 agacgcatgg atttacatca ttcactatga agccacatcc caaatggatg tggacaacaa
     1561 tttatagatg gagggcaaaa agaatgaata gtagcaatga tagcctggct atgcagcgca
     1621 tcaccaggtt agtcgacgag aacagtttca ttgagatcgg ttctctcgta accgcaagaa
     1681 gcacagattt taatcttgca gcaacggata ctccttccga cggagtcatc acaggacacg
     1741 gcctgattga cggcaatctg gtgttcattt acagccagga cgcttctgtt ttaaacggaa
     1801 caatcggcga gatgcatgcg aagaagatcg ctgcagtgta tgacatggcg atgaagatgg
     1861 gagcaccggt gatcggcttt atcgattgcg cgggagtccg tttacaggag tctgtagatg
     1921 cgcttgacgg cttcggactg atctatgcaa aagaagttgc agcatccggc gtggttccgc
     1981 agatttcagc cgtattcggc agctgcggcg gtggactggc agtggtaccg gcactttctg
     2041 attttgcttt tatcgaagaa tccaaaggaa agatgtttgt gaattctccg aacgcaattg
     2101 acggaaaccg catcgagaag tgcgacacat catctgcggc attccaggca gatgagaacg
     2161 gctgcatcga cgcgacggga acagaggatg agatccttgc agacatccgt gagctggtcg
     2221 gcatgcttcc gctcaacaac gagggagatg tctacacaga cgagtgtgcg gatgacctga
     2281 accgtgcatg cgagagcatg gatgccatga agggtgatcc gagatatctt ctcagtgaga
     2341 tttcggacag ccatacattc ttcgagacaa aggcaggcta tgccagagat atggtgaccg
     2401 gatttatcaa gttaaacggt atgacggtcg gcgcagttgc aaactgcaca acggtatacg
     2461 acgaagaggg caaagagagc gagaagtttg acaatgttct ttctgcaaag ggatgtgaga
     2521 aggcagcaga gttcgtatct ttctgcgacg cattcgagat tccggtactg actctgacaa
     2581 atgtcaaggg ctacaaggca tgcaagtgct ctgaaaagcg tcttgcaaag gcacttgctc
     2641 atctgacctc cgcatttgcg ggagctacat gtccgaaggt gaacctgatc acgggagagg
     2701 catacggtac cgcttatgtt gctatgaatt ccaagtctat cggtgcggat ttcgtatatg
     2761 catggccgga cgcaaaggtc ggcatgatgg atgcggatct tgcagtaaag atcatgtacg
     2821 cggatgcatc tgcggatgag cttgcagaga aggcaaagga atatgatgca ctgcagggca
     2881 gcgttatgac agcagccaga agaggctatg tggatctgat cgttgatccg gcagatacga
     2941 gaaagtatct ggtagatgcg tttgaactgt tatacacaaa gtgtgcatat acaccggaca
     3001 agaaacatgg aacaaaatag aaaggtgaag tttatgaaga aaaaattatc tcttatactt
     3061 tgtctttgct ttatggctct gggacttgca gcatgcggaa cagatccgac aacggttgac
     3121 tatttcggaa tgacttacga tgaactgcag agcagcatgg aacaggaagt ttccgcgctg
     3181 gttggtctta cggacgacaa cagaacctat atccagtcct acggcagcga tacggcaatg
     3241 aaacttgtcg agagttggga tgaggcgaca agtgatgtcg gcgcatatca gggacttgga
     3301 gaattcaata tcacaaaggc acagaaaacc ttaacagtag atcagtatgt agagtatcag
     3361 aatcgtgaag tcatcgtttc ttacatctat acatacaatt acgagaccga gcagccggag
     3421 cttactgatg catccgcgga caaggtatat acgctgggtg agaagatgga gaaggctgcg
     3481 ttaaataccc tgatgggaat gggaaccgta ttcgtggttc tgatcctgat cagccttatt
     3541 atttactgtt tccgctttat ctctgtaata cagaacaagg cggccggcaa gggcaagaag
     3601 aacgaggcag aggcaggcgc tgtggtagag cagatcggac agcgtgaaga gcagcttacc
     3661 gatgatcttg aacttgtggc agttatttcc gcagcggttg cggcaagcac cggtgcatcc
     3721 gcggattctt tcgttgtgag atcgatccgc agacgctaat tcgtataaat gaaaagaaat
     3781 catattagga ggatatttca atgaaaagct atacaattac agtaaacggc aatgtatatg
     3841 atgtaaccgt agaagagaac ggcgcagtga gcgcaccggc agcagcaccg agacgtgcag
     3901 cagcaccggc ggcagcacct gcagcaaagc cggctgctgc agcaggcgca ggcagcgtta
     3961 agatcgaggc aggcgcagca ggaaaggtat tcaaacttga gaagtctgtc ggtgatgccg
     4021 ttaagaaggg agacagcatc atggttcttg agatcatgaa gatggagact ccggtcgttg
     4081 caacgcagga cggtacggta gcaagtatca acgtaagtgt tggagatatg gtagaagcgg
     4141 gcgcattact tgcaacatta aactaattta ggaggaagac aatgagctat tttagtgaga
     4201 caatggggaa cctcctgcat cagaccgctt tttttaacct tacctgggga aattttgtga
     4261 tgatcattgt cgcatgcttt ttcctgtatc tggctatcgc gaaggggttt gagccattgc
     4321 ttcttgttcc gatcgcattc ggtatgctgc ttgtaaatat ctatccggat attttcgcag
     4381 acccagagca gatgagcaat ggtgtaggtg gtttattcca ctacttttat gtgttagacg
     4441 agtggtcaat cttaccgtct ctgattttcc ttggagtcgg tgctatgaca gatttcggac
     4501 cgctgatcgc aaacccgatc agtttcctgc ttggagctgc agctcagttc ggtattttcg
     4561 gagcgtactt ccttgcaatc atgatgggct ttaatgataa ggcagcagct gctgtttcca
     4621 ttatcggtgg agccgacgga ccgacctcca ttttccttgc cggaaagtta ggacagtcgg
     4681 gactgatggg accgatcgct gtggcggcat attcctatat ggcgcttgtg ccgatcatcc
     4741 agccgccaat tatgaagctg tttacaacca aaaaagagcg tgccattaag atggagaact
     4801 taagaccggt ttccaagctg gagaagattc tcttcccgat cgtggttacg gtggttgtat
     4861 gtacgattct tccgacgaca gcgccgctgg ttggtatgct gatgctcggt aacctgttcc
     4921 gcgagagcgg tgtggtccgc cagctgaccg ataccgcatc caacgcattg atgtacatcg
     4981 tagttatcct gctcggtact tccgtaggtg catctacgag tgcggaggcg ttcttaaata
     5041 caacgacatt aaagatcgtt gcacttggac tgattgcatt tatgttcggt acagcagccg
     5101 gtgtcctgtt tggtaagctg ttatgcttcc tcacaaaggg caagatcaat cctctgatcg
     5161 gatctgccgg tgtatctgcc gttcctatgg cagcccgtgt atcccagaaa gtcggtgcag
     5221 aggaagaccc gacgaacttc ctgctgatgc atgcgatggg accgaacgtt gctggtgtta
     5281 tcggtactgc agtagcagcc ggtgtattca tggcaatttt cggaatttag tgaaagagca
     5341 aatgccgtca tagacggata gcggtatcaa agtatccgct gataaggagg aaaaaatgtc
     5401 agaagttgtt aaaaaacctt taaaaataac agagacggtg ctgcgtgatg cgcaccagtc
     5461 cctgattgcg acaagaatga caaccgagca gatgcttccg atcgtagaca agatggataa
     5521 ggtcggatac aatgcggttg agtgctgggg cggtgctacc ttcgatgcat gccttcgttt
     5581 cctgaaagaa gatccgtggg atcgtctccg caagttaaga gacggattta agaacaccaa
     5641 gcttcagatg ctgtttcgtg gacagaacat cttaggatat cgtccgtatg cggatgatgt
     5701 ggtagagtat ttcgtacaga aatcgatcgc aaacggtatt gatatcattc gtattttcga
     5761 ctgcttaaac gatgtccgca acctgcagac agccgttacc gcatgtaaca aagagaaagg
     5821 acatgcacag gtcgcattat cctatacact tggcgatgcc tacactctgg attactggat
     5881 ggagatggcg aagaaggtag aggatatggg tgctgattcc ttatgtatca aggatatggc
     5941 aggtcttttg gttccgacga aggcaaccga gctgattcag gcattaaagt ctgcaaccaa
     6001 ccttccgatc gagctccata cacactatac ttccggtgtc gcttccatga catacatgaa
     6061 ggcggttgag gcaggttgtg acattatcga tacagcaatg tctccgttct ccatgggaac
     6121 cagccagccg gcaaccgagg ttatggtaga ggcattcaag ggcacagagt tcgataccgg
     6181 tctggatcag aacctgttag ctgagatcgc tgactacttc cgtccgatgc gtgaggaagc
     6241 gttagagagc ggtctgatga acccgaaggt tctcggcgtt aacatcaaga ctctgttata
     6301 tcaggtaccg ggtggtatgt tatccaacct tctgtcccag ttaaaagagc agggcaagga
     6361 agacaagttc gaggaggttc ttgcagaggt tccgcgtgtg cgtaaagacc tcggtgagcc
     6421 gccacttgtt acaccgtcct cacagatcgt tggtacacag gctgtgttca acgtactgat
     6481 gggagagcgc tacaaagtgg caaccaagga gaccaaagac gtactgcttg gaaagtacgg
     6541 tcagactgta aaaccgttca acccggagat cgtagacaag gtacttggcg aggagaagaa
     6601 gaacgccatt acctgccgtc cggcagatct gcttgagccg gagctggata agatcgaggc
     6661 tgagatgaag cagtggaagc agcaggatga ggatgtactg tcctacgcac tgttcccgca
     6721 ggttgcaacc gaattcttca agtaccgtga ggcacagcag aagaaggtcg atgcaagcgt
     6781 cgcagatact aagaacggag catatccggt ataatcaaaa aacagttata acaaaaagcg
     6841 ggtgagcagt cacctgcttt ttttgctgcc ctttttgcta ttttatcaca ccgcaggcaa
     6901 tccgttcgcc ggagtcgccc gcgggctgcg ttgtaaagtt atccggcatc cggtgaatga
     6961 tgagggattt tccgataatt tccggaatcg taaaacgctt gtcataaaat gccatccagg
     7021 cataaccctg gttgcccaga agcggaggca tgtcgccgct gtgattcggg tgttcggccg
     7081 gcgtacggct gtaatgggca ccggcactgg taaacgggga gacgcacacg ccgttttcgt
     7141 ggatgtgcat gccgtaaaaa ttactggagc cgggagccgc gacgttcgga agaccgaaga
     7201 cttcaacctc cacgagagtt ccttcgtatt ctgtggcata gaaccgggca agcccggaga
     7261 tggaagggaa attgttgccg ccggcaatcc aggcggatgc atccggcgga gactgcatca
     7321 gtgtatgaat aaaattggtt gctggtgtga tatcgcgcat agctgcctca atggaagagt
     7381 gtcgttggtt tattatatgc agcggcagaa aaatgcgctg catgtaagga aagttccatg
     7441 cataatttct tgcaaaacac catgtatttg atataataaa aacattgagc ggatcacaat
     7501 tccgcagaag tgaggagaag catgagcaat acaaatgacc tgagtaaccg catcaatgat
     7561 gcttacagta agctgagcaa gggacagaaa cggctggcaa cctacattac ggacaattat
     7621 gacaaggcgg tatttctgac cgctgcaaag ctgggcgagg ttgtaggtgt gagcgagtcc
     7681 acggtggtgc gctttgcaac gcatctggga tataaggggt atccggaatt ccagagtgcg
     7741 ctggaggaac tggtgcgcaa taagctgaac tccattcagc gcatggaggt tacttacggc
     7801 aggatcagcc agtcgaagat tctggagacg gtgctgaaat ccgatgcgga caagattcat
     7861 tccacactgg aaaagattga tcagaacgca tttgaactcg cggttgacac gatcctgcac
     7921 gccaaacata tctatatcat cggaatccgg agctgtgcgc cgcttgccag cttcatggct
     7981 ttttatttta ccctgatgtt tccgaacgtt catctgattc agacaagcag ttcgagcgag
     8041 atttttgaac agatggtgcg catcggcaag gaggatgtga tcatcggaat cagttttccg
     8101 cgttattcca tgcgtacttt aaaggcgatg gaatttgcga ataaccggag cgcaaaggta
     8161 atcacactca ccgacagcgt acattccccg atgaacctct attcttcctg caatctgatt
     8221 gcggacagcg atatggcttc cattgtggat tccctggttg ccccgctgtc ggtgatcaat
     8281 gcgctgattg tggcgctctg catgaaaaag cagaacgagg tggcgaaaac gcttgagatg
     8341 ttagaggata tctgggacga ataccaggtt tacgagaacg atgagatcaa ttatatcgat
     8401 gattccatca agatgcggta tggaaaagta ggagatgcgg aactgtatga gtaaggtgat
     8461 cgtagtcggc ggcgggccgg cgggaatgtt tgctgccatt gcggcggcgg agcggggaca
     8521 tgaggtcgtt ttgctcgaga aaaatgaaaa gcttgggaaa aagctctaca tcaccggcaa
     8581 agggcggtgc aacatcacga atgcagggga tatggacacc ctgtttgcca atgtgatgac
     8641 gaacccaaag tttttgtaca gcgcttttta cgattatgac aatcagagag tgattgattt
     8701 ttttgaggag aatggtctgg cgacgaaggt agagcgcggc aaccgtgtat tcccggtatc
     8761 ggatcattct tcggatgtga tcgccacgct acagcgggta ctaaagcgca cgggtgttat
     8821 ggtgcagctt catgcggaag tgcggcagat cctcaccggg gaaggcgcgg tgcgcggcgt
     8881 gaagcttgcc gacggaagcg ttcttgaagc agagcgcgtg attcttgcaa ccggaggatt
     8941 ttcttatcag acgaccggtt cgaccggaga cggctaccgt tttgcgaggg aactcggaca
     9001 tacggtgaca cagattacgc cgtcactggt tccgttctac gtgaaggaga cctgcgcggc
     9061 gaggatgcag gggctggcgc tgaaaaatgt gcaggtgcgc atccgggacg gaaaaaagct
     9121 gttgtatgac gaattcggcg agatgctctt tacccatttc ggggtaagcg gaccgctgat
     9181 tttaagcgcc agtgcggcaa tcaagccggg ccgcgtggag aaggaactgg cgatggagat
     9241 cgacttaaag ccggcactca cggaggaaca gctggatgcg agacttctgc gtgaattcga
     9301 ggaggcaaag aataagcagt ttaaaaacgc cgtcgtgcat ctgttcccgg cgaagatgat
     9361 tccggtgatg ttagaagccg gagcgattga tccggagaag aaggtcaacg agatcacgag
     9421 agaggagcgg atgggatttg tgcatctgat caaggcgttt ccgctgacgc tctgcggtgt
     9481 cagagatttc aatgaagcga tcatcacacg cgggggtgtc agcgtaaagg aagtgaaccc
     9541 ttccacgatg gaatcaaagc ttgtgccggg attgtatttc tgcggggaac tattggatct
     9601 ggatgcgatg accggcggat ttaatctgca gattgcctgg tcgaccgggc atctggcggg
     9661 tgagagtatc gaatagaaga ggagagaaga agagatgagt atgaatattg cgattgacgg
     9721 accggcaggc gccgggaaga gcacaattgc gaaaaaactg gcgaaaaagc tggcgtttgt
     9781 ctatgtggat acgggagcaa tgtaccgtgc gatggcatac tattttttac agaacggcat
     9841 tgcaccagat gatgagcagg cgattgcggc agcctgcccg aaggttgacg tgacgattgt
     9901 gtatgagaac ggcgaacagc aggtgctctt aaacggagag aatgtaaacg gcgtcattcg
     9961 gacggaggaa gtcggcaata tggcatcagc gaccagtgtc tatccggttg tgcgcacaaa
    10021 gcttgtggaa ctgcagcggc agcttgcgac aaagacggac gtcatcatgg acggaaggga
    10081 tatcggcacc tgtgtgcttc cggatgcgca ggtaaaaata tatctcacgg caagcgttgc
    10141 aacgcgcgca aagcgcagat atgatgaact gaccgccaag ggaacccagt gcaatctgga
    10201 agagatcgag aaagatattg aagaccgcga ttaccgcgat atgcaccggg agacgtcgcc
    10261 gttaaagcag gccaaggatg cggtgttagt ggacagctcc gagatgaaca tcgacgaagt
    10321 ggtggacgca atctatcaga tttatgcgag ggtatagaga atatgaatgt aatcttggca
    10381 aagagcgcgg gcttctgctt cggggtaaaa cgtgccgtgg atacggtata tgaacggatt
    10441 ttggaaaaag aaccgctcta cacgttcgga ccgatcatcc acaatgaaga agtggtgcgt
    10501 gatctggagg aaaagggcgt cgtcgtggta aacgatgtgg acgaacttgc ggggaagccg
    10561 caggggacgg taatcatccg ggcacacggc gtggagagag gtgtctgcga gaaaatacag
    10621 gcgctcggct tttccatcgt ggacgcgacc tgcccgtttg tgttaaagat tcaccggctg
    10681 gtggagcgct acagtgggga ggactgtcac attgtgatcg tcgggaatgc cagccacccg
    10741 gaggtgaaag gcatcaaaag ctggtcgaat gcagaggata cgcgcgtgat cggaacccgc
    10801 gaagaggccg aaaaatacga tgcttcccat gggaaaaagg tatgtattgt atcacaaacg
    10861 acatttaatt acaataaatt tcaagaatta gttgaaatta taaaagaaaa aggttatgat
    10921 ataattgttt taaatacaat ctgcaatgct acggaggaac gtcagacgga agcccgggca
    10981 atcgcggagc aggtggatgc catgattgtg atcggtggca ggaacagttc caacacgcag
    11041 aagctatttg aaatatgtaa aaacgaatgc aaaaatactt actatataca aactgtaaag
    11101 gatcttgacc ttgccgaagt caggtctgtc gataacgtag gtattaccgc aggggcttct
    11161 accccaaaca atattattga ggaggttcaa aagaatgtca gaaatgagct ttgaacaaat
    11221 gctggaagaa tcatttaaaa caataagaaa tggagaggta gttgagggta ccgttatcga
    11281 tgtgaaacct gatgagatcg ttctgaatat cggctacaag gcagacggaa tcattactcg
    11341 taatgaatac acaaacgaag caaacgtaga ccttaccaca ttggtatccg tcggcgacac
    11401 catggaagca aaggttttaa aggtaaatga cggtgagggt caggtattac tgacatacaa
    11461 gcgtctggct gccgagaagg gaagcaagag attagaggaa gcatttgaga acaaggaagt
    11521 gctgaccgct aaggttgcac aggtactgga tggaggatta tgcgtaaacg tagatgagac
    11581 aagagtattt attccggcaa gtcttgtatc agatacctac gagaaggatc tttccaaata
    11641 caaggatcag gagatcgagt tcgttatcag cgagttcaat ccgaagagaa gaagaatcat
    11701 cggcgacaga aagcagcttc tggttgctaa gaagttagag cagcagaaag aactgttcgc
    11761 aagaatcaag attggtgatg tattagaggg aacagttaag aatgtaacag atttcggtgc
    11821 gtttattgat cttggcggag cagacggtct gcttcatatt tccgagatgt cctggggcag
    11881 agtagagagc ccaaagaagg tattcaaggt aggcgatcag gttcgcgtat tcatcaaaga
    11941 tatcaatgag aataagattg cactcagcat gaagttcccg gcagagaatc cgtggaacgg
    12001 cgcagcagag aagttcgcaa tcggcaacgt tgtaaagggc aaagttgcaa gaatgacaga
    12061 cttcggcgca tttgttgagc ttgcaccggg tgtggatgca ctccttcatg tatcccagat
    12121 ttccaaggag catgtagaga agccgtccga cgtattaaaa gttggacagg agatcgaggc
    12181 aaagatcgtt gatttcaacg aggaagagaa gaagatcagt ttatctatga aggcactgct
    12241 cgcaccggaa gaagatgcgg atgcagatgt tgcagatgta gatattgatg cggttgcaaa
    12301 ggaagaggag taatctctga tttcgatgat tgcagagtta cagataggct tgcacgttgg
    12361 tggaagccta tttctgtatt tgcatcctgt agataacaaa gagagtcgag ggataaaata
    12421 tgctggaaac ggacaattat gaaaagttta aaaaggatat tttagcgctt gcaaagattg
    12481 atctgaattc ttataaggaa aagcagatgc ggcgcagaat caacacgctg attacgaaga
    12541 atcatattgc gacatatgat gagtatgtgg cgctgatcaa gaaggacaaa gagaagtttg
    12601 aacagtttat caatttcctg accatcaatg tgtcggagtt ttaccgcaat ccggatcagt
    12661 ggaagattct ggagaatgag gtgttcccga agctgattca gaagtttggc aagaatctga
    12721 aaatctggag tgctgcctgc tcgaccggag atgagccgta ttcgctggta atggcattgt
    12781 ccagacacct gccgcttgca aacatcaagg tgattgcgac cgacattgac aagcaggtga
    12841 tcgatacggc gcggatggga ctctacaatg agaagagtat cgcaagtgtg ccggatgatt
    12901 tgaagaagaa gtattttacc aaggtcggca attcgtatca gatctcggat gagatcaaga
    12961 aacgtgtgga attcaaggag catgatcttt taaaagatcc gtatccaggc ggatgcaatc
    13021 tgattgtgtg ccggaacgtt gtgatctatt ttaccgagga ggcaaaggac gagatttatg
    13081 cgaagttcta taaggcgctt gcaacaggcg gcgtgctttt catcggaagc acggagcaga
    13141 tcatgaatta ccgggagatc ggatttgaga gagacaagtc ctttttcttt gagaaggcgt
    13201 aaggttatat cagaggacgc atttttctat aaagcaaaaa agcggcagga aagaagctgt
    13261 gcagtatatg ccagattctt tcctgccgtt tttggtggta attatatcag ggctttctgc
    13321 catgtgttta tttgcggtgg gaacgcatgg tttctaacag atgcagaaca tagtccgtct
    13381 gcatagcggg atcggcggca aagtccgcgg ataattcaaa atagcatttc ctgccgcgcg
    13441 gctgttcacg gaacaccggg gaaaacatgg cgtcatactg cggaagaaag atggcatatt
    13501 ttttgccgta gcagttggaa gcgttcgcct gcacgcggtg ttctttgtcg acggcggatg
    13561 caatactctt gtgaactgcg atatcctccg cagggagata gtagtaatct ttgggactgc
    13621 cgtcataaaa gaagcgcagt tctccctcga agagacgtac acgcagccgg gcggtacttc
    13681 cgctcatgga gagataacag tcatcgtagg agaaggagac cggtttggga acggggtact
    13741 gcagcgccag tgtaaaaaac agctccttgt tgccggaggc accgtccatc gaccggtact
    13801 cggacgcctg gagtgactgc agagaaaatg cctgttccca gagttttggg taggagagga
    13861 cgggcagaag cttcggcata tagagaacgt cctcatagtt gtgctgtttc agcagtgcaa
    13921 gggaatcctt tgcgggatgc cgcacgtact ctttgtagac ttcgatcagc tcgccgccgg
    13981 agtaggcgtc gatgcggtca atcccgagaa acagttcgat ggatttctgc ttgtagctgg
    14041 tcagggcaaa cagaaatttg aaacgtgaga cttccttata aagatcgata taactgtgcg
    14101 catcaaacgg atcggaaagg tgcagcgcct tgcatttcgc cttcaggtat ggaatgtcga
    14161 agccgatacc gttgaacgtc agaatggtat catagccgga caagagctcc agaaaggcgg
    14221 aaaggacatt tttctgatcg gcggcgttct cggaaaagaa ctggtcgatg cacaaaagac
    14281 tgtcgcgcct tgtggcgcag ccgatcaggt agagatccgt gcgcgccggc gagaagccgg
    14341 ttgtctcaat atcaaaaaaa atgcagtttt ctgtaaatac ctcgttggaa acggggtctg
    14401 aaaaatcaaa agtcagttct tcatgccagg ttatcatctg aaaatcctct gtatgtaata
    14461 ttagggtaag agttccaatt ttgccgcagt gcaggtctgg aaaggcatag atttcccgg
//
