LOCUS       gnlProkkaPMNOMMPP_145  12783 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PMNOMMPP_145.
ACCESSION   gnlProkkaPMNOMMPP_145
VERSION     gnlProkkaPMNOMMPP_145
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-02 04:19:27
            Original ID  :: gnl|Prokka|PMNOMMPP_145
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12783
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12783
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[2112:9877]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2113..9877
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..12783
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12783
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             complement(3..386)
                     /locus_tag="ctg145_1"
                     /transl_table=11
                     /translation="MRTLLLYLSLFFLSIATVHAQSMKKMVQKTEFENRLAKEAQTVES
                     IESDFTQVKYLDVFDEKVTSKGKFYYQKSNKICMEYFRPMDYLIVINGSKLKIVSDGKK
                     SIMNLSSNKMMAQMQDMLTACMIG"
     CDS             complement(398..1078)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235:polysaccharide deacetylase (Score: 124.2;
                     E-value: 1.1e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg145_2"
                     /transl_table=11
                     /translation="MMIVCLLLCLFLILSFLVYASYSIQSGIYLRSFCKKRTTEKVVAL
                     TFDDGPDPIQTPKVLEVLKEYQATACFFCIGHKVKGNETLLKSMVTEGHLIGNHSYSHS
                     GLFPLYGLSKMKKDLQTCQCELERVTSQPVTLFRPPFGVTNPTIAKAVRQLGYTSIGWS
                     IRTLDTQQSAPDKILARIRKRLEPGAIILLHDRMPGSDQLVKQILDLLKEQGYTVVRPD
                     KLLA"
     CDS             complement(1075..2100)
                     /locus_tag="ctg145_3"
                     /transl_table=11
                     /translation="MQPVYIQRIASIHPQGNHSQGNNPKVNDSPDVAANRPFLQACEPD
                     YKDIIANATLRRRMSRIVKMGVACGLECMGELSPEKIGGIITATGLGCLVDTEKFLNNL
                     LDNEERMLNPTPFIQSTFNTIGAQIALIHQIHTYNMTYVHRGLSFESALLDAMMKIEEG
                     SENILVGAMDEMTETSYIIQQRLGLLKGIEAGEGAQFFLLSREAGEHPLAEIRGLETFT
                     GQHTTEEISSRIIRFLQRNGLECQDIQWLVTGKNKKQSLQGDYHEQITNSIYEELETNL
                     FPESIHLSFKDECGEYPTASSYAVWKAVKTSINCTTPTNILIYNHHHSINHSLILIRKS
                     V"
     CDS             complement(2113..3402)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (159-417). E-value:
                     4.2e-39. Score: 126.4. Matches aSDomain:
                     nrpspksdomains_ctg145_4_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 258.2; E-value:
                     2.4e-78)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg145_4"
                     /sec_met_domain="APE_KS2 (E-value: 5.8e-115, bitscore:
                     374.3, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIYVTGLGVVSGIGIGVSENIEALQQGKHGIGKVTLFPTALDVP
                     VSEVKRSNEELKQLLSLPPQRTVSRTALLGMIAAKEAMEDAGLNLRISSNQPKNQLPNQ
                     SVTSQKDQQPLRIGFISATSVGGMDLSERFYESFKRNPKQGRLREVISHDCGANTELIA
                     SYLGINDFITTISTACSSAANAIMLGARLIKHGQLDAAIVGGTDALCRFTLNGFNSLMI
                     LDKIHCRPFDRSRTGLNLGEGAGYLVLQSESSLQRVPYCELSGYANTNEAYHQTGSSPE
                     GDGAFLSMSEAIASSGISPEDIDYINVHGTGTPGNDASEGIALRRIFGEHVPPFSSVKA
                     FIGHTLGASEGIEAVYSVLSIDKGMIYPNLNFTEPMPETELLSETGLIPETSFQKGLPI
                     RHVLSNSFGFGGNDSSLLFSATNLPKRTNL"
     aSDomain        complement(2152..2925)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg145_4_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="4.20E-39"
                     /label="ctg145_4_PKS_KS.1"
                     /locus_tag="ctg145_4"
                     /protein_end="417"
                     /protein_start="159"
                     /score="126.4"
                     /tool="antismash"
                     /translation="ELIASYLGINDFITTISTACSSAANAIMLGARLIKHGQLDAAIVG
                     GTDALCRFTLNGFNSLMILDKIHCRPFDRSRTGLNLGEGAGYLVLQSESSLQRVPYCEL
                     SGYANTNEAYHQTGSSPEGDGAFLSMSEAIASSGISPEDIDYINVHGTGTPGNDASEGI
                     ALRRIFGEHVPPFSSVKAFIGHTLGASEGIEAVYSVLSIDKGMIYPNLNFTEPMPETEL
                     LSETGLIPETSFQKGLPIRHVLSNSFGFGGNDSSLL"
     CDS             complement(3406..3687)
                     /NRPS_PKS="Domain: PP-binding (22-68). E-value: 5.7e-11.
                     Score: 34.7. Matches aSDomain:
                     nrpspksdomains_ctg145_5_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg145_5"
                     /sec_met_domain="PP-binding (E-value: 1.5e-11, bitscore:
                     34.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLDQTKRELMDEVKGKLIEELNLEEITPEDIDDEAPLFGDEGL
                     GLDSIDALEIILILEREYGIKIENPSEGKQIFYSVCTLTDYIIANRKA"
     aSDomain        complement(3484..3621)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg145_5_PP-binding.1"
                     /evalue="5.70E-11"
                     /label="ctg145_5_PP-binding.1"
                     /locus_tag="ctg145_5"
                     /protein_end="68"
                     /protein_start="22"
                     /score="34.7"
                     /tool="antismash"
                     /translation="LNLEEITPEDIDDEAPLFGDEGLGLDSIDALEIILILEREYGIKI
                     E"
     CDS             complement(3680..5530)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (159-410). E-value:
                     7.2e-29. Score: 92.7. Matches aSDomain:
                     nrpspksdomains_ctg145_6_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 177.7; E-value:
                     6.3e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg145_6"
                     /sec_met_domain="APE_KS2 (E-value: 2.9e-109, bitscore:
                     355.6, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHPLNIYITAHTLISSLGFGISENRKAIHDYRSGIRMQEAGRIS
                     DSPILAGMIDSVELENRAKEQLEKRAKELDISSYTRLEQLFILTIQEVISQSGVNLQEP
                     DCALLLSTTKGNIDLLRDQEKRTNSDKPSGSVQSTIDNPSFLQELSADSPTFLWKMAER
                     IGHFFEAANQVEVISNACISGVSSLVVAKRWIESGRYKRVIVAGGDILSHFITSGFLSF
                     RSVSAHRCRPYDIQRDGLSLGEACGAVLLETQGNANHIILSGGAISNDANHISGPSRTG
                     DGLALAINQAMEEAGALPEDISFINAHGTATVYNDEMESKAIHLAGLSAVPVNSLKPYF
                     GHTLGASGIIETILCIEQLKEGIYYGTLGYETQGVPMPITVYNTHQPMPMKCCIKTASG
                     FGGCNAALVLSLPDAHLKQKTDSLASCKAAVESANTVTIKPGVVENQGTAIFNSSETDF
                     APFIREAYKHLGENNMKFYKMDNLCKLGYVAAGYLLKDTNYQPKEIGIILANASSSLDT
                     DCKHQAIINKEGDKAASPAVFVYTLPNVVLGEICIRHKIQGENTFFVCQQSDVASLEDY
                     ARIVMAKGKLRTCIIGWCELLDGHYQAEFKQLNNISTIYE"
     aSDomain        complement(4301..5053)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg145_6_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="7.20E-29"
                     /label="ctg145_6_PKS_KS.1"
                     /locus_tag="ctg145_6"
                     /protein_end="410"
                     /protein_start="159"
                     /score="92.7"
                     /tool="antismash"
                     /translation="MAERIGHFFEAANQVEVISNACISGVSSLVVAKRWIESGRYKRVI
                     VAGGDILSHFITSGFLSFRSVSAHRCRPYDIQRDGLSLGEACGAVLLETQGNANHIILS
                     GGAISNDANHISGPSRTGDGLALAINQAMEEAGALPEDISFINAHGTATVYNDEMESKA
                     IHLAGLSAVPVNSLKPYFGHTLGASGIIETILCIEQLKEGIYYGTLGYETQGVPMPITV
                     YNTHQPMPMKCCIKTASGFGGCNAALVLS"
     CDS             complement(5515..5958)
                     /locus_tag="ctg145_7"
                     /transl_table=11
                     /translation="MKRKTNQQIAALTNRTTFKVRFSEIDSMQIVWHGEYVRYFEDGRE
                     AFGKQYGLDYMSIYREGYMVPIVDLTCQFKQSLSFGEEAIIETRYLACEAAKIKFEYVI
                     YRATDQSVVATGSTIQVFLNLNKELELINPPFYLEWKKKWNIL"
     CDS             complement(5955..6389)
                     /locus_tag="ctg145_8"
                     /transl_table=11
                     /translation="MNREAVIQGEGILNLIPQRPPIVMVDSFFGFEENRSYSGLTVTTD
                     NLFCEAGRLQEPGIIEHIAQSAAARIGFIYTRQGEKVPLGFIGSVDKLKIYNLPEAGMK
                     LFTEITVVQEVFDITLISAQVKTEEELIAECKMKIFIKKE"
     CDS             complement(6386..7456)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 126.3; E-value:
                     2.5e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg145_9"
                     /transl_table=11
                     /translation="MQQNKYDKEPLTAVEAQRLAQEIAFGPIVFQVSRLMLKFGIFQLL
                     ADERKGMTQEEISKACGLSSYGAQVLLEASLTIGTVLLREGRYFLAKAGWFLLNDKMVR
                     VNMDFNHDVNYQGMFHLEEAITNGRPEGLKVFGEWSTIYEGLSSLPSQVQKSWFGFDHY
                     YSDCSFDEALAIVFARHPKTLLDVGGNTGRWATKCVSYDDTVEVTIMDLPQQLEMMRQQ
                     TKELPGATRIHGHGANLLDPEVPFPTGFDAIWMSQFLDCFSEEEVTSILTRAARSMSRE
                     SRLYIMETFWNRQKFDTAAYCLTQISLYFTAMANGNSKMYHSDDMQRCIEAAGLEIEEI
                     HDHLGMGHSIVQCRLK"
     CDS             complement(7443..8378)
                     /locus_tag="ctg145_10"
                     /transl_table=11
                     /translation="MSTWKGKTRGGTFGYLFFIYLIKYLGITAAYLFLSLVVLYFIPFA
                     PKATKSTWFYARHILKYNRIRSLKMLLLNYYRLGQILIDKVAIGNGKVNQYQFKFERYP
                     EFLQLLNSEQGVIMIGAHVGNWEIGVPFFDDYGKKINIVMYDAEHRRIKEILEKNGQDK
                     EFKIIPVNEDNLTHVFRITEAINQKEYVCFQGDRYLNKEKLLPGILLGQKAPFPAGPFL
                     LASRMKVPVVFYFAMRESGRTYRFHFIIAEPVVRTKEKKAEMALLEQYTVALEQILKRY
                     PEQWFNYYPFWEPAGKQSPDLKEKQKDATE"
     CDS             complement(8381..8632)
                     /NRPS_PKS="Domain: PP-binding (7-75). E-value: 3.8e-14.
                     Score: 44.9. Matches aSDomain:
                     nrpspksdomains_ctg145_11_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg145_11"
                     /sec_met_domain="PP-binding (E-value: 1e-14, bitscore:
                     44.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEEIIEKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDM
                     VVLVEKNFGFNVTGQDFAGIKTFQDFYDLVITRMQEAK"
     aSDomain        complement(8408..8611)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg145_11_PP-binding.1"
                     /evalue="3.80E-14"
                     /label="ctg145_11_PP-binding.1"
                     /locus_tag="ctg145_11"
                     /protein_end="75"
                     /protein_start="7"
                     /score="44.9"
                     /tool="antismash"
                     /translation="EKIRTTLAEEFEVDIDVIQPDAPLMETLELDSLDLVDMVVLVEKN
                     FGFNVTGQDFAGIKTFQDFYDLV"
     CDS             complement(8654..9877)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (65-405). E-value:
                     6.3e-53. Score: 172.0. Matches aSDomain:
                     nrpspksdomains_ctg145_12_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 293.9; E-value:
                     3.4e-89)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg145_12"
                     /sec_met_domain="APE_KS1 (E-value: 2.2e-159, bitscore:
                     520.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVVITGMGIYSCIGKNLDEVKDSLYNGKSGIGIDPVRKELGYF
                     SALTGILERPDLKKLLDRRKRLCLPEQGEYAYLATLEAFRNAGIDDAFLEANEVGILYG
                     NDSSAAPVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACA
                     SGSHAIGMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAEPEKASKPFDK
                     RRDGLIPSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQM
                     AIKDAGIALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAG
                     ASEVIYSTLMMNNGFIAPNLNFEEADEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNST
                     LIIRQIKE"
     aSDomain        complement(8663..9682)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg145_12_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="6.30E-53"
                     /label="ctg145_12_PKS_KS.1"
                     /locus_tag="ctg145_12"
                     /protein_end="405"
                     /protein_start="65"
                     /score="172.0"
                     /tool="antismash"
                     /translation="RLCLPEQGEYAYLATLEAFRNAGIDDAFLEANEVGILYGNDSSAA
                     PVINAVDIIREKKNTALVGSGSIFQSMNSTVTMNLSVIFKLRGVNFTIAGACASGSHAI
                     GMGYLLIKSGLQDCILCGGAQEVNPYAVGSFDGLSAFSTQEAEPEKASKPFDKRRDGLI
                     PSGGAASLVLESYESAVKRGAPILAEVIGYGFSSNGDHISVPNVDGPKRSLQMAIKDAG
                     IALEQISYINAHATSTPVGDLNEAKAIAEVFEGHHPYVTSTKSMTGHEMWMAGASEVIY
                     STLMMNNGFIAPNLNFEEADEASAQLNIPTQRVNLEFDTFLSNSFGFGGTNSTLIIRQI
                     "
     CDS             complement(9904..10632)
                     /NRPS_PKS="Domain: PKS_KR (3-169). E-value: 1.3e-16. Score:
                     52.9. Matches aSDomain: nrpspksdomains_ctg145_13_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     213.5; E-value: 5.8e-65)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg145_13"
                     /sec_met_domain="adh_short (E-value: 4.1e-36, bitscore:
                     114.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYALVTGGSRGIGRAVSCKLAEMGYFILINYQSNDAEAEKTLQL
                     VQEKGSNGEIMKFDVTDPAAIALALNNWASQHPDEYIEVLINNAGIRKDNLMLWMTGEE
                     WNKVLDISLNGFFYVTQPLLKNMLVKRYGRIVNIVSLSGIQGMPGQANYSAAKGGVIAA
                     TKALAQEVAKKKVTVNAVAPGFIRTDMTEGIDENEWKKHIPAGRFGTAEEVAELVGFLA
                     SPASSYITGEVISINGGLYT"
     aSDomain        complement(10126..10623)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg145_13_PKS_KR.1"
                     /evalue="1.30E-16"
                     /label="ctg145_13_PKS_KR.1"
                     /locus_tag="ctg145_13"
                     /protein_end="169"
                     /protein_start="3"
                     /score="52.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVTGGSRGIGRAVSCKLAEMGYFILINYQSNDAEAEKTLQLVQE
                     KGSNGEIMKFDVTDPAAIALALNNWASQHPDEYIEVLINNAGIRKDNLMLWMTGEEWNK
                     VLDISLNGFFYVTQPLLKNMLVKRYGRIVNIVSLSGIQGMPGQANYSAAKGGVIAATKA
                     LAQ"
     CDS_motif       complement(10558..10620)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg145_13_0001"
                     /evalue="2.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg145_13"
                     /protein_end="25"
                     /protein_start="4"
                     /score="13.5"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRAVSCKLAEMG"
     CDS             complement(10634..12157)
                     /locus_tag="ctg145_14"
                     /transl_table=11
                     /translation="MIADKSINLDTLYKVLFDNEKLELSKECIRKVEESFDFLQSFSSD
                     KIIYGINTGFGPMAQYRIEDQSLIELQYNIIRSHSTGAGKPLPELYVKAAMIARLYTFL
                     QGKSGVHMELVSLLCEFINRGIYPFIPEHGSVGASGDLVQLAHIALTLIGEGEVFYQGK
                     LRDAATVLEENGLQPFSMRIREGLSVTNGTSVMTGIGIVNLIYAKKLLRWSVAASVMMN
                     EIAASYDDFMAQALNEAKHHKGQQEIAAMMREWVAGSKCVLQRENELYNQVHKEKIFEH
                     KVQPYYSLRCVPQILGPIYDELKNAEEVLINEINSACDNPIVDPDTQNIYHGGNFHGDY
                     ISFEMDKLKIAMTKLTMLCERQINYLFHDRINGILPPFVNLGVLGLNYGLQASQFTATS
                     TTAECQTLSNPMYVHSIPNNNDNQDIVSMGTNSALLAKTVIENSYQVMAIQFMGMAQAI
                     DYLKIQDRLSPKSWQVYEEIRSFFPVFTNDTPKYKEIERMMDYLKKENK"
     CDS             complement(12315..12746)
                     /locus_tag="ctg145_15"
                     /transl_table=11
                     /translation="MEEIVFHHTLPIQLRFNDVDKFGHVNNTVYFSFYDLGKTEYFASV
                     CPGVDWEKIGIVVVHIEADFVKQIFASDHIAVQTAVSKIGTKSFHLIQRVIDTETNEVK
                     CICKSVMVTFDLERHESMPLTEEWIEAICKYEERDLQKA"
ORIGIN
        1 tcgcctatca tacacgcagt cagcatatcc tgcatctgtg ccatcatttt gttcgaactt
       61 aggttcataa tacttttctt gccatccgat acgattttga gcttactccc gtttatcacg
      121 atgagataat ccattgggcg gaagtattcc atacagattt tattgctctt ttggtagtag
      181 aacttccctt tggaagtaac cttttcgtca aatacatcaa gatatttcac ttgggtaaaa
      241 tcgctttcga tggactccac ggtttgtgcc tcctttgcca ggcggttttc aaactcggtc
      301 ttttgcacca tctttttcat gctctgtgca tggacggtgg cgatagacaa gaagaaaagc
      361 gataagtata gtaataaagt tctcatacat ttttatttta tgccaatagt ttgtccggac
      421 ggacaacggt atatccttgt tcttttagca aatccagtat ttgtttcact aactggtcgc
      481 tgccgggcat ccggtcgtgc aacagaatga tggctcccgg ttcaagacgt ttccgaatcc
      541 tggcaagtat tttgtccgga gctgactgtt gcgtatctaa tgtacggatg ctccatccga
      601 tcgaggtata tcctaactgt cggacagctt tcgcaatcgt aggattagtg acaccgaatg
      661 gcggacgaaa caaagtaacc ggctgcgaag ttactcgttc tagttcacac tgacaagttt
      721 gcaggtcttt tttcatcttg gagagtccgt atagcggaaa taaaccggaa tgactatatg
      781 aatgatttcc aattagatga ccttctgtta ccatactttt caataaagtt tcatttcctt
      841 ttactttgtg tccgatacag aaaaaacagg cagttgcctg atattctttt agtacctcca
      901 atactttggg cgtttgaatg ggatcgggac cgtcgtcaaa agttagggcg acaacttttt
      961 ctgtagtacg ttttttgcaa aacgaccgta gataaattcc cgactgaatg ctataagaag
     1021 cataaacgag aaaggacagt atcaagaata aacataaaag gaggcaaaca atcatcatac
     1081 gcttttccga attagaatca atgagtgatt gatggagtgg tgatgattat aaatcaatat
     1141 attggtaggg gtagtacagt ttattgatgt ctttactgct ttccatacgg catacgatga
     1201 ggcggtagga tattctccac attcgtcctt aaaactaaga tgaatacttt ccgggaaaag
     1261 gttggtttca agctcttcat agattgagtt agtgatttgc tcgtggtaat caccttgaag
     1321 ggattgtttt ttgttctttc cggtaactaa ccattgaata tcctgacact ctaatccgtt
     1381 tcgttgtaaa aaacgaataa ttcgggaact gatttcttct gtcgtatgtt gtcccgtgaa
     1441 agtttcaagt cctcgtattt ctgctaacgg atgctctccg gcttcccggc ttaataggaa
     1501 gaattgagcg ccttctccgg cttctattcc tttcagcagt cccagtcgtt gctgaatgat
     1561 gtaactggtt tctgtcattt cgtccatggc tcccaccagt atattctcgc ttccttcttc
     1621 tattttcatc atggcatcca gcaaagcgct ttcaaaactt agtccccggt gaacataagt
     1681 catgttatag gtgtgtattt gatgaattaa agctatttgt gcaccaattg tattgaatgt
     1741 cgactgaata aaaggagtag gattcagcat ccgttcttca ttatctaaca ggttgtttag
     1801 gaacttttcc gtatcaacca ggcagcccag ccctgtggct gtgataattc cccctatctt
     1861 ctcgggagat agttcgccca tacattccaa tccgcaagct actcccattt tcacaatacg
     1921 gctcatgcgt ctgcgcaaag ttgcattggc aataatatcc ttataatcgg gttcacaagc
     1981 ctgaagaaaa ggacggtttg ctgcaacatc gggcgaatca tttactttcg gattatttcc
     2041 ttgtgaatga tttccttgtg gatggataga agcgatgcgt tgaatataaa ctggctgcat
     2101 aggctcaaaa acttaaaggt tcgttcgttt tggtaaattc gttgcggaaa agaggagcga
     2161 cgagtcgttt cctccgaagc cgaaagaatt ggataataca tggcggatcg gcaatccttt
     2221 ctggaaagat gtttccggta tcaatcctgt ttctgacaac agttctgttt ccggcatagg
     2281 ctccgtgaaa ttcagattcg gataaatcat gcctttatct atggaaagaa cggaataaac
     2341 agcttcaatt ccttcggaag ctcctaaagt gtgtccgata aaagctttta ccgaactaaa
     2401 cggtggaaca tgttctccga agattcttcg tagtgctatt ccttccgatg cgtcattacc
     2461 gggagtacct gtcccatgta cgttgatata atcaatatct tcaggagaaa tgccactgga
     2521 agcgatggct tcactcattg atagaaaggc gccatctcct tcgggagaac ttcctgtttg
     2581 atgataagct tcatttgtat tagcataacc gcttagttca cagtaaggaa ctctttggag
     2641 tgaactttct gattgaagca ctaaatatcc cgcgccttct cccaaattta atccggtacg
     2701 cgaacggtca aaaggacgac aatgtatttt gtccaagatc atgagagagt tgaacccatt
     2761 aagcgtaaat cggcaaagtg catccgtacc tccgacgata gcagcatcca gttgtccgtg
     2821 ttttatcagt ctcgctccca acataatagc attggctgcc gatgaacagg ctgtactgat
     2881 ggtggttata aaatcattga tacctaaata cgaagctatt aattcagtgt tggctccaca
     2941 gtcgtgtgaa atcacttccc gcaatcgtcc ctgtttcggg tttctcttga aagattcata
     3001 gaaacgctcg cttaaatcca taccgccgac agaggtggcg gaaataaaac caatacgtaa
     3061 cggttgttgg tctttttgcg aggttactga ctgattcggt aattgatttt ttggctgatt
     3121 ggatgatata cgcaagttta gtcctgcatc ttccatcgct tctttggcgg ctatcatgcc
     3181 tagcaatgct gtgcgtgata ctgtacgctg cggaggtaaa gataatagtt gtttaagttc
     3241 ttcattgcta cgtttcactt cagatacggg tacatcgaga gcagtcggga aaagagtcac
     3301 ttttccgatg ccatgcttcc cttgttgtag tgcctctata ttttcggaaa ctccgatgcc
     3361 gatgcccgaa acaactccca atccggtgac gtaaatcttc ataagttaag ctttccgatt
     3421 agcaatgatg tagtcagtca gtgtacatac cgagtagaag atttgttttc cttcactagg
     3481 attctctatt ttaatgccat attcacgttc caaaatcagg atgatttcga gtgcgtcaat
     3541 ggagtcaagg ccaagacctt cgtcgccaaa cagaggggct tcatcgtcaa tatcttccgg
     3601 agtgatttct tcaaggttca actcttcgat tagtttacct ttcacttcgt ccatcagttc
     3661 tcttttggtt tgatctaaat tattcataaa tcgttgatat attattaagt tgtttaaatt
     3721 ctgcttggta atgtccgtcc agtagttcgc accagcctat gatgcatgtg cgtaacttac
     3781 ctttcgccat cacaatcctt gcgtaatcct ctaaggaagc aacgtcggat tgctggcaga
     3841 caaagaatgt attctctccc tgaattttgt gtcgaataca gatttctccc aatactacat
     3901 tggggagagt gtagacaaac acggcaggac tggcggcttt atctccttct ttattgatga
     3961 tagcttgatg tttgcagtcc gtatctaaag aggaagatgc attggctaaa atgattccga
     4021 tctctttcgg ctggtagttg gtatctttca ataaatatcc ggcagctaca tatcccagct
     4081 tacaaaggtt atccatcttg tagaacttca tattgttttc tcccagatgc ttgtatgctt
     4141 cccggataaa cggcgcaaag tcagtctctg aagaattgaa tatagctgtt ccttggtttt
     4201 ctaccactcc cggtttgatc gtgactgtat tggctgattc tacggcagct ttacaggatg
     4261 ccagagaatc agttttctgt ttcaaatgag catctgggag agataatacc agtgcggcat
     4321 tacagcctcc gaaaccggaa gcagttttga tacagcattt catcggcatc ggctgatgag
     4381 tgttataaac ggtgataggc atgggaacac cctgtgtctc atatcctaaa gttccgtagt
     4441 atattccttc ttttagttgc tctatgcaga gtatggtttc aataatgcct gaagctccta
     4501 atgtatgccc gaaataaggc ttaagactat tcaccggaac tgcagacaat cctgccaaat
     4561 gtatggcttt ggattccatt tcgtcattat aaaccgtagc tgttccgtgt gcattgataa
     4621 agctgatatc ttcaggaagt gctccggctt cttccattgc ctgattgata gccagcgcca
     4681 gtccgtctcc tgttcgggaa ggaccggata tatggttggc atcattgctg atcgctcctc
     4741 cggatagaat aatatgattt gcgtttcctt gcgtttctaa aagcacagct ccacaggctt
     4801 cgcctaggct tagtccgtcc cgctgtatat cgtatggtcg gcatcggtgt gcgctgactg
     4861 accggaaaga caggaaaccg ctggtaataa aatgagaaag aatatccccg ccagcgacaa
     4921 tcactcgttt gtaacgccct gattctatcc atctcttggc aacaaccagt gacgagactc
     4981 cagatataca ggcgttggag ataacttcta cctgattggc tgcctcaaaa aaatgcccga
     5041 ttcgttctgc cattttccaa agaaaagtcg gactatcggc tgataattcc tgtaaaaagg
     5101 aaggattatc aattgttgat tgtacagaac cgcttggctt gtccgaatta gttctttttt
     5161 cttgatctct caataaatca atatttccct tcgtagtaga gagcaacaaa gcacagtccg
     5221 gctcttgcag atttactccc gattgggaaa tcacttcctg aatagttaat ataaacagtt
     5281 gctctaaccg ggtataagag gaaatatcca gctcctttgc ccgcttttct aattgttctt
     5341 tagctctatt ttccaactcg acagaatcaa tcatccctgc cagaatcgga ctgtcagaaa
     5401 tccgtccggc ttcttgcata cgaatcccgc ttcggtagtc atggattgct ttcctattct
     5461 ccgaaatgcc gaaacctaac gaactaatca gcgtatgggc tgtgatgtat atatttaaag
     5521 gatgttccat ttctttttcc attccagata aaacggaggg ttgataagct ccagctcttt
     5581 attcaggttc aggaacactt gtatggtgct tccggtagcc actacactct ggtcggtagc
     5641 ccggtagata acgtattcga atttgatctt ggctgcctca caggcaagat agcgtgtttc
     5701 gataatcgct tcttcaccaa aggacaatga ttgcttgaac tgacaggtta aatctacgat
     5761 gggaaccatg tagccttccc ggtaaatgct catataatcc aaaccatact gtttgccgaa
     5821 agcttcccgc ccatcctcaa agtagcgcac gtactcgcca tgccatacaa tttgcatgga
     5881 gtcaatttcg ctgaaccgta ctttgaaagt agtccggtta gtcaaagctg caatctgttg
     5941 atttgttttc cgtttcattc ttttttgata aatattttca tcttacattc agcaatcagc
     6001 tcttcttccg ttttcacttg tgccgaaatt agcgtaatat cgaatacctc ttgtacgacg
     6061 gtaatctctg taaataattt cattccggct tctggcaagt tgtagatttt aagtttgtct
     6121 accgaaccga taaaacctaa cggaactttt tcaccctgcc gggtataaat aaacccgata
     6181 cgtgcagccg ctgattgtgc gatatgctcg ataattcccg gctcttgcag tctgcctgcc
     6241 tcacaaaata aattgtcggt agtgacagtc agtccggaat atgaacggtt ttcttcaaat
     6301 ccgaagaaac tgtccaccat aacgattggc ggacgctgtg gaatcaggtt gagtattcct
     6361 tctccttgta tgacggcttc tctgttcatt tcaatctgca ttgtacgatg ctgtgtccca
     6421 ttcctaaatg gtcatgtatc tcttcgattt ccaatcctgc tgcttcgatg catcgttgca
     6481 tatcatctga atgatacatc ttgctatttc cgtttgccat cgctgtaaaa tagagactga
     6541 tttgtgtcag gcaataagcg gctgtatcaa acttttgtcg gttccaaaaa gtctccatga
     6601 tataaagacg actttcccgg ctcatggaac gggctgcacg ggtcaatatg ctggtaactt
     6661 cttcttccga gaaacaatcg aggaactggc tcatccaaat agcatcgaac cctgtcggga
     6721 aaggcacctc cggatcaagc agattggcac catgaccgtg gatacgtgta gctccgggca
     6781 gctctttggt ttgttgacgc atcatctcca attgttgcgg aaggtccatg atggttactt
     6841 ccactgtgtc gtcgtagctt acgcatttgg tcgcccagcg gccggtattg cctcccacat
     6901 ccaataaagt cttgggatgg cgggcgaaga caattgccag tgcttcgtcg aacgaacaat
     6961 ccgagtaata atgatcgaaa ccgaaccagc tcttttgtac ttgtgaaggc agacttgaca
     7021 acccttcata gatagtactc cattcaccga atactttcag tccttcagga cgtccgttgg
     7081 taatggcttc ttccagatga aacattccct gatagttgac atcatggttg aagtccatat
     7141 tgacacgtac cattttgtca ttgagcagaa accagccggc tttcgcaagg aagtatcgcc
     7201 cttcacgcaa caatacggtg ccgatagtca atgatgcttc caacaatact tgtgcaccat
     7261 aagaggacag cccacaagct ttgctgattt cttcttgcgt catacctttg cgctcgtcgg
     7321 ccaataactg gaagataccg aatttaagca taaggcgtga tacctgaaaa acaataggcc
     7381 caaaagctat ttcttgtgcc aggcgttgtg cctctaccgc tgtcaacggt tctttgtcat
     7441 atttattctg ttgcatcttt ttgtttctct tttaaatccg gtgactgctt tccggcaggt
     7501 tcccagaatg gataataatt gaaccattgt tccggatagc gttttagtat ctgttccaaa
     7561 gcaacagtgt attgttcgag cagagccatc tccgctttct tttcttttgt tcgtactacc
     7621 ggttccgcta ttataaaatg aaaacggtaa gttcttcccg attctctcat agcaaagtag
     7681 aataccaccg gaactttcat tcgcgaagcc agcaggaaag gaccggcagg gaaaggagct
     7741 ttctgtccca gtaaaattcc tggcagaagt ttctctttgt tcagataacg gtcaccctgg
     7801 aaacatacat attctttttg gttgatcgcc tcggttatgc ggaaaacgtg tgtcaggttg
     7861 tcttcattga cagggataat cttaaattcc ttgtcctgac cgtttttctc caggatctct
     7921 ttgattctac gatgttcggc atcgtacatc acgatattga ttttctttcc gtaatcatcg
     7981 aagaaaggaa cgcctatttc ccagtttccc acatgggcgc caatcataat cactccctgt
     8041 tcactgttca gcagttgcag aaactccgga taccgctcga atttgaactg atattgattt
     8101 acttttccat taccgatggc taccttgtca atcaggattt gtcctaatcg gtaatagttg
     8161 agtagtaaca tcttcaaaga acgtatccta ttgtatttca gaatgtgacg ggcataaaac
     8221 caggtgcttt tggttgcttt cggagcaaac ggtatgaagt agagcactac caggcttaga
     8281 aaaagataag cggcagtgat gcccagatac ttaatcaggt aaataaagaa taagtatccg
     8341 aacgttcctc cccgggtttt gcctttccac gtcgacatat ttacttggct tcctgcatgc
     8401 gggtgataac gagatcgtag aagtcctgga aggttttgat acctgcaaag tcttgtccgg
     8461 ttacgttgaa accgaaattc ttttctacca gtaccaccat gtcgaccaag tccagactgt
     8521 ccagttcaag agtttccatt aacggcgcat ccggctggat gacgtcgatg tctacttcaa
     8581 actcttctgc cagagttgtt cttattttct cgatgatttc ttcgtttgtc atatatctgt
     8641 tttctttagt aatttattct ttgatttggc gtataatcag ggtggaattg gttcctccga
     8701 atccaaacga gttggaaagg aacgtatcaa attccagatt tacccgttgg gtaggtatat
     8761 tcaactgtgc ggaggcctcg tccgcttcct cgaaattgag gttgggagcg atgaaaccgt
     8821 tattcatcat gagggtggag taaatcactt cactggcacc tgccatccac atttcatgtc
     8881 cggtcatgga cttcgtggaa gtgacatacg ggtgatgtcc ttcaaatact tccgcaatgg
     8941 ctttcgcttc gttcaggtcg cctaccggag tggaagtggc gtgtgcgttg atataactga
     9001 tttgttcgag tgcaataccc gcatctttga tggccatctg aagagaacgt ttcggaccgt
     9061 ccacattcgg tacggagata tgatctccat tggaagagaa accgtaaccg ataacttcgg
     9121 ccaaaatggg agctcctctt tttactgccg attcatagct ctctaatacc agactggcgg
     9181 ctcctccact cggaatcagt ccgtcacgtc gtttatcaaa aggtttggag gctttctcgg
     9241 gctctgcttc ctgggtggaa aatgcgctta gcccgtcgaa actgccgacc gcataaggat
     9301 ttacttcttg tgcgccaccg caaagaatac aatcctgcaa tcctgattta atgagcagat
     9361 accccatacc aatagcatga gaaccacttg cgcaggctcc ggcaatggtg aagttaactc
     9421 ctctaagctt gaagataacc gacaggttca ttgtcacggt agaattcatc gactggaaaa
     9481 tagaaccgga acctaccaac gctgtgtttt tcttttcacg aatgatgtcc actgcgttga
     9541 taacaggggc ggcactacta tcattgccat acaagatacc cacttcatta gcttcgagaa
     9601 aagcatcgtc aataccggcg ttgcggaaag cctccaaagt agcgagataa gcatactctc
     9661 cctgttccgg caggcagaga cgtttacgac gatctaatag tttcttcaag tcgggacgtt
     9721 ccaatatgcc cgttaatgca gaaaaatagc ccagttcttt ccgtaccgga tctatgccaa
     9781 tccccgattt cccattgtat agtgagtctt ttacttcatc caggttcttg ccgatgcaag
     9841 agtaaatccc cattcccgtg ataacaactc ttttcattat tttgtctatt ctatgctttt
     9901 gttttaagta tatagtcctc cgttgatgga aatcacctcc cctgtgatat aggatgaggc
     9961 cggagatgcc agaaaaccaa ccagttcggc aacctcttcc gcagtaccga aacgtcctgc
    10021 aggaatgtgt tttttccatt cgttctcatc aatcccttcc gtcatatccg tgcggataaa
    10081 tcccggagct actgcgttga ctgttacctt tttcttggcc acttcttgtg ccagtgcttt
    10141 ggtagcagct attacgccac ctttggctgc ggaatagttg gcttgtccgg gcattccctg
    10201 aatacctgac aaggatacga tattgacaat acgtccataa cgtttgacca gcatattctt
    10261 caataaaggc tgtgtcacat aaaagaatcc gttcagacta atatcgagca ctttgttcca
    10321 ttcttctcct gtcatccaga gcatcaggtt gtctttacgg atgcccgcat tgttaatcag
    10381 tacttcgatg tattcgtcag gatgttgtga cgcccagttg ttcaaggcaa gggcaatagc
    10441 ggcagggtct gtcacatcga acttcatgat ttctccgtta cttccttttt cctgcactaa
    10501 ctgcaacgtt ttttctgctt ctgcgtcgtt actctgataa ttaatcagta taaagtagcc
    10561 catttccgcc agtttgcaac tgacagcacg accgatacct cggcttcctc cggttactaa
    10621 tgcgtatttc attttattta ttttcttttt tgagatagtc catcattctt tctatctctt
    10681 tatatttagg tgtgtcattg gtaaatacag ggaagaagct acgtatctct tcatacacct
    10741 gccagctttt gggacttaga cgatcctgta ttttaaggta gtcgatggct tgtgccattc
    10801 ccataaattg tatagccatc acctgataag aattctcaat gactgttttt gctaatagag
    10861 ccgagttggt tcccatgctg acaatatcct gattatcgtt gttgttagga atactgtgca
    10921 catacatcgg atttgataat gtctgacatt cggctgtagt ggacgttgct gtgaattgcg
    10981 aagcctgcaa accgtagttc aatccaagca ctcccaagtt tacaaaagga ggcaggatgc
    11041 cattgatacg gtcgtggaac agataattga tctgtctttc gcaaagcatg gtcagtttag
    11101 tcatggcgat tttcagttta tccatttcga aagagatgta atctccgtgg aagttaccgc
    11161 catgataaat attttgtgtg tccggatcga caatcggatt gtcgcaggcg gaatttattt
    11221 cgttaatcaa tacttcttcc gcattcttca gttcatcata gatgggaccg aggatttgcg
    11281 gaacacatcg caaggaataa tagggctgta ctttgtgctc gaagattttt tctttgtgca
    11341 cctggttgta tagctcattc tctctttgaa gtacgcattt gctgcccgct acccattctc
    11401 tcatcatagc ggctatctct tgttgccctt tgtgatgctt ggcctcgttt aatgcttgtg
    11461 ccatgaaatc atcataagag gcggcaatct cattcatcat gacagaagcg gctaccgacc
    11521 aacggagcag ctttttggca taaataagat tgacgatacc gattcctgtc atcacagaag
    11581 taccgtttgt gacggataat ccttcgcgga tgcgcattga aaaaggttgc agaccgtttt
    11641 cctcaagcac agtagcggca tcacgcaatt tcccctgata aaagacttcc ccttctccta
    11701 ttaatgtcag ggcaatatgg gccagttgca cgagatcgcc gctggcacct acacttccat
    11761 gttcgggtat gaacggataa attccacggt tgataaattc acagagaaga gataccagct
    11821 ccatgtgtac tcctgatttc ccctgtagaa aagtgtacag gcgggcaatc atagctgctt
    11881 ttacataaag ttcgggaagt ggtttgccgg caccggtgga atggcttcga atgatattgt
    11941 actgaagttc gatcagcgac tgatcttcta tccggtattg tgccattggg ccgaaccccg
    12001 tattgatacc ataaataatc ttatcgctgg aaaaagattg taagaaatcg aagctttcct
    12061 ctacttttcg gatgcattct ttagagagtt ccagcttctc attatcaaac aatactttat
    12121 aaagggtatc taaatttata cttttgtcag ctatcatttt ctgtactaga tattttatgc
    12181 cttattaatt aaggtacaaa aataggcaat ttctgttata tagcggacat gaatcagaat
    12241 aaaacttttt ccggagaatt ggttttgctt gttttgtttc tcattcgtga gggggctttt
    12301 tcaaaaaaaa ctatctatgc tttttgcaag tcccgttctt catatttgca gatcgcttct
    12361 atccattcct ctgtcagtgg catggattca tgtctttcaa ggtcgaaagt aaccataaca
    12421 gacttgcaga tacattttac ttcattcgtt tctgtgtcga taacccgctg gatcaggtga
    12481 aagcttttgg tgcctatctt agaaacagca gtctgtacgg cgatatgatc ggatgcgaat
    12541 atctgtttga cgaaatccgc ttcgatgtgg acaacgacaa tcccgatctt ttcccaatct
    12601 actccgggac atactgaagc gaagtattca gtctttccta agtcgtaaaa ggagaagtaa
    12661 actgtgttgt tgacgtgacc aaatttgtct acatcattga atcgcaattg gataggtaat
    12721 gtgtgatgaa atacgatttc ttccattgtt ttctcttaaa cgttttaaat tcgacacaaa
    12781 aat
//
